1TBQR

Crystal structure of insect derived double domain kazal inhibitor rhodniin in complex with thrombin
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
103
structure length
103
Chain Sequence
EGGEPCACPHALHRVCGSDGETYSNPCTLNCAKFNGKPELVKVHDGPCEPDEDEDVCQECDGDEYKPVCGSDDITYDNNCRLECASISSSPGVELKHEGPCRT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Complex (serine protease/inhibitor)
source organism Rhodnius prolixus
publication title Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin.
pubmed rcsb
molecule keywords THROMBIN
total genus 24
structure length 103
sequence length 103
chains with identical sequence S
ec nomenclature
pdb deposition date 1995-03-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
R PF00050 Kazal_1 Kazal-type serine protease inhibitor domain
R PF07648 Kazal_2 Kazal-type serine protease inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 1tbqR02
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 1tbqR01
1DS2I 1OMTA 2N17A 2N52A 1FYBA 1SGDI 2M5XA 2F3CI 2KMRA 1SGRI 1OMUA 2QQDA 1M8BA 1Y1BA 1PCEA 1UUCA 1UVGA 3SEKC 1HDLA 2JZMA 1TBRR 2NU3I 1OVOA 1TBQR 2SGQI 1BMOA 1HJAI 1SGYI 2BUSA 1Y1CA 1OYVI 1TIHA 1UVFA 2KCXA 1CT2I 2P6AC 1YTPA 1PJUA 1PPFI 1M8CA 1SGNI 1SGQI 4HGUA 1YU6C 2NU4I 1CT4I 2SGFI 2ERWA 1CHOI 2GKTI 2SGPI 2LEOA 1BUSA 2GKVA 4GI3C 3OVOA 2GKRI 3QTLD 1IY5A 2XRCA 1NUBA 1LR9A 2N71A 1TGSI 1IY6A 1SGEI 1MT1A 3HH2C 2B0UC 1KMAA 5JHWC 2JYYA 2KMQA 4OVOA 1IW4A 1HPTA 2QQCA 1CGJI 2JXDA 3TJQA 2SGDI 2WCYA 3B4VC 2ARPF 5DAEA 1LR8A 1CT0I 1Z7KB 2OVOA 4SGBI 1CSOI 1TUSA 1CE3A 1R0RI 1H0ZA 1CGII 1LR7A 2KMPA 1AN1I 1DS3I 1N13A 2KMOA 2NU1I 2SGEI 2V53A 3SGQI 1SGPI 2NU2I 1TURA 2NU0I 3SGBI
chains in the Genus database with same CATH superfamily
1DS2I 1OMTA 2N17A 2N52A 4UXJA 1ULMA 4UXIA 5FUXA 1FYBA 1WGTA 1SGDI 2M5XA 1NXUA 2F3CI 2KMRA 1SGRI 3KY9A 1OMUA 4FKDA 5FUVA 1P9GA 1MJAA 2QQDA 1WTJA 5FUWA 1FY7A 1M8BA 2L7XA 1Y1BA 1PCEA 2WGCA 2DIPA 1KBFA 1UUCA 1UVGA 1TBNA 3SEKC 3UEYA 3UGIA 1HDLA 2JZMA 2CWHA 1TBRR 2NU3I 1OVOA 5FUYA 5EX3A 1TBQR 2ENNA 3OXLA 2SGQI 3UGLA 3R5DA 2CWGA 1W4RA 3GOXA 2V1CC 1BMOA 1HJAI 5CCLA 2A20A 2N1AB 1SGYI 2BUSA 9WGAA 2E73A 2GVIA 