1LR8A

Crystal structure of fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue d-myo-inositol hexasulphate (ins6s)
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
73
structure length
73
Chain Sequence
ETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGKCK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
pubmed doi rcsb
molecule tags Hormone/growth factor
source organism Rattus norvegicus
molecule keywords Follistatin
total genus 13
structure length 73
sequence length 73
ec nomenclature
pdb deposition date 2002-05-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07648 Kazal_2 Kazal-type serine protease inhibitor domain
A PF09289 FOLN Follistatin/Osteonectin-like EGF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 1lr8A00
2KMRA 2WCYA 2JZMA 1H0ZA 1CGII 4HGUA 1TURA 2JYYA 2GKTI 2SGQI 1TBQR 2N71A 2SGPI 2NU0I 2KMQA 1PCEA 1IY5A 1HPTA 2SGDI 1TGSI 3QTLD 1LR9A 1R0RI 2KMPA 1PJUA 1UVGA 2XRCA 1Y1BA 3HH2C 1CT2I 3SGQI 3SGBI 1BMOA 1SGEI 1PPFI 3TJQA 1FYBA 2P6AC 1YTPA 2NU4I 1CSOI 1SGQI 1CE3A 1OMUA 2QQDA 3SEKC 2N52A 1KMAA 2GKRI 1IY6A 2ARPF 2ERWA 1SGDI 2LEOA 2GKVA 1LR7A 1N13A 5JHWC 1Z7KB 2QQCA 1M8BA 1HDLA 1CT4I 2OVOA 1OYVI 1TIHA 2NU2I 1CGJI 2NU1I 1IW4A 1SGYI 1LR8A 1AN1I 2KMOA 1CHOI 1SGPI 2SGFI 2JXDA 2B0UC 1BUSA 1TUSA 1SGRI 3B4VC 1HJAI 1DS3I 1CT0I 1OMTA 2SGEI 1DS2I 2F3CI 2KCXA 3OVOA 4SGBI 1UUCA 4OVOA 1MT1A 1Y1CA 2V53A 1SGNI 1TBRR 1NUBA 4GI3C 2NU3I 2BUSA 5DAEA 1OVOA 1M8CA 1YU6C 1UVFA 2M5XA 2N17A
chains in the Genus database with same CATH superfamily
2KMRA 2WCYA 3OXLA 1WKXA 3R5CA 2JZMA 3UGLA 1H0ZA 1CGII 3VE5A 9WGAA 4HGUA 1TURA 1W3SA 1TOTA 4UXJA 5J8FA 2JYYA 4MPIA 2Y0MA 5E3PA 5HQ8A 2GKTI 3KY9A 2SGQI 1TBQR 2N71A 2SGPI 5EX3A 2NU0I 2KMQA 1PCEA 1IY5A 1P9ZA 1ULNA 2QPOA 2B8TA 3PDNA 1HPTA 3RU0A 2SGDI 5E3QA 1Y8FA 1R79A 3UFFA 1VDDA 2YQPA 3E59A 2X3TA 1TGSI 1W4RA 3QTLD 2K9HA 1LR9A 1R0RI 2E73A 3OXFA 2V1CC 2KMPA 4DNCA 1PJUA 1UVGA 2XRCA 2GVIA 1RFHA 1ULMA 1Y1BA 2WVJA 1CT2I 2E5RA 3FSXA 3HH2C 5HI7A 3SGQI 4B6DA 3SGBI 5CCLA 1U5KA 1PTQA 1BMOA 1SGEI 1WTJA 2X52A 2YUUA 1WGTA 2CWHA 2FNFX 1PPFI 2M5XA 3TJQA 3FSYA 1ULKA 1FYBA 