5JHWC

Crystal structure of the gdf11:follistatin 288 complex
Total Genus 65
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
288
structure length
282
Chain Sequence
GNCWLRQAKNGRCQVLYKTELSKEECCSTGRLSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSCN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cytokine/signaling protein
molecule keywords Growth/differentiation factor 11
publication title Structural basis for potency differences between GDF8 and GDF11.
pubmed doi rcsb
source organism Homo sapiens
total genus 65
structure length 282
sequence length 288
chains with identical sequence D
ec nomenclature
pdb deposition date 2016-04-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF07648 Kazal_2 Kazal-type serine protease inhibitor domain
C PF09289 FOLN Follistatin/Osteonectin-like EGF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 5jhwC04
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 5jhwC03
3.30.60.250 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 5jhwC02
3.90.290.10 Alpha Beta Alpha-Beta Complex Extracellular Matrix Fibrillin TGF-beta binding (TB) domain 5jhwC01
1SGEI 1KMAA 1TIHA 2M5XA 2GKVA 1TBQR 1CSOI 4OVOA 2NU4I 1TGSI 2QQCA 1YTPA 2P6AC 2KMRA 2F3CI 2KMQA 1LR9A 1FYBA 2OVOA 5JHWC 1CT0I 2LEOA 3QTLD 1OYVI 1HPTA 3SGQI 2ARPF 2JYYA 1PCEA 1KSQA 3HH2C 1UZJA 1UZKA 2B0UC 2NU2I 1UVGA 1CHOI 2NU0I 2KMPA 1TBRR 2ERWA 1Y1CA 2SGDI 5DAEA 2GKRI 1PPFI 4SGBI 1Y1BA 1BUSA 1OMTA 1DS2I 2KCXA 1NUBA 2BUSA 2WCYA 2N17A 3SEKC 1CT4I 1M8CA 1CT2I 1AN1I 2SGFI 1OVOA 1Z7KB 2NU1I 1TURA 1HDLA 3OVOA 1CGJI 1UZQA 2W86A 2N52A 1R0RI 1TUSA 2SGEI 1HJAI 1IY6A 1UZPA 2KMOA 2V53A 1SGDI 1UVFA 2JZMA 3B4VC 1DS3I 1MT1A 2QQDA 1SGYI 2SGPI 2SGQI 1SGNI 1APJA 2GKTI 1M8BA 1UUCA 2JXDA 1SGQI 1SGPI 3TJQA 3SGBI 1IY5A 2XRCA 1PJUA 1OMUA 4HGUA 1SGRI 1BMOA 1H0ZA 1IW4A 1CE3A 1LR7A 2N71A 4GI3C 1N13A 1YU6C 2NU3I 1CGII 1LR8A
chains in the Genus database with same CATH superfamily