4WP4A 5CCMA 1MJ9A 3D00A 1Y1CA 3OXFA 1OYVI 1TIHA 1UVFA 3PDNA 2KCXA 1CT2I 3BJIA 2V1CA 5HQ8A 5J8CA 2LUYA 1S20A 3UOEA 2P6AC 1YTPA 1PJUA 5EX0A 3TOAA 1PPFI 1VDDA 5E3QA 1K7UA 1M8CA 1SGNI 3UGDA 3FC3A 2DB6A 1SGQI 4HGUA 2WVJA 2L8EA 2UVOA 1ULKA 1YU6C 2CWFA 4MPIA 2NU4I 2YQPA 2ODDA 5J8FA 3R5CA 2ORWA 1CT4I 2SGFI 2ERWA 1CHOI 1XBTA 2GKTI 2QQ0A 2SGPI 2CJSC 2X3TA 3FSYA 1UHAA 2LEOA 4L9MA 4AMLA 3R5BA 1BUSA 2E5RA 1W3SA 2GKVA 3OXGA 2DKVA 4GI3C 3TO7A 1KBEA 1FARA 3OVOA 4E1PA 1K7TA 2GKRI 2K9HA 2JA1A 2QPOA 2XRCA 2OZUA 1NUBA 1Y8FA 2RIJA 1LR9A 3CXLA 3QTLD 2N71A 1TGSI 2OD1A 3UFFA 1IY6A 1SGEI 3E59A 1MT1A 3HH2C 1U5KA 2RC4A 1FAQA 2GIVA 3QWPA 2B0UC 4B6DA 1KMAA 1X4SA 5JHWC 2JYYA 2KMQA 3TO9A 4OVOA 3E2IA 2OU2A 3RU0A 1K7VA 4A24A 3TOBA 1IW4A 1HPTA 2QQCA 2J9RA 1XX6A 1P9ZA 1CGJI 2JXDA 3TJQA 7WGAA 5E3RA 3OL0A 1R79A 2SGDI 2WCYA 3QAHA 3MEKA 3B4VC 4UXHA 1TOTA 2PQ8A 1RFHA 2QQEA 2ARPF 2B8TA 1IY5A 5DAEA 1V1HA 1LR8A 1CT0I 3FSXA 1X74A 1XA6A 1Z7KB 3R5AA 2OVOA 3VDUA 3VE5A 2ORVA 3VDPA 1ULNA 2LB7A 4SGBI 2UZ3A 3UEJA 1CSOI 1TUSA 2J87A 2X52A 1CE3A 1R0RI 1PTQA 1TBOA 1H0ZA 1Z2IA 1MJBA 2ELIA 1CGII 1LR7A 2KMPA 2VRWB 2ROWA 1AN1I 1PTRA 2YUUA 4JCVE 2ENZA 1DS3I 4E1RA 4DNCA 2JW6A 1WKXA 1N13A 2KMOA 2NU1I 2SGEI 2V53A 5E3PA 1SGPI 2NU2I 1WGCA 5HI7A 3SGQI 1Q9BA 1TURA 1HEVA 1V1IA 2NU0I 3TO6A 2W0TA 2FNFX 3SGBI 2Y0MA
chains in the Genus database with same CATH topology
1DS2I 1OMTA 2N17A 2N52A 4UXJA 4UXIA 5FUXA 1FYBA 1SGDI 2M5XA 2F3CI 2KMRA 1SGRI 3KY9A 1OMUA 4FKDA 5FUVA 2QQDA 1KBFA 5FUWA 1M8BA 2L7XA 1Y1BA 1PCEA 2DIPA 1UUCA 1UVGA 1TBNA 3SEKC 3UEYA 3UGIA 1HDLA 2JZMA 1TBRR 2NU3I 1OVOA 5FUYA 5EX3A 1TBQR 2ENNA 3OXLA 2SGQI 3UGLA 1W4RA 3GOXA 2V1CC 1BMOA 1HJAI 5CCLA 2A20A 2N1AB 1SGYI 2BUSA 2E73A 2GVIA 5CCMA 3D00A 1Y1CA 3OXFA 1OYVI 1TIHA 1UVFA 3PDNA 2KCXA 1CT2I 3BJIA 2V1CA 5HQ8A 2LUYA 2P6AC 1YTPA 1PJUA 5EX0A 1PPFI 1VDDA 1M8CA 1SGNI 3FC3A 2DB6A 1SGQI 4HGUA 2WVJA 2L8EA 1YU6C 2NU4I 2YQPA 2ODDA 2ORWA 1CT4I 2SGFI 2ERWA 1CHOI 1XBTA 2GKTI 2QQ0A 2SGPI 2CJSC 2LEOA 4L9MA 1BUSA 2E5RA 1W3SA 2GKVA 3OXGA 4GI3C 1KBEA 1FARA 3OVOA 4E1PA 2GKRI 2K9HA 2JA1A 2QPOA 2XRCA 3QTLD 1NUBA 1Y8FA 3CXLA 1LR9A 1IY5A 2N71A 1TGSI 2OD1A 3UFFA 1IY6A 1SGEI 3E59A 