1LR8A

Crystal structure of fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue d-myo-inositol hexasulphate (ins6s)
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
73
structure length
73
Chain Sequence
ETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGKCK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hormone/growth factor
molecule keywords Follistatin
publication title Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
pubmed doi rcsb
source organism Rattus norvegicus
total genus 13
structure length 73
sequence length 73
ec nomenclature
pdb deposition date 2002-05-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07648 Kazal_2 Kazal-type serine protease inhibitor domain
A PF09289 FOLN Follistatin/Osteonectin-like EGF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 1lr8A00
4GI3C 1IW4A 2KMPA 1R0RI 2KMOA 1CGII 2BUSA 1PCEA 1UUCA 3TJQA 2P6AC 2SGDI 1CSOI 3QTLD 2SGPI 1Z7KB 1PPFI 2ARPF 1SGRI 2XRCA 1OYVI 1TUSA 1SGEI 2GKVA 2NU0I 1MT1A 1IY6A 5DAEA 2JXDA 2SGFI 1SGQI 5JHWC 1CT2I 1YU6C 3B4VC 4HGUA 1KMAA 2N52A 2QQCA 1PJUA 1YTPA 2KMQA 1IY5A 2M5XA 1SGNI 2OVOA 2V53A 1M8CA 1LR7A 1OMUA 2GKTI 3HH2C 2KMRA 2QQDA 1OMTA 1SGPI 3SEKC 2WCYA 2JYYA 4OVOA 1HDLA 1CT4I 1AN1I 2B0UC 2ERWA 1BMOA 1SGDI 1H0ZA 2KCXA 1Y1CA 1TURA 1FYBA 1LR9A 1HJAI 2N71A 2GKRI 3OVOA 3SGQI 1CGJI 1BUSA 1LR8A 1DS3I 2JZMA 2SGQI 1DS2I 1UVFA 1Y1BA 4SGBI 1N13A 2N17A 3SGBI 1SGYI 2NU2I 1CHOI 1CE3A 2NU1I 1HPTA 1CT0I 1OVOA 2SGEI 1TGSI 1M8BA 1UVGA 2NU4I 1TBQR 2LEOA 1NUBA 2F3CI 1TBRR 2NU3I 1TIHA
chains in the Genus database with same CATH superfamily
4GI3C 4UXIA 5E3PA 2DIPA 3D00A 3FSYA 2KMPA 5HI7A 3TOAA 1IW4A 1FY7A 1P9GA 1R0RI 3E2IA 2KMOA 1CGII 2BUSA 1PCEA 4UXJA 4A24A 2ODDA 2OD1A 1W4RA 1UUCA 2E5RA 1W3SA 3TJQA 2L8EA 7WGAA 2GIVA 2P6AC 1Q9BA 2SGDI 1CSOI 3PDNA 3UOEA 1MJ9A 2SGPI 3QTLD 3UEYA 4MPIA 1KBEA 1Z7KB 1Z2IA 3BJIA 4L9MA 4DNCA 2OU2A 1PPFI 2ARPF 1SGRI 2XRCA 1ULKA 2ENZA 1OYVI 1TUSA 1SGEI 2ORVA 1WGCA 2GKVA 2N1AB 2NU0I 2WVJA 3TO9A 2LB7A 1MT1A 2ENNA 1X4SA 5DAEA 1IY6A 3MEKA 2UZ3A 2JXDA 2SGFI 3KY9A 1KBFA 1SGQI 2WGCA 2JA1A 3QWPA 5E3RA 5JHWC 1CT2I 1YU6C 1Y8FA 3B4VC 