2KMRA

Solution structure of intermediate iic of leech-derived tryptase inhibitor, ldti.
Total Genus 4
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
4
sequence length
44
structure length
44
Chain Sequence
KKVCACPKILKPVCGSDGRTYANSCIARCNGVSIKSEGSCPTGI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Deciphering the structural basis that guides the oxidative folding of leech-derived tryptase inhibitor.
pubmed doi rcsb
molecule tags Hydrolase
source organism Hirudo medicinalis
molecule keywords Leech-derived tryptase inhibitor C
total genus 4
structure length 44
sequence length 44
ec nomenclature
pdb deposition date 2009-08-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00050 Kazal_1 Kazal-type serine protease inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 2kmrA01
1M8CA 1TGSI 1CT0I 2NU2I 1Y1BA 1IW4A 1SGEI 2N71A 2F3CI 2JXDA 2JZMA 1CT2I 2N17A 1DS2I 3OVOA 1OYVI 2OVOA 1M8BA 2JYYA 1OMUA 2N52A 2QQDA 2P6AC 1BMOA 2SGDI 1N13A 1CHOI 1SGQI 1CGJI 4OVOA 1PPFI 1TBRR 1CE3A 1Y1CA 2GKVA 5DAEA 2NU1I 1CSOI 1TBQR 1TIHA 2V53A 1AN1I 2QQCA 2BUSA 1SGPI 3TJQA 1CT4I 3QTLD 1BUSA 2SGEI 1HDLA 2SGPI 1NUBA 2WCYA 1CGII 3B4VC 2SGFI 1UVFA 3SGBI 2XRCA 1IY6A 2LEOA 1Z7KB 1SGRI 3SEKC 1R0RI 1LR8A 1DS3I 2SGQI 1IY5A 1HPTA 1PCEA 5JHWC 2KMQA 2NU0I 1LR9A 4GI3C 2KCXA 1SGNI 2NU4I 1YTPA 2NU3I 1TUSA 2KMOA 2KMRA 1OMTA 3SGQI 2M5XA 1YU6C 1SGDI 1MT1A 2B0UC 2ARPF 1PJUA 4HGUA 1FYBA 3HH2C 2KMPA 4SGBI 2ERWA 1SGYI 1OVOA 1LR7A 2GKTI 1UUCA 1UVGA 1KMAA 1TURA 1HJAI 2GKRI 1H0ZA
chains in the Genus database with same CATH superfamily
1V1HA 2QPOA 1M8CA 5CCLA 1TGSI 3UEJA 1CT0I 3CXLA 1ULKA 2NU2I 1Y1BA 2OD1A 1IW4A 5HI7A 1MJBA 1SGEI 1FY7A 3TOAA 2ORVA 2ORWA 2RC4A 5CCMA 3OXGA 2GIVA 2N71A 2CWHA 2F3CI 2OU2A 3TO9A 2JXDA 3R5AA 3R5CA 1ULNA 1XBTA 3FC3A 2JZMA 2E73A 2ODDA 1CT2I 2N17A 1WTJA 3OL0A 2YUUA 2OZUA 1DS2I 2N1AB 3FSXA 3E59A 3OVOA 1OYVI 2K9HA 2L8EA 1W3SA 2OVOA 1TBOA 1FARA 1M8BA 2JW6A 1PTQA 2JYYA 3UFFA 1WGCA 2W0TA 2LB7A 1OMUA 4AMLA 1KBFA 2N52A 2QQDA 2L7XA 1TBNA 4UXHA 1VDDA 2UZ3A 1NXUA 2P6AC 5E3RA 3VDPA 5EX0A 3QAHA 3UGLA 1BMOA 4WP4A 4E1RA 1UHAA 1Y8FA 1P9ZA 2SGDI 