2LKBA

Evolutionary diversification of mesobuthus alpha-scorpion toxins affecting sodium channels
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
66
structure length
66
Chain Sequence
ARDAYIAKPHNCVYECFDAFSSYCNGVCTKNGAKSGYCQILGTYGNGCWCIALPDNVPIRIPGKCH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Evolutionary diversification of Mesobuthus {alpha}-scorpion toxins affecting sodium channels
pubmed doi rcsb
molecule tags Toxin
molecule keywords Neurotoxin MeuNaTx-5
total genus 9
structure length 66
sequence length 66
ec nomenclature
pdb deposition date 2011-10-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00537 Toxin_3 Scorpion toxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.30.10 Alpha Beta 2-Layer Sandwich Defensin A-like Knottin, scorpion toxin-like 2lkbA00
1WWNA 1BCGA 1PE4A 2KBHA 1ZU3A 2E3FA 4CQKA 4AB0A 3E7RL 1PTXA 2N69A 1C56A 2KJAA 1ZVGA 2ATBA 1BRZA 2E0HA 2KPYA 4KYPA 5CY0A 1ZYWA 1VNAA 2M8BB 1T0ZA 1T7BA 1I6GA 1BK8A 1SN4A 1BMRA 2YBRC 2LI7A 1NH5A 2BRZA 1ZFUA 1GPTA 2LT8A 2E3GA 2LKBA 2NY9X 5KK4A 1C55A 2KBKA 2KGQA 2A7TA 1SN1A 1NPIA 2I61A 2LY5A 1JKZA 1DQ7A 1LQQA 1LQHA 2LY6A 2B3CA 2N66A 2SN3A 1DJTA 1CHZA 4AAZA 2LR3A 1FH3A 1T7EA 1ZYVA 1SEGA 1MYNA 1AYJA 3PSMA 1GPSA 1CN2A 2GL1A 2N2RA 1I2UA 1OZZA 1WT7A 2KYQA 1P0AA 1I2VA 1ZUTA 1MR4A 2LJMA 1JZBA 1B3CA 1P00A 1OMYA 1WMTA 1JXCA 1AHOA 4AEIA 2YC1C 1L4VA 1NE5A 1LQIA 1JZAA 1VNBA 4V1DC 2MZ0A 2B68A 1T7AA 3E7UX 1SNBA 2YEOA 1I6FA 4HHFA 2KSKA 4HE7A 1KV0A 2KBJA 2LJ7A 1NRAA 1TI5A 1B7DA 1NRBA 2N2QA 1PX9A 2NY8X 1T1TA 1N4NA 4UJ0A 2ASCA 1ZVEA 1ICAA
chains in the Genus database with same CATH superfamily
1WWNA 1BCGA 1KAXA 2QW9A 3M3ZA 5AQGA 1PE4A 5BN8A 2KBHA 5AQWA 3D2EB 1ZU3A 3HSCA 2E3FA 3CW4A 1HX1A 5FPNA 4CQKA 4AB0A 3CQXA 1PTXA 2YIOA 3E7RL 4GNIA 4FSVA 5EXWA 4UAFE 2G2KA 4UADE 3FZKA 1HPMA 2N69A 2QWLA 5BPLA 1C56A 2KJAA 1ZVGA 2ATBA 3QMLA 1BRZA 2YILA 1K8BA 3KOXA 3L4IA 2E0HA 2KPYA 4KYPA 5CY0A 1ZYWA 5AQTA 1ATSA 3FZLA 4H5WA 2M8BB 5AQFA 1T0ZA 1T7BA 1I6GA 1NGCA 3FE1A 1BK8A 4H5VA 5AR0A 5AQOA 5AQYA 5F1XA 1SN4A 2JDQD 3D2FA 2QWRA 1UGLA 3KP1A 3KOZA 1BMRA 2YBRC 2LI7A 5AQUA 3SF4D 1NH5A 2E88A 2QWQA 1BUPA 1KAZA 1NGJA 1ATRA 2BRZA 5AQXA 1ZFUA 2MN5A 1GPTA 3L6QA 1BA0A 3KOWA 2LT8A 2E3GA 2LKBA 2NY9X 3C7NB 5AQZA 5AQJA 5BPMA 5AQSA 1POIA 5KK4A 2K35A 3ATUA 2KBKA 5AQIA 1C55A 2KGQA 1YUWA 2A7TA 1SN1A 