1HEVA 1NXUA 4HGUA 2L7XA 1XX6A 1KMAA 2N52A 2RIJA 5CCMA 2CWGA 5FUYA 2QQCA 4B6DA 1TBNA 1PJUA 1YTPA 2CWFA 2KMQA 2QPOA 2V1CA 2X3TA 1IY5A 2M5XA 2CWHA 1SGNI 3R5DA 1ULMA 2ELIA 2OZUA 2ROWA 3RU0A 3TOBA 2JW6A 5FUVA 1PTRA 2OVOA 2V53A 3UGDA 1FAQA 1M8CA 1LR7A 2YQPA 1OMUA 2GKTI 2ORWA 1XBTA 2J9RA 2VRWB 3OXFA 3HH2C 3VDPA 2KMRA 2QQDA 1OMTA 4E1PA 1SGPI 3TO7A 1WTJA 3UGIA 3SEKC 2WCYA 2JYYA 4OVOA 4E1RA 1MJBA 1HDLA 1CT4I 1AN1I 2B0UC 1R79A 2FNFX 4WP4A 1TBOA 2ERWA 4JCVE 2B8TA 5EX0A 1BMOA 1SGDI 1XA6A 3OL0A 1H0ZA 2KCXA 1Y1CA 1TURA 4FKDA 1FYBA 2K9HA 1LR9A 1HJAI 2N71A 4UXHA 4AMLA 1ULNA 1PTQA 5FUWA 1S20A 2GKRI 3CXLA 3OVOA 1UHAA 2E73A 9WGAA 5J8CA 3FC3A 1P9ZA 3R5BA 3OXGA 1WGTA 2A20A 1V1HA 1CGJI 3SGQI 1X74A 3UEJA 3VE5A 5HQ8A 1BUSA 1LR8A 1DS3I 2GVIA 1K7UA 2X52A 3FSXA 2JZMA 2SGQI 2PQ8A 2RC4A 3VDUA 1DS2I 2V1CC 1VDDA 5J8FA 2UVOA 3GOXA 1WKXA 3R5CA 1UVFA 1Y1BA 1MJAA 4SGBI 5E3QA 1V1IA 5CCLA 2J87A 5FUXA 1N13A 2CJSC 2N17A 3SGBI 1U5KA 5EX3A 1SGYI 2NU2I 3QAHA 2QQ0A 3OXLA 1CHOI 3E59A 1CE3A 2NU1I 1HPTA 1CT0I 3UFFA 2LUYA 1OVOA 2SGEI 1K7VA 1TGSI 2YUUA 3R5AA 1M8BA 2DKVA 1RFHA 1UVGA 2Y0MA 3TO6A 2DB6A 1TBQR 2LEOA 1TOTA 1FARA 2NU4I 3UGLA 1K7TA 1NUBA 2QQEA 2W0TA 2F3CI 1TBRR 2NU3I 1TIHA
chains in the Genus database with same CATH topology
4GI3C 4UXIA 2DIPA 3D00A 5HI7A 2KMPA 1IW4A 1R0RI 3E2IA 2KMOA 1CGII 2BUSA 1PCEA 4UXJA 4A24A 2ODDA 2OD1A 1W4RA 1UUCA 2E5RA 1W3SA 3TJQA 2L8EA 2P6AC 3PDNA 2SGDI 1CSOI 3QTLD 2SGPI 3UEYA 1KBEA 1Z7KB 3BJIA 4L9MA 1PPFI 2ARPF 1SGRI 2XRCA 2ENZA 1OYVI 1TUSA 1SGEI 2ORVA 2GKVA 2N1AB 2NU0I 2WVJA 1MT1A 2ENNA 1X4SA 5DAEA 1IY6A 3MEKA 2UZ3A 2JXDA 2SGFI 3KY9A 1KBFA 1SGQI 2JA1A 3QWPA 5JHWC 1CT2I 1YU6C 1Y8FA 3B4VC 4HGUA 2L7XA 1XX6A 1KMAA 2N52A 5CCMA 5FUYA 2QQCA 4B6DA 1TBNA 1PJUA 1YTPA 2KMQA 1IY5A 2QPOA 2V1CA 2M5XA 1SGNI 2ELIA 2ROWA 3RU0A 2JW6A 5FUVA 1PTRA 2OVOA 2V53A 3UGDA 1FAQA 1M8CA 1LR7A 2YQPA 1OMUA 2GKTI 2ORWA 1XBTA 2J9RA 2VRWB 3OXFA 3HH2C 3VDPA 2KMRA 2QQDA 1OMTA 4E1PA 1SGPI 3UGIA 3SEKC 2WCYA 2JYYA 4OVOA 4E1RA 1HDLA 1CT4I 1AN1I 2B0UC 1R79A 2FNFX 1TBOA 2ERWA 4JCVE 2B8TA 5EX0A 1BMOA 1SGDI 1XA6A 3OL0A 1H0ZA 2KCXA 1Y1CA 1TURA 4FKDA 1FYBA 2K9HA 1LR9A 1HJAI 