2LKBA

Evolutionary diversification of mesobuthus alpha-scorpion toxins affecting sodium channels
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
66
structure length
66
Chain Sequence
ARDAYIAKPHNCVYECFDAFSSYCNGVCTKNGAKSGYCQILGTYGNGCWCIALPDNVPIRIPGKCH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Evolutionary diversification of Mesobuthus {alpha}-scorpion toxins affecting sodium channels
pubmed doi rcsb
molecule tags Toxin
molecule keywords Neurotoxin MeuNaTx-5
total genus 9
structure length 66
sequence length 66
ec nomenclature
pdb deposition date 2011-10-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00537 Toxin_3 Scorpion toxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.30.10 Alpha Beta 2-Layer Sandwich Defensin A-like Knottin, scorpion toxin-like 2lkbA00
1SN4A 2B68A 2BRZA 1DJTA 2LJMA 1GPSA 2N2RA 1T7AA 1VNAA 2KBHA 1MR4A 1P0AA 3E7RL 1T7BA 2KGQA 1JZAA 1L4VA 1JXCA 1SEGA 1JKZA 1LQHA 1WMTA 1LQIA 1ZVEA 1AYJA 1WT7A 2SN3A 4HE7A 1ZUTA 1GPTA 1CN2A 1I2VA 1NRBA 2LI7A 1VNBA 2KJAA 2KBJA 1N4NA 1I2UA 1TI5A 2B3CA 1CHZA 1NE5A 2LR3A 2YC1C 2NY9X 2A7TA 2E3GA 2N69A 1BMRA 1MYNA 2N66A 5CY0A 1T7EA 1NPIA 1SN1A 4AAZA 1PX9A 1P00A 4V1DC 3PSMA 1B7DA 1I6FA 2LY5A 2ASCA 1KV0A 1OZZA 2I61A 2LT8A 1ZFUA 1OMYA 1ZVGA 2YBRC 4HHFA 1ZU3A 2KSKA 2KYQA 1NH5A 1JZBA 4KYPA 1T0ZA 2LKBA 2LJ7A 1C55A 1NRAA 2E0HA 2M8BB 1WWNA 1DQ7A 1BRZA 4CQKA 1C56A 2NY8X 2GL1A 2KPYA 5KK4A 1PE4A 2MZ0A 1FH3A 1SNBA 2E3FA 1BCGA 2YEOA 4UJ0A 1ZYVA 4AB0A 1PTXA 1I6GA 3E7UX 1ICAA 1LQQA 1T1TA 1ZYWA 2LY6A 1BK8A 1AHOA 2N2QA 2KBKA 2ATBA 4AEIA 1B3CA
chains in the Genus database with same CATH superfamily
3FZFA 5AQNA 1SN4A 2B68A 2VY6A 2BRZA 2MBKA 3D2EB 1DJTA 2LJMA 1GPSA 2N2RA 1T7AA 1VNAA 2ATBA 2KBHA 3C7NB 3KOXA 5AQUA 3SF4D 5FPNA 3AY9A 1UGLA 4UAFE 5AQLA 2E2FA 1MR4A 3QMLA 1P0AA 5AQRA 3E7RL 3FZLA 3KOWA 5BPMA 1T7BA 3L6QA 3QI7A 1NGFA 2QWLA 2KGQA 1JZAA 5AQQA 1L4VA 1JXCA 1SEGA 3LDQA 3KVGA 1JKZA 1LQHA 1S3XA 5BPLA 2MN5A 4FL9A 1NGCA 3LDPA 1NGDA 1WMTA 1LQIA 1NGJA 1ZVEA 3ATUA 1QQOA 1WT7A 1AYJA 3KC6A 2QWMA 2G2KA 2SN3A 3KP0A 4HE7A 3GDQA 1ZUTA 2YIPA 1GPTA 1CN2A 1KAYA 3QFUA 1I2VA 1NRBA 1HX1A 1VNBA 2LI7A 2KJAA 2GMOA 5AQMA 2KBJA 1N4NA 5AQOA 1I2UA 1TI5A 2QWQA 5EVZA 3CQXA 3L56A 2B3CA 5EXWA 3D2FB 1CHZA 2QWNA 1NE5A 3KOZA 1NGAA 2LR3A 3BK3C 2YC1C 2NY9X 2A7TA 1NGGA 2E3GA 2N69A 2YIOA 3L4IA 3R2VA 