2YEOA

A39l mutation of scorpion toxin lqh-alpha-it
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
65
structure length
65
Chain Sequence
MVRDAYIAKNYNCVYECFRDAYCNELCTKNGASSGYCQWLGKYGNACWCYALPDNVPIRVPGKCR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of Scorpion Alpha-Toxinsmutants Reveal Conformational Constraints that Dictate Preference for Mammalian Brain Voltage-Gated Na- Channels
rcsb
molecule tags Toxin
source organism Leiurus quinquestriatus hebraeus
molecule keywords ALPHA-INSECT TOXIN LQHAIT
total genus 15
structure length 65
sequence length 65
ec nomenclature
pdb deposition date 2011-03-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00537 Toxin_3 Scorpion toxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.30.10 Alpha Beta 2-Layer Sandwich Defensin A-like Knottin, scorpion toxin-like 2yeoA00
2ASCA 1JKZA 1TI5A 1SN1A 1T1TA 1DJTA 1BRZA 1T7AA 1B7DA 1CHZA 1B3CA 2LKBA 1BMRA 3E7RL 2ATBA 1MYNA 1P0AA 2KSKA 5KK4A 4HHFA 1I2UA 5CY0A 2LR3A 2E3GA 2E0HA 1OZZA 1I6GA 1PE4A 4UJ0A 1JZBA 2YBRC 1SEGA 1L4VA 2N2RA 1ZVGA 2KGQA 1CN2A 1ZFUA 1T7EA 2LT8A 1KV0A 2M8BB 4V1DC 3PSMA 1MR4A 1SN4A 2KPYA 2NY9X 4HE7A 1WT7A 2SN3A 1ZVEA 1PTXA 1ZYWA 4CQKA 1VNAA 1NE5A 1T7BA 1I6FA 4AB0A 2E3FA 2KJAA 1VNBA 2BRZA 1C56A 1WWNA 1I2VA 1P00A 1ICAA 1LQQA 2B3CA 1OMYA 1BK8A 2LY6A 1AHOA 2A7TA 2B68A 2I61A 1LQHA 1DQ7A 4AEIA 1BCGA 1AYJA 1NPIA 1N4NA 1PX9A 2NY8X 1ZYVA 1NH5A 2KYQA 2LJMA 1C55A 1LQIA 2KBJA 1NRAA 2LJ7A 2N2QA 1SNBA 2KBKA 1GPSA 3E7UX 2LI7A 1WMTA 1JZAA 2MZ0A 2LY5A 2N69A 2KBHA 2YEOA 4AAZA 1ZUTA 2N66A 2YC1C 1T0ZA 1JXCA 1ZU3A 1NRBA 1FH3A 2GL1A 1GPTA 4KYPA
chains in the Genus database with same CATH superfamily
2ASCA 3LDLA 3QFPA 3CQXA 1JKZA 2QWOA 1TI5A 5BPMA 3KOXA 1NGJA 1SN1A 1T1TA 1DJTA 1BRZA 5AQHA 1T7AA 1NGCA 1B7DA 3GL1A 1CHZA 3C7NA 5AQLA 2E2FA 5AQOA 3I33A 1B3CA 3SF4D 1NGDA 2LKBA 1ATSA 1HPMA 1ATRA 5EX5A 4GNIA 1NGHA 5FPMA 1BMRA 5AQYA 4FSVA 3HSCA 1QQMA 4FL9A 1NGIA 1NGBA 3E7RL 1KAZA 4H5WA 3IUCA 3GKUA 2ATBA 5BPNA 1MYNA 1P0AA 4UADE 2KSKA 3D2EB 5AQSA 5AQPA 4KYPA 5BN9A 5KK4A 2QWPA 4H5NA 4HHFA 1I2UA 5CY0A 2LR3A 4H5TA 2E3GA 5AQZA 3BK3C 2E0HA 3KC6A 1OZZA 1I6GA 1PE4A 2QWNA 4UJ0A 5FPDA 1JZBA 3LDNA 1NGAA 2YBRC 1C55A 1SEGA 1L4VA 3GDQA 2N2RA 3AY9A 3D2FB 1KAXA 3CW4A 5AR0A 1ZVGA 5EXWA 1HX1A 2YILA 2KGQA 1CN2A 1ZFUA 2KHOA 1HJOA 5AQRA 1T7EA 2BUPA 2LT8A 1KV0A 4H5RA 