2A7TA

Crystal structure of a novel neurotoxin from buthus tamalus at 2.2a resolution.
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
64
structure length
64
Chain Sequence
GEDGYIADGDNCTYICTFNNYCHALCTDKKGDSGACDWWVPYGVVCWCEDLPTPVPIRGSGKCR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Toxin
publication title Crystal structure of a highly acidic neurotoxin from scorpion Buthus tamulus at 2.2A resolution reveals novel structural features.
pubmed doi rcsb
molecule keywords Neurotoxin
total genus 14
structure length 64
sequence length 64
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-07-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00537 Toxin_3 Scorpion toxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.30.10 Alpha Beta 2-Layer Sandwich Defensin A-like Knottin, scorpion toxin-like 2a7tA00
1JKZA 1LQIA 1ZVGA 1ZUTA 1P0AA 2E3GA 2NY9X 2NY8X 1NRAA 1OZZA 2N2RA 1GPSA 1WMTA 1ZYWA 1ZU3A 2LT8A 1ICAA 1B3CA 1BMRA 1DQ7A 3E7UX 1PE4A 2LR3A 1KV0A 2E0HA 4AAZA 1MR4A 2ASCA 4V1DC 1N4NA 1BRZA 2YBRC 1I2UA 1ZFUA 2LJ7A 2M8BB 1SEGA 1DJTA 1NPIA 1T7EA 2YEOA 3PSMA 1LQHA 1FH3A 2LKBA 1BK8A 2N69A 1T0ZA 2KBHA 1B7DA 2ATBA 2LI7A 1C56A 4AEIA 2B3CA 1JZBA 2LY6A 4CQKA 1TI5A 1SNBA 1CN2A 2I61A 2YC1C 2B68A 2KJAA 1T7BA 5CY0A 1OMYA 1ZVEA 1NE5A 5KK4A 2KBJA 1T7AA 1WT7A 2N2QA 1AYJA 2KYQA 1JZAA 4UJ0A 3E7RL 1I6GA 1MYNA 1BCGA 1VNBA 1WWNA 1NRBA 1VNAA 1AHOA 4HE7A 1ZYVA 1I2VA 1SN1A 1PTXA 1C55A 1I6FA 2SN3A 2MZ0A 2KBKA 4HHFA 1LQQA 1SN4A 4AB0A 1GPTA 2KPYA 2BRZA 2E3FA 1CHZA 2LY5A 1L4VA 1NH5A 1P00A 2KSKA 1T1TA 2A7TA 4KYPA 1PX9A 2KGQA 1JXCA 2GL1A 2N66A 2LJMA
chains in the Genus database with same CATH superfamily
1KAZA 1JKZA 1LQIA 5AQVA 1ZVGA 1ZUTA 3ATUA 5AQIA 1P0AA 3QI7A 4GNIA 5AQFA 5EY4A 2E3GA 2GMOA 3BK3C 4UAFE 2NY9X 2LN8A 1NGHA 2NY8X 1NRAA 3FZLA 3I33A 1OZZA 2N2RA 5AQOA 1GPSA 2YIPA 3M3ZA 1WMTA 1ZYWA 1ZU3A 2LT8A 5EVZA 1ICAA 1B3CA 3D2EB 1BMRA 3KVGA 3D2FB 3LDQA 1DQ7A 3E7UX 1K8BA 1NGCA 2K35A 5AQKA 1PE4A 2LR3A 3L6QA 5AQSA 5AQLA 3LDLA 4H5RA 3IUCA 1KV0A 3GDQA 5AQNA 3L4IA 2E0HA 4AAZA 3KHWA 1MR4A 3KOZA 3AY9A 3FZHA 2ASCA 1ATRA 4V1DC 2MBKA 5AQHA 2E88A 2QWRA 5FPNA 1N4NA 4H5VA 5AQGA 1BRZA 2QXLA 2YBRC 3LDNA 1I2UA 1ZFUA 5BN9A 2LJ7A 2M8BB 2QWLA 3CQXA 5AR0A 1SEGA 5EXWA 3QFPA 1DJTA 3ATVA 1NPIA 1QQNA 5AQZA 1BA0A 1T7EA 2YEOA 3PSMA 1LQHA 4FSVA 3D2FA 1FH3A 2LKBA 3FZKA 4HWIA 