2F3CI

Crystal structure of infestin 1, a kazal-type serineprotease inhibitor, in complex with trypsin
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
46
structure length
46
Chain Sequence
DCACPRVLHRVCGSDGNTYSNPCTLDCAKHEGKPDLVQVHEGPCDP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Kazal-type inhibitors infestins 1 and 4 differ in specificity but are similar in three-dimensional structure.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Triatoma infestans
molecule keywords Cationic trypsin
total genus 14
structure length 46
sequence length 46
ec nomenclature
pdb deposition date 2005-11-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00050 Kazal_1 Kazal-type serine protease inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 2f3cI00
1DS2I 2SGFI 1HPTA 1H0ZA 1FYBA 1UVGA 1OYVI 1M8BA 2KMPA 2N17A 1OMTA 2QQCA 1MT1A 2NU1I 3TJQA 2WCYA 2B0UC 2LEOA 1Y1BA 3QTLD 1BUSA 1OMUA 1M8CA 1R0RI 1N13A 2N52A 2JXDA 2SGDI 1SGYI 2NU4I 1TBQR 1CT0I 1YTPA 1CSOI 3B4VC 2GKVA 4OVOA 1KMAA 1DS3I 1NUBA 4SGBI 1SGNI 2ARPF 2ERWA 1LR7A 1CT2I 1Z7KB 3HH2C 2M5XA 1SGDI 2OVOA 1SGPI 1AN1I 1BMOA 1PCEA 2NU2I 3OVOA 1SGRI 2NU0I 1TURA 2P6AC 5DAEA 2SGPI 2V53A 2JYYA 3SGBI 3SEKC 1CGII 1IW4A 1YU6C 2GKRI 2QQDA 1PPFI 1Y1CA 2SGEI 2NU3I 1TGSI 2KCXA 2KMOA 1LR8A 4HGUA 1HJAI 1HDLA 1CHOI 2KMRA 4GI3C 2N71A 1LR9A 2JZMA 1IY5A 5JHWC 1IY6A 1SGQI 1PJUA 1UUCA 2BUSA 1UVFA 1OVOA 1CGJI 1SGEI 2XRCA 2SGQI 1TIHA 2KMQA 1CT4I 1TBRR 1CE3A 1TUSA 2GKTI 3SGQI 2F3CI
chains in the Genus database with same CATH superfamily
1DS2I 2SGFI 3TO9A 1HPTA 1H0ZA 3QAHA 1FYBA 4L9MA 1UVGA 3UFFA 3TO7A 2OD1A 2ROWA 2WGCA 5FUVA 1KBFA 2ENNA 2ENZA 1U5KA 5FUWA 2GIVA 3BJIA 3TO6A 3MEKA 1OYVI 1NXUA 5HQ8A 1XX6A 1M8BA 3UOEA 2KMPA 2ORVA 3OL0A 1KBEA 1TOTA 2J87A 2N17A 2OU2A 2CWHA 5J8FA 3E2IA 2E5RA 1OMTA 2CWGA 1TBNA 2L8EA 2QQCA 4UXHA 1MT1A 2NU1I 3TJQA 1PTRA 2WCYA 1VDDA 2E73A 1FY7A 1P9ZA 2B0UC 2X3TA 2LEOA 1PTQA 1Y1BA 2WVJA 1HEVA 3QTLD 2LUYA 3UGIA 1BUSA 1OMUA 1K7VA 2V1CC 1FARA 2CJSC 4AMLA 4JCVE 3UEJA 1W3SA 4B6DA 3GOXA 1WKXA 2UZ3A 1WGCA 1M8CA 1R0RI 2JA1A 1N13A 1V1IA 1XA6A 2N52A 2JXDA 2X52A 2SGDI 