1PX9A

Solution structure of the native cnerg1 ergtoxin, a highly specific inhibitor of herg channel
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
42
structure length
42
Chain Sequence
DRDSCVDKSRCAKYGYYQECQDCCKNAGHNGGTCMFFKCKCA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K+ channels.
pubmed doi rcsb
molecule tags Toxin
molecule keywords ergtoxin
total genus 13
structure length 42
sequence length 42
ec nomenclature
pdb deposition date 2003-07-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF08086 Toxin_17 Ergtoxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.30.10 Alpha Beta 2-Layer Sandwich Defensin A-like Knottin, scorpion toxin-like 1px9A00
4AAZA 1BK8A 1BCGA 1PE4A 1FH3A 4KYPA 1T0ZA 4UJ0A 2B3CA 1MR4A 2E0HA 2LY5A 1C55A 1ICAA 2N2RA 4CQKA 2GL1A 1I6GA 1NPIA 1KV0A 1T7AA 1NRAA 1DJTA 2LI7A 1VNBA 4AEIA 1JZAA 1I2UA 1WT7A 4HHFA 2KBKA 2B68A 1NE5A 1B7DA 1NRBA 1SN4A 4AB0A 1ZYVA 1T1TA 1P00A 1AHOA 1SNBA 1BMRA 2LKBA 2LJ7A 2KJAA 1GPSA 2A7TA 1ZVEA 2LY6A 1PTXA 1WMTA 1P0AA 2ATBA 2SN3A 3E7RL 4HE7A 1LQQA 1DQ7A 5KK4A 1OMYA 1JXCA 2KSKA 1C56A 4V1DC 2NY9X 2ASCA 3E7UX 1MYNA 1JZBA 1SN1A 1WWNA 1ZUTA 1VNAA 2M8BB 2KYQA 1AYJA 1NH5A 2KBHA 3PSMA 1BRZA 1JKZA 1OZZA 2BRZA 2N69A 5CY0A 1T7EA 1B3CA 1PX9A 2YBRC 2MZ0A 1N4NA 1I2VA 2LR3A 2N2QA 1CN2A 1ZFUA 1SEGA 2NY8X 1TI5A 1T7BA 1ZYWA 1GPTA 1ZU3A 1LQHA 2LT8A 2I61A 2LJMA 2KGQA 2YEOA 1LQIA 2YC1C 2E3FA 1I6FA 1CHZA 1ZVGA 2KBJA 2N66A 2KPYA 1L4VA 2E3GA
chains in the Genus database with same CATH superfamily
3ATVA 3CQXA 4AAZA 1BK8A 1BCGA 1PE4A 1FH3A 5AQYA 5AQIA 4KYPA 1T0ZA 2VY6A 3L4IA 2QWPA 4FSVA 4UJ0A 2B3CA 5EX5A 1KAYA 3AY9A 3C7NB 1MR4A 2E0HA 2LY5A 1C55A 5AQZA 4FL9A 3KC6A 3QFPA 2QWOA 5AR0A 1ICAA 2YIOA 2E88A 2N2RA 5AQRA 4CQKA 3D2EA 1POIA 2GL1A 1I6GA 1NPIA 3D2FA 3FZFA 2YILA 1KV0A 5F1XA 1HJOA 5AQTA 5AQPA 3KVGA 1ATRA 1NGEA 1NRAA 1T7AA 2YIPA 2LI7A 3LDNA 1VNBA 4UAFE 5AQLA 5F0XA 1I2UA 4AEIA 1JZAA 3FZHA 1KAXA 1WT7A 2KBKA 3LDQA 2B68A 4HHFA 2E8AA 2QW9A 1NE5A 1B7DA 1NRBA 1SN4A 2E2FA 4AB0A 1NGCA 1ZYVA 5FPEA 1T1TA 2MBKA 3L56A 1K8BA 3KOXA 2GMOA 5BPLA 1P00A 1AHOA 5AQOA 1SNBA 4GNIA 1ATSA 3L6QA 5AQNA 1BMRA 2LKBA 1NGGA 2LJ7A 3ATUA 3GKUA 2KJAA 1GPSA 2A7TA 1QQNA 1ZVEA 2LY6A 1PTXA 5AQVA 5AQMA 1WMTA 3A8YA 2E3GA 5AQQA 2QWNA 2MN5A 4H5WA 1P0AA 1UGLA 2ATBA 2SN3A 2QWLA 3KOZA 3E7RL 