1BK8A 2N69A 1T0ZA 2VY6A 3C7NB 5F1XA 5AQUA 2KBHA 1HJOA 2E8AA 4H5WA 5FPEA 1B7DA 1NGBA 2ATBA 2LI7A 1C56A 4AEIA 2QWMA 1NGIA 5F2RA 3SF4D 1JZBA 2B3CA 2LY6A 5FPMA 1DKGD 4CQKA 5F0XA 1TI5A 1SNBA 1NGEA 2I61A 1CN2A 3A8YA 3KOWA 3R2VA 2YC1C 1ATSA 2B68A 2KJAA 1T7BA 5CY0A 1OMYA 3KOXA 1ZVEA 1NE5A 3FZMA 3FE1A 4UAEF 2V7ZA 2KHOA 5KK4A 2KBJA 1T7AA 1QQOA 3JXUA 3QFUA 2JDQD 1WT7A 2N2QA 3KC6A 1AYJA 4UADE 5AQPA 1NGGA 2KYQA 5EX5A 1JZAA 4IO8A 4UJ0A 3E7RL 3HSCA 1I6GA 1KAXA 3D2EA 1MYNA 1BCGA 1VNBA 3LDPA 1KAYA 5FPDA 1S3XA 1WWNA 2D56A 1NRBA 1VNAA 3GL1A 3L56A 1AHOA 4H5TA 4HE7A 1ZYVA 5BPNA 1SN1A 1PTXA 1C55A 1I2VA 5AQRA 1I6FA 2YILA 1NGDA 2SN3A 2MZ0A 2KBKA 3QMLA 3GKUA 4HHFA 5BPLA 1LQQA 1SN4A 4AB0A 1GPTA 1HX1A 5BN8A 1HPMA 4KBOA 5AQWA 1NGFA 2G2KA 2KPYA 2QWNA 4FL9A 2BRZA 2E3FA 1CHZA 1BUPA 2LY5A 2YIOA 3LDOA 1L4VA 1UGLA 1NH5A 3CW4A 1BA1A 1P00A 2QWOA 1NGAA 5AQYA 2KSKA 1T1TA 2A7TA 4KYPA 3KOYA 5AQQA 3KP1A 2QWQA 3C7NA 2E2FA 1QQMA 4H5NA 1PX9A 1NGJA 1POIA 2KGQA 1JXCA 2GL1A 5AQTA 3FZFA 2QWPA 2MN5A 5AQXA 1XRSB 2N66A 2QW9A 2LJMA 2BUPA 3KP0A 5AQJA 5AQMA 5BPMA 1YUWA
chains in the Genus database with same CATH topology
1JKZA 1LQIA 1ZVGA 1ZUTA 1P0AA 2E3GA 2NY9X 2NY8X 1NRAA 1OZZA 2N2RA 1GPSA 1WMTA 1ZYWA 1ZU3A 2LT8A 1ICAA 1B3CA 1BMRA 1DQ7A 3E7UX 1PE4A 2LR3A 1KV0A 2E0HA 4AAZA 1MR4A 2ASCA 4V1DC 1N4NA 1BRZA 2YBRC 1I2UA 1ZFUA 2LJ7A 2M8BB 1SEGA 1DJTA 1NPIA 1T7EA 2YEOA 3PSMA 1LQHA 1FH3A 2LKBA 1BK8A 2N69A 1T0ZA 2KBHA 1B7DA 2ATBA 2LI7A 1C56A 4AEIA 2B3CA 1JZBA 2LY6A 4CQKA 1TI5A 1SNBA 1CN2A 2I61A 2YC1C 2B68A 2KJAA 1T7BA 5CY0A 1OMYA 1ZVEA 1NE5A 5KK4A 2KBJA 1T7AA 1WT7A 2N2QA 1AYJA 2KYQA 1JZAA 4UJ0A 3E7RL 1I6GA 1MYNA 1BCGA 1VNBA 1WWNA 1NRBA 1VNAA 1AHOA 4HE7A 1ZYVA 1I2VA 1SN1A 1PTXA 1C55A 1I6FA 2SN3A 2MZ0A 2KBKA 4HHFA 1LQQA 1SN4A 4AB0A 1GPTA 2KPYA 2BRZA 2E3FA 1CHZA 2LY5A 1L4VA 1NH5A 1P00A 2KSKA 1T1TA 2A7TA 4KYPA 1PX9A 2KGQA 1JXCA 2GL1A 2N66A 2LJMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JKZ A;  1LQI A;  1ZVG A;  1ZUT A;  1P0A A;  2E3G A;  2NY9 X;  2NY8 X;  1NRA A;  1OZZ A;  2N2R A;  1GPS A;  1WMT A;  1ZYW A;  1ZU3 A;  2LT8 A;  1ICA A;  1B3C A;  1BMR A;  1DQ7 A;  3E7U X;  1PE4 A;  2LR3 A;  1KV0 A;  2E0H A;  4AAZ A;  1MR4 A;  2ASC A;  4V1D C;  1N4N A;  1BRZ A;  2YBR C;  1I2U A;  1ZFU A;  2LJ7 A;  2M8B B;  1SEG A;  1DJT A;  1NPI A;  1T7E A;  2YEO A;  3PSM A;  1LQH A;  1FH3 A;  