1TBQR

Crystal structure of insect derived double domain kazal inhibitor rhodniin in complex with thrombin
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
103
structure length
103
Chain Sequence
EGGEPCACPHALHRVCGSDGETYSNPCTLNCAKFNGKPELVKVHDGPCEPDEDEDVCQECDGDEYKPVCGSDDITYDNNCRLECASISSSPGVELKHEGPCRT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin.
pubmed rcsb
molecule tags Complex (serine protease/inhibitor)
source organism Rhodnius prolixus
molecule keywords THROMBIN
total genus 24
structure length 103
sequence length 103
chains with identical sequence S
ec nomenclature
pdb deposition date 1995-03-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
R PF00050 Kazal_1 Kazal-type serine protease inhibitor domain
R PF07648 Kazal_2 Kazal-type serine protease inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 1tbqR02
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 1tbqR01
1TBQR 1SGQI 1LR7A 1CGII 2GKRI 2KCXA 2N71A 2GKTI 2NU1I 1DS3I 1Y1BA 2KMPA 1LR8A 1YU6C 1SGNI 1CSOI 1TIHA 2GKVA 2KMOA 1KMAA 1DS2I 2QQCA 2N17A 1Y1CA 1SGPI 3OVOA 1HJAI 4HGUA 1M8BA 2OVOA 1N13A 4OVOA 1OMTA 2NU2I 2KMRA 1HPTA 1CT0I 3QTLD 2NU0I 2SGPI 5JHWC 1SGRI 1FYBA 1YTPA 2SGQI 1UUCA 1IY6A 2JYYA 2JXDA 2SGDI 1UVFA 1PJUA 1TBRR 1AN1I 3HH2C 2N52A 2QQDA 1BMOA 1SGYI 1OMUA 1NUBA 1TURA 3SEKC 2XRCA 1OVOA 1H0ZA 3B4VC 3SGQI 1HDLA 1UVGA 2KMQA 1PPFI 2LEOA 2V53A 3SGBI 2SGEI 1Z7KB 1PCEA 2ARPF 1TUSA 4GI3C 5DAEA 1MT1A 1BUSA 1CGJI 2ERWA 2JZMA 1M8CA 1R0RI 2BUSA 2F3CI 2NU4I 1CT2I 1OYVI 1LR9A 1CHOI 1CT4I 1IY5A 1SGDI 2SGFI 4SGBI 2P6AC 2M5XA 3TJQA 1IW4A 1TGSI 1SGEI 2WCYA 2B0UC 2NU3I 1CE3A
chains in the Genus database with same CATH superfamily
1TBQR 1SGQI 5HQ8A 1KBEA 1LR7A 2OZUA 4FKDA 1CGII 4JCVE 2GKRI 1ULNA 2DB6A 2GVIA 2KCXA 2N71A 1FAQA 5E3PA 3TO7A 1Y8FA 2GKTI 2NU1I 5FUYA 1DS3I 2CJSC 2WGCA 1P9GA 2W0TA 3R5CA 3QWPA 1Y1BA 1NXUA 2L7XA 2KMPA 1LR8A 1YU6C 5CCMA 3VDUA 1SGNI 1CSOI 2LUYA 2DKVA 3VDPA 1TIHA 3CXLA 2GKVA 2B8TA 2ORWA 2QPOA 1MJBA 3UEJA 5J8CA 1VDDA 2ODDA 2KMOA 1S20A 2K9HA 2VRWB 5FUXA 1KMAA 1K7UA 1DS2I 3FSXA 5FUWA 1ULMA 2UVOA 2JW6A 2QQCA 1WGTA 3OXFA 5J8FA 2N17A 1Y1CA 3QAHA 3OL0A 