2I61A

Depressant anti-insect neurotoxin, lqhit2 from leiurus quinquestriatus hebraeus
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
62
structure length
62
Chain Sequence
MDGYIKRRDGCKVACLIGNEGCDKECKAYGGSYGYCWTWGLACWCEGLPDDKTWKSETNTCG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-ray Structure and Mutagenesis of the Scorpion Depressant Toxin LqhIT2 Reveals Key Determinants Crucial for Activity and Anti-Insect Selectivity.
pubmed doi rcsb
molecule tags Toxin
source organism Leiurus quinquestriatus hebraeus
molecule keywords Insect toxin 2
total genus 15
structure length 62
sequence length 62
ec nomenclature
pdb deposition date 2006-08-27
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.30.10 Alpha Beta 2-Layer Sandwich Defensin A-like Knottin, scorpion toxin-like 2i61A00
2LI7A 1DJTA 1I6GA 2GL1A 1C55A 1B7DA 2KBHA 1BCGA 1NH5A 2YC1C 5KK4A 1GPTA 1T7BA 1WT7A 2KPYA 4V1DC 1SNBA 1T0ZA 2N69A 2B3CA 1DQ7A 2E3GA 1BMRA 1GPSA 1ZYWA 1TI5A 1VNAA 2N66A 4AAZA 1N4NA 1ZFUA 1T1TA 1P0AA 2NY9X 1AYJA 1CHZA 2KSKA 2KYQA 1VNBA 1T7AA 2KGQA 4CQKA 2ASCA 4AEIA 1SEGA 1ZVGA 1BK8A 1PE4A 1OMYA 2A7TA 2MZ0A 1ZUTA 1LQHA 1BRZA 1C56A 1I2UA 1ZYVA 1SN1A 1T7EA 2LY6A 1SN4A 2NY8X 2LJ7A 1B3CA 4AB0A 1WWNA 3E7RL 2LKBA 2YBRC 1NRAA 2LT8A 1LQQA 2I61A 1L4VA 2N2QA 1CN2A 2E0HA 2LR3A 1JKZA 1MYNA 2KBKA 2SN3A 1NRBA 2BRZA 1ZU3A 2B68A 1ICAA 4HHFA 1ZVEA 1MR4A 2ATBA 2N2RA 1JZAA 1NPIA 2KBJA 4HE7A 2M8BB 5CY0A 1AHOA 2YEOA 1JXCA 1I6FA 2LY5A 3E7UX 1NE5A 1PTXA 1KV0A 1P00A 2LJMA 1OZZA 1WMTA 1I2VA 4UJ0A 2E3FA 2KJAA 1PX9A 4KYPA 1FH3A 1JZBA 3PSMA 1LQIA
chains in the Genus database with same CATH superfamily
4H5RA 5AQIA 2LI7A 1DJTA 3D2FA 5FPMA 3A8YA 1I6GA 2GL1A 2MBKA 1C55A 1B7DA 1NGGA 3BK3C 1NGBA 2KBHA 1BCGA 3I33A 5AQSA 1NGAA 1NH5A 2YC1C 4FSVA 3M3ZA 4UAEF 3QMLA 5KK4A 3AY9A 5AQGA 1BUPA 1HPMA 3KOWA 1GPTA 1T7BA 1WT7A 2E8AA 1NGHA 2KPYA 2VY6A 1SNBA 1T0ZA 2N69A 2B3CA 1DQ7A 2E3GA 2YILA 3ATUA 1ZYWA 2QWOA 3C7NB 1TI5A 3KP0A 1BMRA 1DKGD 1GPSA 1HJOA 3KOXA 1VNAA 2N66A 2QWPA 4KBOA 1POIA 2QWMA 3FZHA 3LDOA 4AAZA 4H5TA 5AQZA 5F1XA 2E2FA 2QW9A 3LDPA 1KAXA 1N4NA 1ZFUA 3FZMA 3L56A 1T1TA 3KOYA 1P0AA 1XRSB 2NY9X 1AYJA 5AQRA 1CHZA 2KSKA 2KYQA 3KOZA 1BA0A 1VNBA 1T7AA 2K35A 2KGQA 3KVGA 3LDLA 4CQKA 2ASCA 5BPLA 3L4IA 1QQOA 4AEIA 3D2EA 1SEGA 1ZVGA 1BK8A 1PE4A 1OMYA 2QWLA 1KAYA 2A7TA 2MZ0A 1ZUTA 