2KMQA

Solution structure of intermediate iib of leech-derived tryptase inhibitor, ldti.
Total Genus 5
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
5
sequence length
44
structure length
44
Chain Sequence
KKVCACPKILKPVCGSDGRTYANSCIARCNGVSIKSEGSCPTGI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Deciphering the structural basis that guides the oxidative folding of leech-derived tryptase inhibitor.
pubmed doi rcsb
molecule tags Hydrolase
source organism Hirudo medicinalis
molecule keywords Leech-derived tryptase inhibitor C
total genus 5
structure length 44
sequence length 44
ec nomenclature
pdb deposition date 2009-08-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00050 Kazal_1 Kazal-type serine protease inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 2kmqA00
4GI3C 1TURA 1UVFA 1SGQI 1LR9A 2NU0I 1TBRR 2KCXA 2N71A 1KMAA 1TGSI 2JXDA 2KMPA 2LEOA 2SGDI 2QQCA 2NU3I 3SEKC 1LR8A 2SGQI 1OMTA 1M8CA 1OVOA 1SGRI 2N52A 1HDLA 1LR7A 1IY6A 2N17A 3TJQA 1SGDI 2B0UC 1OMUA 1M8BA 1CSOI 1CT0I 1BMOA 1DS2I 2KMOA 2WCYA 4OVOA 1IY5A 1CGII 1Y1CA 2V53A 1SGPI 1CHOI 1SGYI 1SGNI 2F3CI 1CT2I 1IW4A 1NUBA 1OYVI 1Y1BA 3B4VC 1N13A 2P6AC 1UVGA 1AN1I 2XRCA 1PPFI 2NU2I 1TIHA 1MT1A 1HPTA 5DAEA 1PCEA 1YU6C 1H0ZA 1TBQR 2QQDA 2SGPI 1FYBA 3OVOA 1SGEI 3SGQI 1HJAI 1CGJI 3QTLD 4SGBI 2ARPF 3HH2C 2JZMA 2GKRI 2ERWA 2GKTI 1CT4I 1DS3I 1CE3A 5JHWC 1YTPA 2GKVA 2JYYA 2KMRA 1TUSA 2OVOA 2M5XA 2SGEI 3SGBI 1Z7KB 2NU1I 4HGUA 1PJUA 2SGFI 1UUCA 1BUSA 2NU4I 2BUSA 2KMQA 1R0RI
chains in the Genus database with same CATH superfamily
2J87A 3UOEA 5FUYA 4GI3C 1WGCA 1WGTA 3R5DA 1TURA 1UVFA 1SGQI 2J9RA 2DKVA 3VE5A 2OZUA 2RIJA 1LR9A 1WKXA 1K7UA 1XX6A 1VDDA 3UFFA 3RU0A 4AMLA 2ELIA 4E1PA 2NU0I 1TBRR 2CWHA 2KCXA 2N71A 3OL0A 1KMAA 1TGSI 2JXDA 2KMPA 2LEOA 2QQEA 2SGDI 2OD1A 3TOBA 4B6DA 2QQCA 2NU3I 3R5CA 3SEKC 1LR8A 1P9GA 2ODDA 2SGQI 1OMTA 1M8CA 2N1AB 2GVIA 1OVOA 1SGRI 2B8TA 2N52A 3UGIA 1HDLA 2CJSC 2CWFA 2ORVA 3D00A 1LR7A 1IY6A 2N17A 3TJQA 1SGDI 4E1RA 2B0UC 5FUVA 3FC3A 1OMUA 1M8BA 1CSOI 1CT0I 1BMOA 1DS2I 2KMOA 1PTRA 7WGAA 1XBTA 3E2IA 4DNCA 2ROWA 2UVOA 3TO7A 2WCYA 