5E3PA 1SGYI 2NU4I 1TBQR 2VRWB 5EX3A 3VDPA 1MJ9A 1ULNA 1CT0I 1YTPA 2Y0MA 4E1RA 1CSOI 3B4VC 3TOAA 4MPIA 2GKVA 4OVOA 1Q9BA 2OZUA 3R5CA 1TBOA 1DS3I 1NUBA 4SGBI 3UGLA 1ULMA 1KMAA 1P9GA 1SGNI 2YQPA 2LB7A 2ARPF 2ERWA 3OXGA 1K7TA 1LR7A 5CCLA 1CT2I 1Z7KB 1MJAA 1WTJA 3HH2C 3OXFA 3TOBA 2M5XA 1SGDI 2ELIA 1UHAA 2OVOA 3VDUA 3R5BA 1SGPI 1AN1I 1BMOA 3UGDA 1FAQA 1RFHA 1PCEA 2NU2I 3FSYA 3OVOA 5FUYA 3FC3A 2QPOA 4A24A 1Y8FA 1SGRI 2NU0I 3FSXA 1TURA 2P6AC 5DAEA 5FUXA 2YUUA 2UVOA 2SGPI 1S20A 2QQ0A 2JYYA 2V53A 3E59A 1R79A 1Z2IA 3SGBI 3SEKC 3CXLA 1CGII 1IW4A 2DB6A 1YU6C 4DNCA 3UEYA 2GKRI 2QQDA 2J9RA 2RC4A 2RIJA 1PPFI 1Y1CA 2L7XA 1XBTA 2SGEI 5J8CA 2NU3I 4UXIA 2A20A 1TGSI 2DIPA 1X4SA 2KCXA 3R5AA 2KMOA 1LR8A 4WP4A 7WGAA 3OXLA 3RU0A 3QWPA 1WGTA 3D00A 2QQEA 4HGUA 1HJAI 2CWFA 4UXJA 1HDLA 2GVIA 5EX0A 1CHOI 2KMRA 4GI3C 5E3RA 3SGQI 5E3QA 2N71A 2W0TA 1LR9A 2JZMA 9WGAA 1IY5A 2JW6A 5JHWC 1IY6A 1SGQI 1PJUA 1UUCA 3VE5A 2N1AB 2BUSA 1UVFA 1OVOA 2DKVA 1CGJI 1SGEI 2V1CA 2XRCA 3R5DA 5HI7A 1W4RA 2B8TA 2PQ8A 2SGQI 1V1HA 1TIHA 2FNFX 2KMQA 2ORWA 1CT4I 3KY9A 5CCMA 1K7UA 4E1PA 1TBRR 1MJBA 1X74A 4FKDA 1CE3A 1TUSA 3PDNA 2ODDA 2GKTI 2K9HA 1ULKA 2F3CI
chains in the Genus database with same CATH topology
1DS2I 2SGFI 1HPTA 1H0ZA 1FYBA 4L9MA 1UVGA 3UFFA 2OD1A 2ROWA 5FUVA 1KBFA 2ENNA 2ENZA 1U5KA 5FUWA 3BJIA 3MEKA 1OYVI 5HQ8A 1XX6A 1M8BA 2KMPA 2ORVA 3OL0A 1KBEA 1TOTA 2J87A 2N17A 3E2IA 2E5RA 1OMTA 2QQCA 1TBNA 2L8EA 4UXHA 1MT1A 2NU1I 3TJQA 1PTRA 2WCYA 1VDDA 2E73A 2B0UC 2LEOA 1PTQA 1Y1BA 2WVJA 3QTLD 2LUYA 3UGIA 1BUSA 1OMUA 2V1CC 2CJSC 1FARA 4B6DA 4JCVE 3UEJA 1W3SA 3GOXA 2UZ3A 1M8CA 1R0RI 2JA1A 1N13A 1V1IA 1XA6A 2N52A 2JXDA 2SGDI 1SGYI 2NU4I 1TBQR 2VRWB 5EX3A 3VDPA 1CT0I 1YTPA 4E1RA 1CSOI 3B4VC 2GKVA 4OVOA 1TBOA 1DS3I 1NUBA 4SGBI 3UGLA 1KMAA 1SGNI 2YQPA 2ARPF 2ERWA 3OXGA 1LR7A 5CCLA 1CT2I 1Z7KB 3OXFA 3HH2C 2M5XA 1SGDI 2ELIA 2OVOA 3VDUA 1SGPI 1AN1I 1BMOA 3UGDA 1FAQA 1RFHA 1PCEA 2NU2I 3OVOA 3FC3A 5FUYA 2QPOA 4A24A 1Y8FA 1SGRI 2NU0I 1TURA 2P6AC 5DAEA 5FUXA 2YUUA 2SGPI 3E59A 2QQ0A 2JYYA 2V53A 1R79A 3SGBI 3SEKC 3CXLA 1CGII 1IW4A 2DB6A 1YU6C 3UEYA 2GKRI 2QQDA 2J9RA 1PPFI 1Y1CA 