4MPIA 1N13A 3OXFA 1CHOI 1SGQI 1CGJI 4OVOA 5E3QA 5J8CA 1PPFI 1TBRR 2CJSC 1X4SA 4E1PA 1RFHA 2DB6A 1V1IA 2WVJA 3E2IA 3TOBA 3VE5A 1CE3A 1Y1CA 2GKVA 3GOXA 2CWFA 5DAEA 1W4RA 2NU1I 1CSOI 1S20A 1TBQR 1TIHA 2DKVA 1AN1I 2V53A 2V1CC 4L9MA 2QQCA 3KY9A 2BUSA 1XX6A 1R79A 2CWGA 2DIPA 1SGPI 3MEKA 3TJQA 2ENZA 1CT4I 3QTLD 2LUYA 1BUSA 2A20A 1Q9BA 2SGEI 1HDLA 2SGPI 2X52A 1NUBA 2WCYA 1CGII 3B4VC 2SGFI 2UVOA 5FUWA 1Z2IA 2X3TA 2YQPA 5J8FA 1UVFA 3SGBI 2XRCA 1X74A 4UXIA 3RU0A 3UGIA 9WGAA 2WGCA 3UGDA 2LEOA 3OXLA 1IY6A 1PTRA 1XA6A 1Z7KB 2FNFX 2J87A 1SGRI 2QQEA 4FKDA 5FUYA 4B6DA 3SEKC 1R0RI 2VRWB 2PQ8A 1LR8A 1DS3I 2E5RA 2SGQI 3QWPA 1IY5A 1HPTA 1PCEA 3R5DA 1P9GA 3UEYA 5FUVA 1WKXA 5JHWC 2KMQA 1FAQA 2B8TA 4DNCA 1WGTA 3R5BA 1KBEA 3UOEA 2NU0I 5EX3A 1LR9A 1TOTA 3BJIA 1MJAA 2ELIA 1SGNI 2ENNA 2GVIA 2KCXA 2NU4I 2ROWA 3PDNA 4GI3C 4UXJA 3TO7A 1YTPA 2NU3I 1K7UA 1TUSA 2KMOA 2KMRA 3VDUA 2V1CA 1K7VA 1OMTA 2J9RA 3SGQI 2M5XA 4A24A 5FUXA 5E3PA 3TO6A 1YU6C 2JA1A 1SGDI 1MT1A 2B0UC 4JCVE 2ARPF 1PJUA 4HGUA 1FYBA 3HH2C 2KMPA 1HEVA 4SGBI 2ERWA 1SGYI 1OVOA 1LR7A 2GKTI 1U5KA 1UUCA 1K7TA 1UVGA 2QQ0A 2RIJA 3FSYA 5HQ8A 1KMAA 1TURA 2Y0MA 7WGAA 1MJ9A 1HJAI 1ULMA 2GKRI 1H0ZA 3D00A
chains in the Genus database with same CATH topology
1V1HA 2QPOA 1M8CA 5CCLA 1TGSI 3UEJA 1CT0I 3CXLA 2NU2I 1Y1BA 2OD1A 1IW4A 5HI7A 1SGEI 2ORVA 2ORWA 5CCMA 3OXGA 2N71A 2F3CI 2JXDA 1XBTA 3FC3A 2JZMA 2E73A 2ODDA 1CT2I 2N17A 3OL0A 2YUUA 1DS2I 2N1AB 3OVOA 3E59A 1OYVI 2K9HA 2L8EA 1W3SA 2OVOA 1TBOA 1FARA 1M8BA 2JW6A 1PTQA 2JYYA 3UFFA 1OMUA 1KBFA 2N52A 2QQDA 2L7XA 1TBNA 4UXHA 1VDDA 2UZ3A 2P6AC 3VDPA 5EX0A 3UGLA 1BMOA 4E1RA 1Y8FA 2SGDI 1N13A 3OXFA 1CHOI 1SGQI 1CGJI 4OVOA 1PPFI 1TBRR 2CJSC 1X4SA 4E1PA 1RFHA 2DB6A 1V1IA 2WVJA 3E2IA 3VE5A 1CE3A 1Y1CA 2GKVA 3GOXA 5DAEA 1W4RA 2NU1I 1CSOI 1TBQR 1TIHA 2V53A 1AN1I 2V1CC 4L9MA 2QQCA 3KY9A 2BUSA 1XX6A 1R79A 2DIPA 3MEKA 1SGPI 3TJQA 2ENZA 1CT4I 3QTLD 2LUYA 1BUSA 2A20A 2SGEI 1HDLA 2SGPI 1NUBA 2WCYA 1CGII 3B4VC 2SGFI 5FUWA 2YQPA 1UVFA 3SGBI 2XRCA 1X74A 4UXIA 3RU0A 3UGIA 1IY6A 3UGDA 2LEOA 3OXLA 1PTRA 1XA6A 1Z7KB 2FNFX 2J87A 1SGRI 2QQEA 4FKDA 5FUYA 4B6DA 3SEKC 1R0RI 2VRWB 