1LR8A

Crystal structure of fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue d-myo-inositol hexasulphate (ins6s)
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
73
structure length
73
Chain Sequence
ETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGKCK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hormone/growth factor
source organism Rattus norvegicus
publication title Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
pubmed doi rcsb
molecule keywords Follistatin
total genus 13
structure length 73
sequence length 73
ec nomenclature
pdb deposition date 2002-05-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07648 Kazal_2 Kazal-type serine protease inhibitor domain
A PF09289 FOLN Follistatin/Osteonectin-like EGF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 1lr8A00
1TURA 2SGPI 1PJUA 1SGEI 2GKTI 3B4VC 2WCYA 2N17A 2KMQA 2GKRI 1KMAA 1SGDI 2V53A 1CT2I 2ARPF 1CSOI 2XRCA 1CT4I 3TJQA 1SGYI 2KCXA 1CE3A 5JHWC 1OMUA 1LR9A 1TBRR 2P6AC 1N13A 2N52A 1YU6C 5DAEA 2B0UC 2SGEI 1BUSA 1M8CA 2KMPA 1SGRI 1OVOA 1DS2I 1DS3I 2M5XA 1MT1A 2KMRA 1TUSA 1UVGA 1FYBA 2QQCA 1LR8A 1SGQI 1OYVI 3SGQI 2JYYA 2KMOA 1PPFI 2GKVA 2NU0I 2NU2I 1HDLA 2QQDA 1YTPA 2N71A 1TBQR 2F3CI 3OVOA 2OVOA 1CHOI 1LR7A 1PCEA 1R0RI 2LEOA 1H0ZA 3SEKC 4GI3C 1UVFA 3SGBI 1SGPI 1OMTA 2NU3I 2BUSA 2NU4I 1TIHA 1TGSI 2SGDI 1Y1CA 3QTLD 1AN1I 1Z7KB 4SGBI 1CT0I 1IW4A 1HPTA 1SGNI 1CGII 1CGJI 4OVOA 1Y1BA 3HH2C 2NU1I 1IY6A 2JXDA 2JZMA 1BMOA 1NUBA 1UUCA 1IY5A 1HJAI 2SGQI 4HGUA 2ERWA 2SGFI 1M8BA
chains in the Genus database with same CATH superfamily
1TURA 3UGIA 2FNFX 2L7XA 2ORWA 1PJUA 2SGPI 3R5BA 4JCVE 1SGEI 4E1PA 2YUUA 2RIJA 3KY9A 4UXJA 3TO6A 2GKTI 3B4VC 3TOAA 3R5CA 2WCYA 1K7UA 3UGLA 2N17A 2ENNA 2GKRI 1W3SA 2KMQA 2CWFA 3D00A 1KMAA 1SGDI 1V1IA 2PQ8A 2V53A 2N1AB 2WGCA 1K7VA 1FARA 1ULNA 2CJSC 2OU2A 2UVOA 3CXLA 5J8CA 1KBFA 3QWPA 3FSYA 5J8FA 1CT2I 2ARPF 3R5DA 5HQ8A 3UEJA 2Y0MA 1CSOI 4WP4A 1WKXA 2ENZA 2K9HA 2XRCA 1CT4I 3R5AA 5FUXA 3TJQA 2DKVA 3UEYA 1SGYI 2KCXA 1V1HA 1P9ZA 3OXGA 1CE3A 5FUVA 5JHWC 1XX6A 1OMUA 1LR9A 2W0TA 1MJBA 1MJ9A 1TBRR 1TOTA 1FY7A 1N13A 1NXUA 