3UGIA

Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase c delta
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
65
structure length
65
Chain Sequence
GSRRASVGSHRFKVYNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCEFIVTD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural and Functional Characterization of an Anesthetic Binding Site in the Second Cysteine-Rich Domain of Protein Kinase Cdelta
pubmed doi rcsb
molecule tags Metal binding protein
source organism Mus musculus
molecule keywords Protein kinase C delta type
total genus 11
structure length 65
sequence length 65
chains with identical sequence B
ec nomenclature ec 2.7.10.2: Non-specific protein-tyrosine kinase.
pdb deposition date 2011-11-02
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.20 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 3ugiA01
1RFHA 4UXHA 2QPOA 4UXJA 2J9RA 3UGDA 4UXIA 3CXLA 4B6DA 1PTQA 2QQ0A 2GVIA 2J87A 2WVJA 1KBEA 3BJIA 1Y8FA 4L9MA 3UFFA 2E73A 1TBOA 2ENNA 2FNFX 2QQEA 2YUUA 2DB6A 1TBNA 3E2IA 3KY9A 1XBTA 2VRWB 5FUXA 3UGIA 5FUVA 2B8TA 2UZ3A 1XA6A 2ROWA 2JA1A 1W4RA 2ORWA 2ELIA 5FUWA 2ENZA 1R79A 5FUYA 1FAQA 1KBFA 1PTRA 4FKDA 3UEJA 1FARA 3UGLA 1XX6A 2ORVA 3UEYA
chains in the Genus database with same CATH superfamily
2L8EA 5E3PA 4A24A 4UXHA 4WP4A 3VE5A 1H0ZA 1TBQR 4JCVE 4E1RA 4UXJA 2GKTI 1UVGA 3FSXA 3PDNA 2OVOA 2E5RA 1Z2IA 4UXIA 1ULKA 3UGDA 3VDPA 2GKRI 2QQ0A 1CSOI 1M8CA 2GVIA 2JYYA 4GI3C 1SGRI 4L9MA 1S20A 1AN1I 1V1HA 2GIVA 2SGEI 3QAHA 1PPFI 3SGQI 2CJSC 2QQEA 2YUUA 3R5BA 1SGNI 2JXDA 2N71A 4HGUA 4DNCA 2QQCA 2KMRA 5FUVA 2ROWA 1PCEA 1V1IA 1ULMA 1W4RA 2JA1A 2SGFI 1HEVA 3TJQA 2ELIA 4E1PA 2ENZA 2N17A 1WGCA 2JW6A 1K7UA 1P9GA 2A20A 4FKDA 2KCXA 1XX6A 2UVOA 4AMLA 1CGJI 1N13A 1OMTA 3HH2C 1SGYI 1CE3A 2LB7A 2QPOA 1Y1CA 1IY6A 1LR8A 2KMPA 3MEKA 5JHWC 1UVFA 1WGTA 2GKVA 2SGQI 2N1AB 3R5AA 1TBRR 4SGBI 1BUSA 2PQ8A 1OVOA 1R0RI 3R5DA 1TBOA 2FNFX 1PJUA 3TOBA 5CCMA 3SEKC 1MJ9A 1OMUA 1TBNA 2CWHA 2M5XA 1MJAA 2VRWB 2SGDI 1XA6A 2DIPA 2WCYA 3TO7A 2V53A 2LUYA 3OXLA 1SGEI 2L7XA 3UFFA 1UUCA 1M8BA 1TIHA 3OXGA 3UOEA 1FYBA 2NU3I 1HDLA 1FAQA 1KBFA 3D00A 1MJBA 1TOTA 1Y1BA 1NXUA 1PTRA 1YTPA 3UGLA 1TURA 2ORVA 2OU2A 1X4SA 2OD1A 1RFHA 1CT2I 1SGDI 1Q9BA 1CT4I 1ULNA 2OZUA 4MPIA 1CT0I 1UHAA 2QQDA 2J9RA 5E3QA 1VDDA 2W0TA 1WTJA 1W3SA 4B6DA 3FC3A 2NU0I 2B0UC 2J87A 3R5CA 