1LR7A

Crystal structure of fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue sucrose octasulphate (sos)
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
73
structure length
73
Chain Sequence
ETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGKCK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
pubmed doi rcsb
molecule tags Hormone/growth factor
source organism Rattus norvegicus
molecule keywords follistatin
total genus 13
structure length 73
sequence length 73
ec nomenclature
pdb deposition date 2002-05-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07648 Kazal_2 Kazal-type serine protease inhibitor domain
A PF09289 FOLN Follistatin/Osteonectin-like EGF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 1lr7A00
1H0ZA 3QTLD 2KMOA 1Y1CA 2KMPA 2OVOA 1PPFI 1SGPI 3SGBI 1LR8A 2SGFI 1IW4A 2JZMA 2KCXA 1BUSA 1CE3A 1TBQR 1SGEI 1OMTA 1PJUA 2NU1I 2SGPI 2SGEI 1R0RI 1TBRR 2XRCA 1FYBA 2N17A 2GKVA 2NU4I 2ERWA 1AN1I 1UVGA 2NU3I 3OVOA 1CGJI 1TGSI 2KMQA 1CHOI 1TURA 1NUBA 2SGQI 1CT0I 3TJQA 1BMOA 1LR9A 2F3CI 4OVOA 1IY5A 1HJAI 1Y1BA 1LR7A 3B4VC 1HDLA 1SGNI 1IY6A 4SGBI 3SGQI 2V53A 1CGII 2WCYA 1YU6C 2M5XA 2JXDA 1UUCA 4GI3C 1TUSA 1DS3I 2N52A 2P6AC 2SGDI 3HH2C 3SEKC 2GKRI 5JHWC 2QQDA 1UVFA 2QQCA 1OMUA 1SGRI 1N13A 2KMRA 1YTPA 1M8CA 1SGDI 2ARPF 1CT4I 1DS2I 1HPTA 1M8BA 1OYVI 2B0UC 1PCEA 2NU2I 2BUSA 4HGUA 1SGQI 1Z7KB 1MT1A 2JYYA 1SGYI 2NU0I 2N71A 2GKTI 1CT2I 5DAEA 2LEOA 1CSOI 1OVOA 1TIHA 1KMAA
chains in the Genus database with same CATH superfamily
1H0ZA 2ORVA 1V1IA 2E5RA 2CWFA 1XA6A 3QTLD 2YUUA 3FSXA 1K7TA 1Z2IA 2KMOA 2RC4A 2UZ3A 1Y1CA 2CJSC 5FUXA 1KBFA 2ELIA 2KMPA 3QAHA 2OVOA 1PPFI 1TBNA 1K7VA 1SGPI 1WTJA 3SGBI 5FUWA 1LR8A 2OZUA 2SGFI 2CWGA 5HI7A 3RU0A 1IW4A 1WGTA 1Q9BA 2JZMA 2K9HA 2KCXA 2LB7A 9WGAA 2CWHA 2V1CC 4UXIA 1S20A 2WVJA 1FY7A 1WKXA 1W3SA 2ROWA 3E2IA 5E3RA 4E1PA 1BUSA 2YQPA 1CE3A 3OXLA 1TBQR 1UHAA 1SGEI 1OMTA 5EX0A 3UGDA 1WGCA 2OU2A 2RIJA 2GIVA 4FKDA 3VDUA 3OXFA 1PJUA 2NU1I 5E3PA 4L9MA 3GOXA 2SGPI 2QQEA 2ORWA 2SGEI 1R0RI 2ENZA 1TBRR 2XRCA 3CXLA 2N17A 5CCMA 2GKVA 2NU4I 3KY9A 3R5AA 7WGAA 2ERWA 