1PE4A

Solution structure of toxin cn12 from centruroides noxius alfa scorpion toxin acting on sodium channels. nmr structure
Total Genus 10
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
10
sequence length
67
structure length
67
Chain Sequence
RDGYPLASNGCKFGCSGLGENNPTCNHVCEKKAGSDYGYCYAWTCYCEHVAEGTVLWGDSGTGPCRS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title NMR solution structure of Cn12, a novel peptide from the Mexican scorpion Centruroides noxius with a typical beta-toxin sequence but with alpha-like physiological activity.
pubmed doi rcsb
molecule tags Toxin
molecule keywords Neurotoxin Cn11
total genus 10
structure length 67
sequence length 67
ec nomenclature
pdb deposition date 2003-05-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00537 Toxin_3 Scorpion toxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.30.10 Alpha Beta 2-Layer Sandwich Defensin A-like Knottin, scorpion toxin-like 1pe4A00
1JZBA 2E3GA 1NH5A 1FH3A 1NRBA 2KSKA 3E7RL 1VNBA 1JKZA 1LQHA 1T7AA 2KJAA 1SN1A 2BRZA 5KK4A 5CY0A 1DQ7A 1GPTA 1NE5A 2SN3A 1GPSA 1T0ZA 2LI7A 1B7DA 2N2RA 2ASCA 1VNAA 1ZVEA 1NPIA 1ZVGA 1WMTA 2LR3A 2E3FA 1P00A 1AHOA 1PE4A 1ZYWA 2LY6A 1ZYVA 4AEIA 1WT7A 2KBJA 2LJMA 1LQIA 1OMYA 2E0HA 1L4VA 1T1TA 2YEOA 1WWNA 1TI5A 4AAZA 2N66A 1BMRA 2KYQA 1PX9A 1AYJA 4CQKA 1SN4A 4AB0A 1CHZA 1C56A 2LKBA 2LT8A 2NY9X 4HHFA 2N69A 1SNBA 1ICAA 1MR4A 1PTXA 2KBHA 1ZU3A 1I2UA 2I61A 2NY8X 2LJ7A 4KYPA 1LQQA 2YC1C 1B3CA 1N4NA 1I6FA 1NRAA 4UJ0A 1SEGA 2MZ0A 1T7BA 1BK8A 1BCGA 1JXCA 1OZZA 1ZFUA 2B3CA 3E7UX 1MYNA 2YBRC 4V1DC 1BRZA 2KGQA 2LY5A 1C55A 1JZAA 2A7TA 3PSMA 2ATBA 2KPYA 1CN2A 1I2VA 1DJTA 1ZUTA 1I6GA 1T7EA 4HE7A 2N2QA 2B68A 2KBKA 1P0AA 1KV0A 2M8BB 2GL1A
chains in the Genus database with same CATH superfamily
1JZBA 2E3GA 1NH5A 2QWLA 1FH3A 1NRBA 1NGEA 2KSKA 3E7RL 1VNBA 2MN5A 1LQHA 1T7AA 1JKZA 2GMOA 4HE7A 2KJAA 5AQGA 3FZKA 1SN1A 3QMLA 2BRZA 3QFUA 3IUCA 5AQHA 5KK4A 3A8YA 5CY0A 1S3XA 1DQ7A 3KP1A 1GPTA 3M3ZA 1NE5A 2V7ZA 1BA0A 2SN3A 5AQQA 4H5TA 2D56A 4UAEF 4KBOA 3KP0A 1GPSA 1T0ZA 2LI7A 1B7DA 5AR0A 3D2EB 2N2RA 2ASCA 3L4IA 1VNAA 1ZVEA 1NPIA 1XRSB 1ZVGA 3FZMA 1WMTA 3L56A 2BUPA 2LR3A 5F1XA 3FE1A 2E3FA 1NGHA 1BA1A 1P00A 2QWMA 5AQLA 3SF4D 1K8BA 3LDLA 5AQOA 1HX1A 1KAYA 1AHOA 3AY9A 3D2FB 3KHWA 4H5VA 5AQTA 5BN8A 1NGCA 1PE4A 3KOWA 1ZYWA 2LY6A 5AQNA 1QQOA 1ZYVA 2QWPA 5AQJA 5FPDA 5AQRA 