1LR9A

Structure of fs1, the heparin-binding domain of follistatin
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
73
structure length
73
Chain Sequence
ETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGKCK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
pubmed doi rcsb
molecule tags Hormone/growth factor
source organism Rattus norvegicus
molecule keywords Follistatin
total genus 11
structure length 73
sequence length 73
ec nomenclature
pdb deposition date 2002-05-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07648 Kazal_2 Kazal-type serine protease inhibitor domain
A PF09289 FOLN Follistatin/Osteonectin-like EGF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 1lr9A00
1SGYI 1HJAI 1Y1BA 2KMOA 1CHOI 2KMPA 2B0UC 1H0ZA 1LR7A 1OMUA 1NUBA 3B4VC 1SGNI 1HDLA 1R0RI 2KCXA 2QQCA 1OMTA 1UUCA 1Z7KB 1OVOA 1N13A 2GKRI 1TBRR 1TBQR 1IW4A 2WCYA 1YU6C 3HH2C 5JHWC 1DS2I 1AN1I 1LR8A 2XRCA 1M8BA 1PPFI 1SGRI 2NU4I 2JZMA 1TUSA 2SGQI 1TURA 2JXDA 1PJUA 3SEKC 1BUSA 5DAEA 1LR9A 2P6AC 2KMRA 4GI3C 1TGSI 1CGII 1SGQI 2NU0I 1SGDI 1KMAA 1UVFA 4SGBI 3QTLD 1CSOI 1CT0I 2GKTI 2NU2I 2SGDI 1IY6A 2KMQA 3SGBI 4HGUA 2N52A 1Y1CA 1BMOA 1OYVI 2N71A 2ARPF 1PCEA 1CGJI 1CT4I 2ERWA 1MT1A 2SGFI 2NU1I 2GKVA 1SGPI 1HPTA 1YTPA 2BUSA 2F3CI 1CT2I 2OVOA 1UVGA 1IY5A 3OVOA 2N17A 2QQDA 2JYYA 1DS3I 1SGEI 1CE3A 1FYBA 2V53A 1M8CA 1TIHA 3SGQI 2LEOA 2NU3I 2SGEI 3TJQA 2M5XA 2SGPI 4OVOA
chains in the Genus database with same CATH superfamily
1SGYI 1V1HA 1HJAI 1Y1BA 2KMOA 1P9GA 3FSYA 2Y0MA 1CHOI 2KMPA 3D00A 4E1RA 2B0UC 2E73A 3UOEA 1Z2IA 1LR7A 1H0ZA 5CCMA 3TOAA 1KBFA 3E59A 5E3PA 2L7XA 2OD1A 1OMUA 2J87A 2N1AB 2RIJA 1NUBA 3OL0A 2B8TA 3B4VC 1ULKA 3PDNA 3TO9A 3UGIA 7WGAA 1WGCA 2JA1A 1SGNI 1HDLA 5J8CA 1R0RI 2KCXA 5EX0A 2DB6A 2QQCA 3UEYA 3VE5A 1OMTA 1UUCA 1Z7KB 1OVOA 1N13A 2A20A 4B6DA 2GKRI 2QQ0A 1TBRR 1TBQR 4FKDA 2WCYA 4UXJA 1RFHA 1YU6C 1FARA 3QAHA 3HH2C 5JHWC 1IW4A 1NXUA 2JW6A 1DS2I 1AN1I 1LR8A 4UXIA 2XRCA 2QPOA 1M8BA 1PPFI 1SGRI 2WVJA 2NU4I 2QQEA 1Y8FA 2JZMA 1TUSA 2SGQI 2ODDA 1TURA 4E1PA 2JXDA 1PJUA 3SEKC 4L9MA 3VDPA 3TO7A 1BUSA 5DAEA 