2I61A

Depressant anti-insect neurotoxin, lqhit2 from leiurus quinquestriatus hebraeus
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
62
structure length
62
Chain Sequence
MDGYIKRRDGCKVACLIGNEGCDKECKAYGGSYGYCWTWGLACWCEGLPDDKTWKSETNTCG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-ray Structure and Mutagenesis of the Scorpion Depressant Toxin LqhIT2 Reveals Key Determinants Crucial for Activity and Anti-Insect Selectivity.
pubmed doi rcsb
molecule keywords Insect toxin 2
molecule tags Toxin
source organism Leiurus quinquestriatus hebraeus
total genus 15
structure length 62
sequence length 62
ec nomenclature
pdb deposition date 2006-08-27
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.30.10 Alpha Beta 2-Layer Sandwich Defensin A-like Knottin, scorpion toxin-like 2i61A00
1T1TA 1T7AA 1NRBA 1OZZA 4AEIA 1BK8A 2NY8X 1VNAA 1JZAA 1ZVEA 1LQIA 1I6FA 2ATBA 2KBKA 1ZVGA 1WMTA 1WT7A 1C56A 1JKZA 2NY9X 1VNBA 2KYQA 4AAZA 2KSKA 2YEOA 1I2UA 1AHOA 4HE7A 2LI7A 1GPSA 3PSMA 1T7EA 1ZFUA 1ZYVA 1FH3A 2E0HA 2ASCA 1WWNA 2B3CA 1SEGA 1SN4A 2KGQA 1CHZA 1BCGA 4HHFA 1JZBA 1P0AA 1PE4A 2B68A 1B3CA 2BRZA 1ZU3A 2GL1A 2E3FA 1MR4A 1B7DA 1JXCA 2LR3A 3E7UX 1SN1A 1BMRA 1AYJA 1DJTA 2LY6A 2SN3A 1CN2A 1ZYWA 1TI5A 1LQQA 1I2VA 2YC1C 1MYNA 1OMYA 2N66A 2I61A 2A7TA 1C55A 5CY0A 1N4NA 3E7RL 2LJ7A 1PTXA 1SNBA 2KBJA 2KJAA 4V1DC 1NPIA 1NRAA 2E3GA 5KK4A 4KYPA 2YBRC 1KV0A 1PX9A 1ZUTA 2LJMA 4CQKA 4UJ0A 1DQ7A 1T7BA 1L4VA 1NH5A 2N69A 4AB0A 1BRZA 2KBHA 1ICAA 2LT8A 1NE5A 2N2QA 2LY5A 2LKBA 2M8BB 1I6GA 1T0ZA 2N2RA 1GPTA 2MZ0A 2KPYA 1P00A 1LQHA
chains in the Genus database with same CATH superfamily
5AQRA 1T1TA 1T7AA 1NRBA 1OZZA 5AQZA 4AEIA 2BUPA 4UAFE 1BK8A 2NY8X 1VNAA 1JZAA 1ZVEA 3LDQA 4GNIA 1LQIA 1I6FA 3LDLA 2ATBA 1BA0A 2KBKA 5AQOA 1K8BA 1ATRA 1ZVGA 1WMTA 1WT7A 1C56A 1JKZA 2NY9X 1KAYA 2YILA 2MN5A 4FSVA 5AQMA 1HX1A 1VNBA 2KYQA 4H5WA 3KOWA 3HSCA 5AQHA 4AAZA 3D2EA 2KSKA 5FPMA 1NGFA 5BPMA 1NGBA 3BK3C 4UAEF 1S3XA 3CQXA 3FZKA 3L4IA 1XRSB 3FZMA 1NGJA 2YEOA 4H5RA 1I2UA 5F2RA 4H5TA 1AHOA 2KHOA 4HWIA 3D2FB 4UADE 1QQOA 2QWMA 3LDOA 3QFPA 5F0XA 1NGAA 4HE7A 2LI7A 1GPSA 3PSMA 2QWOA 1T7EA 2E8AA 1ZYVA 5FPEA 5BN8A 4H5NA 3GDQA 5AQUA 1FH3A 3ATUA 2E0HA 2ASCA 1WWNA 2B3CA 1SEGA 1SN4A 2KGQA 1CHZA 1UGLA 2QWQA 5BPLA 5EX5A 1BCGA 2D56A 4KBOA 2E2FA 1POIA 4HHFA 1JZBA 2GMOA 3LDNA 1NGCA 