1AN1I 1UVGA 2VRWB 5FUVA 5FUYA 2PQ8A 2NU3I 2WGCA 2FNFX 3OVOA 1CGJI 1TGSI 2KMQA 5E3QA 2A20A 2E73A 1PTRA 1CHOI 1FARA 1TURA 1NUBA 4UXHA 2SGQI 1HEVA 2DIPA 1CT0I 1ULKA 3TO7A 3TJQA 1BMOA 1R79A 1LR9A 2F3CI 3BJIA 3OXGA 1V1HA 3R5DA 3MEKA 3TO6A 4OVOA 2GVIA 3VDPA 1IY5A 1HJAI 1Y1BA 1ULMA 3PDNA 5HQ8A 1LR7A 3B4VC 4B6DA 1HDLA 1SGNI 1IY6A 1W4RA 2JW6A 4SGBI 2Y0MA 3UGLA 1P9ZA 2X3TA 3SGQI 2V53A 1CGII 2LUYA 2WCYA 1YU6C 5EX3A 2M5XA 3E59A 2JXDA 1UUCA 2JA1A 1XBTA 2N1AB 4GI3C 3UOEA 2J9RA 4JCVE 1RFHA 1TUSA 1DS3I 4A24A 1KBEA 2B8TA 1MJAA 2DKVA 2N52A 3UFFA 2P6AC 2SGDI 1X74A 3D00A 3HH2C 2GKRI 3SEKC 4AMLA 5J8CA 2UVOA 3QWPA 3VE5A 3UEJA 5JHWC 2QQDA 1U5KA 1UVFA 2QQCA 1OMUA 1SGRI 1N13A 1TOTA 2KMRA 1MJBA 1YTPA 2W0TA 1M8CA 4UXJA 1SGDI 2ARPF 4MPIA 2OD1A 1FAQA 5J8FA 4E1RA 2L7XA 1CT4I 1DS2I 1HPTA 1M8BA 1OYVI 1TBOA 3TO9A 1PTQA 2B0UC 5CCLA 1PCEA 1FYBA 2NU2I 1ULNA 1Y8FA 2BUSA 1X4SA 4HGUA 2ENNA 3TOAA 4WP4A 4DNCA 1SGQI 2QQ0A 1VDDA 1Z7KB 1MT1A 2JYYA 1SGYI 2X52A 3R5BA 3FC3A 3OL0A 2NU0I 2N71A 2V1CA 3R5CA 3UGIA 1P9GA 2QPOA 3TOBA 1MJ9A 2GKTI 3FSYA 2ODDA 1NXUA 1CT2I 1XX6A 1K7UA 5DAEA 2LEOA 2J87A 2DB6A 1CSOI 2L8EA 1OVOA 3UEYA 1TIHA 1KMAA
chains in the Genus database with same CATH topology
1H0ZA 2ORVA 1V1IA 2E5RA 1XA6A 3QTLD 2YUUA 2KMOA 2UZ3A 5FUXA 1Y1CA 2CJSC 1KBFA 2ELIA 2KMPA 2OVOA 1PPFI 1TBNA 1SGPI 3SGBI 5FUWA 1LR8A 2SGFI 3RU0A 5HI7A 1IW4A 2JZMA 2K9HA 2KCXA 2V1CC 4UXIA 2WVJA 2ROWA 3E2IA 1W3SA 4E1PA 1BUSA 2YQPA 1CE3A 3OXLA 1TBQR 5EX0A 1SGEI 1OMTA 3UGDA 4FKDA 3VDUA 3OXFA 1PJUA 2NU1I 4L9MA 3GOXA 2SGPI 2QQEA 2ORWA 2SGEI 1R0RI 2ENZA 1TBRR 2XRCA 3CXLA 2N17A 5CCMA 2GKVA 2NU4I 3KY9A 1FYBA 2ERWA 1AN1I 1UVGA 2VRWB 5FUVA 5FUYA 2NU3I 2FNFX 3OVOA 1CGJI 1TGSI 2KMQA 2A20A 2E73A 1PTRA 1CHOI 1FARA 1TURA 1NUBA 4UXHA 2SGQI 2DIPA 1CT0I 3TJQA 1BMOA 1R79A 1LR9A 2F3CI 3BJIA 3OXGA 1V1HA 3MEKA 4OVOA 2GVIA 3VDPA 1IY5A 1HJAI 1Y1BA 3PDNA 5HQ8A 1LR7A 3B4VC 4B6DA 1HDLA 1SGNI 1IY6A 1W4RA 2JW6A 4SGBI 3UGLA 3SGQI 2V53A 1CGII 2LUYA 2WCYA 1YU6C 5EX3A 2M5XA 3E59A 2JXDA 1UUCA 2JA1A 1XBTA 2N1AB 4GI3C 2J9RA 4JCVE 1RFHA 1TUSA 1DS3I 4A24A 1KBEA 2B8TA 2N52A 3UFFA 2P6AC 2SGDI 1X74A 3D00A 3HH2C 