3QTLD

Structural basis for dual-inhibition mechanism of a non-classical kazal-type serine protease inhibitor from horseshoe crab in complex with subtilisin
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
75
structure length
75
Chain Sequence
APCPHTYKPVCGANGEVYDNECFLNKAGIEPAESWETCRGHELCPSVCTEEYDPVCVEGKIYGNRCMQSHFCGKV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for dual-inhibition mechanism of a non-classical kazal-type serine protease inhibitor from horseshoe crab in complex with subtilisin.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Bacillus licheniformis
molecule keywords Subtilisin-like serin protease
total genus 9
structure length 75
sequence length 75
ec nomenclature
pdb deposition date 2011-02-23
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 3qtlD00
1OMUA 2JYYA 4SGBI 1SGPI 5DAEA 1SGRI 5JHWC 2KMPA 1CGII 2OVOA 2NU2I 1MT1A 2KMQA 2SGDI 1M8BA 3SGQI 2WCYA 1YU6C 1SGQI 1UUCA 1PCEA 1HDLA 1SGEI 1TGSI 1AN1I 1NUBA 2N71A 2QQCA 2GKRI 1UVGA 2SGEI 3SEKC 3TJQA 1FYBA 2NU4I 1CGJI 2B0UC 1TBRR 1DS3I 1PPFI 2XRCA 1CT2I 1UVFA 2QQDA 2JXDA 2ARPF 2F3CI 2KMRA 2ERWA 1OVOA 1HPTA 4HGUA 1CT0I 2NU0I 2NU3I 1LR7A 1CSOI 1LR8A 2N17A 2SGFI 1SGDI 1Y1CA 1BMOA 3OVOA 1KMAA 2V53A 2GKVA 2M5XA 2GKTI 1OYVI 1OMTA 2SGQI 2SGPI 3QTLD 1N13A 1R0RI 1TBQR 1CE3A 1Y1BA 2BUSA 1IW4A 2N52A 1IY5A 4OVOA 1PJUA 3SGBI 1YTPA 1TIHA 1DS2I 1IY6A 1M8CA 1SGNI 3HH2C 2KMOA 2JZMA 2P6AC 1CHOI 2LEOA 4GI3C 1HJAI 1BUSA 1LR9A 1TUSA 1TURA 1H0ZA 1SGYI 2NU1I 3B4VC 2KCXA 1Z7KB 1CT4I
chains in the Genus database with same CATH superfamily
1WTJA 3PDNA 1OMUA 2JYYA 2OZUA 3UOEA 3TOAA 1P9GA 2LB7A 4SGBI 1SGPI 5DAEA 1SGRI 1Y8FA 2GVIA 3FSXA 5HI7A 1ULMA 4B6DA 2KMPA 4DNCA 1CGII 5JHWC 2OVOA 4UXJA 2NU2I 1MT1A 2DIPA 2KMQA 2QQEA 1M8BA 1K7TA 2SGDI 2WCYA 3SGQI 1Z2IA 2N1AB 2OD1A 3OXLA 1YU6C 3QWPA 2K9HA 3UFFA 1VDDA 1SGQI 2V1CC 1WKXA 1WGTA 3D00A 3VDUA 1UUCA 2QQ0A 1PTRA 2WGCA 3TOBA 1K7UA 1PCEA 3UGIA 1R79A 5FUYA 1HDLA 1SGEI 3MEKA 3R5AA 1KBEA 1TGSI 2Y0MA 5E3QA 2OU2A 2ROWA 5E3PA 5FUVA 1AN1I 5CCMA 1S20A 1NUBA 2DB6A 2N71A 2JA1A 2QQCA 2JW6A 5EX0A 2A20A 2FNFX 2GKRI 5E3RA 2QPOA 2ORWA 