2N52A 1YU6C 2P6AC 5EX0A 3FC3A 5DAEA 2ROWA 2B0UC 2SGEI 1BUSA 1M8CA 1P9GA 1FAQA 2UZ3A 2KMPA 3FSXA 1SGRI 3VE5A 1OVOA 2JA1A 2E5RA 2X3TA 1DS2I 3MEKA 3VDUA 2QQEA 1UHAA 1DS3I 2CWGA 1MT1A 2M5XA 1PTQA 2QPOA 2QQ0A 2WVJA 1TBOA 2KMRA 1TUSA 1UVGA 3VDPA 1FYBA 1WGCA 3TO7A 2QQCA 1Y8FA 2J87A 4L9MA 1LR8A 5FUWA 1SGQI 2DB6A 1K7TA 1OYVI 2A20A 2E73A 2JYYA 2KMOA 2RC4A 4UXIA 3SGQI 1PPFI 2GKVA 2V1CC 5HI7A 2NU0I 2L8EA 5CCLA 3TO9A 2NU2I 1HDLA 3RU0A 1Z2IA 2QQDA 1YTPA 2LUYA 2CWHA 3OXFA 1PTRA 2N71A 2X52A 5E3PA 4DNCA 1TBQR 2J9RA 1KBEA 2F3CI 3OVOA 2OVOA 1WTJA 1CHOI 1LR7A 1PCEA 1R0RI 2LEOA 2ORVA 2OZUA 1Q9BA 1MJAA 3SEKC 1XBTA 1H0ZA 1X74A 1UVFA 4GI3C 3QAHA 3SGBI 1SGPI 3UFFA 2VRWB 5EX3A 1OMTA 4MPIA 1WGTA 2BUSA 2NU3I 2GVIA 2NU4I 5E3RA 5CCMA 4E1RA 1TIHA 1TGSI 3BJIA 2SGDI 2YQPA 1Y1CA 5E3QA 3QTLD 2B8TA 4B6DA 1AN1I 1Z7KB 1TBNA 4SGBI 3UOEA 1CT0I 3GOXA 2ODDA 2GIVA 2OD1A 4AMLA 1HPTA 4FKDA 1IW4A 1SGNI 2LB7A 5FUYA 1CGII 1U5KA 4UXHA 1CGJI 4OVOA 3TOBA 7WGAA 1HEVA 1Y1BA 1VDDA 2ELIA 4A24A 3E2IA 1ULMA 3HH2C 3UGDA 1S20A 2JW6A 2NU1I 3PDNA 1IY6A 2JXDA 1R79A 2JZMA 1BMOA 3OL0A 2V1CA 1NUBA 1UUCA 1ULKA 2DIPA 1RFHA 1XA6A 1IY5A 1HJAI 1X4SA 2SGQI 4HGUA 3OXLA 2ERWA 3E59A 1W4RA 9WGAA 2SGFI 1M8BA
chains in the Genus database with same CATH topology
1TURA 3UGIA 2FNFX 2L7XA 2ORWA 1PJUA 2SGPI 4JCVE 1SGEI 4E1PA 2YUUA 3KY9A 4UXJA 2GKTI 3B4VC 2WCYA 3UGLA 2N17A 2ENNA 2GKRI 1W3SA 2KMQA 1KMAA 3D00A 1SGDI 1V1IA 2V53A 2N1AB 2CJSC 1FARA 3CXLA 1KBFA 3QWPA 1CT2I 2ARPF 5HQ8A 3UEJA 1CSOI 2K9HA 2ENZA 2XRCA 5FUXA 1CT4I 3TJQA 3UEYA 1SGYI 2KCXA 1V1HA 3OXGA 1CE3A 5FUVA 5JHWC 1XX6A 1OMUA 1LR9A 2W0TA 1TOTA 1TBRR 2P6AC 1N13A 2N52A 3FC3A 1YU6C 5EX0A 5DAEA 2ROWA 2B0UC 2SGEI 1BUSA 1M8CA 1FAQA 2UZ3A 2KMPA 3VE5A 1SGRI 1OVOA 2JA1A 2E5RA 3MEKA 1DS2I 3VDUA 2QQEA 1DS3I 2M5XA 1MT1A 2QPOA 1PTQA 2QQ0A 2WVJA 1TBOA 2KMRA 1TUSA 1UVGA 3VDPA 1FYBA 2QQCA 1Y8FA 2J87A 4L9MA 1LR8A 5FUWA 1SGQI 2DB6A 2E73A 1OYVI 2A20A 2JYYA 3SGQI 2KMOA 4UXIA 1PPFI 2GKVA 2V1CC 5HI7A 2NU0I 2L8EA 5CCLA 2NU2I 1HDLA 3RU0A 2QQDA 1YTPA 2LUYA 3OXFA 1PTRA 2N71A 1TBQR 2J9RA 1KBEA 2F3CI 3OVOA 2OVOA 1CHOI 1LR7A 1PCEA 1R0RI 2LEOA 2ORVA 1H0ZA 3SEKC 1XBTA 