2J87A 1W3SA 1SGEI 3UEYA 3RU0A 1TIHA 1KMAA 2M5XA 1TOTA 2GKVA 1RFHA 1TBQR 3OXLA 1CSOI 1HEVA 2ROWA 2CWGA 2ORVA 2NU4I 2VRWB 4OVOA 1TGSI 2QQCA 3MEKA 1YTPA 2P6AC 2RC4A 1K7TA 2DB6A 3TO6A 2KMRA 1KBEA 2F3CI 2KMQA 2OZUA 3E2IA 3UGIA 2OD1A 1LR9A 4A24A 1XBTA 1FYBA 2OVOA 3TOBA 2ODDA 5JHWC 5HQ8A 1CT0I 1R79A 2LEOA 2UZ3A 3QTLD 5EX3A 2W0TA 5FUYA 1OYVI 7WGAA 1HPTA 2WVJA 3SGQI 1WGTA 2ARPF 2JYYA 1PCEA 1KSQA 3HH2C 1UZJA 1UZKA 3UGDA 2B0UC 2NU2I 2J9RA 1P9GA 2JW6A 3D00A 5E3RA 2PQ8A 3VE5A 1UVGA 1CHOI 5FUVA 5CCLA 2NU0I 5FUWA 2KMPA 1PTQA 3TO7A 1TBRR 1S20A 9WGAA 2DIPA 2ERWA 2X52A 4L9MA 1FY7A 1Y1CA 1NXUA 4E1PA 2YQPA 2SGDI 1WKXA 2GKRI 5DAEA 3OXGA 1KBFA 1PPFI 1P9ZA 2V1CC 3PDNA 1WGCA 4SGBI 2RIJA 5J8FA 1Y1BA 1BUSA 3KY9A 3QWPA 2V1CA 1WTJA 3R5CA 5E3PA 1OMTA 1DS2I 3FSYA 2KCXA 1NUBA 2B8TA 2BUSA 5E3QA 2K9HA 2N1AB 2DKVA 2WCYA 5J8CA 1MJBA 2ELIA 2UVOA 3QAHA 2CWFA 2N17A 5FUXA 3SEKC 2JA1A 1CT4I 1K7VA 4AMLA 1M8CA 1CT2I 2E73A 4WP4A 3TO9A 1AN1I 2SGFI 5CCMA 4JCVE 1Q9BA 3GOXA 2L8EA 1OVOA 1Z7KB 4UXJA 2NU1I 2QQEA 1TURA 2QPOA 4B6DA 3UEJA 1VDDA 3OL0A 3UOEA 1ULMA 1HDLA 4UXHA 1TBNA 1FARA 3R5AA 3CXLA 4FKDA 3OVOA 4E1RA 1CGJI 3VDUA 1UZQA 2W86A 1ULNA 2L7XA 2N52A 1R0RI 4DNCA 1TUSA 2SGEI 1HJAI 2ORWA 1IY6A 1XX6A 2KMOA 1UZPA 1K7UA 2V53A 1SGDI 4MPIA 1UVFA 2JZMA 3B4VC 1DS3I 1Z2IA 1MT1A 2QQDA 1W4RA 1X4SA 1SGYI 2FNFX 2SGQI 1SGNI 2SGPI 1APJA 2GKTI 1M8BA 2ENNA 3FSXA 2LB7A 1V1HA 2ENZA 1UUCA 3VDPA 2WGCA 1Y8FA 4UXIA 2OU2A 5HI7A 2JXDA 2QQ0A 3BJIA 1UHAA 1SGQI 1SGPI 3TJQA 3SGBI 1IY5A 3R5BA 3TOAA 2XRCA 1XA6A 2CWHA 2LUYA 1PJUA 1OMUA 3E59A 3R5DA 1FAQA 1V1IA 4HGUA 1PTRA 3FC3A 1MJ9A 1SGRI 2E5RA 1ULKA 3OXFA 5EX0A 2X3TA 1BMOA 1H0ZA 2CJSC 2GIVA 1TBOA 1U5KA 1X74A 2GVIA 3UGLA 3UFFA 1LR7A 1IW4A 2N71A 4GI3C 2YUUA 1CE3A 1MJAA 1N13A 2A20A 1YU6C 2NU3I 2Y0MA 1CGII 1LR8A
chains in the Genus database with same CATH topology
2J87A 1W3SA 1SGEI 3UEYA 3RU0A 1TIHA 1KMAA 2M5XA 1TOTA 2GKVA 1RFHA 1TBQR 3OXLA 1CSOI 2ROWA 2VRWB 2ORVA 2NU4I 4OVOA 1TGSI 2QQCA 3MEKA 1YTPA 2P6AC 2DB6A 2KMRA 1KBEA 2F3CI 2KMQA 3E2IA 3UGIA 2OD1A 1LR9A 4A24A 1XBTA 1FYBA 2OVOA 2ODDA 5JHWC 5HQ8A 1CT0I 1R79A 2LEOA 2UZ3A 3QTLD 5EX3A 2W0TA 5FUYA 1OYVI 1HPTA 2WVJA 3SGQI 2ARPF 2JYYA 1PCEA 1KSQA 3HH2C 1UZJA 1UZKA 3UGDA 2B0UC 2NU2I 2J9RA 2JW6A 3D00A 3VE5A 1UVGA 1CHOI 5FUVA 5CCLA 2NU0I 5FUWA 2KMPA 1PTQA 1TBRR 2DIPA 2ERWA 4L9MA 1Y1CA 4E1PA 2YQPA 2SGDI 5DAEA 2GKRI 3OXGA 1KBFA 1PPFI 2V1CC 4SGBI 3PDNA 1Y1BA 1BUSA 3KY9A 3QWPA 2V1CA 1OMTA 1DS2I 2KCXA 1NUBA 2B8TA 2BUSA 2K9HA 2N1AB 2WCYA 2ELIA 5FUXA 2N17A 3SEKC 2JA1A 1CT4I 1M8CA 1CT2I 2E73A 1AN1I 2SGFI 5CCMA 4JCVE 3GOXA 