3O5NA

Tetrahydroquinoline carboxylates are potent inhibitors of the shank pdz domain, a putative target in autism disorders
Total Genus 16
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
16
sequence length
106
structure length
100
Chain Sequence
SDYVIDDKVAILQKRDHEGFGFVLRGIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVGLIRQGGNRLVMKVVSVTRKP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Discovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the shank3 PDZ domain.
pubmed doi rcsb
molecule tags Protein binding
source organism Mus musculus
molecule keywords SH3 and multiple ankyrin repeat domains protein 3
total genus 16
structure length 100
sequence length 106
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature
pdb deposition date 2010-07-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF17820 PDZ_6 PDZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.42.10 Mainly Beta Roll Pdz3 Domain Pdz3 Domain 3o5nA00
4JOKA 2OMJA 4P2AB 3O46A 1X5QA 1WG6A 2OPGA 3ZRTA 3STJA 2QT5A 2R4HA 1UEQA 3TSVA 3CBZA 1VB7A 4WYUA 2I04A 1B8QA 2YUYA 1N99A 4UU5A 1U38A 1WIFA 3CC0A 1TQ3A 4JOJA 2LC6A 2X7ZA 1N7EA 2KG2A 2K20A 1FC7A 1P1EA 2EDPA 5B6LA 5G1EA 5E21A 2LC7A 1KY9A 2ZPLA 2D8IA 4KFVA 2KBSA 2R3YA 3WKMA 4GVDA 1UEZA 3AXAA 1V1TA 4Z8JA 3HVQC 2FE5A 4K6YA 4MPAA 2IWQA 2L4SA 1IHJA 2EEGA 4HOPA 2MX6A 2H2BA 3GGEA 1UITA 2F0AA 2L97A 2M10A 2D92A 2EGNA 1OBXA 4L8NA 2EJYA 3WKLA 2EEHA 2PKUA 1UJDA 4K72A 1WJLA 1GM1A 2KJDA 2O2TA 1NF3C 4OEPA 2IWOA 2H2CA 2EGOA 4NMSA 2VWRA 4KFWA 3MH7A 3MH4A 4E34A 3SHUA 1D5GA 1NTEA 4N6XA 4R2ZA 4Q6HA 3CS0A 2W7RA 1KWAA 1FC6A 2KJKA 2K1ZA 2KPKA 3O5NA 1VJ6A 3RL8A 3SUZA 1WFGA 1RY4A 4HOPB 1U3BA 2EHRA 5E1YA 1Q7XA 3QDOA 3DORA 4F8KA 1X6DA 1WF8A 2EEJA 2JOAA 3GCNA 3MH6A 2E7KA 2KRGA 2H3LA 2IWPA 3GDSA 4P0CA 4EDJA 4JOHA 2AWXA 2VSPA 5A2PA 2EDZA 2UZCA 1WFVA 1I16A 1MFLA 1FCFA 1WF7A 1WHDA 2CSJA 4K78A 4NNMA 3ID4A 1N6DA 2M0TA 1IU2A 3HPMA 1UJVA 5D13A 1KEFA 2JIKA 4NMOA 2VPHA 3SHWA 1QAVB 2EGKA 5G1DA 3ID1A 3EGGC 1U37A 3QE1A 5HJ1A 2RCZA 5GNDA 1UHPA 1BFEA 2LA8A 1OBZA 3GCOA 4FGMA 4NXPA 2M3MA 4NMPA 1RGRA 1K32A 3HPKA 1X45A 3L4FD 3ID3A 1X8SA 3VQGA 4WYTA 2QKUA 2V1WA 5HFEA 2JILA 5E11A 1GQ5A 1V5QA 1SOTA 2JXOA 1V6BA 1W9QA 5F67A 3SOEA 1VCWA 2Z17A 2M0UA 5JXBA 2CSSA 2CS5A 1FC9A 5HFFA 2EXGA 3OU0A 1X5RA 1VA8A 1N6FA 3GJ9A 1UJUA 1ZOKA 2V90A 2AWWA 5HF1A 1YBOA 2DMZA 2VRFA 4JL7A 5HF4A 1VAEA 1RZXA 1V5LA 3VQFA 1Q3OA 1T2MA 2D90A 3NFLA 2IWNA 1L6OA 2PZDA 4XHVA 1M5ZA 1UEPA 2PDZA 4JOEA 5HFDA 2HGAA 2PA1A 1MFGA 1W9OA 2DC2A 3DJAA 3TMHA 3E17A 2YT7A 4NMRA 4E35A 3PV4A 2KJPA 3ID2A 3DIWA 3I4WA 1UEWA 2DAZA 3KHFA 2M0ZA 5HFCA 4O06A 3I18A 4K75A 2Q3GA 3R0HA 1I92A 5DTHA 5E22A 3NFKA 2QKVA 4E3BA 2JWEA 1QAVA 3QO6A 2I4SA 4JORA 2L4TA 4Q6SA 1Z86A 2LOBA 2KOJA 5GLJA 2OZFA 5E6PB 1WI4A 2OS6A 2DM8A 3QJMA 5HDYA 2P3WA 1WH1A 3PDVA 3RLEA 4NNLA 3DJ1A 2EV8A 1ZUBA 1OBYA 3LNXA 1XZ9A 1WHAA 2H3MA 5HETA 1W9EA 2PKTA 1OZIA 2Q9VA 2REYA 5I7ZA 3K1RA 2VZ5A 3QJNA 3CH8A 1UFXA 4GHNA 3JXTA 3EGHC 1IU0A 1Z87A 