2KMPA

Solution structure of intermeidate iia of leeck-derived tryptase inhibitor, ldti.
Total Genus 6
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
6
sequence length
44
structure length
44
Chain Sequence
KKVCACPKILKPVCGSDGRTYANSCIARCNGVSIKSEGSCPTGI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Deciphering the structural basis that guides the oxidative folding of leech-derived tryptase inhibitor.
pubmed doi rcsb
molecule tags Hydrolase
source organism Hirudo medicinalis
molecule keywords Leech-derived tryptase inhibitor C
total genus 6
structure length 44
sequence length 44
ec nomenclature
pdb deposition date 2009-08-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00050 Kazal_1 Kazal-type serine protease inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 2kmpA00
2QQCA 1TURA 1CSOI 2NU2I 5DAEA 1NUBA 1M8CA 1BMOA 1TGSI 1SGPI 1DS3I 5JHWC 1LR7A 1DS2I 2KMPA 2KMQA 3QTLD 1CT4I 1HPTA 2JXDA 1Y1BA 1LR9A 3HH2C 2NU4I 1R0RI 2V53A 1AN1I 1KMAA 2ERWA 2SGQI 1YU6C 1LR8A 2P6AC 2GKVA 1MT1A 1IY6A 2BUSA 2SGPI 2SGDI 3B4VC 1N13A 2JYYA 1HJAI 1CT2I 1HDLA 1UVFA 1OMTA 2M5XA 2B0UC 1Z7KB 1H0ZA 1OMUA 1BUSA 2GKTI 2QQDA 2N71A 3SEKC 1PPFI 1OVOA 1UUCA 2XRCA 1TBRR 1YTPA 2WCYA 2NU3I 3OVOA 1CT0I 1M8BA 1SGQI 1CHOI 2N52A 1TIHA 4GI3C 4OVOA 2NU0I 3SGBI 1Y1CA 1TBQR 1CGJI 1SGDI 4SGBI 3SGQI 2F3CI 1PCEA 1IY5A 2KMOA 1SGNI 2JZMA 1FYBA 1SGYI 2KMRA 1SGEI 1PJUA 2SGFI 3TJQA 1CGII 1CE3A 1OYVI 2KCXA 2ARPF 2OVOA 2SGEI 2LEOA 2NU1I 1SGRI 4HGUA 1IW4A 2GKRI 2N17A 1UVGA 1TUSA
chains in the Genus database with same CATH superfamily
2QQCA 1TURA 2PQ8A 1KBFA 4AMLA 3TO9A 1CSOI 2NU2I 5DAEA 2YQPA 1NUBA 3UFFA 5HQ8A 1M8CA 1BMOA 1TGSI 1Y8FA 2X3TA 2ELIA 2OD1A 3TOAA 2QQEA 1SGPI 1MJBA 4E1RA 5FUXA 2L7XA 1DS3I 2FNFX 1K7VA 3OXGA 3TOBA 5JHWC 2JA1A 1LR7A 3VDUA 2DIPA 2RC4A 2X52A 2A20A 1DS2I 2KMPA 1TBNA 1WGCA 2KMQA 2CWFA 5E3RA 5EX3A 3QTLD 5EX0A 1CT4I 1HPTA 1X74A 1Y1BA 1LR9A 2JXDA 3FSXA 2NU4I 3HH2C 1R0RI 4MPIA 2V53A 2WGCA 1WGTA 3D00A 5E3QA 1FARA 1AN1I 1KBEA 5CCMA 1KMAA 2ERWA 2SGQI 1YU6C 2P6AC 2OZUA 2J87A 3BJIA 2GKVA 1ULNA 3R5CA 1MT1A 1IY6A 3E2IA 1MJ9A 5E3PA 2BUSA 2SGPI 