2KMQA

Solution structure of intermediate iib of leech-derived tryptase inhibitor, ldti.
Total Genus 5
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
5
sequence length
44
structure length
44
Chain Sequence
KKVCACPKILKPVCGSDGRTYANSCIARCNGVSIKSEGSCPTGI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Deciphering the structural basis that guides the oxidative folding of leech-derived tryptase inhibitor.
pubmed doi rcsb
molecule tags Hydrolase
source organism Hirudo medicinalis
molecule keywords Leech-derived tryptase inhibitor C
total genus 5
structure length 44
sequence length 44
ec nomenclature
pdb deposition date 2009-08-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00050 Kazal_1 Kazal-type serine protease inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 2kmqA00
1OMTA 2SGFI 1IY5A 2SGPI 4HGUA 1SGDI 2KMRA 1N13A 1TBQR 1TGSI 2NU2I 2SGDI 1SGYI 2LEOA 5JHWC 1CGII 1UVGA 4GI3C 3SEKC 2WCYA 1OMUA 1CE3A 1BUSA 2OVOA 1M8CA 2KMQA 2JZMA 1IW4A 2NU3I 2GKVA 1SGNI 2QQCA 1R0RI 3SGQI 1YTPA 2ERWA 1HDLA 1UVFA 2XRCA 2NU1I 1MT1A 1BMOA 1DS2I 1M8BA 2ARPF 1YU6C 1CT2I 1HJAI 1KMAA 1CT4I 2KMOA 4SGBI 2BUSA 1Z7KB 1Y1BA 3TJQA 1SGRI 2B0UC 1HPTA 1DS3I 1UUCA 1SGEI 1IY6A 3QTLD 2F3CI 1SGQI 2M5XA 1LR9A 2JXDA 2SGEI 2QQDA 5DAEA 3HH2C 2SGQI 3B4VC 1AN1I 2KMPA 2GKTI 1TBRR 2NU0I 1PJUA 1CSOI 1CGJI 2JYYA 2N71A 2N52A 2NU4I 1FYBA 1NUBA 4OVOA 1LR7A 1TUSA 1CT0I 1OVOA 3SGBI 1OYVI 2V53A 2GKRI 2N17A 1TIHA 1CHOI 1PPFI 2P6AC 1SGPI 1Y1CA 1LR8A 1TURA 3OVOA 1H0ZA 1PCEA 2KCXA
chains in the Genus database with same CATH superfamily
1ULMA 1OMTA 2RIJA 5EX3A 3CXLA 2SGFI 2UZ3A 1IY5A 2DB6A 4FKDA 1V1HA 2SGPI 4HGUA 1SGDI 4E1PA 1Z2IA 2KMRA 5JHWC 1N13A 1TBQR 1Y8FA 1TGSI 2L8EA 2NU2I 1MJ9A 1KBFA 2FNFX 2QPOA 4AMLA 3OL0A 2SGDI 1SGYI 2L7XA 2LEOA 3VE5A 3TO7A 5HI7A 3UOEA 1CGII 4A24A 4E1RA 1UVGA 2J87A 4GI3C 2DKVA 2GIVA 2JA1A 3SEKC 3R5BA 3UGDA 2OD1A 4MPIA 3QWPA 3UGLA 2RC4A 2WCYA 5FUWA 3QAHA 1K7TA 1MJAA 1OMUA 3FSYA 1CE3A 3FSXA 1BUSA 2CJSC 2OVOA 5E3QA 1M8CA 3FC3A 1NXUA 1Q9BA 2W0TA 2ORVA 3UFFA 7WGAA 2KMQA 2JZMA 4UXHA 5CCLA 2Y0MA 2N1AB 1IW4A 2QQEA 2NU3I 2GKVA 1SGNI 2QQCA 