3TJQA

N-domain of htra1
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
119
structure length
106
Chain Sequence
GCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and Functional Analysis of HtrA1 and Its Subdomains.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Serine protease HTRA1
total genus 23
structure length 106
sequence length 119
ec nomenclature ec 3.4.21.-:
pdb deposition date 2011-08-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00219 IGFBP Insulin-like growth factor binding protein
A PF07648 Kazal_2 Kazal-type serine protease inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 3tjqA00
2N71A 4OVOA 2SGQI 1TUSA 1IY6A 2GKVA 1CT2I 1DS2I 3TJQA 2NU4I 2P6AC 2SGPI 3QTLD 2N52A 1HPTA 1LR8A 2OVOA 1TURA 5DAEA 1PJUA 1SGPI 1YU6C 1R0RI 2GKTI 2QQCA 1CE3A 2NU3I 2KMOA 1OVOA 1YTPA 1PCEA 1TBRR 1TGSI 2BUSA 1SGYI 2KMQA 1UVFA 1M8BA 4HGUA 1H0ZA 2QQDA 1MT1A 3SEKC 2SGEI 1Y1BA 1LR9A 1SGRI 1TBQR 1CHOI 1SGDI 2NU1I 1CSOI 2NU2I 1SGEI 2KMPA 2N17A 1OMTA 2B0UC 2ARPF 1Z7KB 2KCXA 1N13A 1KMAA 1CGJI 3SGQI 4GI3C 1CT0I 1FYBA 2SGDI 2F3CI 1Y1CA 2SGFI 1OMUA 3HH2C 2JZMA 1HDLA 2JXDA 1IW4A 1LR7A 2LEOA 1BUSA 2GKRI 2NU0I 1HJAI 1DS3I 1UVGA 2JYYA 3SGBI 1SGNI 1M8CA 3B4VC 1IY5A 5JHWC 1PPFI 1AN1I 1TIHA 4SGBI 1CT4I 1OYVI 1SGQI 2V53A 2WCYA 2KMRA 2XRCA 3OVOA 1BMOA 2ERWA 1NUBA 1UUCA 2M5XA 1CGII
chains in the Genus database with same CATH superfamily
1KBFA 2V1CA 3OXGA 1XBTA 2N71A 1W3SA 4OVOA 1U5KA 1XX6A 2QPOA 2SGQI 2DIPA 1TBNA 3FSXA 1Z2IA 3D00A 1TUSA 1IY6A 2GKVA 3UEJA 4AMLA 1CT2I 1DS2I 3TJQA 4UXHA 2NU4I 2P6AC 2OZUA 2SGPI 3TO9A 5FUWA 3QTLD 2N52A 1HPTA 2RIJA 1LR8A 2OVOA 1TURA 2L7XA 5DAEA 2CWGA 3R5CA 1PJUA 3UFFA 3R5AA 1SGPI 1WGCA 2RC4A 1YU6C 1R0RI 2GKTI 2QQCA 7WGAA 1CE3A 2NU3I 2GVIA 1ULNA 5HI7A 2KMOA 1V1HA 1OVOA 1YTPA 3OXLA 3PDNA 3VDPA 1PCEA 1NXUA 1TBRR 3QWPA 1TGSI 2B8TA 2BUSA 1SGYI 1FY7A 2ENZA 2KMQA 2CWHA 2UZ3A 1UVFA 1M8BA 3KY9A 4HGUA 5E3RA 2QQDA 3MEKA 3TOAA 1H0ZA 1MT1A 2ORWA 3SEKC 2SGEI 2ODDA 3R5BA 1Y1BA 4A24A 1X74A 2V1CC 1LR9A 1SGRI 3VDUA 5J8FA 2CWFA 1RFHA 2W0TA 1P9ZA 1TBQR 1CHOI 1X4SA 1SGDI 1K7UA 