2L8EA 1OVOA 1Z7KB 4UXJA 2NU1I 2QQEA 1TURA 2QPOA 4B6DA 3UEJA 1VDDA 3OL0A 1HDLA 4UXHA 1TBNA 1FARA 4FKDA 3CXLA 4E1RA 3OVOA 1CGJI 3VDUA 1UZQA 2W86A 2L7XA 2N52A 1R0RI 1TUSA 2SGEI 1HJAI 2ORWA 1IY6A 1XX6A 2KMOA 1UZPA 2V53A 1SGDI 1UVFA 2JZMA 3B4VC 1DS3I 1MT1A 2QQDA 1W4RA 1X4SA 1SGYI 2FNFX 2SGQI 1SGNI 2SGPI 1APJA 2GKTI 1M8BA 2ENNA 1V1HA 2ENZA 1UUCA 3VDPA 4UXIA 1Y8FA 5HI7A 2JXDA 2QQ0A 3BJIA 1SGQI 1SGPI 3TJQA 3SGBI 1IY5A 2XRCA 1XA6A 2LUYA 1PJUA 1OMUA 3E59A 1FAQA 1V1IA 4HGUA 1PTRA 3FC3A 2E5RA 1SGRI 3OXFA 5EX0A 1BMOA 1H0ZA 2CJSC 3UFFA 1TBOA 1U5KA 1X74A 2GVIA 3UGLA 1IW4A 1LR7A 1CE3A 2N71A 4GI3C 2YUUA 1N13A 2A20A 1YU6C 2NU3I 1CGII 1LR8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SGE I;  1KMA A;  1TIH A;  2M5X A;  2GKV A;  1TBQ R;  1CSO I;  4OVO A;  2NU4 I;  1TGS I;  2QQC A;  1YTP A;  2P6A C;  2KMR A;  2F3C I;  2KMQ A;  1LR9 A;  1FYB A;  2OVO A;  5JHW C;  1CT0 I;  2LEO A;  3QTL D;  1OYV I;  1HPT A;  3SGQ I;  2ARP F;  2JYY A;  1PCE A;  1KSQ A;  3HH2 C;  1UZJ A;  1UZK A;  2B0U C;  2NU2 I;  1UVG A;  1CHO I;  2NU0 I;  2KMP A;  1TBR R;  2ERW A;  1Y1C A;  2SGD I;  5DAE A;  2GKR I;  1PPF I;  4SGB I;  1Y1B A;  1BUS A;  1OMT A;  1DS2 I;  2KCX A;  1NUB A;  2BUS A;  2WCY A;  2N17 A;  3SEK C;  1CT4 I;  1M8C A;  1CT2 I;  1AN1 I;  2SGF I;  1OVO A;  1Z7K B;  2NU1 I;  1TUR A;  1HDL A;  3OVO A;  1CGJ I;  1UZQ A;  2W86 A;  2N52 A;  1R0R I;  1TUS A;  2SGE I;  1HJA I;  1IY6 A;  1UZP A;  2KMO A;  2V53 A;  1SGD I;  1UVF A;  2JZM A;  3B4V C;  1DS3 I;  1MT1 A;  2QQD A;  1SGY I;  2SGP I;  2SGQ I;  1SGN I;  1APJ A;  2GKT I;  1M8B A;  1UUC A;  2JXD A;  1SGQ I;  1SGP I;  3TJQ A;  3SGB I;  1IY5 A;  2XRC A;  1PJU A;  1OMU A;  4HGU A;  1SGR I;  1BMO A;  1H0Z A;  1IW4 A;  1CE3 A;  1LR7 A;  2N71 A;  4GI3 C;  1N13 A;  1YU6 C;  2NU3 I;  1CGI I;  1LR8 A; 
#chains in the Genus database with same CATH topology
 2J87 A;  1W3S A;  1SGE I;  3UEY A;  3RU0 A;  1TIH A;  1KMA A;  2M5X A;  1TOT A;  2GKV A;  1RFH A;  1TBQ R;  3OXL A;  1CSO I;  1HEV A;  2ROW A;  2CWG A;  2ORV A;  2NU4 I;  2VRW B;  4OVO A;  1TGS I;  2QQC A;  3MEK A;  1YTP A;  2P6A C;  2RC4 A;  1K7T A;  2DB6 A;  3TO6 A;  2KMR A;  1KBE A;  2F3C I;  2KMQ A;  2OZU A;  3E2I A;  3UGI A;  2OD1 A;  1LR9 A;  4A24 A;  1XBT A;  1FYB A;  