5AQJA 2M8BB 2E8AA 4V1DC 3ATUA 5AQNA 5AQTA 3PSMA 4H5VA 1MR4A 2YIOA 3LDPA 2LN8A 1SN4A 2KPYA 2NY9X 1BA1A 1WT7A 4HE7A 5AQGA 2SN3A 1ZVEA 3FE1A 3C7NB 1PTXA 1ZYWA 4CQKA 1VNAA 1NE5A 1T7BA 1I6FA 4AB0A 2E3FA 4UAEF 2KJAA 4HWIA 2QWQA 1KAYA 1VNBA 2BRZA 1C56A 1WWNA 1I2VA 1P00A 1ICAA 2QXLA 2VY6A 1LQQA 3D2EA 2B3CA 1OMYA 1BK8A 4UAFE 4KBOA 3LDQA 2LY6A 5AQWA 3R2VA 1AHOA 3L56A 2A7TA 3L4IA 2JDQD 3FZKA 3KOWA 3KOZA 2B68A 2D56A 1POIA 2I61A 1S3XA 5AQXA 1LQHA 1DQ7A 5AQMA 2E88A 3KP1A 3JXUA 4AEIA 1XRSB 1BCGA 3KOYA 5FPEA 1AYJA 1NPIA 1N4NA 5F2RA 1PX9A 2NY8X 3QFUA 3L6QA 5AQUA 1ZYVA 1NH5A 2KYQA 2LJMA 3M3ZA 5F0XA 2MN5A 5BPLA 1LQIA 1QQNA 2KBJA 1NRAA 3QMLA 2LJ7A 4IO8A 5FPNA 2N2QA 1UGLA 2MBKA 1NGFA 1SNBA 2QWMA 3LDOA 2KBKA 1NGGA 3FZFA 3KHWA 5AQQA 3E7UX 5AQKA 5AQIA 1GPSA 2LI7A 1WMTA 5EY4A 1JZAA 2QWRA 3KP0A 2MZ0A 5AQFA 2QW9A 3A8YA 3FZMA 2LY5A 2N69A 2G2KA 3ATVA 2KBHA 2YIPA 2YEOA 5EVZA 5BN8A 2K35A 1BUPA 2V7ZA 4AAZA 1ZUTA 1DKGD 2N66A 2YC1C 3KVGA 1T0ZA 5F1XA 1NGEA 2GMOA 1JXCA 2QWLA 1BA0A 1ZU3A 3FZHA 3D2FA 5AQVA 1YUWA 1NRBA 1QQOA 3FZLA 1FH3A 2GL1A 1GPTA 1K8BA 3QI7A
chains in the Genus database with same CATH topology
2ASCA 1JKZA 1TI5A 1SN1A 1T1TA 1DJTA 1BRZA 1T7AA 1B7DA 1CHZA 1B3CA 2LKBA 1BMRA 3E7RL 2ATBA 1MYNA 1P0AA 2KSKA 5KK4A 4HHFA 1I2UA 5CY0A 2LR3A 2E3GA 2E0HA 1OZZA 1I6GA 1PE4A 4UJ0A 1JZBA 2YBRC 1SEGA 1L4VA 2N2RA 1ZVGA 2KGQA 1CN2A 1ZFUA 1T7EA 2LT8A 1KV0A 2M8BB 4V1DC 3PSMA 1MR4A 1SN4A 2KPYA 2NY9X 4HE7A 1WT7A 2SN3A 1ZVEA 1PTXA 1ZYWA 4CQKA 1VNAA 1NE5A 1T7BA 1I6FA 4AB0A 2E3FA 2KJAA 1VNBA 2BRZA 1C56A 1WWNA 1I2VA 1P00A 1ICAA 1LQQA 2B3CA 1OMYA 1BK8A 2LY6A 1AHOA 2A7TA 2B68A 2I61A 1LQHA 1DQ7A 4AEIA 1BCGA 1AYJA 1NPIA 1N4NA 1PX9A 2NY8X 1ZYVA 1NH5A 2KYQA 2LJMA 1C55A 1LQIA 2KBJA 1NRAA 2LJ7A 2N2QA 1SNBA 2KBKA 1GPSA 3E7UX 2LI7A 1WMTA 1JZAA 2MZ0A 2LY5A 2N69A 2KBHA 2YEOA 4AAZA 1ZUTA 2N66A 2YC1C 1T0ZA 1JXCA 1ZU3A 1NRBA 1FH3A 2GL1A 1GPTA 4KYPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ASC A;  1JKZ A;  1TI5 A;  1SN1 A;  1T1T A;  1DJT A;  1BRZ A;  1T7A A;  1B7D A;  1CHZ A;  1B3C A;  2LKB A;  1BMR A;  3E7R L;  2ATB A;  1MYN A;  1P0A A;  2KSK A;  5KK4 A;  4HHF A;  1I2U A;  5CY0 A;  2LR3 A;  2E3G A;  2E0H A;  1OZZ A;  1I6G A;  1PE4 A;  4UJ0 A;  1JZB A;  2YBR C;  1SEG A;  1L4V A;  2N2R A;  1ZVG A;  2KGQ A;  1CN2 A;  1ZFU A;  1T7E A;  2LT8 A;  1KV0 A;  2M8B B;  4V1D C;  3PSM