1NPIA 3GL1A 3IUCA 5F0XA 2I61A 2LY5A 3KC6A 1JKZA 3GDQA 1DQ7A 1LQQA 1NGDA 1NGAA 1LQHA 3BK3C 5EVZA 2LY6A 2B3CA 2N66A 2QWOA 3A8YA 2GMOA 3FZMA 2SN3A 2MBKA 1DJTA 2QXLA 1CHZA 3KOYA 5FPMA 4AAZA 2LR3A 1FH3A 1T7EA 1NGGA 4H5RA 5BN9A 5AQPA 1XRSB 2KHOA 3KVGA 1ZYVA 3LDLA 1SEGA 1MYNA 1AYJA 3LDPA 3PSMA 1GPSA 1CN2A 1S3XA 3LDOA 2GL1A 2N2RA 1I2UA 1OZZA 2ASCA 3R2VA 1WT7A 2KYQA 3D2FB 1P0AA 4KBOA 5FPDA 3D2EA 5AQMA 1I2VA 1ZUTA 1MR4A 2LJMA 1NGFA 4H5NA 1JZBA 1NGEA 1B3CA 1P00A 1OMYA 1WMTA 2D56A 3KHWA 1JXCA 1AHOA 4AEIA 4FL9A 2YC1C 4H5TA 1QQOA 4UAEF 5EY4A 1DKGD 1NGHA 1L4VA 1NE5A 1LQIA 2E8AA 2QWNA 1JZAA 5F2RA 5AQVA 1NGIA 2VY6A 1VNBA 3LDQA 1HJOA 4V1DC 1NGBA 2MZ0A 2B68A 3QFUA 5FPEA 1T7AA 3E7UX 5AQKA 2QWPA 5AQQA 1SNBA 3QI7A 2YEOA 1I6FA 2YIPA 4HHFA 3FZHA 2KSKA 5AQLA 3AY9A 4HE7A 1QQNA 5AQNA 1KV0A 2V7ZA 2BUPA 3L56A 1QQMA 5BPNA 2KBJA 3I33A 3KP0A 2LN8A 2LJ7A 1KAYA 3C7NA 5EX5A 1NRAA 4HWIA 1TI5A 2QWMA 1B7DA 3JXUA 1NRBA 1BA1A 2N2QA 1PX9A 5AQRA 2NY8X 2E2FA 1T1TA 5AQHA 3LDNA 1N4NA 3ATVA 4IO8A 4UJ0A 1VNAA 3GKUA 1ZVEA 3QFPA 3FZFA 1ICAA
chains in the Genus database with same CATH topology
1WWNA 1BCGA 1PE4A 2KBHA 1ZU3A 2E3FA 4CQKA 4AB0A 3E7RL 1PTXA 2N69A 1C56A 2KJAA 1ZVGA 2ATBA 1BRZA 2E0HA 2KPYA 4KYPA 5CY0A 1ZYWA 1VNAA 2M8BB 1T0ZA 1T7BA 1I6GA 1BK8A 1SN4A 1BMRA 2YBRC 2LI7A 1NH5A 2BRZA 1ZFUA 1GPTA 2LT8A 2E3GA 2LKBA 2NY9X 5KK4A 1C55A 2KBKA 2KGQA 2A7TA 1SN1A 1NPIA 2I61A 2LY5A 1JKZA 1DQ7A 1LQQA 1LQHA 2LY6A 2B3CA 2N66A 2SN3A 1DJTA 1CHZA 4AAZA 2LR3A 1FH3A 1T7EA 1ZYVA 1SEGA 1MYNA 1AYJA 3PSMA 1GPSA 1CN2A 2GL1A 2N2RA 1I2UA 1OZZA 1WT7A 2KYQA 1P0AA 1I2VA 1ZUTA 1MR4A 2LJMA 1JZBA 1B3CA 1P00A 1OMYA 1WMTA 1JXCA 1AHOA 4AEIA 2YC1C 1L4VA 1NE5A 1LQIA 1JZAA 1VNBA 4V1DC 2MZ0A 2B68A 1T7AA 3E7UX 1SNBA 2YEOA 1I6FA 4HHFA 2KSKA 4HE7A 1KV0A 2KBJA 2LJ7A 1NRAA 1TI5A 1B7DA 1NRBA 2N2QA 1PX9A 2NY8X 1T1TA 1N4NA 4UJ0A 2ASCA 1ZVEA 1ICAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WWN A;  1BCG A;  1PE4 A;  2KBH A;  1ZU3 A;  2E3F A;  4CQK A;  4AB0 A;  3E7R L;  1PTX A;  2N69 A;  1C56 A;  2KJA A;  1ZVG A;  2ATB A;  1BRZ A;  2E0H A;  2KPY A;  4KYP A;  5CY0 A;  1ZYW A;  1VNA A;  2M8B B;  1T0Z A;  1T7B A;  1I6G A;  1BK8 A;  1SN4 A;  1BMR A;  2YBR C;  2LI7 A;  1NH5 A;  2BRZ A;  1ZFU A;  1GPT A;  2LT8 A;  2E3G A;  2LKB A;  2NY9 X;  5KK4 A;  1C55 A;  2KBK A;  2KGQ A;  2A7T A;  1SN1 A;  1NPI A;  