2KMQA

Solution structure of intermediate iib of leech-derived tryptase inhibitor, ldti.
Total Genus 5
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
5
sequence length
44
structure length
44
Chain Sequence
KKVCACPKILKPVCGSDGRTYANSCIARCNGVSIKSEGSCPTGI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Hirudo medicinalis
publication title Deciphering the structural basis that guides the oxidative folding of leech-derived tryptase inhibitor.
pubmed doi rcsb
molecule keywords Leech-derived tryptase inhibitor C
total genus 5
structure length 44
sequence length 44
ec nomenclature
pdb deposition date 2009-08-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00050 Kazal_1 Kazal-type serine protease inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 2kmqA00
2SGEI 1CT2I 1OYVI 1MT1A 1KMAA 1OMUA 2N71A 2WCYA 1SGNI 2SGDI 1LR9A 1FYBA 1TGSI 1CT0I 1PCEA 2GKTI 1IY6A 1HPTA 2M5XA 2JXDA 2JZMA 2N17A 1UUCA 1TIHA 2NU4I 1YU6C 4GI3C 5DAEA 1OVOA 1TBQR 1CGJI 1CE3A 2BUSA 1IW4A 2QQCA 3SGBI 2NU2I 1PJUA 1LR7A 1CT4I 2LEOA 1UVFA 4SGBI 1SGRI 1Y1BA 1IY5A 2NU3I 2B0UC 1SGEI 1HDLA 1LR8A 1UVGA 2KMQA 2KMOA 3HH2C 1TURA 2ERWA 3SGQI 3TJQA 3SEKC 2SGQI 1M8CA 1N13A 2SGPI 1H0ZA 1R0RI 1BUSA 1M8BA 2SGFI 2P6AC 2KMRA 1DS3I 1SGQI 1CHOI 1NUBA 1TUSA 1PPFI 5JHWC 1SGPI 2JYYA 1YTPA 2F3CI 3QTLD 1TBRR 1SGDI 2NU0I 2ARPF 2XRCA 1CGII 1CSOI 1Z7KB 2KMPA 1DS2I 1AN1I 1Y1CA 1SGYI 3OVOA 2KCXA 3B4VC 2GKVA 1HJAI 4HGUA 4OVOA 2N52A 2V53A 2QQDA 1OMTA 1BMOA 2GKRI 2OVOA 2NU1I
chains in the Genus database with same CATH superfamily
2PQ8A 2SGEI 1CT2I 1OYVI 1MT1A 4UXJA 5CCMA 2ORVA 2QPOA 5EX0A 1KMAA 1OMUA 2N71A 2WCYA 5FUWA 1P9GA 3QWPA 1SGNI 2SGDI 2J87A 1LR9A 2K9HA 1S20A 1FYBA 2E73A 3FSYA 1TGSI 1CT0I 2ORWA 2RIJA 1PCEA 2J9RA 2GKTI 1V1IA 1IY6A 5E3QA 1HPTA 2M5XA 4UXIA 2JXDA 1ULMA 3TOAA 2JZMA 2L7XA 3UGLA 4UXHA 2N17A 3MEKA 1UUCA 5HQ8A 1W3SA 1TIHA 2QQEA 1WGCA 4L9MA 2CWHA 1YU6C 2NU4I 2CWFA 1R79A 4GI3C 4JCVE 2QQ0A 1OVOA 5DAEA 1TBQR 1CGJI 3UEYA 4AMLA 1CE3A 2BUSA 1IW4A 4E1RA 2QQCA 3SGBI 2NU2I 1PJUA 1ULKA 2CWGA 2UZ3A 1LR7A 1CT4I 4FKDA 3TOBA 5HI7A 2LEOA 3UGIA 1UVFA 4E1PA 1NXUA 4SGBI 