2V1CC 1X4SA 4OVOA 3UGDA 1ULKA 1PTQA 1P9ZA 1ULNA 4UXHA 3OXGA 5FUXA 5CCMA 1IY5A 1NXUA 3VDPA 1K7VA 1CGII 1Y1CA 5CCLA 2V53A 1S20A 1X74A 2KMQA 5E3RA 1SGPI 1CHOI 1SGYI 1SGNI 2F3CI 2X52A 2L7XA 3OXFA 1CT2I 1WTJA 3QWPA 5HQ8A 1IW4A 1NUBA 1OYVI 1XA6A 2QPOA 3UEJA 1Y1BA 3B4VC 1N13A 2V1CA 5E3PA 2P6AC 1UVGA 1AN1I 2XRCA 1PPFI 2NU2I 1TIHA 5HI7A 1MT1A 1HPTA 5EX3A 3KY9A 5DAEA 1PCEA 1W3SA 2DIPA 2ORWA 2YUUA 1YU6C 3PDNA 3FSXA 1TBQR 3QAHA 5J8FA 1H0ZA 1V1HA 2QQDA 2SGPI 1FYBA 1Z2IA 2LUYA 3OVOA 1SGEI 3CXLA 3SGQI 1FAQA 2JW6A 2K9HA 1HJAI 2PQ8A 1CGJI 3TO6A 3MEKA 1TBNA 3BJIA 5FUWA 4UXIA 2WGCA 3QTLD 2ARPF 2FNFX 3R5BA 4SGBI 2YQPA 5J8CA 1FARA 2WVJA 1KBEA 3HH2C 4MPIA 3UEYA 4L9MA 1MJBA 2JZMA 2VRWB 4WP4A 3TO9A 1ULMA 2L8EA 3VDUA 4A24A 2GKRI 3R5AA 1U5KA 2ERWA 1W4RA 2GIVA 2GKTI 1CT4I 1DS3I 1CE3A 5JHWC 1HEVA 1MJ9A 2X3TA 1FY7A 1YTPA 5EX0A 3UGLA 1TBOA 1Q9BA 1V1IA 2ENZA 2GKVA 1K7TA 2JYYA 2KMRA 2UZ3A 2QQ0A 3TOAA 1TUSA 1Y8FA 5E3QA 2OVOA 3FSYA 1TOTA 2M5XA 2Y0MA 3E59A 2SGEI 2A20A 3SGBI 4FKDA 1MJAA 1UHAA 1Z7KB 2JA1A 2W0TA 1RFHA 3OXLA 2E73A 2ENNA 2NU1I 2OU2A 4HGUA 1KBFA 1PJUA 2E5RA 2SGFI 2RC4A 1UUCA 4JCVE 4UXJA 3GOXA 9WGAA 1BUSA 2LB7A 2NU4I 2BUSA 1R79A 2CWGA 1R0RI 2DB6A
chains in the Genus database with same CATH topology
2J87A 5FUYA 4GI3C 1TURA 1UVFA 1SGQI 2J9RA 3VE5A 1LR9A 1XX6A 1VDDA 3UFFA 3RU0A 2ELIA 4E1PA 2NU0I 1TBRR 2KCXA 2N71A 1KMAA 3OL0A 1TGSI 2JXDA 2KMPA 2LEOA 2QQEA 2SGDI 2OD1A 4B6DA 2QQCA 2NU3I 3SEKC 1LR8A 2SGQI 2ODDA 1OMTA 1M8CA 2N1AB 2GVIA 1OVOA 1SGRI 2B8TA 2N52A 3UGIA 1HDLA 2CJSC 2ORVA 3D00A 1LR7A 1IY6A 2N17A 3TJQA 1SGDI 4E1RA 2B0UC 5FUVA 3FC3A 1OMUA 1M8BA 1CSOI 1CT0I 1BMOA 1DS2I 2KMOA 1PTRA 1XBTA 3E2IA 2ROWA 2WCYA 2V1CC 1X4SA 4OVOA 3UGDA 1PTQA 4UXHA 3OXGA 5FUXA 5CCMA 1IY5A 3VDPA 1CGII 1Y1CA 5CCLA 2V53A 1X74A 2KMQA 1SGPI 1CHOI 1SGYI 1SGNI 2F3CI 2L7XA 3OXFA 1CT2I 3QWPA 5HQ8A 1IW4A 1NUBA 1OYVI 1XA6A 2QPOA 3UEJA 1Y1BA 3B4VC 1N13A 2V1CA 2P6AC 1UVGA 1AN1I 2XRCA 1PPFI 2NU2I 1TIHA 5HI7A 1MT1A 1HPTA 5EX3A 3KY9A 5DAEA 1PCEA 1W3SA 2DIPA 2ORWA 2YUUA 1YU6C 3PDNA 1H0ZA 1TBQR 1V1HA 2QQDA 2SGPI 1FYBA 2LUYA 3OVOA 1SGEI 3CXLA 3SGQI 1FAQA 2JW6A 2K9HA 1HJAI 1CGJI 3MEKA 