1LR9A

Structure of fs1, the heparin-binding domain of follistatin
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
73
structure length
73
Chain Sequence
ETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGKCK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
pubmed doi rcsb
molecule tags Hormone/growth factor
source organism Rattus norvegicus
molecule keywords Follistatin
total genus 11
structure length 73
sequence length 73
ec nomenclature
pdb deposition date 2002-05-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07648 Kazal_2 Kazal-type serine protease inhibitor domain
A PF09289 FOLN Follistatin/Osteonectin-like EGF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 1lr9A00
1Y1BA 1LR9A 1SGQI 1UVGA 3OVOA 1SGYI 2JZMA 2JYYA 4OVOA 1OMUA 2ARPF 2P6AC 1N13A 1CT2I 2OVOA 1PCEA 4GI3C 5JHWC 1LR8A 1OMTA 1IW4A 3SGQI 2SGPI 2KMRA 1HDLA 1KMAA 2LEOA 1SGNI 2KMOA 2WCYA 2B0UC 1OVOA 1CSOI 1CT0I 1SGRI 2NU3I 1CGJI 3HH2C 1DS2I 4HGUA 1HJAI 1M8CA 1TGSI 2QQCA 4SGBI 2V53A 2BUSA 1MT1A 2GKVA 1FYBA 2GKRI 1BMOA 1DS3I 1Y1CA 2KCXA 3B4VC 1BUSA 1CT4I 2SGEI 1OYVI 2N52A 1H0ZA 2N17A 1R0RI 2GKTI 1TIHA 1AN1I 1CE3A 3TJQA 2JXDA 1TUSA 2XRCA 1PPFI 1YTPA 2SGQI 2ERWA 1IY5A 1Z7KB 1HPTA 1NUBA 2N71A 1CGII 2SGDI 3SGBI 2QQDA 1TBRR 3SEKC 2NU4I 5DAEA 1UUCA 2NU1I 1PJUA 1TBQR 1YU6C 1IY6A 3QTLD 1LR7A 2SGFI 1SGDI 1SGPI 2NU0I 2KMQA 1CHOI 2M5XA 1TURA 2NU2I 2F3CI 1M8BA 1UVFA 2KMPA 1SGEI
chains in the Genus database with same CATH superfamily
3OXGA 2E73A 2CJSC 1VDDA 3TOAA 7WGAA 1Y1BA 2GIVA 2CWGA 1LR9A 2RIJA 1SGQI 1UVGA 2N1AB 3OVOA 1ULMA 5J8CA 1SGYI 2JZMA 2JYYA 2ROWA 2X52A 5FUWA 4OVOA 3FC3A 1OMUA 2ARPF 2GVIA 2P6AC 1N13A 3UEJA 1CT2I 2DB6A 1PCEA 2FNFX 2OVOA 3R5AA 1LR8A 4GI3C 3UFFA 2WGCA 3VDPA 5JHWC 1OMTA 2LUYA 1IW4A 1K7UA 1ULKA 2B8TA 2DKVA 3BJIA 3R5DA 3SGQI 2SGPI 1KBFA 2LB7A 2KMRA 1HDLA 1KMAA 2LEOA 1SGNI 2KMOA 2WCYA 2B0UC 4UXIA 1OVOA 1CSOI 1CT0I 1SGRI 1XBTA 2NU3I 2QQEA 4WP4A 1P9GA 1CGJI 3E59A 2CWFA 3HH2C 1DS2I 4HGUA 2ELIA 2UVOA 3VDUA 2A20A 1HJAI 1M8CA 1TGSI 2OU2A 2QQCA 3CXLA 4SGBI 3UOEA 4E1RA 3E2IA 5CCMA 2PQ8A 3OL0A 2L7XA 2UZ3A 2X3TA 