2KMPA

Solution structure of intermeidate iia of leeck-derived tryptase inhibitor, ldti.
Total Genus 6
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
6
sequence length
44
structure length
44
Chain Sequence
KKVCACPKILKPVCGSDGRTYANSCIARCNGVSIKSEGSCPTGI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Deciphering the structural basis that guides the oxidative folding of leech-derived tryptase inhibitor.
pubmed doi rcsb
molecule tags Hydrolase
source organism Hirudo medicinalis
molecule keywords Leech-derived tryptase inhibitor C
total genus 6
structure length 44
sequence length 44
ec nomenclature
pdb deposition date 2009-08-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00050 Kazal_1 Kazal-type serine protease inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 2kmpA00
2NU3I 1FYBA 1PPFI 2KMRA 2XRCA 2BUSA 3OVOA 2KMPA 1SGNI 1M8BA 1PJUA 1PCEA 1SGDI 1SGEI 1UUCA 1Y1BA 1N13A 1IY5A 1H0ZA 1AN1I 2ARPF 2NU1I 1CT4I 2SGQI 2SGDI 2OVOA 1KMAA 1M8CA 1LR8A 1YTPA 1TBRR 1TBQR 2SGFI 1OMTA 1IW4A 2N71A 1HDLA 1CT0I 2JXDA 2SGPI 2KCXA 1OMUA 2F3CI 1DS3I 1TURA 1CSOI 5JHWC 1LR9A 1TUSA 1OVOA 1CHOI 2KMQA 4HGUA 2LEOA 4GI3C 4OVOA 1Y1CA 3SEKC 2V53A 2GKVA 3B4VC 2NU0I 1UVGA 1YU6C 2GKTI 3QTLD 1SGPI 2QQCA 1CGJI 2N17A 1CGII 1CT2I 1TIHA 1SGYI 2KMOA 2WCYA 3TJQA 1IY6A 4SGBI 1HJAI 2NU2I 2GKRI 1R0RI 1Z7KB 1CE3A 1SGRI 2B0UC 2NU4I 3HH2C 1BUSA 1OYVI 1NUBA 1DS2I 2P6AC 1BMOA 2N52A 3SGQI 1LR7A 1HPTA 2QQDA 2SGEI 2ERWA 1MT1A 5DAEA 3SGBI 2M5XA 2JYYA 1UVFA 1SGQI 2JZMA 1TGSI
chains in the Genus database with same CATH superfamily
5J8FA 3CXLA 2X3TA 4E1PA 3KY9A 3R5DA 2QQ0A 2NU3I 1FARA 1K7VA 1FYBA 2GIVA 1PPFI 2WVJA 1V1IA 2KMRA 1XBTA 2XRCA 2B8TA 1S20A 1ULNA 2BUSA 3OVOA 3UEYA 2ROWA 1VDDA 2KMPA 2QQEA 2VRWB 1SGNI 5EX3A 3TOAA 1FAQA 1M8BA 2X52A 1PJUA 1PCEA 1SGDI 4UXJA 1SGEI 1UUCA 1Y1BA 1WTJA 1MJ9A 2DB6A 2PQ8A 1N13A 1IY5A 1H0ZA 1AN1I 2OD1A 2ARPF 2K9HA 2NU1I 2CWHA 1CT4I 2LUYA 3QWPA 3VDPA 2SGQI 2SGDI 2OVOA 1KMAA 1M8CA 1KBFA 1LR8A 5FUVA 5FUYA 4DNCA 1Z2IA 4UXIA 1YTPA 1TBRR 1TBQR 3TO6A 5CCMA 3TO7A 2SGFI 1OMTA 2CWFA 5CCLA 4L9MA 1IW4A 2N71A 2ENNA 1HDLA 1HEVA 2RC4A 