1TGSI

Three-dimensional structure of the complex between pancreatic secretory inhibitor (kazal type) and trypsinogen at 1.8 angstroms resolution. structure solution, crystallographic refinement and preliminary structural interpretation
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
56
structure length
56
Chain Sequence
TSPQREATCTSEVSGCPKIYNPVCGTDGITYSNECVLCSENKKRQTPVLIQKSGPC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Three-dimensional structure of the complex between pancreatic secretory trypsin inhibitor (Kazal type) and trypsinogen at 1.8 A resolution. Structure solution, crystallographic refinement and preliminary structural interpretation.
pubmed doi rcsb
molecule tags Complex (proteinase/inhibitor)
source organism Bos taurus
molecule keywords TRYPSINOGEN
total genus 13
structure length 56
sequence length 56
ec nomenclature
pdb deposition date 1982-09-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00050 Kazal_1 Kazal-type serine protease inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 1tgsI00
2B0UC 2SGQI 2M5XA 2N71A 1SGRI 1YU6C 1NUBA 2V53A 1AN1I 1SGYI 1CT4I 2QQDA 2SGFI 1YTPA 1DS3I 4OVOA 1SGPI 1BMOA 1PPFI 1LR7A 1OMTA 2WCYA 1LR8A 1PJUA 1IY5A 1TGSI 1SGQI 1IY6A 2F3CI 1CGJI 1OMUA 1TURA 2XRCA 2LEOA 2JXDA 3QTLD 1Y1BA 1SGEI 1HPTA 2SGDI 3OVOA 1OVOA 1CSOI 2SGEI 1UVFA 1CE3A 1R0RI 3B4VC 1KMAA 1DS2I 1OYVI 4SGBI 1HJAI 2JYYA 1SGDI 1H0ZA 3HH2C 1LR9A 2KCXA 1FYBA 5DAEA 2KMOA 2GKRI 2NU2I 1HDLA 2GKVA 1IW4A 2N17A 1M8CA 1TIHA 1TUSA 1CT2I 2GKTI 4HGUA 2P6AC 1UUCA 1CT0I 2KMQA 4GI3C 2OVOA 2KMRA 2JZMA 1BUSA 1PCEA 2N52A 2NU0I 3SEKC 1TBQR 1Y1CA 1UVGA 2NU1I 1SGNI 2KMPA 5JHWC 1TBRR 1Z7KB 3SGQI 2QQCA 3SGBI 2ERWA 1CGII 2NU3I 2ARPF 1CHOI 1M8BA 3TJQA 1MT1A 1N13A 2NU4I 2SGPI 2BUSA
chains in the Genus database with same CATH superfamily
2L8EA 3OL0A 7WGAA 2B0UC 1KBEA 1PTRA 2V1CC 3R5AA 5E3PA 1MJAA 2ENNA 4JCVE 3R5BA 2SGQI 2N1AB 4WP4A 2M5XA 2N71A 4FKDA 1ULMA 2OD1A 4UXIA 1SGRI 3FSYA 2RIJA 1XX6A 5FUYA 2B8TA 3PDNA 1YU6C 2CWGA 1NUBA 1VDDA 1X4SA 1AN1I 2V53A 3E2IA 1SGYI 2CWFA 2E5RA 2ORWA 3UEJA 1CT4I 2QQDA 2QQEA 3UGLA 2SGFI 1YTPA 1DS3I 4OVOA 1SGPI 1BMOA 2UVOA 5J8CA 2QPOA 