A;  1MR4 A;  1SN4 A;  2KPY A;  2NY9 X;  4HE7 A;  1WT7 A;  2SN3 A;  1ZVE A;  1PTX A;  1ZYW A;  4CQK A;  1VNA A;  1NE5 A;  1T7B A;  1I6F A;  4AB0 A;  2E3F A;  2KJA A;  1VNB A;  2BRZ A;  1C56 A;  1WWN A;  1I2V A;  1P00 A;  1ICA A;  1LQQ A;  2B3C A;  1OMY A;  1BK8 A;  2LY6 A;  1AHO A;  2A7T A;  2B68 A;  2I61 A;  1LQH A;  1DQ7 A;  4AEI A;  1BCG A;  1AYJ A;  1NPI A;  1N4N A;  1PX9 A;  2NY8 X;  1ZYV A;  1NH5 A;  2KYQ A;  2LJM A;  1C55 A;  1LQI A;  2KBJ A;  1NRA A;  2LJ7 A;  2N2Q A;  1SNB A;  2KBK A;  1GPS A;  3E7U X;  2LI7 A;  1WMT A;  1JZA A;  2MZ0 A;  2LY5 A;  2N69 A;  2KBH A;  2YEO A;  4AAZ A;  1ZUT A;  2N66 A;  2YC1 C;  1T0Z A;  1JXC A;  1ZU3 A;  1NRB A;  1FH3 A;  2GL1 A;  1GPT A;  4KYP A; 
#chains in the Genus database with same CATH topology
 2ASC A;  3LDL A;  3QFP A;  3CQX A;  1JKZ A;  2QWO A;  1TI5 A;  5BPM A;  3KOX A;  1NGJ A;  1SN1 A;  1T1T A;  1DJT A;  1BRZ A;  5AQH A;  1T7A A;  1NGC A;  1B7D A;  3GL1 A;  1CHZ A;  3C7N A;  5AQL A;  2E2F A;  5AQO A;  3I33 A;  1B3C A;  3SF4 D;  1NGD A;  2LKB A;  1ATS A;  1HPM A;  1ATR A;  5EX5 A;  4GNI A;  1NGH A;  5FPM A;  1BMR A;  5AQY A;  4FSV A;  3HSC A;  1QQM A;  4FL9 A;  1NGI A;  1NGB A;  3E7R L;  1KAZ A;  4H5W A;  3IUC A;  3GKU A;  2ATB A;  5BPN A;  1MYN A;  1P0A A;  4UAD E;  2KSK A;  3D2E B;  5AQS A;  5AQP A;  4KYP A;  5BN9 A;  5KK4 A;  2QWP A;  4H5N A;  4HHF A;  1I2U A;  5CY0 A;  2LR3 A;  4H5T A;  2E3G A;  5AQZ A;  3BK3 C;  2E0H A;  3KC6 A;  1OZZ A;  1I6G A;  1PE4 A;  2QWN A;  4UJ0 A;  5FPD A;  1JZB A;  3LDN A;  1NGA A;  2YBR C;  1C55 A;  1SEG A;  1L4V A;  3GDQ A;  2N2R A;  3AY9 A;  3D2F B;  1KAX A;  3CW4 A;  5AR0 A;  1ZVG A;  5EXW A;  1HX1 A;  2YIL A;  2KGQ A;  1CN2 A;  1ZFU A;  2KHO A;  1HJO A;  5AQR A;  1T7E A;  2BUP A;  2LT8 A;  1KV0 A;  4H5R A;  5AQJ A;  2M8B B;  2E8A A;  4V1D C;  3ATU A;  5AQN A;  5AQT A;  3PSM A;  4H5V A;  1MR4 A;  2YIO A;  3LDP A;  2LN8 A;  1SN4 A;  2KPY A;  2NY9 X;  1BA1 A;  1WT7 A;  4HE7 A;  5AQG A;  2SN3 A;  1ZVE A;  3FE1 A;  3C7N B;  1PTX A;  1ZYW A;  4CQK A;  1VNA A;  1NE5 A;  1T7B A;  1I6F A;  4AB0 A;  2E3F A;  4UAE F;  2KJA A;  4HWI A;  2QWQ A;  1KAY A;  1VNB A;  2BRZ A;  1C56 A;  1WWN A;  1I2V A;  1P00 A;  1ICA A;  2QXL A;  2VY6 A;  1LQQ A;  3D2E A;  2B3C A;  1OMY A;  1BK8 A;  4UAF E;  4KBO A;  3LDQ A;  2LY6 A;  5AQW A;  3R2V A;  1AHO A;  3L56 A;  