1TBRR

Crystal structure of insect derived double domain kazal inhibitor rhodniin in complex with thrombin
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
103
structure length
103
Chain Sequence
EGGEPCACPHALHRVCGSDGETYSNPCTLNCAKFNGKPELVKVHDGPCEPDEDEDVCQECDGDEYKPVCGSDDITYDNNCRLECASISSSPGVELKHEGPCRT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin.
pubmed rcsb
molecule tags Complex (serine protease/inhibitor)
source organism Rhodnius prolixus
molecule keywords THROMBIN
total genus 27
structure length 103
sequence length 103
chains with identical sequence S
ec nomenclature
pdb deposition date 1995-03-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
R PF00050 Kazal_1 Kazal-type serine protease inhibitor domain
R PF07648 Kazal_2 Kazal-type serine protease inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 1tbrR02
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 1tbrR01
2GKVA 1LR9A 1TGSI 2NU3I 1OMTA 1OYVI 1IW4A 2KMQA 4OVOA 1H0ZA 2WCYA 3SGQI 2JZMA 4GI3C 1CGJI 2NU0I 1R0RI 2N71A 1PCEA 2SGPI 1SGNI 2XRCA 1MT1A 1HDLA 2NU4I 1SGRI 2N17A 1HPTA 4SGBI 1SGYI 2JYYA 1CT2I 1YU6C 2P6AC 2QQDA 1HJAI 2NU1I 2NU2I 2BUSA 3SEKC 1CSOI 1LR8A 1OVOA 2V53A 2B0UC 1BUSA 2GKTI 2SGDI 4HGUA 1SGDI 2ERWA 1DS2I 1Y1BA 1LR7A 1PJUA 1TBQR 1UVFA 1PPFI 1NUBA 2N52A 3TJQA 3OVOA 1SGEI 1YTPA 1M8BA 2M5XA 1OMUA 2SGFI 3SGBI 2SGEI 1TIHA 3HH2C 5DAEA 1CT4I 1CT0I 2JXDA 1BMOA 2SGQI 2KMPA 2KMRA 1KMAA 3QTLD 1TURA 1FYBA 2ARPF 1CE3A 1AN1I 2OVOA 1CGII 2F3CI 5JHWC 1M8CA 2QQCA 2KCXA 1UVGA 1N13A 2GKRI 1Y1CA 2KMOA 1CHOI 1UUCA 1Z7KB 1TUSA 1IY5A 1DS3I 2LEOA 1IY6A 1SGQI 3B4VC 1SGPI 1TBRR
chains in the Genus database with same CATH superfamily
3TOBA 2GKVA 2ROWA 3FSYA 1LR9A 1TGSI 2NU3I 2QQEA 1OMTA 1OYVI 1IW4A 2KMQA 2QPOA 1W3SA 4MPIA 2E73A 1U5KA 2A20A 2CWFA 4OVOA 5E3PA 2B8TA 1H0ZA 2WCYA 1PTQA 3SGQI 2JZMA 3OXFA 1TBNA 4GI3C 1CGJI 2NU0I 3UEYA 4B6DA 1R0RI 5FUVA 1P9GA 5FUYA 5FUWA 4AMLA 2N71A 1UHAA 1ULNA 3VE5A 1PCEA 2SGPI 2CJSC 3TO9A 1SGNI 4E1RA 2JA1A 2V1CC 2XRCA 1R79A 1HEVA 1MT1A 2VRWB 1HDLA 1X74A 2NU4I 1SGRI 2LB7A 1S20A 3UGLA 2N17A 2N1AB 1HPTA 4SGBI 3UOEA 1WGCA 3UGDA 2ENNA 3TOAA 2RIJA 