4UXIA 1SGPI 3OVOA 1XX6A 2ROWA 9WGAA 3GOXA 1P9ZA 5E3QA 2LB7A 4WP4A 1U5KA 5HI7A 1HJAI 4HGUA 1M8BA 2ORVA 3UGIA 2OVOA 2V1CA 3UEYA 1N13A 4OVOA 4E1PA 5CCLA 3KY9A 2J87A 1OMTA 3OXGA 2NU2I 2KMRA 2PQ8A 2QQEA 1HPTA 1W4RA 2OU2A 1CT0I 4UXHA 2CWHA 3QTLD 2NU0I 2X3TA 5EX0A 2SGPI 5JHWC 4L9MA 1FY7A 1SGRI 2UZ3A 2DIPA 1FYBA 2V1CC 1YTPA 1TBNA 2SGQI 3MEKA 1UUCA 1IY6A 2ELIA 2JXDA 2JYYA 2SGDI 1UVFA 1PJUA 1TBRR 1WKXA 3FSYA 3VE5A 1AN1I 3HH2C 3R5DA 2N52A 4E1RA 2JA1A 2QQDA 2CWGA 4A24A 2ENNA 5E3RA 2ENZA 1BMOA 2A20A 2YQPA 1SGYI 2Y0MA 1OMUA 1NUBA 1TURA 2OD1A 3SEKC 1MJAA 2XRCA 1OVOA 1WTJA 1H0ZA 1PTRA 2E73A 3B4VC 3TO9A 3R5BA 3SGQI 1HDLA 5EX3A 3TOBA 5FUVA 1UVGA 2L8EA 2KMQA 1PPFI 4MPIA 2YUUA 1MJ9A 2LEOA 3E59A 2V53A 2WVJA 3SGBI 2SGEI 1Z7KB 1PCEA 1HEVA 2ARPF 2RIJA 1TUSA 3E2IA 3UGDA 2J9RA 1ULKA 3RU0A 1Q9BA 1V1HA 3PDNA 4GI3C 1PTQA 1TBOA 4DNCA 3UGLA 3TO6A 1Z2IA 2RC4A 5DAEA 1MT1A 3UFFA 1BUSA 1CGJI 2ERWA 2JZMA 1M8CA 1XBTA 3TOAA 7WGAA 1R0RI 3FC3A 2BUSA 1W3SA 2FNFX 1KBFA 2F3CI 2N1AB 1R79A 1K7VA 1WGCA 1V1IA 1CT2I 1OYVI 1LR9A 1CHOI 1CT4I 1TOTA 2NU4I 2QQ0A 1IY5A 2X52A 1UHAA 1SGDI 2GIVA 1RFHA 4UXJA 3D00A 2CWFA 4B6DA 2E5RA 2SGFI 4SGBI 4AMLA 2P6AC 3UOEA 2M5XA 3TJQA 1K7TA 1IW4A 1TGSI 1XA6A 3R5AA 1X74A 1SGEI 3OXLA 2WCYA 1X4SA 2B0UC 2NU3I 3BJIA 1FARA 1CE3A
chains in the Genus database with same CATH topology
1TBQR 1SGQI 5HQ8A 1KBEA 1LR7A 4FKDA 1CGII 4JCVE 2GKRI 2DB6A 2GVIA 2KCXA 2N71A 1FAQA 1Y8FA 2GKTI 2NU1I 5FUYA 1DS3I 2CJSC 2W0TA 3QWPA 1Y1BA 2L7XA 2KMPA 1LR8A 1YU6C 5CCMA 3VDUA 1SGNI 1CSOI 2LUYA 3VDPA 1TIHA 3CXLA 2GKVA 2B8TA 2ORWA 2QPOA 3UEJA 1VDDA 2ODDA 2KMOA 2VRWB 2K9HA 1KMAA 5FUXA 1DS2I 5FUWA 2JW6A 2QQCA 3OXFA 2N17A 1Y1CA 3OL0A 4UXIA 1SGPI 3OVOA 1XX6A 2ROWA 3GOXA 1U5KA 5HI7A 1HJAI 4HGUA 1M8BA 2ORVA 3UGIA 2OVOA 2V1CA 3UEYA 1N13A 4OVOA 4E1PA 5CCLA 3KY9A 2J87A 1OMTA 3OXGA 2NU2I 2KMRA 2QQEA 1HPTA 1W4RA 1CT0I 4UXHA 3QTLD 2NU0I 5EX0A 2SGPI 5JHWC 4L9MA 1SGRI 2UZ3A 2DIPA 1FYBA 2V1CC 1YTPA 1TBNA 2SGQI 3MEKA 1UUCA 1IY6A 2ELIA 2JXDA 2JYYA 2SGDI 1UVFA 1PJUA 1TBRR 3VE5A 1AN1I 3HH2C 4E1RA 2N52A 2JA1A 2QQDA 4A24A 2ENNA 2ENZA 1BMOA 2A20A 2YQPA 1SGYI 1OMUA 1NUBA 1TURA 2OD1A 3SEKC 2XRCA 1OVOA 1H0ZA 