2I61A

Depressant anti-insect neurotoxin, lqhit2 from leiurus quinquestriatus hebraeus
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
62
structure length
62
Chain Sequence
MDGYIKRRDGCKVACLIGNEGCDKECKAYGGSYGYCWTWGLACWCEGLPDDKTWKSETNTCG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-ray Structure and Mutagenesis of the Scorpion Depressant Toxin LqhIT2 Reveals Key Determinants Crucial for Activity and Anti-Insect Selectivity.
pubmed doi rcsb
molecule tags Toxin
source organism Leiurus quinquestriatus hebraeus
molecule keywords Insect toxin 2
total genus 15
structure length 62
sequence length 62
ec nomenclature
pdb deposition date 2006-08-27
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.30.10 Alpha Beta 2-Layer Sandwich Defensin A-like Knottin, scorpion toxin-like 2i61A00
1NRAA 1VNAA 1WT7A 2LJ7A 1ZUTA 1T7BA 5KK4A 2YBRC 2KSKA 1L4VA 3E7UX 1LQIA 1AHOA 2KPYA 1T7EA 1GPTA 4AB0A 1SN4A 1T0ZA 2KJAA 1LQHA 4AEIA 2NY9X 2SN3A 1VNBA 1OMYA 1DQ7A 4V1DC 1NRBA 2LJMA 1NH5A 1ZFUA 2ATBA 2BRZA 1PE4A 2KBKA 1MYNA 1C56A 2A7TA 4HHFA 2N2RA 2KBJA 2NY8X 1ZVGA 1BK8A 1WWNA 1JZBA 3PSMA 1ZYWA 2B68A 4UJ0A 2I61A 2GL1A 1B7DA 5CY0A 1FH3A 2KYQA 1C55A 2N66A 1SEGA 1NE5A 1DJTA 2MZ0A 1JKZA 1I6GA 1BRZA 1N4NA 2E3GA 1B3CA 1JZAA 1MR4A 2YEOA 1KV0A 2LR3A 4AAZA 1ZVEA 1I6FA 1JXCA 1BMRA 2LT8A 2B3CA 2E0HA 1P00A 1ZYVA 4HE7A 1GPSA 1LQQA 2KBHA 2ASCA 2KGQA 1NPIA 2LI7A 1ZU3A 1I2VA 2M8BB 4CQKA 1P0AA 1CHZA 1SNBA 2LKBA 4KYPA 2N2QA 1PX9A 1OZZA 1ICAA 1PTXA 2LY6A 1BCGA 1WMTA 2LY5A 1SN1A 1T7AA 3E7RL 1T1TA 2N69A 1AYJA 1I2UA 1CN2A 1TI5A 2E3FA 2YC1C
chains in the Genus database with same CATH superfamily
1NRAA 1VNAA 1S3XA 1WT7A 2LJ7A 5F0XA 1ZUTA 1T7BA 5AQPA 5KK4A 2BUPA 2YBRC 2KSKA 1L4VA 3FZMA 3E7UX 1LQIA 5AQGA 2MN5A 1AHOA 1HJOA 2KPYA 2QWPA 1T7EA 4FL9A 1GPTA 4AB0A 1SN4A 2E2FA 3ATVA 3QFUA 1T0ZA 2KJAA 5AQWA 2GMOA 5EY4A 1LQHA 2K35A 2NY9X 5AQHA 3KVGA 4AEIA 3KP0A 5AQKA 2SN3A 5EVZA 5AQMA 1NGFA 3A8YA 1VNBA 3KOXA 1ATSA 1QQMA 3L6QA 4UAEF 5EXWA 1HX1A 5AQUA 1OMYA 1DQ7A 5AQVA 4IO8A 3GDQA 1NGBA 4V1DC 1NRBA 5AQZA 2YIOA 3LDPA 4H5RA 1NGJA 1NGAA 1NH5A 2LJMA 2QWMA 3ATUA 5BN9A 3FE1A 1BA0A 1ZFUA 3D2EA 3R2VA 2ATBA 2BRZA 1PE4A 2D56A 2KBKA 2KHOA 2MBKA 4GNIA 1MYNA 3C7NA 5F1XA 3I33A 1NGHA 5AR0A 1NGGA 3FZFA 5BPMA 2QWQA 1C56A 2A7TA 4HHFA 2N2RA 3D2FA 3FZKA 2KBJA 2JDQD 1DKGD 3L4IA 5AQJA 5AQLA 