3UEJA 2UVOA 3OXGA 2V1CC 3E59A 2ENNA 1SGRI 1Q9BA 1Y1BA 1MJ9A 5E3RA 1PTRA 1IY5A 1U5KA 2NU3I 1MJAA 2Y0MA 2B0UC 4B6DA 2X52A 3VE5A 2YQPA 1SGEI 3RU0A 1HEVA 1HDLA 1FARA 1LR8A 2JA1A 5E3PA 1UVGA 1WGTA 1V1HA 2KMQA 5FUYA 3R5BA 1K7UA 2KMOA 3HH2C 3UGDA 3OXFA 1XX6A 4DNCA 3FSXA 9WGAA 1TURA 2ERWA 2DKVA 1VDDA 3SGQI 3PDNA 3TJQA 3SEKC 1RFHA 2WVJA 2SGQI 1Z2IA 1M8CA 1N13A 1X74A 5CCLA 2SGPI 3FC3A 3KY9A 1H0ZA 1R0RI 1BUSA 1Y8FA 1FAQA 1M8BA 4A24A 3QAHA 3D00A 5J8FA 2SGFI 1XBTA 2P6AC 3TO7A 2V1CA 2RC4A 2KMRA 1TBNA 1DS3I 1SGQI 2X3TA 2YUUA 1CHOI 3BJIA 2FNFX 4WP4A 1TBOA 1NUBA 1TUSA 2OD1A 1PPFI 5JHWC 3GOXA 1K7TA 3TO9A 3UFFA 1ULNA 1SGPI 2JYYA 1WKXA 1YTPA 2F3CI 1TOTA 1TBRR 2CJSC 1SGDI 3QTLD 4MPIA 2NU0I 1K7VA 3CXLA 2ARPF 1MJBA 1UHAA 1KBFA 5EX3A 2XRCA 3OL0A 1CGII 2DB6A 1CSOI 5FUVA 1WTJA 1Z7KB 3R5DA 2ELIA 2KMPA 2LUYA 2ODDA 1DS2I 1AN1I 1Y1CA 5J8CA 1SGYI 3TO6A 3OVOA 2ROWA 2LB7A 2KCXA 3R5CA 2OU2A 2VRWB 3B4VC 2W0TA 2GKVA 2A20A 3E2IA 2B8TA 1HJAI 1PTQA 2ENZA 2WGCA 3VDUA 2DIPA 1XA6A 4HGUA 7WGAA 4OVOA 2JW6A 2N52A 1X4SA 1FY7A 2E5RA 1KBEA 2N1AB 2OZUA 3OXLA 2V53A 1P9ZA 2QQDA 3UOEA 1OMTA 2GIVA 1W4RA 1BMOA 2L8EA 2GKRI 3VDPA 2OVOA 2GVIA 2NU1I 3R5AA 5FUXA
chains in the Genus database with same CATH topology
2SGEI 1CT2I 1OYVI 1MT1A 4UXJA 5CCMA 2ORVA 2QPOA 5EX0A 1KMAA 1OMUA 2N71A 2WCYA 5FUWA 3QWPA 1SGNI 2SGDI 2J87A 1LR9A 2K9HA 1FYBA 2E73A 1TGSI 1CT0I 2ORWA 1PCEA 2J9RA 2GKTI 1V1IA 1IY6A 1HPTA 2M5XA 4UXIA 2JXDA 2JZMA 2L7XA 3UGLA 4UXHA 2N17A 3MEKA 1UUCA 5HQ8A 1W3SA 1TIHA 2QQEA 4L9MA 2NU4I 1YU6C 1R79A 4GI3C 4JCVE 2QQ0A 1OVOA 5DAEA 1TBQR 1CGJI 3UEYA 1CE3A 2BUSA 1IW4A 4E1RA 2QQCA 3SGBI 2NU2I 1PJUA 2UZ3A 1LR7A 1CT4I 4FKDA 3UGIA 5HI7A 2LEOA 4E1PA 1UVFA 4SGBI 3UEJA 3OXGA 2V1CC 3E59A 2ENNA 1SGRI 1Y1BA 1IY5A 1PTRA 1U5KA 2NU3I 2B0UC 4B6DA 3VE5A 2YQPA 1SGEI 3RU0A 1HDLA 1FARA 1LR8A 2JA1A 1UVGA 1V1HA 2KMQA 5FUYA 2KMOA 3HH2C 3UGDA 3OXFA 1XX6A 1TURA 2ERWA 1VDDA 3SGQI 3PDNA 3TJQA 3SEKC 1RFHA 2WVJA 2SGQI 1M8CA 1N13A 1X74A 5CCLA 2SGPI 3FC3A 3KY9A 1H0ZA 1R0RI 1BUSA 1Y8FA 1FAQA 1M8BA 4A24A 3D00A 2SGFI 1XBTA 2P6AC 2V1CA 2KMRA 1TBNA 1DS3I 1SGQI 2YUUA 1CHOI 3BJIA 2FNFX 1TBOA 1NUBA 1TUSA 