1PTRA 2E73A 3B4VC 3SGQI 1HDLA 5EX3A 5FUVA 1UVGA 2L8EA 2KMQA 1PPFI 2YUUA 2LEOA 3E59A 2V53A 2WVJA 3SGBI 2SGEI 1Z7KB 1PCEA 2ARPF 3E2IA 1TUSA 3UGDA 2J9RA 3RU0A 4GI3C 1V1HA 3PDNA 1PTQA 1TBOA 3UGLA 5DAEA 1MT1A 3UFFA 1BUSA 1CGJI 2ERWA 2JZMA 1M8CA 1XBTA 1R0RI 3FC3A 2BUSA 1W3SA 2FNFX 1KBFA 2F3CI 2N1AB 1R79A 2NU4I 1V1IA 1CT2I 1OYVI 1LR9A 1CHOI 1CT4I 1TOTA 2QQ0A 1IY5A 1SGDI 1RFHA 4UXJA 3D00A 4B6DA 2E5RA 2SGFI 4SGBI 2P6AC 2M5XA 3TJQA 1IW4A 1TGSI 1XA6A 1X74A 1SGEI 3OXLA 2WCYA 1X4SA 2B0UC 2NU3I 3BJIA 1FARA 1CE3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TBQ R;  1SGQ I;  1LR7 A;  1CGI I;  2GKR I;  2KCX A;  2N71 A;  2GKT I;  2NU1 I;  1DS3 I;  1Y1B A;  2KMP A;  1LR8 A;  1YU6 C;  1SGN I;  1CSO I;  1TIH A;  2GKV A;  2KMO A;  1KMA A;  1DS2 I;  2QQC A;  2N17 A;  1Y1C A;  1SGP I;  3OVO A;  1HJA I;  4HGU A;  1M8B A;  2OVO A;  1N13 A;  4OVO A;  1OMT A;  2NU2 I;  2KMR A;  1HPT A;  1CT0 I;  3QTL D;  2NU0 I;  2SGP I;  5JHW C;  1SGR I;  1FYB A;  1YTP A;  2SGQ I;  1UUC A;  1IY6 A;  2JYY A;  2JXD A;  2SGD I;  1UVF A;  1PJU A;  1TBR R;  1AN1 I;  3HH2 C;  2N52 A;  2QQD A;  1BMO A;  1SGY I;  1OMU A;  1NUB A;  1TUR A;  3SEK C;  2XRC A;  1OVO A;  1H0Z A;  3B4V C;  3SGQ I;  1HDL A;  1UVG A;  2KMQ A;  1PPF I;  2LEO A;  2V53 A;  3SGB I;  2SGE I;  1Z7K B;  1PCE A;  2ARP F;  1TUS A;  4GI3 C;  5DAE A;  1MT1 A;  1BUS A;  1CGJ I;  2ERW A;  2JZM A;  1M8C A;  1R0R I;  2BUS A;  2F3C I;  2NU4 I;  1CT2 I;  1OYV I;  1LR9 A;  1CHO I;  1CT4 I;  1IY5 A;  1SGD I;  2SGF I;  4SGB I;  2P6A C;  2M5X A;  3TJQ A;  1IW4 A;  1TGS I;  1SGE I;  2WCY A;  2B0U C;  2NU3 I;  1CE3 A; 
#chains in the Genus database with same CATH topology
 1TBQ R;  1SGQ I;  5HQ8 A;  1KBE A;  1LR7 A;  2OZU A;  4FKD A;  1CGI I;  4JCV E;  2GKR I;  1ULN A;  2DB6 A;  2GVI A;  2KCX A;  2N71 A;  1FAQ A;  5E3P A;  3TO7 A;  1Y8F A;  2GKT I;  2NU1 I;  5FUY A;  1DS3 I;  2CJS C;  2WGC A;  1P9G A;  2W0T A;  3R5C A;  3QWP A;  1Y1B A;  1NXU A;  2L7X A;  2KMP A;  1LR8 A;  1YU6 C;  5CCM A;  3VDU A;  1SGN I;  1CSO I;  2LUY A;  2DKV A;  3VDP A;  1TIH A;  3CXL A;  2GKV A;  2B8T A;  2ORW A;  2QPO A;  1MJB A;  3UEJ A;  5J8C A;  1VDD