4Z33A 1N7TA 3K50A 2LUIA 4NXQA 1G9OA 1WI2A 2OCSA 3SFJA 2G2LA 1Q3PA 2EAQA 1R6JA 2PNTA 4OAJA 3KZEA 2FNEA 4H11A 2KYLA 3PS4A 4K76A 2QKTA 1UF1A 2AWUA 3I1EA 2OGPA 3GSLA 3R69A 4GVCA 2HE4A 1N7FA 4Q3HA 4RI0A 1UM7A 3K82A 2BYGA 1MC7A 1X5NA 3QIKA 3PDZA 5FHTA 1U39A 1RGWA 3R68A 4Q2PA 2ENOA 3NGHA 3CYYA 2YUBA 1Y8TA 3GDUA 3PV2A 4G69A 2QBWA 2KPLA 1BE9A 2OQSA 1LCYA 3DJ3A 5EYZA 3KZDA 4LMMA 3CBXA 4Q2QA 2MHOA 2KOMA 5H3JA 2KV8A 1N6EA 4UU6A 1P1DA 2GZVA 4NMQA 3RL7A 1UM1A 2KAWA 2DB5A 4YYXA 3QGLA 5EZ0A 4PQWA 1V62A 2DKRA 5HEYA 3TSZA 2DLSA 5HEBA 4NMTA 1TP5A 1TE0A 2Z9IA 2W4FA 1QAUA 3B76A 4Q2NA 5FB8C 2WL7A 4NXRA 4YDPA 2FCFA 2JREA 2HE2A 2I1NA 4REYA 2JINA 1QLCA 3LNYA 2EDVA 2RRMA 5HFBA 2DJTA 2QG1A 1GQ4A 3FY5A 2I0LA 3OTPA 3GDVA 4JOPA 2KQFA 5HEDA 1PDRA 3BPUA 1TP3A 2FN5A 1Y7NA 2ZPMA 2KOHA 2I0IA 2EEIA 2DLUA 4OEOA 2VSVA 2YTWA 2M0VA 2KA9A 2F5YA 4Q2OA 4JOFA 2OSGA 2YT8A 4JOGA 2G5MB 3PV5A 1SOZA 2AINA 2I6VA 3CBYA 4NMVA 4AMHA 5F3XA 3TSWA 4IC6A 2KL1A
chains in the Genus database with same CATH superfamily
4JOKA 2OMJA 4P2AB 3O46A 1X5QA 1WG6A 2OPGA 3ZRTA 3STJA 2QT5A 2R4HA 3NCVA 1UEQA 3TSVA 3CBZA 1VB7A 4WYUA 2I04A 1B8QA 2YUYA 1N99A 4UU5A 1U38A 1WIFA 3CC0A 1TQ3A 4JOJA 2LC6A 2X7ZA 1N7EA 2KG2A 2K20A 1FC7A 1P1EA 2EDPA 5B6LA 5G1EA 5E21A 2LC7A 1KY9A 2ZPLA 2D8IA 4KFVA 2KBSA 2R3YA 3WKMA 4GVDA 1UEZA 3AXAA 1V1TA 4Z8JA 3HVQC 2FE5A 4K6YA 4MPAA 2IWQA 2L4SA 1IHJA 2EEGA 4HOPA 2MX6A 2H2BA 3GGEA 1UITA 2F0AA 2L97A 2M10A 2D92A 2EGNA 1OBXA 4L8NA 2EJYA 3WKLA 2EEHA 2PKUA 1UJDA 4K72A 1WJLA 1GM1A 2KJDA 2O2TA 1NF3C 4OEPA 2IWOA 2H2CA 2EGOA 4NMSA 2VWRA 4KFWA 3MH7A 3MH4A 4E34A 3SHUA 1D5GA 1NTEA 4N6XA 4R2ZA 4Q6HA 3CS0A 2W7RA 1KWAA 1FC6A 2KJKA 2K1ZA 2KPKA 3O5NA 1VJ6A 3RL8A 3SUZA 1WFGA 1RY4A 4HOPB 1U3BA 2EHRA 5E1YA 1Q7XA 3QDOA 3DORA 4F8KA 1X6DA 1WF8A 2EEJA 2JOAA 3GCNA 3MH6A 2E7KA 2KRGA 2H3LA 2IWPA 3GDSA 4P0CA 4EDJA 4JOHA 2AWXA 2VSPA 5A2PA 2EDZA 2UZCA 1WFVA 1I16A 1MFLA 1FCFA 1WF7A 1WHDA 2CSJA 2GEFA 4K78A 4NNMA 3ID4A 1N6DA 2M0TA 1IU2A 3HPMA 1UJVA 5D13A 1KEFA 2JIKA 4NMOA 2VPHA 3SHWA 1QAVB 2EGKA 5G1DA 3ID1A 3EGGC 1U37A 3QE1A 5HJ1A 2RCZA 5GNDA 1UHPA 1BFEA 2LA8A 1OBZA 3GCOA 4FGMA 4NXPA 2M3MA 4NMPA 1RGRA 5B42A 1K32A 3HPKA 1X45A 3L4FD 3ID3A 1X8SA 3VQGA 4WYTA 2QKUA 4JJ0A 2V1WA 5HFEA 2JILA 5E11A 1GQ5A 1V5QA 1SOTA 2JXOA 1V6BA 1W9QA 5F67A 3SOEA 1VCWA 2Z17A 2M0UA 5JXBA 2CSSA 2CS5A 1FC9A 5HFFA 2EXGA 3OU0A 1X5RA 1VA8A 1N6FA 3GJ9A 1UJUA 1ZOKA 2V90A 2AWWA 5HF1A 1YBOA 2DMZA 2VRFA 4JL7A 5HF4A 1VAEA 1RZXA 1V5LA 3VQFA 1Q3OA 1T2MA 2D90A 3NFLA 2IWNA 1L6OA 2PZDA 4XHVA 1M5ZA 1UEPA 2PDZA 4JOEA 5HFDA 2HGAA 2PA1A 1MFGA 1W9OA 2DC2A 3DJAA 3TMHA 3E17A 2YT7A 4NMRA 4E35A 3PV4A 2JSNA 2KJPA 3ID2A 3DIWA 3I4WA 1UEWA 2DAZA 3KHFA 2M0ZA 5HFCA 4O06A 4FLNA 3I18A 4K75A 2Q3GA 3R0HA 5ILBA 1I92A 5DTHA 5E22A 3NFKA 2QKVA 4E3BA 2JWEA 1QAVA 3QO6A 2I4SA 4JORA 2L4TA 4Q6SA 1Z86A 2LOBA 2KOJA 5GLJA 2OZFA 5E6PB 1WI4A 2OS6A 2DM8A 3QJMA 5HDYA 2P3WA 1WH1A 3PDVA 3RLEA 4NNLA 3DJ1A 2EV8A 1ZUBA 1OBYA 3LNXA 1XZ9A 1WHAA 2H3MA 5HETA 1W9EA 2PKTA 1OZIA 3KDKA 2Q9VA 2REYA 