4H5VA 1BMRA 1MYNA 3KHWA 4UAEF 2N66A 1POIA 3IUCA 5AQIA 5CY0A 3LDLA 1T7EA 1NPIA 1SN1A 4AAZA 5F0XA 3CW4A 1PX9A 2QWOA 2QWPA 1HPMA 4UADE 1P00A 3HSCA 5AQFA 4V1DC 1NGIA 3PSMA 1B7DA 1BA0A 1I6FA 2LY5A 1KAXA 3D2EA 3FZMA 2ASCA 1KV0A 5BPNA 3C7NA 5AQVA 1OZZA 1BUPA 2I61A 1ZFUA 2LT8A 1HJOA 1OMYA 5FPEA 1NGBA 1ZVGA 2V7ZA 4H5NA 5AQYA 2LN8A 1K8BA 2K35A 2YBRC 5F2RA 3QFPA 2YILA 4HHFA 1ZU3A 2D56A 1DKGD 1ATRA 1QQNA 2KSKA 2KYQA 2QW9A 5AQTA 1NH5A 5AR0A 5F1XA 1JZBA 4KYPA 1T0ZA 2LKBA 5AQZA 2LJ7A 5EX5A 2KHOA 1C55A 3LDOA 4H5TA 5AQXA 2QXLA 1YUWA 1NRAA 5AQKA 2E0HA 5AQGA 5FPMA 2JDQD 3A8YA 4H5WA 4GNIA 2M8BB 4KBOA 5AQHA 1WWNA 1DQ7A 2E88A 5AQJA 3GL1A 4IO8A 1KAZA 3I33A 1BRZA 4CQKA 3FZKA 1C56A 2E8AA 5FPDA 1QQMA 4HWIA 2NY8X 2GL1A 1NGEA 2KPYA 5KK4A 1PE4A 2MZ0A 5BN8A 1FH3A 3LDNA 1SNBA 2E3FA 1BCGA 5BN9A 4H5RA 1NGHA 3JXUA 1ATSA 2YEOA 4FSVA 4UJ0A 3D2FA 1ZYVA 3KOYA 3M3ZA 4AB0A 3FE1A 3ATVA 1PTXA 3GKUA 1I6GA 5AQPA 5AQWA 2QWRA 3E7UX 2BUPA 1ICAA 1LQQA 1T1TA 1ZYWA 2LY6A 3FZHA 5AQSA 1BK8A 1AHOA 3KP1A 2N2QA 2KBKA 1BA1A 5EY4A 1XRSB 4AEIA 1B3CA
chains in the Genus database with same CATH topology
1SN4A 2B68A 2BRZA 1DJTA 2LJMA 1GPSA 2N2RA 1T7AA 1VNAA 2KBHA 1MR4A 1P0AA 3E7RL 1T7BA 2KGQA 1JZAA 1L4VA 1JXCA 1SEGA 1JKZA 1LQHA 1WMTA 1LQIA 1ZVEA 1AYJA 1WT7A 2SN3A 4HE7A 1ZUTA 1GPTA 1CN2A 1I2VA 1NRBA 2LI7A 1VNBA 2KJAA 2KBJA 1N4NA 1I2UA 1TI5A 2B3CA 1CHZA 1NE5A 2LR3A 2YC1C 2NY9X 2A7TA 2E3GA 2N69A 1BMRA 1MYNA 2N66A 5CY0A 1T7EA 1NPIA 1SN1A 4AAZA 1PX9A 1P00A 4V1DC 3PSMA 1B7DA 1I6FA 2LY5A 2ASCA 1KV0A 1OZZA 2I61A 2LT8A 1ZFUA 1OMYA 1ZVGA 2YBRC 4HHFA 1ZU3A 2KSKA 2KYQA 1NH5A 1JZBA 4KYPA 1T0ZA 2LKBA 2LJ7A 1C55A 1NRAA 2E0HA 2M8BB 1WWNA 1DQ7A 1BRZA 4CQKA 1C56A 2NY8X 2GL1A 2KPYA 5KK4A 1PE4A 2MZ0A 1FH3A 1SNBA 2E3FA 1BCGA 2YEOA 4UJ0A 1ZYVA 4AB0A 1PTXA 1I6GA 3E7UX 1ICAA 1LQQA 1T1TA 1ZYWA 2LY6A 1BK8A 1AHOA 2N2QA 2KBKA 2ATBA 4AEIA 1B3CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SN4 A;  2B68 A;  2BRZ A;  1DJT A;  2LJM A;  1GPS A;  2N2R A;  1T7A A;  1VNA A;  2KBH A;  1MR4 A;  1P0A A;  3E7R L;  1T7B A;  2KGQ A;  1JZA A;  1L4V A;  1JXC A;  1SEG A;  1JKZ A;  1LQH A;  1WMT A;  1LQI A;  1ZVE A;  1AYJ A;  1WT7 A;  2SN3 A;  4HE7 A;  1ZUT A;  1GPT A;  1CN2 A;  1I2V A;  1NRB A;  2LI7 A;  1VNB A;  2KJA A;  2KBJ A;  1N4N A;  1I2U A;  1TI5 A;  2B3C A;  1CHZ A;  1NE5 A;  2LR3 A;  2YC1 C;  2NY9 X;  