1K7UA 1MJBA 1LR9A 2P6AC 3E2IA 2KMRA 3FSXA 4GI3C 2ORWA 5J8FA 1TGSI 2X3TA 1CGII 1SGQI 2NU0I 1TBNA 1MJ9A 1SGDI 1V1IA 2CWGA 1KMAA 5FUYA 1Q9BA 1X74A 1UVFA 2J9RA 1TBOA 3QTLD 4SGBI 1CSOI 1TOTA 4A24A 1CT0I 2GKTI 1FY7A 1WKXA 3BJIA 2NU2I 1K7TA 2SGDI 5FUWA 3R5DA 1P9ZA 1IY6A 2LUYA 2KMQA 2ELIA 2DIPA 2V1CC 4HGUA 3SGBI 1PTRA 1WTJA 1MJAA 2W0TA 2N52A 1Y1CA 3GOXA 1XA6A 3MEKA 9WGAA 1BMOA 2OU2A 3FC3A 2RC4A 1OYVI 1X4SA 2X52A 2N71A 2ARPF 3OXGA 1PCEA 1CGJI 1CT4I 1U5KA 2E5RA 2ERWA 4WP4A 1MT1A 1FAQA 2SGFI 2NU1I 3UGDA 5HI7A 3RU0A 2ROWA 3R5AA 4AMLA 3UGLA 1S20A 1SGPI 2GKVA 3VDUA 3R5BA 2LB7A 1HPTA 2L8EA 1YTPA 3UEJA 2FNFX 1W4RA 2UVOA 2BUSA 2ORVA 2F3CI 3CXLA 1CT2I 4MPIA 1ULNA 2OVOA 2OZUA 2YUUA 1UVGA 2ENZA 2GIVA 3KY9A 5HQ8A 2ENNA 4UXHA 3TO6A 2DKVA 1K7VA 1ULMA 3UFFA 3OVOA 1IY5A 2UZ3A 2N17A 2YQPA 2PQ8A 3OXFA 2CWFA 2QQDA 2CJSC 2WGCA 1W3SA 4JCVE 1XX6A 2JYYA 3QWPA 1DS3I 2K9HA 5E3RA 1SGEI 3TOBA 1XBTA 1WGTA 3OXLA 5FUVA 1CE3A 1KBEA 1FYBA 2V53A 2V1CA 3R5CA 1UHAA 1VDDA 1M8CA 1PTQA 2GVIA 1R79A 5E3QA 1TIHA 5FUXA 3SGQI 2LEOA 4DNCA 2NU3I 2CWHA 2SGEI 5CCLA 2VRWB 3TJQA 1HEVA 2M5XA 5EX3A 2SGPI 4OVOA
chains in the Genus database with same CATH topology
1SGYI 1V1HA 1HJAI 1Y1BA 2KMOA 1CHOI 2KMPA 3D00A 4E1RA 2B0UC 2E73A 1H0ZA 1LR7A 5CCMA 1KBFA 3E59A 2L7XA 2OD1A 1OMUA 2J87A 2N1AB 1NUBA 3OL0A 2B8TA 3B4VC 3PDNA 3UGIA 2JA1A 1SGNI 1HDLA 1R0RI 2KCXA 5EX0A 2DB6A 2QQCA 3UEYA 3VE5A 1OMTA 1UUCA 1Z7KB 1OVOA 1N13A 2A20A 4B6DA 2GKRI 2QQ0A 1TBRR 1TBQR 4FKDA 2WCYA 4UXJA 1RFHA 1YU6C 1FARA 1IW4A 3HH2C 5JHWC 2JW6A 1DS2I 1AN1I 1LR8A 4UXIA 2XRCA 2QPOA 1M8BA 1PPFI 1SGRI 2WVJA 2NU4I 2QQEA 1Y8FA 2JZMA 1TUSA 2SGQI 2ODDA 1TURA 4E1PA 2JXDA 1PJUA 3SEKC 4L9MA 3VDPA 1BUSA 5DAEA 3E2IA 1LR9A 2P6AC 2KMRA 4GI3C 2ORWA 1TGSI 1CGII 1SGQI 2NU0I 1TBNA 1SGDI 1V1IA 1KMAA 5FUYA 1X74A 1UVFA 2J9RA 1TBOA 3QTLD 4SGBI 1CSOI 1TOTA 4A24A 1CT0I 2GKTI 3BJIA 2NU2I 2SGDI 5FUWA 1IY6A 2LUYA 2KMQA 2ELIA 2DIPA 2V1CC 4HGUA 3SGBI 1PTRA 2W0TA 2N52A 1Y1CA 3GOXA 1XA6A 3MEKA 1BMOA 3FC3A 1OYVI 1X4SA 2N71A 2ARPF 3OXGA 1PCEA 1CGJI 1CT4I 1U5KA 2E5RA 2ERWA 1FAQA 1MT1A 2SGFI 2NU1I 3UGDA 5HI7A 3RU0A 2ROWA 3UGLA 2GKVA 