3E59A 1CGII 1DS2I 4OVOA 2V1CC 2DKVA 2E73A 3VDUA 2P6AC 2NU4I 3B4VC 3GOXA 2F3CI 5DAEA 1P9ZA 2K9HA 3KY9A 3E2IA 2DB6A 1U5KA 1DS3I 3UGIA 2Y0MA 1IY5A 2UZ3A 5E3RA 1WKXA 2N52A 2KMOA 5FUWA 1LR7A 2JZMA 1X74A 1SGQI 5CCLA 1HPTA 5FUYA 9WGAA 5EX3A 2X52A 2NU2I 2ERWA 1NUBA 2NU1I 1YU6C 7WGAA 1Z7KB 1SGPI 2KMQA 1FY7A 2SGPI 5HI7A 3TOAA 2RC4A 1OYVI 2WGCA 5J8FA 1IW4A 1CHOI 3CXLA 5J8CA 3QTLD 1PTQA 2WVJA 2LEOA 3BJIA 1KBEA 3OVOA 1Y8FA 3RU0A 3TO9A 5HQ8A 2XRCA 3OXFA 3TO6A 2ENNA 2ARPF 1LR9A 1TGSI 2V1CA 5FUXA 1XBTA 3OL0A 2CWFA 2B8TA 3SGBI 1MT1A 2ORWA 1TUSA 2X3TA 2CWGA 1KMAA 1R79A 1BMOA 2ODDA 2RIJA 2YQPA 2BUSA 1HJAI 3UEJA 1FARA 1K7TA 1K7VA 3FSYA 3QWPA 5EX0A 3UEYA
chains in the Genus database with same CATH topology
2L8EA 4A24A 4UXHA 1H0ZA 3VE5A 1TBQR 4JCVE 4E1RA 4UXJA 2GKTI 1UVGA 3PDNA 2OVOA 2E5RA 3UGDA 4UXIA 3VDPA 2GKRI 2QQ0A 1CSOI 1M8CA 2GVIA 2JYYA 4GI3C 1SGRI 4L9MA 1V1HA 1AN1I 2SGEI 1PPFI 3SGQI 2CJSC 2QQEA 2YUUA 4HGUA 1SGNI 2JXDA 2N71A 2QQCA 2KMRA 5FUVA 2ROWA 1PCEA 1V1IA 1W4RA 2JA1A 2SGFI 3TJQA 2ELIA 4E1PA 2ENZA 2N17A 2JW6A 2A20A 4FKDA 2KCXA 1XX6A 1CGJI 1N13A 1OMTA 3HH2C 1SGYI 1CE3A 2QPOA 1Y1CA 1IY6A 1LR8A 2KMPA 3MEKA 5JHWC 1UVFA 2GKVA 2SGQI 2N1AB 1TBRR 4SGBI 1BUSA 1OVOA 1R0RI 1TBOA 2FNFX 1PJUA 5CCMA 3SEKC 1OMUA 1TBNA 2M5XA 2VRWB 2SGDI 1XA6A 2DIPA 2WCYA 2V53A 2LUYA 3OXLA 1SGEI 2L7XA 3UFFA 1UUCA 1M8BA 1TIHA 3OXGA 1FYBA 2NU3I 1HDLA 1FAQA 1KBFA 3D00A 1TOTA 1Y1BA 1PTRA 1YTPA 3UGLA 1TURA 2ORVA 1X4SA 2OD1A 1RFHA 1CT2I 1SGDI 1CT4I 1CT0I 2QQDA 2J9RA 1VDDA 2W0TA 1W3SA 4B6DA 3FC3A 2NU0I 2B0UC 2J87A 4OVOA 3E59A 1CGII 1DS2I 2V1CC 3VDUA 2E73A 2P6AC 2NU4I 3B4VC 3GOXA 2F3CI 5DAEA 2K9HA 3KY9A 3E2IA 2DB6A 1U5KA 1DS3I 3UGIA 1IY5A 2UZ3A 2N52A 2KMOA 5FUWA 1LR7A 2JZMA 1X74A 1SGQI 5CCLA 1HPTA 5FUYA 5EX3A 2NU2I 2ERWA 1NUBA 2NU1I 1YU6C 1Z7KB 1SGPI 2KMQA 2SGPI 5HI7A 1OYVI 1IW4A 1CHOI 3CXLA 3QTLD 1PTQA 2WVJA 2LEOA 3BJIA 1KBEA 3OVOA 1Y8FA 3RU0A 5HQ8A 2XRCA 3OXFA 2ENNA 2ARPF 1LR9A 1TGSI 2V1CA 5FUXA 1XBTA 3OL0A 2B8TA 3SGBI 1MT1A 2ORWA 1TUSA 1KMAA 1R79A 1BMOA 2ODDA 2YQPA 2BUSA 1HJAI 3UEJA 1FARA 3QWPA 5EX0A 3UEYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RFH A;  4UXH A;  2QPO A;  4UXJ A;  2J9R A;  3UGD A;  4UXI A;  3CXL A;  4B6D A;  1PTQ A;  2QQ0 A;  2GVI A;  2J87 A;  2WVJ A;  1KBE A;  3BJI A;  1Y8F A;  4L9M A;  3UFF A;  2E73 A;  1TBO A;  2ENN A;  2FNF X;  2QQE A;  2YUU A;  2DB6 A;  1TBN A;  3E2I A;  3KY9 A;  1XBT A;  2VRW B;  5FUX A;  3UGI A;  5FUV A;  2B8T A;  2UZ3 A;  1XA6 A;  2ROW A;  2JA1 A;  1W4R A;  2ORW A;  2ELI A;  5FUW A;  2ENZ A;  1R79 A;  5FUY A;  1FAQ A;  1KBF A;  1PTR A;  4FKD A;  3UEJ A;  1FAR A;  3UGL A;  1XX6 A;  2ORV A;  3UEY A; 