2A7T A;  2E3G A;  2N69 A;  1BMR A;  1MYN A;  2N66 A;  5CY0 A;  1T7E A;  1NPI A;  1SN1 A;  4AAZ A;  1PX9 A;  1P00 A;  4V1D C;  3PSM A;  1B7D A;  1I6F A;  2LY5 A;  2ASC A;  1KV0 A;  1OZZ A;  2I61 A;  2LT8 A;  1ZFU A;  1OMY A;  1ZVG A;  2YBR C;  4HHF A;  1ZU3 A;  2KSK A;  2KYQ A;  1NH5 A;  1JZB A;  4KYP A;  1T0Z A;  2LKB A;  2LJ7 A;  1C55 A;  1NRA A;  2E0H A;  2M8B B;  1WWN A;  1DQ7 A;  1BRZ A;  4CQK A;  1C56 A;  2NY8 X;  2GL1 A;  2KPY A;  5KK4 A;  1PE4 A;  2MZ0 A;  1FH3 A;  1SNB A;  2E3F A;  1BCG A;  2YEO A;  4UJ0 A;  1ZYV A;  4AB0 A;  1PTX A;  1I6G A;  3E7U X;  1ICA A;  1LQQ A;  1T1T A;  1ZYW A;  2LY6 A;  1BK8 A;  1AHO A;  2N2Q A;  2KBK A;  2ATB A;  4AEI A;  1B3C A; 
#chains in the Genus database with same CATH topology
 3FZF A;  5AQN A;  1SN4 A;  2B68 A;  2VY6 A;  2BRZ A;  2MBK A;  3D2E B;  1DJT A;  2LJM A;  1GPS A;  2N2R A;  1T7A A;  1VNA A;  2ATB A;  2KBH A;  3C7N B;  3KOX A;  5AQU A;  3SF4 D;  5FPN A;  3AY9 A;  1UGL A;  4UAF E;  5AQL A;  2E2F A;  1MR4 A;  3QML A;  1P0A A;  5AQR A;  3E7R L;  3FZL A;  3KOW A;  5BPM A;  1T7B A;  3L6Q A;  3QI7 A;  1NGF A;  2QWL A;  2KGQ A;  1JZA A;  5AQQ A;  1L4V A;  1JXC A;  1SEG A;  3LDQ A;  3KVG A;  1JKZ A;  1LQH A;  1S3X A;  5BPL A;  2MN5 A;  4FL9 A;  1NGC A;  3LDP A;  1NGD A;  1WMT A;  1LQI A;  1NGJ A;  1ZVE A;  3ATU A;  1QQO A;  1WT7 A;  1AYJ A;  3KC6 A;  2QWM A;  2G2K A;  2SN3 A;  3KP0 A;  4HE7 A;  3GDQ A;  1ZUT A;  2YIP A;  1GPT A;  1CN2 A;  1KAY A;  3QFU A;  1I2V A;  1NRB A;  1HX1 A;  1VNB A;  2LI7 A;  2KJA A;  2GMO A;  5AQM A;  2KBJ A;  1N4N A;  5AQO A;  1I2U A;  1TI5 A;  2QWQ A;  5EVZ A;  3CQX A;  3L56 A;  2B3C A;  5EXW A;  3D2F B;  1CHZ A;  2QWN A;  1NE5 A;  3KOZ A;  1NGA A;  2LR3 A;  3BK3 C;  2YC1 C;  2NY9 X;  2A7T A;  1NGG A;  2E3G A;  2N69 A;  2YIO A;  3L4I A;  3R2V A;  4H5V A;  1BMR A;  1MYN A;  3KHW A;  4UAE F;  2N66 A;  1POI A;  3IUC A;  5AQI A;  5CY0 A;  3LDL A;  1T7E A;  1NPI A;  1SN1 A;  4AAZ A;  5F0X A;  3CW4 A;  1PX9 A;  2QWO A;  2QWP A;  1HPM A;  4UAD E;  1P00 A;  3HSC A;  5AQF A;  4V1D C;  1NGI A;  3PSM A;  1B7D A;  1BA0 A;  1I6F A;  2LY5 A;  1KAX A;  3D2E A;  3FZM A;  2ASC A;  1KV0 A;  5BPN A;  3C7N A;  5AQV A;  1OZZ A;  1BUP A;  2I61 A;  1ZFU A;  2LT8 A;  1HJO A;  1OMY A;  5FPE A;  1NGB A;  1ZVG A;  2V7Z A;  4H5N A;  5AQY A;  2LN8 A;  1K8B A;  2K35 A;  