1SGPI 3VDUA 1HPTA 2L8EA 1YTPA 3UEJA 2FNFX 1W4RA 2BUSA 2ORVA 2F3CI 3CXLA 1CT2I 2OVOA 2YUUA 1UVGA 2ENZA 3KY9A 5HQ8A 2ENNA 4UXHA 3UFFA 3OVOA 1IY5A 2UZ3A 2N17A 2YQPA 3OXFA 2QQDA 2CJSC 1W3SA 4JCVE 1XX6A 2JYYA 3QWPA 1DS3I 2K9HA 1SGEI 1XBTA 3OXLA 5FUVA 1CE3A 1KBEA 1FYBA 2V53A 2V1CA 1VDDA 1M8CA 1PTQA 2GVIA 1R79A 5FUXA 1TIHA 3SGQI 2LEOA 2NU3I 2SGEI 5CCLA 2VRWB 3TJQA 2M5XA 5EX3A 2SGPI 4OVOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SGY I;  1HJA I;  1Y1B A;  2KMO A;  1CHO I;  2KMP A;  2B0U C;  1H0Z A;  1LR7 A;  1OMU A;  1NUB A;  3B4V C;  1SGN I;  1HDL A;  1R0R I;  2KCX A;  2QQC A;  1OMT A;  1UUC A;  1Z7K B;  1OVO A;  1N13 A;  2GKR I;  1TBR R;  1TBQ R;  1IW4 A;  2WCY A;  1YU6 C;  3HH2 C;  5JHW C;  1DS2 I;  1AN1 I;  1LR8 A;  2XRC A;  1M8B A;  1PPF I;  1SGR I;  2NU4 I;  2JZM A;  1TUS A;  2SGQ I;  1TUR A;  2JXD A;  1PJU A;  3SEK C;  1BUS A;  5DAE A;  1LR9 A;  2P6A C;  2KMR A;  4GI3 C;  1TGS I;  1CGI I;  1SGQ I;  2NU0 I;  1SGD I;  1KMA A;  1UVF A;  4SGB I;  3QTL D;  1CSO I;  1CT0 I;  2GKT I;  2NU2 I;  2SGD I;  1IY6 A;  2KMQ A;  3SGB I;  4HGU A;  2N52 A;  1Y1C A;  1BMO A;  1OYV I;  2N71 A;  2ARP F;  1PCE A;  1CGJ I;  1CT4 I;  2ERW A;  1MT1 A;  2SGF I;  2NU1 I;  2GKV A;  1SGP I;  1HPT A;  1YTP A;  2BUS A;  2F3C I;  1CT2 I;  2OVO A;  1UVG A;  1IY5 A;  3OVO A;  2N17 A;  2QQD A;  2JYY A;  1DS3 I;  1SGE I;  1CE3 A;  1FYB A;  2V53 A;  1M8C A;  1TIH A;  3SGQ I;  2LEO A;  2NU3 I;  2SGE I;  3TJQ A;  2M5X A;  2SGP I;  4OVO A; 
#chains in the Genus database with same CATH topology
 1SGY I;  1V1H A;  1HJA I;  1Y1B A;  2KMO A;  1P9G A;  3FSY A;  2Y0M A;  1CHO I;  2KMP A;  3D00 A;  4E1R A;  2B0U C;  2E73 A;  3UOE A;  1Z2I A;  1LR7 A;  1H0Z A;  5CCM A;  3TOA A;  1KBF A;  3E59 A;  5E3P A;  2L7X A;  2OD1 A;  1OMU A;  2J87 A;  2N1A B;  2RIJ A;  1NUB A;  3OL0 A;  2B8T A;  3B4V C;  1ULK A;  3PDN A;  3TO9 A;  3UGI A;  7WGA A;  1WGC A;  2JA1 A;  1SGN I;  1HDL A;  5J8C A;  1R0R I;  2KCX A;  5EX0 A;  2DB6 A;  2QQC A;  3UEY A;  3VE5 A;  1OMT A;  1UUC A;  1Z7K B;  1OVO A;  1N13 A;  2A20 A;  4B6D A;  2GKR I;  2QQ0 A;  1TBR R;  