1PPFI 2LUYA 1LR7A 1OMTA 2WCYA 1LR8A 1K7UA 1PJUA 1WGTA 2ORVA 1IY5A 4UXHA 1XBTA 2WGCA 1SGQI 3FSXA 1IY6A 1S20A 2F3CI 2W0TA 3CXLA 3UFFA 1XA6A 3UOEA 1CGJI 1OMUA 1ULNA 1V1HA 1Z2IA 1TURA 5E3RA 9WGAA 2XRCA 2OU2A 2LEOA 2JXDA 5HI7A 3QTLD 1FARA 3UEYA 1Y1BA 1SGEI 1HPTA 2SGDI 2ELIA 2RC4A 3OVOA 2GVIA 1OVOA 1CSOI 3VE5A 2SGEI 2BUSA 1UVFA 1CE3A 2L7XA 1R0RI 3B4VC 1W4RA 1KMAA 1DS2I 1OYVI 4SGBI 1HJAI 2QQ0A 5CCMA 1Q9BA 2JYYA 4DNCA 5EX3A 1SGDI 3OXFA 1H0ZA 3HH2C 1LR9A 2KCXA 3R5DA 1FYBA 5DAEA 2KMOA 1HEVA 4UXJA 2CJSC 2DIPA 1RFHA 3E59A 3OXLA 2GKRI 2NU2I 1HDLA 1TBOA 1P9ZA 2ENZA 5EX0A 1FY7A 2JA1A 4MPIA 2FNFX 2UZ3A 2E73A 1X74A 2YUUA 3VDPA 2GKVA 3OXGA 2X52A 4A24A 3TO9A 1PTQA 2OZUA 1K7TA 1FAQA 3R5CA 5J8FA 1IW4A 1WGCA 2N17A 1K7VA 2GIVA 1M8CA 1TIHA 1TUSA 1CT2I 2GKTI 2LB7A 4E1RA 4HGUA 1U5KA 2J9RA 2P6AC 2Y0MA 1UUCA 1CT0I 2KMQA 4GI3C 2OVOA 1MJ9A 2KMRA 3BJIA 3TO7A 3VDUA 2JZMA 1BUSA 2VRWB 1PCEA 2N52A 1TOTA 3QAHA 4AMLA 1UHAA 2NU0I 3SEKC 2PQ8A 2ODDA 1Y8FA 3RU0A 1TBQR 1V1IA 1MJBA 3UGDA 1Y1CA 1UVGA 2J87A 2NU1I 1SGNI 2K9HA 5E3QA 2KMPA 5FUVA 5JHWC 1TBRR 1Z7KB 3SGQI 1NXUA 2QQCA 2WVJA 3SGBI 3GOXA 2ERWA 5FUWA 5FUXA 2X3TA 1ULKA 1CGII 1R79A 2JW6A 2NU3I 2DB6A 3KY9A 1WKXA 3MEKA 3QWPA 2ARPF 1W3SA 1TBNA 2YQPA 1WTJA 4B6DA 3TOAA 3UGIA 1CHOI 1M8BA 4E1PA 3TJQA 1P9GA 2A20A 5HQ8A 1MT1A 3TOBA 3D00A 2DKVA 1N13A 2ROWA 2CWHA 2NU4I 3FC3A 3TO6A 2V1CA 1KBFA 5CCLA 2SGPI 4L9MA 1TGSI
chains in the Genus database with same CATH topology
2L8EA 3OL0A 2B0UC 1KBEA 1PTRA 2V1CC 2ENNA 4JCVE 2SGQI 2N1AB 2M5XA 2N71A 4FKDA 2OD1A 4UXIA 1SGRI 1XX6A 5FUYA 2B8TA 3PDNA 1YU6C 1NUBA 1VDDA 1X4SA 1AN1I 2V53A 3E2IA 1SGYI 2ORWA 2E5RA 3UEJA 3UGLA 1CT4I 2QQDA 2QQEA 2SGFI 1YTPA 1DS3I 4OVOA 1SGPI 1BMOA 2QPOA 1PPFI 2LUYA 1LR7A 1OMTA 2WCYA 1LR8A 1PJUA 2ORVA 1IY5A 1TGSI 4UXHA 1XBTA 1SGQI 1IY6A 2F3CI 2W0TA 3CXLA 3UFFA 1XA6A 1CGJI 1OMUA 1V1HA 1TURA 2XRCA 2LEOA 2JXDA 5HI7A 3QTLD 1FARA 3UEYA 1Y1BA 1SGEI 1HPTA 2SGDI 2ELIA 3OVOA 3VE5A 2GVIA 1OVOA 1CSOI 2SGEI 1UVFA 1CE3A 2L7XA 1R0RI 3B4VC 1W4RA 1KMAA 1DS2I 1OYVI 4SGBI 1HJAI 2QQ0A 5CCMA 2JYYA 5EX3A 1SGDI 3OXFA 1H0ZA 3HH2C 1LR9A 2KCXA 1FYBA 5DAEA 2KMOA 4UXJA 2CJSC 2DIPA 1RFHA 3E59A 3OXLA 2GKRI 2NU2I 1HDLA 1TBOA 2ENZA 