1CT0I 9WGAA 3UGDA 1UHAA 2JXDA 1Q9BA 2KCXA 2SGPI 1RFHA 1OMUA 1XX6A 2F3CI 2RIJA 1DS3I 1TURA 1CSOI 2CWGA 2UVOA 3OXLA 5JHWC 1FY7A 1TBOA 7WGAA 5E3QA 1W4RA 2N1AB 2ENZA 3UFFA 3MEKA 1LR9A 1TUSA 4B6DA 2ELIA 2J87A 2JA1A 3FC3A 1P9ZA 5EX0A 1PTQA 2L7XA 1ULKA 2QPOA 1OVOA 2J9RA 1CHOI 1ULMA 3R5BA 1X74A 4MPIA 3VE5A 5HQ8A 2KMQA 3OL0A 1V1HA 3VDUA 4HGUA 3RU0A 2OU2A 3PDNA 2LEOA 4GI3C 4UXHA 4OVOA 5FUWA 1Y1CA 3SEKC 2JW6A 4FKDA 3FSYA 3BJIA 2V53A 2WGCA 2YQPA 2CJSC 2GKVA 3B4VC 3R5CA 2NU0I 2W0TA 5J8CA 1UVGA 1YU6C 3D00A 1W3SA 5HI7A 1MJBA 1XA6A 5E3RA 2GKTI 2YUUA 4E1RA 3QTLD 4AMLA 2E73A 1SGPI 2LB7A 2ORVA 2UZ3A 3UEJA 3E2IA 2QQCA 1CGJI 1CGII 2N17A 1CT2I 1TIHA 1SGYI 2KMOA 2WCYA 4JCVE 3TJQA 1IY6A 1TOTA 4SGBI 1HJAI 2NU2I 1WGTA 2GKRI 3OXGA 1R0RI 1Z7KB 2A20A 1CE3A 2ODDA 1P9GA 1SGRI 2B0UC 1NXUA 2NU4I 2DIPA 1R79A 3HH2C 3FSXA 3UGIA 1BUSA 1OYVI 2V1CC 1NUBA 1DS2I 2E5RA 5E3PA 1U5KA 2P6AC 2OZUA 1BMOA 2N52A 1MJAA 3OXFA 3SGQI 3UGLA 1LR7A 3UOEA 1HPTA 2QQDA 1WGCA 2SGEI 1PTRA 2DKVA 2L8EA 1K7TA 2Y0MA 2ERWA 3R5AA 4A24A 1MT1A 5DAEA 2V1CA 1X4SA 3GOXA 3SGBI 3QAHA 3TOBA 1K7UA 2M5XA 1WKXA 2JYYA 1UVFA 1SGQI 2ORWA 4WP4A 2JZMA 5FUXA 1KBEA 3E59A 1Y8FA 1TGSI 2GVIA 3TO9A 1TBNA 2FNFX
chains in the Genus database with same CATH topology
3CXLA 4E1PA 3KY9A 2QQ0A 2NU3I 1FARA 1FYBA 1PPFI 2WVJA 1V1IA 2KMRA 1XBTA 2XRCA 2B8TA 2BUSA 3OVOA 3UEYA 2ROWA 1VDDA 2KMPA 2QQEA 2VRWB 1SGNI 5EX3A 1FAQA 1M8BA 1PJUA 1PCEA 1SGDI 4UXJA 1SGEI 1Y1BA 1UUCA 2DB6A 1N13A 1IY5A 1H0ZA 1AN1I 2OD1A 2ARPF 2K9HA 2NU1I 1CT4I 2LUYA 3QWPA 3VDPA 2SGQI 2SGDI 2OVOA 1KMAA 1M8CA 1KBFA 1LR8A 5FUVA 5FUYA 4UXIA 1YTPA 1TBRR 1TBQR 5CCMA 2SGFI 1OMTA 5CCLA 1IW4A 4L9MA 2N71A 2ENNA 1HDLA 1CT0I 3UGDA 2JXDA 2SGPI 2KCXA 1RFHA 1OMUA 1XX6A 2F3CI 1DS3I 1TURA 1CSOI 5JHWC 3OXLA 1TBOA 1W4RA 2N1AB 2ENZA 3UFFA 3MEKA 1LR9A 1TUSA 4B6DA 2ELIA 2J87A 2JA1A 3FC3A 5EX0A 1PTQA 2L7XA 2QPOA 1OVOA 2J9RA 1CHOI 3VE5A 1X74A 5HQ8A 2KMQA 3OL0A 1V1HA 3VDUA 4HGUA 3RU0A 3PDNA 2LEOA 4GI3C 4UXHA 4OVOA 5FUWA 1Y1CA 3SEKC 2JW6A 4FKDA 3BJIA 2V53A 2YQPA 2CJSC 2GKVA 3B4VC 2NU0I 2W0TA 1UVGA 1YU6C 3D00A 1W3SA 5HI7A 1XA6A 2GKTI 2YUUA 4E1RA 3QTLD 2E73A 1SGPI 2ORVA 2UZ3A 