3HSCA 2NY8X 5AQNA 1ZVGA 1BK8A 1WWNA 1JZBA 1HPMA 3PSMA 1ZYWA 2B68A 4UJ0A 2I61A 1YUWA 2QXLA 2GL1A 1B7DA 5CY0A 1FH3A 2KYQA 1C55A 2YIPA 2N66A 5AQSA 1SEGA 3KOYA 4H5VA 1K8BA 1NE5A 2G2KA 1BA1A 1KAZA 1DJTA 2MZ0A 3QI7A 3JXUA 2E8AA 5FPDA 1JKZA 1I6GA 3C7NB 1BRZA 1N4NA 2E3GA 5BPLA 1B3CA 1JZAA 1KAXA 3CQXA 1MR4A 3KOZA 3LDLA 2YEOA 1KV0A 2QWNA 2VY6A 2LR3A 3KHWA 3FZLA 3QMLA 1NGIA 1ZVEA 4AAZA 1QQNA 5BPNA 2QWOA 3L56A 5AQTA 1I6FA 4UAFE 4HWIA 1JXCA 1BMRA 2LT8A 4H5NA 2B3CA 2E0HA 3AY9A 4KBOA 5FPEA 1P00A 1ZYVA 4HE7A 3KOWA 1GPSA 1LQQA 2ASCA 2KBHA 2KGQA 1NPIA 2LI7A 3KP1A 5FPNA 2V7ZA 4UADE 3D2EB 2QWRA 1ZU3A 4H5TA 1I2VA 2LN8A 2M8BB 4CQKA 1ATRA 1P0AA 1KAYA 2QW9A 1CHZA 1SNBA 3SF4D 5AQQA 1NGDA 3LDOA 5AQYA 5AQIA 5AQRA 2LKBA 4KYPA 3KC6A 1BUPA 2N2QA 5AQOA 3D2FB 1PX9A 3FZHA 3IUCA 1OZZA 3M3ZA 1POIA 3GL1A 3BK3C 4FSVA 1QQOA 1ICAA 2QWLA 3LDNA 2YILA 1PTXA 1XRSB 1BCGA 1WMTA 1NGEA 2LY5A 1SN1A 2LY6A 5F2RA 1NGCA 5FPMA 1T7AA 3E7RL 1T1TA 2N69A 3QFPA 3CW4A 5AQFA 3LDQA 1UGLA 5AQXA 5EX5A 1AYJA 4H5WA 1I2UA 5BN8A 1CN2A 1TI5A 3GKUA 2E88A 2E3FA 2YC1C
chains in the Genus database with same CATH topology
1NRAA 1VNAA 1WT7A 2LJ7A 1ZUTA 1T7BA 5KK4A 2YBRC 2KSKA 1L4VA 3E7UX 1LQIA 1AHOA 2KPYA 1T7EA 1GPTA 4AB0A 1SN4A 1T0ZA 2KJAA 1LQHA 4AEIA 2NY9X 2SN3A 1VNBA 1OMYA 1DQ7A 4V1DC 1NRBA 2LJMA 1NH5A 1ZFUA 2ATBA 2BRZA 1PE4A 2KBKA 1MYNA 1C56A 2A7TA 4HHFA 2N2RA 2KBJA 2NY8X 1ZVGA 1BK8A 1WWNA 1JZBA 3PSMA 1ZYWA 2B68A 4UJ0A 2I61A 2GL1A 1B7DA 5CY0A 1FH3A 2KYQA 1C55A 2N66A 1SEGA 1NE5A 1DJTA 2MZ0A 1JKZA 1I6GA 1BRZA 1N4NA 2E3GA 1B3CA 1JZAA 1MR4A 2YEOA 1KV0A 2LR3A 4AAZA 1ZVEA 1I6FA 1JXCA 1BMRA 2LT8A 2B3CA 2E0HA 1P00A 1ZYVA 4HE7A 1GPSA 1LQQA 2KBHA 2ASCA 2KGQA 1NPIA 2LI7A 1ZU3A 1I2VA 2M8BB 4CQKA 1P0AA 1CHZA 1SNBA 2LKBA 4KYPA 2N2QA 1PX9A 1OZZA 1ICAA 1PTXA 2LY6A 1BCGA 1WMTA 2LY5A 1SN1A 1T7AA 3E7RL 1T1TA 2N69A 1AYJA 1I2UA 1CN2A 1TI5A 2E3FA 2YC1C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NRA A;  1VNA A;  1WT7 A;  2LJ7 A;  1ZUT A;  1T7B A;  5KK4 A;  2YBR C;  2KSK A;  1L4V A;  3E7U X;  1LQI A;  1AHO A;  2KPY A;  1T7E A;  1GPT A;  4AB0 A;  1SN4 A;  1T0Z A;  2KJA A;  1LQH A;  4AEI A;  2NY9 X;  2SN3 A;  1VNB A;  1OMY A;  1DQ7 A;  4V1D C;  1NRB A;  2LJM A;  1NH5 A;  1ZFU A;  2ATB A;  2BRZ A;  1PE4 A;  2KBK A;  1MYN A;  1C56 A;  2A7T A;  4HHF A;  2N2R A;  2KBJ A;  2NY8 X;  1ZVG A;  1BK8 A;  1WWN