1WTJA 5HI7A 2V53A 3R5BA 2BUSA 4FKDA 1MT1A 2YUUA 1FAQA 5FUVA 1U5KA 2GKVA 2GKRI 1BMOA 1FYBA 9WGAA 1DS3I 1TBOA 1Y1CA 5FUYA 2W0TA 4MPIA 2ORWA 2V1CA 3QAHA 4AMLA 2KCXA 2VRWB 3B4VC 3R5CA 1BUSA 1CT4I 1W3SA 2SGEI 3FSYA 1OYVI 2K9HA 5E3RA 1WGCA 2RC4A 3MEKA 4L9MA 3TO6A 1Z2IA 3RU0A 3UGDA 2DIPA 2N52A 5CCLA 1MJ9A 3OXLA 1H0ZA 2N17A 1PTQA 1R0RI 1MJBA 2GKTI 2JA1A 4DNCA 1TIHA 5EX3A 1S20A 1V1IA 1X74A 1HEVA 5FUXA 2YQPA 5J8FA 1V1HA 1AN1I 1FARA 3PDNA 1W4RA 1CE3A 3TJQA 2JXDA 1FY7A 1TUSA 2OZUA 2XRCA 1R79A 3TO9A 1PPFI 2L8EA 2WVJA 2E5RA 1Q9BA 3TOBA 1XX6A 3KY9A 4JCVE 1YTPA 2OD1A 5HQ8A 2SGQI 1WKXA 4B6DA 1Y8FA 1TBNA 1UHAA 2ERWA 3QWPA 5E3PA 1NXUA 1IY5A 4E1PA 5EX0A 1Z7KB 1RFHA 1X4SA 1HPTA 2CWHA 1NUBA 2N71A 1XA6A 2J87A 1CGII 2SGDI 3SGBI 4A24A 3TO7A 4UXHA 2ENZA 1P9ZA 1PTRA 2ENNA 1TBRR 1KBEA 2QPOA 2QQDA 5E3QA 3SEKC 2J9RA 2NU4I 5DAEA 1UUCA 3D00A 2NU1I 3GOXA 1PJUA 1TBQR 1WGTA 1ULNA 1YU6C 1IY6A 3QTLD 1LR7A 1K7VA 2Y0MA 2ODDA 3UEYA 1K7TA 2SGFI 3VE5A 3FSXA 1SGDI 2ORVA 1SGPI 1TOTA 2KMQA 2NU0I 1CHOI 3OXFA 2M5XA 3UGIA 1TURA 2NU2I 2F3CI 3UGLA 4UXJA 1MJAA 1M8BA 1UVFA 2JW6A 2KMPA 2V1CC 2QQ0A 1SGEI
chains in the Genus database with same CATH topology
3OXGA 2E73A 2CJSC 1VDDA 1Y1BA 1LR9A 1SGQI 1UVGA 2N1AB 3OVOA 1SGYI 2JZMA 2JYYA 2ROWA 5FUWA 3FC3A 4OVOA 1OMUA 2ARPF 2GVIA 2P6AC 1N13A 3UEJA 1CT2I 2DB6A 1PCEA 2FNFX 2OVOA 4GI3C 1LR8A 3UFFA 3VDPA 5JHWC 1OMTA 2LUYA 1IW4A 2B8TA 3BJIA 3SGQI 2SGPI 1KBFA 2KMRA 1HDLA 1KMAA 2LEOA 1SGNI 2KMOA 2WCYA 2B0UC 4UXIA 1OVOA 1CSOI 1CT0I 1SGRI 1XBTA 2NU3I 2QQEA 1CGJI 3E59A 3HH2C 1DS2I 4HGUA 2ELIA 3VDUA 2A20A 1HJAI 1M8CA 1TGSI 2QQCA 3CXLA 4SGBI 4E1RA 5CCMA 3E2IA 3OL0A 2L7XA 2UZ3A 5HI7A 2V53A 4FKDA 2BUSA 1MT1A 2YUUA 1FAQA 5FUVA 1U5KA 2GKVA 2GKRI 1BMOA 1FYBA 1DS3I 1TBOA 1Y1CA 5FUYA 2W0TA 2ORWA 2V1CA 2KCXA 2VRWB 3B4VC 1BUSA 1CT4I 1W3SA 2SGEI 1OYVI 2K9HA 3MEKA 4L9MA 3UGDA 3RU0A 2DIPA 2N52A 5CCLA 3OXLA 1H0ZA 2N17A 1PTQA 1R0RI 2GKTI 2JA1A 1TIHA 5EX3A 1V1IA 1X74A 5FUXA 2YQPA 1V1HA 1AN1I 1FARA 3PDNA 1W4RA 1CE3A 3TJQA 2JXDA 1TUSA 2XRCA 1R79A 1PPFI 2L8EA 2WVJA 2E5RA 1XX6A 3KY9A 4JCVE 1YTPA 2OD1A 5HQ8A 2SGQI 4B6DA 1Y8FA 1TBNA 2ERWA 