2I61 A;  2LY5 A;  1JKZ A;  1DQ7 A;  1LQQ A;  1LQH A;  2LY6 A;  2B3C A;  2N66 A;  2SN3 A;  1DJT A;  1CHZ A;  4AAZ A;  2LR3 A;  1FH3 A;  1T7E A;  1ZYV A;  1SEG A;  1MYN A;  1AYJ A;  3PSM A;  1GPS A;  1CN2 A;  2GL1 A;  2N2R A;  1I2U A;  1OZZ A;  1WT7 A;  2KYQ A;  1P0A A;  1I2V A;  1ZUT A;  1MR4 A;  2LJM A;  1JZB A;  1B3C A;  1P00 A;  1OMY A;  1WMT A;  1JXC A;  1AHO A;  4AEI A;  2YC1 C;  1L4V A;  1NE5 A;  1LQI A;  1JZA A;  1VNB A;  4V1D C;  2MZ0 A;  2B68 A;  1T7A A;  3E7U X;  1SNB A;  2YEO A;  1I6F A;  4HHF A;  2KSK A;  4HE7 A;  1KV0 A;  2KBJ A;  2LJ7 A;  1NRA A;  1TI5 A;  1B7D A;  1NRB A;  2N2Q A;  1PX9 A;  2NY8 X;  1T1T A;  1N4N A;  4UJ0 A;  2ASC A;  1ZVE A;  1ICA A; 
#chains in the Genus database with same CATH topology
 1WWN A;  1BCG A;  1KAX A;  2QW9 A;  3M3Z A;  5AQG A;  1PE4 A;  5BN8 A;  2KBH A;  5AQW A;  3D2E B;  1ZU3 A;  3HSC A;  2E3F A;  3CW4 A;  1HX1 A;  5FPN A;  4CQK A;  4AB0 A;  3CQX A;  1PTX A;  2YIO A;  3E7R L;  4GNI A;  4FSV A;  5EXW A;  4UAF E;  2G2K A;  4UAD E;  3FZK A;  1HPM A;  2N69 A;  2QWL A;  5BPL A;  1C56 A;  2KJA A;  1ZVG A;  2ATB A;  3QML A;  1BRZ A;  2YIL A;  1K8B A;  3KOX A;  3L4I A;  2E0H A;  2KPY A;  4KYP A;  5CY0 A;  1ZYW A;  5AQT A;  1ATS A;  3FZL A;  4H5W A;  2M8B B;  5AQF A;  1T0Z A;  1T7B A;  1I6G A;  1NGC A;  3FE1 A;  1BK8 A;  4H5V A;  5AR0 A;  5AQO A;  5AQY A;  5F1X A;  1SN4 A;  2JDQ D;  3D2F A;  2QWR A;  1UGL A;  3KP1 A;  3KOZ A;  1BMR A;  2YBR C;  2LI7 A;  5AQU A;  3SF4 D;  1NH5 A;  2E88 A;  2QWQ A;  1BUP A;  1KAZ A;  1NGJ A;  1ATR A;  2BRZ A;  5AQX A;  1ZFU A;  2MN5 A;  1GPT A;  3L6Q A;  1BA0 A;  3KOW A;  2LT8 A;  2E3G A;  2LKB A;  2NY9 X;  3C7N B;  5AQZ A;  5AQJ A;  5BPM A;  5AQS A;  1POI A;  5KK4 A;  2K35 A;  3ATU A;  2KBK A;  5AQI A;  1C55 A;  2KGQ A;  1YUW A;  2A7T A;  1SN1 A;  1NPI A;  3GL1 A;  3IUC A;  5F0X A;  2I61 A;  2LY5 A;  3KC6 A;  1JKZ A;  3GDQ A;  1DQ7 A;  1LQQ A;  1NGD A;  1NGA A;  1LQH A;  3BK3 C;  5EVZ A;  2LY6 A;  2B3C A;  2N66 A;  2QWO A;  3A8Y A;  2GMO A;  3FZM A;  2SN3 A;  2MBK A;  1DJT A;  2QXL A;  1CHZ A;  3KOY A;  5FPM A;  4AAZ A;  2LR3 A;  1FH3 A;  1T7E A;  1NGG A;  4H5R A;  5BN9 A;  5AQP A;  1XRS B;  2KHO A;  3KVG A;  1ZYV A;  3LDL A;  1SEG A;  1MYN A;  1AYJ A;  3LDP A;  3PSM A;  1GPS A;  1CN2 A;  1S3X A;  3LDO A;  2GL1 A;  2N2R A;  1I2U A;  1OZZ A;  