2B0UC

The structure of the follistatin:activin complex
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
288
structure length
287
Chain Sequence
GNCWLRQAKNGRCQVLYKTELSKEECCSTGRLSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSCN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords Inhibin beta A chain
publication title The Structure of the Follistatin:Activin Complex Reveals Antagonism of Both Type I and Type II Receptor Binding.
pubmed doi rcsb
source organism Homo sapiens
total genus 49
structure length 287
sequence length 288
chains with identical sequence D
ec nomenclature
pdb deposition date 2005-09-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF07648 Kazal_2 Kazal-type serine protease inhibitor domain
C PF09289 FOLN Follistatin/Osteonectin-like EGF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 2b0uC04
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 2b0uC03
3.30.60.250 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 2b0uC02
3.90.290.10 Alpha Beta Alpha-Beta Complex Extracellular Matrix Fibrillin TGF-beta binding (TB) domain 2b0uC01
1SGPI 2GKVA 2ARPF 2SGFI 1HPTA 1Y1BA 1APJA 2XRCA 1CT0I 1UUCA 3OVOA 1DS2I 3SGBI 1HDLA 2ERWA 2KMPA 1TURA 2N17A 1LR7A 2SGEI 1H0ZA 4GI3C 1SGNI 1YTPA 1N13A 2KMRA 1TUSA 5DAEA 4HGUA 5JHWC 1TGSI 1UZQA 2NU4I 2WCYA 2NU2I 1FYBA 2KCXA 2M5XA 1KSQA 1NUBA 1OMTA 2QQCA 2W86A 2LEOA 1PJUA 2SGDI 1LR9A 1CGJI 1MT1A 2SGQI 1CT4I 1CGII 1OYVI 1SGDI 2GKRI 1Z7KB 2KMOA 2SGPI 2NU1I 3TJQA 2P6AC 1SGRI 1OMUA 1CE3A 1IY6A 1OVOA 1HJAI 1M8CA 1AN1I 2NU0I 1UVFA 1BMOA 1YU6C 1UVGA 1TIHA 3QTLD 1CT2I 2GKTI 1SGEI 1DS3I 2NU3I 2OVOA 2JYYA 1IY5A 1LR8A 1PPFI 3SEKC 2B0UC 1BUSA 1UZJA 2V53A 2N71A 3B4VC 1KMAA 3HH2C 1R0RI 1IW4A 2QQDA 2JXDA 4OVOA 2F3CI 2KMQA 3SGQI 1TBQR 1CHOI 1Y1CA 1PCEA 4SGBI 1UZPA 1UZKA 1TBRR 2JZMA 1CSOI 2BUSA 1SGQI 2N52A 1SGYI 1M8BA
chains in the Genus database with same CATH superfamily