2OD1A 1PPFI 5JHWC 3GOXA 3UFFA 1SGPI 2JYYA 1YTPA 2F3CI 1TOTA 1TBRR 2CJSC 1SGDI 3QTLD 2NU0I 3CXLA 2ARPF 1KBFA 5EX3A 2XRCA 3OL0A 1CGII 2DB6A 1CSOI 5FUVA 1Z7KB 2ELIA 2KMPA 2LUYA 2ODDA 1DS2I 1AN1I 1Y1CA 1SGYI 3OVOA 2ROWA 2KCXA 2VRWB 3B4VC 2W0TA 2GKVA 2A20A 3E2IA 2B8TA 1HJAI 1PTQA 2ENZA 3VDUA 2DIPA 1XA6A 4HGUA 4OVOA 2JW6A 2N52A 1X4SA 2E5RA 1KBEA 2N1AB 3OXLA 2V53A 2QQDA 1OMTA 1W4RA 1BMOA 2L8EA 2GKRI 3VDPA 2OVOA 2GVIA 2NU1I 5FUXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2SGE I;  1CT2 I;  1OYV I;  1MT1 A;  1KMA A;  1OMU A;  2N71 A;  2WCY A;  1SGN I;  2SGD I;  1LR9 A;  1FYB A;  1TGS I;  1CT0 I;  1PCE A;  2GKT I;  1IY6 A;  1HPT A;  2M5X A;  2JXD A;  2JZM A;  2N17 A;  1UUC A;  1TIH A;  2NU4 I;  1YU6 C;  4GI3 C;  5DAE A;  1OVO A;  1TBQ R;  1CGJ I;  1CE3 A;  2BUS A;  1IW4 A;  2QQC A;  3SGB I;  2NU2 I;  1PJU A;  1LR7 A;  1CT4 I;  2LEO A;  1UVF A;  4SGB I;  1SGR I;  1Y1B A;  1IY5 A;  2NU3 I;  2B0U C;  1SGE I;  1HDL A;  1LR8 A;  1UVG A;  2KMQ A;  2KMO A;  3HH2 C;  1TUR A;  2ERW A;  3SGQ I;  3TJQ A;  3SEK C;  2SGQ I;  1M8C A;  1N13 A;  2SGP I;  1H0Z A;  1R0R I;  1BUS A;  1M8B A;  2SGF I;  2P6A C;  2KMR A;  1DS3 I;  1SGQ I;  1CHO I;  1NUB A;  1TUS A;  1PPF I;  5JHW C;  1SGP I;  2JYY A;  1YTP A;  2F3C I;  3QTL D;  1TBR R;  1SGD I;  2NU0 I;  2ARP F;  2XRC A;  1CGI I;  1CSO I;  1Z7K B;  2KMP A;  1DS2 I;  1AN1 I;  1Y1C A;  1SGY I;  3OVO A;  2KCX A;  3B4V C;  2GKV A;  1HJA I;  4HGU A;  4OVO A;  2N52 A;  2V53 A;  2QQD A;  1OMT A;  1BMO A;  2GKR I;  2OVO A;  2NU1 I; 
#chains in the Genus database with same CATH topology
 2PQ8 A;  2SGE I;  1CT2 I;  1OYV I;  1MT1 A;  4UXJ A;  5CCM A;  2ORV A;  2QPO A;  5EX0 A;  1KMA A;  1OMU A;  2N71 A;  2WCY A;  5FUW A;  1P9G A;  3QWP A;  1SGN I;  2SGD I;  2J87 A;  1LR9 A;  2K9H A;  1S20 A;  1FYB A;  2E73 A;  3FSY A;  1TGS I;  1CT0 I;  2ORW A;  2RIJ A;  1PCE A;  2J9R A;  2GKT I;  1V1I A;  1IY6 A;  5E3Q A;  1HPT A;  2M5X A;  4UXI A;  2JXD A;  1ULM A;  3TOA A;  2JZM A;  2L7X A;  3UGL A;  4UXH A;  2N17 A;  3MEK A;  1UUC A;  5HQ8 A;  1W3S A;  1TIH A;  2QQE A;  1WGC A;  4L9M A;  2CWH A;  1YU6 C;  