1SGYI 2L8EA 3FSXA 3QWPA 2JYYA 2ORVA 2PQ8A 1TBOA 5FUXA 1CT2I 1NXUA 1YU6C 2YUUA 3BJIA 2P6AC 2QQDA 1HJAI 2RC4A 2NU1I 3R5CA 2NU2I 2BUSA 5CCMA 1WGTA 4FKDA 3VDUA 2UZ3A 1XX6A 1KBFA 5EX0A 1P9ZA 3OXGA 3SEKC 1CSOI 1LR8A 1OVOA 2V53A 2B0UC 2CWHA 1V1IA 2OZUA 2DIPA 5E3RA 2ORWA 1BUSA 1PTRA 3UGIA 2WVJA 2GKTI 2SGDI 3MEKA 1ULKA 2ELIA 4HGUA 4WP4A 1FAQA 2GIVA 1SGDI 1Q9BA 3TO7A 1MJAA 2ERWA 1DS2I 1Y1BA 2L7XA 2J87A 1LR7A 1PJUA 1TBQR 2Y0MA 1UVFA 3D00A 2OD1A 1MJ9A 1PPFI 1NUBA 2N52A 3TJQA 3OVOA 3UEJA 1SGEI 1YTPA 3QAHA 1M8BA 2M5XA 2X52A 2YQPA 3CXLA 4JCVE 1OMUA 1XBTA 5HI7A 5HQ8A 3OXLA 2ODDA 1FY7A 2SGFI 2FNFX 3SGBI 2SGEI 3R5BA 4A24A 1MJBA 1TIHA 3HH2C 1CT4I 1CT0I 5DAEA 2JXDA 1BMOA 2SGQI 3TO6A 2KMPA 2KMRA 1Y8FA 3UFFA 1KMAA 5EX3A 3E2IA 3QTLD 1TURA 2DB6A 4UXHA 5CCLA 1FYBA 2ARPF 2LUYA 2W0TA 1CE3A 1RFHA 1AN1I 1X4SA 3PDNA 2OVOA 4L9MA 4DNCA 1CGII 2E5RA 2DKVA 2F3CI 1M8CA 2QQCA 3E59A 5JHWC 2KCXA 1UVGA 1VDDA 5J8FA 1N13A 1ULMA 2GKRI 4UXIA 3OL0A 1Y1CA 5E3QA 5J8CA 1K7VA 2CWGA 2V1CA 2KMOA 1CHOI 4UXJA 7WGAA 1UUCA 2JW6A 2OU2A 3KY9A 1WKXA 1K7TA 2X3TA 3R5DA 1Z7KB 3GOXA 9WGAA 2ENZA 1TOTA 1K7UA 1KBEA 1TUSA 2WGCA 1IY5A 2J9RA 1DS3I 1V1HA 2LEOA 1W4RA 3RU0A 1IY6A 3FC3A 1SGQI 3B4VC 1SGPI 2GVIA 2K9HA 2UVOA 3VDPA 1FARA 4E1PA 1XA6A 1WTJA 1Z2IA 2QQ0A 3R5AA 1TBRR
chains in the Genus database with same CATH topology
2GKVA 2ROWA 1LR9A 1TGSI 2NU3I 2QQEA 1OMTA 1OYVI 1IW4A 2KMQA 2QPOA 1W3SA 4OVOA 2E73A 1U5KA 2A20A 2B8TA 1H0ZA 2WCYA 1PTQA 3SGQI 2JZMA 3OXFA 1TBNA 4GI3C 1CGJI 2NU0I 3UEYA 4B6DA 1R0RI 5FUVA 5FUYA 5FUWA 2N71A 3VE5A 1PCEA 2SGPI 2CJSC 1SGNI 4E1RA 2JA1A 2V1CC 2XRCA 1R79A 1MT1A 2VRWB 1HDLA 1X74A 2NU4I 1SGRI 3UGLA 2N17A 2N1AB 1HPTA 4SGBI 3UGDA 2ENNA 1SGYI 2L8EA 3QWPA 2JYYA 2ORVA 5FUXA 1TBOA 1CT2I 2YUUA 1YU6C 3BJIA 2P6AC 2QQDA 1HJAI 2NU1I 2NU2I 2BUSA 5CCMA 4FKDA 3VDUA 2UZ3A 1XX6A 1KBFA 5EX0A 3OXGA 3SEKC 1CSOI 1LR8A 1OVOA 2V53A 2B0UC 1V1IA 2DIPA 1BUSA 2ORWA 1PTRA 3UGIA 2WVJA 2GKTI 2SGDI 3MEKA 2ELIA 4HGUA 1SGDI 2ERWA 1DS2I 1Y1BA 2L7XA 2J87A 1LR7A 1PJUA 1TBQR 1UVFA 3D00A 2OD1A 1PPFI 1NUBA 2N52A 3TJQA 3OVOA 3UEJA 1SGEI 1YTPA 1M8BA 2M5XA 2YQPA 3CXLA 4JCVE 1OMUA 1XBTA 5HI7A 5HQ8A 3OXLA 2ODDA 2SGFI 