1TBQ R;  4FKD A;  2WCY A;  4UXJ A;  1RFH A;  1YU6 C;  1FAR A;  3QAH A;  3HH2 C;  5JHW C;  1IW4 A;  1NXU A;  2JW6 A;  1DS2 I;  1AN1 I;  1LR8 A;  4UXI A;  2XRC A;  2QPO A;  1M8B A;  1PPF I;  1SGR I;  2WVJ A;  2NU4 I;  2QQE A;  1Y8F A;  2JZM A;  1TUS A;  2SGQ I;  2ODD A;  1TUR A;  4E1P A;  2JXD A;  1PJU A;  3SEK C;  4L9M A;  3VDP A;  3TO7 A;  1BUS A;  5DAE A;  1K7U A;  1MJB A;  1LR9 A;  2P6A C;  3E2I A;  2KMR A;  3FSX A;  4GI3 C;  2ORW A;  5J8F A;  1TGS I;  2X3T A;  1CGI I;  1SGQ I;  2NU0 I;  1TBN A;  1MJ9 A;  1SGD I;  1V1I A;  2CWG A;  1KMA A;  5FUY A;  1Q9B A;  1X74 A;  1UVF A;  2J9R A;  1TBO A;  3QTL D;  4SGB I;  1CSO I;  1TOT A;  4A24 A;  1CT0 I;  2GKT I;  1FY7 A;  1WKX A;  3BJI A;  2NU2 I;  1K7T A;  2SGD I;  5FUW A;  3R5D A;  1P9Z A;  1IY6 A;  2LUY A;  2KMQ A;  2ELI A;  2DIP A;  2V1C C;  4HGU A;  3SGB I;  1PTR A;  1WTJ A;  1MJA A;  2W0T A;  2N52 A;  1Y1C A;  3GOX A;  1XA6 A;  3MEK A;  9WGA A;  1BMO A;  2OU2 A;  3FC3 A;  2RC4 A;  1OYV I;  1X4S A;  2X52 A;  2N71 A;  2ARP F;  3OXG A;  1PCE A;  1CGJ I;  1CT4 I;  1U5K A;  2E5R A;  2ERW A;  4WP4 A;  1MT1 A;  1FAQ A;  2SGF I;  2NU1 I;  3UGD A;  5HI7 A;  3RU0 A;  2ROW A;  3R5A A;  4AML A;  3UGL A;  1S20 A;  1SGP I;  2GKV A;  3VDU A;  3R5B A;  2LB7 A;  1HPT A;  2L8E A;  1YTP A;  3UEJ A;  2FNF X;  1W4R A;  2UVO A;  2BUS A;  2ORV A;  2F3C I;  3CXL A;  1CT2 I;  4MPI A;  1ULN A;  2OVO A;  2OZU A;  2YUU A;  1UVG A;  2ENZ A;  2GIV A;  3KY9 A;  5HQ8 A;  2ENN A;  4UXH A;  3TO6 A;  2DKV A;  1K7V A;  1ULM A;  3UFF A;  3OVO A;  1IY5 A;  2UZ3 A;  2N17 A;  2YQP A;  2PQ8 A;  3OXF A;  2CWF A;  2QQD A;  2CJS C;  2WGC A;  1W3S A;  4JCV E;  1XX6 A;  2JYY A;  3QWP A;  1DS3 I;  2K9H A;  5E3R A;  1SGE I;  3TOB A;  1XBT A;  1WGT A;  3OXL A;  5FUV A;  1CE3 A;  1KBE A;  1FYB A;  2V53 A;  2V1C A;  3R5C A;  1UHA A;  1VDD A;  1M8C A;  1PTQ A;  2GVI A;  1R79 A;  5E3Q A;  1TIH A;  5FUX A;  3SGQ I;  2LEO A;  4DNC A;  2NU3 I;  2CWH A;  2SGE I;  5CCL A;  2VRW B;  3TJQ A;  1HEV A;  2M5X A;  5EX3 A;  2SGP I;  4OVO A; 
#chains in the Genus database with same CATH homology