5I7ZA 2VZ5A 3K1RA 3QJNA 3CH8A 1UFXA 4GHNA 3JXTA 3EGHC 1IU0A 1Z87A 4Z33A 1N7TA 3K50A 2LUIA 4NXQA 1G9OA 1WI2A 2OCSA 3SFJA 2G2LA 1Q3PA 2EAQA 1R6JA 2PNTA 4OAJA 3KZEA 2FNEA 4H11A 2KYLA 3PS4A 4K76A 2QKTA 1UF1A 2AWUA 3I1EA 2OGPA 3GSLA 3R69A 4GVCA 2HE4A 1N7FA 4Q3HA 3KDGA 4RI0A 1UM7A 3K82A 2BYGA 1MC7A 1X5NA 3QIKA 3PDZA 5FHTA 1U39A 1RGWA 3R68A 4Q2PA 2ENOA 3NGHA 3CYYA 2YUBA 1Y8TA 3GDUA 3PV2A 4G69A 2QBWA 2KPLA 1BE9A 2OQSA 1LCYA 3DJ3A 5EYZA 4JJ3A 3KZDA 4LMMA 3CBXA 4Q2QA 3GABA 2MHOA 2KOMA 5H3JA 5IL9A 2KV8A 1N6EA 4UU6A 1P1DA 2GZVA 4NMQA 3RL7A 1UM1A 2KAWA 2DB5A 4YYXA 3QGLA 5EZ0A 4PQWA 1V62A 2DKRA 5HEYA 1X9ZA 3TSZA 2DLSA 5HEBA 4NMTA 1TP5A 1TE0A 2Z9IA 2W4FA 1QAUA 3B76A 4Q2NA 5FB8C 2WL7A 4NXRA 4YDPA 2FCFA 2JREA 2HE2A 2I1NA 4REYA 2JINA 1QLCA 3LNYA 2EDVA 2RRMA 5HFBA 2DJTA 2QG1A 1GQ4A 3FY5A 2I0LA 3OTPA 3GDVA 4JOPA 2KQFA 5HEDA 1PDRA 3BPUA 1TP3A 2FN5A 1Y7NA 2ZPMA 2KOHA 2I0IA 2EEIA 2DLUA 4OEOA 2VSVA 2YTWA 2M0VA 2KA9A 2F5YA 4Q2OA 4JOFA 2OSGA 2YT8A 4JOGA 2G5MB 3PV5A 1SOZA 2AINA 2I6VA 3CBYA 4NMVA 4AMHA 5F3XA 3TSWA 4IC6A 2KL1A
chains in the Genus database with same CATH topology
4JOKA 2OMJA 4P2AB 3O46A 1X5QA 1WG6A 2OPGA 3ZRTA 3STJA 2QT5A 2R4HA 3NCVA 1UEQA 3TSVA 3CBZA 1VB7A 4WYUA 2I04A 1B8QA 2YUYA 1N99A 4UU5A 1U38A 1WIFA 3CC0A 1TQ3A 4JOJA 2LC6A 2X7ZA 1N7EA 2KG2A 2K20A 1FC7A 1P1EA 2EDPA 5B6LA 5G1EA 5E21A 2LC7A 1KY9A 2ZPLA 2D8IA 4KFVA 2KBSA 2R3YA 3WKMA 4GVDA 1UEZA 3AXAA 1V1TA 4Z8JA 3HVQC 2FE5A 4K6YA 4MPAA 2IWQA 2L4SA 1IHJA 2EEGA 4HOPA 2MX6A 2H2BA 3GGEA 1UITA 2F0AA 2L97A 2M10A 2D92A 2EGNA 1OBXA 4L8NA 2EJYA 3WKLA 2EEHA 2PKUA 1UJDA 4K72A 1WJLA 1GM1A 2KJDA 2O2TA 1NF3C 4OEPA 2IWOA 2H2CA 2EGOA 4NMSA 2VWRA 4KFWA 3MH7A 3MH4A 4E34A 3SHUA 1D5GA 1NTEA 4N6XA 4R2ZA 4Q6HA 3CS0A 2W7RA 1KWAA 1FC6A 2KJKA 2K1ZA 2KPKA 3O5NA 1VJ6A 3RL8A 3SUZA 1WFGA 1RY4A 4HOPB 1U3BA 2EHRA 5E1YA 1Q7XA 3QDOA 3DORA 4F8KA 1X6DA 1WF8A 2EEJA 2JOAA 3GCNA 3MH6A 2E7KA 2KRGA 2H3LA 2IWPA 3GDSA 4P0CA 4EDJA 4JOHA 2AWXA 2VSPA 5A2PA 2EDZA 2UZCA 1WFVA 1I16A 1MFLA 1FCFA 1WF7A 1WHDA 2CSJA 2GEFA 4K78A 4NNMA 3ID4A 1N6DA 2M0TA 1IU2A 3HPMA 1UJVA 5D13A 1KEFA 2JIKA 4NMOA 2VPHA 3SHWA 1QAVB 2EGKA 5G1DA 3ID1A 3EGGC 1U37A 3QE1A 5HJ1A 2RCZA 5GNDA 1UHPA 1BFEA 2LA8A 1OBZA 3GCOA 4FGMA 4NXPA 2M3MA 4NMPA 1RGRA 5B42A 1K32A 3HPKA 1X45A 3L4FD 3ID3A 1X8SA 3VQGA 4WYTA 2QKUA 4JJ0A 2V1WA 5HFEA 2JILA 5E11A 1GQ5A 1V5QA 1SOTA 2JXOA 1V6BA 1W9QA 5F67A 3SOEA 1VCWA 2Z17A 2M0UA 5JXBA 2CSSA 2CS5A 1FC9A 5HFFA 2EXGA 3OU0A 1X5RA 1VA8A 1N6FA 3GJ9A 1UJUA 1ZOKA 2V90A 2AWWA 5HF1A 1YBOA 2DMZA 2VRFA 4JL7A 5HF4A 1VAEA 1RZXA 1V5LA 3VQFA 1Q3OA 1T2MA 2D90A 3NFLA 2IWNA 1L6OA 2PZDA 4XHVA 1M5ZA 1UEPA 2PDZA 4JOEA 5HFDA 2HGAA 2PA1A 1MFGA 1W9OA 2DC2A 3DJAA 3TMHA 3E17A 2YT7A 4NMRA 4E35A 3PV4A 2JSNA 2KJPA 3ID2A 3DIWA 3I4WA 1UEWA 2DAZA 3KHFA 2M0ZA 5HFCA 4O06A 4FLNA 3I18A 4K75A 2Q3GA 3R0HA 5ILBA 1I92A 5DTHA 5E22A 3NFKA 2QKVA 4E3BA 2JWEA 1QAVA 3QO6A 2I4SA 4JORA 2L4TA 4Q6SA 1Z86A 2LOBA 2KOJA 5GLJA 2OZFA 5E6PB 1WI4A 2OS6A 2DM8A 3QJMA 5HDYA 2P3WA 1WH1A 3PDVA 3RLEA 