1SEGA

Crystal structure of a toxin chimera between lqh-alpha-it from the scorpion leiurus quinquestriatus hebraeus and aah2 from androctonus australis hector
Total Genus 17
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
17
sequence length
64
structure length
64
Chain Sequence
VKDGYIVKNYNCTYFCFRNAYCNEECTKLKGESGYCQWASPYGNACYCYKLPDHVPIRVPGKCH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular basis of the high insecticidal potency of scorpion alpha-toxins.
pubmed doi rcsb
molecule tags Toxin
source organism Androctonus australis hector
molecule keywords AAH2: LQH-ALPHA-IT (FACE) CHIMERIC TOXIN
total genus 17
structure length 64
sequence length 64
ec nomenclature
pdb deposition date 2004-02-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00537 Toxin_3 Scorpion toxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.30.10 Alpha Beta 2-Layer Sandwich Defensin A-like Knottin, scorpion toxin-like 1segA00
2KBHA 1I2UA 1PX9A 2YC1C 1AYJA 1LQIA 1OZZA 2M8BB 1WWNA 1ZYVA 2N2QA 2LR3A 2LY6A 2KYQA 1T7AA 1T7EA 2KPYA 2LKBA 2E0HA 1GPTA 1L4VA 2LI7A 2E3GA 3E7RL 1LQHA 2KBKA 1SEGA 1NRAA 1BK8A 1ZUTA 2E3FA 2B68A 2NY9X 2GL1A 1ZVGA 1SN4A 2B3CA 2N2RA 2LY5A 1C55A 1AHOA 4HE7A 2KGQA 1B7DA 4CQKA 1JKZA 5KK4A 2KJAA 2KSKA 1I6GA 1DJTA 1ZVEA 2LJ7A 3E7UX 4UJ0A 1BCGA 3PSMA 5CY0A 2LT8A 1B3CA 1CN2A 1FH3A 1ICAA 1ZYWA 1SNBA 1JZBA 1VNAA 1KV0A 1T7BA 1P00A 1SN1A 2YBRC 1BRZA 1MYNA 1CHZA 1VNBA 4HHFA 2KBJA 2I61A 2BRZA 1NRBA 1PE4A 1NE5A 1T1TA 1NPIA 1NH5A 1C56A 1N4NA 1ZU3A 1WMTA 1GPSA 2SN3A 1LQQA 2MZ0A 1PTXA 1ZFUA 2YEOA 1I2VA 1T0ZA 4AB0A 2LJMA 2A7TA 4KYPA 1OMYA 1JXCA 1WT7A 1DQ7A 1P0AA 1I6FA 2N66A 1TI5A 2N69A 1BMRA 2ASCA 4AEIA 4V1DC 4AAZA 1MR4A 2NY8X 2ATBA 1JZAA
chains in the Genus database with same CATH superfamily
2KBHA 1I2UA 1PX9A 2YC1C 3KOZA 5AQIA 3KVGA 5EY4A 5F1XA 1LQIA 1OZZA 2M8BB 3FE1A 1AYJA 2V7ZA 3KOYA 1WWNA 1ZYVA 2N2QA 2LR3A 2LY6A 2KYQA 1T7AA 1T7EA 2KPYA 2LKBA 2E0HA 3D2FA 4H5VA 5F0XA 1GPTA 2LI7A 1L4VA 4UADE 2E3GA 3E7RL 5AQPA 3D2EB 1LQHA 1BA0A 1HX1A 5FPEA 2KBKA 1KAYA 5AQFA 1NGIA 1SEGA 1S3XA 1ATRA 3FZMA 1NRAA 1BK8A 1ZUTA 3FZLA 2E3FA 4IO8A 1NGGA 1QQNA 4H5TA 2B68A 5EXWA 5BPNA 2NY9X 3BK3C 5AQUA 2YIOA 1NGCA 1POIA 2JDQD 2GL1A 1ZVGA 1SN4A 2B3CA 5F2RA 2N2RA 1NGBA 2LY5A 1NGDA 1C55A 1AHOA 2QXLA 3CW4A 4HE7A 5AQMA 1QQOA 1HPMA 2QW9A 3LDLA 3QFUA 2KGQA 3QFPA 1KAXA 5AQNA 3KHWA 4GNIA 1B7DA 