2FNFX 3SGBI 2SGEI 4A24A 1TIHA 3HH2C 5DAEA 1CT4I 1CT0I 2JXDA 1BMOA 2SGQI 3UFFA 2KMPA 2KMRA 1Y8FA 1KMAA 5EX3A 3E2IA 3QTLD 1TURA 2DB6A 4UXHA 5CCLA 1FYBA 2ARPF 2LUYA 2W0TA 1CE3A 1RFHA 1AN1I 1X4SA 3PDNA 2OVOA 4L9MA 1CGII 2E5RA 2F3CI 5JHWC 1M8CA 2QQCA 3E59A 2KCXA 1UVGA 1VDDA 1N13A 2GKRI 4UXIA 3OL0A 1Y1CA 4UXJA 2V1CA 2KMOA 1CHOI 1FAQA 1UUCA 2JW6A 3KY9A 1Z7KB 3GOXA 2ENZA 1TOTA 1TUSA 1KBEA 1IY5A 2J9RA 1DS3I 1V1HA 2LEOA 1W4RA 3RU0A 1IY6A 3FC3A 1SGQI 3B4VC 1SGPI 2GVIA 2K9HA 3VDPA 1FARA 4E1PA 1XA6A 2QQ0A 1TBRR
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GKV A;  1LR9 A;  1TGS I;  2NU3 I;  1OMT A;  1OYV I;  1IW4 A;  2KMQ A;  4OVO A;  1H0Z A;  2WCY A;  3SGQ I;  2JZM A;  4GI3 C;  1CGJ I;  2NU0 I;  1R0R I;  2N71 A;  1PCE A;  2SGP I;  1SGN I;  2XRC A;  1MT1 A;  1HDL A;  2NU4 I;  1SGR I;  2N17 A;  1HPT A;  4SGB I;  1SGY I;  2JYY A;  1CT2 I;  1YU6 C;  2P6A C;  2QQD A;  1HJA I;  2NU1 I;  2NU2 I;  2BUS A;  3SEK C;  1CSO I;  1LR8 A;  1OVO A;  2V53 A;  2B0U C;  1BUS A;  2GKT I;  2SGD I;  4HGU A;  1SGD I;  2ERW A;  1DS2 I;  1Y1B A;  1LR7 A;  1PJU A;  1TBQ R;  1UVF A;  1PPF I;  1NUB A;  2N52 A;  3TJQ A;  3OVO A;  1SGE I;  1YTP A;  1M8B A;  2M5X A;  1OMU A;  2SGF I;  3SGB I;  2SGE I;  1TIH A;  3HH2 C;  5DAE A;  1CT4 I;  1CT0 I;  2JXD A;  1BMO A;  2SGQ I;  2KMP A;  2KMR A;  1KMA A;  3QTL D;  1TUR A;  1FYB A;  2ARP F;  1CE3 A;  1AN1 I;  2OVO A;  1CGI I;  2F3C I;  5JHW C;  1M8C A;  2QQC A;  2KCX A;  1UVG A;  1N13 A;  2GKR I;  1Y1C A;  2KMO A;  1CHO I;  1UUC A;  1Z7K B;  1TUS A;  1IY5 A;  1DS3 I;  2LEO A;  1IY6 A;  1SGQ I;  3B4V C;  1SGP I;  1TBR R; 
#chains in the Genus database with same CATH topology
 3TOB A;  2GKV A;  2ROW A;  3FSY A;  1LR9 A;  1TGS I;  2NU3 I;  2QQE A;  1OMT A;  1OYV I;  1IW4 A;  2KMQ A;  2QPO A;  1W3S A;  4MPI A;  2E73 A;  1U5K A;  2A20 A;  2CWF A;  4OVO A;  5E3P A;  2B8T A;  1H0Z A;  2WCY A;  1PTQ A;  3SGQ I;  2JZM A;  3OXF A;  1TBN A;  4GI3 C;  1CGJ I;  2NU0 I;  3UEY A;  4B6D A;  1R0R I;  5FUV A;  1P9G A;  5FUY A;  5FUW A;  4AML A;  2N71 A;  1UHA A;  1ULN A;  3VE5 A;  1PCE A;  2SGP I;  2CJS C;  3TO9 A;  1SGN I;  4E1R A;  2JA1 A;  2V1C