3VDPA 1R0RI 2CWGA 3SGQI 1YTPA 2LB7A 3KY9A 2ERWA 1HDLA 3OXLA 1TBOA 1FY7A 1X74A 3BJIA 1PTRA 5E3PA 1W3SA 2OU2A 1UVFA 5FUYA 1XBTA 2NU1I 1MT1A 2XRCA 3OXFA 1X4SA 1BMOA 1DS2I 1M8BA 2ARPF 1YU6C 2E73A 1MJBA 4WP4A 4UXJA 1CT2I 1HJAI 3RU0A 1CT4I 2KMOA 1WGTA 2WVJA 1FAQA 1KMAA 1PTQA 2PQ8A 4SGBI 2BUSA 4DNCA 1Z7KB 5FUXA 1K7UA 1KBEA 1XA6A 1Y1BA 2ROWA 2WGCA 3TJQA 1SGRI 2ENNA 2B0UC 1VDDA 1HPTA 2V1CC 5CCMA 1WTJA 1DS3I 1UUCA 3R5DA 1SGEI 3GOXA 1IY6A 2ENZA 3QTLD 2F3CI 1SGQI 2M5XA 1LR9A 5EX0A 2JXDA 2V1CA 2SGEI 3R5CA 2QQDA 1RFHA 5DAEA 2GVIA 5HQ8A 2ELIA 2ORWA 3HH2C 2SGQI 3B4VC 1AN1I 2JW6A 2X3TA 4L9MA 2KMPA 1U5KA 2GKTI 1S20A 5J8FA 3UGIA 2E5RA 1TBRR 1PJUA 2NU0I 1CSOI 1CGJI 2J9RA 2JYYA 2K9HA 2N71A 2X52A 2YQPA 5J8CA 2N52A 1XX6A 1P9ZA 2NU4I 3VDUA 3PDNA 2YUUA 1NUBA 2A20A 5E3RA 3UEYA 1W4RA 1FYBA 4OVOA 1LR7A 4B6DA 1TUSA 3E59A 3TO6A 3TOBA 3MEKA 1V1IA 1TOTA 2B8TA 3D00A 5FUVA 2LUYA 2UVOA 1CT0I 1OVOA 1R79A 1UHAA 3SGBI 3TO9A 1TBNA 1K7VA 1ULKA 3R5AA 1OYVI 1HEVA 2V53A 4UXIA 2ODDA 2QQ0A 1ULNA 2CWHA 4JCVE 2GKRI 1FARA 2N17A 1TIHA 2VRWB 3UEJA 9WGAA 3OXGA 2DIPA 1CHOI 3E2IA 1PPFI 2P6AC 1WGCA 3TOAA 1SGPI 1Y1CA 1LR8A 2CWFA 1TURA 3OVOA 1P9GA 1H0ZA 1PCEA 2OZUA 1WKXA 2KCXA
chains in the Genus database with same CATH topology
1OMTA 5EX3A 3CXLA 2SGFI 2UZ3A 1IY5A 2DB6A 4FKDA 1V1HA 2SGPI 4HGUA 1SGDI 4E1PA 2KMRA 1N13A 1TBQR 1Y8FA 1TGSI 2L8EA 2NU2I 1KBFA 2FNFX 2QPOA 3OL0A 2SGDI 1SGYI 2L7XA 2LEOA 3VE5A 5JHWC 5HI7A 4E1RA 1CGII 4A24A 1UVGA 2J87A 4GI3C 2JA1A 3SEKC 3UGDA 2OD1A 3QWPA 3UGLA 2WCYA 5FUWA 1OMUA 1CE3A 1BUSA 2CJSC 2OVOA 1M8CA 3FC3A 2W0TA 2ORVA 3UFFA 2KMQA 2JZMA 4UXHA 5CCLA 2N1AB 1IW4A 2QQEA 2NU3I 2GKVA 1SGNI 2QQCA 3VDPA 1R0RI 3SGQI 1YTPA 3KY9A 2ERWA 1HDLA 3OXLA 1TBOA 1X74A 3BJIA 1PTRA 1W3SA 1UVFA 5FUYA 1XBTA 2NU1I 1MT1A 2XRCA 3OXFA 1X4SA 1BMOA 1DS2I 1M8BA 2ARPF 1YU6C 2E73A 4UXJA 1CT2I 1HJAI 3RU0A 1CT4I 2KMOA 2WVJA 1KMAA 1FAQA 1PTQA 4SGBI 2BUSA 1Z7KB 5FUXA 1XA6A 1KBEA 1Y1BA 2ROWA 3TJQA 1SGRI 2ENNA 2B0UC 1VDDA 1HPTA 2V1CC 5CCMA 1DS3I 1UUCA 1SGEI 3GOXA 1IY6A 2ENZA 3QTLD 2F3CI 1SGQI 2M5XA 1LR9A 5EX0A 2JXDA 2V1CA 2SGEI 2QQDA 1RFHA 5DAEA 2GVIA 5HQ8A 2ELIA 2ORWA 3HH2C 2SGQI 