4NNLA 3DJ1A 2EV8A 1ZUBA 1OBYA 3LNXA 1XZ9A 1WHAA 2H3MA 5HETA 1W9EA 2PKTA 1OZIA 3KDKA 2Q9VA 2REYA 5I7ZA 2VZ5A 3K1RA 3QJNA 3CH8A 1UFXA 4GHNA 3JXTA 3EGHC 1IU0A 1Z87A 4Z33A 1N7TA 3K50A 2LUIA 4NXQA 1G9OA 1WI2A 2OCSA 3SFJA 2G2LA 1Q3PA 2EAQA 1R6JA 2PNTA 4OAJA 3KZEA 2FNEA 4H11A 2KYLA 3PS4A 4K76A 2QKTA 1UF1A 2AWUA 3I1EA 2OGPA 3GSLA 3R69A 4GVCA 2HE4A 1N7FA 4Q3HA 3KDGA 4RI0A 1UM7A 3K82A 2BYGA 1MC7A 1X5NA 3QIKA 3PDZA 5FHTA 1U39A 1RGWA 3R68A 4Q2PA 2ENOA 3NGHA 3CYYA 2YUBA 1Y8TA 3GDUA 3PV2A 4G69A 2QBWA 2KPLA 1BE9A 2OQSA 1LCYA 3DJ3A 5EYZA 4JJ3A 3KZDA 4LMMA 3CBXA 4Q2QA 3GABA 2MHOA 2KOMA 5H3JA 5IL9A 2KV8A 1N6EA 4UU6A 1P1DA 2GZVA 4NMQA 3RL7A 1UM1A 2KAWA 2DB5A 4YYXA 3QGLA 5EZ0A 4PQWA 1V62A 2DKRA 5HEYA 1X9ZA 3TSZA 2DLSA 5HEBA 4NMTA 1TP5A 1TE0A 2Z9IA 2W4FA 1QAUA 3B76A 4Q2NA 5FB8C 2WL7A 4NXRA 4YDPA 2FCFA 2JREA 2HE2A 2I1NA 4REYA 2JINA 1QLCA 3LNYA 2EDVA 2RRMA 5HFBA 2DJTA 2QG1A 1GQ4A 3FY5A 2I0LA 3OTPA 3GDVA 4JOPA 2KQFA 5HEDA 1PDRA 3BPUA 1TP3A 2FN5A 1Y7NA 2ZPMA 2KOHA 2I0IA 2EEIA 2DLUA 4OEOA 2VSVA 2YTWA 2M0VA 2KA9A 2F5YA 4Q2OA 4JOFA 2OSGA 2YT8A 4JOGA 2G5MB 3PV5A 1SOZA 2AINA 2I6VA 3CBYA 4NMVA 4AMHA 5F3XA 3TSWA 4IC6A 2KL1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4JOK A;  2OMJ A;  4P2A B;  3O46 A;  1X5Q A;  1WG6 A;  2OPG A;  3ZRT A;  3STJ A;  2QT5 A;  2R4H A;  1UEQ A;  3TSV A;  3CBZ A;  1VB7 A;  4WYU A;  2I04 A;  1B8Q A;  2YUY A;  1N99 A;  4UU5 A;  1U38 A;  1WIF A;  3CC0 A;  1TQ3 A;  4JOJ A;  2LC6 A;  2X7Z A;  1N7E A;  2KG2 A;  2K20 A;  1FC7 A;  1P1E A;  2EDP A;  5B6L A;  5G1E A;  5E21 A;  2LC7 A;  1KY9 A;  2ZPL A;  2D8I A;  4KFV A;  2KBS A;  2R3Y A;  3WKM A;  4GVD A;  1UEZ A;  3AXA A;  1V1T A;  4Z8J A;  3HVQ C;  2FE5 A;  4K6Y A;  4MPA A;  2IWQ A;  2L4S A;  1IHJ A;  2EEG A;  4HOP A;  2MX6 A;  2H2B A;  3GGE A;  1UIT A;  2F0A A;  2L97 A;  2M10 A;  2D92 A;  2EGN A;  1OBX A;  4L8N A;  2EJY A;  3WKL A;  2EEH A;  2PKU A;  1UJD A;  4K72 A;  1WJL A;  1GM1 A;  2KJD A;  2O2T A;  1NF3 C;  4OEP A;  2IWO A;  2H2C A;  2EGO A;  4NMS A;  2VWR A;  4KFW A;  3MH7 A;  3MH4 A;  4E34 A;  3SHU A;  1D5G A;  1NTE A;  4N6X A;  4R2Z A;  4Q6H A;  3CS0 A;  2W7R A;  1KWA A;  1FC6 A;  2KJK A;  2K1Z A;  2KPK A;  3O5N A;  1VJ6 A;  3RL8 A;  3SUZ A;  1WFG A;  1RY4 A;  4HOP B;  1U3B A;  2EHR A;  5E1Y A;  1Q7X A;  3QDO A;  3DOR A;  4F8K A;  1X6D A;  1WF8 A;  2EEJ A;  2JOA A;  3GCN A;  3MH6 A;  2E7K A;  2KRG A;  2H3L A;  2IWP A;  3GDS A;  4P0C A;  4EDJ A;  4JOH A;  2AWX A;  2VSP A;  5A2P A;  2EDZ A;  2UZC A;  1WFV A;  1I16 A;  1MFL A;  1FCF A;  1WF7 A;  1WHD A;  2CSJ A;  4K78 A;  4NNM A;  3ID4 A;  1N6D A;  2M0T A;  1IU2 A;  3HPM A;  1UJV A;  5D13 A;  1KEF A;  2JIK A;  4NMO A;  2VPH A;  3SHW A;  1QAV B;  2EGK A;  5G1D A;  3ID1 A;  3EGG C;  1U37 A;  3QE1 A;  5HJ1 A;  2RCZ A;  5GND A;  1UHP A;  1BFE A;  2LA8 A;  1OBZ A;  3GCO A;  4FGM A;  4NXP A;  2M3M A;  4NMP A;  1RGR A;  1K32 A;  3HPK A;  1X45 A;  3L4F D;  3ID3 A;  1X8S A;  3VQG A;  4WYT A;  2QKU A;  2V1W A;  5HFE A;  2JIL A;  5E11 