1X74A 1UVFA 4GI3C 3SGBI 1SGPI 3UFFA 2VRWB 5EX3A 1OMTA 2NU3I 2BUSA 2GVIA 2NU4I 5CCMA 4E1RA 1TIHA 1TGSI 3BJIA 2SGDI 2YQPA 1Y1CA 4B6DA 3QTLD 2B8TA 3GOXA 1AN1I 1Z7KB 1TBNA 4SGBI 1CT0I 2ODDA 1IW4A 2OD1A 1HPTA 4FKDA 1SGNI 5FUYA 1CGII 1U5KA 4UXHA 1CGJI 4OVOA 1Y1BA 1VDDA 2ELIA 4A24A 3E2IA 3HH2C 3UGDA 2JW6A 2NU1I 3PDNA 1IY6A 2JXDA 1R79A 2JZMA 1BMOA 3OL0A 2V1CA 1NUBA 1UUCA 2DIPA 1RFHA 1XA6A 1IY5A 1HJAI 1X4SA 2SGQI 4HGUA 3OXLA 2ERWA 3E59A 1W4RA 2SGFI 1M8BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TUR A;  2SGP I;  1PJU A;  1SGE I;  2GKT I;  3B4V C;  2WCY A;  2N17 A;  2KMQ A;  2GKR I;  1KMA A;  1SGD I;  2V53 A;  1CT2 I;  2ARP F;  1CSO I;  2XRC A;  1CT4 I;  3TJQ A;  1SGY I;  2KCX A;  1CE3 A;  5JHW C;  1OMU A;  1LR9 A;  1TBR R;  2P6A C;  1N13 A;  2N52 A;  1YU6 C;  5DAE A;  2B0U C;  2SGE I;  1BUS A;  1M8C A;  2KMP A;  1SGR I;  1OVO A;  1DS2 I;  1DS3 I;  2M5X A;  1MT1 A;  2KMR A;  1TUS A;  1UVG A;  1FYB A;  2QQC A;  1LR8 A;  1SGQ I;  1OYV I;  3SGQ I;  2JYY A;  2KMO A;  1PPF I;  2GKV A;  2NU0 I;  2NU2 I;  1HDL A;  2QQD A;  1YTP A;  2N71 A;  1TBQ R;  2F3C I;  3OVO A;  2OVO A;  1CHO I;  1LR7 A;  1PCE A;  1R0R I;  2LEO A;  1H0Z A;  3SEK C;  4GI3 C;  1UVF A;  3SGB I;  1SGP I;  1OMT A;  2NU3 I;  2BUS A;  2NU4 I;  1TIH A;  1TGS I;  2SGD I;  1Y1C A;  3QTL D;  1AN1 I;  1Z7K B;  4SGB I;  1CT0 I;  1IW4 A;  1HPT A;  1SGN I;  1CGI I;  1CGJ I;  4OVO A;  1Y1B A;  3HH2 C;  2NU1 I;  1IY6 A;  2JXD A;  2JZM A;  1BMO A;  1NUB A;  1UUC A;  1IY5 A;  1HJA I;  2SGQ I;  4HGU A;  2ERW A;  2SGF I;  1M8B A; 
#chains in the Genus database with same CATH topology
 1TUR A;  3UGI A;  2FNF X;  2L7X A;  2ORW A;  1PJU A;  2SGP I;  3R5B A;  4JCV E;  1SGE I;  4E1P A;  2YUU A;  2RIJ A;  3KY9 A;  4UXJ A;  3TO6 A;  2GKT I;  3B4V C;  3TOA A;  3R5C A;  2WCY A;  1K7U A;  3UGL A;  2N17 A;  2ENN A;  2GKR I;  1W3S A;  2KMQ A;  2CWF A;  3D00 A;  1KMA A;  1SGD I;  1V1I A;  2PQ8 A;  2V53 A;  2N1A B;  2WGC A;  1K7V A;  1FAR A;  1ULN A;  2CJS C;  2OU2 A;  2UVO A;  3CXL A;  5J8C A;  1KBF A;  3QWP A;  3FSY A;  5J8F A;  1CT2 I;  2ARP F;  3R5D A;  5HQ8 A;  3UEJ A;  2Y0M A;  1CSO