2KMOA

Solution structure of native leech-derived tryptase inhibitor, ldti
Total Genus 6
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
6
sequence length
44
structure length
44
Chain Sequence
KKVCACPKILKPVCGSDGRTYANSCIARCNGVSIKSEGSCPTGI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Leech-derived tryptase inhibitor C
publication title Deciphering the structural basis that guides the oxidative folding of leech-derived tryptase inhibitor.
pubmed doi rcsb
source organism Hirudo medicinalis
molecule tags Hydrolase
total genus 6
structure length 44
sequence length 44
ec nomenclature
pdb deposition date 2009-08-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00050 Kazal_1 Kazal-type serine protease inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 2kmoA00
1UVFA 2M5XA 2SGDI 1M8BA 2P6AC 2GKTI 1SGNI 1LR7A 1N13A 1Y1CA 2NU2I 1OMUA 2BUSA 2NU1I 1TGSI 1SGPI 1UUCA 3HH2C 1LR9A 2LEOA 1OMTA 2XRCA 1SGDI 2GKVA 1IY5A 2N52A 3B4VC 4OVOA 1DS3I 1Z7KB 2NU3I 1FYBA 1OVOA 1TIHA 1TBRR 1SGQI 2V53A 1UVGA 1NUBA 1R0RI 2N71A 5JHWC 1CSOI 1CE3A 1CGJI 2QQCA 2SGPI 3SEKC 2SGFI 1PPFI 1YTPA 4GI3C 2KMQA 1H0ZA 1Y1BA 1PCEA 1OYVI 2ERWA 2KCXA 2B0UC 3TJQA 1TUSA 3SGBI 1M8CA 1HDLA 3QTLD 2KMPA 1TURA 1CT2I 1BUSA 4HGUA 5DAEA 2ARPF 1HPTA 1MT1A 2JXDA 1KMAA 2NU4I 1CT0I 1AN1I 2SGQI 1BMOA 1CGII 2WCYA 2N17A 1SGYI 1CT4I 3SGQI 4SGBI 1SGRI 1PJUA 2NU0I 2JYYA 1HJAI 2OVOA 2JZMA 1DS2I 2GKRI 2F3CI 2SGEI 1IW4A 2QQDA 1TBQR 3OVOA 1YU6C 1SGEI 1LR8A 2KMOA 1CHOI 2KMRA 1IY6A
chains in the Genus database with same CATH superfamily
1UVFA 2E5RA 2M5XA 3QWPA 2SGDI 1M8BA 2P6AC 4UXHA 1VDDA 2GKTI 2X52A 2QQ0A 1SGNI 1LR7A 1R79A 1Y8FA 1ULMA 3OL0A 4A24A 2QQEA 2X3TA 3UGIA 1N13A 4AMLA 1RFHA 1Y1CA 3TOBA 2NU2I 3R5DA 1OMUA 5FUYA 2BUSA 2NU1I 2UZ3A 2J9RA 1Q9BA 3D00A 1TGSI 1X4SA 2JW6A 3QAHA 3UEYA 3UFFA 1TBOA 1XBTA 2W0TA 5E3RA 1SGPI 1UUCA 2ORWA 2GVIA 3HH2C 1LR9A 2LEOA 2OZUA 1MJ9A 1OMTA 4FKDA 4B6DA 2XRCA 4DNCA 5J8FA 3VE5A 1SGDI 3OXLA 1XA6A 2GKVA 1W3SA 1TOTA 1IY5A 1S20A 2N52A 3E2IA 3B4VC 4OVOA 2DKVA 1DS3I 1U5KA 1XX6A 1WTJA 3OXGA 2DB6A 1Z7KB 2NU3I 1FYBA 1K7TA 3UGDA 2GIVA 1OVOA 3MEKA 