A;  1GQ5 A;  1V5Q A;  1SOT A;  2JXO A;  1V6B A;  1W9Q A;  5F67 A;  3SOE A;  1VCW A;  2Z17 A;  2M0U A;  5JXB A;  2CSS A;  2CS5 A;  1FC9 A;  5HFF A;  2EXG A;  3OU0 A;  1X5R A;  1VA8 A;  1N6F A;  3GJ9 A;  1UJU A;  1ZOK A;  2V90 A;  2AWW A;  5HF1 A;  1YBO A;  2DMZ A;  2VRF A;  4JL7 A;  5HF4 A;  1VAE A;  1RZX A;  1V5L A;  3VQF A;  1Q3O A;  1T2M A;  2D90 A;  3NFL A;  2IWN A;  1L6O A;  2PZD A;  4XHV A;  1M5Z A;  1UEP A;  2PDZ A;  4JOE A;  5HFD A;  2HGA A;  2PA1 A;  1MFG A;  1W9O A;  2DC2 A;  3DJA A;  3TMH A;  3E17 A;  2YT7 A;  4NMR A;  4E35 A;  3PV4 A;  2KJP A;  3ID2 A;  3DIW A;  3I4W A;  1UEW A;  2DAZ A;  3KHF A;  2M0Z A;  5HFC A;  4O06 A;  3I18 A;  4K75 A;  2Q3G A;  3R0H A;  1I92 A;  5DTH A;  5E22 A;  3NFK A;  2QKV A;  4E3B A;  2JWE A;  1QAV A;  3QO6 A;  2I4S A;  4JOR A;  2L4T A;  4Q6S A;  1Z86 A;  2LOB A;  2KOJ A;  5GLJ A;  2OZF A;  5E6P B;  1WI4 A;  2OS6 A;  2DM8 A;  3QJM A;  5HDY A;  2P3W A;  1WH1 A;  3PDV A;  3RLE A;  4NNL A;  3DJ1 A;  2EV8 A;  1ZUB A;  1OBY A;  3LNX A;  1XZ9 A;  1WHA A;  2H3M A;  5HET A;  1W9E A;  2PKT A;  1OZI A;  2Q9V A;  2REY A;  5I7Z A;  3K1R A;  2VZ5 A;  3QJN A;  3CH8 A;  1UFX A;  4GHN A;  3JXT A;  3EGH C;  1IU0 A;  1Z87 A;  4Z33 A;  1N7T A;  3K50 A;  2LUI A;  4NXQ A;  1G9O A;  1WI2 A;  2OCS A;  3SFJ A;  2G2L A;  1Q3P A;  2EAQ A;  1R6J A;  2PNT A;  4OAJ A;  3KZE A;  2FNE A;  4H11 A;  2KYL A;  3PS4 A;  4K76 A;  2QKT A;  1UF1 A;  2AWU A;  3I1E A;  2OGP A;  3GSL A;  3R69 A;  4GVC A;  2HE4 A;  1N7F A;  4Q3H A;  4RI0 A;  1UM7 A;  3K82 A;  2BYG A;  1MC7 A;  1X5N A;  3QIK A;  3PDZ A;  5FHT A;  1U39 A;  1RGW A;  3R68 A;  4Q2P A;  2ENO A;  3NGH A;  3CYY A;  2YUB A;  1Y8T A;  3GDU A;  3PV2 A;  4G69 A;  2QBW A;  2KPL A;  1BE9 A;  2OQS A;  1LCY A;  3DJ3 A;  5EYZ A;  3KZD A;  4LMM A;  3CBX A;  4Q2Q A;  2MHO A;  2KOM A;  5H3J A;  2KV8 A;  1N6E A;  4UU6 A;  1P1D A;  2GZV A;  4NMQ A;  3RL7 A;  1UM1 A;  2KAW A;  2DB5 A;  4YYX A;  3QGL A;  5EZ0 A;  4PQW A;  1V62 A;  2DKR A;  5HEY A;  3TSZ A;  2DLS A;  5HEB A;  4NMT A;  1TP5 A;  1TE0 A;  2Z9I A;  2W4F A;  1QAU A;  3B76 A;  4Q2N A;  5FB8 C;  2WL7 A;  4NXR A;  4YDP A;  2FCF A;  2JRE A;  2HE2 A;  2I1N A;  4REY A;  2JIN A;  1QLC A;  3LNY A;  2EDV A;  2RRM A;  5HFB A;  2DJT A;  2QG1 A;  1GQ4 A;  3FY5 A;  2I0L A;  3OTP A;  3GDV A;  4JOP A;  2KQF A;  5HED A;  1PDR A;  3BPU A;  1TP3 A;  2FN5 A;  1Y7N A;  2ZPM A;  2KOH A;  2I0I A;  2EEI A;  2DLU A;  4OEO A;  2VSV A;  2YTW A;  2M0V A;  2KA9 A;  2F5Y A;  4Q2O A;  4JOF A;  2OSG A;  2YT8 A;  4JOG A;  2G5M B;  3PV5 A;  1SOZ A;  2AIN A;  2I6V A;  3CBY A;  4NMV A;  4AMH A;  5F3X A;  3TSW A;  4IC6 A;  2KL1 A; 
#chains in the Genus database with same CATH topology