1LR8A 1DS3I 2E5RA 2SGQI 3QWPA 1IY5A 1HPTA 1PCEA 3UEYA 5FUVA 5JHWC 2KMQA 1FAQA 2B8TA 1KBEA 2NU0I 5EX3A 1LR9A 1TOTA 3BJIA 2ELIA 2GVIA 1SGNI 2ENNA 2KCXA 2NU4I 2ROWA 3PDNA 4GI3C 4UXJA 1YTPA 2NU3I 3VDUA 1TUSA 2KMOA 2KMRA 2V1CA 1OMTA 2J9RA 3SGQI 2M5XA 4A24A 5FUXA 1YU6C 2JA1A 1SGDI 1MT1A 2B0UC 4JCVE 2ARPF 1PJUA 4HGUA 1FYBA 3HH2C 2KMPA 4SGBI 2ERWA 1SGYI 1OVOA 1LR7A 2GKTI 1U5KA 1UUCA 1UVGA 2QQ0A 5HQ8A 1KMAA 1TURA 1HJAI 2W0TA 2GKRI 1H0ZA 3D00A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1M8C A;  1TGS I;  1CT0 I;  2NU2 I;  1Y1B A;  1IW4 A;  1SGE I;  2N71 A;  2F3C I;  2JXD A;  2JZM A;  1CT2 I;  2N17 A;  1DS2 I;  3OVO A;  1OYV I;  2OVO A;  1M8B A;  2JYY A;  1OMU A;  2N52 A;  2QQD A;  2P6A C;  1BMO A;  2SGD I;  1N13 A;  1CHO I;  1SGQ I;  1CGJ I;  4OVO A;  1PPF I;  1TBR R;  1CE3 A;  1Y1C A;  2GKV A;  5DAE A;  2NU1 I;  1CSO I;  1TBQ R;  1TIH A;  2V53 A;  1AN1 I;  2QQC A;  2BUS A;  1SGP I;  3TJQ A;  1CT4 I;  3QTL D;  1BUS A;  2SGE I;  1HDL A;  2SGP I;  1NUB A;  2WCY A;  1CGI I;  3B4V C;  2SGF I;  1UVF A;  3SGB I;  2XRC A;  1IY6 A;  2LEO A;  1Z7K B;  1SGR I;  3SEK C;  1R0R I;  1LR8 A;  1DS3 I;  2SGQ I;  1IY5 A;  1HPT A;  1PCE A;  5JHW C;  2KMQ A;  2NU0 I;  1LR9 A;  4GI3 C;  2KCX A;  1SGN I;  2NU4 I;  1YTP A;  2NU3 I;  1TUS A;  2KMO A;  2KMR A;  1OMT A;  3SGQ I;  2M5X A;  1YU6 C;  1SGD I;  1MT1 A;  2B0U C;  2ARP F;  1PJU A;  4HGU A;  1FYB A;  3HH2 C;  2KMP A;  4SGB I;  2ERW A;  1SGY I;  1OVO A;  1LR7 A;  2GKT I;  1UUC A;  1UVG A;  1KMA A;  1TUR A;  1HJA I;  2GKR I;  1H0Z A; 
#chains in the Genus database with same CATH topology
 1V1H A;  2QPO A;  1M8C A;  5CCL A;  1TGS I;  3UEJ A;  1CT0 I;  3CXL A;  1ULK A;  2NU2 I;  1Y1B A;  2OD1 A;  1IW4 A;  5HI7 A;  1MJB A;  1SGE I;  1FY7 A;  3TOA A;  2ORV A;  2ORW A;  2RC4 A;  5CCM A;  3OXG A;  2GIV A;  2N71 A;  2CWH A;  2F3C I;  2OU2 A;  3TO9 A;  2JXD A;  3R5A A;  3R5C A;  1ULN A;  1XBT A;  3FC3 A;  2JZM A;  2E73 A;  2ODD A;  1CT2 I;  2N17 A;  1WTJ A;  3OL0 A;  2YUU A;  2OZU A;  1DS2 I;  2N1A B;  3FSX A;  3E59 A;  3OVO A;  1OYV I;  2K9H A;  2L8E A;  1W3S A;  2OVO A;  1TBO A;  1FAR A;  