1TBNA 3BJIA 5FUWA 4UXIA 3QTLD 4SGBI 2ARPF 2FNFX 2YQPA 1FARA 2WVJA 1KBEA 3HH2C 3UEYA 4L9MA 2JZMA 2VRWB 4A24A 3VDUA 2L8EA 2GKRI 1U5KA 2ERWA 1W4RA 2GKTI 1CT4I 1DS3I 1CE3A 5JHWC 1YTPA 5EX0A 3UGLA 1TBOA 1V1IA 2ENZA 2GKVA 2JYYA 2KMRA 2UZ3A 2QQ0A 1TUSA 1Y8FA 2OVOA 1TOTA 2M5XA 3E59A 2SGEI 2A20A 3SGBI 4FKDA 1Z7KB 2JA1A 2W0TA 1RFHA 3OXLA 2E73A 2ENNA 2NU1I 4HGUA 1KBFA 1PJUA 2E5RA 2SGFI 1UUCA 4JCVE 4UXJA 3GOXA 1BUSA 2NU4I 2BUSA 1R79A 1R0RI 2DB6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GI3 C;  1TUR A;  1UVF A;  1SGQ I;  1LR9 A;  2NU0 I;  1TBR R;  2KCX A;  2N71 A;  1KMA A;  1TGS I;  2JXD A;  2KMP A;  2LEO A;  2SGD I;  2QQC A;  2NU3 I;  3SEK C;  1LR8 A;  2SGQ I;  1OMT A;  1M8C A;  1OVO A;  1SGR I;  2N52 A;  1HDL A;  1LR7 A;  1IY6 A;  2N17 A;  3TJQ A;  1SGD I;  2B0U C;  1OMU A;  1M8B A;  1CSO I;  1CT0 I;  1BMO A;  1DS2 I;  2KMO A;  2WCY A;  4OVO A;  1IY5 A;  1CGI I;  1Y1C A;  2V53 A;  1SGP I;  1CHO I;  1SGY I;  1SGN I;  2F3C I;  1CT2 I;  1IW4 A;  1NUB A;  1OYV I;  1Y1B A;  3B4V C;  1N13 A;  2P6A C;  1UVG A;  1AN1 I;  2XRC A;  1PPF I;  2NU2 I;  1TIH A;  1MT1 A;  1HPT A;  5DAE A;  1PCE A;  1YU6 C;  1H0Z A;  1TBQ R;  2QQD A;  2SGP I;  1FYB A;  3OVO A;  1SGE I;  3SGQ I;  1HJA I;  1CGJ I;  3QTL D;  4SGB I;  2ARP F;  3HH2 C;  2JZM A;  2GKR I;  2ERW A;  2GKT I;  1CT4 I;  1DS3 I;  1CE3 A;  5JHW C;  1YTP A;  2GKV A;  2JYY A;  2KMR A;  1TUS A;  2OVO A;  2M5X A;  2SGE I;  3SGB I;  1Z7K B;  2NU1 I;  4HGU A;  1PJU A;  2SGF I;  1UUC A;  1BUS A;  2NU4 I;  2BUS A;  2KMQ A;  1R0R I; 
#chains in the Genus database with same CATH topology
 2J87 A;  3UOE A;  5FUY A;  4GI3 C;  1WGC A;  1WGT A;  3R5D A;  1TUR A;  1UVF A;  1SGQ I;  2J9R A;  2DKV A;  3VE5 A;  2OZU A;  2RIJ A;  1LR9 A;  1WKX A;  1K7U A;  1XX6 A;  1VDD A;  3UFF A;  3RU0 A;  4AML A;  2ELI A;  4E1P A;  2NU0 I;  1TBR R;  2CWH A;  2KCX A;  2N71 A;  3OL0 A;  1KMA A;  1TGS I;  2JXD A;  2KMP A;  2LEO A;  2QQE A;  2SGD I;  2OD1 A;  3TOB A;  4B6D A;  2QQC A;  2NU3 I;  3R5C A;  3SEK C;  1LR8 A;  1P9G A;  2ODD A;  2SGQ I;  1OMT A;  1M8C A;  2N1A B;  2GVI A;  1OVO A;  1SGR I;  2B8T A;  