2YEOA

A39l mutation of scorpion toxin lqh-alpha-it
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
65
structure length
65
Chain Sequence
MVRDAYIAKNYNCVYECFRDAYCNELCTKNGASSGYCQWLGKYGNACWCYALPDNVPIRVPGKCR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of Scorpion Alpha-Toxinsmutants Reveal Conformational Constraints that Dictate Preference for Mammalian Brain Voltage-Gated Na- Channels
rcsb
molecule tags Toxin
source organism Leiurus quinquestriatus hebraeus
molecule keywords ALPHA-INSECT TOXIN LQHAIT
total genus 15
structure length 65
sequence length 65
ec nomenclature
pdb deposition date 2011-03-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00537 Toxin_3 Scorpion toxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.30.10 Alpha Beta 2-Layer Sandwich Defensin A-like Knottin, scorpion toxin-like 2yeoA00
2LI7A 2KBHA 2N2QA 2B68A 2NY8X 1B3CA 1MR4A 1MYNA 1L4VA 3PSMA 1ZFUA 1NH5A 4AB0A 1BMRA 4CQKA 2N2RA 2ASCA 1JKZA 1NE5A 2LY6A 1LQQA 1AYJA 2NY9X 1VNBA 2BRZA 1B7DA 1ZYWA 1C55A 2I61A 2LT8A 3E7RL 2GL1A 1FH3A 2YBRC 2E0HA 1VNAA 2KGQA 1KV0A 1P0AA 2LKBA 1I6FA 1BRZA 1ZVGA 4V1DC 1NPIA 1WT7A 1JZAA 1WWNA 1DJTA 1TI5A 1JZBA 1SEGA 2LJMA 2KJAA 4HHFA 4AEIA 1P00A 1ZVEA 1WMTA 2LR3A 1NRBA 2KSKA 2N69A 2LY5A 2MZ0A 2KYQA 1CHZA 1PTXA 2ATBA 2E3GA 1OZZA 2LJ7A 2B3CA 1NRAA 1N4NA 1LQHA 5CY0A 2KPYA 1ICAA 2SN3A 1C56A 2YEOA 1SN1A 2KBJA 1CN2A 1GPSA 1SN4A 1OMYA 1T7AA 1JXCA 1I2VA 2KBKA 1SNBA 1ZU3A 2A7TA 4UJ0A 3E7UX 1ZUTA 1GPTA 1ZYVA 1LQIA 1PE4A 2M8BB 1T1TA 4KYPA 1AHOA 5KK4A 1BCGA 1PX9A 4AAZA 1T7BA 2YC1C 1I6GA 1DQ7A 1I2UA 2E3FA 2N66A 1T7EA 1BK8A 1T0ZA 4HE7A
chains in the Genus database with same CATH superfamily
5AQWA 3C7NB 3HSCA 3A8YA 2LI7A 5EXWA 2KBHA 2MN5A 2N2QA 2B68A 5FPMA 2NY8X 1B3CA 1MR4A 1BA0A 1MYNA 1L4VA 4H5NA 3PSMA 3D2EB 1HJOA 1ZFUA 2QWLA 1NH5A 3ATUA 1POIA 3IUCA 3KC6A 5AQMA 4AB0A 3KOXA 2N2RA 3L6QA 4CQKA 5AQSA 1BMRA 2ASCA 1JKZA 1NE5A 2LY6A 3GL1A 5BPNA 1LQQA 1NGDA 1AYJA 2NY9X 5AQKA 5AQXA 5FPEA 1QQNA 1GPSA 1VNBA 5AQIA 5BPMA 3CW4A 4FSVA 2BRZA 5AQPA 2QWPA 1B7DA 1ZYWA 1C55A 3BK3C 1QQMA 2I61A 3CQXA 2YILA 3FZHA 3FZLA 2LT8A 3E7RL 3KOWA 5AQHA 2GL1A 2VY6A 1NGBA 1XRSB 4FL9A 1FH3A 2YBRC 5BPLA 3QI7A 2E0HA 2QWOA 1VNAA 3GDQA 3LDNA 2KGQA 5AQQA 1KV0A 1P0AA 2LKBA 1I6FA 5AR0A 1NGAA 5AQYA 5AQUA 1ZVGA 3KHWA 4V1DC 5EX5A 1BRZA 1NGGA 1NPIA 1WT7A 5AQTA 2K35A 1JZAA 3LDLA 2QWRA 3D2FB 1WWNA 3M3ZA 5AQOA 1DJTA 3KVGA 1TI5A 1JZBA 1SEGA 2LJMA 3KP1A 1KAYA 2KJAA 1HPMA 3FZFA 5AQFA 4HHFA 4AEIA 1P00A 4KBOA 2QWMA 1UGLA 1ZVEA 2YIPA 1WMTA 2LR3A 1NRBA 4H5WA 3C7NA 1NGIA 5AQLA 4GNIA 4IO8A 2KSKA 2N69A 2LY5A 3L4IA 2MZ0A 4UAEF 3KP0A 2KYQA 2KHOA 3LDPA 2JDQD 3FE1A 1CHZA 1PTXA 3FZKA 3QFPA 2V7ZA 2ATBA 1BA1A 1ATSA 1HX1A 2E3GA 3D2EA 4UADE 1OZZA 3LDQA 3R2VA 2LJ7A 1NGCA 2B3CA 1NGJA 1NRAA 3FZMA 1N4NA 4HWIA 3SF4D 1LQHA 5CY0A 1NGEA 2KPYA 1ICAA 1NGFA 5AQRA 2SN3A 1C56A 1KAXA 1SN1A 2KBJA 2YEOA 1S3XA 5AQGA 1SN4A 1CN2A 1YUWA 2GMOA 1QQOA 1OMYA 1T7AA 5AQNA 5EY4A 1JXCA 2E88A 5F0XA 5FPDA 1I2VA 2KBKA 1SNBA 4H5RA 1K8BA 5BN8A 1ZU3A 2A7TA 1ATRA 2QWQA 3AY9A 3KOZA 4UJ0A 3E7UX 2QXLA 1ZUTA 5EVZA 1GPTA 1ZYVA 4H5TA 1LQIA 1PE4A 1KAZA 2M8BB 1T1TA 3I33A 4KYPA 1NGHA 5AQVA 3GKUA 5FPNA 2QW9A 2YIOA 3ATVA 2G2KA 3QFUA 5AQZA 5F2RA 1AHOA 5KK4A 2LN8A 1BCGA 1PX9A 2BUPA 2QWNA 2MBKA 3LDOA 4AAZA 1DKGD 3L56A 5BN9A 1T7BA 2YC1C 3D2FA 3QMLA 2E2FA 4UAFE 1I6GA 4H5VA 1DQ7A 1I2UA 2E8AA 2E3FA 2N66A 1T7EA 3KOYA 5AQJA 1BK8A 1T0ZA 5F1XA 1BUPA 2D56A 3JXUA 4HE7A
chains in the Genus database with same CATH topology
2LI7A 2KBHA 2N2QA 2B68A 2NY8X 1B3CA 1MR4A 1MYNA 1L4VA 3PSMA 1ZFUA 1NH5A 4AB0A 1BMRA 4CQKA 2N2RA 2ASCA 1JKZA 1NE5A 2LY6A 1LQQA 1AYJA 2NY9X 1VNBA 2BRZA 1B7DA 1ZYWA 1C55A 2I61A 2LT8A 3E7RL 2GL1A 1FH3A 2YBRC 2E0HA 1VNAA 2KGQA 1KV0A 1P0AA 2LKBA 1I6FA 1BRZA 1ZVGA 4V1DC 1NPIA 1WT7A 1JZAA 1WWNA 1DJTA 1TI5A 1JZBA 1SEGA 2LJMA 2KJAA 4HHFA 4AEIA 1P00A 1ZVEA 1WMTA 2LR3A 1NRBA 2KSKA 2N69A 2LY5A 2MZ0A 2KYQA 1CHZA 1PTXA 2ATBA 2E3GA 1OZZA 2LJ7A 2B3CA 1NRAA 1N4NA 1LQHA 5CY0A 2KPYA 1ICAA 2SN3A 1C56A 2YEOA 1SN1A 2KBJA 1CN2A 1GPSA 1SN4A 1OMYA 1T7AA 1JXCA 1I2VA 2KBKA 1SNBA 1ZU3A 2A7TA 4UJ0A 3E7UX 1ZUTA 1GPTA 1ZYVA 1LQIA 1PE4A 2M8BB 1T1TA 4KYPA 1AHOA 5KK4A 1BCGA 1PX9A 4AAZA 1T7BA 2YC1C 1I6GA 1DQ7A 1I2UA 2E3FA 2N66A 1T7EA 1BK8A 1T0ZA 4HE7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2LI7 A;  2KBH A;  2N2Q A;  2B68 A;  2NY8 X;  1B3C A;  1MR4 A;  1MYN A;  1L4V A;  3PSM A;  1ZFU A;  1NH5 A;  4AB0 A;  1BMR A;  4CQK A;  2N2R A;  2ASC A;  1JKZ A;  1NE5 A;  2LY6 A;  1LQQ A;  1AYJ A;  2NY9 X;  1VNB A;  2BRZ A;  1B7D A;  1ZYW A;  1C55 A;  2I61 A;  2LT8 A;  3E7R L;  2GL1 A;  1FH3 A;  2YBR C;  2E0H A;  1VNA A;  2KGQ A;  1KV0 A;  1P0A A;  2LKB A;  1I6F A;  1BRZ A;  1ZVG A;  4V1D