2OVO A;  3TOB A;  2ODD A;  5JHW C;  5HQ8 A;  1CT0 I;  1R79 A;  2LEO A;  2UZ3 A;  3QTL D;  5EX3 A;  2W0T A;  5FUY A;  1OYV I;  7WGA A;  1HPT A;  2WVJ A;  3SGQ I;  1WGT A;  2ARP F;  2JYY A;  1PCE A;  1KSQ A;  3HH2 C;  1UZJ A;  1UZK A;  3UGD A;  2B0U C;  2NU2 I;  2J9R A;  1P9G A;  2JW6 A;  3D00 A;  5E3R A;  2PQ8 A;  3VE5 A;  1UVG A;  1CHO I;  5FUV A;  5CCL A;  2NU0 I;  5FUW A;  2KMP A;  1PTQ A;  3TO7 A;  1TBR R;  1S20 A;  9WGA A;  2DIP A;  2ERW A;  2X52 A;  4L9M A;  1FY7 A;  1Y1C A;  1NXU A;  4E1P A;  2YQP A;  2SGD I;  1WKX A;  2GKR I;  5DAE A;  3OXG A;  1KBF A;  1PPF I;  1P9Z A;  2V1C C;  3PDN A;  1WGC A;  4SGB I;  2RIJ A;  5J8F A;  1Y1B A;  1BUS A;  3KY9 A;  3QWP A;  2V1C A;  1WTJ A;  3R5C A;  5E3P A;  1OMT A;  1DS2 I;  3FSY A;  2KCX A;  1NUB A;  2B8T A;  2BUS A;  5E3Q A;  2K9H A;  2N1A B;  2DKV A;  2WCY A;  5J8C A;  1MJB A;  2ELI A;  2UVO A;  3QAH A;  2CWF A;  2N17 A;  5FUX A;  3SEK C;  2JA1 A;  1CT4 I;  1K7V A;  4AML A;  1M8C A;  1CT2 I;  2E73 A;  4WP4 A;  3TO9 A;  1AN1 I;  2SGF I;  5CCM A;  4JCV E;  1Q9B A;  3GOX A;  2L8E A;  1OVO A;  1Z7K B;  4UXJ A;  2NU1 I;  2QQE A;  1TUR A;  2QPO A;  4B6D A;  3UEJ A;  1VDD A;  3OL0 A;  3UOE A;  1ULM A;  1HDL A;  4UXH A;  1TBN A;  1FAR A;  3R5A A;  3CXL A;  4FKD A;  3OVO A;  4E1R A;  1CGJ I;  3VDU A;  1UZQ A;  2W86 A;  1ULN A;  2L7X A;  2N52 A;  1R0R I;  4DNC A;  1TUS A;  2SGE I;  1HJA I;  2ORW A;  1IY6 A;  1XX6 A;  2KMO A;  1UZP A;  1K7U A;  2V53 A;  1SGD I;  4MPI A;  1UVF A;  2JZM A;  3B4V C;  1DS3 I;  1Z2I A;  1MT1 A;  2QQD A;  1W4R A;  1X4S A;  1SGY I;  2FNF X;  2SGQ I;  1SGN I;  2SGP I;  1APJ A;  2GKT I;  1M8B A;  2ENN A;  3FSX A;  2LB7 A;  1V1H A;  2ENZ A;  1UUC A;  3VDP A;  2WGC A;  1Y8F A;  4UXI A;  2OU2 A;  5HI7 A;  2JXD A;  2QQ0 A;  3BJI A;  1UHA A;  1SGQ I;  1SGP I;  3TJQ A;  3SGB I;  1IY5 A;  3R5B A;  3TOA A;  2XRC A;  1XA6 A;  2CWH A;  2LUY A;  1PJU A;  1OMU A;  3E59 A;  3R5D A;  1FAQ A;  1V1I A;  4HGU A;  1PTR A;  3FC3 A;  1MJ9 A;  1SGR I;  2E5R A;  1ULK A;  3OXF A;  5EX0 A;  2X3T A;  1BMO A;  1H0Z A;  2CJS C;  2GIV A;  1TBO A;  1U5K A;  1X74 A;  2GVI A;  3UGL A;  3UFF A;  1LR7 A;  1IW4 A;  2N71 A;  4GI3 C;  2YUU A;  1CE3 A;  1MJA A;  1N13 A;  2A20 A;  1YU6 C;  2NU3 I;  2Y0M A;  1CGI I;  1LR8 A; 