A;  1JZB A;  3PSM A;  1ZYW A;  2B68 A;  4UJ0 A;  2I61 A;  2GL1 A;  1B7D A;  5CY0 A;  1FH3 A;  2KYQ A;  1C55 A;  2N66 A;  1SEG A;  1NE5 A;  1DJT A;  2MZ0 A;  1JKZ A;  1I6G A;  1BRZ A;  1N4N A;  2E3G A;  1B3C A;  1JZA A;  1MR4 A;  2YEO A;  1KV0 A;  2LR3 A;  4AAZ A;  1ZVE A;  1I6F A;  1JXC A;  1BMR A;  2LT8 A;  2B3C A;  2E0H A;  1P00 A;  1ZYV A;  4HE7 A;  1GPS A;  1LQQ A;  2KBH A;  2ASC A;  2KGQ A;  1NPI A;  2LI7 A;  1ZU3 A;  1I2V A;  2M8B B;  4CQK A;  1P0A A;  1CHZ A;  1SNB A;  2LKB A;  4KYP A;  2N2Q A;  1PX9 A;  1OZZ A;  1ICA A;  1PTX A;  2LY6 A;  1BCG A;  1WMT A;  2LY5 A;  1SN1 A;  1T7A A;  3E7R L;  1T1T A;  2N69 A;  1AYJ A;  1I2U A;  1CN2 A;  1TI5 A;  2E3F A;  2YC1 C; 
#chains in the Genus database with same CATH topology
 1NRA A;  1VNA A;  1S3X A;  1WT7 A;  2LJ7 A;  5F0X A;  1ZUT A;  1T7B A;  5AQP A;  5KK4 A;  2BUP A;  2YBR C;  2KSK A;  1L4V A;  3FZM A;  3E7U X;  1LQI A;  5AQG A;  2MN5 A;  1AHO A;  1HJO A;  2KPY A;  2QWP A;  1T7E A;  4FL9 A;  1GPT A;  4AB0 A;  1SN4 A;  2E2F A;  3ATV A;  3QFU A;  1T0Z A;  2KJA A;  5AQW A;  2GMO A;  5EY4 A;  1LQH A;  2K35 A;  2NY9 X;  5AQH A;  3KVG A;  4AEI A;  3KP0 A;  5AQK A;  2SN3 A;  5EVZ A;  5AQM A;  1NGF A;  3A8Y A;  1VNB A;  3KOX A;  1ATS A;  1QQM A;  3L6Q A;  4UAE F;  5EXW A;  1HX1 A;  5AQU A;  1OMY A;  1DQ7 A;  5AQV A;  4IO8 A;  3GDQ A;  1NGB A;  4V1D C;  1NRB A;  5AQZ A;  2YIO A;  3LDP A;  4H5R A;  1NGJ A;  1NGA A;  1NH5 A;  2LJM A;  2QWM A;  3ATU A;  5BN9 A;  3FE1 A;  1BA0 A;  1ZFU A;  3D2E A;  3R2V A;  2ATB A;  2BRZ A;  1PE4 A;  2D56 A;  2KBK A;  2KHO A;  2MBK A;  4GNI A;  1MYN A;  3C7N A;  5F1X A;  3I33 A;  1NGH A;  5AR0 A;  1NGG A;  3FZF A;  5BPM A;  2QWQ A;  1C56 A;  2A7T A;  4HHF A;  2N2R A;  3D2F A;  3FZK A;  2KBJ A;  2JDQ D;  1DKG D;  3L4I A;  5AQJ A;  5AQL A;  3HSC A;  2NY8 X;  5AQN A;  1ZVG A;  1BK8 A;  1WWN A;  1JZB A;  1HPM A;  3PSM A;  1ZYW A;  2B68 A;  4UJ0 A;  2I61 A;  1YUW A;  2QXL A;  2GL1 A;  1B7D A;  5CY0 A;  1FH3 A;  2KYQ A;  1C55 A;  2YIP A;  2N66 A;  5AQS A;  1SEG A;  3KOY A;  4H5V A;  1K8B A;  1NE5 A;  2G2K A;  1BA1 A;  1KAZ A;  1DJT A;  2MZ0 A;  3QI7 A;  3JXU A;  2E8A A;  5FPD A;  1JKZ A;  1I6G A;  3C7N B;  1BRZ A;  1N4N A;  2E3G A;  5BPL A;  1B3C A;  1JZA A;  1KAX A;  3CQX A;  1MR4 A;  3KOZ A;  3LDL A;  2YEO A;  1KV0 A;  2QWN A;  2VY6 A;  2LR3 A;  