2CJSC

Structural basis for a munc13-1 homodimer - munc13-1 - rim heterodimer switch: c2-domains as versatile protein-protein interaction modules
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
54
structure length
54
Chain Sequence
APTCGICHKTKFADGCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for a Munc13-1 Homodimer to Munc13-1/Rim Heterodimer Switch.
pubmed doi rcsb
molecule tags Exocytosis
source organism Rattus norvegicus
molecule keywords UNC-13 HOMOLOG A
total genus 9
structure length 54
sequence length 54
ec nomenclature
pdb deposition date 2006-04-06
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.120 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 2cjsC01
2CJSC 2A20A
chains in the Genus database with same CATH superfamily
2BUSA 2N52A 1XA6A 2OU2A 2SGPI 3HH2C 3VDUA 2PQ8A 4SGBI 3SEKC 2E73A 3TO7A 3UEJA 4AMLA 1YTPA 2L7XA 3QTLD 1CT2I 1DS2I 2OD1A 2QQEA 1XBTA 1XX6A 3OL0A 7WGAA 2NU2I 1TBQR 1SGQI 2SGFI 1MJAA 3VE5A 2VRWB 2YQPA 1Y8FA 2OZUA 1FYBA 1ULKA 2NU3I 1V1HA 1HPTA 9WGAA 3E59A 1MJ9A 2QQDA 3GOXA 4MPIA 1CSOI 2LB7A 1NUBA 1LR7A 2SGDI 3UEYA 2X52A 2JW6A 2ENNA 2ORVA 1CHOI 2ORWA 4E1RA 2GVIA 2CJSC 5J8CA 1SGDI 1AN1I 1K7VA 2DIPA 2JYYA 2QPOA 1WTJA 1X74A 2SGEI 1CGJI 1Z2IA 5J8FA 3BJIA 1OMUA 2KMQA 1LR9A 4UXHA 3TO6A 5CCLA 3OVOA 2WVJA 5FUVA 5CCMA 2K9HA 1Z7KB 2F3CI 1HEVA 2Y0MA 1UVGA 2KMRA 1UUCA 2NU1I 5FUXA 1R0RI 1M8CA 1CT4I 1PTRA 1MJBA 2LEOA 2V1CA 1LR8A 2FNFX 3QAHA 5DAEA 5FUYA 1WGTA 4UXJA 3UOEA 4E1PA 2WCYA 1OYVI 5E3RA 1OVOA 2A20A 3TJQA 1W3SA 3R5AA 4JCVE 2J87A 1YU6C 4DNCA 2UZ3A 1SGNI 1Q9BA 2CWHA 1TOTA 4FKDA 1K7TA 1CT0I 2B0UC 4WP4A 2GKTI 1HJAI 5HI7A 2NU0I 2V1CC 2KCXA 2V53A 3FSXA 1N13A 2XRCA 3KY9A 3PDNA 5EX0A 1H0ZA 5E3QA 2L8EA 5EX3A 3B4VC 3R5BA 4L9MA 2KMPA 1TUSA 1SGPI 1S20A 2DB6A 1NXUA 1U5KA 1TBOA 2ARPF 2N71A 1HDLA 1ULMA 3D00A 2UVOA 2X3TA 1BUSA 1PPFI 3UGDA 1BMOA 1CE3A 1RFHA 1WGCA 1KBEA 2B8TA 3QWPA 3OXLA 2GKRI 1M8BA 1CGII 1SGYI 3MEKA 3E2IA 3RU0A 3FC3A 1TIHA 1TBNA 5JHWC 3TOBA 1PJUA 3TO9A 1P9ZA 2GIVA 2RIJA 2M5XA 1IY6A 1SGRI 1FY7A 1ULNA 1UHAA 2DKVA 3FSYA 1P9GA 2ENZA 1FARA 2NU4I 1Y1CA 1IY5A 1DS3I 2CWFA 4B6DA 1IW4A 3CXLA 1TGSI 3R5DA 1FAQA 1UVFA 2ELIA 3UGIA 2YUUA 4GI3C 1X4SA 2OVOA 1KBFA 3OXFA 1W4RA 3VDPA 5HQ8A 2QQ0A 1TBRR 1Y1BA 2RC4A 2P6AC 3SGQI 3SGBI 4UXIA 1K7UA 1VDDA 2JZMA 2ROWA 2SGQI 1OMTA 2ODDA 2JA1A 1PTQA 3UFFA 2CWGA 5E3PA 3OXGA 2GKVA 1WKXA 2E5RA 2ERWA 2JXDA 2N1AB 2QQCA 3TOAA 3UGLA 4HGUA 1V1IA 1TURA 4OVOA 3R5CA 1PCEA 1R79A 1KMAA 2W0TA 5FUWA 2J9RA 2WGCA 4A24A 1SGEI 1MT1A 2N17A 2KMOA 2LUYA