3KHWA 3FZLA 3R2VA 1P0AA 2MBKA 3LDPA 5AQSA 3AY9A 5AQVA 1PE4A 2B68A 5AQLA 1B3CA 2BRZA 1ZU3A 3GL1A 3KOXA 5F1XA 3D2EB 2GL1A 2E3FA 1MR4A 5AQWA 1B7DA 1JXCA 3C7NA 1NGHA 1LQHA 3IUCA 2V7ZA 3KOZA 2LR3A 3KP1A 3CW4A 3KC6A 5AQNA 2VY6A 3E7UX 2QWLA 5AR0A 1SN1A 5AQJA 1BMRA 2QWRA 1DJTA 2LY6A 1AYJA 2SN3A 3QFUA 1CN2A 1ZYWA 5EXWA 3FZHA 1YUWA 2K35A 1TI5A 1LQQA 1I2VA 1NGDA 2YC1C 1MYNA 3KOYA 1NGGA 3I33A 1OMYA 4IO8A 2N66A 2I61A 2QXLA 1QQNA 2A7TA 4FL9A 3FZFA 3QI7A 3SF4D 3GKUA 1C55A 2G2KA 3M3ZA 1N4NA 3E7RL 2LJ7A 2LN8A 3L6QA 3KP0A 5AQTA 5CY0A 1PTXA 1KAXA 5AQIA 1SNBA 2KBJA 2KJAA 2QWNA 2YIOA 4V1DC 1NPIA 1NRAA 5AQQA 2E88A 1NGEA 2E3GA 2QW9A 3QMLA 4H5VA 1QQMA 5AQXA 4KYPA 5FPNA 5KK4A 2YBRC 5BN9A 5EVZA 1KV0A 1ATSA 2JDQD 1PX9A 1ZUTA 2LJMA 3KVGA 4CQKA 4UJ0A 1DQ7A 3JXUA 1T7BA 3C7NB 1DKGD 5EY4A 2YIPA 1HJOA 1L4VA 1NH5A 2N69A 5AQKA 5BPNA 3L56A 2QWPA 5AQPA 4AB0A 1BRZA 2KBHA 1ICAA 2LT8A 5AQFA 1NE5A 2N2QA 3FE1A 2LY5A 3A8YA 2LKBA 1BA1A 1HPMA 5FPDA 2M8BB 1I6GA 1T0ZA 2N2RA 1NGIA 5AQYA 1BUPA 1GPTA 5AQGA 1KAZA 2MZ0A 3ATVA 3D2FA 2KPYA 1P00A 1ZFUA
chains in the Genus database with same CATH topology
1T1TA 1T7AA 1NRBA 1OZZA 4AEIA 1BK8A 2NY8X 1VNAA 1JZAA 1ZVEA 1LQIA 1I6FA 2ATBA 2KBKA 1ZVGA 1WMTA 1WT7A 1C56A 1JKZA 2NY9X 1VNBA 2KYQA 4AAZA 2KSKA 2YEOA 1I2UA 1AHOA 4HE7A 2LI7A 1GPSA 3PSMA 1T7EA 1ZFUA 1ZYVA 1FH3A 2E0HA 2ASCA 1WWNA 2B3CA 1SEGA 1SN4A 2KGQA 1CHZA 1BCGA 4HHFA 1JZBA 1P0AA 1PE4A 2B68A 1B3CA 2BRZA 1ZU3A 2GL1A 2E3FA 1MR4A 1B7DA 1JXCA 2LR3A 3E7UX 1SN1A 1BMRA 1AYJA 1DJTA 2LY6A 2SN3A 1CN2A 1ZYWA 1TI5A 1LQQA 1I2VA 2YC1C 1MYNA 1OMYA 2N66A 2I61A 2A7TA 1C55A 5CY0A 1N4NA 3E7RL 2LJ7A 1PTXA 1SNBA 2KBJA 2KJAA 4V1DC 1NPIA 1NRAA 2E3GA 5KK4A 4KYPA 2YBRC 1KV0A 1PX9A 1ZUTA 2LJMA 4CQKA 4UJ0A 1DQ7A 1T7BA 1L4VA 1NH5A 2N69A 4AB0A 1BRZA 2KBHA 1ICAA 2LT8A 1NE5A 2N2QA 2LY5A 2LKBA 2M8BB 1I6GA 1T0ZA 2N2RA 1GPTA 2MZ0A 2KPYA 1P00A 1LQHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1T1T A;  1T7A A;  1NRB A;  1OZZ A;  4AEI A;  1BK8 A;  2NY8 X;  1VNA A;  1JZA A;  1ZVE A;  1LQI A;  1I6F A;  2ATB A;  2KBK A;  1ZVG A;  1WMT A;  1WT7 A;  1C56 A;  1JKZ A;  2NY9 X;  1VNB A;  2KYQ A;  4AAZ A;  2KSK A;  2YEO A;  1I2U A;  1AHO A;  4HE7 A;  2LI7 A;  1GPS A;  3PSM A;  1T7E A;  1ZFU A;  1ZYV A;  1FH3 A;  2E0H A;  2ASC A;  1WWN A;  2B3C A;  1SEG A;  1SN4 A;  2KGQ A;  1CHZ A;  1BCG A;  4HHF A;  1JZB