3RU0A 2SGDI 3B4VC 1N13A 1Q9BA 2L8EA 3R5DA 7WGAA 1WKXA 1TOTA 3E59A 2JYYA 4FKDA 2LB7A 4JCVE 2ROWA 1HJAI 3TO7A 3UOEA 2CWGA 5J8CA 1CT2I 3R5BA 1HDLA 3VE5A 1UVFA 1OMTA 2M5XA 2B0UC 2N17A 1Z7KB 1H0ZA 1OMUA 1BUSA 3CXLA 1ULMA 2ORWA 5HI7A 2GKTI 2RIJA 2QQDA 2N71A 3UGDA 2DKVA 3SEKC 1PPFI 1WTJA 1OVOA 1UUCA 2XRCA 9WGAA 1TBRR 1VDDA 3TO6A 1FAQA 1V1IA 1YTPA 2WCYA 4B6DA 2NU3I 3OXLA 3OVOA 5FUVA 2UVOA 4A24A 2N1AB 1CT0I 5J8FA 1M8BA 1SGQI 4UXIA 1CHOI 4L9MA 2N52A 1TIHA 1TBOA 2W0TA 2ODDA 4GI3C 1FY7A 4OVOA 4WP4A 3UGLA 2NU0I 3R5AA 2V1CA 2JW6A 3SGBI 3QAHA 5FUWA 1Y1CA 1TBQR 1CGJI 1SGDI 2VRWB 4SGBI 2J9RA 3SGQI 3UEYA 2F3CI 1PCEA 1IY5A 2LUYA 2K9HA 2KMOA 2QQ0A 1NXUA 2UZ3A 5FUYA 3VDPA 1SGNI 2JZMA 1Z2IA 5CCLA 2OU2A 1XX6A 1FYBA 3MEKA 1K7UA 1SGYI 1X4SA 1ULKA 2KMRA 2ENZA 1SGEI 1V1HA 1MJAA 1UHAA 3OXFA 1W4RA 2V1CC 4DNCA 2E5RA 2WVJA 3QWPA 3GOXA 1P9GA 1PJUA 1U5KA 3FC3A 2SGFI 3UEJA 3TJQA 1CGII 4E1PA 2B8TA 1CE3A 1HEVA 1OYVI 2QPOA 2KCXA 2Y0MA 2ARPF 1PTQA 2GVIA 1R79A 2ORVA 1XA6A 2OVOA 1K7TA 2DB6A 4UXJA 1RFHA 1XBTA 2SGEI 2CJSC 2YUUA 2LEOA 2NU1I 3FSYA 1P9ZA 4UXHA 2ENNA 1SGRI 3OL0A 4HGUA 1IW4A 2E73A 1PTRA 3UGIA 2CWHA 1S20A 1W3SA 2GKRI 2GIVA 1LR8A 1UVGA 1TUSA 3KY9A 3PDNA
chains in the Genus database with same CATH topology
2QQCA 1TURA 1KBFA 1CSOI 2NU2I 5DAEA 2YQPA 1NUBA 3UFFA 5HQ8A 1M8CA 1BMOA 1TGSI 1Y8FA 2ELIA 2OD1A 2QQEA 1SGPI 4E1RA 5FUXA 2L7XA 1DS3I 2FNFX 5JHWC 3OXGA 2JA1A 1LR7A 3VDUA 2DIPA 2A20A 1DS2I 2KMPA 1TBNA 2KMQA 5EX3A 5EX0A 3QTLD 1CT4I 1HPTA 1X74A 1Y1BA 1LR9A 2JXDA 3HH2C 2NU4I 1R0RI 2V53A 3D00A 1FARA 1AN1I 1KBEA 5CCMA 1KMAA 2ERWA 2SGQI 1YU6C 2P6AC 2J87A 3BJIA 2GKVA 1MT1A 1IY6A 3E2IA 2BUSA 2SGPI 3RU0A 2SGDI 3B4VC 1N13A 2L8EA 1TOTA 3E59A 2JYYA 4FKDA 4JCVE 2ROWA 1HJAI 1CT2I 1HDLA 3VE5A 1UVFA 1OMTA 2M5XA 2B0UC 2N17A 1Z7KB 1H0ZA 1OMUA 1BUSA 3CXLA 5HI7A 2ORWA 2GKTI 2QQDA 2N71A 3UGDA 3SEKC 1PPFI 1OVOA 1UUCA 2XRCA 1TBRR 1VDDA 1FAQA 1V1IA 1YTPA 2WCYA 4B6DA 2NU3I 3OXLA 3OVOA 5FUVA 4A24A 2N1AB 1CT0I 1M8BA 1SGQI 4UXIA 1CHOI 4L9MA 2N52A 1TIHA 1TBOA 2W0TA 2ODDA 4GI3C 4OVOA 3UGLA 2NU0I 2V1CA 2JW6A 3SGBI 5FUWA 1Y1CA 1TBQR 1CGJI 1SGDI 2VRWB 4SGBI 2J9RA 3SGQI 3UEYA 2F3CI 