1M8B A;  2JW6 A;  1PTQ A;  2JYY A;  3UFF A;  1WGC A;  2W0T A;  2LB7 A;  1OMU A;  4AML A;  1KBF A;  2N52 A;  2QQD A;  2L7X A;  1TBN A;  4UXH A;  1VDD A;  2UZ3 A;  1NXU A;  2P6A C;  5E3R A;  3VDP A;  5EX0 A;  3QAH A;  3UGL A;  1BMO A;  4WP4 A;  4E1R A;  1UHA A;  1Y8F A;  1P9Z A;  2SGD I;  4MPI A;  1N13 A;  3OXF A;  1CHO I;  1SGQ I;  1CGJ I;  4OVO A;  5E3Q A;  5J8C A;  1PPF I;  1TBR R;  2CJS C;  1X4S A;  4E1P A;  1RFH A;  2DB6 A;  1V1I A;  2WVJ A;  3E2I A;  3TOB A;  3VE5 A;  1CE3 A;  1Y1C A;  2GKV A;  3GOX A;  2CWF A;  5DAE A;  1W4R A;  2NU1 I;  1CSO I;  1S20 A;  1TBQ R;  1TIH A;  2DKV A;  1AN1 I;  2V53 A;  2V1C C;  4L9M A;  2QQC A;  3KY9 A;  2BUS A;  1XX6 A;  1R79 A;  2CWG A;  2DIP A;  1SGP I;  3MEK A;  3TJQ A;  2ENZ A;  1CT4 I;  3QTL D;  2LUY A;  1BUS A;  2A20 A;  1Q9B A;  2SGE I;  1HDL A;  2SGP I;  2X52 A;  1NUB A;  2WCY A;  1CGI I;  3B4V C;  2SGF I;  2UVO A;  5FUW A;  1Z2I A;  2X3T A;  2YQP A;  5J8F A;  1UVF A;  3SGB I;  2XRC A;  1X74 A;  4UXI A;  3RU0 A;  3UGI A;  9WGA A;  2WGC A;  3UGD A;  2LEO A;  3OXL A;  1IY6 A;  1PTR A;  1XA6 A;  1Z7K B;  2FNF X;  2J87 A;  1SGR I;  2QQE A;  4FKD A;  5FUY A;  4B6D A;  3SEK C;  1R0R I;  2VRW B;  2PQ8 A;  1LR8 A;  1DS3 I;  2E5R A;  2SGQ I;  3QWP A;  1IY5 A;  1HPT A;  1PCE A;  3R5D A;  1P9G A;  3UEY A;  5FUV A;  1WKX A;  5JHW C;  2KMQ A;  1FAQ A;  2B8T A;  4DNC A;  1WGT A;  3R5B A;  1KBE A;  3UOE A;  2NU0 I;  5EX3 A;  1LR9 A;  1TOT A;  3BJI A;  1MJA A;  2ELI A;  1SGN I;  2ENN A;  2GVI A;  2KCX A;  2NU4 I;  2ROW A;  3PDN A;  4GI3 C;  4UXJ A;  3TO7 A;  1YTP A;  2NU3 I;  1K7U A;  1TUS A;  2KMO A;  2KMR A;  3VDU A;  2V1C A;  1K7V A;  1OMT A;  2J9R A;  3SGQ I;  2M5X A;  4A24 A;  5FUX A;  5E3P A;  3TO6 A;  1YU6 C;  2JA1 A;  1SGD I;  1MT1 A;  2B0U C;  4JCV E;  2ARP F;  1PJU A;  4HGU A;  1FYB A;  3HH2 C;  2KMP A;  1HEV A;  4SGB I;  2ERW A;  1SGY I;  1OVO A;  1LR7 A;  2GKT I;  1U5K A;  1UUC A;  1K7T A;  1UVG A;  2QQ0 A;  2RIJ A;  3FSY A;  5HQ8 A;  1KMA A;  1TUR A;  2Y0M A;  7WGA A;  1MJ9 A;  1HJA I;  1ULM A;  2GKR I;  1H0Z A;  3D00 A; 
#chains in the Genus database with same CATH homology