2QQEA 2P6AC 1YTPA 2JW6A 2UVOA 2NU4I 2OD1A 5FUWA 1CSOI 1SGQI 1CE3A 2A20A 1OMUA 3TO6A 3TOAA 1S20A 2QQDA 2OU2A 4AMLA 3SEKC 3UOEA 2DKVA 3BJIA 2N52A 4WP4A 2ODDA 1KMAA 2JA1A 2GKRI 1K7VA 1IY6A 3D00A 3FC3A 1FARA 2ARPF 2ELIA 4JCVE 1MJ9A 2ROWA 2ERWA 3E2IA 1NXUA 2DB6A 1SGDI 2RC4A 5FUVA 2LEOA 1KBFA 1YU6C 2ORVA 2GKVA 1LR7A 1WGCA 4E1RA 1N13A 1K7TA 1V1IA 3GOXA 1XA6A 5JHWC 1Z7KB 3VDPA 1FY7A 1UHAA 4A24A 2QQCA 5EX0A 2N1AB 1M8BA 1HDLA 1CT4I 2OVOA 1OYVI 3QWPA 1TIHA 3OXGA 1K7UA 2WGCA 2NU2I 4UXIA 1CGJI 3OL0A 2CWFA 1PTRA 2NU1I 1IW4A 1SGYI 1XX6A 3MEKA 3TO7A 1LR8A 1TBNA 4FKDA 1AN1I 1X74A 2CWGA 3UEJA 2KMOA 1CHOI 2SGFI 2JXDA 2B0UC 5E3RA 1BUSA 1TUSA 1P9GA 2L7XA 2LB7A 2ENNA 5FUXA 3UEYA 3UGIA 1SGRI 2L8EA 2W0TA 3B4VC 2VRWB 3VDUA 1HJAI 1DS3I 1CT0I 1OMTA 2UZ3A 3TO9A 2DIPA 2SGEI 2J87A 1XBTA 3QAHA 2ENZA 1DS2I 1MJAA 5J8CA 1Z2IA 2F3CI 2KCXA 2RIJA 3OVOA 1HEVA 4SGBI 1UUCA 1X4SA 1Q9BA 1KBEA 3R5BA 4OVOA 1MT1A 1Y1CA 2V53A 3R5AA 2LUYA 3R5DA 4UXHA 2V1CA 4L9MA 1SGNI 1FAQA 1TBRR 1NUBA 5CCMA 2ORWA 2PQ8A 2QQ0A 1V1HA 1MJBA 4GI3C 2OZUA 5FUYA 3UGDA 7WGAA 2NU3I 2BUSA 5DAEA 3CXLA 4E1PA 2CJSC 1OVOA 1TBOA 3TOBA 1M8CA 1SGPI 1UVFA 2GIVA 2J9RA 2N17A
chains in the Genus database with same CATH topology
2KMRA 2WCYA 3OXLA 2JZMA 3UGLA 1H0ZA 1CGII 3VE5A 4HGUA 1TURA 1W3SA 1TOTA 4UXJA 2JYYA 5HQ8A 2GKTI 3KY9A 2SGQI 1TBQR 2N71A 2SGPI 5EX3A 2NU0I 2KMQA 1PCEA 1IY5A 2QPOA 2B8TA 3PDNA 1HPTA 3RU0A 2SGDI 1Y8FA 1R79A 3UFFA 1VDDA 2YQPA 3E59A 1TGSI 1W4RA 3QTLD 2K9HA 1LR9A 1R0RI 2E73A 3OXFA 2V1CC 2KMPA 1PJUA 1UVGA 2XRCA 2GVIA 1RFHA 1Y1BA 2WVJA 3HH2C 1CT2I 2E5RA 5HI7A 5CCLA 3SGQI 4B6DA 3SGBI 1U5KA 1PTQA 1BMOA 1SGEI 2YUUA 2FNFX 2M5XA 1PPFI 3TJQA 1FYBA 2QQEA 2P6AC 1YTPA 2JW6A 2NU4I 2OD1A 5FUWA 1CSOI 1SGQI 1CE3A 2A20A 1OMUA 2QQDA 3SEKC 3BJIA 2N52A 2ODDA 1KMAA 2JA1A 2GKRI 1IY6A 3D00A 3FC3A 1FARA 2ARPF 2ELIA 4JCVE 2ROWA 2ERWA 3E2IA 2DB6A 1SGDI 5FUVA 2LEOA 1KBFA 2ORVA 2GKVA 1LR7A 4E1RA 1N13A 1V1IA 3GOXA 1XA6A 5JHWC 1Z7KB 3VDPA 4A24A 2QQCA 5EX0A 2N1AB 1M8BA 1HDLA 1CT4I 2OVOA 1OYVI 3QWPA 1TIHA 3OXGA 2NU2I 4UXIA 1CGJI 3OL0A 1PTRA 2NU1I 1IW4A 1SGYI 1XX6A 3MEKA 3UGIA 1LR8A 1TBNA 4FKDA 1AN1I 1X74A 