2CJSC 3UGLA 1MJAA 5J8CA 2ROWA 2X52A 5EX0A 1FAQA 2NU1I 3FSYA 4MPIA 2K9HA 1CSOI 2NU2I 1WGTA 3OL0A 2ELIA 1SGEI 2KMPA 5FUXA 2N17A 5FUVA 2FNFX 1OMTA 2YUUA 2E73A 3VE5A 2B0UC 2A20A 2ARPF 3TO6A 1Z7KB 2KCXA 2X3TA 3BJIA 5E3QA 1HEVA 5EX3A 3R5DA 1N13A 2DKVA 3GOXA 1V1IA 2J9RA 1CGJI 1PTRA 1ULMA 2WGCA 3RU0A 3SGQI 1KMAA 4DNCA 4GI3C 4L9MA 1K7VA 1CT0I 2LB7A 1P9GA 4FKDA 2JA1A 3TO7A 3UOEA 1FYBA 1R79A 1UHAA 2SGDI 2F3CI 1Y1CA 4JCVE 5FUYA 1Y8FA 2SGFI 2J87A 1OMUA 2DB6A 1KBEA 5CCMA 1Q9BA 2JZMA 2GIVA 3HH2C 3UEYA 2JXDA 1HDLA 1WTJA 2ORVA 3QAHA 5E3PA 2OU2A 5HQ8A 1IW4A 1LR7A 1TOTA 4B6DA 1FARA 2VRWB 2LEOA 3TOBA 1BUSA 2GKRI 2N1AB 2NU0I 1S20A 1HJAI 1DS3I 1UVGA 2JYYA 3SGBI 1SGNI 4UXJA 1M8CA 2YQPA 1PTQA 3B4VC 2OD1A 1IY5A 5CCLA 1WKXA 4WP4A 3CXLA 1TBOA 1VDDA 2WVJA 1W4RA 2ENNA 3UGIA 5JHWC 1PPFI 1AN1I 1TIHA 2L8EA 3E2IA 2UVOA 9WGAA 4SGBI 2PQ8A 1CT4I 2Y0MA 1ULKA 1XA6A 1OYVI 1SGQI 2V53A 2E5RA 2JW6A 1MJ9A 2WCYA 2LUYA 2KMRA 3E59A 1K7TA 2XRCA 3OVOA 4E1PA 2QQ0A 1BMOA 3OXFA 3FC3A 2ERWA 1NUBA 3UGDA 4E1RA 4UXIA 1MJBA 1UUCA 2M5XA 1CGII 2QQEA
chains in the Genus database with same CATH topology
1KBFA 2V1CA 3OXGA 1XBTA 2N71A 1W3SA 4OVOA 1U5KA 1XX6A 2QPOA 2SGQI 2DIPA 1TBNA 3D00A 1TUSA 1IY6A 2GKVA 3UEJA 1CT2I 1DS2I 3TJQA 4UXHA 2NU4I 2P6AC 2SGPI 5FUWA 3QTLD 2N52A 1HPTA 1LR8A 2OVOA 1TURA 2L7XA 5DAEA 1PJUA 3UFFA 1SGPI 1YU6C 1R0RI 2GKTI 2QQCA 1CE3A 2NU3I 2GVIA 5HI7A 2KMOA 1V1HA 1OVOA 1YTPA 3OXLA 3PDNA 3VDPA 1PCEA 1TBRR 3QWPA 1TGSI 2B8TA 2BUSA 1SGYI 2UZ3A 2ENZA 2KMQA 1UVFA 1M8BA 3KY9A 4HGUA 1H0ZA 2QQDA 3MEKA 1MT1A 2ORWA 3SEKC 2SGEI 2ODDA 1Y1BA 4A24A 1X74A 2V1CC 1LR9A 1SGRI 3VDUA 1RFHA 2W0TA 1TBQR 1CHOI 1X4SA 1SGDI 2CJSC 3UGLA 1FAQA 2ROWA 5EX0A 2NU1I 2K9HA 1CSOI 2NU2I 3OL0A 2ELIA 1SGEI 2KMPA 5FUXA 2N17A 5FUVA 2FNFX 1OMTA 2YUUA 2E73A 3VE5A 2B0UC 2A20A 2ARPF 1Z7KB 2KCXA 3BJIA 5EX3A 1N13A 3GOXA 1V1IA 2J9RA 1CGJI 1PTRA 3RU0A 3SGQI 1KMAA 4GI3C 4L9MA 1CT0I 1FYBA 4FKDA 2JA1A 1R79A 2SGDI 2F3CI 1Y1CA 4JCVE 5FUYA 1Y8FA 2SGFI 2J87A 1OMUA 2DB6A 1KBEA 5CCMA 3HH2C 2JZMA 3UEYA 1HDLA 2JXDA 2ORVA 5HQ8A 1IW4A 1LR7A 1TOTA 4B6DA 1FARA 2VRWB 2LEOA 1BUSA 2GKRI 