 1SGY I;  1V1H A;  1HJA I;  1Y1B A;  2KMO A;  1CHO I;  2KMP A;  3D00 A;  4E1R A;  2B0U C;  2E73 A;  1H0Z A;  1LR7 A;  5CCM A;  1KBF A;  3E59 A;  2L7X A;  2OD1 A;  1OMU A;  2J87 A;  2N1A B;  1NUB A;  3OL0 A;  2B8T A;  3B4V C;  3PDN A;  3UGI A;  2JA1 A;  1SGN I;  1HDL A;  1R0R I;  2KCX A;  5EX0 A;  2DB6 A;  2QQC A;  3UEY A;  3VE5 A;  1OMT A;  1UUC A;  1Z7K B;  1OVO A;  1N13 A;  2A20 A;  4B6D A;  2GKR I;  2QQ0 A;  1TBR R;  1TBQ R;  4FKD A;  2WCY A;  4UXJ A;  1RFH A;  1YU6 C;  1FAR A;  1IW4 A;  3HH2 C;  5JHW C;  2JW6 A;  1DS2 I;  1AN1 I;  1LR8 A;  4UXI A;  2XRC A;  2QPO A;  1M8B A;  1PPF I;  1SGR I;  2WVJ A;  2NU4 I;  2QQE A;  1Y8F A;  2JZM A;  1TUS A;  2SGQ I;  2ODD A;  1TUR A;  4E1P A;  2JXD A;  1PJU A;  3SEK C;  4L9M A;  3VDP A;  1BUS A;  5DAE A;  3E2I A;  1LR9 A;  2P6A C;  2KMR A;  4GI3 C;  2ORW A;  1TGS I;  1CGI I;  1SGQ I;  2NU0 I;  1TBN A;  1SGD I;  1V1I A;  1KMA A;  5FUY A;  1X74 A;  1UVF A;  2J9R A;  1TBO A;  3QTL D;  4SGB I;  1CSO I;  1TOT A;  4A24 A;  1CT0 I;  2GKT I;  3BJI A;  2NU2 I;  2SGD I;  5FUW A;  1IY6 A;  2LUY A;  2KMQ A;  2ELI A;  2DIP A;  2V1C C;  4HGU A;  3SGB I;  1PTR A;  2W0T A;  2N52 A;  1Y1C A;  3GOX A;  1XA6 A;  3MEK A;  1BMO A;  3FC3 A;  1OYV I;  1X4S A;  2N71 A;  2ARP F;  3OXG A;  1PCE A;  1CGJ I;  1CT4 I;  1U5K A;  2E5R A;  2ERW A;  1FAQ A;  1MT1 A;  2SGF I;  2NU1 I;  3UGD A;  5HI7 A;  3RU0 A;  2ROW A;  3UGL A;  2GKV A;  1SGP I;  3VDU A;  1HPT A;  2L8E A;  1YTP A;  3UEJ A;  2FNF X;  1W4R A;  2BUS A;  2ORV A;  2F3C I;  3CXL A;  1CT2 I;  2OVO A;  2YUU A;  1UVG A;  2ENZ A;  3KY9 A;  5HQ8 A;  2ENN A;  4UXH A;  3UFF A;  3OVO A;  1IY5 A;  2UZ3 A;  2N17 A;  2YQP A;  3OXF A;  2QQD A;  2CJS C;  1W3S A;  4JCV E;  1XX6 A;  2JYY A;  3QWP A;  1DS3 I;  2K9H A;  1SGE I;  1XBT A;  3OXL A;  5FUV A;  1CE3 A;  1KBE A;  1FYB A;  2V53 A;  2V1C A;  1VDD A;  1M8C A;  1PTQ A;  2GVI A;  1R79 A;  5FUX A;  1TIH A;  3SGQ I;  2LEO A;  2NU3 I;  2SGE I;  5CCL A;  2VRW B;  3TJQ A;  2M5X A;  5EX3 A;  2SGP I;  4OVO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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