5EX0A 2JA1A 2FNFX 2UZ3A 2E73A 1X74A 2YUUA 3VDPA 2GKVA 3OXGA 4A24A 1PTQA 1FAQA 1IW4A 2N17A 1M8CA 1TIHA 1TUSA 1CT2I 2GKTI 4E1RA 4HGUA 1U5KA 2J9RA 2P6AC 1UUCA 1CT0I 2KMQA 4GI3C 2OVOA 2KMRA 3BJIA 3VDUA 2JZMA 1BUSA 2VRWB 1PCEA 2N52A 1TOTA 2NU0I 3SEKC 2ODDA 1Y8FA 3RU0A 1TBQR 1V1IA 3UGDA 1Y1CA 1UVGA 2J87A 2NU1I 1SGNI 2K9HA 2KMPA 5FUVA 5JHWC 1TBRR 1Z7KB 3SGQI 2QQCA 3GOXA 2WVJA 3SGBI 2ERWA 5FUWA 5FUXA 1CGII 1R79A 2JW6A 2NU3I 2DB6A 3KY9A 3MEKA 3QWPA 2ARPF 1W3SA 1TBNA 2YQPA 4B6DA 3UGIA 1CHOI 1M8BA 4E1PA 3TJQA 2A20A 5HQ8A 1MT1A 3D00A 1N13A 2ROWA 2NU4I 3FC3A 2V1CA 1KBFA 5CCLA 2SGPI 4L9MA 2BUSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2B0U C;  2SGQ I;  2M5X A;  2N71 A;  1SGR I;  1YU6 C;  1NUB A;  2V53 A;  1AN1 I;  1SGY I;  1CT4 I;  2QQD A;  2SGF I;  1YTP A;  1DS3 I;  4OVO A;  1SGP I;  1BMO A;  1PPF I;  1LR7 A;  1OMT A;  2WCY A;  1LR8 A;  1PJU A;  1IY5 A;  1TGS I;  1SGQ I;  1IY6 A;  2F3C I;  1CGJ I;  1OMU A;  1TUR A;  2XRC A;  2LEO A;  2JXD A;  3QTL D;  1Y1B A;  1SGE I;  1HPT A;  2SGD I;  3OVO A;  1OVO A;  1CSO I;  2SGE I;  1UVF A;  1CE3 A;  1R0R I;  3B4V C;  1KMA A;  1DS2 I;  1OYV I;  4SGB I;  1HJA I;  2JYY A;  1SGD I;  1H0Z A;  3HH2 C;  1LR9 A;  2KCX A;  1FYB A;  5DAE A;  2KMO A;  2GKR I;  2NU2 I;  1HDL A;  2GKV A;  1IW4 A;  2N17 A;  1M8C A;  1TIH A;  1TUS A;  1CT2 I;  2GKT I;  4HGU A;  2P6A C;  1UUC A;  1CT0 I;  2KMQ A;  4GI3 C;  2OVO A;  2KMR A;  2JZM A;  1BUS A;  1PCE A;  2N52 A;  2NU0 I;  3SEK C;  1TBQ R;  1Y1C A;  1UVG A;  2NU1 I;  1SGN I;  2KMP A;  5JHW C;  1TBR R;  1Z7K B;  3SGQ I;  2QQC A;  3SGB I;  2ERW A;  1CGI I;  2NU3 I;  2ARP F;  1CHO I;  1M8B A;  3TJQ A;  1MT1 A;  1N13 A;  2NU4 I;  2SGP I;  2BUS A; 
#chains in the Genus database with same CATH topology
 2L8E A;  3OL0 A;  7WGA A;  2B0U C;  1KBE A;  1PTR A;  2V1C C;  3R5A A;  5E3P A;  1MJA A;  2ENN A;  4JCV E;  3R5B A;  2SGQ I;  2N1A B;  4WP4 A;  2M5X A;  2N71 A;  4FKD A;  1ULM A;  2OD1 A;  4UXI A;  1SGR I;  3FSY A;  2RIJ A;  1XX6 A;  5FUY A;  2B8T A;  3PDN A;  1YU6 C;  2CWG A;  1NUB A;  1VDD A;  1X4S A;  1AN1 I;  2V53 A;  3E2I A;  1SGY I;  2CWF A;  2E5R A;  2ORW A;  3UEJ A;  1CT4 I;  2QQD A;  2QQE A;  