3UEJA 1SGPI 1CHOI 2KMOA 2SGFI 2JXDA 2B0UC 1BUSA 1TUSA 2L7XA 5FUXA 2ENNA 3UEYA 1SGRI 2L8EA 2W0TA 3B4VC 2VRWB 3VDUA 1HJAI 1DS3I 1CT0I 1OMTA 2UZ3A 2DIPA 2SGEI 2J87A 1XBTA 2ENZA 1DS2I 2F3CI 2KCXA 3OVOA 4SGBI 1UUCA 1X4SA 1KBEA 4OVOA 1MT1A 1Y1CA 2V53A 2LUYA 4UXHA 2V1CA 4L9MA 1SGNI 1FAQA 1TBRR 1NUBA 5CCMA 2ORWA 2QQ0A 3UGDA 1V1HA 4GI3C 5FUYA 2NU3I 2BUSA 5DAEA 3CXLA 4E1PA 2CJSC 1OVOA 1TBOA 1M8CA 1YU6C 1UVFA 2J9RA 2N17A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KMR A;  2WCY A;  2JZM A;  1H0Z A;  1CGI I;  4HGU A;  1TUR A;  2JYY A;  2GKT I;  2SGQ I;  1TBQ R;  2N71 A;  2SGP I;  2NU0 I;  2KMQ A;  1PCE A;  1IY5 A;  1HPT A;  2SGD I;  1TGS I;  3QTL D;  1LR9 A;  1R0R I;  2KMP A;  1PJU A;  1UVG A;  2XRC A;  1Y1B A;  3HH2 C;  1CT2 I;  3SGQ I;  3SGB I;  1BMO A;  1SGE I;  1PPF I;  3TJQ A;  1FYB A;  2P6A C;  1YTP A;  2NU4 I;  1CSO I;  1SGQ I;  1CE3 A;  1OMU A;  2QQD A;  3SEK C;  2N52 A;  1KMA A;  2GKR I;  1IY6 A;  2ARP F;  2ERW A;  1SGD I;  2LEO A;  2GKV A;  1LR7 A;  1N13 A;  5JHW C;  1Z7K B;  2QQC A;  1M8B A;  1HDL A;  1CT4 I;  2OVO A;  1OYV I;  1TIH A;  2NU2 I;  1CGJ I;  2NU1 I;  1IW4 A;  1SGY I;  1LR8 A;  1AN1 I;  2KMO A;  1CHO I;  1SGP I;  2SGF I;  2JXD A;  2B0U C;  1BUS A;  1TUS A;  1SGR I;  3B4V C;  1HJA I;  1DS3 I;  1CT0 I;  1OMT A;  2SGE I;  1DS2 I;  2F3C I;  2KCX A;  3OVO A;  4SGB I;  1UUC A;  4OVO A;  1MT1 A;  1Y1C A;  2V53 A;  1SGN I;  1TBR R;  1NUB A;  4GI3 C;  2NU3 I;  2BUS A;  5DAE A;  1OVO A;  1M8C A;  1YU6 C;  1UVF A;  2M5X A;  2N17 A; 
#chains in the Genus database with same CATH topology
 2KMR A;  2WCY A;  3OXL A;  1WKX A;  3R5C A;  2JZM A;  3UGL A;  1H0Z A;  1CGI I;  3VE5 A;  9WGA A;  4HGU A;  1TUR A;  1W3S A;  1TOT A;  4UXJ A;  5J8F A;  2JYY A;  4MPI A;  2Y0M A;  5E3P A;  5HQ8 A;  2GKT I;  3KY9 A;  2SGQ I;  1TBQ R;  2N71 A;  2SGP I;  5EX3 A;  2NU0 I;  2KMQ A;  1PCE A;  1IY5 A;  1P9Z A;  1ULN A;  2QPO A;  2B8T A;  3PDN A;  1HPT A;  3RU0 A;  2SGD I;  5E3Q A;  1Y8F A;  1R79 A;  3UFF A;  1VDD A;  2YQP A;  3E59 A;  2X3T A;  1TGS I;  1W4R A;  3QTL D;  2K9H A;  1LR9 A;  1R0R I;  2E73 A;  3OXF A;  2V1C C;  