2I61A

Depressant anti-insect neurotoxin, lqhit2 from leiurus quinquestriatus hebraeus
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
62
structure length
62
Chain Sequence
MDGYIKRRDGCKVACLIGNEGCDKECKAYGGSYGYCWTWGLACWCEGLPDDKTWKSETNTCG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-ray Structure and Mutagenesis of the Scorpion Depressant Toxin LqhIT2 Reveals Key Determinants Crucial for Activity and Anti-Insect Selectivity.
pubmed doi rcsb
molecule tags Toxin
source organism Leiurus quinquestriatus hebraeus
molecule keywords Insect toxin 2
total genus 15
structure length 62
sequence length 62
ec nomenclature
pdb deposition date 2006-08-27
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.30.10 Alpha Beta 2-Layer Sandwich Defensin A-like Knottin, scorpion toxin-like 2i61A00
1SN4A 2B3CA 1I6GA 1NRAA 5KK4A 1WT7A 2MZ0A 2LKBA 1JZAA 1SEGA 2N2QA 1LQQA 1BCGA 1T0ZA 2NY8X 2LY6A 1SN1A 4HHFA 1AYJA 1B7DA 1N4NA 4AB0A 2B68A 2NY9X 2M8BB 2N69A 3E7UX 1CN2A 2LR3A 2KPYA 2LJ7A 2KGQA 1GPTA 2KJAA 2KBHA 1P00A 2KBJA 2YC1C 2I61A 2ASCA 4AAZA 1JXCA 1ZVEA 4CQKA 1ZUTA 4AEIA 1ZFUA 2KYQA 2YEOA 1VNBA 4V1DC 1C55A 1NE5A 2LI7A 2ATBA 2LT8A 1P0AA 1NH5A 1PX9A 2N2RA 1OZZA 1WMTA 1MR4A 4KYPA 4HE7A 2LY5A 1ZYVA 5CY0A 1PTXA 1TI5A 1AHOA 1NPIA 1ICAA 2A7TA 1T7EA 1JZBA 2E3FA 1LQHA 1VNAA 1BK8A 1DJTA 1WWNA 2E0HA 2SN3A 3E7RL 1ZYWA 1B3CA 1T7BA 2KSKA 2KBKA 1MYNA 1LQIA 2GL1A 1PE4A 1C56A 3PSMA 1T7AA 1KV0A 1NRBA 1BMRA 1I2UA 1SNBA 2YBRC 1BRZA 1JKZA 1I2VA 1FH3A 2E3GA 1ZU3A 1DQ7A 1OMYA 1ZVGA 1GPSA 1CHZA 2BRZA 2N66A 2LJMA 4UJ0A 1T1TA 1I6FA 1L4VA
chains in the Genus database with same CATH superfamily
1NGDA 1SN4A 2B3CA 1I6GA 1NRAA 1QQNA 1NGFA 3CW4A 5AQLA 5F1XA 5KK4A 1WT7A 1XRSB 3ATVA 2MZ0A 2LKBA 3JXUA 3KOXA 1JZAA 3A8YA 3R2VA 1SEGA 3I33A 2N2QA 3CQXA 1LQQA 3IUCA 1BCGA 1KAYA 1S3XA 1T0ZA 2NY8X 4H5NA 1QQMA 1SN1A 2E88A 2LY6A 4HHFA 1AYJA 1B7DA 2QWQA 3C7NB 2D56A 5EVZA 1N4NA 4AB0A 2B68A 2KHOA 3HSCA 5AQRA 2NY9X 1HJOA 1KAXA 3FE1A 2M8BB 3L4IA 2N69A 3E7UX 5BPNA 3C7NA 1NGHA 3SF4D 1CN2A 3FZFA 2LR3A 1NGBA 2KPYA 2LJ7A 3KHWA 2KGQA 5BN9A 1GPTA 2KJAA 3D2FA 2KBHA 3QI7A 1HPMA 1P00A 2KBJA 2YC1C 1BA1A 5AQHA 5AQMA 2I61A 3KOYA 2ASCA 1BA0A 4AAZA 1JXCA 1NGJA 1ZVEA 2BUPA 3L56A 2QW9A 2V7ZA 3KOZA 1ZUTA 5AQOA 4CQKA 4H5VA 2LN8A 2QWRA 2YILA 4AEIA 3QFUA 5EXWA 5AQFA 2JDQD 1ATRA 1ZFUA 2KYQA 1VNBA 