2NU4 I;  2CWF A;  1R79 A;  4GI3 C;  4JCV E;  2QQ0 A;  1OVO A;  5DAE A;  1TBQ R;  1CGJ I;  3UEY A;  4AML A;  1CE3 A;  2BUS A;  1IW4 A;  4E1R A;  2QQC A;  3SGB I;  2NU2 I;  1PJU A;  1ULK A;  2CWG A;  2UZ3 A;  1LR7 A;  1CT4 I;  4FKD A;  3TOB A;  5HI7 A;  2LEO A;  3UGI A;  1UVF A;  4E1P A;  1NXU A;  4SGB I;  3UEJ A;  2UVO A;  3OXG A;  2V1C C;  3E59 A;  2ENN A;  1SGR I;  1Q9B A;  1Y1B A;  1MJ9 A;  5E3R A;  1PTR A;  1IY5 A;  1U5K A;  2NU3 I;  1MJA A;  2Y0M A;  2B0U C;  4B6D A;  2X52 A;  3VE5 A;  2YQP A;  1SGE I;  3RU0 A;  1HEV A;  1HDL A;  1FAR A;  1LR8 A;  2JA1 A;  5E3P A;  1UVG A;  1WGT A;  1V1H A;  2KMQ A;  5FUY A;  3R5B A;  1K7U A;  2KMO A;  3HH2 C;  3UGD A;  3OXF A;  1XX6 A;  4DNC A;  3FSX A;  9WGA A;  1TUR A;  2ERW A;  2DKV A;  1VDD A;  3SGQ I;  3PDN A;  3TJQ A;  3SEK C;  1RFH A;  2WVJ A;  2SGQ I;  1Z2I A;  1M8C A;  1N13 A;  1X74 A;  5CCL A;  2SGP I;  3FC3 A;  3KY9 A;  1H0Z A;  1R0R I;  1BUS A;  1Y8F A;  1FAQ A;  1M8B A;  4A24 A;  3QAH A;  3D00 A;  5J8F A;  2SGF I;  1XBT A;  2P6A C;  3TO7 A;  2V1C A;  2RC4 A;  2KMR A;  1TBN A;  1DS3 I;  1SGQ I;  2X3T A;  2YUU A;  1CHO I;  3BJI A;  2FNF X;  4WP4 A;  1TBO A;  1NUB A;  1TUS A;  2OD1 A;  1PPF I;  5JHW C;  3GOX A;  1K7T A;  3TO9 A;  3UFF A;  1ULN A;  1SGP I;  2JYY A;  1WKX A;  1YTP A;  2F3C I;  1TOT A;  1TBR R;  2CJS C;  1SGD I;  3QTL D;  4MPI A;  2NU0 I;  1K7V A;  3CXL A;  2ARP F;  1MJB A;  1UHA A;  1KBF A;  5EX3 A;  2XRC A;  3OL0 A;  1CGI I;  2DB6 A;  1CSO I;  5FUV A;  1WTJ A;  1Z7K B;  3R5D A;  2ELI A;  2KMP A;  2LUY A;  2ODD A;  1DS2 I;  1AN1 I;  1Y1C A;  5J8C A;  1SGY I;  3TO6 A;  3OVO A;  2ROW A;  2LB7 A;  2KCX A;  3R5C A;  2OU2 A;  2VRW B;  3B4V C;  2W0T A;  2GKV A;  2A20 A;  3E2I A;  2B8T A;  1HJA I;  1PTQ A;  2ENZ A;  2WGC A;  3VDU A;  2DIP A;  1XA6 A;  4HGU A;  7WGA A;  4OVO A;  2JW6 A;  2N52 A;  1X4S A;  1FY7 A;  2E5R A;  1KBE A;  2N1A B;  2OZU A;  3OXL A;  2V53 A;  1P9Z A;  2QQD A;  3UOE A;  1OMT A;  2GIV A;  1W4R A;  1BMO A;  2L8E A;  2GKR I;  3VDP A;  2OVO A;  2GVI A;  2NU1 I;  3R5A A;  5FUX A; 
#chains in the Genus database with same CATH homology