3UEJA 3E2IA 2QQCA 1CGJI 1CGII 2N17A 1CT2I 1TIHA 1SGYI 2KMOA 2WCYA 4JCVE 3TJQA 1IY6A 1TOTA 4SGBI 1HJAI 2NU2I 2GKRI 3OXGA 1R0RI 1Z7KB 2A20A 1CE3A 2ODDA 1SGRI 2B0UC 2NU4I 2DIPA 1R79A 3HH2C 3UGIA 1BUSA 1OYVI 2V1CC 1NUBA 1DS2I 2E5RA 1U5KA 2P6AC 1BMOA 2N52A 3OXFA 3SGQI 3UGLA 1LR7A 1HPTA 2QQDA 2SGEI 1PTRA 2L8EA 2ERWA 4A24A 1MT1A 5DAEA 2V1CA 1X4SA 3GOXA 3SGBI 2M5XA 2JYYA 1UVFA 1SGQI 2ORWA 2JZMA 5FUXA 1KBEA 3E59A 1Y8FA 1TGSI 2GVIA 1TBNA 2FNFX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NU3 I;  1FYB A;  1PPF I;  2KMR A;  2XRC A;  2BUS A;  3OVO A;  2KMP A;  1SGN I;  1M8B A;  1PJU A;  1PCE A;  1SGD I;  1SGE I;  1UUC A;  1Y1B A;  1N13 A;  1IY5 A;  1H0Z A;  1AN1 I;  2ARP F;  2NU1 I;  1CT4 I;  2SGQ I;  2SGD I;  2OVO A;  1KMA A;  1M8C A;  1LR8 A;  1YTP A;  1TBR R;  1TBQ R;  2SGF I;  1OMT A;  1IW4 A;  2N71 A;  1HDL A;  1CT0 I;  2JXD A;  2SGP I;  2KCX A;  1OMU A;  2F3C I;  1DS3 I;  1TUR A;  1CSO I;  5JHW C;  1LR9 A;  1TUS A;  1OVO A;  1CHO I;  2KMQ A;  4HGU A;  2LEO A;  4GI3 C;  4OVO A;  1Y1C A;  3SEK C;  2V53 A;  2GKV A;  3B4V C;  2NU0 I;  1UVG A;  1YU6 C;  2GKT I;  3QTL D;  1SGP I;  2QQC A;  1CGJ I;  2N17 A;  1CGI I;  1CT2 I;  1TIH A;  1SGY I;  2KMO A;  2WCY A;  3TJQ A;  1IY6 A;  4SGB I;  1HJA I;  2NU2 I;  2GKR I;  1R0R I;  1Z7K B;  1CE3 A;  1SGR I;  2B0U C;  2NU4 I;  3HH2 C;  1BUS A;  1OYV I;  1NUB A;  1DS2 I;  2P6A C;  1BMO A;  2N52 A;  3SGQ I;  1LR7 A;  1HPT A;  2QQD A;  2SGE I;  2ERW A;  1MT1 A;  5DAE A;  3SGB I;  2M5X A;  2JYY A;  1UVF A;  1SGQ I;  2JZM A;  1TGS I; 
#chains in the Genus database with same CATH topology
 5J8F A;  3CXL A;  2X3T A;  4E1P A;  3KY9 A;  3R5D A;  2QQ0 A;  2NU3 I;  1FAR A;  1K7V A;  1FYB A;  2GIV A;  1PPF I;  2WVJ A;  1V1I A;  2KMR A;  1XBT A;  2XRC A;  2B8T A;  1S20 A;  1ULN A;  2BUS A;  3OVO A;  3UEY A;  2ROW A;  1VDD A;  2KMP A;  2QQE A;  2VRW B;  1SGN I;  5EX3 A;  3TOA A;  1FAQ A;  1M8B A;  2X52 A;  1PJU A;  1PCE A;  1SGD I;  4UXJ A;  1SGE I;  1UUC A;  1Y1B A;  1WTJ A;  1MJ9 A;  2DB6 A;  2PQ8 A;  1N13 A;  1IY5 A;  1H0Z A;  1AN1 I;  2OD1 A;  2ARP F;  2K9H A;  2NU1 I;  2CWH A;  1CT4 I;  