3B4VC 1AN1I 2JW6A 4L9MA 2KMPA 1U5KA 2GKTI 3UGIA 2E5RA 1TBRR 1PJUA 2NU0I 1CSOI 1CGJI 2J9RA 2JYYA 2K9HA 2N71A 2YQPA 2N52A 1XX6A 2NU4I 3VDUA 3PDNA 2YUUA 1NUBA 2A20A 3UEYA 1FYBA 1W4RA 4OVOA 1LR7A 4B6DA 1TUSA 3E59A 3MEKA 1V1IA 1TOTA 2B8TA 3D00A 5FUVA 2LUYA 1CT0I 1OVOA 1R79A 3SGBI 1TBNA 1OYVI 2V53A 4UXIA 2ODDA 2QQ0A 4JCVE 2GKRI 1FARA 2N17A 1TIHA 2VRWB 3UEJA 3OXGA 2DIPA 1CHOI 3E2IA 1PPFI 2P6AC 1SGPI 1Y1CA 1LR8A 1TURA 3OVOA 1H0ZA 1PCEA 2KCXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1OMT A;  2SGF I;  1IY5 A;  2SGP I;  4HGU A;  1SGD I;  2KMR A;  1N13 A;  1TBQ R;  1TGS I;  2NU2 I;  2SGD I;  1SGY I;  2LEO A;  5JHW C;  1CGI I;  1UVG A;  4GI3 C;  3SEK C;  2WCY A;  1OMU A;  1CE3 A;  1BUS A;  2OVO A;  1M8C A;  2KMQ A;  2JZM A;  1IW4 A;  2NU3 I;  2GKV A;  1SGN I;  2QQC A;  1R0R I;  3SGQ I;  1YTP A;  2ERW A;  1HDL A;  1UVF A;  2XRC A;  2NU1 I;  1MT1 A;  1BMO A;  1DS2 I;  1M8B A;  2ARP F;  1YU6 C;  1CT2 I;  1HJA I;  1KMA A;  1CT4 I;  2KMO A;  4SGB I;  2BUS A;  1Z7K B;  1Y1B A;  3TJQ A;  1SGR I;  2B0U C;  1HPT A;  1DS3 I;  1UUC A;  1SGE I;  1IY6 A;  3QTL D;  2F3C I;  1SGQ I;  2M5X A;  1LR9 A;  2JXD A;  2SGE I;  2QQD A;  5DAE A;  3HH2 C;  2SGQ I;  3B4V C;  1AN1 I;  2KMP A;  2GKT I;  1TBR R;  2NU0 I;  1PJU A;  1CSO I;  1CGJ I;  2JYY A;  2N71 A;  2N52 A;  2NU4 I;  1FYB A;  1NUB A;  4OVO A;  1LR7 A;  1TUS A;  1CT0 I;  1OVO A;  3SGB I;  1OYV I;  2V53 A;  2GKR I;  2N17 A;  1TIH A;  1CHO I;  1PPF I;  2P6A C;  1SGP I;  1Y1C A;  1LR8 A;  1TUR A;  3OVO A;  1H0Z A;  1PCE A;  2KCX A; 
#chains in the Genus database with same CATH topology
 1ULM A;  1OMT A;  2RIJ A;  5EX3 A;  3CXL A;  2SGF I;  2UZ3 A;  1IY5 A;  2DB6 A;  4FKD A;  1V1H A;  2SGP I;  4HGU A;  1SGD I;  4E1P A;  1Z2I A;  2KMR A;  5JHW C;  1N13 A;  1TBQ R;  1Y8F A;  1TGS I;  2L8E A;  2NU2 I;  1MJ9 A;  1KBF A;  2FNF X;  2QPO A;  4AML A;  3OL0 A;  2SGD I;  1SGY I;  2L7X A;  2LEO A;  3VE5 A;  3TO7 A;  5HI7 A;  3UOE A;  1CGI I;  4A24 A;  4E1R A;  1UVG A;  2J87 A;  4GI3 C;  2DKV A;  2GIV A;  2JA1 A;  3SEK C;  3R5B A;  3UGD A;  2OD1 A;  4MPI A;  3QWP A;  3UGL A;  2RC4 A;  2WCY A;  