3QWPA 1IY5A 4E1PA 5EX0A 1Z7KB 1RFHA 1X4SA 1HPTA 1NUBA 2N71A 1XA6A 2J87A 1CGII 2SGDI 3SGBI 4A24A 4UXHA 2ENZA 1PTRA 2ENNA 1TBRR 1KBEA 2QPOA 2QQDA 3SEKC 2J9RA 2NU4I 5DAEA 1UUCA 3D00A 2NU1I 3GOXA 1PJUA 1TBQR 1YU6C 1IY6A 3QTLD 1LR7A 2ODDA 3UEYA 2SGFI 3VE5A 1SGDI 2ORVA 1SGPI 1TOTA 2KMQA 2NU0I 1CHOI 3OXFA 2M5XA 3UGIA 1TURA 2NU2I 2F3CI 3UGLA 4UXJA 2JW6A 1M8BA 1UVFA 2KMPA 2V1CC 2QQ0A 1SGEI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Y1B A;  1LR9 A;  1SGQ I;  1UVG A;  3OVO A;  1SGY I;  2JZM A;  2JYY A;  4OVO A;  1OMU A;  2ARP F;  2P6A C;  1N13 A;  1CT2 I;  2OVO A;  1PCE A;  4GI3 C;  5JHW C;  1LR8 A;  1OMT A;  1IW4 A;  3SGQ I;  2SGP I;  2KMR A;  1HDL A;  1KMA A;  2LEO A;  1SGN I;  2KMO A;  2WCY A;  2B0U C;  1OVO A;  1CSO I;  1CT0 I;  1SGR I;  2NU3 I;  1CGJ I;  3HH2 C;  1DS2 I;  4HGU A;  1HJA I;  1M8C A;  1TGS I;  2QQC A;  4SGB I;  2V53 A;  2BUS A;  1MT1 A;  2GKV A;  1FYB A;  2GKR I;  1BMO A;  1DS3 I;  1Y1C A;  2KCX A;  3B4V C;  1BUS A;  1CT4 I;  2SGE I;  1OYV I;  2N52 A;  1H0Z A;  2N17 A;  1R0R I;  2GKT I;  1TIH A;  1AN1 I;  1CE3 A;  3TJQ A;  2JXD A;  1TUS A;  2XRC A;  1PPF I;  1YTP A;  2SGQ I;  2ERW A;  1IY5 A;  1Z7K B;  1HPT A;  1NUB A;  2N71 A;  1CGI I;  2SGD I;  3SGB I;  2QQD A;  1TBR R;  3SEK C;  2NU4 I;  5DAE A;  1UUC A;  2NU1 I;  1PJU A;  1TBQ R;  1YU6 C;  1IY6 A;  3QTL D;  1LR7 A;  2SGF I;  1SGD I;  1SGP I;  2NU0 I;  2KMQ A;  1CHO I;  2M5X A;  1TUR A;  2NU2 I;  2F3C I;  1M8B A;  1UVF A;  2KMP A;  1SGE I; 
#chains in the Genus database with same CATH topology
 3OXG A;  2E73 A;  2CJS C;  1VDD A;  3TOA A;  7WGA A;  1Y1B A;  2GIV A;  2CWG A;  1LR9 A;  2RIJ A;  1SGQ I;  1UVG A;  2N1A B;  3OVO A;  1ULM A;  5J8C A;  1SGY I;  2JZM A;  2JYY A;  2ROW A;  2X52 A;  5FUW A;  4OVO A;  3FC3 A;  1OMU A;  2ARP F;  2GVI A;  2P6A C;  1N13 A;  3UEJ A;  1CT2 I;  2DB6 A;  1PCE A;  2FNF X;  2OVO A;  3R5A A;  1LR8 A;  4GI3 C;  3UFF A;  2WGC A;  3VDP A;  5JHW C;  1OMT A;  2LUY A;  1IW4 A;  1K7U A;  1ULK A;  2B8T A;  2DKV A;  3BJI A;  3R5D A;  3SGQ I;  2SGP I;  1KBF A;  2LB7 A;  2KMR A;  1HDL A;  1KMA A;  2LEO A;  