#chains in the Genus database with same CATH homology
 2J87 A;  1W3S A;  1SGE I;  3UEY A;  3RU0 A;  1TIH A;  1KMA A;  2M5X A;  1TOT A;  2GKV A;  1RFH A;  1TBQ R;  3OXL A;  1CSO I;  2ROW A;  2VRW B;  2ORV A;  2NU4 I;  4OVO A;  1TGS I;  2QQC A;  3MEK A;  1YTP A;  2P6A C;  2DB6 A;  2KMR A;  1KBE A;  2F3C I;  2KMQ A;  3E2I A;  3UGI A;  2OD1 A;  1LR9 A;  4A24 A;  1XBT A;  1FYB A;  2OVO A;  2ODD A;  5JHW C;  5HQ8 A;  1CT0 I;  1R79 A;  2LEO A;  2UZ3 A;  3QTL D;  5EX3 A;  2W0T A;  5FUY A;  1OYV I;  1HPT A;  2WVJ A;  3SGQ I;  2ARP F;  2JYY A;  1PCE A;  1KSQ A;  3HH2 C;  1UZJ A;  1UZK A;  3UGD A;  2B0U C;  2NU2 I;  2J9R A;  2JW6 A;  3D00 A;  3VE5 A;  1UVG A;  1CHO I;  5FUV A;  5CCL A;  2NU0 I;  5FUW A;  2KMP A;  1PTQ A;  1TBR R;  2DIP A;  2ERW A;  4L9M A;  1Y1C A;  4E1P A;  2YQP A;  2SGD I;  5DAE A;  2GKR I;  3OXG A;  1KBF A;  1PPF I;  2V1C C;  4SGB I;  3PDN A;  1Y1B A;  1BUS A;  3KY9 A;  3QWP A;  2V1C A;  1OMT A;  1DS2 I;  2KCX A;  1NUB A;  2B8T A;  2BUS A;  2K9H A;  2N1A B;  2WCY A;  2ELI A;  5FUX A;  2N17 A;  3SEK C;  2JA1 A;  1CT4 I;  1M8C A;  1CT2 I;  2E73 A;  1AN1 I;  2SGF I;  5CCM A;  4JCV E;  3GOX A;  2L8E A;  1OVO A;  1Z7K B;  4UXJ A;  2NU1 I;  2QQE A;  1TUR A;  2QPO A;  4B6D A;  3UEJ A;  1VDD A;  3OL0 A;  1HDL A;  4UXH A;  1TBN A;  1FAR A;  4FKD A;  3CXL A;  4E1R A;  3OVO A;  1CGJ I;  3VDU A;  1UZQ A;  2W86 A;  2L7X A;  2N52 A;  1R0R I;  1TUS A;  2SGE I;  1HJA I;  2ORW A;  1IY6 A;  1XX6 A;  2KMO A;  1UZP A;  2V53 A;  1SGD I;  1UVF A;  2JZM A;  3B4V C;  1DS3 I;  1MT1 A;  2QQD A;  1W4R A;  1X4S A;  1SGY I;  2FNF X;  2SGQ I;  1SGN I;  2SGP I;  1APJ A;  2GKT I;  1M8B A;  2ENN A;  1V1H A;  2ENZ A;  1UUC A;  3VDP A;  4UXI A;  1Y8F A;  5HI7 A;  2JXD A;  2QQ0 A;  3BJI A;  1SGQ I;  1SGP I;  3TJQ A;  3SGB I;  1IY5 A;  2XRC A;  1XA6 A;  2LUY A;  1PJU A;  1OMU A;  3E59 A;  1FAQ A;  1V1I A;  4HGU A;  1PTR A;  3FC3 A;  2E5R A;  1SGR I;  3OXF A;  5EX0 A;  1BMO A;  1H0Z A;  2CJS C;  3UFF A;  1TBO A;  1U5K A;  1X74 A;  2GVI A;  3UGL A;  1IW4 A;  1LR7 A;  1CE3 A;  2N71 A;  4GI3 C;  2YUU A;  1N13 A;  2A20 A;  1YU6 C;  2NU3 I;  1CGI I;  1LR8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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