chains in the Genus database with same CATH topology
2BUSA 2N52A 1XA6A 2SGPI 3HH2C 3VDUA 4SGBI 3SEKC 2E73A 3UEJA 1YTPA 2L7XA 3QTLD 1CT2I 1DS2I 2OD1A 2QQEA 1XBTA 1XX6A 3OL0A 2NU2I 1TBQR 1SGQI 2SGFI 3VE5A 2VRWB 2YQPA 1Y8FA 1FYBA 2NU3I 1V1HA 1HPTA 3E59A 2QQDA 3GOXA 1CSOI 1NUBA 1LR7A 2SGDI 3UEYA 2JW6A 2ENNA 2ORVA 1CHOI 2ORWA 2GVIA 2CJSC 1SGDI 1AN1I 2DIPA 2QPOA 2JYYA 1X74A 2SGEI 1CGJI 3BJIA 1OMUA 2KMQA 1LR9A 4UXHA 5CCLA 3OVOA 2WVJA 5FUVA 5CCMA 2K9HA 1Z7KB 2F3CI 1UVGA 2KMRA 1UUCA 2NU1I 5FUXA 1R0RI 1M8CA 1CT4I 1PTRA 2LEOA 2V1CA 4E1RA 1LR8A 2FNFX 5DAEA 4E1PA 5FUYA 4UXJA 2WCYA 1OYVI 1OVOA 2A20A 3TJQA 1W3SA 4JCVE 2J87A 1YU6C 2UZ3A 1SGNI 1TOTA 4FKDA 1CT0I 2B0UC 2GKTI 1HJAI 5HI7A 2NU0I 2V1CC 2KCXA 2V53A 3KY9A 1N13A 2XRCA 3PDNA 5EX0A 1H0ZA 2L8EA 5EX3A 3B4VC 4L9MA 2KMPA 1TUSA 1SGPI 2DB6A 1U5KA 1TBOA 2ARPF 2N71A 1HDLA 3D00A 1BUSA 1PPFI 3UGDA 1BMOA 1CE3A 1RFHA 1KBEA 2B8TA 3QWPA 3OXLA 2GKRI 1M8BA 1CGII 1SGYI 3MEKA 3E2IA 3RU0A 3FC3A 1TIHA 1TBNA 5JHWC 1PJUA 2M5XA 1IY6A 1SGRI 2ENZA 1FARA 2NU4I 1Y1CA 1IY5A 1DS3I 4B6DA 1IW4A 3CXLA 1TGSI 1FAQA 1UVFA 2ELIA 3UGIA 2YUUA 4GI3C 1X4SA 2OVOA 1KBFA 3OXFA 1W4RA 3VDPA 5HQ8A 2QQ0A 1TBRR 1Y1BA 3SGQI 2P6AC 3SGBI 4UXIA 2SGQI 1VDDA 2JZMA 2ROWA 1OMTA 2ODDA 2JA1A 1PTQA 3UFFA 3OXGA 2GKVA 2JXDA 2E5RA 2ERWA 2N1AB 2QQCA 3UGLA 4HGUA 1V1IA 1TURA 4OVOA 1PCEA 1R79A 1KMAA 2W0TA 5FUWA 2J9RA 4A24A 1SGEI 1MT1A 2N17A 2KMOA 2LUYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2CJS C;  2A20 A; 
#chains in the Genus database with same CATH topology
 2BUS A;  2N52 A;  1XA6 A;  2OU2 A;  2SGP I;  3HH2 C;  3VDU A;  2PQ8 A;  4SGB I;  3SEK C;  2E73 A;  3TO7 A;  3UEJ A;  4AML A;  1YTP A;  2L7X A;  3QTL D;  1CT2 I;  1DS2 I;  2OD1 A;  2QQE A;  1XBT A;  1XX6 A;  3OL0 A;  7WGA A;  2NU2 I;  1TBQ R;  1SGQ I;  2SGF I;  1MJA A;  3VE5 A;  2VRW B;  2YQP A;  1Y8F A;  2OZU A;  1FYB A;  1ULK A;  2NU3 I;  1V1H