 4JOK A;  2OMJ A;  4P2A B;  3O46 A;  1X5Q A;  1WG6 A;  2OPG A;  3ZRT A;  3STJ A;  2QT5 A;  2R4H A;  3NCV A;  1UEQ A;  3TSV A;  3CBZ A;  1VB7 A;  4WYU A;  2I04 A;  1B8Q A;  2YUY A;  1N99 A;  4UU5 A;  1U38 A;  1WIF A;  3CC0 A;  1TQ3 A;  4JOJ A;  2LC6 A;  2X7Z A;  1N7E A;  2KG2 A;  2K20 A;  1FC7 A;  1P1E A;  2EDP A;  5B6L A;  5G1E A;  5E21 A;  2LC7 A;  1KY9 A;  2ZPL A;  2D8I A;  4KFV A;  2KBS A;  2R3Y A;  3WKM A;  4GVD A;  1UEZ A;  3AXA A;  1V1T A;  4Z8J A;  3HVQ C;  2FE5 A;  4K6Y A;  4MPA A;  2IWQ A;  2L4S A;  1IHJ A;  2EEG A;  4HOP A;  2MX6 A;  2H2B A;  3GGE A;  1UIT A;  2F0A A;  2L97 A;  2M10 A;  2D92 A;  2EGN A;  1OBX A;  4L8N A;  2EJY A;  3WKL A;  2EEH A;  2PKU A;  1UJD A;  4K72 A;  1WJL A;  1GM1 A;  2KJD A;  2O2T A;  1NF3 C;  4OEP A;  2IWO A;  2H2C A;  2EGO A;  4NMS A;  2VWR A;  4KFW A;  3MH7 A;  3MH4 A;  4E34 A;  3SHU A;  1D5G A;  1NTE A;  4N6X A;  4R2Z A;  4Q6H A;  3CS0 A;  2W7R A;  1KWA A;  1FC6 A;  2KJK A;  2K1Z A;  2KPK A;  3O5N A;  1VJ6 A;  3RL8 A;  3SUZ A;  1WFG A;  1RY4 A;  4HOP B;  1U3B A;  2EHR A;  5E1Y A;  1Q7X A;  3QDO A;  3DOR A;  4F8K A;  1X6D A;  1WF8 A;  2EEJ A;  2JOA A;  3GCN A;  3MH6 A;  2E7K A;  2KRG A;  2H3L A;  2IWP A;  3GDS A;  4P0C A;  4EDJ A;  4JOH A;  2AWX A;  2VSP A;  5A2P A;  2EDZ A;  2UZC A;  1WFV A;  1I16 A;  1MFL A;  1FCF A;  1WF7 A;  1WHD A;  2CSJ A;  2GEF A;  4K78 A;  4NNM A;  3ID4 A;  1N6D A;  2M0T A;  1IU2 A;  3HPM A;  1UJV A;  5D13 A;  1KEF A;  2JIK A;  4NMO A;  2VPH A;  3SHW A;  1QAV B;  2EGK A;  5G1D A;  3ID1 A;  3EGG C;  1U37 A;  3QE1 A;  5HJ1 A;  2RCZ A;  5GND A;  1UHP A;  1BFE A;  2LA8 A;  1OBZ A;  3GCO A;  4FGM A;  4NXP A;  2M3M A;  4NMP A;  1RGR A;  5B42 A;  1K32 A;  3HPK A;  1X45 A;  3L4F D;  3ID3 A;  1X8S A;  3VQG A;  4WYT A;  2QKU A;  4JJ0 A;  2V1W A;  5HFE A;  2JIL A;  5E11 A;  1GQ5 A;  1V5Q A;  1SOT A;  2JXO A;  1V6B A;  1W9Q A;  5F67 A;  3SOE A;  1VCW A;  2Z17 A;  2M0U A;  5JXB A;  2CSS A;  2CS5 A;  1FC9 A;  5HFF A;  2EXG A;  3OU0 A;  1X5R A;  1VA8 A;  1N6F A;  3GJ9 A;  1UJU A;  1ZOK A;  2V90 A;  2AWW A;  5HF1 A;  1YBO A;  2DMZ A;  2VRF A;  4JL7 A;  5HF4 A;  1VAE A;  1RZX A;  1V5L A;  3VQF A;  1Q3O A;  1T2M A;  2D90 A;  3NFL A;  2IWN A;  1L6O A;  2PZD A;  4XHV A;  1M5Z A;  1UEP A;  2PDZ A;  4JOE A;  5HFD A;  2HGA A;  2PA1 A;  1MFG A;  1W9O A;  2DC2 A;  3DJA A;  3TMH A;  3E17 A;  2YT7 A;  4NMR A;  4E35 A;  3PV4 A;  2JSN A;  2KJP A;  3ID2 A;  3DIW A;  3I4W A;  1UEW A;  2DAZ A;  3KHF A;  2M0Z A;  5HFC A;  4O06 A;  4FLN A;  3I18 A;  4K75 A;  2Q3G A;  3R0H A;  5ILB A;  1I92 A;  5DTH A;  5E22 A;  3NFK A;  2QKV A;  4E3B A;  2JWE A;  1QAV A;  3QO6 A;  2I4S A;  4JOR A;  2L4T A;  4Q6S A;  1Z86 A;  2LOB A;  2KOJ A;  5GLJ A;  2OZF A;  5E6P B;  1WI4 A;  2OS6 A;  2DM8 A;  3QJM A;  5HDY A;  2P3W A;  1WH1 A;  3PDV A;  3RLE A;  4NNL A;  3DJ1 A;  2EV8 A;  1ZUB A;  1OBY A;  3LNX A;  1XZ9 A;  1WHA A;  2H3M A;  5HET A;  1W9E A;  2PKT A;  1OZI A;  3KDK A;  2Q9V A;  2REY A;  5I7Z A;  2VZ5 A;  3K1R A;  3QJN A;  3CH8 A;  1UFX A;  4GHN A;  3JXT A;  3EGH C;  1IU0 A;  1Z87 A;  4Z33 A;  1N7T A;  3K50 A;  2LUI A;  4NXQ A;  1G9O A;  1WI2 A;  2OCS A;  3SFJ A;  2G2L A;  1Q3P A;  2EAQ A;  1R6J A;  2PNT A;  4OAJ A;  3KZE A;  2FNE A;  4H11 A;  2KYL A;  3PS4 A;  4K76 A;  2QKT A;  1UF1 