1R79A 1SGPI 2OD1A 2GKVA 2A20A 2ARPF 2SGFI 1HPTA 3MEKA 3UGLA 4WP4A 3VDPA 1XA6A 1Y1BA 1APJA 3UEJA 2XRCA 3E2IA 1CT0I 1UUCA 2JA1A 3OVOA 3VDUA 4L9MA 5E3PA 1DS2I 3SGBI 3QWPA 1HDLA 3TO7A 1TBNA 1X74A 2ERWA 2KMPA 5EX3A 1TURA 5CCMA 2W86A 2N17A 1LR7A 2VRWB 3UFFA 2SGEI 1H0ZA 1HEVA 4GI3C 1SGNI 3E59A 2V1CA 1TBOA 1YTPA 5FUWA 1N13A 2B8TA 2KMRA 1TUSA 5DAEA 4HGUA 2E5RA 2CWHA 2DKVA 3FSYA 2FNFX 3RU0A 5JHWC 1TGSI 3PDNA 1UZQA 4MPIA 3UEYA 3TOAA 2NU4I 2WCYA 2NU2I 1FYBA 1K7TA 2KCXA 2GVIA 2M5XA 3UOEA 1KSQA 2X52A 3UGDA 1ULMA 1NUBA 3OXGA 5FUXA 1OMTA 1P9GA 2QQCA 1XX6A 2W0TA 2ELIA 2CWFA 5E3QA 2UVOA 2YUUA 2JW6A 2LEOA 2RIJA 1NXUA 2L7XA 1PJUA 2WGCA 3TO6A 4A24A 5FUVA 9WGAA 5FUYA 2SGDI 2ODDA 1UHAA 1LR9A 3OXLA 1U5KA 1CGJI 1W3SA 1MT1A 2SGQI 1CT4I 1CGII 1OYVI 1KBFA 3R5DA 1SGDI 2GKRI 1Z7KB 4UXHA 2GIVA 2KMOA 2SGPI 2WVJA 1K7UA 2DB6A 2NU1I 1KBEA 1Z2IA 2CJSC 3TJQA 1W4RA 2P6AC 1XBTA 2DIPA 2E73A 1SGRI 1OMUA 1CE3A 1IY6A 4E1PA 1OVOA 1WGTA 1HJAI 2OU2A 2QQEA 3D00A 3OL0A 3TO9A 2OZUA 1FY7A 1M8CA 4JCVE 2YQPA 1AN1I 1WKXA 2NU0I 1RFHA 4B6DA 3R5CA 1UVFA 2J87A 1BMOA 2QQ0A 5J8FA 1YU6C 3CXLA 1UVGA 3R5AA 3UGIA 3FC3A 1TIHA 2QPOA 2RC4A 1FAQA 4DNCA 1ULKA 1V1HA 2ENNA 3FSXA 3QTLD 3GOXA 1MJAA 1CT2I 1V1IA 1Q9BA 2GKTI 3QAHA 1ULNA 1SGEI 1FARA 1DS3I 2L8EA 2NU3I 2OVOA 2JYYA 2X3TA 1IY5A 1S20A 2PQ8A 2ORWA 1LR8A 2N1AB 4UXIA 1PPFI 3SEKC 2B0UC 1BUSA 3VE5A 4UXJA 4FKDA 1UZJA 2V53A 2N71A 3B4VC 1KMAA 1VDDA 5E3RA 3HH2C 1R0RI 1Y8FA 2LB7A 1PTRA 3BJIA 1IW4A 4E1RA 2ENZA 2QQDA 2JXDA 1TOTA 1X4SA 2CWGA 4OVOA 5HI7A 1MJBA 2V1CC 2F3CI 2LUYA 2KMQA 1WTJA 5EX0A 3SGQI 1TBQR 1CHOI 1Y1CA 3TOBA 2Y0MA 5HQ8A 1PCEA 1WGCA 4SGBI 1UZPA 1UZKA 1MJ9A 1TBRR 2ORVA 2J9RA 2JZMA 1CSOI 2BUSA 1PTQA 1SGQI 5CCLA 1P9ZA 2N52A 3KY9A 2ROWA 7WGAA 2UZ3A 3R5BA 2K9HA 4AMLA 3OXFA 1SGYI 5J8CA 1M8BA 1K7VA
chains in the Genus database with same CATH topology
1R79A 1SGPI 2OD1A 2GKVA 2A20A 2ARPF 2SGFI 1HPTA 3MEKA 3UGLA 3VDPA 1XA6A 1Y1BA 1APJA 3UEJA 2XRCA 3E2IA 1CT0I 1UUCA 2JA1A 3OVOA 3VDUA 4L9MA 1DS2I 3SGBI 3QWPA 1HDLA 1TBNA 1X74A 2ERWA 2KMPA 5EX3A 1TURA 5CCMA 2N17A 1LR7A 2VRWB 3UFFA 2SGEI 1H0ZA 4GI3C 1SGNI 3E59A 2V1CA 1YTPA 1TBOA 5FUWA 1N13A 2B8TA 2KMRA 1TUSA 5DAEA 4HGUA 2E5RA 3RU0A 2FNFX 5JHWC 1TGSI 1UZQA 3UEYA 2NU4I 2WCYA 2NU2I 1FYBA 2KCXA 2GVIA 2M5XA 1KSQA 3UGDA 1NUBA 3OXGA 5FUXA 1OMTA 2QQCA 1XX6A 2W0TA 2ELIA 2YUUA 2JW6A 2LEOA 2W86A 2L7XA 1PJUA 4A24A 5FUVA 5FUYA 2SGDI 2ODDA 3OXLA 1LR9A 1U5KA 1CGJI 1W3SA 1MT1A 2SGQI 1CT4I 1CGII 1OYVI 1KBFA 1SGDI 2GKRI 1Z7KB 4UXHA 2KMOA 2SGPI 2WVJA 2DB6A 2NU1I 1KBEA 2CJSC 3TJQA 1W4RA 2P6AC 1XBTA 2DIPA 2E73A 1SGRI 1OMUA 1CE3A 1IY6A 