A;  1P0A A;  1PE4 A;  2B68 A;  1B3C A;  2BRZ A;  1ZU3 A;  2GL1 A;  2E3F A;  1MR4 A;  1B7D A;  1JXC A;  2LR3 A;  3E7U X;  1SN1 A;  1BMR A;  1AYJ A;  1DJT A;  2LY6 A;  2SN3 A;  1CN2 A;  1ZYW A;  1TI5 A;  1LQQ A;  1I2V A;  2YC1 C;  1MYN A;  1OMY A;  2N66 A;  2I61 A;  2A7T A;  1C55 A;  5CY0 A;  1N4N A;  3E7R L;  2LJ7 A;  1PTX A;  1SNB A;  2KBJ A;  2KJA A;  4V1D C;  1NPI A;  1NRA A;  2E3G A;  5KK4 A;  4KYP A;  2YBR C;  1KV0 A;  1PX9 A;  1ZUT A;  2LJM A;  4CQK A;  4UJ0 A;  1DQ7 A;  1T7B A;  1L4V A;  1NH5 A;  2N69 A;  4AB0 A;  1BRZ A;  2KBH A;  1ICA A;  2LT8 A;  1NE5 A;  2N2Q A;  2LY5 A;  2LKB A;  2M8B B;  1I6G A;  1T0Z A;  2N2R A;  1GPT A;  2MZ0 A;  2KPY A;  1P00 A;  1LQH A; 
#chains in the Genus database with same CATH topology
 5AQR A;  1T1T A;  1T7A A;  1NRB A;  1OZZ A;  5AQZ A;  4AEI A;  2BUP A;  4UAF E;  1BK8 A;  2NY8 X;  1VNA A;  1JZA A;  1ZVE A;  3LDQ A;  4GNI A;  1LQI A;  1I6F A;  3LDL A;  2ATB A;  1BA0 A;  2KBK A;  5AQO A;  1K8B A;  1ATR A;  1ZVG A;  1WMT A;  1WT7 A;  1C56 A;  1JKZ A;  2NY9 X;  1KAY A;  2YIL A;  2MN5 A;  4FSV A;  5AQM A;  1HX1 A;  1VNB A;  2KYQ A;  4H5W A;  3KOW A;  3HSC A;  5AQH A;  4AAZ A;  3D2E A;  2KSK A;  5FPM A;  1NGF A;  5BPM A;  1NGB A;  3BK3 C;  4UAE F;  1S3X A;  3CQX A;  3FZK A;  3L4I A;  1XRS B;  3FZM A;  1NGJ A;  2YEO A;  4H5R A;  1I2U A;  5F2R A;  4H5T A;  1AHO A;  2KHO A;  4HWI A;  3D2F B;  4UAD E;  1QQO A;  2QWM A;  3LDO A;  3QFP A;  5F0X A;  1NGA A;  4HE7 A;  2LI7 A;  1GPS A;  3PSM A;  2QWO A;  1T7E A;  2E8A A;  1ZYV A;  5FPE A;  5BN8 A;  4H5N A;  3GDQ A;  5AQU A;  1FH3 A;  3ATU A;  2E0H A;  2ASC A;  1WWN A;  2B3C A;  1SEG A;  1SN4 A;  2KGQ A;  1CHZ A;  1UGL A;  2QWQ A;  5BPL A;  5EX5 A;  1BCG A;  2D56 A;  4KBO A;  2E2F A;  1POI A;  4HHF A;  1JZB A;  2GMO A;  3LDN A;  1NGC A;  3KHW A;  3FZL A;  3R2V A;  1P0A A;  2MBK A;  3LDP A;  5AQS A;  3AY9 A;  5AQV A;  1PE4 A;  2B68 A;  5AQL A;  1B3C A;  2BRZ A;  1ZU3 A;  3GL1 A;  3KOX A;  5F1X A;  3D2E B;  2GL1 A;  2E3F A;  1MR4 A;  5AQW A;  1B7D A;  1JXC A;  3C7N A;  1NGH A;  1LQH A;  3IUC A;  2V7Z A;  3KOZ A;  2LR3 A;  3KP1 A;  3CW4 A;  3KC6 A;  5AQN A;  2VY6 A;  3E7U X;  2QWL A;  5AR0 A;  1SN1 A;  5AQJ A;  1BMR A;  2QWR A;  1DJT A;  2LY6 A;  1AYJ A;  2SN3 A;  3QFU A;  1CN2 A;  1ZYW A;  5EXW A;  3FZH A;  1YUW A;  2K35 A;  1TI5 A;  1LQQ A;  