1MT1A 3HH2C 1U5KA 1FAQA 3QWPA 2B0UC 4B6DA 1KMAA 1X4SA 5JHWC 2JYYA 2KMQA 4OVOA 3E2IA 3RU0A 4A24A 1IW4A 1HPTA 2QQCA 2J9RA 1XX6A 1CGJI 2JXDA 3TJQA 3OL0A 1R79A 2SGDI 2WCYA 3MEKA 3B4VC 4UXHA 1TOTA 2QQEA 1RFHA 2ARPF 2B8TA 5DAEA 1V1HA 1LR8A 1CT0I 3VDUA 1X74A 1XA6A 1Z7KB 2OVOA 3VE5A 2ORVA 3VDPA 4SGBI 2UZ3A 3UEJA 1CSOI 1TUSA 2J87A 1CE3A 1R0RI 1PTQA 1TBOA 1H0ZA 2ELIA 1CGII 1LR7A 2KMPA 2VRWB 2ROWA 1AN1I 1PTRA 2YUUA 4JCVE 2ENZA 1DS3I 4E1RA 2JW6A 3UGDA 1N13A 2KMOA 2NU1I 2SGEI 2V53A 3SGQI 1SGPI 2NU2I 5HI7A 1TURA 1V1IA 2NU0I 2W0TA 2FNFX 3SGBI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DS2 I;  1OMT A;  2N17 A;  2N52 A;  1FYB A;  1SGD I;  2M5X A;  2F3C I;  2KMR A;  1SGR I;  1OMU A;  2QQD A;  1M8B A;  1Y1B A;  1PCE A;  1UUC A;  1UVG A;  3SEK C;  1HDL A;  2JZM A;  1TBR R;  2NU3 I;  1OVO A;  1TBQ R;  2SGQ I;  1BMO A;  1HJA I;  1SGY I;  2BUS A;  1Y1C A;  1OYV I;  1TIH A;  1UVF A;  2KCX A;  1CT2 I;  2P6A C;  1YTP A;  1PJU A;  1PPF I;  1M8C A;  1SGN I;  1SGQ I;  4HGU A;  1YU6 C;  2NU4 I;  1CT4 I;  2SGF I;  2ERW A;  1CHO I;  2GKT I;  2SGP I;  2LEO A;  1BUS A;  2GKV A;  4GI3 C;  3OVO A;  2GKR I;  3QTL D;  1IY5 A;  2XRC A;  1NUB A;  1LR9 A;  2N71 A;  1TGS I;  1IY6 A;  1SGE I;  1MT1 A;  3HH2 C;  2B0U C;  1KMA A;  5JHW C;  2JYY A;  2KMQ A;  4OVO A;  1IW4 A;  1HPT A;  2QQC A;  1CGJ I;  2JXD A;  3TJQ A;  2SGD I;  2WCY A;  3B4V C;  2ARP F;  5DAE A;  1LR8 A;  1CT0 I;  1Z7K B;  2OVO A;  4SGB I;  1CSO I;  1TUS A;  1CE3 A;  1R0R I;  1H0Z A;  1CGI I;  1LR7 A;  2KMP A;  1AN1 I;  1DS3 I;  1N13 A;  2KMO A;  2NU1 I;  2SGE I;  2V53 A;  3SGQ I;  1SGP I;  2NU2 I;  1TUR A;  2NU0 I;  3SGB I; 
#chains in the Genus database with same CATH topology
 1DS2 I;  1OMT A;  2N17 A;  2N52 A;  4UXJ A;  1ULM A;  4UXI A;  5FUX A;  1FYB A;  1WGT A;  1SGD I;  2M5X A;  1NXU A;  2F3C I;  2KMR A;  1SGR I;  3KY9 A;  1OMU A;  4FKD A;  5FUV A;  1P9G A;  1MJA A;  2QQD A;  1WTJ A;  5FUW A;  1FY7 A;  1M8B A;  2L7X A;  1Y1B A;  1PCE A;  2WGC A;  2DIP A;  1KBF A;  1UUC A;  1UVG A;  1TBN A;  3SEK C;  3UEY A;  3UGI A;  1HDL A;  2JZM A;  2CWH A;  1TBR R;  2NU3 I;  1OVO A;  5FUY A;  5EX3 A;  1TBQ R;  2ENN A;  