4GI3C

Crystal structure of greglin in complex with subtilisin
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
57
structure length
57
Chain Sequence
CPSICPLIYAPVCVEDSNQDFYLFVNECEVRKCGCEAGFVYTFVPREMCKATTSLCP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of greglin, a novel non-classical Kazal inhibitor, in complex with subtilisin
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords KerA
total genus 8
structure length 57
sequence length 57
ec nomenclature
pdb deposition date 2012-08-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 4gi3C00
3B4VC 2KMRA 2M5XA 1HPTA 1LR9A 1Y1CA 2BUSA 4OVOA 1LR8A 2KCXA 1PJUA 2KMPA 2GKTI 1PCEA 2XRCA 1OMTA 2JZMA 1CHOI 1CGII 1IY5A 1OMUA 1HJAI 2OVOA 1BUSA 1KMAA 1M8CA 3TJQA 2F3CI 2SGDI 2KMOA 1H0ZA 2NU1I 1DS2I 1SGQI 2SGPI 1R0RI 2N71A 1CT2I 1SGNI 1TUSA 1UVFA 1TBQR 2JXDA 1Z7KB 1FYBA 2NU4I 1HDLA 2SGFI 1UVGA 2V53A 2NU2I 1TGSI 1DS3I 1Y1BA 2GKRI 1SGPI 1YU6C 2ARPF 2NU0I 4GI3C 2SGQI 2KMQA 4HGUA 2JYYA 1IW4A 2P6AC 1NUBA 1SGRI 2QQDA 1OYVI 1IY6A 2N52A 4SGBI 2NU3I 1M8BA 2B0UC 1LR7A 2GKVA 3SGBI 1PPFI 5DAEA 1CT0I 3OVOA 1CT4I 2WCYA 2SGEI 3SEKC 1BMOA 2N17A 3SGQI 2QQCA 1AN1I 3HH2C 5JHWC 1TURA 1SGYI 1SGDI 1N13A 1MT1A 1TIHA 2ERWA 3QTLD 1OVOA 1CE3A 1SGEI 1CGJI 1UUCA 2LEOA 1CSOI 1YTPA 1TBRR
chains in the Genus database with same CATH superfamily
2JA1A 5E3RA 1V1IA 3R5CA 1FARA 3B4VC 1WGCA 2KMRA 1K7VA 3CXLA 2M5XA 2ORWA 4AMLA 2LUYA 2A20A 2QPOA 3FSXA 1HPTA 2CJSC 1LR9A 1Y1CA 5EX3A 2BUSA 1U5KA 4OVOA 3FSYA 1LR8A 3GOXA 1P9ZA 1CSOI 2KCXA 5FUXA 1PJUA 3FC3A 5HI7A 2W0TA 2ORVA 2KMPA 2GKTI 1PCEA 2XRCA 2B8TA 2QQ0A 4WP4A 1KBEA 1FY7A 1OMTA 2JZMA 1WKXA 1CHOI 1CGII 2PQ8A 3MEKA 1OMUA 1IY5A 1CE3A 1UHAA 1HJAI 2OVOA 2RC4A 2WVJA 1R79A 3KY9A 1BUSA 1KMAA 1M8CA 3TJQA 1X4SA 2J9RA 1TBNA 2F3CI 2SGDI 3QWPA 4L9MA 1ULNA 3OL0A 1PTRA 2Y0MA 5E3PA 1X74A 2ENZA 1KBFA 4B6DA 2KMOA 1ULKA 1H0ZA 2NU1I 1DS2I 1SGQI 1Z2IA 2E73A 1R0RI 2N71A 2SGPI 1MJAA 1CT2I 2CWGA 1SGNI 3R5DA 1TUSA 1UVFA 1TBQR 2LB7A 2YUUA 4UXIA 3VDUA 2JXDA 4E1RA 5CCLA 1Z7KB 2ODDA 2OZUA 4UXHA 3VE5A 3TO6A 1FYBA 5E3QA 2NU4I 1HDLA 