2L7XA 1XBTA 2SGEI 2NU3I 4UXIA 2A20A 1TGSI 2DIPA 1X4SA 2KCXA 2KMOA 1LR8A 3OXLA 3RU0A 3QWPA 3D00A 2QQEA 4HGUA 1HJAI 4UXJA 1HDLA 2GVIA 5EX0A 1CHOI 2KMRA 4GI3C 2N71A 2W0TA 1LR9A 2JZMA 1IY5A 2JW6A 5JHWC 1IY6A 1SGQI 1PJUA 1UUCA 3VE5A 2N1AB 2BUSA 1UVFA 1OVOA 2V1CA 1CGJI 1SGEI 2XRCA 5HI7A 1W4RA 2B8TA 2SGQI 1V1HA 1TIHA 2FNFX 2KMQA 2ORWA 1CT4I 3KY9A 5CCMA 4E1PA 1TBRR 1X74A 4FKDA 1CE3A 1TUSA 3PDNA 2ODDA 2GKTI 2K9HA 3SGQI 2F3CI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DS2 I;  2SGF I;  1HPT A;  1H0Z A;  1FYB A;  1UVG A;  1OYV I;  1M8B A;  2KMP A;  2N17 A;  1OMT A;  2QQC A;  1MT1 A;  2NU1 I;  3TJQ A;  2WCY A;  2B0U C;  2LEO A;  1Y1B A;  3QTL D;  1BUS A;  1OMU A;  1M8C A;  1R0R I;  1N13 A;  2N52 A;  2JXD A;  2SGD I;  1SGY I;  2NU4 I;  1TBQ R;  1CT0 I;  1YTP A;  1CSO I;  3B4V C;  2GKV A;  4OVO A;  1KMA A;  1DS3 I;  1NUB A;  4SGB I;  1SGN I;  2ARP F;  2ERW A;  1LR7 A;  1CT2 I;  1Z7K B;  3HH2 C;  2M5X A;  1SGD I;  2OVO A;  1SGP I;  1AN1 I;  1BMO A;  1PCE A;  2NU2 I;  3OVO A;  1SGR I;  2NU0 I;  1TUR A;  2P6A C;  5DAE A;  2SGP I;  2V53 A;  2JYY A;  3SGB I;  3SEK C;  1CGI I;  1IW4 A;  1YU6 C;  2GKR I;  2QQD A;  1PPF I;  1Y1C A;  2SGE I;  2NU3 I;  1TGS I;  2KCX A;  2KMO A;  1LR8 A;  4HGU A;  1HJA I;  1HDL A;  1CHO I;  2KMR A;  4GI3 C;  2N71 A;  1LR9 A;  2JZM A;  1IY5 A;  5JHW C;  1IY6 A;  1SGQ I;  1PJU A;  1UUC A;  2BUS A;  1UVF A;  1OVO A;  1CGJ I;  1SGE I;  2XRC A;  2SGQ I;  1TIH A;  2KMQ A;  1CT4 I;  1TBR R;  1CE3 A;  1TUS A;  2GKT I;  3SGQ I;  2F3C I; 
#chains in the Genus database with same CATH topology
 1DS2 I;  2SGF I;  3TO9 A;  1HPT A;  1H0Z A;  3QAH A;  1FYB A;  4L9M A;  1UVG A;  3UFF A;  3TO7 A;  2OD1 A;  2ROW A;  2WGC A;  5FUV A;  1KBF A;  2ENN A;  2ENZ A;  1U5K A;  5FUW A;  2GIV A;  3BJI A;  3TO6 A;  3MEK A;  1OYV I;  1NXU A;  5HQ8 A;  1XX6 A;  1M8B A;  3UOE A;  2KMP A;  2ORV A;  3OL0 A;  1KBE A;  1TOT A;  2J87 A;  2N17 A;  2OU2 A;  2CWH A;  5J8F A;  3E2I A;  2E5R A;  1OMT A;  2CWG A;  1TBN A;  2L8E A;  2QQC A;  4UXH A;  1MT1 A;  2NU1 I;  3TJQ A;  1PTR A;  2WCY A;  1VDD A;  2E73 A;  1FY7 A;  1P9Z A;  2B0U