3OXL A;  2SGQ I;  3UGL A;  3R5D A;  2CWG A;  1W4R A;  3GOX A;  2V1C C;  1BMO A;  1HJA I;  5CCL A;  2A20 A;  2N1A B;  1SGY I;  2BUS A;  9WGA A;  2E73 A;  2GVI A;  4WP4 A;  5CCM A;  1MJ9 A;  3D00 A;  1Y1C A;  3OXF A;  1OYV I;  1TIH A;  1UVF A;  3PDN A;  2KCX A;  1CT2 I;  3BJI A;  2V1C A;  5HQ8 A;  5J8C A;  2LUY A;  1S20 A;  3UOE A;  2P6A C;  1YTP A;  1PJU A;  5EX0 A;  3TOA A;  1PPF I;  1VDD A;  5E3Q A;  1K7U A;  1M8C A;  1SGN I;  3UGD A;  3FC3 A;  2DB6 A;  1SGQ I;  4HGU A;  2WVJ A;  2L8E A;  2UVO A;  1ULK A;  1YU6 C;  2CWF A;  4MPI A;  2NU4 I;  2YQP A;  2ODD A;  5J8F A;  3R5C A;  2ORW A;  1CT4 I;  2SGF I;  2ERW A;  1CHO I;  1XBT A;  2GKT I;  2QQ0 A;  2SGP I;  2CJS C;  2X3T A;  3FSY A;  1UHA A;  2LEO A;  4L9M A;  4AML A;  3R5B A;  1BUS A;  2E5R A;  1W3S A;  2GKV A;  3OXG A;  2DKV A;  4GI3 C;  3TO7 A;  1KBE A;  1FAR A;  3OVO A;  4E1P A;  1K7T A;  2GKR I;  2K9H A;  2JA1 A;  2QPO A;  2XRC A;  2OZU A;  1NUB A;  1Y8F A;  2RIJ A;  1LR9 A;  3CXL A;  3QTL D;  2N71 A;  1TGS I;  2OD1 A;  3UFF A;  1IY6 A;  1SGE I;  3E59 A;  1MT1 A;  3HH2 C;  1U5K A;  2RC4 A;  1FAQ A;  2GIV A;  3QWP A;  2B0U C;  4B6D A;  1KMA A;  1X4S A;  5JHW C;  2JYY A;  2KMQ A;  3TO9 A;  4OVO A;  3E2I A;  2OU2 A;  3RU0 A;  1K7V A;  4A24 A;  3TOB A;  1IW4 A;  1HPT A;  2QQC A;  2J9R A;  1XX6 A;  1P9Z A;  1CGJ I;  2JXD A;  3TJQ A;  7WGA A;  5E3R A;  3OL0 A;  1R79 A;  2SGD I;  2WCY A;  3QAH A;  3MEK A;  3B4V C;  4UXH A;  1TOT A;  2PQ8 A;  1RFH A;  2QQE A;  2ARP F;  2B8T A;  1IY5 A;  5DAE A;  1V1H A;  1LR8 A;  1CT0 I;  3FSX A;  1X74 A;  1XA6 A;  1Z7K B;  3R5A A;  2OVO A;  3VDU A;  3VE5 A;  2ORV A;  3VDP A;  1ULN A;  2LB7 A;  4SGB I;  2UZ3 A;  3UEJ A;  1CSO I;  1TUS A;  2J87 A;  2X52 A;  1CE3 A;  1R0R I;  1PTQ A;  1TBO A;  1H0Z A;  1Z2I A;  1MJB A;  2ELI A;  1CGI I;  1LR7 A;  2KMP A;  2VRW B;  2ROW A;  1AN1 I;  1PTR A;  2YUU A;  4JCV E;  2ENZ A;  1DS3 I;  4E1R A;  4DNC A;  2JW6 A;  1WKX A;  1N13 A;  2KMO A;  2NU1 I;  2SGE I;  2V53 A;  5E3P A;  1SGP I;  2NU2 I;  1WGC A;  5HI7 A;  3SGQ I;  1Q9B A;  1TUR A;  1HEV A;  1V1I A;  2NU0 I;  3TO6 A;  2W0T A;  2FNF X;  3SGB I;  2Y0M A; 