2SGFI 1UVGA 2V53A 1MJ9A 2V1CA 2NU2I 1TGSI 2X52A 1DS3I 1Y1BA 2GKRI 1SGPI 3OXGA 1YU6C 2X3TA 4JCVE 2ARPF 3QAHA 1XX6A 4A24A 3E2IA 1RFHA 1XA6A 2N1AB 2NU0I 4GI3C 2SGQI 2KMQA 1WTJA 2L8EA 3UGIA 4HGUA 3UGDA 3VDPA 2DKVA 5FUVA 1TBOA 1S20A 2JYYA 3UOEA 5J8FA 5FUWA 2J87A 1NXUA 2E5RA 3UEJA 4DNCA 2ROWA 3D00A 2P6AC 1W3SA 1NUBA 1SGRI 1OYVI 2QQEA 2QQDA 7WGAA 3BJIA 1IY6A 1WGTA 1XBTA 3UEYA 2DB6A 2CWHA 2JW6A 4FKDA 2DIPA 3UFFA 2ELIA 2N52A 3OXFA 5J8CA 3TOAA 4SGBI 4E1PA 2NU3I 3R5BA 4UXJA 1M8BA 2B0UC 1LR7A 2GKVA 3OXLA 1PTQA 3SGBI 1VDDA 1PPFI 2YQPA 2OU2A 3TO7A 3TOBA 5DAEA 1CT0I 3OVOA 3UGLA 1MJBA 2GIVA 1CT4I 2WCYA 2SGEI 3RU0A 5FUYA 2FNFX 3SEKC 4MPIA 5EX0A 1V1HA 1Q9BA 1ULMA 1BMOA 2L7XA 2N17A 2WGCA 5CCMA 1FAQA 3SGQI 9WGAA 2K9HA 2QQCA 1AN1I 2GVIA 3HH2C 3TO9A 1TOTA 1SGYI 1SGDI 1TURA 1N13A 1Y8FA 3PDNA 2UVOA 5JHWC 1HEVA 1MT1A 1TIHA 2ERWA 2UZ3A 3QTLD 2VRWB 1OVOA 1W4RA 2RIJA 1SGEI 1CGJI 1K7TA 1UUCA 2ENNA 1IW4A 1P9GA 2LEOA 5HQ8A 2CWFA 2OD1A 2V1CC 1K7UA 3R5AA 1YTPA 3E59A 1TBRR
chains in the Genus database with same CATH topology
2JA1A 1V1IA 1FARA 3B4VC 2KMRA 3CXLA 2M5XA 2ORWA 2LUYA 2A20A 2QPOA 1HPTA 2CJSC 1LR9A 1Y1CA 5EX3A 2BUSA 1U5KA 4OVOA 3GOXA 1LR8A 2KCXA 5FUXA 1PJUA 3FC3A 5HI7A 2W0TA 2ORVA 2KMPA 2GKTI 1PCEA 2XRCA 2B8TA 2QQ0A 1KBEA 1OMTA 2JZMA 1CHOI 1CGII 3MEKA 1IY5A 1OMUA 1HJAI 2OVOA 2WVJA 1R79A 3KY9A 1BUSA 1KMAA 1M8CA 3TJQA 1X4SA 2J9RA 1TBNA 2F3CI 2SGDI 3QWPA 4L9MA 3OL0A 1PTRA 1X74A 2ENZA 1KBFA 4B6DA 2KMOA 1H0ZA 2NU1I 1DS2I 1SGQI 2E73A 1R0RI 2N71A 2SGPI 1CT2I 1SGNI 1TUSA 1UVFA 1TBQR 2YUUA 4UXIA 3VDUA 2JXDA 4E1RA 5CCLA 1Z7KB 2ODDA 3VE5A 4UXHA 1FYBA 2NU4I 1HDLA 2SGFI 1UVGA 2V53A 2V1CA 2NU2I 1TGSI 1DS3I 1Y1BA 2GKRI 1SGPI 3OXGA 1YU6C 4JCVE 2ARPF 1XX6A 4A24A 3E2IA 1RFHA 1XA6A 2N1AB 2NU0I 4GI3C 2SGQI 2KMQA 2L8EA 3UGIA 4HGUA 3UGDA 3VDPA 5FUVA 1TBOA 2JYYA 5FUWA 2J87A 2E5RA 3UEJA 1IW4A 2ROWA 3D00A 2P6AC 1NUBA 1SGRI 1W3SA 1OYVI 2QQEA 2QQDA 1IY6A 3BJIA 1XBTA 3UEYA 2DB6A 2JW6A 4FKDA 2DIPA 3UFFA 2ELIA 2N52A 3OXFA 4SGBI 4E1PA 2NU3I 4UXJA 1M8BA 2B0UC 1LR7A 2GKVA 3OXLA 1PTQA 3SGBI 1VDDA 1PPFI 2YQPA 5DAEA 1CT0I 3OVOA 3UGLA 1CT4I 2WCYA 2SGEI 3RU0A 5FUYA 2FNFX 3SEKC 5EX0A 1V1HA 2L7XA 1BMOA 2N17A 5CCMA 1FAQA 3SGQI 2K9HA 2QQCA 1AN1I 2GVIA 3HH2C 5JHWC 1TOTA 1SGYI 1SGDI 1TURA 1N13A 1Y8FA 3PDNA 1MT1A 1TIHA 2ERWA 2UZ3A 3QTLD 2VRWB 1OVOA 1W4RA 1CE3A 1SGEI 1CGJI 1UUCA 2ENNA 2LEOA 5HQ8A 2OD1A 2V1CC 1CSOI 1YTPA 3E59A 1TBRR