3KHW A;  3FZL A;  3QML A;  1NGI A;  1ZVE A;  4AAZ A;  1QQN A;  5BPN A;  2QWO A;  3L56 A;  5AQT A;  1I6F A;  4UAF E;  4HWI A;  1JXC A;  1BMR A;  2LT8 A;  4H5N A;  2B3C A;  2E0H A;  3AY9 A;  4KBO A;  5FPE A;  1P00 A;  1ZYV A;  4HE7 A;  3KOW A;  1GPS A;  1LQQ A;  2ASC A;  2KBH A;  2KGQ A;  1NPI A;  2LI7 A;  3KP1 A;  5FPN A;  2V7Z A;  4UAD E;  3D2E B;  2QWR A;  1ZU3 A;  4H5T A;  1I2V A;  2LN8 A;  2M8B B;  4CQK A;  1ATR A;  1P0A A;  1KAY A;  2QW9 A;  1CHZ A;  1SNB A;  3SF4 D;  5AQQ A;  1NGD A;  3LDO A;  5AQY A;  5AQI A;  5AQR A;  2LKB A;  4KYP A;  3KC6 A;  1BUP A;  2N2Q A;  5AQO A;  3D2F B;  1PX9 A;  3FZH A;  3IUC A;  1OZZ A;  3M3Z A;  1POI A;  3GL1 A;  3BK3 C;  4FSV A;  1QQO A;  1ICA A;  2QWL A;  3LDN A;  2YIL A;  1PTX A;  1XRS B;  1BCG A;  1WMT A;  1NGE A;  2LY5 A;  1SN1 A;  2LY6 A;  5F2R A;  1NGC A;  5FPM A;  1T7A A;  3E7R L;  1T1T A;  2N69 A;  3QFP A;  3CW4 A;  5AQF A;  3LDQ A;  1UGL A;  5AQX A;  5EX5 A;  1AYJ A;  4H5W A;  1I2U A;  5BN8 A;  1CN2 A;  1TI5 A;  3GKU A;  2E88 A;  2E3F A;  2YC1 C; 
#chains in the Genus database with same CATH homology
 1NRA A;  1VNA A;  1WT7 A;  2LJ7 A;  1ZUT A;  1T7B A;  5KK4 A;  2YBR C;  2KSK A;  1L4V A;  3E7U X;  1LQI A;  1AHO A;  2KPY A;  1T7E A;  1GPT A;  4AB0 A;  1SN4 A;  1T0Z A;  2KJA A;  1LQH A;  4AEI A;  2NY9 X;  2SN3 A;  1VNB A;  1OMY A;  1DQ7 A;  4V1D C;  1NRB A;  2LJM A;  1NH5 A;  1ZFU A;  2ATB A;  2BRZ A;  1PE4 A;  2KBK A;  1MYN A;  1C56 A;  2A7T A;  4HHF A;  2N2R A;  2KBJ A;  2NY8 X;  1ZVG A;  1BK8 A;  1WWN A;  1JZB A;  3PSM A;  1ZYW A;  2B68 A;  4UJ0 A;  2I61 A;  2GL1 A;  1B7D A;  5CY0 A;  1FH3 A;  2KYQ A;  1C55 A;  2N66 A;  1SEG A;  1NE5 A;  1DJT A;  2MZ0 A;  1JKZ A;  1I6G A;  1BRZ A;  1N4N A;  2E3G A;  1B3C A;  1JZA A;  1MR4 A;  2YEO A;  1KV0 A;  2LR3 A;  4AAZ A;  1ZVE A;  1I6F A;  1JXC A;  1BMR A;  2LT8 A;  2B3C A;  2E0H A;  1P00 A;  1ZYV A;  4HE7 A;  1GPS A;  1LQQ A;  2KBH A;  2ASC A;  2KGQ A;  1NPI A;  2LI7 A;  1ZU3 A;  1I2V A;  2M8B B;  4CQK A;  1P0A A;  1CHZ A;  1SNB A;  2LKB A;  4KYP A;  2N2Q A;  1PX9 A;  1OZZ A;  1ICA A;  1PTX A;  2LY6 A;  1BCG A;  1WMT A;  2LY5 A;  1SN1 A;  1T7A A;  3E7R L;  1T1T A;  2N69 A;  1AYJ A;  1I2U A;  1CN2 A;  1TI5 A;  2E3F A;  2YC1 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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