4JRAC

Crystal structure of the botulinum neurotoxin a receptor-binding domain in complex with the luminal domain of sv2c
Total Genus 20
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
85
structure length
83
Chain Sequence
ANFTITMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords Botulinum neurotoxin type A
total genus 20
structure length 83
sequence length 85
chains with identical sequence D
ec nomenclature
pdb deposition date 2013-03-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF13599 Pentapeptide_4 Pentapeptide repeats (9 copies)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.160.20.100 Mainly Beta 3 Solenoid Pectate Lyase C-like Pectate Lyase C-like 4jraC00
3N90A 2F3LA 4JRAC 2BM6A 2J8IA 2BM7A 2BM5A 5JLVC 2BM4A 2W7ZA 5JMCB 2G0YA
chains in the Genus database with same CATH superfamily
2O04A 2J8KA 1HG8A 4XLEA 4W8SA 1EA0A 1TYWA 3JX8A 3PSZA 3LMWA 1CZFA 3B4NA 3GRHA 3SZEA 1NHCA 2VBEA 1KQ5A 3EQOA 4YEIA 1O8KA 1LLWA 2NT6A 2XTXA 4XOTA 3EQNA 4NK6A 2X6YA 3B8YA 4XONA 3UW0A 4EW9A 2IQ7A 4YEJA 2NZMA 2NSTA 2X3HA 3ML3A 3WWGA 4XM3A 4AVZA 2B0RA 2O0VA 4XOPA 1IA5A 2VFOA 1HF2A 5JLVC 2EWEA 2O17A 1OOCA 4W8QA 1GQ8A 2VFNA 1DBOA 3JURA 1IB4A 1TYUA 3BH7B 4JRAC 1DBGA 4XLAA 4YDTA 1O8FA 4W8RA 4Z06A 3DU1X 2INUA 1WMRA 3FY3A 2XT4A 4XLFA 1DABA 2O6WA 3SYJA 3PETA 1XG2A 1RU4A 3VMVA 2XC1A 4HWVA 5DNSA 3SQVA 1QA2A 4XL9A 1O8GA 1BHEA 1O8MA 4OJLA 4Z05A 4OJOA 2G0YA 2PYHA 4XKVA 2BM6A 3LYCA 4YELA 4PMHA 3B90A 3GQAA 3GQ8A 1OGOX 3P4GA 5JMCB 2X6WA 1O8EA 3LJYA 2VFPA 4XR6A 3RIQA 1BN8A 3ZSCA 4YZ0A 4OJ5A 4OM9A 1QA3A 3GQ7A 1O8JA 2QYUA 4U49A 2NSPA 2QY1A 1LM1A 4XNFA 1CLWA 2QZAA 3NB2A 1O8HA 4URRA 1OGMX 1QRCA 4MXNA 2V5IA 3AK5A 1K8FA 1QQ1A 1X0CA 1OFMA 3GQ9A 4Z03A 3T9GA 2UVFA 2INVA 2PYGA 2VFQA 1EZGA 4YZQA 3VSUA 1AIRA 3SY2A 4XLHA 2W7ZA 4YZXA 1QRBA 3N6ZA 1RMGA 4XORA 3N90A 4YFOA 4YCQA 3VMWA 2BM5A 1O8DA 2BX6A 2ODLA 5C1CA 1L1IA 3NAWA 2NTPA 1EE6A 3PSSA 1OFDA 5C1EA 4OZZA 4V02C 2XTYA 1TSPA 2QX3A 2X6XA 4XKWA 2XT2A 2O0WA 2BM7A 4OPWA 4XN0A 4OJ6A 1VBLA 4W8TA 4XLCA 1KCDA 1TYVA 2VJJA 2YUHA 1QA1A 2NTQA 3TH0A 4XQFA 1O88A 1PLUA 1K4ZA 1IDJA 