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3B4V C;  2KMR A;  2M5X A;  1HPT A;  1LR9 A;  1Y1C A;  2BUS A;  4OVO A;  1LR8 A;  2KCX A;  1PJU A;  2KMP A;  2GKT I;  1PCE A;  2XRC A;  1OMT A;  2JZM A;  1CHO I;  1CGI I;  1IY5 A;  1OMU A;  1HJA I;  2OVO A;  1BUS A;  1KMA A;  1M8C A;  3TJQ A;  2F3C I;  2SGD I;  2KMO A;  1H0Z A;  2NU1 I;  1DS2 I;  1SGQ I;  2SGP I;  1R0R I;  2N71 A;  1CT2 I;  1SGN I;  1TUS A;  1UVF A;  1TBQ R;  2JXD A;  1Z7K B;  1FYB A;  2NU4 I;  1HDL A;  2SGF I;  1UVG A;  2V53 A;  2NU2 I;  1TGS I;  1DS3 I;  1Y1B A;  2GKR I;  1SGP I;  1YU6 C;  2ARP F;  2NU0 I;  4GI3 C;  2SGQ I;  2KMQ A;  4HGU A;  2JYY A;  1IW4 A;  2P6A C;  1NUB A;  1SGR I;  2QQD A;  1OYV I;  1IY6 A;  2N52 A;  4SGB I;  2NU3 I;  1M8B A;  2B0U C;  1LR7 A;  2GKV A;  3SGB I;  1PPF I;  5DAE A;  1CT0 I;  3OVO A;  1CT4 I;  2WCY A;  2SGE I;  3SEK C;  1BMO A;  2N17 A;  3SGQ I;  2QQC A;  1AN1 I;  3HH2 C;  5JHW C;  1TUR A;  1SGY I;  1SGD I;  1N13 A;  1MT1 A;  1TIH A;  2ERW A;  3QTL D;  1OVO A;  1CE3 A;  1SGE I;  1CGJ I;  1UUC A;  2LEO A;  1CSO I;  1YTP A;  1TBR R; 
#chains in the Genus database with same CATH topology
 2JA1 A;  5E3R A;  1V1I A;  3R5C A;  1FAR A;  3B4V C;  1WGC A;  2KMR A;  1K7V A;  3CXL A;  2M5X A;  2ORW A;  4AML A;  2LUY A;  2A20 A;  2QPO A;  3FSX A;  1HPT A;  2CJS C;  1LR9 A;  1Y1C A;  5EX3 A;  2BUS A;  1U5K A;  4OVO A;  3FSY A;  1LR8 A;  3GOX A;  1P9Z A;  1CSO I;  2KCX A;  5FUX A;  1PJU A;  3FC3 A;  5HI7 A;  2W0T A;  2ORV A;  2KMP A;  2GKT I;  1PCE A;  2XRC A;  2B8T A;  2QQ0 A;  4WP4 A;  1KBE A;  1FY7 A;  1OMT A;  2JZM A;  1WKX A;  1CHO I;  1CGI I;  2PQ8 A;  3MEK A;  1OMU A;  1IY5 A;  1CE3 A;  1UHA A;  1HJA I;  2OVO A;  2RC4 A;  2WVJ A;  1R79 A;  3KY9 A;  1BUS A;  1KMA A;  1M8C A;  3TJQ A;  1X4S A;  2J9R A;  1TBN A;  2F3C I;  2SGD I;  3QWP A;  4L9M A;  1ULN A;  3OL0 A;  1PTR A;  2Y0M A;  5E3P A;  1X74 A;  2ENZ A;  1KBF A;  4B6D A;  2KMO A;  1ULK A;  1H0Z A;  2NU1 I;  1DS2 I;  1SGQ I;  1Z2I A;  2E73 A;  1R0R I;  2N71 A;  2SGP I;  1MJA A;  1CT2 I;  2CWG A;  1SGN I;  3R5D A;  1TUS A;  1UVF A;  1TBQ R;  2LB7 A;  2YUU A;  4UXI A;  3VDU A;  2JXD A;  4E1R A;  5CCL A;  1Z7K B;  2ODD A;  2OZU A;  4UXH A;  3VE5 A;  3TO6 A;  1FYB A;  5E3Q A;  2NU4 I;  1HDL A;  2SGF I;  1UVG A;  2V53 A;  1MJ9 A;  2V1C A;  2NU2 I;  1TGS I;  2X52 A;  1DS3 I;  1Y1B A;  2GKR I;  1SGP I;  3OXG A;  1YU6 C;  2X3T A;  4JCV E;  2ARP F;  3QAH A;  1XX6 A;  4A24 A;  3E2I A;  1RFH A;  1XA6 A;  2N1A B;  2NU0 I;  4GI3 C;  2SGQ I;  2KMQ A;  1WTJ A;  2L8E A;  3UGI A;  4HGU A;  3UGD A;  3VDP A;  2DKV A;  5FUV A;  1TBO A;  1S20 A;  2JYY A;  3UOE A;  5J8F A;  5FUW A;  2J87 A;  1NXU A;  2E5R A;  3UEJ A;  4DNC A;  2ROW A;  3D00 A;  2P6A C;  1W3S A;  1NUB A;  1SGR I;  1OYV I;  2QQE A;  2QQD A;  7WGA A;  3BJI A;  1IY6 A;  1WGT A;  1XBT A;  3UEY A;  2DB6 A;  2CWH A;  2JW6 A;  4FKD A;  2DIP A;  3UFF A;  2ELI A;  2N52 A;  3OXF A;  5J8C A;  3TOA A;  4SGB I;  4E1P A;  2NU3 I;  3R5B A;  4UXJ A;  1M8B A;  2B0U C;  1LR7 A;  2GKV A;  3OXL A;  1PTQ A;  3SGB I;  1VDD A;  1PPF I;  2YQP A;  2OU2 A;  3TO7 A;  3TOB A;  5DAE A;  1CT0 I;  3OVO A;  3UGL A;  1MJB A;  2GIV A;  1CT4 I;  2WCY A;  2SGE I;  3RU0 A;  5FUY A;  2FNF X;  3SEK C;  4MPI A;  5EX0 A;  1V1H A;  1Q9B A;  1ULM A;  1BMO A;  2L7X A;  2N17 A;  2WGC A;  5CCM A;  1FAQ A;  3SGQ I;  9WGA A;  2K9H A;  2QQC A;  1AN1 I;  2GVI A;  3HH2 C;  3TO9 A;  1TOT A;  1SGY I;  1SGD I;  1TUR A;  1N13 A;  1Y8F A;  3PDN A;  2UVO A;  5JHW C;  1HEV A;  1MT1 A;  1TIH A;  2ERW A;  2UZ3 A;  3QTL D;  2VRW B;  1OVO A;  1W4R A;  2RIJ A;  1SGE I;  1CGJ I;  1K7T A;  1UUC A;  2ENN A;  1IW4 A;  1P9G A;  2LEO A;  5HQ8 A;  2CWF A;  2OD1 A;  2V1C C;  1K7U A;  3R5A A;  1YTP A;  3E59 A;  1TBR R; 
#chains in the Genus database with same CATH homology