2N1AB 2NU0I 1HJAI 1DS3I 1UVGA 2JYYA 3SGBI 1SGNI 4UXJA 1M8CA 2YQPA 1PTQA 3B4VC 2OD1A 1IY5A 5CCLA 3CXLA 1TBOA 1VDDA 2WVJA 1W4RA 2ENNA 3UGIA 5JHWC 1PPFI 1AN1I 1TIHA 2L8EA 3E2IA 4SGBI 1CT4I 1XA6A 1OYVI 1SGQI 2V53A 2E5RA 2JW6A 3E59A 2WCYA 2LUYA 2KMRA 2XRCA 3OVOA 4E1PA 2QQ0A 1BMOA 3OXFA 3FC3A 2ERWA 1NUBA 3UGDA 4E1RA 4UXIA 1UUCA 2M5XA 1CGII 2QQEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2N71 A;  4OVO A;  2SGQ I;  1TUS A;  1IY6 A;  2GKV A;  1CT2 I;  1DS2 I;  3TJQ A;  2NU4 I;  2P6A C;  2SGP I;  3QTL D;  2N52 A;  1HPT A;  1LR8 A;  2OVO A;  1TUR A;  5DAE A;  1PJU A;  1SGP I;  1YU6 C;  1R0R I;  2GKT I;  2QQC A;  1CE3 A;  2NU3 I;  2KMO A;  1OVO A;  1YTP A;  1PCE A;  1TBR R;  1TGS I;  2BUS A;  1SGY I;  2KMQ A;  1UVF A;  1M8B A;  4HGU A;  1H0Z A;  2QQD A;  1MT1 A;  3SEK C;  2SGE I;  1Y1B A;  1LR9 A;  1SGR I;  1TBQ R;  1CHO I;  1SGD I;  2NU1 I;  1CSO I;  2NU2 I;  1SGE I;  2KMP A;  2N17 A;  1OMT A;  2B0U C;  2ARP F;  1Z7K B;  2KCX A;  1N13 A;  1KMA A;  1CGJ I;  3SGQ I;  4GI3 C;  1CT0 I;  1FYB A;  2SGD I;  2F3C I;  1Y1C A;  2SGF I;  1OMU A;  3HH2 C;  2JZM A;  1HDL A;  2JXD A;  1IW4 A;  1LR7 A;  2LEO A;  1BUS A;  2GKR I;  2NU0 I;  1HJA I;  1DS3 I;  1UVG A;  2JYY A;  3SGB I;  1SGN I;  1M8C A;  3B4V C;  1IY5 A;  5JHW C;  1PPF I;  1AN1 I;  1TIH A;  4SGB I;  1CT4 I;  1OYV I;  1SGQ I;  2V53 A;  2WCY A;  2KMR A;  2XRC A;  3OVO A;  1BMO A;  2ERW A;  1NUB A;  1UUC A;  2M5X A;  1CGI I; 
#chains in the Genus database with same CATH topology
 1KBF A;  2V1C A;  3OXG A;  1XBT A;  2N71 A;  1W3S A;  4OVO A;  1U5K A;  1XX6 A;  2QPO A;  2SGQ I;  2DIP A;  1TBN A;  3FSX A;  1Z2I A;  3D00 A;  1TUS A;  1IY6 A;  2GKV A;  3UEJ A;  4AML A;  1CT2 I;  1DS2 I;  3TJQ A;  4UXH A;  2NU4 I;  2P6A C;  2OZU A;  2SGP I;  3TO9 A;  5FUW A;  3QTL D;  2N52 A;  1HPT A;  2RIJ A;  1LR8 A;  2OVO A;  1TUR A;  2L7X A;  5DAE A;  2CWG A;  3R5C A;  1PJU A;  3UFF A;  3R5A A;  1SGP I;  1WGC A;  2RC4 A;  1YU6 C;  1R0R I;  2GKT I;  2QQC A;  7WGA A;  1CE3 A;  2NU3 I;  2GVI A;  1ULN A;  5HI7 A;  2KMO A;  1V1H A;  1OVO A;  1YTP A;  3OXL A;  3PDN