2LKB A;  1BK8 A;  2N69 A;  1T0Z A;  2KBH A;  1B7D A;  2ATB A;  2LI7 A;  1C56 A;  4AEI A;  2B3C A;  1JZB A;  2LY6 A;  4CQK A;  1TI5 A;  1SNB A;  1CN2 A;  2I61 A;  2YC1 C;  2B68 A;  2KJA A;  1T7B A;  5CY0 A;  1OMY A;  1ZVE A;  1NE5 A;  5KK4 A;  2KBJ A;  1T7A A;  1WT7 A;  2N2Q A;  1AYJ A;  2KYQ A;  1JZA A;  4UJ0 A;  3E7R L;  1I6G A;  1MYN A;  1BCG A;  1VNB A;  1WWN A;  1NRB A;  1VNA A;  1AHO A;  4HE7 A;  1ZYV A;  1I2V A;  1SN1 A;  1PTX A;  1C55 A;  1I6F A;  2SN3 A;  2MZ0 A;  2KBK A;  4HHF A;  1LQQ A;  1SN4 A;  4AB0 A;  1GPT A;  2KPY A;  2BRZ A;  2E3F A;  1CHZ A;  2LY5 A;  1L4V A;  1NH5 A;  1P00 A;  2KSK A;  1T1T A;  2A7T A;  4KYP A;  1PX9 A;  2KGQ A;  1JXC A;  2GL1 A;  2N66 A;  2LJM A; 
#chains in the Genus database with same CATH topology
 1KAZ A;  1JKZ A;  1LQI A;  5AQV A;  1ZVG A;  1ZUT A;  3ATU A;  5AQI A;  1P0A A;  3QI7 A;  4GNI A;  5AQF A;  5EY4 A;  2E3G A;  2GMO A;  3BK3 C;  4UAF E;  2NY9 X;  2LN8 A;  1NGH A;  2NY8 X;  1NRA A;  3FZL A;  3I33 A;  1OZZ A;  2N2R A;  5AQO A;  1GPS A;  2YIP A;  3M3Z A;  1WMT A;  1ZYW A;  1ZU3 A;  2LT8 A;  5EVZ A;  1ICA A;  1B3C A;  3D2E B;  1BMR A;  3KVG A;  3D2F B;  3LDQ A;  1DQ7 A;  3E7U X;  1K8B A;  1NGC A;  2K35 A;  5AQK A;  1PE4 A;  2LR3 A;  3L6Q A;  5AQS A;  5AQL A;  3LDL A;  4H5R A;  3IUC A;  1KV0 A;  3GDQ A;  5AQN A;  3L4I A;  2E0H A;  4AAZ A;  3KHW A;  1MR4 A;  3KOZ A;  3AY9 A;  3FZH A;  2ASC A;  1ATR A;  4V1D C;  2MBK A;  5AQH A;  2E88 A;  2QWR A;  5FPN A;  1N4N A;  4H5V A;  5AQG A;  1BRZ A;  2QXL A;  2YBR C;  3LDN A;  1I2U A;  1ZFU A;  5BN9 A;  2LJ7 A;  2M8B B;  2QWL A;  3CQX A;  5AR0 A;  1SEG A;  5EXW A;  3QFP A;  1DJT A;  3ATV A;  1NPI A;  1QQN A;  5AQZ A;  1BA0 A;  1T7E A;  2YEO A;  3PSM A;  1LQH A;  4FSV A;  3D2F A;  1FH3 A;  2LKB A;  3FZK A;  4HWI A;  1BK8 A;  2N69 A;  1T0Z A;  2VY6 A;  3C7N B;  5F1X A;  5AQU A;  2KBH A;  1HJO A;  2E8A A;  4H5W A;  5FPE A;  1B7D A;  1NGB A;  2ATB A;  2LI7 A;  1C56 A;  4AEI A;  2QWM A;  1NGI A;  5F2R A;  3SF4 D;  1JZB A;  2B3C A;  2LY6 A;  5FPM A;  1DKG D;  4CQK A;  5F0X A;  1TI5 A;  1SNB A;  1NGE A;  2I61 A;  1CN2 A;  3A8Y A;  3KOW A;  3R2V A;  2YC1 C;  1ATS A;  2B68 A;  2KJA A;  1T7B A;  5CY0 A;  1OMY A;  3KOX A;  1ZVE A;  1NE5 A;  3FZM A;  3FE1 A;  4UAE F;  2V7Z A;  2KHO A;  5KK4 A;  2KBJ A;  1T7A A;  1QQO A;  3JXU A;  3QFU A;  2JDQ D;  