1I2V A;  1NGD A;  2YC1 C;  1MYN A;  3KOY A;  1NGG A;  3I33 A;  1OMY A;  4IO8 A;  2N66 A;  2I61 A;  2QXL A;  1QQN A;  2A7T A;  4FL9 A;  3FZF A;  3QI7 A;  3SF4 D;  3GKU A;  1C55 A;  2G2K A;  3M3Z A;  1N4N A;  3E7R L;  2LJ7 A;  2LN8 A;  3L6Q A;  3KP0 A;  5AQT A;  5CY0 A;  1PTX A;  1KAX A;  5AQI A;  1SNB A;  2KBJ A;  2KJA A;  2QWN A;  2YIO A;  4V1D C;  1NPI A;  1NRA A;  5AQQ A;  2E88 A;  1NGE A;  2E3G A;  2QW9 A;  3QML A;  4H5V A;  1QQM A;  5AQX A;  4KYP A;  5FPN A;  5KK4 A;  2YBR C;  5BN9 A;  5EVZ A;  1KV0 A;  1ATS A;  2JDQ D;  1PX9 A;  1ZUT A;  2LJM A;  3KVG A;  4CQK A;  4UJ0 A;  1DQ7 A;  3JXU A;  1T7B A;  3C7N B;  1DKG D;  5EY4 A;  2YIP A;  1HJO A;  1L4V A;  1NH5 A;  2N69 A;  5AQK A;  5BPN A;  3L56 A;  2QWP A;  5AQP A;  4AB0 A;  1BRZ A;  2KBH A;  1ICA A;  2LT8 A;  5AQF A;  1NE5 A;  2N2Q A;  3FE1 A;  2LY5 A;  3A8Y A;  2LKB A;  1BA1 A;  1HPM A;  5FPD A;  2M8B B;  1I6G A;  1T0Z A;  2N2R A;  1NGI A;  5AQY A;  1BUP A;  1GPT A;  5AQG A;  1KAZ A;  2MZ0 A;  3ATV A;  3D2F A;  2KPY A;  1P00 A;  1ZFU A; 
#chains in the Genus database with same CATH homology
 1T1T A;  1T7A A;  1NRB A;  1OZZ A;  4AEI A;  1BK8 A;  2NY8 X;  1VNA A;  1JZA A;  1ZVE A;  1LQI A;  1I6F A;  2ATB A;  2KBK A;  1ZVG A;  1WMT A;  1WT7 A;  1C56 A;  1JKZ A;  2NY9 X;  1VNB A;  2KYQ A;  4AAZ A;  2KSK A;  2YEO A;  1I2U A;  1AHO A;  4HE7 A;  2LI7 A;  1GPS A;  3PSM A;  1T7E A;  1ZFU A;  1ZYV A;  1FH3 A;  2E0H A;  2ASC A;  1WWN A;  2B3C A;  1SEG A;  1SN4 A;  2KGQ A;  1CHZ A;  1BCG A;  4HHF A;  1JZB A;  1P0A A;  1PE4 A;  2B68 A;  1B3C A;  2BRZ A;  1ZU3 A;  2GL1 A;  2E3F A;  1MR4 A;  1B7D A;  1JXC A;  2LR3 A;  3E7U X;  1SN1 A;  1BMR A;  1AYJ A;  1DJT A;  2LY6 A;  2SN3 A;  1CN2 A;  1ZYW A;  1TI5 A;  1LQQ A;  1I2V A;  2YC1 C;  1MYN A;  1OMY A;  2N66 A;  2I61 A;  2A7T A;  1C55 A;  5CY0 A;  1N4N A;  3E7R L;  2LJ7 A;  1PTX A;  1SNB A;  2KBJ A;  2KJA A;  4V1D C;  1NPI A;  1NRA A;  2E3G A;  5KK4 A;  4KYP A;  2YBR C;  1KV0 A;  1PX9 A;  1ZUT A;  2LJM A;  4CQK A;  4UJ0 A;  1DQ7 A;  1T7B A;  1L4V A;  1NH5 A;  2N69 A;  4AB0 A;  1BRZ A;  2KBH A;  1ICA A;  2LT8 A;  1NE5 A;  2N2Q A;  2LY5 A;  2LKB A;  2M8B B;  1I6G A;  1T0Z A;  2N2R A;  1GPT A;  2MZ0 A;  2KPY A;  1P00 A;  1LQH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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