A;  3VDP A;  1PCE A;  1NXU A;  1TBR R;  3QWP A;  1TGS I;  2B8T A;  2BUS A;  1SGY I;  1FY7 A;  2ENZ A;  2KMQ A;  2CWH A;  2UZ3 A;  1UVF A;  1M8B A;  3KY9 A;  4HGU A;  5E3R A;  2QQD A;  3MEK A;  3TOA A;  1H0Z A;  1MT1 A;  2ORW A;  3SEK C;  2SGE I;  2ODD A;  3R5B A;  1Y1B A;  4A24 A;  1X74 A;  2V1C C;  1LR9 A;  1SGR I;  3VDU A;  5J8F A;  2CWF A;  1RFH A;  2W0T A;  1P9Z A;  1TBQ R;  1CHO I;  1X4S A;  1SGD I;  1K7U A;  2CJS C;  3UGL A;  1MJA A;  5J8C A;  2ROW A;  2X52 A;  5EX0 A;  1FAQ A;  2NU1 I;  3FSY A;  4MPI A;  2K9H A;  1CSO I;  2NU2 I;  1WGT A;  3OL0 A;  2ELI A;  1SGE I;  2KMP A;  5FUX A;  2N17 A;  5FUV A;  2FNF X;  1OMT A;  2YUU A;  2E73 A;  3VE5 A;  2B0U C;  2A20 A;  2ARP F;  3TO6 A;  1Z7K B;  2KCX A;  2X3T A;  3BJI A;  5E3Q A;  1HEV A;  5EX3 A;  3R5D A;  1N13 A;  2DKV A;  3GOX A;  1V1I A;  2J9R A;  1CGJ I;  1PTR A;  1ULM A;  2WGC A;  3RU0 A;  3SGQ I;  1KMA A;  4DNC A;  4GI3 C;  4L9M A;  1K7V A;  1CT0 I;  2LB7 A;  1P9G A;  4FKD A;  2JA1 A;  3TO7 A;  3UOE A;  1FYB A;  1R79 A;  1UHA A;  2SGD I;  2F3C I;  1Y1C A;  4JCV E;  5FUY A;  1Y8F A;  2SGF I;  2J87 A;  1OMU A;  2DB6 A;  1KBE A;  5CCM A;  1Q9B A;  2JZM A;  2GIV A;  3HH2 C;  3UEY A;  2JXD A;  1HDL A;  1WTJ A;  2ORV A;  3QAH A;  5E3P A;  2OU2 A;  5HQ8 A;  1IW4 A;  1LR7 A;  1TOT A;  4B6D A;  1FAR A;  2VRW B;  2LEO A;  3TOB A;  1BUS A;  2GKR I;  2N1A B;  2NU0 I;  1S20 A;  1HJA I;  1DS3 I;  1UVG A;  2JYY A;  3SGB I;  1SGN I;  4UXJ A;  1M8C A;  2YQP A;  1PTQ A;  3B4V C;  2OD1 A;  1IY5 A;  5CCL A;  1WKX A;  4WP4 A;  3CXL A;  1TBO A;  1VDD A;  2WVJ A;  1W4R A;  2ENN A;  3UGI A;  5JHW C;  1PPF I;  1AN1 I;  1TIH A;  2L8E A;  3E2I A;  2UVO A;  9WGA A;  4SGB I;  2PQ8 A;  1CT4 I;  2Y0M A;  1ULK A;  1XA6 A;  1OYV I;  1SGQ I;  2V53 A;  2E5R A;  2JW6 A;  1MJ9 A;  2WCY A;  2LUY A;  2KMR A;  3E59 A;  1K7T A;  2XRC A;  3OVO A;  4E1P A;  2QQ0 A;  1BMO A;  3OXF A;  3FC3 A;  2ERW A;  1NUB A;  3UGD A;  4E1R A;  4UXI A;  1MJB A;  1UUC A;  2M5X A;  1CGI I;  2QQE A; 
#chains in the Genus database with same CATH homology