A;  2AWU A;  3I1E A;  2OGP A;  3GSL A;  3R69 A;  4GVC A;  2HE4 A;  1N7F A;  4Q3H A;  3KDG A;  4RI0 A;  1UM7 A;  3K82 A;  2BYG A;  1MC7 A;  1X5N A;  3QIK A;  3PDZ A;  5FHT A;  1U39 A;  1RGW A;  3R68 A;  4Q2P A;  2ENO A;  3NGH A;  3CYY A;  2YUB A;  1Y8T A;  3GDU A;  3PV2 A;  4G69 A;  2QBW A;  2KPL A;  1BE9 A;  2OQS A;  1LCY A;  3DJ3 A;  5EYZ A;  4JJ3 A;  3KZD A;  4LMM A;  3CBX A;  4Q2Q A;  3GAB A;  2MHO A;  2KOM A;  5H3J A;  5IL9 A;  2KV8 A;  1N6E A;  4UU6 A;  1P1D A;  2GZV A;  4NMQ A;  3RL7 A;  1UM1 A;  2KAW A;  2DB5 A;  4YYX A;  3QGL A;  5EZ0 A;  4PQW A;  1V62 A;  2DKR A;  5HEY A;  1X9Z A;  3TSZ A;  2DLS A;  5HEB A;  4NMT A;  1TP5 A;  1TE0 A;  2Z9I A;  2W4F A;  1QAU A;  3B76 A;  4Q2N A;  5FB8 C;  2WL7 A;  4NXR A;  4YDP A;  2FCF A;  2JRE A;  2HE2 A;  2I1N A;  4REY A;  2JIN A;  1QLC A;  3LNY A;  2EDV A;  2RRM A;  5HFB A;  2DJT A;  2QG1 A;  1GQ4 A;  3FY5 A;  2I0L A;  3OTP A;  3GDV A;  4JOP A;  2KQF A;  5HED A;  1PDR A;  3BPU A;  1TP3 A;  2FN5 A;  1Y7N A;  2ZPM A;  2KOH A;  2I0I A;  2EEI A;  2DLU A;  4OEO A;  2VSV A;  2YTW A;  2M0V A;  2KA9 A;  2F5Y A;  4Q2O A;  4JOF A;  2OSG A;  2YT8 A;  4JOG A;  2G5M B;  3PV5 A;  1SOZ A;  2AIN A;  2I6V A;  3CBY A;  4NMV A;  4AMH A;  5F3X A;  3TSW A;  4IC6 A;  2KL1 A; 
#chains in the Genus database with same CATH homology
 4JOK A;  2OMJ A;  4P2A B;  3O46 A;  1X5Q A;  1WG6 A;  2OPG A;  3ZRT A;  3STJ A;  2QT5 A;  2R4H A;  3NCV A;  1UEQ A;  3TSV A;  3CBZ A;  1VB7 A;  4WYU A;  2I04 A;  1B8Q A;  2YUY A;  1N99 A;  4UU5 A;  1U38 A;  1WIF A;  3CC0 A;  1TQ3 A;  4JOJ A;  2LC6 A;  2X7Z A;  1N7E A;  2KG2 A;  2K20 A;  1FC7 A;  1P1E A;  2EDP A;  5B6L A;  5G1E A;  5E21 A;  2LC7 A;  1KY9 A;  2ZPL A;  2D8I A;  4KFV A;  2KBS A;  2R3Y A;  3WKM A;  4GVD A;  1UEZ A;  3AXA A;  1V1T A;  4Z8J A;  3HVQ C;  2FE5 A;  4K6Y A;  4MPA A;  2IWQ A;  2L4S A;  1IHJ A;  2EEG A;  4HOP A;  2MX6 A;  2H2B A;  3GGE A;  1UIT A;  2F0A A;  2L97 A;  2M10 A;  2D92 A;  2EGN A;  1OBX A;  4L8N A;  2EJY A;  3WKL A;  2EEH A;  2PKU A;  1UJD A;  4K72 A;  1WJL A;  1GM1 A;  2KJD A;  2O2T A;  1NF3 C;  4OEP A;  2IWO A;  2H2C A;  2EGO A;  4NMS A;  2VWR A;  4KFW A;  3MH7 A;  3MH4 A;  4E34 A;  3SHU A;  1D5G A;  1NTE A;  4N6X A;  4R2Z A;  4Q6H A;  3CS0 A;  2W7R A;  1KWA A;  1FC6 A;  2KJK A;  2K1Z A;  2KPK A;  3O5N A;  1VJ6 A;  3RL8 A;  3SUZ A;  1WFG A;  1RY4 A;  4HOP B;  1U3B A;  2EHR A;  5E1Y A;  1Q7X A;  3QDO A;  3DOR A;  4F8K A;  1X6D A;  1WF8 A;  2EEJ A;  2JOA A;  3GCN A;  3MH6 A;  2E7K A;  2KRG A;  2H3L A;  2IWP A;  3GDS A;  4P0C A;  4EDJ A;  4JOH A;  2AWX A;  2VSP A;  5A2P A;  2EDZ A;  2UZC A;  1WFV A;  1I16 A;  1MFL A;  1FCF A;  1WF7 A;  1WHD A;  2CSJ A;  2GEF A;  4K78 A;  4NNM A;  3ID4 A;  1N6D A;  2M0T A;  1IU2 A;  3HPM A;  1UJV A;  5D13 A;  1KEF A;  2JIK A;  4NMO A;  2VPH A;  3SHW A;  1QAV B;  2EGK A;  5G1D A;  3ID1 A;  3EGG C;  1U37 A;  3QE1 A;  5HJ1 A;  2RCZ A;  5GND A;  1UHP A;  1BFE A;  2LA8 A;  1OBZ A;  3GCO A;  4FGM A;  4NXP A;  2M3M