1P9ZA 1UVGA 4L9MA 2SGEI 2LUYA 5FUWA 3SEKC 4E1PA 3TJQA 1FYBA 2NU4I 1W4RA 3UEYA 1V1IA 1CGJI 2ORVA 3CXLA 3UGDA 3OL0A 7WGAA 5CCLA 2X3TA 2B0UC 2GIVA 3R5CA 1TBRR 4FKDA 3UEJA 2V1CA 1WGCA 1DS3I 1PPFI 2B8TA 2YQPA 2XRCA 1CT2I 1V1HA 1UVFA 2QQDA 1FARA 5HQ8A 2J9RA 2JXDA 2ARPF 3R5DA 2RIJA 4MPIA 2L8EA 2F3CI 1XX6A 2J87A 2KMRA 2UVOA 2ERWA 3BJIA 1OVOA 1HPTA 4HGUA 2CJSC 3OXFA 2YUUA 1CT0I 2NU0I 2NU3I 2W0TA 1LR7A 1CSOI 3FSYA 1LR8A 5EX3A 3RU0A 1TBNA 2N17A 2SGFI 1W3SA 1SGDI 1Y1CA 1XBTA 1PTQA 2L7XA 1BMOA 5J8CA 2ELIA 3OVOA 1K7VA 1MJBA 1Q9BA 1KMAA 2V53A 2GKVA 2M5XA 4UXHA 5J8FA 1TBOA 2E73A 1OYVI 2GKTI 1OMTA 2SGQI 1ULKA 2SGPI 2UZ3A 3VE5A 3QTLD 2WVJA 1N13A 2DKVA 1UHAA 1R0RI 1TBQR 4WP4A 1CE3A 1Y1BA 3E2IA 1FAQA 2BUSA 1IW4A 4JCVE 2N52A 1IY5A 1FY7A 1KBFA 4OVOA 1PJUA 3KY9A 1X4SA 3SGBI 2ENNA 1YTPA 3TO9A 1TIHA 2E5RA 4UXIA 4E1RA 2PQ8A 5FUXA 1DS2I 1IY6A 1M8CA 1SGNI 3HH2C 2KMOA 2JZMA 1XA6A 4AMLA 1ULNA 2P6AC 2X52A 1CHOI 1HEVA 2LEOA 3E59A 3R5BA 4GI3C 9WGAA 1TOTA 3FC3A 3QAHA 1MJAA 2VRWB 2ENZA 4A24A 2CWHA 1HJAI 1BUSA 1U5KA 2RC4A 1LR9A 2ODDA 3TO6A 3UGLA 1NXUA 3TO7A 2CWGA 1TUSA 1RFHA 1TURA 1H0ZA 2CWFA 1SGYI 2NU1I 3OXGA 3VDPA 3B4VC 2KCXA 3GOXA 1X74A 1MJ9A 1Z7KB 1CT4I
chains in the Genus database with same CATH topology
3PDNA 1OMUA 2JYYA 4SGBI 1SGPI 5DAEA 1SGRI 1Y8FA 2GVIA 5HI7A 4B6DA 5JHWC 2KMPA 1CGII 2OVOA 4UXJA 2NU2I 1MT1A 2DIPA 2KMQA 2QQEA 1M8BA 2SGDI 2WCYA 3SGQI 2N1AB 2OD1A 3OXLA 1YU6C 3QWPA 2K9HA 3UFFA 1VDDA 1SGQI 2V1CC 3D00A 3VDUA 1UUCA 2QQ0A 1PTRA 1PCEA 3UGIA 1R79A 5FUYA 1HDLA 1SGEI 3MEKA 1KBEA 1TGSI 5FUVA 2ROWA 1AN1I 5CCMA 1NUBA 2DB6A 2N71A 2JA1A 2QQCA 2JW6A 5EX0A 2A20A 2FNFX 2GKRI 2QPOA 2ORWA 1UVGA 4L9MA 2SGEI 2LUYA 5FUWA 3SEKC 4E1PA 3TJQA 1FYBA 2NU4I 1W4RA 3UEYA 1V1IA 1CGJI 2ORVA 3CXLA 3UGDA 3OL0A 5CCLA 2B0UC 4FKDA 1TBRR 3UEJA 2V1CA 1DS3I 1PPFI 2B8TA 2YQPA 2XRCA 1CT2I 1V1HA 1UVFA 2QQDA 1FARA 5HQ8A 2J9RA 2JXDA 2ARPF 2L8EA 2F3CI 1XX6A 2J87A 2KMRA 2ERWA 3BJIA 1OVOA 1HPTA 4HGUA 2CJSC 3OXFA 2YUUA 1CT0I 2NU0I 2NU3I 2W0TA 1LR7A 1CSOI 3RU0A 1LR8A 5EX3A 1TBNA 2N17A 2SGFI 1W3SA 1SGDI 1Y1CA 1XBTA 1PTQA 2L7XA 1BMOA 2ELIA 3OVOA 1KMAA 2V53A 2GKVA 2M5XA 4UXHA 1TBOA 