2YEOA 2MBKA 3KP1A 4V1DC 1NE5A 1C55A 2LI7A 2ATBA 2LT8A 1P0AA 2E2FA 3LDLA 3KOWA 1NH5A 1PX9A 2GMOA 1UGLA 2N2RA 1YUWA 1OZZA 3D2FB 3L6QA 3LDQA 1WMTA 4H5WA 1MR4A 5AQPA 5FPMA 3M3ZA 4KYPA 4HE7A 2YIOA 5AQJA 4FL9A 3GKUA 5F0XA 5FPNA 2LY5A 1ZYVA 3LDPA 5F2RA 5CY0A 1PTXA 5AQTA 1TI5A 4UADE 1AHOA 1NPIA 3FZMA 3KC6A 1ICAA 1BUPA 1NGGA 2A7TA 5AQGA 1T7EA 5AQXA 1JZBA 2E3FA 2QWLA 4HWIA 1LQHA 5EY4A 4H5RA 1VNAA 1BK8A 3KP0A 5AQIA 1DJTA 3GL1A 1WWNA 2E0HA 2SN3A 2G2KA 1ZYWA 3E7RL 5AQUA 1B3CA 2QXLA 1T7BA 3BK3C 5AQWA 2KSKA 3FZLA 3ATUA 1POIA 3GDQA 2VY6A 1QQOA 2KBKA 2QWOA 5BN8A 1MYNA 5AQYA 1LQIA 2GL1A 5AQVA 5EX5A 3QMLA 5AQZA 1KAZA 1PE4A 1C56A 3PSMA 1NGIA 1T7AA 2E8AA 2K35A 2QWMA 3LDNA 3QFPA 4GNIA 1KV0A 1NRBA 3D2EB 3FZKA 5AQKA 1NGAA 4UAFE 1BMRA 3LDOA 4KBOA 3FZHA 5AQNA 5BPLA 1I2UA 1DKGD 2QWPA 5FPDA 5AQSA 1SNBA 5BPMA 2YBRC 1BRZA 3D2EA 1JKZA 1I2VA 1FH3A 2E3GA 3KVGA 4FSVA 2QWNA 1ZU3A 3AY9A 1DQ7A 1OMYA 1ZVGA 2YIPA 5AQQA 1CHZA 1GPSA 5FPEA 1HX1A 1NGCA 5AR0A 2MN5A 1NGEA 2BRZA 2N66A 2LJMA 4UJ0A 1T1TA 1ATSA 1I6FA 1K8BA 1L4VA 4IO8A 4UAEF 4H5TA
chains in the Genus database with same CATH topology
1SN4A 2B3CA 1I6GA 1NRAA 5KK4A 1WT7A 2MZ0A 2LKBA 1JZAA 1SEGA 2N2QA 1LQQA 1BCGA 1T0ZA 2NY8X 2LY6A 1SN1A 4HHFA 1AYJA 1B7DA 1N4NA 4AB0A 2B68A 2NY9X 2M8BB 2N69A 3E7UX 1CN2A 2LR3A 2KPYA 2LJ7A 2KGQA 1GPTA 2KJAA 2KBHA 1P00A 2KBJA 2YC1C 2I61A 2ASCA 4AAZA 1JXCA 1ZVEA 4CQKA 1ZUTA 4AEIA 1ZFUA 2KYQA 2YEOA 1VNBA 4V1DC 1C55A 1NE5A 2LI7A 2ATBA 2LT8A 1P0AA 1NH5A 1PX9A 2N2RA 1OZZA 1WMTA 1MR4A 4KYPA 4HE7A 2LY5A 1ZYVA 5CY0A 1PTXA 1TI5A 1AHOA 1NPIA 1ICAA 2A7TA 1T7EA 1JZBA 2E3FA 1LQHA 1VNAA 1BK8A 1DJTA 1WWNA 2E0HA 2SN3A 3E7RL 1ZYWA 1B3CA 1T7BA 2KSKA 2KBKA 1MYNA 1LQIA 2GL1A 1PE4A 1C56A 3PSMA 1T7AA 1KV0A 1NRBA 1BMRA 1I2UA 1SNBA 2YBRC 1BRZA 1JKZA 1I2VA 1FH3A 2E3GA 1ZU3A 1DQ7A 1OMYA 1ZVGA 1GPSA 1CHZA 2BRZA 2N66A 2LJMA 4UJ0A 1T1TA 1I6FA 1L4VA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SN4 A;  2B3C A;  1I6G A;  1NRA A;  5KK4 A;  1WT7 A;  2MZ0 A;  2LKB A;  1JZA A;  1SEG A;  2N2Q A;  1LQQ A;  1BCG A;  1T0Z A;  2NY8 X;  2LY6 A;  1SN1 A;  4HHF A;  1AYJ A;  1B7D A;  1N4N A;  4AB0 A;  2B68 A;  2NY9 X;  2M8B B;  2N69 A;  3E7U X;  1CN2 A;  2LR3 A;  2KPY A;  2LJ7 A;  2KGQ A;  1GPT A;  2KJA A;  2KBH A;  1P00 A;  2KBJ A;  2YC1 C;  2I61 A;  2ASC A;  4AAZ A;  1JXC A;  1ZVE A;  4CQK A;  1ZUT A;  4AEI