#chains in the Genus database with same CATH homology
 1DS2 I;  1OMT A;  2N17 A;  2N52 A;  4UXJ A;  4UXI A;  5FUX A;  1FYB A;  1SGD I;  2M5X A;  2F3C I;  2KMR A;  1SGR I;  3KY9 A;  1OMU A;  4FKD A;  5FUV A;  2QQD A;  1KBF A;  5FUW A;  1M8B A;  2L7X A;  1Y1B A;  1PCE A;  2DIP A;  1UUC A;  1UVG A;  1TBN A;  3SEK C;  3UEY A;  3UGI A;  1HDL A;  2JZM A;  1TBR R;  2NU3 I;  1OVO A;  5FUY A;  5EX3 A;  1TBQ R;  2ENN A;  3OXL A;  2SGQ I;  3UGL A;  1W4R A;  3GOX A;  2V1C C;  1BMO A;  1HJA I;  5CCL A;  2A20 A;  2N1A B;  1SGY I;  2BUS A;  2E73 A;  2GVI A;  5CCM A;  3D00 A;  1Y1C A;  3OXF A;  1OYV I;  1TIH A;  1UVF A;  3PDN A;  2KCX A;  1CT2 I;  3BJI A;  2V1C A;  5HQ8 A;  2LUY A;  2P6A C;  1YTP A;  1PJU A;  5EX0 A;  1PPF I;  1VDD A;  1M8C A;  1SGN I;  3FC3 A;  2DB6 A;  1SGQ I;  4HGU A;  2WVJ A;  2L8E A;  1YU6 C;  2NU4 I;  2YQP A;  2ODD A;  2ORW A;  1CT4 I;  2SGF I;  2ERW A;  1CHO I;  1XBT A;  2GKT I;  2QQ0 A;  2SGP I;  2CJS C;  2LEO A;  4L9M A;  1BUS A;  2E5R A;  1W3S A;  2GKV A;  3OXG A;  4GI3 C;  1KBE A;  1FAR A;  3OVO A;  4E1P A;  2GKR I;  2K9H A;  2JA1 A;  2QPO A;  2XRC A;  3QTL D;  1NUB A;  1Y8F A;  3CXL A;  1LR9 A;  1IY5 A;  2N71 A;  1TGS I;  2OD1 A;  3UFF A;  1IY6 A;  1SGE I;  3E59 A;  1MT1 A;  3HH2 C;  1U5K A;  1FAQ A;  3QWP A;  2B0U C;  4B6D A;  1KMA A;  1X4S A;  5JHW C;  2JYY A;  2KMQ A;  4OVO A;  3E2I A;  3RU0 A;  4A24 A;  1IW4 A;  1HPT A;  2QQC A;  2J9R A;  1XX6 A;  1CGJ I;  2JXD A;  3TJQ A;  3OL0 A;  1R79 A;  2SGD I;  2WCY A;  3MEK A;  3B4V C;  4UXH A;  1TOT A;  2QQE A;  1RFH A;  2ARP F;  2B8T A;  5DAE A;  1V1H A;  1LR8 A;  1CT0 I;  3VDU A;  1X74 A;  1XA6 A;  1Z7K B;  2OVO A;  3VE5 A;  2ORV A;  3VDP A;  4SGB I;  2UZ3 A;  3UEJ A;  1CSO I;  1TUS A;  2J87 A;  1CE3 A;  1R0R I;  1PTQ A;  1TBO A;  1H0Z A;  2ELI A;  1CGI I;  1LR7 A;  2KMP A;  2VRW B;  2ROW A;  1AN1 I;  1PTR A;  2YUU A;  4JCV E;  2ENZ A;  1DS3 I;  4E1R A;  2JW6 A;  3UGD A;  1N13 A;  2KMO A;  2NU1 I;  2SGE I;  2V53 A;  3SGQ I;  1SGP I;  2NU2 I;  5HI7 A;  1TUR A;  1V1I A;  2NU0 I;  2W0T A;  2FNF X;  3SGB I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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