5FUW A;  3QAH A;  1K7T A;  1MJA A;  1OMU A;  3FSY A;  1CE3 A;  3FSX A;  1BUS A;  2CJS C;  2OVO A;  5E3Q A;  1M8C A;  3FC3 A;  1NXU A;  1Q9B A;  2W0T A;  2ORV A;  3UFF A;  7WGA A;  2KMQ A;  2JZM A;  4UXH A;  5CCL A;  2Y0M A;  2N1A B;  1IW4 A;  2QQE A;  2NU3 I;  2GKV A;  1SGN I;  2QQC A;  3VDP A;  1R0R I;  2CWG A;  3SGQ I;  1YTP A;  2LB7 A;  3KY9 A;  2ERW A;  1HDL A;  3OXL A;  1TBO A;  1FY7 A;  1X74 A;  3BJI A;  1PTR A;  5E3P A;  1W3S A;  2OU2 A;  1UVF A;  5FUY A;  1XBT A;  2NU1 I;  1MT1 A;  2XRC A;  3OXF A;  1X4S A;  1BMO A;  1DS2 I;  1M8B A;  2ARP F;  1YU6 C;  2E73 A;  1MJB A;  4WP4 A;  4UXJ A;  1CT2 I;  1HJA I;  3RU0 A;  1CT4 I;  2KMO A;  1WGT A;  2WVJ A;  1FAQ A;  1KMA A;  1PTQ A;  2PQ8 A;  4SGB I;  2BUS A;  4DNC A;  1Z7K B;  5FUX A;  1K7U A;  1KBE A;  1XA6 A;  1Y1B A;  2ROW A;  2WGC A;  3TJQ A;  1SGR I;  2ENN A;  2B0U C;  1VDD A;  1HPT A;  2V1C C;  5CCM A;  1WTJ A;  1DS3 I;  1UUC A;  3R5D A;  1SGE I;  3GOX A;  1IY6 A;  2ENZ A;  3QTL D;  2F3C I;  1SGQ I;  2M5X A;  1LR9 A;  5EX0 A;  2JXD A;  2V1C A;  2SGE I;  3R5C A;  2QQD A;  1RFH A;  5DAE A;  2GVI A;  5HQ8 A;  2ELI A;  2ORW A;  3HH2 C;  2SGQ I;  3B4V C;  1AN1 I;  2JW6 A;  2X3T A;  4L9M A;  2KMP A;  1U5K A;  2GKT I;  1S20 A;  5J8F A;  3UGI A;  2E5R A;  1TBR R;  1PJU A;  2NU0 I;  1CSO I;  1CGJ I;  2J9R A;  2JYY A;  2K9H A;  2N71 A;  2X52 A;  2YQP A;  5J8C A;  2N52 A;  1XX6 A;  1P9Z A;  2NU4 I;  3VDU A;  3PDN A;  2YUU A;  1NUB A;  2A20 A;  5E3R A;  3UEY A;  1W4R A;  1FYB A;  4OVO A;  1LR7 A;  4B6D A;  1TUS A;  3E59 A;  3TO6 A;  3TOB A;  3MEK A;  1V1I A;  1TOT A;  2B8T A;  3D00 A;  5FUV A;  2LUY A;  2UVO A;  1CT0 I;  1OVO A;  1R79 A;  1UHA A;  3SGB I;  3TO9 A;  1TBN A;  1K7V A;  1ULK A;  3R5A A;  1OYV I;  1HEV A;  2V53 A;  4UXI A;  2ODD A;  2QQ0 A;  1ULN A;  2CWH A;  4JCV E;  2GKR I;  1FAR A;  2N17 A;  1TIH A;  2VRW B;  3UEJ A;  9WGA A;  3OXG A;  2DIP A;  1CHO I;  3E2I A;  1PPF I;  2P6A C;  1WGC A;  3TOA A;  1SGP I;  1Y1C A;  1LR8 A;  2CWF A;  1TUR A;  3OVO A;  1P9G A;  1H0Z A;  1PCE A;  2OZU A;  1WKX A;  2KCX A; 
#chains in the Genus database with same CATH homology