3VDPA 2JA1A 1TIHA 2FNFX 1TBRR 2OD1A 5EX3A 1X74A 2E73A 1SGQI 1TBNA 2V53A 3TO9A 1UVGA 3GOXA 1NUBA 1V1HA 1R0RI 2N71A 3TO7A 5JHWC 1CSOI 4JCVE 1CGJI 1CE3A 1FAQA 2QQCA 2ELIA 1FY7A 2SGPI 3SEKC 1ULNA 4L9MA 1PTRA 1PPFI 1V1IA 1WGTA 1YTPA 2J87A 2SGFI 2KMQA 3R5BA 4GI3C 3R5AA 1MJBA 1Y1BA 2PQ8A 1PCEA 2YQPA 2WGCA 3OXFA 5FUWA 1H0ZA 2ROWA 1NXUA 1OYVI 2ERWA 2B0UC 2KCXA 2ODDA 3TJQA 7WGAA 1MJAA 4UXIA 3BJIA 2K9HA 1P9ZA 5E3PA 1TUSA 4UXJA 3SGBI 3TO6A 1M8CA 2ENZA 1HDLA 3QTLD 1P9GA 2KMPA 2LB7A 1TURA 1WKXA 1CT2I 1BUSA 4HGUA 5DAEA 2QPOA 5J8CA 2ARPF 1HPTA 2CJSC 1MT1A 2JXDA 1KMAA 2NU4I 3UEJA 2B8TA 1UHAA 1CT0I 1AN1I 3UGLA 2SGQI 2WVJA 1BMOA 2YUUA 1CGII 2WCYA 5FUXA 2N17A 1SGYI 2RIJA 5EX0A 3TOAA 1CT4I 1PTQA 2DIPA 3FC3A 2CWGA 5E3QA 2UVOA 1KBEA 4SGBI 1SGRI 2LUYA 1Z2IA 3SGQI 2L8EA 1PJUA 3CXLA 4MPIA 2A20A 1K7VA 2N1AB 1W4RA 2NU0I 2CWHA 4WP4A 9WGAA 2JYYA 2V1CA 1HJAI 2OVOA 3FSYA 5FUVA 2OU2A 2JZMA 2RC4A 3RU0A 1DS2I 2L7XA 5CCLA 2GKRI 2V1CC 1ULKA 1FARA 1WGCA 2F3CI 2SGEI 1IW4A 2QQDA 4E1RA 2VRWB 3E59A 5HI7A 1TBQR 2ORVA 3KY9A 3OVOA 3UOEA 2ENNA 1YU6C 2CWFA 1SGEI 3PDNA 4E1PA 1LR8A 3R5CA 3VDUA 5HQ8A 2Y0MA 2KMOA 1HEVA 1KBFA 1CHOI 5CCMA 3FSXA 2KMRA 1IY6A 1K7UA
chains in the Genus database with same CATH topology
1UVFA 2E5RA 2M5XA 3QWPA 2SGDI 1M8BA 2P6AC 4UXHA 1VDDA 2GKTI 2QQ0A 1SGNI 1LR7A 1R79A 1Y8FA 3OL0A 4A24A 2QQEA 3UGIA 1N13A 1RFHA 1Y1CA 2NU2I 1OMUA 5FUYA 2BUSA 2NU1I 2UZ3A 2J9RA 3D00A 1TGSI 1X4SA 2JW6A 3UEYA 3UFFA 1TBOA 1XBTA 2W0TA 1SGPI 1UUCA 2ORWA 2GVIA 3HH2C 1LR9A 2LEOA 4FKDA 1OMTA 4B6DA 2XRCA 3VE5A 1SGDI 3OXLA 1XA6A 2GKVA 1W3SA 1TOTA 1IY5A 3E2IA 2N52A 3B4VC 4OVOA 1DS3I 1U5KA 1XX6A 3OXGA 2DB6A 1Z7KB 2NU3I 1FYBA 3UGDA 1OVOA 3MEKA 3VDPA 2JA1A 1TIHA 2FNFX 1TBRR 2OD1A 5EX3A 1X74A 2E73A 1SGQI 1TBNA 2V53A 1UVGA 3GOXA 1NUBA 1V1HA 1R0RI 2N71A 5JHWC 1CSOI 4JCVE 1CGJI 1CE3A 1FAQA 2QQCA 2ELIA 2SGPI 3SEKC 4L9MA 1PTRA 1PPFI 1V1IA 1YTPA 2SGFI 2J87A 4GI3C 2KMQA 1H0ZA 1Y1BA 2YQPA 1PCEA 3OXFA 5FUWA 2ROWA 1OYVI 2ERWA 2KCXA 2B0UC 2ODDA 3TJQA 4UXIA 3BJIA 2K9HA 1TUSA 4UXJA 3SGBI 1M8CA 2ENZA 1HDLA 3QTLD 2KMPA 1TURA 1CT2I 1BUSA 4HGUA 5DAEA 2QPOA 2ARPF 1HPTA 2CJSC 1MT1A 2JXDA 