2A7T A;  3L4I A;  2JDQ D;  3FZK A;  3KOW A;  3KOZ A;  2B68 A;  2D56 A;  1POI A;  2I61 A;  1S3X A;  5AQX A;  1LQH A;  1DQ7 A;  5AQM A;  2E88 A;  3KP1 A;  3JXU A;  4AEI A;  1XRS B;  1BCG A;  3KOY A;  5FPE A;  1AYJ A;  1NPI A;  1N4N A;  5F2R A;  1PX9 A;  2NY8 X;  3QFU A;  3L6Q A;  5AQU A;  1ZYV A;  1NH5 A;  2KYQ A;  2LJM A;  3M3Z A;  5F0X A;  2MN5 A;  5BPL A;  1LQI A;  1QQN A;  2KBJ A;  1NRA A;  3QML A;  2LJ7 A;  4IO8 A;  5FPN A;  2N2Q A;  1UGL A;  2MBK A;  1NGF A;  1SNB A;  2QWM A;  3LDO A;  2KBK A;  1NGG A;  3FZF A;  3KHW A;  5AQQ A;  3E7U X;  5AQK A;  5AQI A;  1GPS A;  2LI7 A;  1WMT A;  5EY4 A;  1JZA A;  2QWR A;  3KP0 A;  2MZ0 A;  5AQF A;  2QW9 A;  3A8Y A;  3FZM A;  2LY5 A;  2N69 A;  2G2K A;  3ATV A;  2KBH A;  2YIP A;  2YEO A;  5EVZ A;  5BN8 A;  2K35 A;  1BUP A;  2V7Z A;  4AAZ A;  1ZUT A;  1DKG D;  2N66 A;  2YC1 C;  3KVG A;  1T0Z A;  5F1X A;  1NGE A;  2GMO A;  1JXC A;  2QWL A;  1BA0 A;  1ZU3 A;  3FZH A;  3D2F A;  5AQV A;  1YUW A;  1NRB A;  1QQO A;  3FZL A;  1FH3 A;  2GL1 A;  1GPT A;  1K8B A;  3QI7 A; 
#chains in the Genus database with same CATH homology
 2ASC A;  1JKZ A;  1TI5 A;  1SN1 A;  1T1T A;  1DJT A;  1BRZ A;  1T7A A;  1B7D A;  1CHZ A;  1B3C A;  2LKB A;  1BMR A;  3E7R L;  2ATB A;  1MYN A;  1P0A A;  2KSK A;  5KK4 A;  4HHF A;  1I2U A;  5CY0 A;  2LR3 A;  2E3G A;  2E0H A;  1OZZ A;  1I6G A;  1PE4 A;  4UJ0 A;  1JZB A;  2YBR C;  1SEG A;  1L4V A;  2N2R A;  1ZVG A;  2KGQ A;  1CN2 A;  1ZFU A;  1T7E A;  2LT8 A;  1KV0 A;  2M8B B;  4V1D C;  3PSM A;  1MR4 A;  1SN4 A;  2KPY A;  2NY9 X;  4HE7 A;  1WT7 A;  2SN3 A;  1ZVE A;  1PTX A;  1ZYW A;  4CQK A;  1VNA A;  1NE5 A;  1T7B A;  1I6F A;  4AB0 A;  2E3F A;  2KJA A;  1VNB A;  2BRZ A;  1C56 A;  1WWN A;  1I2V A;  1P00 A;  1ICA A;  1LQQ A;  2B3C A;  1OMY A;  1BK8 A;  2LY6 A;  1AHO A;  2A7T A;  2B68 A;  2I61 A;  1LQH A;  1DQ7 A;  4AEI A;  1BCG A;  1AYJ A;  1NPI A;  1N4N A;  1PX9 A;  2NY8 X;  1ZYV A;  1NH5 A;  2KYQ A;  2LJM A;  1C55 A;  1LQI A;  2KBJ A;  1NRA A;  2LJ7 A;  2N2Q A;  1SNB A;  2KBK A;  1GPS A;  3E7U X;  2LI7 A;  1WMT A;  1JZA A;  2MZ0 A;  2LY5 A;  2N69 A;  2KBH A;  2YEO A;  4AAZ A;  1ZUT A;  2N66 A;  2YC1 C;  1T0Z A;  1JXC A;  1ZU3 A;  1NRB A;  1FH3 A;  2GL1 A;  1GPT A;  4KYP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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