1KTWA 2J8IA 2VBMA 3KRGA 4XMYA 4YZAA 2BM4A 4U4BA 4C2LA 1WXRA 3ZPPA 4MR0A 2O1DA 1OFEA 4NK8A 1RWRA 4OJPA 1JTAA 2X85A 2VFMA 1OFLA 5AMVA 1QJVA 3VSVA 1O8LA 1PXZA 3H09A 1QCXA 2NTBA 1KCCA 1LLZA 1H80A 2XTWA 3BH6B 4I84A 3VSTA 2VBKA 1PE9A 4OZYA 2IOUG 1K5CA 2NT9A 1TYXA 2BSPA 2QXZA 2PECA 2VJIA 2UVEA 3SUCA 2F3LA 4XN3A 4KH3A 1IDKA 4YC5A 1O8IA 2Z8GA 1JRGA
chains in the Genus database with same CATH topology
3SYJA 3TH0A 3PETA 1K4ZA 2VFQA 2XC1A 2J8IA 1TYWA 3JX8A 1QA2A 3SZEA 2BM4A 2W7ZA 1WXRA 1QRBA 3N6ZA 4OJLA 1KQ5A 4OJOA 2G0YA 4OJPA 3N90A 2VFMA 2BM6A 3LYCA 2BM5A 2YUHA 1QA1A 2BX6A 3P4GA 5JMCB 3ML3A 3H09A 3LJYA 2VFPA 3RIQA 2B0RA 4OJ5A 4OM9A 1QA3A 3BH6B 2VFOA 1HF2A 4V02C 5JLVC 1TSPA 2IOUG 2VFNA 1TYXA 1CLWA 1TYUA 2F3LA 3BH7B 4JRAC 2BM7A 4OPWA 4KH3A 1QRCA 4OJ6A 2V5IA 3AK5A 1K8FA 1QQ1A 1TYVA 1DABA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3N90 A;  2F3L A;  4JRA C;  2BM6 A;  2J8I A;  2BM7 A;  2BM5 A;  5JLV C;  2BM4 A;  2W7Z A;  5JMC B;  2G0Y A; 
#chains in the Genus database with same CATH topology
 2O04 A;  2J8K A;  1HG8 A;  4XLE A;  4W8S A;  1EA0 A;  1TYW A;  3JX8 A;  3PSZ A;  3LMW A;  1CZF A;  3B4N A;  3GRH A;  3SZE A;  1NHC A;  2VBE A;  1KQ5 A;  3EQO A;  4YEI A;  1O8K A;  1LLW A;  2NT6 A;  2XTX A;  4XOT A;  3EQN A;  4NK6 A;  2X6Y A;  3B8Y A;  4XON A;  3UW0 A;  4EW9 A;  2IQ7 A;  4YEJ A;  2NZM A;  2NST A;  2X3H A;  3ML3 A;  3WWG A;  4XM3 A;  4AVZ A;  2B0R A;  2O0V A;  4XOP A;  1IA5 A;  2VFO A;  1HF2 A;  5JLV C;  2EWE A;  2O17 A;  1OOC A;  4W8Q A;  1GQ8 A;  2VFN A;  1DBO A;  3JUR A;  1IB4 A;  1TYU A;  3BH7 B;  4JRA C;  1DBG A;  4XLA A;  4YDT A;  1O8F A;  4W8R A;  4Z06 A;  3DU1 X;  2INU A;  1WMR A;  3FY3 A;  2XT4 A;  4XLF A;  1DAB A;  2O6W A;  3SYJ A;  3PET A;  1XG2 A;  1RU4 A;  3VMV A;  2XC1 A;  4HWV A;  5DNS A;  3SQV A;  1QA2 A;  4XL9 A;  1O8G A;  1BHE A;  1O8M A;  4OJL A;  4Z05 A;  4OJO A;  2G0Y A;  2PYH A;  4XKV A;  2BM6 A;  3LYC A;  4YEL A;  4PMH A;  3B90 A;  3GQA A;  3GQ8 A;  1OGO X;  3P4G A;  5JMC B;  2X6W A;  1O8E A;  3LJY A;  2VFP A;  4XR6 A;  3RIQ A;  1BN8 A;  3ZSC A;  4YZ0 A;  4OJ5 A;  4OM9 A;  