2E73A 1OYVI 2GKTI 1OMTA 2SGQI 2SGPI 2UZ3A 3VE5A 3QTLD 2WVJA 1N13A 1R0RI 1TBQR 1CE3A 1Y1BA 3E2IA 1FAQA 2BUSA 1IW4A 4JCVE 2N52A 1IY5A 1KBFA 4OVOA 1PJUA 3KY9A 1X4SA 3SGBI 2ENNA 1YTPA 1TIHA 2E5RA 4UXIA 4E1RA 5FUXA 1DS2I 1IY6A 1M8CA 1SGNI 3HH2C 2KMOA 2JZMA 1XA6A 2P6AC 1CHOI 2LEOA 3E59A 4GI3C 1TOTA 3FC3A 2VRWB 2ENZA 4A24A 1HJAI 1BUSA 1U5KA 1LR9A 2ODDA 3UGLA 1TUSA 1RFHA 1TURA 1H0ZA 1SGYI 2NU1I 3OXGA 3VDPA 3B4VC 2KCXA 3GOXA 1X74A 1Z7KB 1CT4I
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1OMU A;  2JYY A;  4SGB I;  1SGP I;  5DAE A;  1SGR I;  5JHW C;  2KMP A;  1CGI I;  2OVO A;  2NU2 I;  1MT1 A;  2KMQ A;  2SGD I;  1M8B A;  3SGQ I;  2WCY A;  1YU6 C;  1SGQ I;  1UUC A;  1PCE A;  1HDL A;  1SGE I;  1TGS I;  1AN1 I;  1NUB A;  2N71 A;  2QQC A;  2GKR I;  1UVG A;  2SGE I;  3SEK C;  3TJQ A;  1FYB A;  2NU4 I;  1CGJ I;  2B0U C;  1TBR R;  1DS3 I;  1PPF I;  2XRC A;  1CT2 I;  1UVF A;  2QQD A;  2JXD A;  2ARP F;  2F3C I;  2KMR A;  2ERW A;  1OVO A;  1HPT A;  4HGU A;  1CT0 I;  2NU0 I;  2NU3 I;  1LR7 A;  1CSO I;  1LR8 A;  2N17 A;  2SGF I;  1SGD I;  1Y1C A;  1BMO A;  3OVO A;  1KMA A;  2V53 A;  2GKV A;  2M5X A;  2GKT I;  1OYV I;  1OMT A;  2SGQ I;  2SGP I;  3QTL D;  1N13 A;  1R0R I;  1TBQ R;  1CE3 A;  1Y1B A;  2BUS A;  1IW4 A;  2N52 A;  1IY5 A;  4OVO A;  1PJU A;  3SGB I;  1YTP A;  1TIH A;  1DS2 I;  1IY6 A;  1M8C A;  1SGN I;  3HH2 C;  2KMO A;  2JZM A;  2P6A C;  1CHO I;  2LEO A;  4GI3 C;  1HJA I;  1BUS A;  1LR9 A;  1TUS A;  1TUR A;  1H0Z A;  1SGY I;  2NU1 I;  3B4V C;  2KCX A;  1Z7K B;  1CT4 I; 
#chains in the Genus database with same CATH topology
 1WTJ A;  3PDN A;  1OMU A;  2JYY A;  2OZU A;  3UOE A;  3TOA A;  1P9G A;  2LB7 A;  4SGB I;  1SGP I;  5DAE A;  1SGR I;  1Y8F A;  2GVI A;  3FSX A;  5HI7 A;  1ULM A;  4B6D A;  2KMP A;  4DNC A;  1CGI I;  5JHW C;  2OVO A;  4UXJ A;  2NU2 I;  1MT1 A;  2DIP A;  2KMQ A;  2QQE A;  1M8B A;  1K7T A;  2SGD I;  2WCY A;  3SGQ I;  1Z2I A;  2N1A B;  2OD1 A;  3OXL A;  1YU6 C;  3QWP A;  2K9H A;  3UFF A;  1VDD A;  1SGQ I;  2V1C C;  1WKX A;  1WGT A;  3D00 A;  3VDU A;  1UUC A;  2QQ0 A;  1PTR A;  2WGC A;  3TOB A;  1K7U A;  