I;  4WP4 A;  1WKX A;  2ENZ A;  2K9H A;  2XRC A;  1CT4 I;  3R5A A;  5FUX A;  3TJQ A;  2DKV A;  3UEY A;  1SGY I;  2KCX A;  1V1H A;  1P9Z A;  3OXG A;  1CE3 A;  5FUV A;  5JHW C;  1XX6 A;  1OMU A;  1LR9 A;  2W0T A;  1MJB A;  1MJ9 A;  1TBR R;  1TOT A;  1FY7 A;  1N13 A;  1NXU A;  2N52 A;  1YU6 C;  2P6A C;  5EX0 A;  3FC3 A;  5DAE A;  2ROW A;  2B0U C;  2SGE I;  1BUS A;  1M8C A;  1P9G A;  1FAQ A;  2UZ3 A;  2KMP A;  3FSX A;  1SGR I;  3VE5 A;  1OVO A;  2JA1 A;  2E5R A;  2X3T A;  1DS2 I;  3MEK A;  3VDU A;  2QQE A;  1UHA A;  1DS3 I;  2CWG A;  1MT1 A;  2M5X A;  1PTQ A;  2QPO A;  2QQ0 A;  2WVJ A;  1TBO A;  2KMR A;  1TUS A;  1UVG A;  3VDP A;  1FYB A;  1WGC A;  3TO7 A;  2QQC A;  1Y8F A;  2J87 A;  4L9M A;  1LR8 A;  5FUW A;  1SGQ I;  2DB6 A;  1K7T A;  1OYV I;  2A20 A;  2E73 A;  2JYY A;  2KMO A;  2RC4 A;  4UXI A;  3SGQ I;  1PPF I;  2GKV A;  2V1C C;  5HI7 A;  2NU0 I;  2L8E A;  5CCL A;  3TO9 A;  2NU2 I;  1HDL A;  3RU0 A;  1Z2I A;  2QQD A;  1YTP A;  2LUY A;  2CWH A;  3OXF A;  1PTR A;  2N71 A;  2X52 A;  5E3P A;  4DNC A;  1TBQ R;  2J9R A;  1KBE A;  2F3C I;  3OVO A;  2OVO A;  1WTJ A;  1CHO I;  1LR7 A;  1PCE A;  1R0R I;  2LEO A;  2ORV A;  2OZU A;  1Q9B A;  1MJA A;  3SEK C;  1XBT A;  1H0Z A;  1X74 A;  1UVF A;  4GI3 C;  3QAH A;  3SGB I;  1SGP I;  3UFF A;  2VRW B;  5EX3 A;  1OMT A;  4MPI A;  1WGT A;  2BUS A;  2NU3 I;  2GVI A;  2NU4 I;  5E3R A;  5CCM A;  4E1R A;  1TIH A;  1TGS I;  3BJI A;  2SGD I;  2YQP A;  1Y1C A;  5E3Q A;  3QTL D;  2B8T A;  4B6D A;  1AN1 I;  1Z7K B;  1TBN A;  4SGB I;  3UOE A;  1CT0 I;  3GOX A;  2ODD A;  2GIV A;  2OD1 A;  4AML A;  1HPT A;  4FKD A;  1IW4 A;  1SGN I;  2LB7 A;  5FUY A;  1CGI I;  1U5K A;  4UXH A;  1CGJ I;  4OVO A;  3TOB A;  7WGA A;  1HEV A;  1Y1B A;  1VDD A;  2ELI A;  4A24 A;  3E2I A;  1ULM A;  3HH2 C;  3UGD A;  1S20 A;  2JW6 A;  2NU1 I;  3PDN A;  1IY6 A;  2JXD A;  1R79 A;  2JZM A;  1BMO A;  3OL0 A;  2V1C A;  1NUB A;  1UUC A;  1ULK A;  2DIP A;  1RFH A;  1XA6 A;  1IY5 A;  1HJA I;  1X4S A;  2SGQ I;  4HGU A;  3OXL A;  2ERW A;  3E59 A;  1W4R A;  9WGA A;  2SGF I;  1M8B A; 
#chains in the Genus database with same CATH homology