4E1PA 1OVOA 1HJAI 2QQEA 3D00A 3OL0A 1M8CA 4JCVE 2YQPA 1AN1I 2NU0I 1RFHA 4B6DA 1UVFA 2J87A 1BMOA 2QQ0A 1YU6C 3CXLA 1UVGA 3UGIA 3FC3A 1TIHA 2QPOA 1FAQA 1V1HA 2ENNA 3QTLD 3GOXA 1V1IA 1CT2I 2GKTI 1SGEI 1FARA 1DS3I 2L8EA 2NU3I 2OVOA 2JYYA 1IY5A 2ORWA 1LR8A 2N1AB 4UXIA 1PPFI 3SEKC 2B0UC 1BUSA 3VE5A 4UXJA 4FKDA 1UZJA 2V53A 2N71A 3B4VC 1KMAA 1VDDA 3HH2C 1R0RI 1Y8FA 1PTRA 3BJIA 1IW4A 4E1RA 2ENZA 2QQDA 2JXDA 1TOTA 1X4SA 4OVOA 5HI7A 2V1CC 2F3CI 2LUYA 2KMQA 5EX0A 3SGQI 5HQ8A 1TBQR 1CHOI 1Y1CA 1PCEA 4SGBI 1UZPA 1UZKA 1TBRR 2ORVA 2J9RA 2JZMA 1CSOI 2BUSA 1PTQA 1SGQI 5CCLA 2N52A 3KY9A 2ROWA 2UZ3A 2K9HA 3OXFA 1SGYI 1M8BA 3PDNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SGP I;  2GKV A;  2ARP F;  2SGF I;  1HPT A;  1Y1B A;  1APJ A;  2XRC A;  1CT0 I;  1UUC A;  3OVO A;  1DS2 I;  3SGB I;  1HDL A;  2ERW A;  2KMP A;  1TUR A;  2N17 A;  1LR7 A;  2SGE I;  1H0Z A;  4GI3 C;  1SGN I;  1YTP A;  1N13 A;  2KMR A;  1TUS A;  5DAE A;  4HGU A;  5JHW C;  1TGS I;  1UZQ A;  2NU4 I;  2WCY A;  2NU2 I;  1FYB A;  2KCX A;  2M5X A;  1KSQ A;  1NUB A;  1OMT A;  2QQC A;  2W86 A;  2LEO A;  1PJU A;  2SGD I;  1LR9 A;  1CGJ I;  1MT1 A;  2SGQ I;  1CT4 I;  1CGI I;  1OYV I;  1SGD I;  2GKR I;  1Z7K B;  2KMO A;  2SGP I;  2NU1 I;  3TJQ A;  2P6A C;  1SGR I;  1OMU A;  1CE3 A;  1IY6 A;  1OVO A;  1HJA I;  1M8C A;  1AN1 I;  2NU0 I;  1UVF A;  1BMO A;  1YU6 C;  1UVG A;  1TIH A;  3QTL D;  1CT2 I;  2GKT I;  1SGE I;  1DS3 I;  2NU3 I;  2OVO A;  2JYY A;  1IY5 A;  1LR8 A;  1PPF I;  3SEK C;  2B0U C;  1BUS A;  1UZJ A;  2V53 A;  2N71 A;  3B4V C;  1KMA A;  3HH2 C;  1R0R I;  1IW4 A;  2QQD A;  2JXD A;  4OVO A;  2F3C I;  2KMQ A;  3SGQ I;  1TBQ R;  1CHO I;  1Y1C A;  1PCE A;  4SGB I;  1UZP A;  1UZK A;  1TBR R;  2JZM A;  1CSO I;  2BUS A;  1SGQ I;  2N52 A;  1SGY I;  1M8B A; 
#chains in the Genus database with same CATH topology
 1R79 A;  1SGP I;  2OD1 A;  2GKV A;  2A20 A;  2ARP F;  2SGF I;  1HPT A;  3MEK A;  3UGL A;  4WP4 A;  3VDP A;  1XA6 A;  1Y1B A;  1APJ A;  3UEJ A;  2XRC A;  3E2I A;  1CT0 I;  1UUC A;  2JA1 A;  3OVO A;  3VDU A;  4L9M A;  5E3P A;  1DS2 I;  3SGB I;  3QWP A;  1HDL A;  3TO7 A;  1TBN A;  1X74 A;  2ERW A;  2KMP A;  5EX3 A;  1TUR A;  5CCM A;  2W86 A;  2N17 A;  1LR7 A;  2VRW B;  3UFF A;  2SGE I;  