 1OMT A;  5EX3 A;  3CXL A;  2SGF I;  2UZ3 A;  1IY5 A;  2DB6 A;  4FKD A;  1V1H A;  2SGP I;  4HGU A;  1SGD I;  4E1P A;  2KMR A;  1N13 A;  1TBQ R;  1Y8F A;  1TGS I;  2L8E A;  2NU2 I;  1KBF A;  2FNF X;  2QPO A;  3OL0 A;  2SGD I;  1SGY I;  2L7X A;  2LEO A;  3VE5 A;  5JHW C;  5HI7 A;  4E1R A;  1CGI I;  4A24 A;  1UVG A;  2J87 A;  4GI3 C;  2JA1 A;  3SEK C;  3UGD A;  2OD1 A;  3QWP A;  3UGL A;  2WCY A;  5FUW A;  1OMU A;  1CE3 A;  1BUS A;  2CJS C;  2OVO A;  1M8C A;  3FC3 A;  2W0T A;  2ORV A;  3UFF A;  2KMQ A;  2JZM A;  4UXH A;  5CCL A;  2N1A B;  1IW4 A;  2QQE A;  2NU3 I;  2GKV A;  1SGN I;  2QQC A;  3VDP A;  1R0R I;  3SGQ I;  1YTP A;  3KY9 A;  2ERW A;  1HDL A;  3OXL A;  1TBO A;  1X74 A;  3BJI A;  1PTR A;  1W3S A;  1UVF A;  5FUY A;  1XBT A;  2NU1 I;  1MT1 A;  2XRC A;  3OXF A;  1X4S A;  1BMO A;  1DS2 I;  1M8B A;  2ARP F;  1YU6 C;  2E73 A;  4UXJ A;  1CT2 I;  1HJA I;  3RU0 A;  1CT4 I;  2KMO A;  2WVJ A;  1KMA A;  1FAQ A;  1PTQ A;  4SGB I;  2BUS A;  1Z7K B;  5FUX A;  1XA6 A;  1KBE A;  1Y1B A;  2ROW A;  3TJQ A;  1SGR I;  2ENN A;  2B0U C;  1VDD A;  1HPT A;  2V1C C;  5CCM A;  1DS3 I;  1UUC A;  1SGE I;  3GOX A;  1IY6 A;  2ENZ A;  3QTL D;  2F3C I;  1SGQ I;  2M5X A;  1LR9 A;  5EX0 A;  2JXD A;  2V1C A;  2SGE I;  2QQD A;  1RFH A;  5DAE A;  2GVI A;  5HQ8 A;  2ELI A;  2ORW A;  3HH2 C;  2SGQ I;  3B4V C;  1AN1 I;  2JW6 A;  4L9M A;  2KMP A;  1U5K A;  2GKT I;  3UGI A;  2E5R A;  1TBR R;  1PJU A;  2NU0 I;  1CSO I;  1CGJ I;  2J9R A;  2JYY A;  2K9H A;  2N71 A;  2YQP A;  2N52 A;  1XX6 A;  2NU4 I;  3VDU A;  3PDN A;  2YUU A;  1NUB A;  2A20 A;  3UEY A;  1FYB A;  1W4R A;  4OVO A;  1LR7 A;  4B6D A;  1TUS A;  3E59 A;  3MEK A;  1V1I A;  1TOT A;  2B8T A;  3D00 A;  5FUV A;  2LUY A;  1CT0 I;  1OVO A;  1R79 A;  3SGB I;  1TBN A;  1OYV I;  2V53 A;  4UXI A;  2ODD A;  2QQ0 A;  4JCV E;  2GKR I;  1FAR A;  2N17 A;  1TIH A;  2VRW B;  3UEJ A;  3OXG A;  2DIP A;  1CHO I;  3E2I A;  1PPF I;  2P6A C;  1SGP I;  1Y1C A;  1LR8 A;  1TUR A;  3OVO A;  1H0Z A;  1PCE A;  2KCX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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