2N52 A;  3UGI A;  1HDL A;  2CJS C;  2CWF A;  2ORV A;  3D00 A;  1LR7 A;  1IY6 A;  2N17 A;  3TJQ A;  1SGD I;  4E1R A;  2B0U C;  5FUV A;  3FC3 A;  1OMU A;  1M8B A;  1CSO I;  1CT0 I;  1BMO A;  1DS2 I;  2KMO A;  1PTR A;  7WGA A;  1XBT A;  3E2I A;  4DNC A;  2ROW A;  2UVO A;  3TO7 A;  2WCY A;  2V1C C;  1X4S A;  4OVO A;  3UGD A;  1ULK A;  1PTQ A;  1P9Z A;  1ULN A;  4UXH A;  3OXG A;  5FUX A;  5CCM A;  1IY5 A;  1NXU A;  3VDP A;  1K7V A;  1CGI I;  1Y1C A;  5CCL A;  2V53 A;  1S20 A;  1X74 A;  2KMQ A;  5E3R A;  1SGP I;  1CHO I;  1SGY I;  1SGN I;  2F3C I;  2X52 A;  2L7X A;  3OXF A;  1CT2 I;  1WTJ A;  3QWP A;  5HQ8 A;  1IW4 A;  1NUB A;  1OYV I;  1XA6 A;  2QPO A;  3UEJ A;  1Y1B A;  3B4V C;  1N13 A;  2V1C A;  5E3P A;  2P6A C;  1UVG A;  1AN1 I;  2XRC A;  1PPF I;  2NU2 I;  1TIH A;  5HI7 A;  1MT1 A;  1HPT A;  5EX3 A;  3KY9 A;  5DAE A;  1PCE A;  1W3S A;  2DIP A;  2ORW A;  2YUU A;  1YU6 C;  3PDN A;  3FSX A;  1TBQ R;  3QAH A;  5J8F A;  1H0Z A;  1V1H A;  2QQD A;  2SGP I;  1FYB A;  1Z2I A;  2LUY A;  3OVO A;  1SGE I;  3CXL A;  3SGQ I;  1FAQ A;  2JW6 A;  2K9H A;  1HJA I;  2PQ8 A;  1CGJ I;  3TO6 A;  3MEK A;  1TBN A;  3BJI A;  5FUW A;  4UXI A;  2WGC A;  3QTL D;  2ARP F;  2FNF X;  3R5B A;  4SGB I;  2YQP A;  5J8C A;  1FAR A;  2WVJ A;  1KBE A;  3HH2 C;  4MPI A;  3UEY A;  4L9M A;  1MJB A;  2JZM A;  2VRW B;  4WP4 A;  3TO9 A;  1ULM A;  2L8E A;  3VDU A;  4A24 A;  2GKR I;  3R5A A;  1U5K A;  2ERW A;  1W4R A;  2GIV A;  2GKT I;  1CT4 I;  1DS3 I;  1CE3 A;  5JHW C;  1HEV A;  1MJ9 A;  2X3T A;  1FY7 A;  1YTP A;  5EX0 A;  3UGL A;  1TBO A;  1Q9B A;  1V1I A;  2ENZ A;  2GKV A;  1K7T A;  2JYY A;  2KMR A;  2UZ3 A;  2QQ0 A;  3TOA A;  1TUS A;  1Y8F A;  5E3Q A;  2OVO A;  3FSY A;  1TOT A;  2M5X A;  2Y0M A;  3E59 A;  2SGE I;  2A20 A;  3SGB I;  4FKD A;  1MJA A;  1UHA A;  1Z7K B;  2JA1 A;  2W0T A;  1RFH A;  3OXL A;  2E73 A;  2ENN A;  2NU1 I;  2OU2 A;  4HGU A;  1KBF A;  1PJU A;  2E5R A;  2SGF I;  2RC4 A;  1UUC A;  4JCV E;  4UXJ A;  3GOX A;  9WGA A;  1BUS A;  2LB7 A;  2NU4 I;  2BUS A;  1R79 A;  2CWG A;  1R0R I;  2DB6 A; 
#chains in the Genus database with same CATH homology