A;  1HPT A;  9WGA A;  3E59 A;  1MJ9 A;  2QQD A;  3GOX A;  4MPI A;  1CSO I;  2LB7 A;  1NUB A;  1LR7 A;  2SGD I;  3UEY A;  2X52 A;  2JW6 A;  2ENN A;  2ORV A;  1CHO I;  2ORW A;  4E1R A;  2GVI A;  2CJS C;  5J8C A;  1SGD I;  1AN1 I;  1K7V A;  2DIP A;  2JYY A;  2QPO A;  1WTJ A;  1X74 A;  2SGE I;  1CGJ I;  1Z2I A;  5J8F A;  3BJI A;  1OMU A;  2KMQ A;  1LR9 A;  4UXH A;  3TO6 A;  5CCL A;  3OVO A;  2WVJ A;  5FUV A;  5CCM A;  2K9H A;  1Z7K B;  2F3C I;  1HEV A;  2Y0M A;  1UVG A;  2KMR A;  1UUC A;  2NU1 I;  5FUX A;  1R0R I;  1M8C A;  1CT4 I;  1PTR A;  1MJB A;  2LEO A;  2V1C A;  1LR8 A;  2FNF X;  3QAH A;  5DAE A;  5FUY A;  1WGT A;  4UXJ A;  3UOE A;  4E1P A;  2WCY A;  1OYV I;  5E3R A;  1OVO A;  2A20 A;  3TJQ A;  1W3S A;  3R5A A;  4JCV E;  2J87 A;  1YU6 C;  4DNC A;  2UZ3 A;  1SGN I;  1Q9B A;  2CWH A;  1TOT A;  4FKD A;  1K7T A;  1CT0 I;  2B0U C;  4WP4 A;  2GKT I;  1HJA I;  5HI7 A;  2NU0 I;  2V1C C;  2KCX A;  2V53 A;  3FSX A;  1N13 A;  2XRC A;  3KY9 A;  3PDN A;  5EX0 A;  1H0Z A;  5E3Q A;  2L8E A;  5EX3 A;  3B4V C;  3R5B A;  4L9M A;  2KMP A;  1TUS A;  1SGP I;  1S20 A;  2DB6 A;  1NXU A;  1U5K A;  1TBO A;  2ARP F;  2N71 A;  1HDL A;  1ULM A;  3D00 A;  2UVO A;  2X3T A;  1BUS A;  1PPF I;  3UGD A;  1BMO A;  1CE3 A;  1RFH A;  1WGC A;  1KBE A;  2B8T A;  3QWP A;  3OXL A;  2GKR I;  1M8B A;  1CGI I;  1SGY I;  3MEK A;  3E2I A;  3RU0 A;  3FC3 A;  1TIH A;  1TBN A;  5JHW C;  3TOB A;  1PJU A;  3TO9 A;  1P9Z A;  2GIV A;  2RIJ A;  2M5X A;  1IY6 A;  1SGR I;  1FY7 A;  1ULN A;  1UHA A;  2DKV A;  3FSY A;  1P9G A;  2ENZ A;  1FAR A;  2NU4 I;  1Y1C A;  1IY5 A;  1DS3 I;  2CWF A;  4B6D A;  1IW4 A;  3CXL A;  1TGS I;  3R5D A;  1FAQ A;  1UVF A;  2ELI A;  3UGI A;  2YUU A;  4GI3 C;  1X4S A;  2OVO A;  1KBF A;  3OXF A;  1W4R A;  3VDP A;  5HQ8 A;  2QQ0 A;  1TBR R;  1Y1B A;  2RC4 A;  2P6A C;  3SGQ I;  3SGB I;  4UXI A;  1K7U A;  1VDD A;  2JZM A;  2ROW A;  2SGQ I;  1OMT A;  2ODD A;  2JA1 A;  1PTQ A;  3UFF A;  2CWG A;  5E3P A;  3OXG A;  2GKV A;  1WKX A;  2E5R A;  2ERW A;  2JXD A;  2N1A B;  2QQC A;  3TOA A;  3UGL A;  4HGU A;  1V1I A;  1TUR A;  4OVO A;  3R5C A;  1PCE A;  1R79 A;  1KMA A;  2W0T A;  5FUW A;  2J9R A;  2WGC A;  4A24 A;  1SGE I;  1MT1 A;  2N17 A;  2KMO A;  2LUY A; 