 2JA1 A;  1V1I A;  1FAR A;  3B4V C;  2KMR A;  3CXL A;  2M5X A;  2ORW A;  2LUY A;  2A20 A;  2QPO A;  1HPT A;  2CJS C;  1LR9 A;  1Y1C A;  5EX3 A;  2BUS A;  1U5K A;  4OVO A;  3GOX A;  1LR8 A;  2KCX A;  5FUX A;  1PJU A;  3FC3 A;  5HI7 A;  2W0T A;  2ORV A;  2KMP A;  2GKT I;  1PCE A;  2XRC A;  2B8T A;  2QQ0 A;  1KBE A;  1OMT A;  2JZM A;  1CHO I;  1CGI I;  3MEK A;  1IY5 A;  1OMU A;  1HJA I;  2OVO A;  2WVJ A;  1R79 A;  3KY9 A;  1BUS A;  1KMA A;  1M8C A;  3TJQ A;  1X4S A;  2J9R A;  1TBN A;  2F3C I;  2SGD I;  3QWP A;  4L9M A;  3OL0 A;  1PTR A;  1X74 A;  2ENZ A;  1KBF A;  4B6D A;  2KMO A;  1H0Z A;  2NU1 I;  1DS2 I;  1SGQ I;  2E73 A;  1R0R I;  2N71 A;  2SGP I;  1CT2 I;  1SGN I;  1TUS A;  1UVF A;  1TBQ R;  2YUU A;  4UXI A;  3VDU A;  2JXD A;  4E1R A;  5CCL A;  1Z7K B;  2ODD A;  3VE5 A;  4UXH A;  1FYB A;  2NU4 I;  1HDL A;  2SGF I;  1UVG A;  2V53 A;  2V1C A;  2NU2 I;  1TGS I;  1DS3 I;  1Y1B A;  2GKR I;  1SGP I;  3OXG A;  1YU6 C;  4JCV E;  2ARP F;  1XX6 A;  4A24 A;  3E2I A;  1RFH A;  1XA6 A;  2N1A B;  2NU0 I;  4GI3 C;  2SGQ I;  2KMQ A;  2L8E A;  3UGI A;  4HGU A;  3UGD A;  3VDP A;  5FUV A;  1TBO A;  2JYY A;  5FUW A;  2J87 A;  2E5R A;  3UEJ A;  1IW4 A;  2ROW A;  3D00 A;  2P6A C;  1NUB A;  1SGR I;  1W3S A;  1OYV I;  2QQE A;  2QQD A;  1IY6 A;  3BJI A;  1XBT A;  3UEY A;  2DB6 A;  2JW6 A;  4FKD A;  2DIP A;  3UFF A;  2ELI A;  2N52 A;  3OXF A;  4SGB I;  4E1P A;  2NU3 I;  4UXJ A;  1M8B A;  2B0U C;  1LR7 A;  2GKV A;  3OXL A;  1PTQ A;  3SGB I;  1VDD A;  1PPF I;  2YQP A;  5DAE A;  1CT0 I;  3OVO A;  3UGL A;  1CT4 I;  2WCY A;  2SGE I;  3RU0 A;  5FUY A;  2FNF X;  3SEK C;  5EX0 A;  1V1H A;  2L7X A;  1BMO A;  2N17 A;  5CCM A;  1FAQ A;  3SGQ I;  2K9H A;  2QQC A;  1AN1 I;  2GVI A;  3HH2 C;  5JHW C;  1TOT A;  1SGY I;  1SGD I;  1TUR A;  1N13 A;  1Y8F A;  3PDN A;  1MT1 A;  1TIH A;  2ERW A;  2UZ3 A;  3QTL D;  2VRW B;  1OVO A;  1W4R A;  1CE3 A;  1SGE I;  1CGJ I;  1UUC A;  2ENN A;  2LEO A;  5HQ8 A;  2OD1 A;  2V1C C;  1CSO I;  1YTP A;  3E59 A;  1TBR R; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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