1PCE A;  3UGI A;  1R79 A;  5FUY A;  1HDL A;  1SGE I;  3MEK A;  3R5A A;  1KBE A;  1TGS I;  2Y0M A;  5E3Q A;  2OU2 A;  2ROW A;  5E3P A;  5FUV A;  1AN1 I;  5CCM A;  1S20 A;  1NUB A;  2DB6 A;  2N71 A;  2JA1 A;  2QQC A;  2JW6 A;  5EX0 A;  2A20 A;  2FNF X;  2GKR I;  5E3R A;  2QPO A;  2ORW A;  1P9Z A;  1UVG A;  4L9M A;  2SGE I;  2LUY A;  5FUW A;  3SEK C;  4E1P A;  3TJQ A;  1FYB A;  2NU4 I;  1W4R A;  3UEY A;  1V1I A;  1CGJ I;  2ORV A;  3CXL A;  3UGD A;  3OL0 A;  7WGA A;  5CCL A;  2X3T A;  2B0U C;  2GIV A;  3R5C A;  1TBR R;  4FKD A;  3UEJ A;  2V1C A;  1WGC A;  1DS3 I;  1PPF I;  2B8T A;  2YQP A;  2XRC A;  1CT2 I;  1V1H A;  1UVF A;  2QQD A;  1FAR A;  5HQ8 A;  2J9R A;  2JXD A;  2ARP F;  3R5D A;  2RIJ A;  4MPI A;  2L8E A;  2F3C I;  1XX6 A;  2J87 A;  2KMR A;  2UVO A;  2ERW A;  3BJI A;  1OVO A;  1HPT A;  4HGU A;  2CJS C;  3OXF A;  2YUU A;  1CT0 I;  2NU0 I;  2NU3 I;  2W0T A;  1LR7 A;  1CSO I;  3FSY A;  1LR8 A;  5EX3 A;  3RU0 A;  1TBN A;  2N17 A;  2SGF I;  1W3S A;  1SGD I;  1Y1C A;  1XBT A;  1PTQ A;  2L7X A;  1BMO A;  5J8C A;  2ELI A;  3OVO A;  1K7V A;  1MJB A;  1Q9B A;  1KMA A;  2V53 A;  2GKV A;  2M5X A;  4UXH A;  5J8F A;  1TBO A;  2E73 A;  1OYV I;  2GKT I;  1OMT A;  2SGQ I;  1ULK A;  2SGP I;  2UZ3 A;  3VE5 A;  3QTL D;  2WVJ A;  1N13 A;  2DKV A;  1UHA A;  1R0R I;  1TBQ R;  4WP4 A;  1CE3 A;  1Y1B A;  3E2I A;  1FAQ A;  2BUS A;  1IW4 A;  4JCV E;  2N52 A;  1IY5 A;  1FY7 A;  1KBF A;  4OVO A;  1PJU A;  3KY9 A;  1X4S A;  3SGB I;  2ENN A;  1YTP A;  3TO9 A;  1TIH A;  2E5R A;  4UXI A;  4E1R A;  2PQ8 A;  5FUX A;  1DS2 I;  1IY6 A;  1M8C A;  1SGN I;  3HH2 C;  2KMO A;  2JZM A;  1XA6 A;  4AML A;  1ULN A;  2P6A C;  2X52 A;  1CHO I;  1HEV A;  2LEO A;  3E59 A;  3R5B A;  4GI3 C;  9WGA A;  1TOT A;  3FC3 A;  3QAH A;  1MJA A;  2VRW B;  2ENZ A;  4A24 A;  2CWH A;  1HJA I;  1BUS A;  1U5K A;  2RC4 A;  1LR9 A;  2ODD A;  3TO6 A;  3UGL A;  1NXU A;  3TO7 A;  2CWG A;  1TUS A;  1RFH A;  1TUR A;  1H0Z A;  2CWF A;  1SGY I;  2NU1 I;  3OXG A;  3VDP A;  3B4V C;  2KCX A;  3GOX A;  1X74 A;  1MJ9 A;  1Z7K B;  1CT4 I; 
#chains in the Genus database with same CATH homology