2LUY A;  3QWP A;  3VDP A;  2SGQ I;  2SGD I;  2OVO A;  1KMA A;  1M8C A;  1KBF A;  1LR8 A;  5FUV A;  5FUY A;  4DNC A;  1Z2I A;  4UXI A;  1YTP A;  1TBR R;  1TBQ R;  3TO6 A;  5CCM A;  3TO7 A;  2SGF I;  1OMT A;  2CWF A;  5CCL A;  4L9M A;  1IW4 A;  2N71 A;  2ENN A;  1HDL A;  1HEV A;  2RC4 A;  1CT0 I;  9WGA A;  3UGD A;  1UHA A;  2JXD A;  1Q9B A;  2KCX A;  2SGP I;  1RFH A;  1OMU A;  1XX6 A;  2F3C I;  2RIJ A;  1DS3 I;  1TUR A;  1CSO I;  2CWG A;  2UVO A;  3OXL A;  5JHW C;  1FY7 A;  1TBO A;  7WGA A;  5E3Q A;  1W4R A;  2N1A B;  2ENZ A;  3UFF A;  3MEK A;  1LR9 A;  1TUS A;  4B6D A;  2ELI A;  2J87 A;  2JA1 A;  3FC3 A;  1P9Z A;  5EX0 A;  1PTQ A;  2L7X A;  1ULK A;  2QPO A;  1OVO A;  2J9R A;  1CHO I;  1ULM A;  3R5B A;  1X74 A;  4MPI A;  3VE5 A;  5HQ8 A;  2KMQ A;  3OL0 A;  1V1H A;  3VDU A;  4HGU A;  3RU0 A;  2OU2 A;  3PDN A;  2LEO A;  4GI3 C;  4UXH A;  4OVO A;  5FUW A;  1Y1C A;  3SEK C;  2JW6 A;  4FKD A;  3FSY A;  3BJI A;  2V53 A;  2WGC A;  2YQP A;  2CJS C;  2GKV A;  3B4V C;  3R5C A;  2NU0 I;  2W0T A;  5J8C A;  1UVG A;  1YU6 C;  3D00 A;  1W3S A;  5HI7 A;  1MJB A;  1XA6 A;  5E3R A;  2GKT I;  2YUU A;  4E1R A;  3QTL D;  4AML A;  2E73 A;  1SGP I;  2LB7 A;  2ORV A;  2UZ3 A;  3UEJ A;  3E2I A;  2QQC A;  1CGJ I;  1CGI I;  2N17 A;  1CT2 I;  1TIH A;  1SGY I;  2KMO A;  2WCY A;  4JCV E;  3TJQ A;  1IY6 A;  1TOT A;  4SGB I;  1HJA I;  2NU2 I;  1WGT A;  2GKR I;  3OXG A;  1R0R I;  1Z7K B;  2A20 A;  1CE3 A;  2ODD A;  1P9G A;  1SGR I;  2B0U C;  1NXU A;  2NU4 I;  2DIP A;  1R79 A;  3HH2 C;  3FSX A;  3UGI A;  1BUS A;  1OYV I;  2V1C C;  1NUB A;  1DS2 I;  2E5R A;  5E3P A;  1U5K A;  2P6A C;  2OZU A;  1BMO A;  2N52 A;  1MJA A;  3OXF A;  3SGQ I;  3UGL A;  1LR7 A;  3UOE A;  1HPT A;  2QQD A;  1WGC A;  2SGE I;  1PTR A;  2DKV A;  2L8E A;  1K7T A;  2Y0M A;  2ERW A;  3R5A A;  4A24 A;  1MT1 A;  5DAE A;  2V1C A;  1X4S A;  3GOX A;  3SGB I;  3QAH A;  3TOB A;  1K7U A;  2M5X A;  1WKX A;  2JYY A;  1UVF A;  1SGQ I;  2ORW A;  4WP4 A;  2JZM A;  5FUX A;  1KBE A;  3E59 A;  1Y8F A;  1TGS I;  2GVI A;  3TO9 A;  1TBN A;  2FNF X; 
#chains in the Genus database with same CATH homology