1LQHA 1YUWA 2QWQA 5AQXA 5EXWA 1NGDA 5AQPA 5AQWA 1C56A 3R2VA 5AQTA 5FPDA 1BRZA 1I2UA 1ZYVA 1SN1A 1T7EA 2LY6A 3LDQA 5BN8A 1SN4A 2NY8X 2LJ7A 1B3CA 3L6QA 1ATRA 5EX5A 2JDQD 1BA1A 4AB0A 1WWNA 3E7RL 4H5NA 2LKBA 2YBRC 4H5VA 1NRAA 2LT8A 3FE1A 3GL1A 1LQQA 4H5WA 2I61A 1NGIA 1L4VA 3KC6A 3SF4D 1NGCA 2N2QA 3KP1A 5BPNA 1CN2A 5AQLA 2E0HA 3JXUA 3D2FB 4FL9A 5EVZA 2LR3A 1JKZA 1HX1A 5BN9A 1MYNA 3KHWA 2KBKA 3QI7A 5AQUA 3D2EB 2SN3A 1NGJA 1QQMA 1NRBA 2QWRA 2BRZA 5AQFA 3C7NA 2E88A 1ZU3A 2B68A 1ICAA 3IUCA 3FZKA 5AQNA 4UADE 4HHFA 5AQVA 1ZVEA 1MR4A 1UGLA 3CW4A 2ATBA 2N2RA 1JZAA 1NPIA 3ATVA 2KBJA 4HE7A 2M8BB 4GNIA 5F0XA 5CY0A 1AHOA 5AQYA 2MN5A 3GDQA 5AQOA 5FPEA 2YEOA 1JXCA 1I6FA 2LY5A 3E7UX 1NE5A 1PTXA 3GKUA 5AQJA 4V1DC 1ATSA 2D56A 2V7ZA 1KV0A 1P00A 2QXLA 3QFPA 5AQMA 2LJMA 5FPNA 5AR0A 1OZZA 2GMOA 2LN8A 3FZFA 5AQHA 1WMTA 1NGEA 3QFUA 4HWIA 1I2VA 3HSCA 2BUPA 4UJ0A 1S3XA 2YIPA 5BPMA 2E3FA 2KJAA 3FZLA 1PX9A 4KYPA 5EY4A 5F2RA 4IO8A 3LDNA 1FH3A 1KAZA 1NGFA 3CQXA 1JZBA 3PSMA 1K8BA 1LQIA 4UAFE 2QWNA 2KHOA 5AQKA 1QQNA 2YIOA 2G2KA 5AQQA
chains in the Genus database with same CATH topology
2LI7A 1DJTA 1I6GA 2GL1A 1C55A 1B7DA 2KBHA 1BCGA 1NH5A 2YC1C 5KK4A 1GPTA 1T7BA 1WT7A 2KPYA 4V1DC 1SNBA 1T0ZA 2N69A 2B3CA 1DQ7A 2E3GA 1BMRA 1GPSA 1ZYWA 1TI5A 1VNAA 2N66A 4AAZA 1N4NA 1ZFUA 1T1TA 1P0AA 2NY9X 1AYJA 1CHZA 2KSKA 2KYQA 1VNBA 1T7AA 2KGQA 4CQKA 2ASCA 4AEIA 1SEGA 1ZVGA 1BK8A 1PE4A 1OMYA 2A7TA 2MZ0A 1ZUTA 1LQHA 1BRZA 1C56A 1I2UA 1ZYVA 1SN1A 1T7EA 2LY6A 1SN4A 2NY8X 2LJ7A 1B3CA 4AB0A 1WWNA 3E7RL 2LKBA 2YBRC 1NRAA 2LT8A 1LQQA 2I61A 1L4VA 2N2QA 1CN2A 2E0HA 2LR3A 1JKZA 1MYNA 2KBKA 2SN3A 1NRBA 2BRZA 1ZU3A 2B68A 1ICAA 4HHFA 1ZVEA 1MR4A 2ATBA 2N2RA 1JZAA 1NPIA 2KBJA 4HE7A 2M8BB 5CY0A 1AHOA 2YEOA 1JXCA 1I6FA 2LY5A 3E7UX 1NE5A 1PTXA 1KV0A 1P00A 2LJMA 1OZZA 1WMTA 1I2VA 4UJ0A 2E3FA 2KJAA 1PX9A 4KYPA 1FH3A 1JZBA 3PSMA 1LQIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2LI7 A;  1DJT A;  1I6G A;  2GL1 A;  1C55 A;  1B7D A;  2KBH A;  1BCG A;  1NH5 A;  2YC1 C;  5KK4 A;  1GPT A;  1T7B A;  1WT7 A;  2KPY A;  4V1D C;  1SNB A;  1T0Z A;  2N69 A;  2B3C A;  1DQ7 A;  2E3G A;  1BMR A;  1GPS A;  1ZYW A;  1TI5 A;  1VNA A;  2N66 A;  4AAZ A;  1N4N A;  1ZFU A;  1T1T A;  1P0A A;  2NY9 X;  1AYJ A;  1CHZ A;  2KSK A;  2KYQ A;  1VNB A;  1T7A A;  2KGQ A;  4CQK A;  2ASC A;  4AEI A;  1SEG A;  1ZVG