C;  2X3T A;  2LEO A;  1PTQ A;  1Y1B A;  2WVJ A;  1HEV A;  3QTL D;  2LUY A;  3UGI A;  1BUS A;  1OMU A;  1K7V A;  2V1C C;  1FAR A;  2CJS C;  4AML A;  4JCV E;  3UEJ A;  1W3S A;  4B6D A;  3GOX A;  1WKX A;  2UZ3 A;  1WGC A;  1M8C A;  1R0R I;  2JA1 A;  1N13 A;  1V1I A;  1XA6 A;  2N52 A;  2JXD A;  2X52 A;  2SGD I;  5E3P A;  1SGY I;  2NU4 I;  1TBQ R;  2VRW B;  5EX3 A;  3VDP A;  1MJ9 A;  1ULN A;  1CT0 I;  1YTP A;  2Y0M A;  4E1R A;  1CSO I;  3B4V C;  3TOA A;  4MPI A;  2GKV A;  4OVO A;  1Q9B A;  2OZU A;  3R5C A;  1TBO A;  1DS3 I;  1NUB A;  4SGB I;  3UGL A;  1ULM A;  1KMA A;  1P9G A;  1SGN I;  2YQP A;  2LB7 A;  2ARP F;  2ERW A;  3OXG A;  1K7T A;  1LR7 A;  5CCL A;  1CT2 I;  1Z7K B;  1MJA A;  1WTJ A;  3HH2 C;  3OXF A;  3TOB A;  2M5X A;  1SGD I;  2ELI A;  1UHA A;  2OVO A;  3VDU A;  3R5B A;  1SGP I;  1AN1 I;  1BMO A;  3UGD A;  1FAQ A;  1RFH A;  1PCE A;  2NU2 I;  3FSY A;  3OVO A;  5FUY A;  3FC3 A;  2QPO A;  4A24 A;  1Y8F A;  1SGR I;  2NU0 I;  3FSX A;  1TUR A;  2P6A C;  5DAE A;  5FUX A;  2YUU A;  2UVO A;  2SGP I;  1S20 A;  2QQ0 A;  2JYY A;  2V53 A;  3E59 A;  1R79 A;  1Z2I A;  3SGB I;  3SEK C;  3CXL A;  1CGI I;  1IW4 A;  2DB6 A;  1YU6 C;  4DNC A;  3UEY A;  2GKR I;  2QQD A;  2J9R A;  2RC4 A;  2RIJ A;  1PPF I;  1Y1C A;  2L7X A;  1XBT A;  2SGE I;  5J8C A;  2NU3 I;  4UXI A;  2A20 A;  1TGS I;  2DIP A;  1X4S A;  2KCX A;  3R5A A;  2KMO A;  1LR8 A;  4WP4 A;  7WGA A;  3OXL A;  3RU0 A;  3QWP A;  1WGT A;  3D00 A;  2QQE A;  4HGU A;  1HJA I;  2CWF A;  4UXJ A;  1HDL A;  2GVI A;  5EX0 A;  1CHO I;  2KMR A;  4GI3 C;  5E3R A;  3SGQ I;  5E3Q A;  2N71 A;  2W0T A;  1LR9 A;  2JZM A;  9WGA A;  1IY5 A;  2JW6 A;  5JHW C;  1IY6 A;  1SGQ I;  1PJU A;  1UUC A;  3VE5 A;  2N1A B;  2BUS A;  1UVF A;  1OVO A;  2DKV A;  1CGJ I;  1SGE I;  2V1C A;  2XRC A;  3R5D A;  5HI7 A;  1W4R A;  2B8T A;  2PQ8 A;  2SGQ I;  1V1H A;  1TIH A;  2FNF X;  2KMQ A;  2ORW A;  1CT4 I;  3KY9 A;  5CCM A;  1K7U A;  4E1P A;  1TBR R;  1MJB A;  1X74 A;  4FKD A;  1CE3 A;  1TUS A;  3PDN A;  2ODD A;  2GKT I;  2K9H A;  1ULK A;  2F3C I; 
#chains in the Genus database with same CATH homology