 1TUR A;  3UGI A;  2FNF X;  2L7X A;  2ORW A;  1PJU A;  2SGP I;  4JCV E;  1SGE I;  4E1P A;  2YUU A;  3KY9 A;  4UXJ A;  2GKT I;  3B4V C;  2WCY A;  3UGL A;  2N17 A;  2ENN A;  2GKR I;  1W3S A;  2KMQ A;  1KMA A;  3D00 A;  1SGD I;  1V1I A;  2V53 A;  2N1A B;  2CJS C;  1FAR A;  3CXL A;  1KBF A;  3QWP A;  1CT2 I;  2ARP F;  5HQ8 A;  3UEJ A;  1CSO I;  2K9H A;  2ENZ A;  2XRC A;  5FUX A;  1CT4 I;  3TJQ A;  3UEY A;  1SGY I;  2KCX A;  1V1H A;  3OXG A;  1CE3 A;  5FUV A;  5JHW C;  1XX6 A;  1OMU A;  1LR9 A;  2W0T A;  1TOT A;  1TBR R;  2P6A C;  1N13 A;  2N52 A;  3FC3 A;  1YU6 C;  5EX0 A;  5DAE A;  2ROW A;  2B0U C;  2SGE I;  1BUS A;  1M8C A;  1FAQ A;  2UZ3 A;  2KMP A;  3VE5 A;  1SGR I;  1OVO A;  2JA1 A;  2E5R A;  3MEK A;  1DS2 I;  3VDU A;  2QQE A;  1DS3 I;  2M5X A;  1MT1 A;  2QPO A;  1PTQ A;  2QQ0 A;  2WVJ A;  1TBO A;  2KMR A;  1TUS A;  1UVG A;  3VDP A;  1FYB A;  2QQC A;  1Y8F A;  2J87 A;  4L9M A;  1LR8 A;  5FUW A;  1SGQ I;  2DB6 A;  2E73 A;  1OYV I;  2A20 A;  2JYY A;  3SGQ I;  2KMO A;  4UXI A;  1PPF I;  2GKV A;  2V1C C;  5HI7 A;  2NU0 I;  2L8E A;  5CCL A;  2NU2 I;  1HDL A;  3RU0 A;  2QQD A;  1YTP A;  2LUY A;  3OXF A;  1PTR A;  2N71 A;  1TBQ R;  2J9R A;  1KBE A;  2F3C I;  3OVO A;  2OVO A;  1CHO I;  1LR7 A;  1PCE A;  1R0R I;  2LEO A;  2ORV A;  1H0Z A;  3SEK C;  1XBT A;  1X74 A;  1UVF A;  4GI3 C;  3SGB I;  1SGP I;  3UFF A;  2VRW B;  5EX3 A;  1OMT A;  2NU3 I;  2BUS A;  2GVI A;  2NU4 I;  5CCM A;  4E1R A;  1TIH A;  1TGS I;  3BJI A;  2SGD I;  2YQP A;  1Y1C A;  4B6D A;  3QTL D;  2B8T A;  3GOX A;  1AN1 I;  1Z7K B;  1TBN A;  4SGB I;  1CT0 I;  2ODD A;  1IW4 A;  2OD1 A;  1HPT A;  4FKD A;  1SGN I;  5FUY A;  1CGI I;  1U5K A;  4UXH A;  1CGJ I;  4OVO A;  1Y1B A;  1VDD A;  2ELI A;  4A24 A;  3E2I A;  3HH2 C;  3UGD A;  2JW6 A;  2NU1 I;  3PDN A;  1IY6 A;  2JXD A;  1R79 A;  2JZM A;  1BMO A;  3OL0 A;  2V1C A;  1NUB A;  1UUC A;  2DIP A;  1RFH A;  1XA6 A;  1IY5 A;  1HJA I;  1X4S A;  2SGQ I;  4HGU A;  3OXL A;  2ERW A;  3E59 A;  1W4R A;  2SGF I;  1M8B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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