3UGL A;  2SGF I;  1YTP A;  1DS3 I;  4OVO A;  1SGP I;  1BMO A;  2UVO A;  5J8C A;  2QPO A;  1PPF I;  2LUY A;  1LR7 A;  1OMT A;  2WCY A;  1LR8 A;  1K7U A;  1PJU A;  1WGT A;  2ORV A;  1IY5 A;  4UXH A;  1XBT A;  2WGC A;  1SGQ I;  3FSX A;  1IY6 A;  1S20 A;  2F3C I;  2W0T A;  3CXL A;  3UFF A;  1XA6 A;  3UOE A;  1CGJ I;  1OMU A;  1ULN A;  1V1H A;  1Z2I A;  1TUR A;  5E3R A;  9WGA A;  2XRC A;  2OU2 A;  2LEO A;  2JXD A;  5HI7 A;  3QTL D;  1FAR A;  3UEY A;  1Y1B A;  1SGE I;  1HPT A;  2SGD I;  2ELI A;  2RC4 A;  3OVO A;  2GVI A;  1OVO A;  1CSO I;  3VE5 A;  2SGE I;  2BUS A;  1UVF A;  1CE3 A;  2L7X A;  1R0R I;  3B4V C;  1W4R A;  1KMA A;  1DS2 I;  1OYV I;  4SGB I;  1HJA I;  2QQ0 A;  5CCM A;  1Q9B A;  2JYY A;  4DNC A;  5EX3 A;  1SGD I;  3OXF A;  1H0Z A;  3HH2 C;  1LR9 A;  2KCX A;  3R5D A;  1FYB A;  5DAE A;  2KMO A;  1HEV A;  4UXJ A;  2CJS C;  2DIP A;  1RFH A;  3E59 A;  3OXL A;  2GKR I;  2NU2 I;  1HDL A;  1TBO A;  1P9Z A;  2ENZ A;  5EX0 A;  1FY7 A;  2JA1 A;  4MPI A;  2FNF X;  2UZ3 A;  2E73 A;  1X74 A;  2YUU A;  3VDP A;  2GKV A;  3OXG A;  2X52 A;  4A24 A;  3TO9 A;  1PTQ A;  2OZU A;  1K7T A;  1FAQ A;  3R5C A;  5J8F A;  1IW4 A;  1WGC A;  2N17 A;  1K7V A;  2GIV A;  1M8C A;  1TIH A;  1TUS A;  1CT2 I;  2GKT I;  2LB7 A;  4E1R A;  4HGU A;  1U5K A;  2J9R A;  2P6A C;  2Y0M A;  1UUC A;  1CT0 I;  2KMQ A;  4GI3 C;  2OVO A;  1MJ9 A;  2KMR A;  3BJI A;  3TO7 A;  3VDU A;  2JZM A;  1BUS A;  2VRW B;  1PCE A;  2N52 A;  1TOT A;  3QAH A;  4AML A;  1UHA A;  2NU0 I;  3SEK C;  2PQ8 A;  2ODD A;  1Y8F A;  3RU0 A;  1TBQ R;  1V1I A;  1MJB A;  3UGD A;  1Y1C A;  1UVG A;  2J87 A;  2NU1 I;  1SGN I;  2K9H A;  5E3Q A;  2KMP A;  5FUV A;  5JHW C;  1TBR R;  1Z7K B;  3SGQ I;  1NXU A;  2QQC A;  2WVJ A;  3SGB I;  3GOX A;  2ERW A;  5FUW A;  5FUX A;  2X3T A;  1ULK A;  1CGI I;  1R79 A;  2JW6 A;  2NU3 I;  2DB6 A;  3KY9 A;  1WKX A;  3MEK A;  3QWP A;  2ARP F;  1W3S A;  1TBN A;  2YQP A;  1WTJ A;  4B6D A;  3TOA A;  3UGI A;  1CHO I;  1M8B A;  4E1P A;  3TJQ A;  1P9G A;  2A20 A;  5HQ8 A;  1MT1 A;  3TOB A;  3D00 A;  2DKV A;  1N13 A;  2ROW A;  2CWH A;  2NU4 I;  3FC3 A;  3TO6 A;  2V1C A;  1KBF A;  5CCL A;  2SGP I;  4L9M A;  1TGS I; 