1KMAA 2NU4I 3UEJA 2B8TA 1CT0I 1AN1I 3UGLA 2SGQI 2WVJA 1BMOA 2YUUA 1CGII 2WCYA 5FUXA 2N17A 1SGYI 5EX0A 1CT4I 1PTQA 2DIPA 3FC3A 1KBEA 4SGBI 1SGRI 2LUYA 3SGQI 2L8EA 1PJUA 3CXLA 2A20A 2N1AB 2NU0I 1W4RA 2JYYA 2V1CA 1HJAI 2OVOA 5FUVA 2JZMA 3RU0A 1DS2I 2L7XA 5CCLA 2GKRI 2V1CC 1FARA 2F3CI 2SGEI 1IW4A 2QQDA 4E1RA 2VRWB 3E59A 5HI7A 1TBQR 2ORVA 3KY9A 3OVOA 2ENNA 1YU6C 4E1PA 1SGEI 3PDNA 1LR8A 3VDUA 5HQ8A 2KMOA 1KBFA 1CHOI 5CCMA 2KMRA 1IY6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1UVF A;  2M5X A;  2SGD I;  1M8B A;  2P6A C;  2GKT I;  1SGN I;  1LR7 A;  1N13 A;  1Y1C A;  2NU2 I;  1OMU A;  2BUS A;  2NU1 I;  1TGS I;  1SGP I;  1UUC A;  3HH2 C;  1LR9 A;  2LEO A;  1OMT A;  2XRC A;  1SGD I;  2GKV A;  1IY5 A;  2N52 A;  3B4V C;  4OVO A;  1DS3 I;  1Z7K B;  2NU3 I;  1FYB A;  1OVO A;  1TIH A;  1TBR R;  1SGQ I;  2V53 A;  1UVG A;  1NUB A;  1R0R I;  2N71 A;  5JHW C;  1CSO I;  1CE3 A;  1CGJ I;  2QQC A;  2SGP I;  3SEK C;  2SGF I;  1PPF I;  1YTP A;  4GI3 C;  2KMQ A;  1H0Z A;  1Y1B A;  1PCE A;  1OYV I;  2ERW A;  2KCX A;  2B0U C;  3TJQ A;  1TUS A;  3SGB I;  1M8C A;  1HDL A;  3QTL D;  2KMP A;  1TUR A;  1CT2 I;  1BUS A;  4HGU A;  5DAE A;  2ARP F;  1HPT A;  1MT1 A;  2JXD A;  1KMA A;  2NU4 I;  1CT0 I;  1AN1 I;  2SGQ I;  1BMO A;  1CGI I;  2WCY A;  2N17 A;  1SGY I;  1CT4 I;  3SGQ I;  4SGB I;  1SGR I;  1PJU A;  2NU0 I;  2JYY A;  1HJA I;  2OVO A;  2JZM A;  1DS2 I;  2GKR I;  2F3C I;  2SGE I;  1IW4 A;  2QQD A;  1TBQ R;  3OVO A;  1YU6 C;  1SGE I;  1LR8 A;  2KMO A;  1CHO I;  2KMR A;  1IY6 A; 
#chains in the Genus database with same CATH topology
 1UVF A;  2E5R A;  2M5X A;  3QWP A;  2SGD I;  1M8B A;  2P6A C;  4UXH A;  1VDD A;  2GKT I;  2X52 A;  2QQ0 A;  1SGN I;  1LR7 A;  1R79 A;  1Y8F A;  1ULM A;  3OL0 A;  4A24 A;  2QQE A;  2X3T A;  3UGI A;  1N13 A;  4AML A;  1RFH A;  1Y1C A;  3TOB A;  2NU2 I;  3R5D A;  1OMU A;  5FUY A;  2BUS A;  2NU1 I;  2UZ3 A;  2J9R A;  1Q9B A;  3D00 A;  1TGS I;  1X4S A;  2JW6 A;  3QAH A;  3UEY A;  3UFF A;  1TBO A;  1XBT A;  2W0T A;  5E3R A;  1SGP I;  1UUC A;  2ORW A;  2GVI A;  3HH2 C;  1LR9 A;  2LEO A;  2OZU A;  1MJ9 A;  1OMT