A;  2ODD A;  2KMO A;  1S20 A;  2K9H A;  2VRW B;  5FUX A;  1KMA A;  1K7U A;  1DS2 I;  3FSX A;  5FUW A;  1ULM A;  2UVO A;  2JW6 A;  2QQC A;  1WGT A;  3OXF A;  5J8F A;  2N17 A;  1Y1C A;  3QAH A;  3OL0 A;  4UXI A;  1SGP I;  3OVO A;  1XX6 A;  2ROW A;  9WGA A;  3GOX A;  1P9Z A;  5E3Q A;  2LB7 A;  4WP4 A;  1U5K A;  5HI7 A;  1HJA I;  4HGU A;  1M8B A;  2ORV A;  3UGI A;  2OVO A;  2V1C A;  3UEY A;  1N13 A;  4OVO A;  4E1P A;  5CCL A;  3KY9 A;  2J87 A;  1OMT A;  3OXG A;  2NU2 I;  2KMR A;  2PQ8 A;  2QQE A;  1HPT A;  1W4R A;  2OU2 A;  1CT0 I;  4UXH A;  2CWH A;  3QTL D;  2NU0 I;  2X3T A;  5EX0 A;  2SGP I;  5JHW C;  4L9M A;  1FY7 A;  1SGR I;  2UZ3 A;  2DIP A;  1FYB A;  2V1C C;  1YTP A;  1TBN A;  2SGQ I;  3MEK A;  1UUC A;  1IY6 A;  2ELI A;  2JXD A;  2JYY A;  2SGD I;  1UVF A;  1PJU A;  1TBR R;  1WKX A;  3FSY A;  3VE5 A;  1AN1 I;  3HH2 C;  3R5D A;  2N52 A;  4E1R A;  2JA1 A;  2QQD A;  2CWG A;  4A24 A;  2ENN A;  5E3R A;  2ENZ A;  1BMO A;  2A20 A;  2YQP A;  1SGY I;  2Y0M A;  1OMU A;  1NUB A;  1TUR A;  2OD1 A;  3SEK C;  1MJA A;  2XRC A;  1OVO A;  1WTJ A;  1H0Z A;  1PTR A;  2E73 A;  3B4V C;  3TO9 A;  3R5B A;  3SGQ I;  1HDL A;  5EX3 A;  3TOB A;  5FUV A;  1UVG A;  2L8E A;  2KMQ A;  1PPF I;  4MPI A;  2YUU A;  1MJ9 A;  2LEO A;  3E59 A;  2V53 A;  2WVJ A;  3SGB I;  2SGE I;  1Z7K B;  1PCE A;  1HEV A;  2ARP F;  2RIJ A;  1TUS A;  3E2I A;  3UGD A;  2J9R A;  1ULK A;  3RU0 A;  1Q9B A;  1V1H A;  3PDN A;  4GI3 C;  1PTQ A;  1TBO A;  4DNC A;  3UGL A;  3TO6 A;  1Z2I A;  2RC4 A;  5DAE A;  1MT1 A;  3UFF A;  1BUS A;  1CGJ I;  2ERW A;  2JZM A;  1M8C A;  1XBT A;  3TOA A;  7WGA A;  1R0R I;  3FC3 A;  2BUS A;  1W3S A;  2FNF X;  1KBF A;  2F3C I;  2N1A B;  1R79 A;  1K7V A;  1WGC A;  1V1I A;  1CT2 I;  1OYV I;  1LR9 A;  1CHO I;  1CT4 I;  1TOT A;  2NU4 I;  2QQ0 A;  1IY5 A;  2X52 A;  1UHA A;  1SGD I;  2GIV A;  1RFH A;  4UXJ A;  3D00 A;  2CWF A;  4B6D A;  2E5R A;  2SGF I;  4SGB I;  4AML A;  2P6A C;  3UOE A;  2M5X A;  3TJQ A;  1K7T A;  1IW4 A;  1TGS I;  1XA6 A;  3R5A A;  1X74 A;  1SGE I;  3OXL A;  2WCY A;  1X4S A;  2B0U C;  2NU3 I;  3BJI A;  1FAR A;  1CE3 A; 
#chains in the Genus database with same CATH homology