1UGLA 2K35A 1WT7A 1NGDA 4AEIA 2E88A 2KBJA 1NGBA 2LJMA 3D2EA 5AQIA 1LQIA 1OMYA 2E0HA 1L4VA 1NGAA 1T1TA 4H5WA 1NGJA 2QWOA 2YEOA 1WWNA 1TI5A 3GKUA 2N66A 4AAZA 1BMRA 2KYQA 1PX9A 3ATVA 3C7NB 5EVZA 5F0XA 1KAXA 2YIOA 1AYJA 2E2FA 2JDQD 1NGGA 3KC6A 5AQFA 4CQKA 1NGFA 1SN4A 3D2FA 4AB0A 1CHZA 2QXLA 1C56A 1NGIA 4IO8A 3KVGA 5AQZA 5AQWA 2LKBA 5BN9A 5BPLA 2LT8A 3FZHA 4UADE 2NY9X 4HHFA 5AQYA 2N69A 2VY6A 1ATSA 1SNBA 3LDNA 2QW9A 1YUWA 1MR4A 1ICAA 1PTXA 2KBHA 1ZU3A 1I2UA 4FL9A 3QFPA 5AQVA 2I61A 2NY8X 2LJ7A 1DKGD 1HJOA 4KYPA 1LQQA 2YC1C 4GNIA 3LDQA 5EY4A 1B3CA 4UAFE 5AQXA 1N4NA 1I6FA 2E8AA 1NRAA 5EXWA 3C7NA 3L6QA 3ATUA 4UJ0A 4H5RA 3R2VA 5AQUA 2QWQA 1SEGA 2MZ0A 1T7BA 2KHOA 1BUPA 3KOXA 3LDPA 4H5NA 5AQSA 1BK8A 2QWRA 5AQMA 3KOZA 3CQXA 3JXUA 5F2RA 1BCGA 1JXCA 1OZZA 1ZFUA 2B3CA 3E7UX 3HSCA 5BPNA 4HWIA 1MYNA 2YBRC 4V1DC 5AQPA 2MBKA 3FZLA 1BRZA 5FPNA 2KGQA 2LY5A 3KOYA 1ATRA 3FZFA 1HPMA 2YILA 3I33A 1C55A 1JZAA 2A7TA 2YIPA 3PSMA 4FSVA 3CW4A 2ATBA 3LDOA 1KAZA 1QQMA 2KPYA 5BPMA 1CN2A 1I2VA 1DJTA 2G2KA 5FPEA 3QI7A 1POIA 1ZUTA 1I6GA 5EX5A 5FPMA 1T7EA 3BK3C 3GL1A 2N2QA 2B68A 2KBKA 1P0AA 1KV0A 2LN8A 2QWNA 2M8BB 3GDQA 5AQKA 1QQNA 2GL1A
chains in the Genus database with same CATH topology
1JZBA 2E3GA 1NH5A 1FH3A 1NRBA 2KSKA 3E7RL 1VNBA 1JKZA 1LQHA 1T7AA 2KJAA 1SN1A 2BRZA 5KK4A 5CY0A 1DQ7A 1GPTA 1NE5A 2SN3A 1GPSA 1T0ZA 2LI7A 1B7DA 2N2RA 2ASCA 1VNAA 1ZVEA 1NPIA 1ZVGA 1WMTA 2LR3A 2E3FA 1P00A 1AHOA 1PE4A 1ZYWA 2LY6A 1ZYVA 4AEIA 1WT7A 2KBJA 2LJMA 1LQIA 1OMYA 2E0HA 1L4VA 1T1TA 2YEOA 1WWNA 1TI5A 4AAZA 2N66A 1BMRA 2KYQA 1PX9A 1AYJA 4CQKA 1SN4A 4AB0A 1CHZA 1C56A 2LKBA 2LT8A 2NY9X 4HHFA 2N69A 1SNBA 1ICAA 1MR4A 1PTXA 2KBHA 1ZU3A 1I2UA 2I61A 2NY8X 2LJ7A 4KYPA 1LQQA 2YC1C 1B3CA 1N4NA 1I6FA 1NRAA 4UJ0A 1SEGA 2MZ0A 1T7BA 1BK8A 1BCGA 1JXCA 1OZZA 1ZFUA 2B3CA 3E7UX 1MYNA 2YBRC 4V1DC 1BRZA 2KGQA 2LY5A 1C55A 1JZAA 2A7TA 3PSMA 2ATBA 2KPYA 1CN2A 1I2VA 1DJTA 1ZUTA 1I6GA 1T7EA 4HE7A 2N2QA 2B68A 2KBKA 1P0AA 1KV0A 2M8BB 2GL1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JZB A;  2E3G A;  1NH5 A;  1FH3 A;  1NRB A;  2KSK A;  3E7R L;  1VNB A;  1JKZ A;  1LQH A;  1T7A A;  2KJA A;  1SN1 A;  2BRZ A;  5KK4 A;  5CY0 A;  1DQ7 A;  1GPT A;  1NE5 A;  2SN3 A;  1GPS A;  1T0Z A;  2LI7 A;  1B7D A;  2N2R A;  2ASC A;  1VNA A;  1ZVE A;  1NPI A;  1ZVG A;  1WMT A;  2LR3 A;  2E3F A;  1P00 A;  1AHO A;  1PE4 A;  1ZYW A;  2LY6 A;  