C;  1NPI A;  1WT7 A;  1JZA A;  1WWN A;  1DJT A;  1TI5 A;  1JZB A;  1SEG A;  2LJM A;  2KJA A;  4HHF A;  4AEI A;  1P00 A;  1ZVE A;  1WMT A;  2LR3 A;  1NRB A;  2KSK A;  2N69 A;  2LY5 A;  2MZ0 A;  2KYQ A;  1CHZ A;  1PTX A;  2ATB A;  2E3G A;  1OZZ A;  2LJ7 A;  2B3C A;  1NRA A;  1N4N A;  1LQH A;  5CY0 A;  2KPY A;  1ICA A;  2SN3 A;  1C56 A;  2YEO A;  1SN1 A;  2KBJ A;  1CN2 A;  1GPS A;  1SN4 A;  1OMY A;  1T7A A;  1JXC A;  1I2V A;  2KBK A;  1SNB A;  1ZU3 A;  2A7T A;  4UJ0 A;  3E7U X;  1ZUT A;  1GPT A;  1ZYV A;  1LQI A;  1PE4 A;  2M8B B;  1T1T A;  4KYP A;  1AHO A;  5KK4 A;  1BCG A;  1PX9 A;  4AAZ A;  1T7B A;  2YC1 C;  1I6G A;  1DQ7 A;  1I2U A;  2E3F A;  2N66 A;  1T7E A;  1BK8 A;  1T0Z A;  4HE7 A; 
#chains in the Genus database with same CATH topology
 5AQW A;  3C7N B;  3HSC A;  3A8Y A;  2LI7 A;  5EXW A;  2KBH A;  2MN5 A;  2N2Q A;  2B68 A;  5FPM A;  2NY8 X;  1B3C A;  1MR4 A;  1BA0 A;  1MYN A;  1L4V A;  4H5N A;  3PSM A;  3D2E B;  1HJO A;  1ZFU A;  2QWL A;  1NH5 A;  3ATU A;  1POI A;  3IUC A;  3KC6 A;  5AQM A;  4AB0 A;  3KOX A;  2N2R A;  3L6Q A;  4CQK A;  5AQS A;  1BMR A;  2ASC A;  1JKZ A;  1NE5 A;  2LY6 A;  3GL1 A;  5BPN A;  1LQQ A;  1NGD A;  1AYJ A;  2NY9 X;  5AQK A;  5AQX A;  5FPE A;  1QQN A;  1GPS A;  1VNB A;  5AQI A;  5BPM A;  3CW4 A;  4FSV A;  2BRZ A;  5AQP A;  2QWP A;  1B7D A;  1ZYW A;  1C55 A;  3BK3 C;  1QQM A;  2I61 A;  3CQX A;  2YIL A;  3FZH A;  3FZL A;  2LT8 A;  3E7R L;  3KOW A;  5AQH A;  2GL1 A;  2VY6 A;  1NGB A;  1XRS B;  4FL9 A;  1FH3 A;  2YBR C;  5BPL A;  3QI7 A;  2E0H A;  2QWO A;  1VNA A;  3GDQ A;  3LDN A;  2KGQ A;  5AQQ A;  1KV0 A;  1P0A A;  2LKB A;  1I6F A;  5AR0 A;  1NGA A;  5AQY A;  5AQU A;  1ZVG A;  3KHW A;  4V1D C;  5EX5 A;  1BRZ A;  1NGG A;  1NPI A;  1WT7 A;  5AQT A;  2K35 A;  1JZA A;  3LDL A;  2QWR A;  3D2F B;  1WWN A;  3M3Z A;  5AQO A;  1DJT A;  3KVG A;  1TI5 A;  1JZB A;  1SEG A;  2LJM A;  3KP1 A;  1KAY A;  2KJA A;  1HPM A;  3FZF A;  5AQF A;  4HHF A;  4AEI A;  1P00 A;  4KBO A;  2QWM A;  1UGL A;  1ZVE A;  2YIP A;  1WMT A;  2LR3 A;  1NRB A;  4H5W A;  3C7N A;  1NGI A;  5AQL A;  4GNI A;  4IO8 A;  2KSK A;  2N69 A;  2LY5 A;  3L4I A;  2MZ0 A;  4UAE F;  3KP0 A;  2KYQ A;  2KHO A;  3LDP A;  2JDQ D;  3FE1 A;  1CHZ A;  1PTX A;  3FZK A;  3QFP A;  2V7Z A;  2ATB A;  1BA1 A;  1ATS A;  1HX1 A;  2E3G A;  3D2E A;  4UAD E;  1OZZ A;  