1SGN I;  2KMO A;  2WCY A;  2B0U C;  4UXI A;  1OVO A;  1CSO I;  1CT0 I;  1SGR I;  1XBT A;  2NU3 I;  2QQE A;  4WP4 A;  1P9G A;  1CGJ I;  3E59 A;  2CWF A;  3HH2 C;  1DS2 I;  4HGU A;  2ELI A;  2UVO A;  3VDU A;  2A20 A;  1HJA I;  1M8C A;  1TGS I;  2OU2 A;  2QQC A;  3CXL A;  4SGB I;  3UOE A;  4E1R A;  3E2I A;  5CCM A;  2PQ8 A;  3OL0 A;  2L7X A;  2UZ3 A;  2X3T A;  1WTJ A;  5HI7 A;  2V53 A;  3R5B A;  2BUS A;  4FKD A;  1MT1 A;  2YUU A;  1FAQ A;  5FUV A;  1U5K A;  2GKV A;  2GKR I;  1BMO A;  1FYB A;  9WGA A;  1DS3 I;  1TBO A;  1Y1C A;  5FUY A;  2W0T A;  4MPI A;  2ORW A;  2V1C A;  3QAH A;  4AML A;  2KCX A;  2VRW B;  3B4V C;  3R5C A;  1BUS A;  1CT4 I;  1W3S A;  2SGE I;  3FSY A;  1OYV I;  2K9H A;  5E3R A;  1WGC A;  2RC4 A;  3MEK A;  4L9M A;  3TO6 A;  1Z2I A;  3RU0 A;  3UGD A;  2DIP A;  2N52 A;  5CCL A;  1MJ9 A;  3OXL A;  1H0Z A;  2N17 A;  1PTQ A;  1R0R I;  1MJB A;  2GKT I;  2JA1 A;  4DNC A;  1TIH A;  5EX3 A;  1S20 A;  1V1I A;  1X74 A;  1HEV A;  5FUX A;  2YQP A;  5J8F A;  1V1H A;  1AN1 I;  1FAR A;  3PDN A;  1W4R A;  1CE3 A;  3TJQ A;  2JXD A;  1FY7 A;  1TUS A;  2OZU A;  2XRC A;  1R79 A;  3TO9 A;  1PPF I;  2L8E A;  2WVJ A;  2E5R A;  1Q9B A;  3TOB A;  1XX6 A;  3KY9 A;  4JCV E;  1YTP A;  2OD1 A;  5HQ8 A;  2SGQ I;  1WKX A;  4B6D A;  1Y8F A;  1TBN A;  1UHA A;  2ERW A;  3QWP A;  5E3P A;  1NXU A;  1IY5 A;  4E1P A;  5EX0 A;  1Z7K B;  1RFH A;  1X4S A;  1HPT A;  2CWH A;  1NUB A;  2N71 A;  1XA6 A;  2J87 A;  1CGI I;  2SGD I;  3SGB I;  4A24 A;  3TO7 A;  4UXH A;  2ENZ A;  1P9Z A;  1PTR A;  2ENN A;  1TBR R;  1KBE A;  2QPO A;  2QQD A;  5E3Q A;  3SEK C;  2J9R A;  2NU4 I;  5DAE A;  1UUC A;  3D00 A;  2NU1 I;  3GOX A;  1PJU A;  1TBQ R;  1WGT A;  1ULN A;  1YU6 C;  1IY6 A;  3QTL D;  1LR7 A;  1K7V A;  2Y0M A;  2ODD A;  3UEY A;  1K7T A;  2SGF I;  3VE5 A;  3FSX A;  1SGD I;  2ORV A;  1SGP I;  1TOT A;  2KMQ A;  2NU0 I;  1CHO I;  3OXF A;  2M5X A;  3UGI A;  1TUR A;  2NU2 I;  2F3C I;  3UGL A;  4UXJ A;  1MJA A;  1M8B A;  1UVF A;  2JW6 A;  2KMP A;  2V1C C;  2QQ0 A;  1SGE I; 
#chains in the Genus database with same CATH homology