4CQKA 3CQXA 1JKZA 3C7NA 3LDOA 3IUCA 5KK4A 5FPMA 2KJAA 2KSKA 5AQQA 1I6GA 3KOXA 3HSCA 5AQYA 1DJTA 4FL9A 1ZVEA 3KOWA 2LJ7A 3E7UX 4UJ0A 1BCGA 3PSMA 1BA1A 5AR0A 3QI7A 5AQZA 2QWOA 1QQMA 2LT8A 3SF4D 5CY0A 1B3CA 4UAEF 2VY6A 1CN2A 1FH3A 3FZHA 1ICAA 3I33A 1ZYWA 2BUPA 2GMOA 2K35A 2QWQA 5AQXA 1SNBA 3ATUA 5AQRA 1JZBA 3LDPA 5BN9A 5AQGA 2MBKA 1VNAA 2QWPA 5AQLA 1KV0A 1T7BA 2QWLA 2YILA 1P00A 1DKGD 1BUPA 1SN1A 2YBRC 1MYNA 1BRZA 2LN8A 3D2EA 1HJOA 1CHZA 3KP0A 1VNBA 3L56A 1NGFA 3FZFA 2QWMA 4HHFA 2E88A 2KBJA 2I61A 4KBOA 3KC6A 2BRZA 1NRBA 1PE4A 4HWIA 1NE5A 1T1TA 5AQWA 1NPIA 3D2FB 1NH5A 4H5RA 1C56A 3GL1A 5BPMA 3LDNA 1N4NA 2QWRA 4H5NA 1ZU3A 1WMTA 5AQHA 5AQKA 1GPSA 5BN8A 2SN3A 1LQQA 2MZ0A 2YIPA 5AQTA 1PTXA 2MN5A 1ZFUA 1KAZA 2G2KA 2YEOA 3A8YA 3FZKA 3L6QA 4FSVA 5EX5A 5FPDA 3AY9A 5AQJA 1I2VA 1K8BA 1T0ZA 4AB0A 2LJMA 2E2FA 2E8AA 1YUWA 2A7TA 3ATVA 3L4IA 4KYPA 5FPNA 1OMYA 3KP1A 1JXCA 1NGEA 1XRSB 3JXUA 3LDQA 4H5WA 4UAFE 1WT7A 1UGLA 1NGHA 5EVZA 1DQ7A 1P0AA 1I6FA 3GKUA 2QWNA 5AQVA 3C7NB 3GDQA 2N66A 1TI5A 2N69A 1BMRA 2ASCA 1ATSA 4AEIA 5AQSA 3M3ZA 4V1DC 4AAZA 1MR4A 2KHOA 2D56A 2NY8X 5AQOA 3QMLA 3R2VA 1NGJA 5BPLA 2ATBA 1NGAA 1JZAA
chains in the Genus database with same CATH topology
2KBHA 1I2UA 1PX9A 2YC1C 1AYJA 1LQIA 1OZZA 2M8BB 1WWNA 1ZYVA 2N2QA 2LR3A 2LY6A 2KYQA 1T7AA 1T7EA 2KPYA 2LKBA 2E0HA 1GPTA 1L4VA 2LI7A 2E3GA 3E7RL 1LQHA 2KBKA 1SEGA 1NRAA 1BK8A 1ZUTA 2E3FA 2B68A 2NY9X 2GL1A 1ZVGA 1SN4A 2B3CA 2N2RA 2LY5A 1C55A 1AHOA 4HE7A 2KGQA 1B7DA 4CQKA 1JKZA 5KK4A 2KJAA 2KSKA 1I6GA 1DJTA 1ZVEA 2LJ7A 3E7UX 4UJ0A 1BCGA 3PSMA 5CY0A 2LT8A 1B3CA 1CN2A 1FH3A 1ICAA 1ZYWA 1SNBA 1JZBA 1VNAA 1KV0A 1T7BA 1P00A 1SN1A 2YBRC 1BRZA 1MYNA 1CHZA 1VNBA 4HHFA 2KBJA 2I61A 2BRZA 1NRBA 1PE4A 1NE5A 1T1TA 1NPIA 1NH5A 1C56A 1N4NA 1ZU3A 1WMTA 1GPSA 2SN3A 1LQQA 2MZ0A 1PTXA 1ZFUA 2YEOA 1I2VA 1T0ZA 4AB0A 2LJMA 2A7TA 4KYPA 1OMYA 1JXCA 1WT7A 1DQ7A 1P0AA 1I6FA 2N66A 1TI5A 2N69A 1BMRA 2ASCA 4AEIA 4V1DC 4AAZA 1MR4A 2NY8X 2ATBA 1JZAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KBH A;  1I2U A;  1PX9 A;  2YC1 C;  1AYJ A;  1LQI A;  1OZZ A;  2M8B B;  1WWN A;  1ZYV A;  2N2Q A;  2LR3 A;  2LY6 A;  2KYQ A;  1T7A A;  1T7E A;  2KPY A;  2LKB A;  2E0H A;  1GPT A;  1L4V A;  2LI7 A;  2E3G A;  3E7R L;  1LQH A;  2KBK A;  1SEG A;  1NRA A;  1BK8 A;  1ZUT A;  2E3F A;  2B68 A;  2NY9 X;  2GL1 A;  1ZVG A;  1SN4 A;  2B3C A;  2N2R A;  2LY5 