C;  2XRC A;  1R79 A;  1HEV A;  1MT1 A;  2VRW B;  1HDL A;  1X74 A;  2NU4 I;  1SGR I;  2LB7 A;  1S20 A;  3UGL A;  2N17 A;  2N1A B;  1HPT A;  4SGB I;  3UOE A;  1WGC A;  3UGD A;  2ENN A;  3TOA A;  2RIJ A;  1SGY I;  2L8E A;  3FSX A;  3QWP A;  2JYY A;  2ORV A;  2PQ8 A;  1TBO A;  5FUX A;  1CT2 I;  1NXU A;  1YU6 C;  2YUU A;  3BJI A;  2P6A C;  2QQD A;  1HJA I;  2RC4 A;  2NU1 I;  3R5C A;  2NU2 I;  2BUS A;  5CCM A;  1WGT A;  4FKD A;  3VDU A;  2UZ3 A;  1XX6 A;  1KBF A;  5EX0 A;  1P9Z A;  3OXG A;  3SEK C;  1CSO I;  1LR8 A;  1OVO A;  2V53 A;  2B0U C;  2CWH A;  1V1I A;  2OZU A;  2DIP A;  5E3R A;  2ORW A;  1BUS A;  1PTR A;  3UGI A;  2WVJ A;  2GKT I;  2SGD I;  3MEK A;  1ULK A;  2ELI A;  4HGU A;  4WP4 A;  1FAQ A;  2GIV A;  1SGD I;  1Q9B A;  3TO7 A;  1MJA A;  2ERW A;  1DS2 I;  1Y1B A;  2L7X A;  2J87 A;  1LR7 A;  1PJU A;  1TBQ R;  2Y0M A;  1UVF A;  3D00 A;  2OD1 A;  1MJ9 A;  1PPF I;  1NUB A;  2N52 A;  3TJQ A;  3OVO A;  3UEJ A;  1SGE I;  1YTP A;  3QAH A;  1M8B A;  2M5X A;  2X52 A;  2YQP A;  3CXL A;  4JCV E;  1OMU A;  1XBT A;  5HI7 A;  5HQ8 A;  3OXL A;  2ODD A;  1FY7 A;  2SGF I;  2FNF X;  3SGB I;  2SGE I;  3R5B A;  4A24 A;  1MJB A;  1TIH A;  3HH2 C;  1CT4 I;  1CT0 I;  5DAE A;  2JXD A;  1BMO A;  2SGQ I;  3TO6 A;  2KMP A;  2KMR A;  1Y8F A;  3UFF A;  1KMA A;  5EX3 A;  3E2I A;  3QTL D;  1TUR A;  2DB6 A;  4UXH A;  5CCL A;  1FYB A;  2ARP F;  2LUY A;  2W0T A;  1CE3 A;  1RFH A;  1AN1 I;  1X4S A;  3PDN A;  2OVO A;  4L9M A;  4DNC A;  1CGI I;  2E5R A;  2DKV A;  2F3C I;  1M8C A;  2QQC A;  3E59 A;  5JHW C;  2KCX A;  1UVG A;  1VDD A;  5J8F A;  1N13 A;  1ULM A;  2GKR I;  4UXI A;  3OL0 A;  1Y1C A;  5E3Q A;  5J8C A;  1K7V A;  2CWG A;  2V1C A;  2KMO A;  1CHO I;  4UXJ A;  7WGA A;  1UUC A;  2JW6 A;  2OU2 A;  3KY9 A;  1WKX A;  1K7T A;  2X3T A;  3R5D A;  1Z7K B;  3GOX A;  9WGA A;  2ENZ A;  1TOT A;  1K7U A;  1KBE A;  1TUS A;  2WGC A;  1IY5 A;  2J9R A;  1DS3 I;  1V1H A;  2LEO A;  1W4R A;  3RU0 A;  1IY6 A;  3FC3 A;  1SGQ I;  3B4V C;  1SGP I;  2GVI A;  2K9H A;  2UVO A;  3VDP A;  1FAR A;  4E1P A;  1XA6 A;  1WTJ A;  1Z2I A;  2QQ0 A;  3R5A A;  1TBR R; 
#chains in the Genus database with same CATH homology