2GKRI 3SEKC 3QWPA 3VE5A 3UEJA 5JHWC 2QQDA 1U5KA 1UVFA 2QQCA 1OMUA 1SGRI 1N13A 1TOTA 2KMRA 1YTPA 2W0TA 1M8CA 4UXJA 1SGDI 2ARPF 2OD1A 1FAQA 4E1RA 2L7XA 1CT4I 1DS2I 1HPTA 1M8BA 1OYVI 1TBOA 1PTQA 2B0UC 5CCLA 1PCEA 2NU2I 1Y8FA 2BUSA 1X4SA 4HGUA 2ENNA 1SGQI 2QQ0A 1VDDA 1Z7KB 1MT1A 2JYYA 1SGYI 3FC3A 3OL0A 2NU0I 2N71A 2V1CA 3UGIA 2QPOA 2GKTI 2ODDA 1CT2I 1XX6A 5DAEA 2LEOA 2J87A 2DB6A 1CSOI 2L8EA 1OVOA 3UEYA 1TIHA 1KMAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1H0Z A;  3QTL D;  2KMO A;  1Y1C A;  2KMP A;  2OVO A;  1PPF I;  1SGP I;  3SGB I;  1LR8 A;  2SGF I;  1IW4 A;  2JZM A;  2KCX A;  1BUS A;  1CE3 A;  1TBQ R;  1SGE I;  1OMT A;  1PJU A;  2NU1 I;  2SGP I;  2SGE I;  1R0R I;  1TBR R;  2XRC A;  1FYB A;  2N17 A;  2GKV A;  2NU4 I;  2ERW A;  1AN1 I;  1UVG A;  2NU3 I;  3OVO A;  1CGJ I;  1TGS I;  2KMQ A;  1CHO I;  1TUR A;  1NUB A;  2SGQ I;  1CT0 I;  3TJQ A;  1BMO A;  1LR9 A;  2F3C I;  4OVO A;  1IY5 A;  1HJA I;  1Y1B A;  1LR7 A;  3B4V C;  1HDL A;  1SGN I;  1IY6 A;  4SGB I;  3SGQ I;  2V53 A;  1CGI I;  2WCY A;  1YU6 C;  2M5X A;  2JXD A;  1UUC A;  4GI3 C;  1TUS A;  1DS3 I;  2N52 A;  2P6A C;  2SGD I;  3HH2 C;  3SEK C;  2GKR I;  5JHW C;  2QQD A;  1UVF A;  2QQC A;  1OMU A;  1SGR I;  1N13 A;  2KMR A;  1YTP A;  1M8C A;  1SGD I;  2ARP F;  1CT4 I;  1DS2 I;  1HPT A;  1M8B A;  1OYV I;  2B0U C;  1PCE A;  2NU2 I;  2BUS A;  4HGU A;  1SGQ I;  1Z7K B;  1MT1 A;  2JYY A;  1SGY I;  2NU0 I;  2N71 A;  2GKT I;  1CT2 I;  5DAE A;  2LEO A;  1CSO I;  1OVO A;  1TIH A;  1KMA A; 
#chains in the Genus database with same CATH topology
 1H0Z A;  2ORV A;  1V1I A;  2E5R A;  2CWF A;  1XA6 A;  3QTL D;  2YUU A;  3FSX A;  1K7T A;  1Z2I A;  2KMO A;  2RC4 A;  2UZ3 A;  1Y1C A;  2CJS C;  5FUX A;  1KBF A;  2ELI A;  2KMP A;  3QAH A;  2OVO A;  1PPF I;  1TBN A;  1K7V A;  1SGP I;  1WTJ A;  3SGB I;  5FUW A;  1LR8 A;  2OZU A;  2SGF I;  2CWG A;  5HI7 A;  3RU0 A;  1IW4 A;  1WGT A;  1Q9B A;  2JZM A;  2K9H A;  2KCX A;  2LB7 A;  9WGA A;  2CWH A;  2V1C C;  4UXI A;  1S20 A;  2WVJ A;  1FY7 A;  1WKX A;  1W3S A;  2ROW A;  3E2I A;  5E3R A;  4E1P A;  1BUS A;  2YQP A;  1CE3 A;  