 3CXL A;  4E1P A;  3KY9 A;  2QQ0 A;  2NU3 I;  1FAR A;  1FYB A;  1PPF I;  2WVJ A;  1V1I A;  2KMR A;  1XBT A;  2XRC A;  2B8T A;  2BUS A;  3OVO A;  3UEY A;  2ROW A;  1VDD A;  2KMP A;  2QQE A;  2VRW B;  1SGN I;  5EX3 A;  1FAQ A;  1M8B A;  1PJU A;  1PCE A;  1SGD I;  4UXJ A;  1SGE I;  1Y1B A;  1UUC A;  2DB6 A;  1N13 A;  1IY5 A;  1H0Z A;  1AN1 I;  2OD1 A;  2ARP F;  2K9H A;  2NU1 I;  1CT4 I;  2LUY A;  3QWP A;  3VDP A;  2SGQ I;  2SGD I;  2OVO A;  1KMA A;  1M8C A;  1KBF A;  1LR8 A;  5FUV A;  5FUY A;  4UXI A;  1YTP A;  1TBR R;  1TBQ R;  5CCM A;  2SGF I;  1OMT A;  5CCL A;  1IW4 A;  4L9M A;  2N71 A;  2ENN A;  1HDL A;  1CT0 I;  3UGD A;  2JXD A;  2SGP I;  2KCX A;  1RFH A;  1OMU A;  1XX6 A;  2F3C I;  1DS3 I;  1TUR A;  1CSO I;  5JHW C;  3OXL A;  1TBO A;  1W4R A;  2N1A B;  2ENZ A;  3UFF A;  3MEK A;  1LR9 A;  1TUS A;  4B6D A;  2ELI A;  2J87 A;  2JA1 A;  3FC3 A;  5EX0 A;  1PTQ A;  2L7X A;  2QPO A;  1OVO A;  2J9R A;  1CHO I;  3VE5 A;  1X74 A;  5HQ8 A;  2KMQ A;  3OL0 A;  1V1H A;  3VDU A;  4HGU A;  3RU0 A;  3PDN A;  2LEO A;  4GI3 C;  4UXH A;  4OVO A;  5FUW A;  1Y1C A;  3SEK C;  2JW6 A;  4FKD A;  3BJI A;  2V53 A;  2YQP A;  2CJS C;  2GKV A;  3B4V C;  2NU0 I;  2W0T A;  1UVG A;  1YU6 C;  3D00 A;  1W3S A;  5HI7 A;  1XA6 A;  2GKT I;  2YUU A;  4E1R A;  3QTL D;  2E73 A;  1SGP I;  2ORV A;  2UZ3 A;  3UEJ A;  3E2I A;  2QQC A;  1CGJ I;  1CGI I;  2N17 A;  1CT2 I;  1TIH A;  1SGY I;  2KMO A;  2WCY A;  4JCV E;  3TJQ A;  1IY6 A;  1TOT A;  4SGB I;  1HJA I;  2NU2 I;  2GKR I;  3OXG A;  1R0R I;  1Z7K B;  2A20 A;  1CE3 A;  2ODD A;  1SGR I;  2B0U C;  2NU4 I;  2DIP A;  1R79 A;  3HH2 C;  3UGI A;  1BUS A;  1OYV I;  2V1C C;  1NUB A;  1DS2 I;  2E5R A;  1U5K A;  2P6A C;  1BMO A;  2N52 A;  3OXF A;  3SGQ I;  3UGL A;  1LR7 A;  1HPT A;  2QQD A;  2SGE I;  1PTR A;  2L8E A;  2ERW A;  4A24 A;  1MT1 A;  5DAE A;  2V1C A;  1X4S A;  3GOX A;  3SGB I;  2M5X A;  2JYY A;  1UVF A;  1SGQ I;  2ORW A;  2JZM A;  5FUX A;  1KBE A;  3E59 A;  1Y8F A;  1TGS I;  2GVI A;  1TBN A;  2FNF X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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