A;  4NMP A;  1RGR A;  5B42 A;  1K32 A;  3HPK A;  1X45 A;  3L4F D;  3ID3 A;  1X8S A;  3VQG A;  4WYT A;  2QKU A;  4JJ0 A;  2V1W A;  5HFE A;  2JIL A;  5E11 A;  1GQ5 A;  1V5Q A;  1SOT A;  2JXO A;  1V6B A;  1W9Q A;  5F67 A;  3SOE A;  1VCW A;  2Z17 A;  2M0U A;  5JXB A;  2CSS A;  2CS5 A;  1FC9 A;  5HFF A;  2EXG A;  3OU0 A;  1X5R A;  1VA8 A;  1N6F A;  3GJ9 A;  1UJU A;  1ZOK A;  2V90 A;  2AWW A;  5HF1 A;  1YBO A;  2DMZ A;  2VRF A;  4JL7 A;  5HF4 A;  1VAE A;  1RZX A;  1V5L A;  3VQF A;  1Q3O A;  1T2M A;  2D90 A;  3NFL A;  2IWN A;  1L6O A;  2PZD A;  4XHV A;  1M5Z A;  1UEP A;  2PDZ A;  4JOE A;  5HFD A;  2HGA A;  2PA1 A;  1MFG A;  1W9O A;  2DC2 A;  3DJA A;  3TMH A;  3E17 A;  2YT7 A;  4NMR A;  4E35 A;  3PV4 A;  2JSN A;  2KJP A;  3ID2 A;  3DIW A;  3I4W A;  1UEW A;  2DAZ A;  3KHF A;  2M0Z A;  5HFC A;  4O06 A;  4FLN A;  3I18 A;  4K75 A;  2Q3G A;  3R0H A;  5ILB A;  1I92 A;  5DTH A;  5E22 A;  3NFK A;  2QKV A;  4E3B A;  2JWE A;  1QAV A;  3QO6 A;  2I4S A;  4JOR A;  2L4T A;  4Q6S A;  1Z86 A;  2LOB A;  2KOJ A;  5GLJ A;  2OZF A;  5E6P B;  1WI4 A;  2OS6 A;  2DM8 A;  3QJM A;  5HDY A;  2P3W A;  1WH1 A;  3PDV A;  3RLE A;  4NNL A;  3DJ1 A;  2EV8 A;  1ZUB A;  1OBY A;  3LNX A;  1XZ9 A;  1WHA A;  2H3M A;  5HET A;  1W9E A;  2PKT A;  1OZI A;  3KDK A;  2Q9V A;  2REY A;  5I7Z A;  2VZ5 A;  3K1R A;  3QJN A;  3CH8 A;  1UFX A;  4GHN A;  3JXT A;  3EGH C;  1IU0 A;  1Z87 A;  4Z33 A;  1N7T A;  3K50 A;  2LUI A;  4NXQ A;  1G9O A;  1WI2 A;  2OCS A;  3SFJ A;  2G2L A;  1Q3P A;  2EAQ A;  1R6J A;  2PNT A;  4OAJ A;  3KZE A;  2FNE A;  4H11 A;  2KYL A;  3PS4 A;  4K76 A;  2QKT A;  1UF1 A;  2AWU A;  3I1E A;  2OGP A;  3GSL A;  3R69 A;  4GVC A;  2HE4 A;  1N7F A;  4Q3H A;  3KDG A;  4RI0 A;  1UM7 A;  3K82 A;  2BYG A;  1MC7 A;  1X5N A;  3QIK A;  3PDZ A;  5FHT A;  1U39 A;  1RGW A;  3R68 A;  4Q2P A;  2ENO A;  3NGH A;  3CYY A;  2YUB A;  1Y8T A;  3GDU A;  3PV2 A;  4G69 A;  2QBW A;  2KPL A;  1BE9 A;  2OQS A;  1LCY A;  3DJ3 A;  5EYZ A;  4JJ3 A;  3KZD A;  4LMM A;  3CBX A;  4Q2Q A;  3GAB A;  2MHO A;  2KOM A;  5H3J A;  5IL9 A;  2KV8 A;  1N6E A;  4UU6 A;  1P1D A;  2GZV A;  4NMQ A;  3RL7 A;  1UM1 A;  2KAW A;  2DB5 A;  4YYX A;  3QGL A;  5EZ0 A;  4PQW A;  1V62 A;  2DKR A;  5HEY A;  1X9Z A;  3TSZ A;  2DLS A;  5HEB A;  4NMT A;  1TP5 A;  1TE0 A;  2Z9I A;  2W4F A;  1QAU A;  3B76 A;  4Q2N A;  5FB8 C;  2WL7 A;  4NXR A;  4YDP A;  2FCF A;  2JRE A;  2HE2 A;  2I1N A;  4REY A;  2JIN A;  1QLC A;  3LNY A;  2EDV A;  2RRM A;  5HFB A;  2DJT A;  2QG1 A;  1GQ4 A;  3FY5 A;  2I0L A;  3OTP A;  3GDV A;  4JOP A;  2KQF A;  5HED A;  1PDR A;  3BPU A;  1TP3 A;  2FN5 A;  1Y7N A;  2ZPM A;  2KOH A;  2I0I A;  2EEI A;  2DLU A;  4OEO A;  2VSV A;  2YTW A;  2M0V A;  2KA9 A;  2F5Y A;  4Q2O A;  4JOF A;  2OSG A;  2YT8 A;  4JOG A;  2G5M B;  3PV5 A;  1SOZ A;  2AIN A;  2I6V A;  3CBY A;  4NMV A;  4AMH A;  5F3X A;  3TSW A;  4IC6 A;  2KL1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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