1PCEA 1IY5A 2LUYA 2K9HA 2KMOA 2QQ0A 2UZ3A 5FUYA 3VDPA 1SGNI 2JZMA 5CCLA 1XX6A 1FYBA 3MEKA 1SGYI 1X4SA 2KMRA 2ENZA 1SGEI 1V1HA 3OXFA 1W4RA 2V1CC 2E5RA 2WVJA 3QWPA 3GOXA 1PJUA 1U5KA 3FC3A 2SGFI 3UEJA 3TJQA 1CGII 4E1PA 2B8TA 1CE3A 1OYVI 2QPOA 2KCXA 2ARPF 1PTQA 2GVIA 1R79A 2ORVA 1XA6A 2OVOA 4UXJA 2DB6A 1RFHA 1XBTA 2SGEI 2CJSC 2YUUA 2LEOA 2NU1I 4UXHA 2ENNA 1SGRI 3OL0A 4HGUA 1IW4A 2E73A 1PTRA 3UGIA 2GKRI 1W3SA 1LR8A 1UVGA 1TUSA 3KY9A 3PDNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QQC A;  1TUR A;  1CSO I;  2NU2 I;  5DAE A;  1NUB A;  1M8C A;  1BMO A;  1TGS I;  1SGP I;  1DS3 I;  5JHW C;  1LR7 A;  1DS2 I;  2KMP A;  2KMQ A;  3QTL D;  1CT4 I;  1HPT A;  2JXD A;  1Y1B A;  1LR9 A;  3HH2 C;  2NU4 I;  1R0R I;  2V53 A;  1AN1 I;  1KMA A;  2ERW A;  2SGQ I;  1YU6 C;  1LR8 A;  2P6A C;  2GKV A;  1MT1 A;  1IY6 A;  2BUS A;  2SGP I;  2SGD I;  3B4V C;  1N13 A;  2JYY A;  1HJA I;  1CT2 I;  1HDL A;  1UVF A;  1OMT A;  2M5X A;  2B0U C;  1Z7K B;  1H0Z A;  1OMU A;  1BUS A;  2GKT I;  2QQD A;  2N71 A;  3SEK C;  1PPF I;  1OVO A;  1UUC A;  2XRC A;  1TBR R;  1YTP A;  2WCY A;  2NU3 I;  3OVO A;  1CT0 I;  1M8B A;  1SGQ I;  1CHO I;  2N52 A;  1TIH A;  4GI3 C;  4OVO A;  2NU0 I;  3SGB I;  1Y1C A;  1TBQ R;  1CGJ I;  1SGD I;  4SGB I;  3SGQ I;  2F3C I;  1PCE A;  1IY5 A;  2KMO A;  1SGN I;  2JZM A;  1FYB A;  1SGY I;  2KMR A;  1SGE I;  1PJU A;  2SGF I;  3TJQ A;  1CGI I;  1CE3 A;  1OYV I;  2KCX A;  2ARP F;  2OVO A;  2SGE I;  2LEO A;  2NU1 I;  1SGR I;  4HGU A;  1IW4 A;  2GKR I;  2N17 A;  1UVG A;  1TUS A; 
#chains in the Genus database with same CATH topology
 2QQC A;  1TUR A;  2PQ8 A;  1KBF A;  4AML A;  3TO9 A;  1CSO I;  2NU2 I;  5DAE A;  2YQP A;  1NUB A;  3UFF A;  5HQ8 A;  1M8C A;  1BMO A;  1TGS I;  1Y8F A;  2X3T A;  2ELI A;  2OD1 A;  3TOA A;  2QQE A;  1SGP I;  1MJB A;  4E1R A;  5FUX A;  2L7X A;  1DS3 I;  2FNF X;  1K7V A;  3OXG A;  3TOB A;  5JHW C;  2JA1 A;  1LR7 A;  3VDU A;  2DIP A;  2RC4 A;  2X52 A;  2A20 A;  1DS2 I;  2KMP A;  1TBN A;  1WGC A;  2KMQ A;  2CWF A;  5E3R A;  5EX3 A;  3QTL D;  5EX0 A;  1CT4 I;  1HPT A;  1X74 A;  1Y1B A;  1LR9 A;  2JXD A;  