1ZYV A;  4AEI A;  1WT7 A;  2KBJ A;  2LJM A;  1LQI A;  1OMY A;  2E0H A;  1L4V A;  1T1T A;  2YEO A;  1WWN A;  1TI5 A;  4AAZ A;  2N66 A;  1BMR A;  2KYQ A;  1PX9 A;  1AYJ A;  4CQK A;  1SN4 A;  4AB0 A;  1CHZ A;  1C56 A;  2LKB A;  2LT8 A;  2NY9 X;  4HHF A;  2N69 A;  1SNB A;  1ICA A;  1MR4 A;  1PTX A;  2KBH A;  1ZU3 A;  1I2U A;  2I61 A;  2NY8 X;  2LJ7 A;  4KYP A;  1LQQ A;  2YC1 C;  1B3C A;  1N4N A;  1I6F A;  1NRA A;  4UJ0 A;  1SEG A;  2MZ0 A;  1T7B A;  1BK8 A;  1BCG A;  1JXC A;  1OZZ A;  1ZFU A;  2B3C A;  3E7U X;  1MYN A;  2YBR C;  4V1D C;  1BRZ A;  2KGQ A;  2LY5 A;  1C55 A;  1JZA A;  2A7T A;  3PSM A;  2ATB A;  2KPY A;  1CN2 A;  1I2V A;  1DJT A;  1ZUT A;  1I6G A;  1T7E A;  4HE7 A;  2N2Q A;  2B68 A;  2KBK A;  1P0A A;  1KV0 A;  2M8B B;  2GL1 A; 
#chains in the Genus database with same CATH topology
 1JZB A;  2E3G A;  1NH5 A;  2QWL A;  1FH3 A;  1NRB A;  1NGE A;  2KSK A;  3E7R L;  1VNB A;  2MN5 A;  1LQH A;  1T7A A;  1JKZ A;  2GMO A;  4HE7 A;  2KJA A;  5AQG A;  3FZK A;  1SN1 A;  3QML A;  2BRZ A;  3QFU A;  3IUC A;  5AQH A;  5KK4 A;  3A8Y A;  5CY0 A;  1S3X A;  1DQ7 A;  3KP1 A;  1GPT A;  3M3Z A;  1NE5 A;  2V7Z A;  1BA0 A;  2SN3 A;  5AQQ A;  4H5T A;  2D56 A;  4UAE F;  4KBO A;  3KP0 A;  1GPS A;  1T0Z A;  2LI7 A;  1B7D A;  5AR0 A;  3D2E B;  2N2R A;  2ASC A;  3L4I A;  1VNA A;  1ZVE A;  1NPI A;  1XRS B;  1ZVG A;  3FZM A;  1WMT A;  3L56 A;  2BUP A;  2LR3 A;  5F1X A;  3FE1 A;  2E3F A;  1NGH A;  1BA1 A;  1P00 A;  2QWM A;  5AQL A;  3SF4 D;  1K8B A;  3LDL A;  5AQO A;  1HX1 A;  1KAY A;  1AHO A;  3AY9 A;  3D2F B;  3KHW A;  4H5V A;  5AQT A;  5BN8 A;  1NGC A;  1PE4 A;  3KOW A;  1ZYW A;  2LY6 A;  5AQN A;  1QQO A;  1ZYV A;  2QWP A;  5AQJ A;  5FPD A;  5AQR A;  1UGL A;  2K35 A;  1WT7 A;  1NGD A;  4AEI A;  2E88 A;  2KBJ A;  1NGB A;  2LJM A;  3D2E A;  5AQI A;  1LQI A;  1OMY A;  2E0H A;  1L4V A;  1NGA A;  1T1T A;  4H5W A;  1NGJ A;  2QWO A;  2YEO A;  1WWN A;  1TI5 A;  3GKU A;  2N66 A;  4AAZ A;  1BMR A;  2KYQ A;  1PX9 A;  3ATV A;  3C7N B;  5EVZ A;  5F0X A;  1KAX A;  2YIO A;  1AYJ A;  2E2F A;  2JDQ D;  1NGG A;  3KC6 A;  5AQF A;  4CQK A;  1NGF A;  1SN4 A;  3D2F A;  4AB0 A;  1CHZ A;  2QXL A;  1C56 A;  1NGI A;  4IO8 A;  3KVG A;  5AQZ A;  5AQW A;  2LKB A;  5BN9 A;  5BPL A;  2LT8 A;  3FZH A;  4UAD E;  2NY9 X;  4HHF A;  5AQY A;  2N69 A;  2VY6 A;  1ATS A;  1SNB A;  3LDN A;  2QW9 A;  1YUW A;  