2N71A 4UXHA 1PTQA 5FUWA 2GKRI 3CXLA 3OVOA 2E73A 3FC3A 3OXGA 2A20A 3SGQI 1V1HA 1CGJI 3UEJA 1X74A 3VE5A 5HQ8A 1BUSA 1LR8A 1DS3I 2GVIA 2JZMA 2SGQI 3VDUA 1DS2I 2V1CC 1VDDA 3GOXA 1UVFA 1Y1BA 4SGBI 1V1IA 5CCLA 2J87A 5FUXA 1N13A 2CJSC 2N17A 3SGBI 1U5KA 5EX3A 1SGYI 2NU2I 2QQ0A 3OXLA 1CHOI 3E59A 1CE3A 2NU1I 1HPTA 1CT0I 3UFFA 2LUYA 1OVOA 2SGEI 1TGSI 2YUUA 1M8BA 1RFHA 1UVGA 2DB6A 1TBQR 2LEOA 1TOTA 1FARA 2NU4I 3UGLA 1NUBA 2QQEA 2W0TA 2F3CI 1TBRR 2NU3I 1TIHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GI3 C;  1IW4 A;  2KMP A;  1R0R I;  2KMO A;  1CGI I;  2BUS A;  1PCE A;  1UUC A;  3TJQ A;  2P6A C;  2SGD I;  1CSO I;  3QTL D;  2SGP I;  1Z7K B;  1PPF I;  2ARP F;  1SGR I;  2XRC A;  1OYV I;  1TUS A;  1SGE I;  2GKV A;  2NU0 I;  1MT1 A;  1IY6 A;  5DAE A;  2JXD A;  2SGF I;  1SGQ I;  5JHW C;  1CT2 I;  1YU6 C;  3B4V C;  4HGU A;  1KMA A;  2N52 A;  2QQC A;  1PJU A;  1YTP A;  2KMQ A;  1IY5 A;  2M5X A;  1SGN I;  2OVO A;  2V53 A;  1M8C A;  1LR7 A;  1OMU A;  2GKT I;  3HH2 C;  2KMR A;  2QQD A;  1OMT A;  1SGP I;  3SEK C;  2WCY A;  2JYY A;  4OVO A;  1HDL A;  1CT4 I;  1AN1 I;  2B0U C;  2ERW A;  1BMO A;  1SGD I;  1H0Z A;  2KCX A;  1Y1C A;  1TUR A;  1FYB A;  1LR9 A;  1HJA I;  2N71 A;  2GKR I;  3OVO A;  3SGQ I;  1CGJ I;  1BUS A;  1LR8 A;  1DS3 I;  2JZM A;  2SGQ I;  1DS2 I;  1UVF A;  1Y1B A;  4SGB I;  1N13 A;  2N17 A;  3SGB I;  1SGY I;  2NU2 I;  1CHO I;  1CE3 A;  2NU1 I;  1HPT A;  1CT0 I;  1OVO A;  2SGE I;  1TGS I;  1M8B A;  1UVG A;  2NU4 I;  1TBQ R;  2LEO A;  1NUB A;  2F3C I;  1TBR R;  2NU3 I;  1TIH A; 
#chains in the Genus database with same CATH topology
 4GI3 C;  4UXI A;  5E3P A;  2DIP A;  3D00 A;  3FSY A;  2KMP A;  5HI7 A;  3TOA A;  1IW4 A;  1FY7 A;  1P9G A;  1R0R I;  3E2I A;  2KMO A;  1CGI I;  2BUS A;  1PCE A;  4UXJ A;  4A24 A;  2ODD A;  2OD1 A;  1W4R A;  1UUC A;  2E5R A;  1W3S A;  3TJQ A;  2L8E A;  7WGA A;  2GIV A;  2P6A C;  1Q9B A;  2SGD I;  1CSO I;  3PDN A;  3UOE A;  1MJ9 A;  2SGP I;  3QTL D;  3UEY A;  4MPI A;  1KBE A;  1Z7K B;  1Z2I A;  3BJI A;  4L9M A;  4DNC A;  2OU2 A;  1PPF I;  2ARP F;  1SGR I;  2XRC A;  1ULK A;  2ENZ A;  1OYV I;  1TUS