A;  4FKD A;  4B6D A;  2XRC A;  4DNC A;  5J8F A;  3VE5 A;  1SGD I;  3OXL A;  1XA6 A;  2GKV A;  1W3S A;  1TOT A;  1IY5 A;  1S20 A;  2N52 A;  3E2I A;  3B4V C;  4OVO A;  2DKV A;  1DS3 I;  1U5K A;  1XX6 A;  1WTJ A;  3OXG A;  2DB6 A;  1Z7K B;  2NU3 I;  1FYB A;  1K7T A;  3UGD A;  2GIV A;  1OVO A;  3MEK A;  3VDP A;  2JA1 A;  1TIH A;  2FNF X;  1TBR R;  2OD1 A;  5EX3 A;  1X74 A;  2E73 A;  1SGQ I;  1TBN A;  2V53 A;  3TO9 A;  1UVG A;  3GOX A;  1NUB A;  1V1H A;  1R0R I;  2N71 A;  3TO7 A;  5JHW C;  1CSO I;  4JCV E;  1CGJ I;  1CE3 A;  1FAQ A;  2QQC A;  2ELI A;  1FY7 A;  2SGP I;  3SEK C;  1ULN A;  4L9M A;  1PTR A;  1PPF I;  1V1I A;  1WGT A;  1YTP A;  2J87 A;  2SGF I;  2KMQ A;  3R5B A;  4GI3 C;  3R5A A;  1MJB A;  1Y1B A;  2PQ8 A;  1PCE A;  2YQP A;  2WGC A;  3OXF A;  5FUW A;  1H0Z A;  2ROW A;  1NXU A;  1OYV I;  2ERW A;  2B0U C;  2KCX A;  2ODD A;  3TJQ A;  7WGA A;  1MJA A;  4UXI A;  3BJI A;  2K9H A;  1P9Z A;  5E3P A;  1TUS A;  4UXJ A;  3SGB I;  3TO6 A;  1M8C A;  2ENZ A;  1HDL A;  3QTL D;  1P9G A;  2KMP A;  2LB7 A;  1TUR A;  1WKX A;  1CT2 I;  1BUS A;  4HGU A;  5DAE A;  2QPO A;  5J8C A;  2ARP F;  1HPT A;  2CJS C;  1MT1 A;  2JXD A;  1KMA A;  2NU4 I;  3UEJ A;  2B8T A;  1UHA A;  1CT0 I;  1AN1 I;  3UGL A;  2SGQ I;  2WVJ A;  1BMO A;  2YUU A;  1CGI I;  2WCY A;  5FUX A;  2N17 A;  1SGY I;  2RIJ A;  5EX0 A;  3TOA A;  1CT4 I;  1PTQ A;  2DIP A;  3FC3 A;  2CWG A;  5E3Q A;  2UVO A;  1KBE A;  4SGB I;  1SGR I;  2LUY A;  1Z2I A;  3SGQ I;  2L8E A;  1PJU A;  3CXL A;  4MPI A;  2A20 A;  1K7V A;  2N1A B;  1W4R A;  2NU0 I;  2CWH A;  4WP4 A;  9WGA A;  2JYY A;  2V1C A;  1HJA I;  2OVO A;  3FSY A;  5FUV A;  2OU2 A;  2JZM A;  2RC4 A;  3RU0 A;  1DS2 I;  2L7X A;  5CCL A;  2GKR I;  2V1C C;  1ULK A;  1FAR A;  1WGC A;  2F3C I;  2SGE I;  1IW4 A;  2QQD A;  4E1R A;  2VRW B;  3E59 A;  5HI7 A;  1TBQ R;  2ORV A;  3KY9 A;  3OVO A;  3UOE A;  2ENN A;  1YU6 C;  2CWF A;  1SGE I;  3PDN A;  4E1P A;  1LR8 A;  3R5C A;  3VDU A;  5HQ8 A;  2Y0M A;  2KMO A;  1HEV A;  1KBF A;  1CHO I;  5CCM A;  3FSX A;  2KMR A;  1IY6 A;  1K7U A; 
#chains in the Genus database with same CATH homology