 1KBF A;  2V1C A;  3OXG A;  1XBT A;  2N71 A;  1W3S A;  4OVO A;  1U5K A;  1XX6 A;  2QPO A;  2SGQ I;  2DIP A;  1TBN A;  3D00 A;  1TUS A;  1IY6 A;  2GKV A;  3UEJ A;  1CT2 I;  1DS2 I;  3TJQ A;  4UXH A;  2NU4 I;  2P6A C;  2SGP I;  5FUW A;  3QTL D;  2N52 A;  1HPT A;  1LR8 A;  2OVO A;  1TUR A;  2L7X A;  5DAE A;  1PJU A;  3UFF A;  1SGP I;  1YU6 C;  1R0R I;  2GKT I;  2QQC A;  1CE3 A;  2NU3 I;  2GVI A;  5HI7 A;  2KMO A;  1V1H A;  1OVO A;  1YTP A;  3OXL A;  3PDN A;  3VDP A;  1PCE A;  1TBR R;  3QWP A;  1TGS I;  2B8T A;  2BUS A;  1SGY I;  2UZ3 A;  2ENZ A;  2KMQ A;  1UVF A;  1M8B A;  3KY9 A;  4HGU A;  1H0Z A;  2QQD A;  3MEK A;  1MT1 A;  2ORW A;  3SEK C;  2SGE I;  2ODD A;  1Y1B A;  4A24 A;  1X74 A;  2V1C C;  1LR9 A;  1SGR I;  3VDU A;  1RFH A;  2W0T A;  1TBQ R;  1CHO I;  1X4S A;  1SGD I;  2CJS C;  3UGL A;  1FAQ A;  2ROW A;  5EX0 A;  2NU1 I;  2K9H A;  1CSO I;  2NU2 I;  3OL0 A;  2ELI A;  1SGE I;  2KMP A;  5FUX A;  2N17 A;  5FUV A;  2FNF X;  1OMT A;  2YUU A;  2E73 A;  3VE5 A;  2B0U C;  2A20 A;  2ARP F;  1Z7K B;  2KCX A;  3BJI A;  5EX3 A;  1N13 A;  3GOX A;  1V1I A;  2J9R A;  1CGJ I;  1PTR A;  3RU0 A;  3SGQ I;  1KMA A;  4GI3 C;  4L9M A;  1CT0 I;  1FYB A;  4FKD A;  2JA1 A;  1R79 A;  2SGD I;  2F3C I;  1Y1C A;  4JCV E;  5FUY A;  1Y8F A;  2SGF I;  2J87 A;  1OMU A;  2DB6 A;  1KBE A;  5CCM A;  3HH2 C;  2JZM A;  3UEY A;  1HDL A;  2JXD A;  2ORV A;  5HQ8 A;  1IW4 A;  1LR7 A;  1TOT A;  4B6D A;  1FAR A;  2VRW B;  2LEO A;  1BUS A;  2GKR I;  2N1A B;  2NU0 I;  1HJA I;  1DS3 I;  1UVG A;  2JYY A;  3SGB I;  1SGN I;  4UXJ A;  1M8C A;  2YQP A;  1PTQ A;  3B4V C;  2OD1 A;  1IY5 A;  5CCL A;  3CXL A;  1TBO A;  1VDD A;  2WVJ A;  1W4R A;  2ENN A;  3UGI A;  5JHW C;  1PPF I;  1AN1 I;  1TIH A;  2L8E A;  3E2I A;  4SGB I;  1CT4 I;  1XA6 A;  1OYV I;  1SGQ I;  2V53 A;  2E5R A;  2JW6 A;  3E59 A;  2WCY A;  2LUY A;  2KMR A;  2XRC A;  3OVO A;  4E1P A;  2QQ0 A;  1BMO A;  3OXF A;  3FC3 A;  2ERW A;  1NUB A;  3UGD A;  4E1R A;  4UXI A;  1UUC A;  2M5X A;  1CGI I;  2QQE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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