 1V1H A;  2QPO A;  1M8C A;  5CCL A;  1TGS I;  3UEJ A;  1CT0 I;  3CXL A;  2NU2 I;  1Y1B A;  2OD1 A;  1IW4 A;  5HI7 A;  1SGE I;  2ORV A;  2ORW A;  5CCM A;  3OXG A;  2N71 A;  2F3C I;  2JXD A;  1XBT A;  3FC3 A;  2JZM A;  2E73 A;  2ODD A;  1CT2 I;  2N17 A;  3OL0 A;  2YUU A;  1DS2 I;  2N1A B;  3OVO A;  3E59 A;  1OYV I;  2K9H A;  2L8E A;  1W3S A;  2OVO A;  1TBO A;  1FAR A;  1M8B A;  2JW6 A;  1PTQ A;  2JYY A;  3UFF A;  1OMU A;  1KBF A;  2N52 A;  2QQD A;  2L7X A;  1TBN A;  4UXH A;  1VDD A;  2UZ3 A;  2P6A C;  3VDP A;  5EX0 A;  3UGL A;  1BMO A;  4E1R A;  1Y8F A;  2SGD I;  1N13 A;  3OXF A;  1CHO I;  1SGQ I;  1CGJ I;  4OVO A;  1PPF I;  1TBR R;  2CJS C;  1X4S A;  4E1P A;  1RFH A;  2DB6 A;  1V1I A;  2WVJ A;  3E2I A;  3VE5 A;  1CE3 A;  1Y1C A;  2GKV A;  3GOX A;  5DAE A;  1W4R A;  2NU1 I;  1CSO I;  1TBQ R;  1TIH A;  2V53 A;  1AN1 I;  2V1C C;  4L9M A;  2QQC A;  3KY9 A;  2BUS A;  1XX6 A;  1R79 A;  2DIP A;  3MEK A;  1SGP I;  3TJQ A;  2ENZ A;  1CT4 I;  3QTL D;  2LUY A;  1BUS A;  2A20 A;  2SGE I;  1HDL A;  2SGP I;  1NUB A;  2WCY A;  1CGI I;  3B4V C;  2SGF I;  5FUW A;  2YQP A;  1UVF A;  3SGB I;  2XRC A;  1X74 A;  4UXI A;  3RU0 A;  3UGI A;  1IY6 A;  3UGD A;  2LEO A;  3OXL A;  1PTR A;  1XA6 A;  1Z7K B;  2FNF X;  2J87 A;  1SGR I;  2QQE A;  4FKD A;  5FUY A;  4B6D A;  3SEK C;  1R0R I;  2VRW B;  1LR8 A;  1DS3 I;  2E5R A;  2SGQ I;  3QWP A;  1IY5 A;  1HPT A;  1PCE A;  3UEY A;  5FUV A;  5JHW C;  2KMQ A;  1FAQ A;  2B8T A;  1KBE A;  2NU0 I;  5EX3 A;  1LR9 A;  1TOT A;  3BJI A;  2ELI A;  2GVI A;  1SGN I;  2ENN A;  2KCX A;  2NU4 I;  2ROW A;  3PDN A;  4GI3 C;  4UXJ A;  1YTP A;  2NU3 I;  3VDU A;  1TUS A;  2KMO A;  2KMR A;  2V1C A;  1OMT A;  2J9R A;  3SGQ I;  2M5X A;  4A24 A;  5FUX A;  1YU6 C;  2JA1 A;  1SGD I;  1MT1 A;  2B0U C;  4JCV E;  2ARP F;  1PJU A;  4HGU A;  1FYB A;  3HH2 C;  2KMP A;  4SGB I;  2ERW A;  1SGY I;  1OVO A;  1LR7 A;  2GKT I;  1U5K A;  1UUC A;  1UVG A;  2QQ0 A;  5HQ8 A;  1KMA A;  1TUR A;  1HJA I;  2W0T A;  2GKR I;  1H0Z A;  3D00 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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