2KMP A;  4DNC A;  1PJU A;  1UVG A;  2XRC A;  2GVI A;  1RFH A;  1ULM A;  1Y1B A;  2WVJ A;  1CT2 I;  2E5R A;  3FSX A;  3HH2 C;  5HI7 A;  3SGQ I;  4B6D A;  3SGB I;  5CCL A;  1U5K A;  1PTQ A;  1BMO A;  1SGE I;  1WTJ A;  2X52 A;  2YUU A;  1WGT A;  2CWH A;  2FNF X;  1PPF I;  2M5X A;  3TJQ A;  3FSY A;  1ULK A;  1FYB A;  2QQE A;  2P6A C;  1YTP A;  2JW6 A;  2UVO A;  2NU4 I;  2OD1 A;  5FUW A;  1CSO I;  1SGQ I;  1CE3 A;  2A20 A;  1OMU A;  3TO6 A;  3TOA A;  1S20 A;  2QQD A;  2OU2 A;  4AML A;  3SEK C;  3UOE A;  2DKV A;  3BJI A;  2N52 A;  4WP4 A;  2ODD A;  1KMA A;  2JA1 A;  2GKR I;  1K7V A;  1IY6 A;  3D00 A;  3FC3 A;  1FAR A;  2ARP F;  2ELI A;  4JCV E;  1MJ9 A;  2ROW A;  2ERW A;  3E2I A;  1NXU A;  2DB6 A;  1SGD I;  2RC4 A;  5FUV A;  2LEO A;  1KBF A;  1YU6 C;  2ORV A;  2GKV A;  1LR7 A;  1WGC A;  4E1R A;  1N13 A;  1K7T A;  1V1I A;  3GOX A;  1XA6 A;  5JHW C;  1Z7K B;  3VDP A;  1FY7 A;  1UHA A;  4A24 A;  2QQC A;  5EX0 A;  2N1A B;  1M8B A;  1HDL A;  1CT4 I;  2OVO A;  1OYV I;  3QWP A;  1TIH A;  3OXG A;  1K7U A;  2WGC A;  2NU2 I;  4UXI A;  1CGJ I;  3OL0 A;  2CWF A;  1PTR A;  2NU1 I;  1IW4 A;  1SGY I;  1XX6 A;  3MEK A;  3TO7 A;  1LR8 A;  1TBN A;  4FKD A;  1AN1 I;  1X74 A;  2CWG A;  3UEJ A;  2KMO A;  1CHO I;  2SGF I;  2JXD A;  2B0U C;  5E3R A;  1BUS A;  1TUS A;  1P9G A;  2L7X A;  2LB7 A;  2ENN A;  5FUX A;  3UEY A;  3UGI A;  1SGR I;  2L8E A;  2W0T A;  3B4V C;  2VRW B;  3VDU A;  1HJA I;  1DS3 I;  1CT0 I;  1OMT A;  2UZ3 A;  3TO9 A;  2DIP A;  2SGE I;  2J87 A;  1XBT A;  3QAH A;  2ENZ A;  1DS2 I;  1MJA A;  5J8C A;  1Z2I A;  2F3C I;  2KCX A;  2RIJ A;  3OVO A;  1HEV A;  4SGB I;  1UUC A;  1X4S A;  1Q9B A;  1KBE A;  3R5B A;  4OVO A;  1MT1 A;  1Y1C A;  2V53 A;  3R5A A;  2LUY A;  3R5D A;  4UXH A;  2V1C A;  4L9M A;  1SGN I;  1FAQ A;  1TBR R;  1NUB A;  5CCM A;  2ORW A;  2PQ8 A;  2QQ0 A;  1V1H A;  1MJB A;  4GI3 C;  2OZU A;  5FUY A;  3UGD A;  7WGA A;  2NU3 I;  2BUS A;  5DAE A;  3CXL A;  4E1P A;  2CJS C;  1OVO A;  1TBO A;  3TOB A;  1M8C A;  1SGP I;  1UVF A;  2GIV A;  2J9R A;  2N17 A; 
#chains in the Genus database with same CATH homology