1MR4 A;  1ICA A;  1PTX A;  2KBH A;  1ZU3 A;  1I2U A;  4FL9 A;  3QFP A;  5AQV A;  2I61 A;  2NY8 X;  2LJ7 A;  1DKG D;  1HJO A;  4KYP A;  1LQQ A;  2YC1 C;  4GNI A;  3LDQ A;  5EY4 A;  1B3C A;  4UAF E;  5AQX A;  1N4N A;  1I6F A;  2E8A A;  1NRA A;  5EXW A;  3C7N A;  3L6Q A;  3ATU A;  4UJ0 A;  4H5R A;  3R2V A;  5AQU A;  2QWQ A;  1SEG A;  2MZ0 A;  1T7B A;  2KHO A;  1BUP A;  3KOX A;  3LDP A;  4H5N A;  5AQS A;  1BK8 A;  2QWR A;  5AQM A;  3KOZ A;  3CQX A;  3JXU A;  5F2R A;  1BCG A;  1JXC A;  1OZZ A;  1ZFU A;  2B3C A;  3E7U X;  3HSC A;  5BPN A;  4HWI A;  1MYN A;  2YBR C;  4V1D C;  5AQP A;  2MBK A;  3FZL A;  1BRZ A;  5FPN A;  2KGQ A;  2LY5 A;  3KOY A;  1ATR A;  3FZF A;  1HPM A;  2YIL A;  3I33 A;  1C55 A;  1JZA A;  2A7T A;  2YIP A;  3PSM A;  4FSV A;  3CW4 A;  2ATB A;  3LDO A;  1KAZ A;  1QQM A;  2KPY A;  5BPM A;  1CN2 A;  1I2V A;  1DJT A;  2G2K A;  5FPE A;  3QI7 A;  1POI A;  1ZUT A;  1I6G A;  5EX5 A;  5FPM A;  1T7E A;  3BK3 C;  3GL1 A;  2N2Q A;  2B68 A;  2KBK A;  1P0A A;  1KV0 A;  2LN8 A;  2QWN A;  2M8B B;  3GDQ A;  5AQK A;  1QQN A;  2GL1 A; 
#chains in the Genus database with same CATH homology
 1JZB A;  2E3G A;  1NH5 A;  1FH3 A;  1NRB A;  2KSK A;  3E7R L;  1VNB A;  1JKZ A;  1LQH A;  1T7A A;  2KJA A;  1SN1 A;  2BRZ A;  5KK4 A;  5CY0 A;  1DQ7 A;  1GPT A;  1NE5 A;  2SN3 A;  1GPS A;  1T0Z A;  2LI7 A;  1B7D A;  2N2R A;  2ASC A;  1VNA A;  1ZVE A;  1NPI A;  1ZVG A;  1WMT A;  2LR3 A;  2E3F A;  1P00 A;  1AHO A;  1PE4 A;  1ZYW A;  2LY6 A;  1ZYV A;  4AEI A;  1WT7 A;  2KBJ A;  2LJM A;  1LQI A;  1OMY A;  2E0H A;  1L4V A;  1T1T A;  2YEO A;  1WWN A;  1TI5 A;  4AAZ A;  2N66 A;  1BMR A;  2KYQ A;  1PX9 A;  1AYJ A;  4CQK A;  1SN4 A;  4AB0 A;  1CHZ A;  1C56 A;  2LKB A;  2LT8 A;  2NY9 X;  4HHF A;  2N69 A;  1SNB A;  1ICA A;  1MR4 A;  1PTX A;  2KBH A;  1ZU3 A;  1I2U A;  2I61 A;  2NY8 X;  2LJ7 A;  4KYP A;  1LQQ A;  2YC1 C;  1B3C A;  1N4N A;  1I6F A;  1NRA A;  4UJ0 A;  1SEG A;  2MZ0 A;  1T7B A;  1BK8 A;  1BCG A;  1JXC A;  1OZZ A;  1ZFU A;  2B3C A;  3E7U X;  1MYN A;  2YBR C;  4V1D C;  1BRZ A;  2KGQ A;  2LY5 A;  1C55 A;  1JZA A;  2A7T A;  3PSM A;  2ATB A;  2KPY A;  1CN2 A;  1I2V A;  1DJT A;  1ZUT A;  1I6G A;  1T7E A;  4HE7 A;  2N2Q A;  2B68 A;  2KBK A;  1P0A A;  1KV0 A;  2M8B B;  2GL1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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