A;  1ZFU A;  2KYQ A;  2YEO A;  1VNB A;  4V1D C;  1C55 A;  1NE5 A;  2LI7 A;  2ATB A;  2LT8 A;  1P0A A;  1NH5 A;  1PX9 A;  2N2R A;  1OZZ A;  1WMT A;  1MR4 A;  4KYP A;  4HE7 A;  2LY5 A;  1ZYV A;  5CY0 A;  1PTX A;  1TI5 A;  1AHO A;  1NPI A;  1ICA A;  2A7T A;  1T7E A;  1JZB A;  2E3F A;  1LQH A;  1VNA A;  1BK8 A;  1DJT A;  1WWN A;  2E0H A;  2SN3 A;  3E7R L;  1ZYW A;  1B3C A;  1T7B A;  2KSK A;  2KBK A;  1MYN A;  1LQI A;  2GL1 A;  1PE4 A;  1C56 A;  3PSM A;  1T7A A;  1KV0 A;  1NRB A;  1BMR A;  1I2U A;  1SNB A;  2YBR C;  1BRZ A;  1JKZ A;  1I2V A;  1FH3 A;  2E3G A;  1ZU3 A;  1DQ7 A;  1OMY A;  1ZVG A;  1GPS A;  1CHZ A;  2BRZ A;  2N66 A;  2LJM A;  4UJ0 A;  1T1T A;  1I6F A;  1L4V A; 
#chains in the Genus database with same CATH topology
 1NGD A;  1SN4 A;  2B3C A;  1I6G A;  1NRA A;  1QQN A;  1NGF A;  3CW4 A;  5AQL A;  5F1X A;  5KK4 A;  1WT7 A;  1XRS B;  3ATV A;  2MZ0 A;  2LKB A;  3JXU A;  3KOX A;  1JZA A;  3A8Y A;  3R2V A;  1SEG A;  3I33 A;  2N2Q A;  3CQX A;  1LQQ A;  3IUC A;  1BCG A;  1KAY A;  1S3X A;  1T0Z A;  2NY8 X;  4H5N A;  1QQM A;  1SN1 A;  2E88 A;  2LY6 A;  4HHF A;  1AYJ A;  1B7D A;  2QWQ A;  3C7N B;  2D56 A;  5EVZ A;  1N4N A;  4AB0 A;  2B68 A;  2KHO A;  3HSC A;  5AQR A;  2NY9 X;  1HJO A;  1KAX A;  3FE1 A;  2M8B B;  3L4I A;  2N69 A;  3E7U X;  5BPN A;  3C7N A;  1NGH A;  3SF4 D;  1CN2 A;  3FZF A;  2LR3 A;  1NGB A;  2KPY A;  2LJ7 A;  3KHW A;  2KGQ A;  5BN9 A;  1GPT A;  2KJA A;  3D2F A;  2KBH A;  3QI7 A;  1HPM A;  1P00 A;  2KBJ A;  2YC1 C;  1BA1 A;  5AQH A;  5AQM A;  2I61 A;  3KOY A;  2ASC A;  1BA0 A;  4AAZ A;  1JXC A;  1NGJ A;  1ZVE A;  2BUP A;  3L56 A;  2QW9 A;  2V7Z A;  3KOZ A;  1ZUT A;  5AQO A;  4CQK A;  4H5V A;  2LN8 A;  2QWR A;  2YIL A;  4AEI A;  3QFU A;  5EXW A;  5AQF A;  2JDQ D;  1ATR A;  1ZFU A;  2KYQ A;  1VNB A;  2YEO A;  2MBK A;  3KP1 A;  4V1D C;  1NE5 A;  1C55 A;  2LI7 A;  2ATB A;  2LT8 A;  1P0A A;  2E2F A;  3LDL A;  3KOW A;  1NH5 A;  1PX9 A;  2GMO A;  1UGL A;  2N2R A;  1YUW A;  1OZZ A;  3D2F B;  3L6Q A;  3LDQ A;  1WMT A;  4H5W A;  1MR4 A;  5AQP A;  5FPM A;  3M3Z A;  4KYP A;  4HE7 A;  2YIO A;  5AQJ A;  4FL9 A;  3GKU A;  5F0X A;  5FPN A;  2LY5 A;  1ZYV A;  3LDP A;  5F2R A;  5CY0 A;  1PTX A;  5AQT A;  1TI5 A;  4UAD E;  1AHO A;  1NPI A;  3FZM A;  3KC6 A;  1ICA A;  1BUP A;  1NGG A;  2A7T A;  5AQG A;  1T7E A;  5AQX A;  