 2KMR A;  2WCY A;  3OXL A;  2JZM A;  3UGL A;  1H0Z A;  1CGI I;  3VE5 A;  4HGU A;  1TUR A;  1W3S A;  1TOT A;  4UXJ A;  2JYY A;  5HQ8 A;  2GKT I;  3KY9 A;  2SGQ I;  1TBQ R;  2N71 A;  2SGP I;  5EX3 A;  2NU0 I;  2KMQ A;  1PCE A;  1IY5 A;  2QPO A;  2B8T A;  3PDN A;  1HPT A;  3RU0 A;  2SGD I;  1Y8F A;  1R79 A;  3UFF A;  1VDD A;  2YQP A;  3E59 A;  1TGS I;  1W4R A;  3QTL D;  2K9H A;  1LR9 A;  1R0R I;  2E73 A;  3OXF A;  2V1C C;  2KMP A;  1PJU A;  1UVG A;  2XRC A;  2GVI A;  1RFH A;  1Y1B A;  2WVJ A;  3HH2 C;  1CT2 I;  2E5R A;  5HI7 A;  5CCL A;  3SGQ I;  4B6D A;  3SGB I;  1U5K A;  1PTQ A;  1BMO A;  1SGE I;  2YUU A;  2FNF X;  2M5X A;  1PPF I;  3TJQ A;  1FYB A;  2QQE A;  2P6A C;  1YTP A;  2JW6 A;  2NU4 I;  2OD1 A;  5FUW A;  1CSO I;  1SGQ I;  1CE3 A;  2A20 A;  1OMU A;  2QQD A;  3SEK C;  3BJI A;  2N52 A;  2ODD A;  1KMA A;  2JA1 A;  2GKR I;  1IY6 A;  3D00 A;  3FC3 A;  1FAR A;  2ARP F;  2ELI A;  4JCV E;  2ROW A;  2ERW A;  3E2I A;  2DB6 A;  1SGD I;  5FUV A;  2LEO A;  1KBF A;  2ORV A;  2GKV A;  1LR7 A;  4E1R A;  1N13 A;  1V1I A;  3GOX A;  1XA6 A;  5JHW C;  1Z7K B;  3VDP A;  4A24 A;  2QQC A;  5EX0 A;  2N1A B;  1M8B A;  1HDL A;  1CT4 I;  2OVO A;  1OYV I;  3QWP A;  1TIH A;  3OXG A;  2NU2 I;  4UXI A;  1CGJ I;  3OL0 A;  1PTR A;  2NU1 I;  1IW4 A;  1SGY I;  1XX6 A;  3MEK A;  3UGI A;  1LR8 A;  1TBN A;  4FKD A;  1AN1 I;  1X74 A;  3UEJ A;  1SGP I;  1CHO I;  2KMO A;  2SGF I;  2JXD A;  2B0U C;  1BUS A;  1TUS A;  2L7X A;  5FUX A;  2ENN A;  3UEY A;  1SGR I;  2L8E A;  2W0T A;  3B4V C;  2VRW B;  3VDU A;  1HJA I;  1DS3 I;  1CT0 I;  1OMT A;  2UZ3 A;  2DIP A;  2SGE I;  2J87 A;  1XBT A;  2ENZ A;  1DS2 I;  2F3C I;  2KCX A;  3OVO A;  4SGB I;  1UUC A;  1X4S A;  1KBE A;  4OVO A;  1MT1 A;  1Y1C A;  2V53 A;  2LUY A;  4UXH A;  2V1C A;  4L9M A;  1SGN I;  1FAQ A;  1TBR R;  1NUB A;  5CCM A;  2ORW A;  2QQ0 A;  3UGD A;  1V1H A;  4GI3 C;  5FUY A;  2NU3 I;  2BUS A;  5DAE A;  3CXL A;  4E1P A;  2CJS C;  1OVO A;  1TBO A;  1M8C A;  1YU6 C;  1UVF A;  2J9R A;  2N17 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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