 2GKV A;  2ROW A;  1LR9 A;  1TGS I;  2NU3 I;  2QQE A;  1OMT A;  1OYV I;  1IW4 A;  2KMQ A;  2QPO A;  1W3S A;  4OVO A;  2E73 A;  1U5K A;  2A20 A;  2B8T A;  1H0Z A;  2WCY A;  1PTQ A;  3SGQ I;  2JZM A;  3OXF A;  1TBN A;  4GI3 C;  1CGJ I;  2NU0 I;  3UEY A;  4B6D A;  1R0R I;  5FUV A;  5FUY A;  5FUW A;  2N71 A;  3VE5 A;  1PCE A;  2SGP I;  2CJS C;  1SGN I;  4E1R A;  2JA1 A;  2V1C C;  2XRC A;  1R79 A;  1MT1 A;  2VRW B;  1HDL A;  1X74 A;  2NU4 I;  1SGR I;  3UGL A;  2N17 A;  2N1A B;  1HPT A;  4SGB I;  3UGD A;  2ENN A;  1SGY I;  2L8E A;  3QWP A;  2JYY A;  2ORV A;  5FUX A;  1TBO A;  1CT2 I;  2YUU A;  1YU6 C;  3BJI A;  2P6A C;  2QQD A;  1HJA I;  2NU1 I;  2NU2 I;  2BUS A;  5CCM A;  4FKD A;  3VDU A;  2UZ3 A;  1XX6 A;  1KBF A;  5EX0 A;  3OXG A;  3SEK C;  1CSO I;  1LR8 A;  1OVO A;  2V53 A;  2B0U C;  1V1I A;  2DIP A;  1BUS A;  2ORW A;  1PTR A;  3UGI A;  2WVJ A;  2GKT I;  2SGD I;  3MEK A;  2ELI A;  4HGU A;  1SGD I;  2ERW A;  1DS2 I;  1Y1B A;  2L7X A;  2J87 A;  1LR7 A;  1PJU A;  1TBQ R;  1UVF A;  3D00 A;  2OD1 A;  1PPF I;  1NUB A;  2N52 A;  3TJQ A;  3OVO A;  3UEJ A;  1SGE I;  1YTP A;  1M8B A;  2M5X A;  2YQP A;  3CXL A;  4JCV E;  1OMU A;  1XBT A;  5HI7 A;  5HQ8 A;  3OXL A;  2ODD A;  2SGF I;  2FNF X;  3SGB I;  2SGE I;  4A24 A;  1TIH A;  3HH2 C;  5DAE A;  1CT4 I;  1CT0 I;  2JXD A;  1BMO A;  2SGQ I;  3UFF A;  2KMP A;  2KMR A;  1Y8F A;  1KMA A;  5EX3 A;  3E2I A;  3QTL D;  1TUR A;  2DB6 A;  4UXH A;  5CCL A;  1FYB A;  2ARP F;  2LUY A;  2W0T A;  1CE3 A;  1RFH A;  1AN1 I;  1X4S A;  3PDN A;  2OVO A;  4L9M A;  1CGI I;  2E5R A;  2F3C I;  5JHW C;  1M8C A;  2QQC A;  3E59 A;  2KCX A;  1UVG A;  1VDD A;  1N13 A;  2GKR I;  4UXI A;  3OL0 A;  1Y1C A;  4UXJ A;  2V1C A;  2KMO A;  1CHO I;  1FAQ A;  1UUC A;  2JW6 A;  3KY9 A;  1Z7K B;  3GOX A;  2ENZ A;  1TOT A;  1TUS A;  1KBE A;  1IY5 A;  2J9R A;  1DS3 I;  1V1H A;  2LEO A;  1W4R A;  3RU0 A;  1IY6 A;  3FC3 A;  1SGQ I;  3B4V C;  1SGP I;  2GVI A;  2K9H A;  3VDP A;  1FAR A;  4E1P A;  1XA6 A;  2QQ0 A;  1TBR R; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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