4HE7A 5FPNA 1LQQA 2LN8A 1DQ7A 1NGJA 4HWIA 4H5NA 5AQGA 5AQXA 1HPMA 2K35A 3IUCA 1DKGD 5KK4A 1OMYA 5BPNA 1JXCA 3CW4A 1QQOA 2KSKA 4KBOA 3QI7A 1C56A 4V1DC 2NY9X 2ASCA 1HX1A 3E7UX 5AQFA 3C7NA 3FE1A 3KOYA 1MYNA 3LDPA 3I33A 5EY4A 1JZBA 2QXLA 1SN1A 5AQUA 1NGAA 1BA1A 5FPMA 1WWNA 3QMLA 3R2VA 1ZUTA 1VNAA 3KP1A 2M8BB 3KOWA 3QFUA 5BN9A 2KYQA 5AQWA 1NGFA 1YUWA 3KP0A 1AYJA 1NH5A 2KBHA 3PSMA 1BRZA 2D56A 3FZMA 1JKZA 1OZZA 2BRZA 1S3XA 2N69A 3KHWA 2QWRA 4H5RA 1NGDA 5EXWA 5CY0A 1T7EA 5BN8A 5BPMA 1B3CA 3GL1A 3D2EB 1BUPA 1PX9A 3D2FB 2YBRC 2MZ0A 1N4NA 3M3ZA 4H5VA 4H5TA 2LR3A 4UAEF 1I2VA 1KAZA 2JDQD 4IO8A 2N2QA 1CN2A 1QQMA 2QWQA 2QWMA 5EVZA 1ZFUA 5AQKA 1SEGA 5AQHA 2NY8X 2KHOA 3GDQA 1TI5A 1T7BA 3HSCA 1ZYWA 2BUPA 2V7ZA 5AQSA 5AQJA 1XRSB 3BK3C 3LDLA 1ZU3A 4UADE 1GPTA 1LQHA 2LT8A 2I61A 2LJMA 2KGQA 1NGIA 5FPDA 1NGHA 2YEOA 1LQIA 2YC1C 3SF4D 2G2KA 5F2RA 2E3FA 3JXUA 1I6FA 1CHZA 1ZVGA 2KBJA 2N66A 1NGBA 2KPYA 1BA0A 1L4VA 3LDOA 1DJTA 3FZKA 3FZLA
chains in the Genus database with same CATH topology
4AAZA 1BK8A 1BCGA 1PE4A 1FH3A 4KYPA 1T0ZA 4UJ0A 2B3CA 1MR4A 2E0HA 2LY5A 1C55A 1ICAA 2N2RA 4CQKA 2GL1A 1I6GA 1NPIA 1KV0A 1T7AA 1NRAA 1DJTA 2LI7A 1VNBA 4AEIA 1JZAA 1I2UA 1WT7A 4HHFA 2KBKA 2B68A 1NE5A 1B7DA 1NRBA 1SN4A 4AB0A 1ZYVA 1T1TA 1P00A 1AHOA 1SNBA 1BMRA 2LKBA 2LJ7A 2KJAA 1GPSA 2A7TA 1ZVEA 2LY6A 1PTXA 1WMTA 1P0AA 2ATBA 2SN3A 3E7RL 4HE7A 1LQQA 1DQ7A 5KK4A 1OMYA 1JXCA 2KSKA 1C56A 4V1DC 2NY9X 2ASCA 3E7UX 1MYNA 1JZBA 1SN1A 1WWNA 1ZUTA 1VNAA 2M8BB 2KYQA 1AYJA 1NH5A 2KBHA 3PSMA 1BRZA 1JKZA 1OZZA 2BRZA 2N69A 5CY0A 1T7EA 1B3CA 1PX9A 2YBRC 2MZ0A 1N4NA 1I2VA 2LR3A 2N2QA 1CN2A 1ZFUA 1SEGA 2NY8X 1TI5A 1T7BA 1ZYWA 1GPTA 1ZU3A 1LQHA 2LT8A 2I61A 2LJMA 2KGQA 2YEOA 1LQIA 2YC1C 2E3FA 1I6FA 1CHZA 1ZVGA 2KBJA 2N66A 2KPYA 1L4VA 2E3GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AAZ A;  1BK8 A;  1BCG A;  1PE4 A;  1FH3 A;  4KYP A;  1T0Z A;  4UJ0 A;  2B3C A;  1MR4 A;  2E0H A;  2LY5 A;  1C55 A;  1ICA A;  2N2R A;  4CQK A;  2GL1 A;  1I6G A;  1NPI A;  1KV0 A;  1T7A A;  1NRA A;  1DJT A;  2LI7 A;  1VNB A;  4AEI A;  1JZA A;  1I2U A;  1WT7 A;  4HHF A;  2KBK A;  2B68 A;  1NE5 A;  1B7D A;  1NRB A;  1SN4 A;  4AB0 A;  1ZYV A;  1T1T A;  1P00 A;  1AHO A;  1SNB A;  1BMR A;  2LKB A;  2LJ7 A;  2KJA A;  1GPS A;  2A7T A;  1ZVE A;  2LY6 A;  1PTX A;  1WMT A;  1P0A