 1TBQ R;  1SGQ I;  5HQ8 A;  1KBE A;  1LR7 A;  4FKD A;  1CGI I;  4JCV E;  2GKR I;  2DB6 A;  2GVI A;  2KCX A;  2N71 A;  1FAQ A;  1Y8F A;  2GKT I;  2NU1 I;  5FUY A;  1DS3 I;  2CJS C;  2W0T A;  3QWP A;  1Y1B A;  2L7X A;  2KMP A;  1LR8 A;  1YU6 C;  5CCM A;  3VDU A;  1SGN I;  1CSO I;  2LUY A;  3VDP A;  1TIH A;  3CXL A;  2GKV A;  2B8T A;  2ORW A;  2QPO A;  3UEJ A;  1VDD A;  2ODD A;  2KMO A;  2VRW B;  2K9H A;  1KMA A;  5FUX A;  1DS2 I;  5FUW A;  2JW6 A;  2QQC A;  3OXF A;  2N17 A;  1Y1C A;  3OL0 A;  4UXI A;  1SGP I;  3OVO A;  1XX6 A;  2ROW A;  3GOX A;  1U5K A;  5HI7 A;  1HJA I;  4HGU A;  1M8B A;  2ORV A;  3UGI A;  2OVO A;  2V1C A;  3UEY A;  1N13 A;  4OVO A;  4E1P A;  5CCL A;  3KY9 A;  2J87 A;  1OMT A;  3OXG A;  2NU2 I;  2KMR A;  2QQE A;  1HPT A;  1W4R A;  1CT0 I;  4UXH A;  3QTL D;  2NU0 I;  5EX0 A;  2SGP I;  5JHW C;  4L9M A;  1SGR I;  2UZ3 A;  2DIP A;  1FYB A;  2V1C C;  1YTP A;  1TBN A;  2SGQ I;  3MEK A;  1UUC A;  1IY6 A;  2ELI A;  2JXD A;  2JYY A;  2SGD I;  1UVF A;  1PJU A;  1TBR R;  3VE5 A;  1AN1 I;  3HH2 C;  4E1R A;  2N52 A;  2JA1 A;  2QQD A;  4A24 A;  2ENN A;  2ENZ A;  1BMO A;  2A20 A;  2YQP A;  1SGY I;  1OMU A;  1NUB A;  1TUR A;  2OD1 A;  3SEK C;  2XRC A;  1OVO A;  1H0Z A;  1PTR A;  2E73 A;  3B4V C;  3SGQ I;  1HDL A;  5EX3 A;  5FUV A;  1UVG A;  2L8E A;  2KMQ A;  1PPF I;  2YUU A;  2LEO A;  3E59 A;  2V53 A;  2WVJ A;  3SGB I;  2SGE I;  1Z7K B;  1PCE A;  2ARP F;  3E2I A;  1TUS A;  3UGD A;  2J9R A;  3RU0 A;  4GI3 C;  1V1H A;  3PDN A;  1PTQ A;  1TBO A;  3UGL A;  5DAE A;  1MT1 A;  3UFF A;  1BUS A;  1CGJ I;  2ERW A;  2JZM A;  1M8C A;  1XBT A;  1R0R I;  3FC3 A;  2BUS A;  1W3S A;  2FNF X;  1KBF A;  2F3C I;  2N1A B;  1R79 A;  2NU4 I;  1V1I A;  1CT2 I;  1OYV I;  1LR9 A;  1CHO I;  1CT4 I;  1TOT A;  2QQ0 A;  1IY5 A;  1SGD I;  1RFH A;  4UXJ A;  3D00 A;  4B6D A;  2E5R A;  2SGF I;  4SGB I;  2P6A C;  2M5X A;  3TJQ A;  1IW4 A;  1TGS I;  1XA6 A;  1X74 A;  1SGE I;  3OXL A;  2WCY A;  1X4S A;  2B0U C;  2NU3 I;  3BJI A;  1FAR A;  1CE3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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