 3PDN A;  1OMU A;  2JYY A;  4SGB I;  1SGP I;  5DAE A;  1SGR I;  1Y8F A;  2GVI A;  5HI7 A;  4B6D A;  5JHW C;  2KMP A;  1CGI I;  2OVO A;  4UXJ A;  2NU2 I;  1MT1 A;  2DIP A;  2KMQ A;  2QQE A;  1M8B A;  2SGD I;  2WCY A;  3SGQ I;  2N1A B;  2OD1 A;  3OXL A;  1YU6 C;  3QWP A;  2K9H A;  3UFF A;  1VDD A;  1SGQ I;  2V1C C;  3D00 A;  3VDU A;  1UUC A;  2QQ0 A;  1PTR A;  1PCE A;  3UGI A;  1R79 A;  5FUY A;  1HDL A;  1SGE I;  3MEK A;  1KBE A;  1TGS I;  5FUV A;  2ROW A;  1AN1 I;  5CCM A;  1NUB A;  2DB6 A;  2N71 A;  2JA1 A;  2QQC A;  2JW6 A;  5EX0 A;  2A20 A;  2FNF X;  2GKR I;  2QPO A;  2ORW A;  1UVG A;  4L9M A;  2SGE I;  2LUY A;  5FUW A;  3SEK C;  4E1P A;  3TJQ A;  1FYB A;  2NU4 I;  1W4R A;  3UEY A;  1V1I A;  1CGJ I;  2ORV A;  3CXL A;  3UGD A;  3OL0 A;  5CCL A;  2B0U C;  4FKD A;  1TBR R;  3UEJ A;  2V1C A;  1DS3 I;  1PPF I;  2B8T A;  2YQP A;  2XRC A;  1CT2 I;  1V1H A;  1UVF A;  2QQD A;  1FAR A;  5HQ8 A;  2J9R A;  2JXD A;  2ARP F;  2L8E A;  2F3C I;  1XX6 A;  2J87 A;  2KMR A;  2ERW A;  3BJI A;  1OVO A;  1HPT A;  4HGU A;  2CJS C;  3OXF A;  2YUU A;  1CT0 I;  2NU0 I;  2NU3 I;  2W0T A;  1LR7 A;  1CSO I;  3RU0 A;  1LR8 A;  5EX3 A;  1TBN A;  2N17 A;  2SGF I;  1W3S A;  1SGD I;  1Y1C A;  1XBT A;  1PTQ A;  2L7X A;  1BMO A;  2ELI A;  3OVO A;  1KMA A;  2V53 A;  2GKV A;  2M5X A;  4UXH A;  1TBO A;  2E73 A;  1OYV I;  2GKT I;  1OMT A;  2SGQ I;  2SGP I;  2UZ3 A;  3VE5 A;  3QTL D;  2WVJ A;  1N13 A;  1R0R I;  1TBQ R;  1CE3 A;  1Y1B A;  3E2I A;  1FAQ A;  2BUS A;  1IW4 A;  4JCV E;  2N52 A;  1IY5 A;  1KBF A;  4OVO A;  1PJU A;  3KY9 A;  1X4S A;  3SGB I;  2ENN A;  1YTP A;  1TIH A;  2E5R A;  4UXI A;  4E1R A;  5FUX A;  1DS2 I;  1IY6 A;  1M8C A;  1SGN I;  3HH2 C;  2KMO A;  2JZM A;  1XA6 A;  2P6A C;  1CHO I;  2LEO A;  3E59 A;  4GI3 C;  1TOT A;  3FC3 A;  2VRW B;  2ENZ A;  4A24 A;  1HJA I;  1BUS A;  1U5K A;  1LR9 A;  2ODD A;  3UGL A;  1TUS A;  1RFH A;  1TUR A;  1H0Z A;  1SGY I;  2NU1 I;  3OXG A;  3VDP A;  3B4V C;  2KCX A;  3GOX A;  1X74 A;  1Z7K B;  1CT4 I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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