 3OXG A;  2E73 A;  2CJS C;  1VDD A;  1Y1B A;  1LR9 A;  1SGQ I;  1UVG A;  2N1A B;  3OVO A;  1SGY I;  2JZM A;  2JYY A;  2ROW A;  5FUW A;  3FC3 A;  4OVO A;  1OMU A;  2ARP F;  2GVI A;  2P6A C;  1N13 A;  3UEJ A;  1CT2 I;  2DB6 A;  1PCE A;  2FNF X;  2OVO A;  4GI3 C;  1LR8 A;  3UFF A;  3VDP A;  5JHW C;  1OMT A;  2LUY A;  1IW4 A;  2B8T A;  3BJI A;  3SGQ I;  2SGP I;  1KBF A;  2KMR A;  1HDL A;  1KMA A;  2LEO A;  1SGN I;  2KMO A;  2WCY A;  2B0U C;  4UXI A;  1OVO A;  1CSO I;  1CT0 I;  1SGR I;  1XBT A;  2NU3 I;  2QQE A;  1CGJ I;  3E59 A;  3HH2 C;  1DS2 I;  4HGU A;  2ELI A;  3VDU A;  2A20 A;  1HJA I;  1M8C A;  1TGS I;  2QQC A;  3CXL A;  4SGB I;  4E1R A;  5CCM A;  3E2I A;  3OL0 A;  2L7X A;  2UZ3 A;  5HI7 A;  2V53 A;  4FKD A;  2BUS A;  1MT1 A;  2YUU A;  1FAQ A;  5FUV A;  1U5K A;  2GKV A;  2GKR I;  1BMO A;  1FYB A;  1DS3 I;  1TBO A;  1Y1C A;  5FUY A;  2W0T A;  2ORW A;  2V1C A;  2KCX A;  2VRW B;  3B4V C;  1BUS A;  1CT4 I;  1W3S A;  2SGE I;  1OYV I;  2K9H A;  3MEK A;  4L9M A;  3UGD A;  3RU0 A;  2DIP A;  2N52 A;  5CCL A;  3OXL A;  1H0Z A;  2N17 A;  1PTQ A;  1R0R I;  2GKT I;  2JA1 A;  1TIH A;  5EX3 A;  1V1I A;  1X74 A;  5FUX A;  2YQP A;  1V1H A;  1AN1 I;  1FAR A;  3PDN A;  1W4R A;  1CE3 A;  3TJQ A;  2JXD A;  1TUS A;  2XRC A;  1R79 A;  1PPF I;  2L8E A;  2WVJ A;  2E5R A;  1XX6 A;  3KY9 A;  4JCV E;  1YTP A;  2OD1 A;  5HQ8 A;  2SGQ I;  4B6D A;  1Y8F A;  1TBN A;  2ERW A;  3QWP A;  1IY5 A;  4E1P A;  5EX0 A;  1Z7K B;  1RFH A;  1X4S A;  1HPT A;  1NUB A;  2N71 A;  1XA6 A;  2J87 A;  1CGI I;  2SGD I;  3SGB I;  4A24 A;  4UXH A;  2ENZ A;  1PTR A;  2ENN A;  1TBR R;  1KBE A;  2QPO A;  2QQD A;  3SEK C;  2J9R A;  2NU4 I;  5DAE A;  1UUC A;  3D00 A;  2NU1 I;  3GOX A;  1PJU A;  1TBQ R;  1YU6 C;  1IY6 A;  3QTL D;  1LR7 A;  2ODD A;  3UEY A;  2SGF I;  3VE5 A;  1SGD I;  2ORV A;  1SGP I;  1TOT A;  2KMQ A;  2NU0 I;  1CHO I;  3OXF A;  2M5X A;  3UGI A;  1TUR A;  2NU2 I;  2F3C I;  3UGL A;  4UXJ A;  2JW6 A;  1M8B A;  1UVF A;  2KMP A;  2V1C C;  2QQ0 A;  1SGE I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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