3FSX A;  2NU4 I;  3HH2 C;  1R0R I;  4MPI A;  2V53 A;  2WGC A;  1WGT A;  3D00 A;  5E3Q A;  1FAR A;  1AN1 I;  1KBE A;  5CCM A;  1KMA A;  2ERW A;  2SGQ I;  1YU6 C;  2P6A C;  2OZU A;  2J87 A;  3BJI A;  2GKV A;  1ULN A;  3R5C A;  1MT1 A;  1IY6 A;  3E2I A;  1MJ9 A;  5E3P A;  2BUS A;  2SGP I;  3RU0 A;  2SGD I;  3B4V C;  1N13 A;  1Q9B A;  2L8E A;  3R5D A;  7WGA A;  1WKX A;  1TOT A;  3E59 A;  2JYY A;  4FKD A;  2LB7 A;  4JCV E;  2ROW A;  1HJA I;  3TO7 A;  3UOE A;  2CWG A;  5J8C A;  1CT2 I;  3R5B A;  1HDL A;  3VE5 A;  1UVF A;  1OMT A;  2M5X A;  2B0U C;  2N17 A;  1Z7K B;  1H0Z A;  1OMU A;  1BUS A;  3CXL A;  1ULM A;  2ORW A;  5HI7 A;  2GKT I;  2RIJ A;  2QQD A;  2N71 A;  3UGD A;  2DKV A;  3SEK C;  1PPF I;  1WTJ A;  1OVO A;  1UUC A;  2XRC A;  9WGA A;  1TBR R;  1VDD A;  3TO6 A;  1FAQ A;  1V1I A;  1YTP A;  2WCY A;  4B6D A;  2NU3 I;  3OXL A;  3OVO A;  5FUV A;  2UVO A;  4A24 A;  2N1A B;  1CT0 I;  5J8F A;  1M8B A;  1SGQ I;  4UXI A;  1CHO I;  4L9M A;  2N52 A;  1TIH A;  1TBO A;  2W0T A;  2ODD A;  4GI3 C;  1FY7 A;  4OVO A;  4WP4 A;  3UGL A;  2NU0 I;  3R5A A;  2V1C A;  2JW6 A;  3SGB I;  3QAH A;  5FUW A;  1Y1C A;  1TBQ R;  1CGJ I;  1SGD I;  2VRW B;  4SGB I;  2J9R A;  3SGQ I;  3UEY A;  2F3C I;  1PCE A;  1IY5 A;  2LUY A;  2K9H A;  2KMO A;  2QQ0 A;  1NXU A;  2UZ3 A;  5FUY A;  3VDP A;  1SGN I;  2JZM A;  1Z2I A;  5CCL A;  2OU2 A;  1XX6 A;  1FYB A;  3MEK A;  1K7U A;  1SGY I;  1X4S A;  1ULK A;  2KMR A;  2ENZ A;  1SGE I;  1V1H A;  1MJA A;  1UHA A;  3OXF A;  1W4R A;  2V1C C;  4DNC A;  2E5R A;  2WVJ A;  3QWP A;  3GOX A;  1P9G A;  1PJU A;  1U5K A;  3FC3 A;  2SGF I;  3UEJ A;  3TJQ A;  1CGI I;  4E1P A;  2B8T A;  1CE3 A;  1HEV A;  1OYV I;  2QPO A;  2KCX A;  2Y0M A;  2ARP F;  1PTQ A;  2GVI A;  1R79 A;  2ORV A;  1XA6 A;  2OVO A;  1K7T A;  2DB6 A;  4UXJ A;  1RFH A;  1XBT A;  2SGE I;  2CJS C;  2YUU A;  2LEO A;  2NU1 I;  3FSY A;  1P9Z A;  4UXH A;  2ENN A;  1SGR I;  3OL0 A;  4HGU A;  1IW4 A;  2E73 A;  1PTR A;  3UGI A;  2CWH A;  1S20 A;  1W3S A;  2GKR I;  2GIV A;  1LR8 A;  1UVG A;  1TUS A;  3KY9 A;  3PDN A; 
#chains in the Genus database with same CATH homology