A;  1SGE I;  2ORV A;  1WGC A;  2GKV A;  2N1A B;  2NU0 I;  2WVJ A;  3TO9 A;  2LB7 A;  1MT1 A;  2ENN A;  1X4S A;  5DAE A;  1IY6 A;  3MEK A;  2UZ3 A;  2JXD A;  2SGF I;  3KY9 A;  1KBF A;  1SGQ I;  2WGC A;  2JA1 A;  3QWP A;  5E3R A;  5JHW C;  1CT2 I;  1YU6 C;  1Y8F A;  3B4V C;  1HEV A;  1NXU A;  4HGU A;  2L7X A;  1XX6 A;  1KMA A;  2N52 A;  2RIJ A;  5CCM A;  2CWG A;  5FUY A;  2QQC A;  4B6D A;  1TBN A;  1PJU A;  1YTP A;  2CWF A;  2KMQ A;  2QPO A;  2V1C A;  2X3T A;  1IY5 A;  2M5X A;  2CWH A;  1SGN I;  3R5D A;  1ULM A;  2ELI A;  2OZU A;  2ROW A;  3RU0 A;  3TOB A;  2JW6 A;  5FUV A;  1PTR A;  2OVO A;  2V53 A;  3UGD A;  1FAQ A;  1M8C A;  1LR7 A;  2YQP A;  1OMU A;  2GKT I;  2ORW A;  1XBT A;  2J9R A;  2VRW B;  3OXF A;  3HH2 C;  3VDP A;  2KMR A;  2QQD A;  1OMT A;  4E1P A;  1SGP I;  3TO7 A;  1WTJ A;  3UGI A;  3SEK C;  2WCY A;  2JYY A;  4OVO A;  4E1R A;  1MJB A;  1HDL A;  1CT4 I;  1AN1 I;  2B0U C;  1R79 A;  2FNF X;  4WP4 A;  1TBO A;  2ERW A;  4JCV E;  2B8T A;  5EX0 A;  1BMO A;  1SGD I;  1XA6 A;  3OL0 A;  1H0Z A;  2KCX A;  1Y1C A;  1TUR A;  4FKD A;  1FYB A;  2K9H A;  1LR9 A;  1HJA I;  2N71 A;  4UXH A;  4AML A;  1ULN A;  1PTQ A;  5FUW A;  1S20 A;  2GKR I;  3CXL A;  3OVO A;  1UHA A;  2E73 A;  9WGA A;  5J8C A;  3FC3 A;  1P9Z A;  3R5B A;  3OXG A;  1WGT A;  2A20 A;  1V1H A;  1CGJ I;  3SGQ I;  1X74 A;  3UEJ A;  3VE5 A;  5HQ8 A;  1BUS A;  1LR8 A;  1DS3 I;  2GVI A;  1K7U A;  2X52 A;  3FSX A;  2JZM A;  2SGQ I;  2PQ8 A;  2RC4 A;  3VDU A;  1DS2 I;  2V1C C;  1VDD A;  5J8F A;  2UVO A;  3GOX A;  1WKX A;  3R5C A;  1UVF A;  1Y1B A;  1MJA A;  4SGB I;  5E3Q A;  1V1I A;  5CCL A;  2J87 A;  5FUX A;  1N13 A;  2CJS C;  2N17 A;  3SGB I;  1U5K A;  5EX3 A;  1SGY I;  2NU2 I;  3QAH A;  2QQ0 A;  3OXL A;  1CHO I;  3E59 A;  1CE3 A;  2NU1 I;  1HPT A;  1CT0 I;  3UFF A;  2LUY A;  1OVO A;  2SGE I;  1K7V A;  1TGS I;  2YUU A;  3R5A A;  1M8B A;  2DKV A;  1RFH A;  1UVG A;  2Y0M A;  3TO6 A;  2DB6 A;  1TBQ R;  2LEO A;  1TOT A;  1FAR A;  2NU4 I;  3UGL A;  1K7T A;  1NUB A;  2QQE A;  2W0T A;  2F3C I;  1TBR R;  2NU3 I;  1TIH A; 
#chains in the Genus database with same CATH homology