A;  2ATB A;  2SN3 A;  3E7R L;  4HE7 A;  1LQQ A;  1DQ7 A;  5KK4 A;  1OMY A;  1JXC A;  2KSK A;  1C56 A;  4V1D C;  2NY9 X;  2ASC A;  3E7U X;  1MYN A;  1JZB A;  1SN1 A;  1WWN A;  1ZUT A;  1VNA A;  2M8B B;  2KYQ A;  1AYJ A;  1NH5 A;  2KBH A;  3PSM A;  1BRZ A;  1JKZ A;  1OZZ A;  2BRZ A;  2N69 A;  5CY0 A;  1T7E A;  1B3C A;  1PX9 A;  2YBR C;  2MZ0 A;  1N4N A;  1I2V A;  2LR3 A;  2N2Q A;  1CN2 A;  1ZFU A;  1SEG A;  2NY8 X;  1TI5 A;  1T7B A;  1ZYW A;  1GPT A;  1ZU3 A;  1LQH A;  2LT8 A;  2I61 A;  2LJM A;  2KGQ A;  2YEO A;  1LQI A;  2YC1 C;  2E3F A;  1I6F A;  1CHZ A;  1ZVG A;  2KBJ A;  2N66 A;  2KPY A;  1L4V A;  2E3G A; 
#chains in the Genus database with same CATH topology
 3ATV A;  3CQX A;  4AAZ A;  1BK8 A;  1BCG A;  1PE4 A;  1FH3 A;  5AQY A;  5AQI A;  4KYP A;  1T0Z A;  2VY6 A;  3L4I A;  2QWP A;  4FSV A;  4UJ0 A;  2B3C A;  5EX5 A;  1KAY A;  3AY9 A;  3C7N B;  1MR4 A;  2E0H A;  2LY5 A;  1C55 A;  5AQZ A;  4FL9 A;  3KC6 A;  3QFP A;  2QWO A;  5AR0 A;  1ICA A;  2YIO A;  2E88 A;  2N2R A;  5AQR A;  4CQK A;  3D2E A;  1POI A;  2GL1 A;  1I6G A;  1NPI A;  3D2F A;  3FZF A;  2YIL A;  1KV0 A;  5F1X A;  1HJO A;  5AQT A;  5AQP A;  3KVG A;  1ATR A;  1NGE A;  1NRA A;  1T7A A;  2YIP A;  2LI7 A;  3LDN A;  1VNB A;  4UAF E;  5AQL A;  5F0X A;  1I2U A;  4AEI A;  1JZA A;  3FZH A;  1KAX A;  1WT7 A;  2KBK A;  3LDQ A;  2B68 A;  4HHF A;  2E8A A;  2QW9 A;  1NE5 A;  1B7D A;  1NRB A;  1SN4 A;  2E2F A;  4AB0 A;  1NGC A;  1ZYV A;  5FPE A;  1T1T A;  2MBK A;  3L56 A;  1K8B A;  3KOX A;  2GMO A;  5BPL A;  1P00 A;  1AHO A;  5AQO A;  1SNB A;  4GNI A;  1ATS A;  3L6Q A;  5AQN A;  1BMR A;  2LKB A;  1NGG A;  2LJ7 A;  3ATU A;  3GKU A;  2KJA A;  1GPS A;  2A7T A;  1QQN A;  1ZVE A;  2LY6 A;  1PTX A;  5AQV A;  5AQM A;  1WMT A;  3A8Y A;  2E3G A;  5AQQ A;  2QWN A;  2MN5 A;  4H5W A;  1P0A A;  1UGL A;  2ATB A;  2SN3 A;  2QWL A;  3KOZ A;  3E7R L;  4HE7 A;  5FPN A;  1LQQ A;  2LN8 A;  1DQ7 A;  1NGJ A;  4HWI A;  4H5N A;  5AQG A;  5AQX A;  1HPM A;  2K35 A;  3IUC A;  1DKG D;  5KK4 A;  1OMY A;  5BPN A;  1JXC A;  3CW4 A;  1QQO A;  2KSK A;  4KBO A;  3QI7 A;  1C56 A;  4V1D C;  2NY9 X;  2ASC A;  1HX1 A;  3E7U X;  5AQF A;  3C7N A;  3FE1 A;  3KOY A;  1MYN A;  3LDP A;  3I33 A;  5EY4 A;  1JZB A;  2QXL A;  1SN1 A;  5AQU A;  1NGA A;  1BA1 A;  5FPM A;  1WWN A;  3QML