#chains in the Genus database with same CATH homology
 2BUS A;  2N52 A;  1XA6 A;  2SGP I;  3HH2 C;  3VDU A;  4SGB I;  3SEK C;  2E73 A;  3UEJ A;  1YTP A;  2L7X A;  3QTL D;  1CT2 I;  1DS2 I;  2OD1 A;  2QQE A;  1XBT A;  1XX6 A;  3OL0 A;  2NU2 I;  1TBQ R;  1SGQ I;  2SGF I;  3VE5 A;  2VRW B;  2YQP A;  1Y8F A;  1FYB A;  2NU3 I;  1V1H A;  1HPT A;  3E59 A;  2QQD A;  3GOX A;  1CSO I;  1NUB A;  1LR7 A;  2SGD I;  3UEY A;  2JW6 A;  2ENN A;  2ORV A;  1CHO I;  2ORW A;  2GVI A;  2CJS C;  1SGD I;  1AN1 I;  2DIP A;  2QPO A;  2JYY A;  1X74 A;  2SGE I;  1CGJ I;  3BJI A;  1OMU A;  2KMQ A;  1LR9 A;  4UXH A;  5CCL A;  3OVO A;  2WVJ A;  5FUV A;  5CCM A;  2K9H A;  1Z7K B;  2F3C I;  1UVG A;  2KMR A;  1UUC A;  2NU1 I;  5FUX A;  1R0R I;  1M8C A;  1CT4 I;  1PTR A;  2LEO A;  2V1C A;  4E1R A;  1LR8 A;  2FNF X;  5DAE A;  4E1P A;  5FUY A;  4UXJ A;  2WCY A;  1OYV I;  1OVO A;  2A20 A;  3TJQ A;  1W3S A;  4JCV E;  2J87 A;  1YU6 C;  2UZ3 A;  1SGN I;  1TOT A;  4FKD A;  1CT0 I;  2B0U C;  2GKT I;  1HJA I;  5HI7 A;  2NU0 I;  2V1C C;  2KCX A;  2V53 A;  3KY9 A;  1N13 A;  2XRC A;  3PDN A;  5EX0 A;  1H0Z A;  2L8E A;  5EX3 A;  3B4V C;  4L9M A;  2KMP A;  1TUS A;  1SGP I;  2DB6 A;  1U5K A;  1TBO A;  2ARP F;  2N71 A;  1HDL A;  3D00 A;  1BUS A;  1PPF I;  3UGD A;  1BMO A;  1CE3 A;  1RFH A;  1KBE A;  2B8T A;  3QWP A;  3OXL A;  2GKR I;  1M8B A;  1CGI I;  1SGY I;  3MEK A;  3E2I A;  3RU0 A;  3FC3 A;  1TIH A;  1TBN A;  5JHW C;  1PJU A;  2M5X A;  1IY6 A;  1SGR I;  2ENZ A;  1FAR A;  2NU4 I;  1Y1C A;  1IY5 A;  1DS3 I;  4B6D A;  1IW4 A;  3CXL A;  1TGS I;  1FAQ A;  1UVF A;  2ELI A;  3UGI A;  2YUU A;  4GI3 C;  1X4S A;  2OVO A;  1KBF A;  3OXF A;  1W4R A;  3VDP A;  5HQ8 A;  2QQ0 A;  1TBR R;  1Y1B A;  3SGQ I;  2P6A C;  3SGB I;  4UXI A;  2SGQ I;  1VDD A;  2JZM A;  2ROW A;  1OMT A;  2ODD A;  2JA1 A;  1PTQ A;  3UFF A;  3OXG A;  2GKV A;  2JXD A;  2E5R A;  2ERW A;  2N1A B;  2QQC A;  3UGL A;  4HGU A;  1V1I A;  1TUR A;  4OVO A;  1PCE A;  1R79 A;  1KMA A;  2W0T A;  5FUW A;  2J9R A;  4A24 A;  1SGE I;  1MT1 A;  2N17 A;  2KMO A;  2LUY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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