1H0Z A;  1HEV A;  4GI3 C;  1SGN I;  3E59 A;  2V1C A;  1TBO A;  1YTP A;  5FUW A;  1N13 A;  2B8T A;  2KMR A;  1TUS A;  5DAE A;  4HGU A;  2E5R A;  2CWH A;  2DKV A;  3FSY A;  2FNF X;  3RU0 A;  5JHW C;  1TGS I;  3PDN A;  1UZQ A;  4MPI A;  3UEY A;  3TOA A;  2NU4 I;  2WCY A;  2NU2 I;  1FYB A;  1K7T A;  2KCX A;  2GVI A;  2M5X A;  3UOE A;  1KSQ A;  2X52 A;  3UGD A;  1ULM A;  1NUB A;  3OXG A;  5FUX A;  1OMT A;  1P9G A;  2QQC A;  1XX6 A;  2W0T A;  2ELI A;  2CWF A;  5E3Q A;  2UVO A;  2YUU A;  2JW6 A;  2LEO A;  2RIJ A;  1NXU A;  2L7X A;  1PJU A;  2WGC A;  3TO6 A;  4A24 A;  5FUV A;  9WGA A;  5FUY A;  2SGD I;  2ODD A;  1UHA A;  1LR9 A;  3OXL A;  1U5K A;  1CGJ I;  1W3S A;  1MT1 A;  2SGQ I;  1CT4 I;  1CGI I;  1OYV I;  1KBF A;  3R5D A;  1SGD I;  2GKR I;  1Z7K B;  4UXH A;  2GIV A;  2KMO A;  2SGP I;  2WVJ A;  1K7U A;  2DB6 A;  2NU1 I;  1KBE A;  1Z2I A;  2CJS C;  3TJQ A;  1W4R A;  2P6A C;  1XBT A;  2DIP A;  2E73 A;  1SGR I;  1OMU A;  1CE3 A;  1IY6 A;  4E1P A;  1OVO A;  1WGT A;  1HJA I;  2OU2 A;  2QQE A;  3D00 A;  3OL0 A;  3TO9 A;  2OZU A;  1FY7 A;  1M8C A;  4JCV E;  2YQP A;  1AN1 I;  1WKX A;  2NU0 I;  1RFH A;  4B6D A;  3R5C A;  1UVF A;  2J87 A;  1BMO A;  2QQ0 A;  5J8F A;  1YU6 C;  3CXL A;  1UVG A;  3R5A A;  3UGI A;  3FC3 A;  1TIH A;  2QPO A;  2RC4 A;  1FAQ A;  4DNC A;  1ULK A;  1V1H A;  2ENN A;  3FSX A;  3QTL D;  3GOX A;  1MJA A;  1CT2 I;  1V1I A;  1Q9B A;  2GKT I;  3QAH A;  1ULN A;  1SGE I;  1FAR A;  1DS3 I;  2L8E A;  2NU3 I;  2OVO A;  2JYY A;  2X3T A;  1IY5 A;  1S20 A;  2PQ8 A;  2ORW A;  1LR8 A;  2N1A B;  4UXI A;  1PPF I;  3SEK C;  2B0U C;  1BUS A;  3VE5 A;  4UXJ A;  4FKD A;  1UZJ A;  2V53 A;  2N71 A;  3B4V C;  1KMA A;  1VDD A;  5E3R A;  3HH2 C;  1R0R I;  1Y8F A;  2LB7 A;  1PTR A;  3BJI A;  1IW4 A;  4E1R A;  2ENZ A;  2QQD A;  2JXD A;  1TOT A;  1X4S A;  2CWG A;  4OVO A;  5HI7 A;  1MJB A;  2V1C C;  2F3C I;  2LUY A;  2KMQ A;  1WTJ A;  5EX0 A;  3SGQ I;  1TBQ R;  1CHO I;  1Y1C A;  3TOB A;  2Y0M A;  5HQ8 A;  1PCE A;  1WGC A;  4SGB I;  1UZP A;  1UZK A;  1MJ9 A;  1TBR R;  2ORV A;  2J9R A;  2JZM A;  1CSO I;  2BUS A;  1PTQ A;  1SGQ I;  5CCL A;  1P9Z A;  2N52 A;  3KY9 A;  2ROW A;  7WGA A;  2UZ3 A;  3R5B A;  2K9H A;  4AML A;  3OXF A;  1SGY I;  5J8C A;  1M8B A;  1K7V A; 