1QA3 A;  3GQ7 A;  1O8J A;  2QYU A;  4U49 A;  2NSP A;  2QY1 A;  1LM1 A;  4XNF A;  1CLW A;  2QZA A;  3NB2 A;  1O8H A;  4URR A;  1OGM X;  1QRC A;  4MXN A;  2V5I A;  3AK5 A;  1K8F A;  1QQ1 A;  1X0C A;  1OFM A;  3GQ9 A;  4Z03 A;  3T9G A;  2UVF A;  2INV A;  2PYG A;  2VFQ A;  1EZG A;  4YZQ A;  3VSU A;  1AIR A;  3SY2 A;  4XLH A;  2W7Z A;  4YZX A;  1QRB A;  3N6Z A;  1RMG A;  4XOR A;  3N90 A;  4YFO A;  4YCQ A;  3VMW A;  2BM5 A;  1O8D A;  2BX6 A;  2ODL A;  5C1C A;  1L1I A;  3NAW A;  2NTP A;  1EE6 A;  3PSS A;  1OFD A;  5C1E A;  4OZZ A;  4V02 C;  2XTY A;  1TSP A;  2QX3 A;  2X6X A;  4XKW A;  2XT2 A;  2O0W A;  2BM7 A;  4OPW A;  4XN0 A;  4OJ6 A;  1VBL A;  4W8T A;  4XLC A;  1KCD A;  1TYV A;  2VJJ A;  2YUH A;  1QA1 A;  2NTQ A;  3TH0 A;  4XQF A;  1O88 A;  1PLU A;  1K4Z A;  1IDJ A;  1KTW A;  2J8I A;  2VBM A;  3KRG A;  4XMY A;  4YZA A;  2BM4 A;  4U4B A;  4C2L A;  1WXR A;  3ZPP A;  4MR0 A;  2O1D A;  1OFE A;  4NK8 A;  1RWR A;  4OJP A;  1JTA A;  2X85 A;  2VFM A;  1OFL A;  5AMV A;  1QJV A;  3VSV A;  1O8L A;  1PXZ A;  3H09 A;  1QCX A;  2NTB A;  1KCC A;  1LLZ A;  1H80 A;  2XTW A;  3BH6 B;  4I84 A;  3VST A;  2VBK A;  1PE9 A;  4OZY A;  2IOU G;  1K5C A;  2NT9 A;  1TYX A;  2BSP A;  2QXZ A;  2PEC A;  2VJI A;  2UVE A;  3SUC A;  2F3L A;  4XN3 A;  4KH3 A;  1IDK A;  4YC5 A;  1O8I A;  2Z8G A;  1JRG A; 
#chains in the Genus database with same CATH homology
 3SYJ A;  3TH0 A;  3PET A;  1K4Z A;  2VFQ A;  2XC1 A;  2J8I A;  1TYW A;  3JX8 A;  1QA2 A;  3SZE A;  2BM4 A;  2W7Z A;  1WXR A;  1QRB A;  3N6Z A;  4OJL A;  1KQ5 A;  4OJO A;  2G0Y A;  4OJP A;  3N90 A;  2VFM A;  2BM6 A;  3LYC A;  2BM5 A;  2YUH A;  1QA1 A;  2BX6 A;  3P4G A;  5JMC B;  3ML3 A;  3H09 A;  3LJY A;  2VFP A;  3RIQ A;  2B0R A;  4OJ5 A;  4OM9 A;  1QA3 A;  3BH6 B;  2VFO A;  1HF2 A;  4V02 C;  5JLV C;  1TSP A;  2IOU G;  2VFN A;  1TYX A;  1CLW A;  1TYU A;  2F3L A;  3BH7 B;  4JRA C;  2BM7 A;  4OPW A;  4KH3 A;  1QRC A;  4OJ6 A;  2V5I A;  3AK5 A;  1K8F A;  1QQ1 A;  1TYV A;  1DAB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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