2ASC A;  3R2V A;  1WT7 A;  2KYQ A;  3D2F B;  1P0A A;  4KBO A;  5FPD A;  3D2E A;  5AQM A;  1I2V A;  1ZUT A;  1MR4 A;  2LJM A;  1NGF A;  4H5N A;  1JZB A;  1NGE A;  1B3C A;  1P00 A;  1OMY A;  1WMT A;  2D56 A;  3KHW A;  1JXC A;  1AHO A;  4AEI A;  4FL9 A;  2YC1 C;  4H5T A;  1QQO A;  4UAE F;  5EY4 A;  1DKG D;  1NGH A;  1L4V A;  1NE5 A;  1LQI A;  2E8A A;  2QWN A;  1JZA A;  5F2R A;  5AQV A;  1NGI A;  2VY6 A;  1VNB A;  3LDQ A;  1HJO A;  4V1D C;  1NGB A;  2MZ0 A;  2B68 A;  3QFU A;  5FPE A;  1T7A A;  3E7U X;  5AQK A;  2QWP A;  5AQQ A;  1SNB A;  3QI7 A;  2YEO A;  1I6F A;  2YIP A;  4HHF A;  3FZH A;  2KSK A;  5AQL A;  3AY9 A;  4HE7 A;  1QQN A;  5AQN A;  1KV0 A;  2V7Z A;  2BUP A;  3L56 A;  1QQM A;  5BPN A;  2KBJ A;  3I33 A;  3KP0 A;  2LN8 A;  2LJ7 A;  1KAY A;  3C7N A;  5EX5 A;  1NRA A;  4HWI A;  1TI5 A;  2QWM A;  1B7D A;  3JXU A;  1NRB A;  1BA1 A;  2N2Q A;  1PX9 A;  5AQR A;  2NY8 X;  2E2F A;  1T1T A;  5AQH A;  3LDN A;  1N4N A;  3ATV A;  4IO8 A;  4UJ0 A;  1VNA A;  3GKU A;  1ZVE A;  3QFP A;  3FZF A;  1ICA A; 
#chains in the Genus database with same CATH homology
 1WWN A;  1BCG A;  1PE4 A;  2KBH A;  1ZU3 A;  2E3F A;  4CQK A;  4AB0 A;  3E7R L;  1PTX A;  2N69 A;  1C56 A;  2KJA A;  1ZVG A;  2ATB A;  1BRZ A;  2E0H A;  2KPY A;  4KYP A;  5CY0 A;  1ZYW A;  1VNA A;  2M8B B;  1T0Z A;  1T7B A;  1I6G A;  1BK8 A;  1SN4 A;  1BMR A;  2YBR C;  2LI7 A;  1NH5 A;  2BRZ A;  1ZFU A;  1GPT A;  2LT8 A;  2E3G A;  2LKB A;  2NY9 X;  5KK4 A;  1C55 A;  2KBK A;  2KGQ A;  2A7T A;  1SN1 A;  1NPI A;  2I61 A;  2LY5 A;  1JKZ A;  1DQ7 A;  1LQQ A;  1LQH A;  2LY6 A;  2B3C A;  2N66 A;  2SN3 A;  1DJT A;  1CHZ A;  4AAZ A;  2LR3 A;  1FH3 A;  1T7E A;  1ZYV A;  1SEG A;  1MYN A;  1AYJ A;  3PSM A;  1GPS A;  1CN2 A;  2GL1 A;  2N2R A;  1I2U A;  1OZZ A;  1WT7 A;  2KYQ A;  1P0A A;  1I2V A;  1ZUT A;  1MR4 A;  2LJM A;  1JZB A;  1B3C A;  1P00 A;  1OMY A;  1WMT A;  1JXC A;  1AHO A;  4AEI A;  2YC1 C;  1L4V A;  1NE5 A;  1LQI A;  1JZA A;  1VNB A;  4V1D C;  2MZ0 A;  2B68 A;  1T7A A;  3E7U X;  1SNB A;  2YEO A;  1I6F A;  4HHF A;  2KSK A;  4HE7 A;  1KV0 A;  2KBJ A;  2LJ7 A;  1NRA A;  1TI5 A;  1B7D A;  1NRB A;  2N2Q A;  1PX9 A;  2NY8 X;  1T1T A;  1N4N A;  4UJ0 A;  2ASC A;  1ZVE A;  1ICA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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