3OXL A;  1TBQ R;  1UHA A;  1SGE I;  1OMT A;  5EX0 A;  3UGD A;  1WGC A;  2OU2 A;  2RIJ A;  2GIV A;  4FKD A;  3VDU A;  3OXF A;  1PJU A;  2NU1 I;  5E3P A;  4L9M A;  3GOX A;  2SGP I;  2QQE A;  2ORW A;  2SGE I;  1R0R I;  2ENZ A;  1TBR R;  2XRC A;  3CXL A;  2N17 A;  5CCM A;  2GKV A;  2NU4 I;  3KY9 A;  3R5A A;  7WGA A;  2ERW A;  1AN1 I;  1UVG A;  2VRW B;  5FUV A;  5FUY A;  2PQ8 A;  2NU3 I;  2WGC A;  2FNF X;  3OVO A;  1CGJ I;  1TGS I;  2KMQ A;  5E3Q A;  2A20 A;  2E73 A;  1PTR A;  1CHO I;  1FAR A;  1TUR A;  1NUB A;  4UXH A;  2SGQ I;  1HEV A;  2DIP A;  1CT0 I;  1ULK A;  3TO7 A;  3TJQ A;  1BMO A;  1R79 A;  1LR9 A;  2F3C I;  3BJI A;  3OXG A;  1V1H A;  3R5D A;  3MEK A;  3TO6 A;  4OVO A;  2GVI A;  3VDP A;  1IY5 A;  1HJA I;  1Y1B A;  1ULM A;  3PDN A;  5HQ8 A;  1LR7 A;  3B4V C;  4B6D A;  1HDL A;  1SGN I;  1IY6 A;  1W4R A;  2JW6 A;  4SGB I;  2Y0M A;  3UGL A;  1P9Z A;  2X3T A;  3SGQ I;  2V53 A;  1CGI I;  2LUY A;  2WCY A;  1YU6 C;  5EX3 A;  2M5X A;  3E59 A;  2JXD A;  1UUC A;  2JA1 A;  1XBT A;  2N1A B;  4GI3 C;  3UOE A;  2J9R A;  4JCV E;  1RFH A;  1TUS A;  1DS3 I;  4A24 A;  1KBE A;  2B8T A;  1MJA A;  2DKV A;  2N52 A;  3UFF A;  2P6A C;  2SGD I;  1X74 A;  3D00 A;  3HH2 C;  2GKR I;  3SEK C;  4AML A;  5J8C A;  2UVO A;  3QWP A;  3VE5 A;  3UEJ A;  5JHW C;  2QQD A;  1U5K A;  1UVF A;  2QQC A;  1OMU A;  1SGR I;  1N13 A;  1TOT A;  2KMR A;  1MJB A;  1YTP A;  2W0T A;  1M8C A;  4UXJ A;  1SGD I;  2ARP F;  4MPI A;  2OD1 A;  1FAQ A;  5J8F A;  4E1R A;  2L7X A;  1CT4 I;  1DS2 I;  1HPT A;  1M8B A;  1OYV I;  1TBO A;  3TO9 A;  1PTQ A;  2B0U C;  5CCL A;  1PCE A;  1FYB A;  2NU2 I;  1ULN A;  1Y8F A;  2BUS A;  1X4S A;  4HGU A;  2ENN A;  3TOA A;  4WP4 A;  4DNC A;  1SGQ I;  2QQ0 A;  1VDD A;  1Z7K B;  1MT1 A;  2JYY A;  1SGY I;  2X52 A;  3R5B A;  3FC3 A;  3OL0 A;  2NU0 I;  2N71 A;  2V1C A;  3R5C A;  3UGI A;  1P9G A;  2QPO A;  3TOB A;  1MJ9 A;  2GKT I;  3FSY A;  2ODD A;  1NXU A;  1CT2 I;  1XX6 A;  1K7U A;  5DAE A;  2LEO A;  2J87 A;  2DB6 A;  1CSO I;  2L8E A;  1OVO A;  3UEY A;  1TIH A;  1KMA A; 
#chains in the Genus database with same CATH homology