A;  3R2V A;  1ZUT A;  1VNA A;  3KP1 A;  2M8B B;  3KOW A;  3QFU A;  5BN9 A;  2KYQ A;  5AQW A;  1NGF A;  1YUW A;  3KP0 A;  1AYJ A;  1NH5 A;  2KBH A;  3PSM A;  1BRZ A;  2D56 A;  3FZM A;  1JKZ A;  1OZZ A;  2BRZ A;  1S3X A;  2N69 A;  3KHW A;  2QWR A;  4H5R A;  1NGD A;  5EXW A;  5CY0 A;  1T7E A;  5BN8 A;  5BPM A;  1B3C A;  3GL1 A;  3D2E B;  1BUP A;  1PX9 A;  3D2F B;  2YBR C;  2MZ0 A;  1N4N A;  3M3Z A;  4H5V A;  4H5T A;  2LR3 A;  4UAE F;  1I2V A;  1KAZ A;  2JDQ D;  4IO8 A;  2N2Q A;  1CN2 A;  1QQM A;  2QWQ A;  2QWM A;  5EVZ A;  1ZFU A;  5AQK A;  1SEG A;  5AQH A;  2NY8 X;  2KHO A;  3GDQ A;  1TI5 A;  1T7B A;  3HSC A;  1ZYW A;  2BUP A;  2V7Z A;  5AQS A;  5AQJ A;  1XRS B;  3BK3 C;  3LDL A;  1ZU3 A;  4UAD E;  1GPT A;  1LQH A;  2LT8 A;  2I61 A;  2LJM A;  2KGQ A;  1NGI A;  5FPD A;  1NGH A;  2YEO A;  1LQI A;  2YC1 C;  3SF4 D;  2G2K A;  5F2R A;  2E3F A;  3JXU A;  1I6F A;  1CHZ A;  1ZVG A;  2KBJ A;  2N66 A;  1NGB A;  2KPY A;  1BA0 A;  1L4V A;  3LDO A;  1DJT A;  3FZK A;  3FZL A; 
#chains in the Genus database with same CATH homology
 4AAZ A;  1BK8 A;  1BCG A;  1PE4 A;  1FH3 A;  4KYP A;  1T0Z A;  4UJ0 A;  2B3C A;  1MR4 A;  2E0H A;  2LY5 A;  1C55 A;  1ICA A;  2N2R A;  4CQK A;  2GL1 A;  1I6G A;  1NPI A;  1KV0 A;  1T7A A;  1NRA A;  1DJT A;  2LI7 A;  1VNB A;  4AEI A;  1JZA A;  1I2U A;  1WT7 A;  4HHF A;  2KBK A;  2B68 A;  1NE5 A;  1B7D A;  1NRB A;  1SN4 A;  4AB0 A;  1ZYV A;  1T1T A;  1P00 A;  1AHO A;  1SNB A;  1BMR A;  2LKB A;  2LJ7 A;  2KJA A;  1GPS A;  2A7T A;  1ZVE A;  2LY6 A;  1PTX A;  1WMT A;  1P0A A;  2ATB A;  2SN3 A;  3E7R L;  4HE7 A;  1LQQ A;  1DQ7 A;  5KK4 A;  1OMY A;  1JXC A;  2KSK A;  1C56 A;  4V1D C;  2NY9 X;  2ASC A;  3E7U X;  1MYN A;  1JZB A;  1SN1 A;  1WWN A;  1ZUT A;  1VNA A;  2M8B B;  2KYQ A;  1AYJ A;  1NH5 A;  2KBH A;  3PSM A;  1BRZ A;  1JKZ A;  1OZZ A;  2BRZ A;  2N69 A;  5CY0 A;  1T7E A;  1B3C A;  1PX9 A;  2YBR C;  2MZ0 A;  1N4N A;  1I2V A;  2LR3 A;  2N2Q A;  1CN2 A;  1ZFU A;  1SEG A;  2NY8 X;  1TI5 A;  1T7B A;  1ZYW A;  1GPT A;  1ZU3 A;  1LQH A;  2LT8 A;  2I61 A;  2LJM A;  2KGQ A;  2YEO A;  1LQI A;  2YC1 C;  2E3F A;  1I6F A;  1CHZ A;  1ZVG A;  2KBJ A;  2N66 A;  2KPY A;  1L4V A;  2E3G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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