 4GI3 C;  4UXI A;  2DIP A;  3D00 A;  5HI7 A;  2KMP A;  1IW4 A;  1R0R I;  3E2I A;  2KMO A;  1CGI I;  2BUS A;  1PCE A;  4UXJ A;  4A24 A;  2ODD A;  2OD1 A;  1W4R A;  1UUC A;  2E5R A;  1W3S A;  3TJQ A;  2L8E A;  2P6A C;  3PDN A;  2SGD I;  1CSO I;  3QTL D;  2SGP I;  3UEY A;  1KBE A;  1Z7K B;  3BJI A;  4L9M A;  1PPF I;  2ARP F;  1SGR I;  2XRC A;  2ENZ A;  1OYV I;  1TUS A;  1SGE I;  2ORV A;  2GKV A;  2N1A B;  2NU0 I;  2WVJ A;  1MT1 A;  2ENN A;  1X4S A;  5DAE A;  1IY6 A;  3MEK A;  2UZ3 A;  2JXD A;  2SGF I;  3KY9 A;  1KBF A;  1SGQ I;  2JA1 A;  3QWP A;  5JHW C;  1CT2 I;  1YU6 C;  1Y8F A;  3B4V C;  4HGU A;  2L7X A;  1XX6 A;  1KMA A;  2N52 A;  5CCM A;  5FUY A;  2QQC A;  4B6D A;  1TBN A;  1PJU A;  1YTP A;  2KMQ A;  1IY5 A;  2QPO A;  2V1C A;  2M5X A;  1SGN I;  2ELI A;  2ROW A;  3RU0 A;  2JW6 A;  5FUV A;  1PTR A;  2OVO A;  2V53 A;  3UGD A;  1FAQ A;  1M8C A;  1LR7 A;  2YQP A;  1OMU A;  2GKT I;  2ORW A;  1XBT A;  2J9R A;  2VRW B;  3OXF A;  3HH2 C;  3VDP A;  2KMR A;  2QQD A;  1OMT A;  4E1P A;  1SGP I;  3UGI A;  3SEK C;  2WCY A;  2JYY A;  4OVO A;  4E1R A;  1HDL A;  1CT4 I;  1AN1 I;  2B0U C;  1R79 A;  2FNF X;  1TBO A;  2ERW A;  4JCV E;  2B8T A;  5EX0 A;  1BMO A;  1SGD I;  1XA6 A;  3OL0 A;  1H0Z A;  2KCX A;  1Y1C A;  1TUR A;  4FKD A;  1FYB A;  2K9H A;  1LR9 A;  1HJA I;  2N71 A;  4UXH A;  1PTQ A;  5FUW A;  2GKR I;  3CXL A;  3OVO A;  2E73 A;  3FC3 A;  3OXG A;  2A20 A;  3SGQ I;  1V1H A;  1CGJ I;  3UEJ A;  1X74 A;  3VE5 A;  5HQ8 A;  1BUS A;  1LR8 A;  1DS3 I;  2GVI A;  2JZM A;  2SGQ I;  3VDU A;  1DS2 I;  2V1C C;  1VDD A;  3GOX A;  1UVF A;  1Y1B A;  4SGB I;  1V1I A;  5CCL A;  2J87 A;  5FUX A;  1N13 A;  2CJS C;  2N17 A;  3SGB I;  1U5K A;  5EX3 A;  1SGY I;  2NU2 I;  2QQ0 A;  3OXL A;  1CHO I;  3E59 A;  1CE3 A;  2NU1 I;  1HPT A;  1CT0 I;  3UFF A;  2LUY A;  1OVO A;  2SGE I;  1TGS I;  2YUU A;  1M8B A;  1RFH A;  1UVG A;  2DB6 A;  1TBQ R;  2LEO A;  1TOT A;  1FAR A;  2NU4 I;  3UGL A;  1NUB A;  2QQE A;  2W0T A;  2F3C I;  1TBR R;  2NU3 I;  1TIH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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