#chains in the Genus database with same CATH homology
 1R79 A;  1SGP I;  2OD1 A;  2GKV A;  2A20 A;  2ARP F;  2SGF I;  1HPT A;  3MEK A;  3UGL A;  3VDP A;  1XA6 A;  1Y1B A;  1APJ A;  3UEJ A;  2XRC A;  3E2I A;  1CT0 I;  1UUC A;  2JA1 A;  3OVO A;  3VDU A;  4L9M A;  1DS2 I;  3SGB I;  3QWP A;  1HDL A;  1TBN A;  1X74 A;  2ERW A;  2KMP A;  5EX3 A;  1TUR A;  5CCM A;  2N17 A;  1LR7 A;  2VRW B;  3UFF A;  2SGE I;  1H0Z A;  4GI3 C;  1SGN I;  3E59 A;  2V1C A;  1YTP A;  1TBO A;  5FUW A;  1N13 A;  2B8T A;  2KMR A;  1TUS A;  5DAE A;  4HGU A;  2E5R A;  3RU0 A;  2FNF X;  5JHW C;  1TGS I;  1UZQ A;  3UEY A;  2NU4 I;  2WCY A;  2NU2 I;  1FYB A;  2KCX A;  2GVI A;  2M5X A;  1KSQ A;  3UGD A;  1NUB A;  3OXG A;  5FUX A;  1OMT A;  2QQC A;  1XX6 A;  2W0T A;  2ELI A;  2YUU A;  2JW6 A;  2LEO A;  2W86 A;  2L7X A;  1PJU A;  4A24 A;  5FUV A;  5FUY A;  2SGD I;  2ODD A;  3OXL A;  1LR9 A;  1U5K A;  1CGJ I;  1W3S A;  1MT1 A;  2SGQ I;  1CT4 I;  1CGI I;  1OYV I;  1KBF A;  1SGD I;  2GKR I;  1Z7K B;  4UXH A;  2KMO A;  2SGP I;  2WVJ A;  2DB6 A;  2NU1 I;  1KBE A;  2CJS C;  3TJQ A;  1W4R A;  2P6A C;  1XBT A;  2DIP A;  2E73 A;  1SGR I;  1OMU A;  1CE3 A;  1IY6 A;  4E1P A;  1OVO A;  1HJA I;  2QQE A;  3D00 A;  3OL0 A;  1M8C A;  4JCV E;  2YQP A;  1AN1 I;  2NU0 I;  1RFH A;  4B6D A;  1UVF A;  2J87 A;  1BMO A;  2QQ0 A;  1YU6 C;  3CXL A;  1UVG A;  3UGI A;  3FC3 A;  1TIH A;  2QPO A;  1FAQ A;  1V1H A;  2ENN A;  3QTL D;  3GOX A;  1V1I A;  1CT2 I;  2GKT I;  1SGE I;  1FAR A;  1DS3 I;  2L8E A;  2NU3 I;  2OVO A;  2JYY A;  1IY5 A;  2ORW A;  1LR8 A;  2N1A B;  4UXI A;  1PPF I;  3SEK C;  2B0U C;  1BUS A;  3VE5 A;  4UXJ A;  4FKD A;  1UZJ A;  2V53 A;  2N71 A;  3B4V C;  1KMA A;  1VDD A;  3HH2 C;  1R0R I;  1Y8F A;  1PTR A;  3BJI A;  1IW4 A;  4E1R A;  2ENZ A;  2QQD A;  2JXD A;  1TOT A;  1X4S A;  4OVO A;  5HI7 A;  2V1C C;  2F3C I;  2LUY A;  2KMQ A;  5EX0 A;  3SGQ I;  5HQ8 A;  1TBQ R;  1CHO I;  1Y1C A;  1PCE A;  4SGB I;  1UZP A;  1UZK A;  1TBR R;  2ORV A;  2J9R A;  2JZM A;  1CSO I;  2BUS A;  1PTQ A;  1SGQ I;  5CCL A;  2N52 A;  3KY9 A;  2ROW A;  2UZ3 A;  2K9H A;  3OXF A;  1SGY I;  1M8B A;  3PDN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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