A;  1BK8 A;  1PE4 A;  1OMY A;  2A7T A;  2MZ0 A;  1ZUT A;  1LQH A;  1BRZ A;  1C56 A;  1I2U A;  1ZYV A;  1SN1 A;  1T7E A;  2LY6 A;  1SN4 A;  2NY8 X;  2LJ7 A;  1B3C A;  4AB0 A;  1WWN A;  3E7R L;  2LKB A;  2YBR C;  1NRA A;  2LT8 A;  1LQQ A;  2I61 A;  1L4V A;  2N2Q A;  1CN2 A;  2E0H A;  2LR3 A;  1JKZ A;  1MYN A;  2KBK A;  2SN3 A;  1NRB A;  2BRZ A;  1ZU3 A;  2B68 A;  1ICA A;  4HHF A;  1ZVE A;  1MR4 A;  2ATB A;  2N2R A;  1JZA A;  1NPI A;  2KBJ A;  4HE7 A;  2M8B B;  5CY0 A;  1AHO A;  2YEO A;  1JXC A;  1I6F A;  2LY5 A;  3E7U X;  1NE5 A;  1PTX A;  1KV0 A;  1P00 A;  2LJM A;  1OZZ A;  1WMT A;  1I2V A;  4UJ0 A;  2E3F A;  2KJA A;  1PX9 A;  4KYP A;  1FH3 A;  1JZB A;  3PSM A;  1LQI A; 
#chains in the Genus database with same CATH topology
 4H5R A;  5AQI A;  2LI7 A;  1DJT A;  3D2F A;  5FPM A;  3A8Y A;  1I6G A;  2GL1 A;  2MBK A;  1C55 A;  1B7D A;  1NGG A;  3BK3 C;  1NGB A;  2KBH A;  1BCG A;  3I33 A;  5AQS A;  1NGA A;  1NH5 A;  2YC1 C;  4FSV A;  3M3Z A;  4UAE F;  3QML A;  5KK4 A;  3AY9 A;  5AQG A;  1BUP A;  1HPM A;  3KOW A;  1GPT A;  1T7B A;  1WT7 A;  2E8A A;  1NGH A;  2KPY A;  2VY6 A;  1SNB A;  1T0Z A;  2N69 A;  2B3C A;  1DQ7 A;  2E3G A;  2YIL A;  3ATU A;  1ZYW A;  2QWO A;  3C7N B;  1TI5 A;  3KP0 A;  1BMR A;  1DKG D;  1GPS A;  1HJO A;  3KOX A;  1VNA A;  2N66 A;  2QWP A;  4KBO A;  1POI A;  2QWM A;  3FZH A;  3LDO A;  4AAZ A;  4H5T A;  5AQZ A;  5F1X A;  2E2F A;  2QW9 A;  3LDP A;  1KAX A;  1N4N A;  1ZFU A;  3FZM A;  3L56 A;  1T1T A;  3KOY A;  1P0A A;  1XRS B;  2NY9 X;  1AYJ A;  5AQR A;  1CHZ A;  2KSK A;  2KYQ A;  3KOZ A;  1BA0 A;  1VNB A;  1T7A A;  2K35 A;  2KGQ A;  3KVG A;  3LDL A;  4CQK A;  2ASC A;  5BPL A;  3L4I A;  1QQO A;  4AEI A;  3D2E A;  1SEG A;  1ZVG A;  1BK8 A;  1PE4 A;  1OMY A;  2QWL A;  1KAY A;  2A7T A;  2MZ0 A;  1ZUT A;  1LQH A;  1YUW A;  2QWQ A;  5AQX A;  5EXW A;  1NGD A;  5AQP A;  5AQW A;  1C56 A;  3R2V A;  5AQT A;  5FPD A;  1BRZ A;  1I2U A;  1ZYV A;  1SN1 A;  1T7E A;  2LY6 A;  3LDQ A;  5BN8 A;  1SN4 A;  2NY8 X;  2LJ7 A;  1B3C A;  3L6Q A;  1ATR A;  5EX5 A;  2JDQ D;  1BA1 A;  4AB0 A;  1WWN A;  3E7R L;  4H5N A;  2LKB A;  2YBR C;  4H5V A;  1NRA A;  2LT8 A;  3FE1 A;  3GL1 A;  1LQQ A;  4H5W A;  2I61 A;  1NGI A;  1L4V A;  3KC6 A;  3SF4 D;  1NGC A;  2N2Q A;  3KP1 A;  5BPN A;  1CN2 A;  5AQL A;  2E0H A;  3JXU A;  3D2F B;  4FL9 A;  