 1DS2 I;  2SGF I;  1HPT A;  1H0Z A;  1FYB A;  4L9M A;  1UVG A;  3UFF A;  2OD1 A;  2ROW A;  5FUV A;  1KBF A;  2ENN A;  2ENZ A;  1U5K A;  5FUW A;  3BJI A;  3MEK A;  1OYV I;  5HQ8 A;  1XX6 A;  1M8B A;  2KMP A;  2ORV A;  3OL0 A;  1KBE A;  1TOT A;  2J87 A;  2N17 A;  3E2I A;  2E5R A;  1OMT A;  2QQC A;  1TBN A;  2L8E A;  4UXH A;  1MT1 A;  2NU1 I;  3TJQ A;  1PTR A;  2WCY A;  1VDD A;  2E73 A;  2B0U C;  2LEO A;  1PTQ A;  1Y1B A;  2WVJ A;  3QTL D;  2LUY A;  3UGI A;  1BUS A;  1OMU A;  2V1C C;  2CJS C;  1FAR A;  4B6D A;  4JCV E;  3UEJ A;  1W3S A;  3GOX A;  2UZ3 A;  1M8C A;  1R0R I;  2JA1 A;  1N13 A;  1V1I A;  1XA6 A;  2N52 A;  2JXD A;  2SGD I;  1SGY I;  2NU4 I;  1TBQ R;  2VRW B;  5EX3 A;  3VDP A;  1CT0 I;  1YTP A;  4E1R A;  1CSO I;  3B4V C;  2GKV A;  4OVO A;  1TBO A;  1DS3 I;  1NUB A;  4SGB I;  3UGL A;  1KMA A;  1SGN I;  2YQP A;  2ARP F;  2ERW A;  3OXG A;  1LR7 A;  5CCL A;  1CT2 I;  1Z7K B;  3OXF A;  3HH2 C;  2M5X A;  1SGD I;  2ELI A;  2OVO A;  3VDU A;  1SGP I;  1AN1 I;  1BMO A;  3UGD A;  1FAQ A;  1RFH A;  1PCE A;  2NU2 I;  3OVO A;  3FC3 A;  5FUY A;  2QPO A;  4A24 A;  1Y8F A;  1SGR I;  2NU0 I;  1TUR A;  2P6A C;  5DAE A;  5FUX A;  2YUU A;  2SGP I;  3E59 A;  2QQ0 A;  2JYY A;  2V53 A;  1R79 A;  3SGB I;  3SEK C;  3CXL A;  1CGI I;  1IW4 A;  2DB6 A;  1YU6 C;  3UEY A;  2GKR I;  2QQD A;  2J9R A;  1PPF I;  1Y1C A;  2L7X A;  1XBT A;  2SGE I;  2NU3 I;  4UXI A;  2A20 A;  1TGS I;  2DIP A;  1X4S A;  2KCX A;  2KMO A;  1LR8 A;  3OXL A;  3RU0 A;  3QWP A;  3D00 A;  2QQE A;  4HGU A;  1HJA I;  4UXJ A;  1HDL A;  2GVI A;  5EX0 A;  1CHO I;  2KMR A;  4GI3 C;  2N71 A;  2W0T A;  1LR9 A;  2JZM A;  1IY5 A;  2JW6 A;  5JHW C;  1IY6 A;  1SGQ I;  1PJU A;  1UUC A;  3VE5 A;  2N1A B;  2BUS A;  1UVF A;  1OVO A;  2V1C A;  1CGJ I;  1SGE I;  2XRC A;  5HI7 A;  1W4R A;  2B8T A;  2SGQ I;  1V1H A;  1TIH A;  2FNF X;  2KMQ A;  2ORW A;  1CT4 I;  3KY9 A;  5CCM A;  4E1P A;  1TBR R;  1X74 A;  4FKD A;  1CE3 A;  1TUS A;  3PDN A;  2ODD A;  2GKT I;  2K9H A;  3SGQ I;  2F3C I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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