2YBR C;  5F2R A;  3QFP A;  2YIL A;  4HHF A;  1ZU3 A;  2D56 A;  1DKG D;  1ATR A;  1QQN A;  2KSK A;  2KYQ A;  2QW9 A;  5AQT A;  1NH5 A;  5AR0 A;  5F1X A;  1JZB A;  4KYP A;  1T0Z A;  2LKB A;  5AQZ A;  2LJ7 A;  5EX5 A;  2KHO A;  1C55 A;  3LDO A;  4H5T A;  5AQX A;  2QXL A;  1YUW A;  1NRA A;  5AQK A;  2E0H A;  5AQG A;  5FPM A;  2JDQ D;  3A8Y A;  4H5W A;  4GNI A;  2M8B B;  4KBO A;  5AQH A;  1WWN A;  1DQ7 A;  2E88 A;  5AQJ A;  3GL1 A;  4IO8 A;  1KAZ A;  3I33 A;  1BRZ A;  4CQK A;  3FZK A;  1C56 A;  2E8A A;  5FPD A;  1QQM A;  4HWI A;  2NY8 X;  2GL1 A;  1NGE A;  2KPY A;  5KK4 A;  1PE4 A;  2MZ0 A;  5BN8 A;  1FH3 A;  3LDN A;  1SNB A;  2E3F A;  1BCG A;  5BN9 A;  4H5R A;  1NGH A;  3JXU A;  1ATS A;  2YEO A;  4FSV A;  4UJ0 A;  3D2F A;  1ZYV A;  3KOY A;  3M3Z A;  4AB0 A;  3FE1 A;  3ATV A;  1PTX A;  3GKU A;  1I6G A;  5AQP A;  5AQW A;  2QWR A;  3E7U X;  2BUP A;  1ICA A;  1LQQ A;  1T1T A;  1ZYW A;  2LY6 A;  3FZH A;  5AQS A;  1BK8 A;  1AHO A;  3KP1 A;  2N2Q A;  2KBK A;  1BA1 A;  5EY4 A;  1XRS B;  4AEI A;  1B3C A; 
#chains in the Genus database with same CATH homology
 1SN4 A;  2B68 A;  2BRZ A;  1DJT A;  2LJM A;  1GPS A;  2N2R A;  1T7A A;  1VNA A;  2KBH A;  1MR4 A;  1P0A A;  3E7R L;  1T7B A;  2KGQ A;  1JZA A;  1L4V A;  1JXC A;  1SEG A;  1JKZ A;  1LQH A;  1WMT A;  1LQI A;  1ZVE A;  1AYJ A;  1WT7 A;  2SN3 A;  4HE7 A;  1ZUT A;  1GPT A;  1CN2 A;  1I2V A;  1NRB A;  2LI7 A;  1VNB A;  2KJA A;  2KBJ A;  1N4N A;  1I2U A;  1TI5 A;  2B3C A;  1CHZ A;  1NE5 A;  2LR3 A;  2YC1 C;  2NY9 X;  2A7T A;  2E3G A;  2N69 A;  1BMR A;  1MYN A;  2N66 A;  5CY0 A;  1T7E A;  1NPI A;  1SN1 A;  4AAZ A;  1PX9 A;  1P00 A;  4V1D C;  3PSM A;  1B7D A;  1I6F A;  2LY5 A;  2ASC A;  1KV0 A;  1OZZ A;  2I61 A;  2LT8 A;  1ZFU A;  1OMY A;  1ZVG A;  2YBR C;  4HHF A;  1ZU3 A;  2KSK A;  2KYQ A;  1NH5 A;  1JZB A;  4KYP A;  1T0Z A;  2LKB A;  2LJ7 A;  1C55 A;  1NRA A;  2E0H A;  2M8B B;  1WWN A;  1DQ7 A;  1BRZ A;  4CQK A;  1C56 A;  2NY8 X;  2GL1 A;  2KPY A;  5KK4 A;  1PE4 A;  2MZ0 A;  1FH3 A;  1SNB A;  2E3F A;  1BCG A;  2YEO A;  4UJ0 A;  1ZYV A;  4AB0 A;  1PTX A;  1I6G A;  3E7U X;  1ICA A;  1LQQ A;  1T1T A;  1ZYW A;  2LY6 A;  1BK8 A;  1AHO A;  2N2Q A;  2KBK A;  2ATB A;  4AEI A;  1B3C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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