 2QQC A;  1TUR A;  1KBF A;  1CSO I;  2NU2 I;  5DAE A;  2YQP A;  1NUB A;  3UFF A;  5HQ8 A;  1M8C A;  1BMO A;  1TGS I;  1Y8F A;  2ELI A;  2OD1 A;  2QQE A;  1SGP I;  4E1R A;  5FUX A;  2L7X A;  1DS3 I;  2FNF X;  5JHW C;  3OXG A;  2JA1 A;  1LR7 A;  3VDU A;  2DIP A;  2A20 A;  1DS2 I;  2KMP A;  1TBN A;  2KMQ A;  5EX3 A;  5EX0 A;  3QTL D;  1CT4 I;  1HPT A;  1X74 A;  1Y1B A;  1LR9 A;  2JXD A;  3HH2 C;  2NU4 I;  1R0R I;  2V53 A;  3D00 A;  1FAR A;  1AN1 I;  1KBE A;  5CCM A;  1KMA A;  2ERW A;  2SGQ I;  1YU6 C;  2P6A C;  2J87 A;  3BJI A;  2GKV A;  1MT1 A;  1IY6 A;  3E2I A;  2BUS A;  2SGP I;  3RU0 A;  2SGD I;  3B4V C;  1N13 A;  2L8E A;  1TOT A;  3E59 A;  2JYY A;  4FKD A;  4JCV E;  2ROW A;  1HJA I;  1CT2 I;  1HDL A;  3VE5 A;  1UVF A;  1OMT A;  2M5X A;  2B0U C;  2N17 A;  1Z7K B;  1H0Z A;  1OMU A;  1BUS A;  3CXL A;  5HI7 A;  2ORW A;  2GKT I;  2QQD A;  2N71 A;  3UGD A;  3SEK C;  1PPF I;  1OVO A;  1UUC A;  2XRC A;  1TBR R;  1VDD A;  1FAQ A;  1V1I A;  1YTP A;  2WCY A;  4B6D A;  2NU3 I;  3OXL A;  3OVO A;  5FUV A;  4A24 A;  2N1A B;  1CT0 I;  1M8B A;  1SGQ I;  4UXI A;  1CHO I;  4L9M A;  2N52 A;  1TIH A;  1TBO A;  2W0T A;  2ODD A;  4GI3 C;  4OVO A;  3UGL A;  2NU0 I;  2V1C A;  2JW6 A;  3SGB I;  5FUW A;  1Y1C A;  1TBQ R;  1CGJ I;  1SGD I;  2VRW B;  4SGB I;  2J9R A;  3SGQ I;  3UEY A;  2F3C I;  1PCE A;  1IY5 A;  2LUY A;  2K9H A;  2KMO A;  2QQ0 A;  2UZ3 A;  5FUY A;  3VDP A;  1SGN I;  2JZM A;  5CCL A;  1XX6 A;  1FYB A;  3MEK A;  1SGY I;  1X4S A;  2KMR A;  2ENZ A;  1SGE I;  1V1H A;  3OXF A;  1W4R A;  2V1C C;  2E5R A;  2WVJ A;  3QWP A;  3GOX A;  1PJU A;  1U5K A;  3FC3 A;  2SGF I;  3UEJ A;  3TJQ A;  1CGI I;  4E1P A;  2B8T A;  1CE3 A;  1OYV I;  2QPO A;  2KCX A;  2ARP F;  1PTQ A;  2GVI A;  1R79 A;  2ORV A;  1XA6 A;  2OVO A;  4UXJ A;  2DB6 A;  1RFH A;  1XBT A;  2SGE I;  2CJS C;  2YUU A;  2LEO A;  2NU1 I;  4UXH A;  2ENN A;  1SGR I;  3OL0 A;  4HGU A;  1IW4 A;  2E73 A;  1PTR A;  3UGI A;  2GKR I;  1W3S A;  1LR8 A;  1UVG A;  1TUS A;  3KY9 A;  3PDN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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