#chains in the Genus database with same CATH homology
 2L8E A;  3OL0 A;  2B0U C;  1KBE A;  1PTR A;  2V1C C;  2ENN A;  4JCV E;  2SGQ I;  2N1A B;  2M5X A;  2N71 A;  4FKD A;  2OD1 A;  4UXI A;  1SGR I;  1XX6 A;  5FUY A;  2B8T A;  3PDN A;  1YU6 C;  1NUB A;  1VDD A;  1X4S A;  1AN1 I;  2V53 A;  3E2I A;  1SGY I;  2ORW A;  2E5R A;  3UEJ A;  3UGL A;  1CT4 I;  2QQD A;  2QQE A;  2SGF I;  1YTP A;  1DS3 I;  4OVO A;  1SGP I;  1BMO A;  2QPO A;  1PPF I;  2LUY A;  1LR7 A;  1OMT A;  2WCY A;  1LR8 A;  1PJU A;  2ORV A;  1IY5 A;  1TGS I;  4UXH A;  1XBT A;  1SGQ I;  1IY6 A;  2F3C I;  2W0T A;  3CXL A;  3UFF A;  1XA6 A;  1CGJ I;  1OMU A;  1V1H A;  1TUR A;  2XRC A;  2LEO A;  2JXD A;  5HI7 A;  3QTL D;  1FAR A;  3UEY A;  1Y1B A;  1SGE I;  1HPT A;  2SGD I;  2ELI A;  3OVO A;  3VE5 A;  2GVI A;  1OVO A;  1CSO I;  2SGE I;  1UVF A;  1CE3 A;  2L7X A;  1R0R I;  3B4V C;  1W4R A;  1KMA A;  1DS2 I;  1OYV I;  4SGB I;  1HJA I;  2QQ0 A;  5CCM A;  2JYY A;  5EX3 A;  1SGD I;  3OXF A;  1H0Z A;  3HH2 C;  1LR9 A;  2KCX A;  1FYB A;  5DAE A;  2KMO A;  4UXJ A;  2CJS C;  2DIP A;  1RFH A;  3E59 A;  3OXL A;  2GKR I;  2NU2 I;  1HDL A;  1TBO A;  2ENZ A;  5EX0 A;  2JA1 A;  2FNF X;  2UZ3 A;  2E73 A;  1X74 A;  2YUU A;  3VDP A;  2GKV A;  3OXG A;  4A24 A;  1PTQ A;  1FAQ A;  1IW4 A;  2N17 A;  1M8C A;  1TIH A;  1TUS A;  1CT2 I;  2GKT I;  4E1R A;  4HGU A;  1U5K A;  2J9R A;  2P6A C;  1UUC A;  1CT0 I;  2KMQ A;  4GI3 C;  2OVO A;  2KMR A;  3BJI A;  3VDU A;  2JZM A;  1BUS A;  2VRW B;  1PCE A;  2N52 A;  1TOT A;  2NU0 I;  3SEK C;  2ODD A;  1Y8F A;  3RU0 A;  1TBQ R;  1V1I A;  3UGD A;  1Y1C A;  1UVG A;  2J87 A;  2NU1 I;  1SGN I;  2K9H A;  2KMP A;  5FUV A;  5JHW C;  1TBR R;  1Z7K B;  3SGQ I;  2QQC A;  3GOX A;  2WVJ A;  3SGB I;  2ERW A;  5FUW A;  5FUX A;  1CGI I;  1R79 A;  2JW6 A;  2NU3 I;  2DB6 A;  3KY9 A;  3MEK A;  3QWP A;  2ARP F;  1W3S A;  1TBN A;  2YQP A;  4B6D A;  3UGI A;  1CHO I;  1M8B A;  4E1P A;  3TJQ A;  2A20 A;  5HQ8 A;  1MT1 A;  3D00 A;  1N13 A;  2ROW A;  2NU4 I;  3FC3 A;  2V1C A;  1KBF A;  5CCL A;  2SGP I;  4L9M A;  2BUS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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