 1H0Z A;  2ORV A;  1V1I A;  2E5R A;  1XA6 A;  3QTL D;  2YUU A;  2KMO A;  2UZ3 A;  5FUX A;  1Y1C A;  2CJS C;  1KBF A;  2ELI A;  2KMP A;  2OVO A;  1PPF I;  1TBN A;  1SGP I;  3SGB I;  5FUW A;  1LR8 A;  2SGF I;  3RU0 A;  5HI7 A;  1IW4 A;  2JZM A;  2K9H A;  2KCX A;  2V1C C;  4UXI A;  2WVJ A;  2ROW A;  3E2I A;  1W3S A;  4E1P A;  1BUS A;  2YQP A;  1CE3 A;  3OXL A;  1TBQ R;  5EX0 A;  1SGE I;  1OMT A;  3UGD A;  4FKD A;  3VDU A;  3OXF A;  1PJU A;  2NU1 I;  4L9M A;  3GOX A;  2SGP I;  2QQE A;  2ORW A;  2SGE I;  1R0R I;  2ENZ A;  1TBR R;  2XRC A;  3CXL A;  2N17 A;  5CCM A;  2GKV A;  2NU4 I;  3KY9 A;  1FYB A;  2ERW A;  1AN1 I;  1UVG A;  2VRW B;  5FUV A;  5FUY A;  2NU3 I;  2FNF X;  3OVO A;  1CGJ I;  1TGS I;  2KMQ A;  2A20 A;  2E73 A;  1PTR A;  1CHO I;  1FAR A;  1TUR A;  1NUB A;  4UXH A;  2SGQ I;  2DIP A;  1CT0 I;  3TJQ A;  1BMO A;  1R79 A;  1LR9 A;  2F3C I;  3BJI A;  3OXG A;  1V1H A;  3MEK A;  4OVO A;  2GVI A;  3VDP A;  1IY5 A;  1HJA I;  1Y1B A;  3PDN A;  5HQ8 A;  1LR7 A;  3B4V C;  4B6D A;  1HDL A;  1SGN I;  1IY6 A;  1W4R A;  2JW6 A;  4SGB I;  3UGL A;  3SGQ I;  2V53 A;  1CGI I;  2LUY A;  2WCY A;  1YU6 C;  5EX3 A;  2M5X A;  3E59 A;  2JXD A;  1UUC A;  2JA1 A;  1XBT A;  2N1A B;  4GI3 C;  2J9R A;  4JCV E;  1RFH A;  1TUS A;  1DS3 I;  4A24 A;  1KBE A;  2B8T A;  2N52 A;  3UFF A;  2P6A C;  2SGD I;  1X74 A;  3D00 A;  3HH2 C;  2GKR I;  3SEK C;  3QWP A;  3VE5 A;  3UEJ A;  5JHW C;  2QQD A;  1U5K A;  1UVF A;  2QQC A;  1OMU A;  1SGR I;  1N13 A;  1TOT A;  2KMR A;  1YTP A;  2W0T A;  1M8C A;  4UXJ A;  1SGD I;  2ARP F;  2OD1 A;  1FAQ A;  4E1R A;  2L7X A;  1CT4 I;  1DS2 I;  1HPT A;  1M8B A;  1OYV I;  1TBO A;  1PTQ A;  2B0U C;  5CCL A;  1PCE A;  2NU2 I;  1Y8F A;  2BUS A;  1X4S A;  4HGU A;  2ENN A;  1SGQ I;  2QQ0 A;  1VDD A;  1Z7K B;  1MT1 A;  2JYY A;  1SGY I;  3FC3 A;  3OL0 A;  2NU0 I;  2N71 A;  2V1C A;  3UGI A;  2QPO A;  2GKT I;  2ODD A;  1CT2 I;  1XX6 A;  5DAE A;  2LEO A;  2J87 A;  2DB6 A;  1CSO I;  2L8E A;  1OVO A;  3UEY A;  1TIH A;  1KMA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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