3LDQ A;  3R2V A;  2LJ7 A;  1NGC A;  2B3C A;  1NGJ A;  1NRA A;  3FZM A;  1N4N A;  4HWI A;  3SF4 D;  1LQH A;  5CY0 A;  1NGE A;  2KPY A;  1ICA A;  1NGF A;  5AQR A;  2SN3 A;  1C56 A;  1KAX A;  1SN1 A;  2KBJ A;  2YEO A;  1S3X A;  5AQG A;  1SN4 A;  1CN2 A;  1YUW A;  2GMO A;  1QQO A;  1OMY A;  1T7A A;  5AQN A;  5EY4 A;  1JXC A;  2E88 A;  5F0X A;  5FPD A;  1I2V A;  2KBK A;  1SNB A;  4H5R A;  1K8B A;  5BN8 A;  1ZU3 A;  2A7T A;  1ATR A;  2QWQ A;  3AY9 A;  3KOZ A;  4UJ0 A;  3E7U X;  2QXL A;  1ZUT A;  5EVZ A;  1GPT A;  1ZYV A;  4H5T A;  1LQI A;  1PE4 A;  1KAZ A;  2M8B B;  1T1T A;  3I33 A;  4KYP A;  1NGH A;  5AQV A;  3GKU A;  5FPN A;  2QW9 A;  2YIO A;  3ATV A;  2G2K A;  3QFU A;  5AQZ A;  5F2R A;  1AHO A;  5KK4 A;  2LN8 A;  1BCG A;  1PX9 A;  2BUP A;  2QWN A;  2MBK A;  3LDO A;  4AAZ A;  1DKG D;  3L56 A;  5BN9 A;  1T7B A;  2YC1 C;  3D2F A;  3QML A;  2E2F A;  4UAF E;  1I6G A;  4H5V A;  1DQ7 A;  1I2U A;  2E8A A;  2E3F A;  2N66 A;  1T7E A;  3KOY A;  5AQJ A;  1BK8 A;  1T0Z A;  5F1X A;  1BUP A;  2D56 A;  3JXU A;  4HE7 A; 
#chains in the Genus database with same CATH homology
 2LI7 A;  2KBH A;  2N2Q A;  2B68 A;  2NY8 X;  1B3C A;  1MR4 A;  1MYN A;  1L4V A;  3PSM A;  1ZFU A;  1NH5 A;  4AB0 A;  1BMR A;  4CQK A;  2N2R A;  2ASC A;  1JKZ A;  1NE5 A;  2LY6 A;  1LQQ A;  1AYJ A;  2NY9 X;  1VNB A;  2BRZ A;  1B7D A;  1ZYW A;  1C55 A;  2I61 A;  2LT8 A;  3E7R L;  2GL1 A;  1FH3 A;  2YBR C;  2E0H A;  1VNA A;  2KGQ A;  1KV0 A;  1P0A A;  2LKB A;  1I6F A;  1BRZ A;  1ZVG A;  4V1D C;  1NPI A;  1WT7 A;  1JZA A;  1WWN A;  1DJT A;  1TI5 A;  1JZB A;  1SEG A;  2LJM A;  2KJA A;  4HHF A;  4AEI A;  1P00 A;  1ZVE A;  1WMT A;  2LR3 A;  1NRB A;  2KSK A;  2N69 A;  2LY5 A;  2MZ0 A;  2KYQ A;  1CHZ A;  1PTX A;  2ATB A;  2E3G A;  1OZZ A;  2LJ7 A;  2B3C A;  1NRA A;  1N4N A;  1LQH A;  5CY0 A;  2KPY A;  1ICA A;  2SN3 A;  1C56 A;  2YEO A;  1SN1 A;  2KBJ A;  1CN2 A;  1GPS A;  1SN4 A;  1OMY A;  1T7A A;  1JXC A;  1I2V A;  2KBK A;  1SNB A;  1ZU3 A;  2A7T A;  4UJ0 A;  3E7U X;  1ZUT A;  1GPT A;  1ZYV A;  1LQI A;  1PE4 A;  2M8B B;  1T1T A;  4KYP A;  1AHO A;  5KK4 A;  1BCG A;  1PX9 A;  4AAZ A;  1T7B A;  2YC1 C;  1I6G A;  1DQ7 A;  1I2U A;  2E3F A;  2N66 A;  1T7E A;  1BK8 A;  1T0Z A;  4HE7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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