 2SGE I;  1CT2 I;  1OYV I;  1MT1 A;  4UXJ A;  5CCM A;  2ORV A;  2QPO A;  5EX0 A;  1KMA A;  1OMU A;  2N71 A;  2WCY A;  5FUW A;  3QWP A;  1SGN I;  2SGD I;  2J87 A;  1LR9 A;  2K9H A;  1FYB A;  2E73 A;  1TGS I;  1CT0 I;  2ORW A;  1PCE A;  2J9R A;  2GKT I;  1V1I A;  1IY6 A;  1HPT A;  2M5X A;  4UXI A;  2JXD A;  2JZM A;  2L7X A;  3UGL A;  4UXH A;  2N17 A;  3MEK A;  1UUC A;  5HQ8 A;  1W3S A;  1TIH A;  2QQE A;  4L9M A;  2NU4 I;  1YU6 C;  1R79 A;  4GI3 C;  4JCV E;  2QQ0 A;  1OVO A;  5DAE A;  1TBQ R;  1CGJ I;  3UEY A;  1CE3 A;  2BUS A;  1IW4 A;  4E1R A;  2QQC A;  3SGB I;  2NU2 I;  1PJU A;  2UZ3 A;  1LR7 A;  1CT4 I;  4FKD A;  3UGI A;  5HI7 A;  2LEO A;  4E1P A;  1UVF A;  4SGB I;  3UEJ A;  3OXG A;  2V1C C;  3E59 A;  2ENN A;  1SGR I;  1Y1B A;  1IY5 A;  1PTR A;  1U5K A;  2NU3 I;  2B0U C;  4B6D A;  3VE5 A;  2YQP A;  1SGE I;  3RU0 A;  1HDL A;  1FAR A;  1LR8 A;  2JA1 A;  1UVG A;  1V1H A;  2KMQ A;  5FUY A;  2KMO A;  3HH2 C;  3UGD A;  3OXF A;  1XX6 A;  1TUR A;  2ERW A;  1VDD A;  3SGQ I;  3PDN A;  3TJQ A;  3SEK C;  1RFH A;  2WVJ A;  2SGQ I;  1M8C A;  1N13 A;  1X74 A;  5CCL A;  2SGP I;  3FC3 A;  3KY9 A;  1H0Z A;  1R0R I;  1BUS A;  1Y8F A;  1FAQ A;  1M8B A;  4A24 A;  3D00 A;  2SGF I;  1XBT A;  2P6A C;  2V1C A;  2KMR A;  1TBN A;  1DS3 I;  1SGQ I;  2YUU A;  1CHO I;  3BJI A;  2FNF X;  1TBO A;  1NUB A;  1TUS A;  2OD1 A;  1PPF I;  5JHW C;  3GOX A;  3UFF A;  1SGP I;  2JYY A;  1YTP A;  2F3C I;  1TOT A;  1TBR R;  2CJS C;  1SGD I;  3QTL D;  2NU0 I;  3CXL A;  2ARP F;  1KBF A;  5EX3 A;  2XRC A;  3OL0 A;  1CGI I;  2DB6 A;  1CSO I;  5FUV A;  1Z7K B;  2ELI A;  2KMP A;  2LUY A;  2ODD A;  1DS2 I;  1AN1 I;  1Y1C A;  1SGY I;  3OVO A;  2ROW A;  2KCX A;  2VRW B;  3B4V C;  2W0T A;  2GKV A;  2A20 A;  3E2I A;  2B8T A;  1HJA I;  1PTQ A;  2ENZ A;  3VDU A;  2DIP A;  1XA6 A;  4HGU A;  4OVO A;  2JW6 A;  2N52 A;  1X4S A;  2E5R A;  1KBE A;  2N1A B;  3OXL A;  2V53 A;  2QQD A;  1OMT A;  1W4R A;  1BMO A;  2L8E A;  2GKR I;  3VDP A;  2OVO A;  2GVI A;  2NU1 I;  5FUX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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