 2J87 A;  5FUY A;  4GI3 C;  1TUR A;  1UVF A;  1SGQ I;  2J9R A;  3VE5 A;  1LR9 A;  1XX6 A;  1VDD A;  3UFF A;  3RU0 A;  2ELI A;  4E1P A;  2NU0 I;  1TBR R;  2KCX A;  2N71 A;  1KMA A;  3OL0 A;  1TGS I;  2JXD A;  2KMP A;  2LEO A;  2QQE A;  2SGD I;  2OD1 A;  4B6D A;  2QQC A;  2NU3 I;  3SEK C;  1LR8 A;  2SGQ I;  2ODD A;  1OMT A;  1M8C A;  2N1A B;  2GVI A;  1OVO A;  1SGR I;  2B8T A;  2N52 A;  3UGI A;  1HDL A;  2CJS C;  2ORV A;  3D00 A;  1LR7 A;  1IY6 A;  2N17 A;  3TJQ A;  1SGD I;  4E1R A;  2B0U C;  5FUV A;  3FC3 A;  1OMU A;  1M8B A;  1CSO I;  1CT0 I;  1BMO A;  1DS2 I;  2KMO A;  1PTR A;  1XBT A;  3E2I A;  2ROW A;  2WCY A;  2V1C C;  1X4S A;  4OVO A;  3UGD A;  1PTQ A;  4UXH A;  3OXG A;  5FUX A;  5CCM A;  1IY5 A;  3VDP A;  1CGI I;  1Y1C A;  5CCL A;  2V53 A;  1X74 A;  2KMQ A;  1SGP I;  1CHO I;  1SGY I;  1SGN I;  2F3C I;  2L7X A;  3OXF A;  1CT2 I;  3QWP A;  5HQ8 A;  1IW4 A;  1NUB A;  1OYV I;  1XA6 A;  2QPO A;  3UEJ A;  1Y1B A;  3B4V C;  1N13 A;  2V1C A;  2P6A C;  1UVG A;  1AN1 I;  2XRC A;  1PPF I;  2NU2 I;  1TIH A;  5HI7 A;  1MT1 A;  1HPT A;  5EX3 A;  3KY9 A;  5DAE A;  1PCE A;  1W3S A;  2DIP A;  2ORW A;  2YUU A;  1YU6 C;  3PDN A;  1H0Z A;  1TBQ R;  1V1H A;  2QQD A;  2SGP I;  1FYB A;  2LUY A;  3OVO A;  1SGE I;  3CXL A;  3SGQ I;  1FAQ A;  2JW6 A;  2K9H A;  1HJA I;  1CGJ I;  3MEK A;  1TBN A;  3BJI A;  5FUW A;  4UXI A;  3QTL D;  4SGB I;  2ARP F;  2FNF X;  2YQP A;  1FAR A;  2WVJ A;  1KBE A;  3HH2 C;  3UEY A;  4L9M A;  2JZM A;  2VRW B;  4A24 A;  3VDU A;  2L8E A;  2GKR I;  1U5K A;  2ERW A;  1W4R A;  2GKT I;  1CT4 I;  1DS3 I;  1CE3 A;  5JHW C;  1YTP A;  5EX0 A;  3UGL A;  1TBO A;  1V1I A;  2ENZ A;  2GKV A;  2JYY A;  2KMR A;  2UZ3 A;  2QQ0 A;  1TUS A;  1Y8F A;  2OVO A;  1TOT A;  2M5X A;  3E59 A;  2SGE I;  2A20 A;  3SGB I;  4FKD A;  1Z7K B;  2JA1 A;  2W0T A;  1RFH A;  3OXL A;  2E73 A;  2ENN A;  2NU1 I;  4HGU A;  1KBF A;  1PJU A;  2E5R A;  2SGF I;  1UUC A;  4JCV E;  4UXJ A;  3GOX A;  1BUS A;  2NU4 I;  2BUS A;  1R79 A;  1R0R I;  2DB6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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