1JZB A;  2E3F A;  2QWL A;  4HWI A;  1LQH A;  5EY4 A;  4H5R A;  1VNA A;  1BK8 A;  3KP0 A;  5AQI A;  1DJT A;  3GL1 A;  1WWN A;  2E0H A;  2SN3 A;  2G2K A;  1ZYW A;  3E7R L;  5AQU A;  1B3C A;  2QXL A;  1T7B A;  3BK3 C;  5AQW A;  2KSK A;  3FZL A;  3ATU A;  1POI A;  3GDQ A;  2VY6 A;  1QQO A;  2KBK A;  2QWO A;  5BN8 A;  1MYN A;  5AQY A;  1LQI A;  2GL1 A;  5AQV A;  5EX5 A;  3QML A;  5AQZ A;  1KAZ A;  1PE4 A;  1C56 A;  3PSM A;  1NGI A;  1T7A A;  2E8A A;  2K35 A;  2QWM A;  3LDN A;  3QFP A;  4GNI A;  1KV0 A;  1NRB A;  3D2E B;  3FZK A;  5AQK A;  1NGA A;  4UAF E;  1BMR A;  3LDO A;  4KBO A;  3FZH A;  5AQN A;  5BPL A;  1I2U A;  1DKG D;  2QWP A;  5FPD A;  5AQS A;  1SNB A;  5BPM A;  2YBR C;  1BRZ A;  3D2E A;  1JKZ A;  1I2V A;  1FH3 A;  2E3G A;  3KVG A;  4FSV A;  2QWN A;  1ZU3 A;  3AY9 A;  1DQ7 A;  1OMY A;  1ZVG A;  2YIP A;  5AQQ A;  1CHZ A;  1GPS A;  5FPE A;  1HX1 A;  1NGC A;  5AR0 A;  2MN5 A;  1NGE A;  2BRZ A;  2N66 A;  2LJM A;  4UJ0 A;  1T1T A;  1ATS A;  1I6F A;  1K8B A;  1L4V A;  4IO8 A;  4UAE F;  4H5T A; 
#chains in the Genus database with same CATH homology
 1SN4 A;  2B3C A;  1I6G A;  1NRA A;  5KK4 A;  1WT7 A;  2MZ0 A;  2LKB A;  1JZA A;  1SEG A;  2N2Q A;  1LQQ A;  1BCG A;  1T0Z A;  2NY8 X;  2LY6 A;  1SN1 A;  4HHF A;  1AYJ A;  1B7D A;  1N4N A;  4AB0 A;  2B68 A;  2NY9 X;  2M8B B;  2N69 A;  3E7U X;  1CN2 A;  2LR3 A;  2KPY A;  2LJ7 A;  2KGQ A;  1GPT A;  2KJA A;  2KBH A;  1P00 A;  2KBJ A;  2YC1 C;  2I61 A;  2ASC A;  4AAZ A;  1JXC A;  1ZVE A;  4CQK A;  1ZUT A;  4AEI A;  1ZFU A;  2KYQ A;  2YEO A;  1VNB A;  4V1D C;  1C55 A;  1NE5 A;  2LI7 A;  2ATB A;  2LT8 A;  1P0A A;  1NH5 A;  1PX9 A;  2N2R A;  1OZZ A;  1WMT A;  1MR4 A;  4KYP A;  4HE7 A;  2LY5 A;  1ZYV A;  5CY0 A;  1PTX A;  1TI5 A;  1AHO A;  1NPI A;  1ICA A;  2A7T A;  1T7E A;  1JZB A;  2E3F A;  1LQH A;  1VNA A;  1BK8 A;  1DJT A;  1WWN A;  2E0H A;  2SN3 A;  3E7R L;  1ZYW A;  1B3C A;  1T7B A;  2KSK A;  2KBK A;  1MYN A;  1LQI A;  2GL1 A;  1PE4 A;  1C56 A;  3PSM A;  1T7A A;  1KV0 A;  1NRB A;  1BMR A;  1I2U A;  1SNB A;  2YBR C;  1BRZ A;  1JKZ A;  1I2V A;  1FH3 A;  2E3G A;  1ZU3 A;  1DQ7 A;  1OMY A;  1ZVG A;  1GPS A;  1CHZ A;  2BRZ A;  2N66 A;  2LJM A;  4UJ0 A;  1T1T A;  1I6F A;  1L4V A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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