 1UVF A;  2E5R A;  2M5X A;  3QWP A;  2SGD I;  1M8B A;  2P6A C;  4UXH A;  1VDD A;  2GKT I;  2QQ0 A;  1SGN I;  1LR7 A;  1R79 A;  1Y8F A;  3OL0 A;  4A24 A;  2QQE A;  3UGI A;  1N13 A;  1RFH A;  1Y1C A;  2NU2 I;  1OMU A;  5FUY A;  2BUS A;  2NU1 I;  2UZ3 A;  2J9R A;  3D00 A;  1TGS I;  1X4S A;  2JW6 A;  3UEY A;  3UFF A;  1TBO A;  1XBT A;  2W0T A;  1SGP I;  1UUC A;  2ORW A;  2GVI A;  3HH2 C;  1LR9 A;  2LEO A;  4FKD A;  1OMT A;  4B6D A;  2XRC A;  3VE5 A;  1SGD I;  3OXL A;  1XA6 A;  2GKV A;  1W3S A;  1TOT A;  1IY5 A;  3E2I A;  2N52 A;  3B4V C;  4OVO A;  1DS3 I;  1U5K A;  1XX6 A;  3OXG A;  2DB6 A;  1Z7K B;  2NU3 I;  1FYB A;  3UGD A;  1OVO A;  3MEK A;  3VDP A;  2JA1 A;  1TIH A;  2FNF X;  1TBR R;  2OD1 A;  5EX3 A;  1X74 A;  2E73 A;  1SGQ I;  1TBN A;  2V53 A;  1UVG A;  3GOX A;  1NUB A;  1V1H A;  1R0R I;  2N71 A;  5JHW C;  1CSO I;  4JCV E;  1CGJ I;  1CE3 A;  1FAQ A;  2QQC A;  2ELI A;  2SGP I;  3SEK C;  4L9M A;  1PTR A;  1PPF I;  1V1I A;  1YTP A;  2SGF I;  2J87 A;  4GI3 C;  2KMQ A;  1H0Z A;  1Y1B A;  2YQP A;  1PCE A;  3OXF A;  5FUW A;  2ROW A;  1OYV I;  2ERW A;  2KCX A;  2B0U C;  2ODD A;  3TJQ A;  4UXI A;  3BJI A;  2K9H A;  1TUS A;  4UXJ A;  3SGB I;  1M8C A;  2ENZ A;  1HDL A;  3QTL D;  2KMP A;  1TUR A;  1CT2 I;  1BUS A;  4HGU A;  5DAE A;  2QPO A;  2ARP F;  1HPT A;  2CJS C;  1MT1 A;  2JXD A;  1KMA A;  2NU4 I;  3UEJ A;  2B8T A;  1CT0 I;  1AN1 I;  3UGL A;  2SGQ I;  2WVJ A;  1BMO A;  2YUU A;  1CGI I;  2WCY A;  5FUX A;  2N17 A;  1SGY I;  5EX0 A;  1CT4 I;  1PTQ A;  2DIP A;  3FC3 A;  1KBE A;  4SGB I;  1SGR I;  2LUY A;  3SGQ I;  2L8E A;  1PJU A;  3CXL A;  2A20 A;  2N1A B;  2NU0 I;  1W4R A;  2JYY A;  2V1C A;  1HJA I;  2OVO A;  5FUV A;  2JZM A;  3RU0 A;  1DS2 I;  2L7X A;  5CCL A;  2GKR I;  2V1C C;  1FAR A;  2F3C I;  2SGE I;  1IW4 A;  2QQD A;  4E1R A;  2VRW B;  3E59 A;  5HI7 A;  1TBQ R;  2ORV A;  3KY9 A;  3OVO A;  2ENN A;  1YU6 C;  4E1P A;  1SGE I;  3PDN A;  1LR8 A;  3VDU A;  5HQ8 A;  2KMO A;  1KBF A;  1CHO I;  5CCM A;  2KMR A;  1IY6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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