A;  1C55 A;  1AHO A;  4HE7 A;  2KGQ A;  1B7D A;  4CQK A;  1JKZ A;  5KK4 A;  2KJA A;  2KSK A;  1I6G A;  1DJT A;  1ZVE A;  2LJ7 A;  3E7U X;  4UJ0 A;  1BCG A;  3PSM A;  5CY0 A;  2LT8 A;  1B3C A;  1CN2 A;  1FH3 A;  1ICA A;  1ZYW A;  1SNB A;  1JZB A;  1VNA A;  1KV0 A;  1T7B A;  1P00 A;  1SN1 A;  2YBR C;  1BRZ A;  1MYN A;  1CHZ A;  1VNB A;  4HHF A;  2KBJ A;  2I61 A;  2BRZ A;  1NRB A;  1PE4 A;  1NE5 A;  1T1T A;  1NPI A;  1NH5 A;  1C56 A;  1N4N A;  1ZU3 A;  1WMT A;  1GPS A;  2SN3 A;  1LQQ A;  2MZ0 A;  1PTX A;  1ZFU A;  2YEO A;  1I2V A;  1T0Z A;  4AB0 A;  2LJM A;  2A7T A;  4KYP A;  1OMY A;  1JXC A;  1WT7 A;  1DQ7 A;  1P0A A;  1I6F A;  2N66 A;  1TI5 A;  2N69 A;  1BMR A;  2ASC A;  4AEI A;  4V1D C;  4AAZ A;  1MR4 A;  2NY8 X;  2ATB A;  1JZA A; 
#chains in the Genus database with same CATH topology
 2KBH A;  1I2U A;  1PX9 A;  2YC1 C;  3KOZ A;  5AQI A;  3KVG A;  5EY4 A;  5F1X A;  1LQI A;  1OZZ A;  2M8B B;  3FE1 A;  1AYJ A;  2V7Z A;  3KOY A;  1WWN A;  1ZYV A;  2N2Q A;  2LR3 A;  2LY6 A;  2KYQ A;  1T7A A;  1T7E A;  2KPY A;  2LKB A;  2E0H A;  3D2F A;  4H5V A;  5F0X A;  1GPT A;  2LI7 A;  1L4V A;  4UAD E;  2E3G A;  3E7R L;  5AQP A;  3D2E B;  1LQH A;  1BA0 A;  1HX1 A;  5FPE A;  2KBK A;  1KAY A;  5AQF A;  1NGI A;  1SEG A;  1S3X A;  1ATR A;  3FZM A;  1NRA A;  1BK8 A;  1ZUT A;  3FZL A;  2E3F A;  4IO8 A;  1NGG A;  1QQN A;  4H5T A;  2B68 A;  5EXW A;  5BPN A;  2NY9 X;  3BK3 C;  5AQU A;  2YIO A;  1NGC A;  1POI A;  2JDQ D;  2GL1 A;  1ZVG A;  1SN4 A;  2B3C A;  5F2R A;  2N2R A;  1NGB A;  2LY5 A;  1NGD A;  1C55 A;  1AHO A;  2QXL A;  3CW4 A;  4HE7 A;  5AQM A;  1QQO A;  1HPM A;  2QW9 A;  3LDL A;  3QFU A;  2KGQ A;  3QFP A;  1KAX A;  5AQN A;  3KHW A;  4GNI A;  1B7D A;  4CQK A;  3CQX A;  1JKZ A;  3C7N A;  3LDO A;  3IUC A;  5KK4 A;  5FPM A;  2KJA A;  2KSK A;  5AQQ A;  1I6G A;  3KOX A;  3HSC A;  5AQY A;  1DJT A;  4FL9 A;  1ZVE A;  3KOW A;  2LJ7 A;  3E7U X;  4UJ0 A;  1BCG A;  3PSM A;  1BA1 A;  5AR0 A;  3QI7 A;  5AQZ A;  2QWO A;  1QQM A;  2LT8 A;  3SF4 D;  5CY0 A;  1B3C A;  4UAE F;  2VY6 A;  1CN2 A;  1FH3 A;  3FZH A;  1ICA A;  3I33 A;  1ZYW A;  2BUP A;  2GMO A;  2K35 A;  2QWQ A;  5AQX A;  1SNB A;  3ATU A;  5AQR A;  1JZB A;  3LDP A;  5BN9 A;  5AQG A;  2MBK A;  1VNA A;  2QWP A;  5AQL A;  1KV0 A;  1T7B A;  2QWL A;  2YIL A;  1P00 A;  1DKG D;  1BUP A;  1SN1 A;  2YBR C;  1MYN A;  1BRZ A;  2LN8 