5EVZ A;  2LR3 A;  1JKZ A;  1HX1 A;  5BN9 A;  1MYN A;  3KHW A;  2KBK A;  3QI7 A;  5AQU A;  3D2E B;  2SN3 A;  1NGJ A;  1QQM A;  1NRB A;  2QWR A;  2BRZ A;  5AQF A;  3C7N A;  2E88 A;  1ZU3 A;  2B68 A;  1ICA A;  3IUC A;  3FZK A;  5AQN A;  4UAD E;  4HHF A;  5AQV A;  1ZVE A;  1MR4 A;  1UGL A;  3CW4 A;  2ATB A;  2N2R A;  1JZA A;  1NPI A;  3ATV A;  2KBJ A;  4HE7 A;  2M8B B;  4GNI A;  5F0X A;  5CY0 A;  1AHO A;  5AQY A;  2MN5 A;  3GDQ A;  5AQO A;  5FPE A;  2YEO A;  1JXC A;  1I6F A;  2LY5 A;  3E7U X;  1NE5 A;  1PTX A;  3GKU A;  5AQJ A;  4V1D C;  1ATS A;  2D56 A;  2V7Z A;  1KV0 A;  1P00 A;  2QXL A;  3QFP A;  5AQM A;  2LJM A;  5FPN A;  5AR0 A;  1OZZ A;  2GMO A;  2LN8 A;  3FZF A;  5AQH A;  1WMT A;  1NGE A;  3QFU A;  4HWI A;  1I2V A;  3HSC A;  2BUP A;  4UJ0 A;  1S3X A;  2YIP A;  5BPM A;  2E3F A;  2KJA A;  3FZL A;  1PX9 A;  4KYP A;  5EY4 A;  5F2R A;  4IO8 A;  3LDN A;  1FH3 A;  1KAZ A;  1NGF A;  3CQX A;  1JZB A;  3PSM A;  1K8B A;  1LQI A;  4UAF E;  2QWN A;  2KHO A;  5AQK A;  1QQN A;  2YIO A;  2G2K A;  5AQQ A; 
#chains in the Genus database with same CATH homology
 2LI7 A;  1DJT A;  1I6G A;  2GL1 A;  1C55 A;  1B7D A;  2KBH A;  1BCG A;  1NH5 A;  2YC1 C;  5KK4 A;  1GPT A;  1T7B A;  1WT7 A;  2KPY A;  4V1D C;  1SNB A;  1T0Z A;  2N69 A;  2B3C A;  1DQ7 A;  2E3G A;  1BMR A;  1GPS A;  1ZYW A;  1TI5 A;  1VNA A;  2N66 A;  4AAZ A;  1N4N A;  1ZFU A;  1T1T A;  1P0A A;  2NY9 X;  1AYJ A;  1CHZ A;  2KSK A;  2KYQ A;  1VNB A;  1T7A A;  2KGQ A;  4CQK A;  2ASC A;  4AEI A;  1SEG A;  1ZVG A;  1BK8 A;  1PE4 A;  1OMY A;  2A7T A;  2MZ0 A;  1ZUT A;  1LQH A;  1BRZ A;  1C56 A;  1I2U A;  1ZYV A;  1SN1 A;  1T7E A;  2LY6 A;  1SN4 A;  2NY8 X;  2LJ7 A;  1B3C A;  4AB0 A;  1WWN A;  3E7R L;  2LKB A;  2YBR C;  1NRA A;  2LT8 A;  1LQQ A;  2I61 A;  1L4V A;  2N2Q A;  1CN2 A;  2E0H A;  2LR3 A;  1JKZ A;  1MYN A;  2KBK A;  2SN3 A;  1NRB A;  2BRZ A;  1ZU3 A;  2B68 A;  1ICA A;  4HHF A;  1ZVE A;  1MR4 A;  2ATB A;  2N2R A;  1JZA A;  1NPI A;  2KBJ A;  4HE7 A;  2M8B B;  5CY0 A;  1AHO A;  2YEO A;  1JXC A;  1I6F A;  2LY5 A;  3E7U X;  1NE5 A;  1PTX A;  1KV0 A;  1P00 A;  2LJM A;  1OZZ A;  1WMT A;  1I2V A;  4UJ0 A;  2E3F A;  2KJA A;  1PX9 A;  4KYP A;  1FH3 A;  1JZB A;  3PSM A;  1LQI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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