1WT7 A;  2N2Q A;  3KC6 A;  1AYJ A;  4UAD E;  5AQP A;  1NGG A;  2KYQ A;  5EX5 A;  1JZA A;  4IO8 A;  4UJ0 A;  3E7R L;  3HSC A;  1I6G A;  1KAX A;  3D2E A;  1MYN A;  1BCG A;  1VNB A;  3LDP A;  1KAY A;  5FPD A;  1S3X A;  1WWN A;  2D56 A;  1NRB A;  1VNA A;  3GL1 A;  3L56 A;  1AHO A;  4H5T A;  4HE7 A;  1ZYV A;  5BPN A;  1SN1 A;  1PTX A;  1C55 A;  1I2V A;  5AQR A;  1I6F A;  2YIL A;  1NGD A;  2SN3 A;  2MZ0 A;  2KBK A;  3QML A;  3GKU A;  4HHF A;  5BPL A;  1LQQ A;  1SN4 A;  4AB0 A;  1GPT A;  1HX1 A;  5BN8 A;  1HPM A;  4KBO A;  5AQW A;  1NGF A;  2G2K A;  2KPY A;  2QWN A;  4FL9 A;  2BRZ A;  2E3F A;  1CHZ A;  1BUP A;  2LY5 A;  2YIO A;  3LDO A;  1L4V A;  1UGL A;  1NH5 A;  3CW4 A;  1BA1 A;  1P00 A;  2QWO A;  1NGA A;  5AQY A;  2KSK A;  1T1T A;  2A7T A;  4KYP A;  3KOY A;  5AQQ A;  3KP1 A;  2QWQ A;  3C7N A;  2E2F A;  1QQM A;  4H5N A;  1PX9 A;  1NGJ A;  1POI A;  2KGQ A;  1JXC A;  2GL1 A;  5AQT A;  3FZF A;  2QWP A;  2MN5 A;  5AQX A;  1XRS B;  2N66 A;  2QW9 A;  2LJM A;  2BUP A;  3KP0 A;  5AQJ A;  5AQM A;  5BPM A;  1YUW A; 
#chains in the Genus database with same CATH homology
 1JKZ A;  1LQI A;  1ZVG A;  1ZUT A;  1P0A A;  2E3G A;  2NY9 X;  2NY8 X;  1NRA A;  1OZZ A;  2N2R A;  1GPS A;  1WMT A;  1ZYW A;  1ZU3 A;  2LT8 A;  1ICA A;  1B3C A;  1BMR A;  1DQ7 A;  3E7U X;  1PE4 A;  2LR3 A;  1KV0 A;  2E0H A;  4AAZ A;  1MR4 A;  2ASC A;  4V1D C;  1N4N A;  1BRZ A;  2YBR C;  1I2U A;  1ZFU A;  2LJ7 A;  2M8B B;  1SEG A;  1DJT A;  1NPI A;  1T7E A;  2YEO A;  3PSM A;  1LQH A;  1FH3 A;  2LKB A;  1BK8 A;  2N69 A;  1T0Z A;  2KBH A;  1B7D A;  2ATB A;  2LI7 A;  1C56 A;  4AEI A;  2B3C A;  1JZB A;  2LY6 A;  4CQK A;  1TI5 A;  1SNB A;  1CN2 A;  2I61 A;  2YC1 C;  2B68 A;  2KJA A;  1T7B A;  5CY0 A;  1OMY A;  1ZVE A;  1NE5 A;  5KK4 A;  2KBJ A;  1T7A A;  1WT7 A;  2N2Q A;  1AYJ A;  2KYQ A;  1JZA A;  4UJ0 A;  3E7R L;  1I6G A;  1MYN A;  1BCG A;  1VNB A;  1WWN A;  1NRB A;  1VNA A;  1AHO A;  4HE7 A;  1ZYV A;  1I2V A;  1SN1 A;  1PTX A;  1C55 A;  1I6F A;  2SN3 A;  2MZ0 A;  2KBK A;  4HHF A;  1LQQ A;  1SN4 A;  4AB0 A;  1GPT A;  2KPY A;  2BRZ A;  2E3F A;  1CHZ A;  2LY5 A;  1L4V A;  1NH5 A;  1P00 A;  2KSK A;  1T1T A;  2A7T A;  4KYP A;  1PX9 A;  2KGQ A;  1JXC A;  2GL1 A;  2N66 A;  2LJM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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