A;  3D2E A;  1HJO A;  1CHZ A;  3KP0 A;  1VNB A;  3L56 A;  1NGF A;  3FZF A;  2QWM A;  4HHF A;  2E88 A;  2KBJ A;  2I61 A;  4KBO A;  3KC6 A;  2BRZ A;  1NRB A;  1PE4 A;  4HWI A;  1NE5 A;  1T1T A;  5AQW A;  1NPI A;  3D2F B;  1NH5 A;  4H5R A;  1C56 A;  3GL1 A;  5BPM A;  3LDN A;  1N4N A;  2QWR A;  4H5N A;  1ZU3 A;  1WMT A;  5AQH A;  5AQK A;  1GPS A;  5BN8 A;  2SN3 A;  1LQQ A;  2MZ0 A;  2YIP A;  5AQT A;  1PTX A;  2MN5 A;  1ZFU A;  1KAZ A;  2G2K A;  2YEO A;  3A8Y A;  3FZK A;  3L6Q A;  4FSV A;  5EX5 A;  5FPD A;  3AY9 A;  5AQJ A;  1I2V A;  1K8B A;  1T0Z A;  4AB0 A;  2LJM A;  2E2F A;  2E8A A;  1YUW A;  2A7T A;  3ATV A;  3L4I A;  4KYP A;  5FPN A;  1OMY A;  3KP1 A;  1JXC A;  1NGE A;  1XRS B;  3JXU A;  3LDQ A;  4H5W A;  4UAF E;  1WT7 A;  1UGL A;  1NGH A;  5EVZ A;  1DQ7 A;  1P0A A;  1I6F A;  3GKU A;  2QWN A;  5AQV A;  3C7N B;  3GDQ A;  2N66 A;  1TI5 A;  2N69 A;  1BMR A;  2ASC A;  1ATS A;  4AEI A;  5AQS A;  3M3Z A;  4V1D C;  4AAZ A;  1MR4 A;  2KHO A;  2D56 A;  2NY8 X;  5AQO A;  3QML A;  3R2V A;  1NGJ A;  5BPL A;  2ATB A;  1NGA A;  1JZA A; 
#chains in the Genus database with same CATH homology
 2KBH A;  1I2U A;  1PX9 A;  2YC1 C;  1AYJ A;  1LQI A;  1OZZ A;  2M8B B;  1WWN A;  1ZYV A;  2N2Q A;  2LR3 A;  2LY6 A;  2KYQ A;  1T7A A;  1T7E A;  2KPY A;  2LKB A;  2E0H A;  1GPT A;  1L4V A;  2LI7 A;  2E3G A;  3E7R L;  1LQH A;  2KBK A;  1SEG A;  1NRA A;  1BK8 A;  1ZUT A;  2E3F A;  2B68 A;  2NY9 X;  2GL1 A;  1ZVG A;  1SN4 A;  2B3C A;  2N2R A;  2LY5 A;  1C55 A;  1AHO A;  4HE7 A;  2KGQ A;  1B7D A;  4CQK A;  1JKZ A;  5KK4 A;  2KJA A;  2KSK A;  1I6G A;  1DJT A;  1ZVE A;  2LJ7 A;  3E7U X;  4UJ0 A;  1BCG A;  3PSM A;  5CY0 A;  2LT8 A;  1B3C A;  1CN2 A;  1FH3 A;  1ICA A;  1ZYW A;  1SNB A;  1JZB A;  1VNA A;  1KV0 A;  1T7B A;  1P00 A;  1SN1 A;  2YBR C;  1BRZ A;  1MYN A;  1CHZ A;  1VNB A;  4HHF A;  2KBJ A;  2I61 A;  2BRZ A;  1NRB A;  1PE4 A;  1NE5 A;  1T1T A;  1NPI A;  1NH5 A;  1C56 A;  1N4N A;  1ZU3 A;  1WMT A;  1GPS A;  2SN3 A;  1LQQ A;  2MZ0 A;  1PTX A;  1ZFU A;  2YEO A;  1I2V A;  1T0Z A;  4AB0 A;  2LJM A;  2A7T A;  4KYP A;  1OMY A;  1JXC A;  1WT7 A;  1DQ7 A;  1P0A A;  1I6F A;  2N66 A;  1TI5 A;  2N69 A;  1BMR A;  2ASC A;  4AEI A;  4V1D C;  4AAZ A;  1MR4 A;  2NY8 X;  2ATB A;  1JZA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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