#chains in the Genus database with same CATH topology
 2L8E A;  5E3P A;  4A24 A;  4UXH A;  4WP4 A;  3VE5 A;  1H0Z A;  1TBQ R;  4JCV E;  4E1R A;  4UXJ A;  2GKT I;  1UVG A;  3FSX A;  3PDN A;  2OVO A;  2E5R A;  1Z2I A;  4UXI A;  1ULK A;  3UGD A;  3VDP A;  2GKR I;  2QQ0 A;  1CSO I;  1M8C A;  2GVI A;  2JYY A;  4GI3 C;  1SGR I;  4L9M A;  1S20 A;  1AN1 I;  1V1H A;  2GIV A;  2SGE I;  3QAH A;  1PPF I;  3SGQ I;  2CJS C;  2QQE A;  2YUU A;  3R5B A;  1SGN I;  2JXD A;  2N71 A;  4HGU A;  4DNC A;  2QQC A;  2KMR A;  5FUV A;  2ROW A;  1PCE A;  1V1I A;  1ULM A;  1W4R A;  2JA1 A;  2SGF I;  1HEV A;  3TJQ A;  2ELI A;  4E1P A;  2ENZ A;  2N17 A;  1WGC A;  2JW6 A;  1K7U A;  1P9G A;  2A20 A;  4FKD A;  2KCX A;  1XX6 A;  2UVO A;  4AML A;  1CGJ I;  1N13 A;  1OMT A;  3HH2 C;  1SGY I;  1CE3 A;  2LB7 A;  2QPO A;  1Y1C A;  1IY6 A;  1LR8 A;  2KMP A;  3MEK A;  5JHW C;  1UVF A;  1WGT A;  2GKV A;  2SGQ I;  2N1A B;  3R5A A;  1TBR R;  4SGB I;  1BUS A;  2PQ8 A;  1OVO A;  1R0R I;  3R5D A;  1TBO A;  2FNF X;  1PJU A;  3TOB A;  5CCM A;  3SEK C;  1MJ9 A;  1OMU A;  1TBN A;  2CWH A;  2M5X A;  1MJA A;  2VRW B;  2SGD I;  1XA6 A;  2DIP A;  2WCY A;  3TO7 A;  2V53 A;  2LUY A;  3OXL A;  1SGE I;  2L7X A;  3UFF A;  1UUC A;  1M8B A;  1TIH A;  3OXG A;  3UOE A;  1FYB A;  2NU3 I;  1HDL A;  1FAQ A;  1KBF A;  3D00 A;  1MJB A;  1TOT A;  1Y1B A;  1NXU A;  1PTR A;  1YTP A;  3UGL A;  1TUR A;  2ORV A;  2OU2 A;  1X4S A;  2OD1 A;  1RFH A;  1CT2 I;  1SGD I;  1Q9B A;  1CT4 I;  1ULN A;  2OZU A;  4MPI A;  1CT0 I;  1UHA A;  2QQD A;  2J9R A;  5E3Q A;  1VDD A;  2W0T A;  1WTJ A;  1W3S A;  4B6D A;  3FC3 A;  2NU0 I;  2B0U C;  2J87 A;  3R5C A;  3E59 A;  1CGI I;  1DS2 I;  4OVO A;  2V1C C;  2DKV A;  2E73 A;  3VDU A;  2P6A C;  2NU4 I;  3B4V C;  3GOX A;  2F3C I;  5DAE A;  1P9Z A;  2K9H A;  3KY9 A;  3E2I A;  2DB6 A;  1U5K A;  1DS3 I;  3UGI A;  2Y0M A;  1IY5 A;  2UZ3 A;  5E3R A;  1WKX A;  2N52 A;  2KMO A;  5FUW A;  1LR7 A;  2JZM A;  1X74 A;  1SGQ I;  5CCL A;  1HPT A;  5FUY A;  9WGA A;  5EX3 A;  2X52 A;  2NU2 I;  2ERW A;  1NUB A;  2NU1 I;  1YU6 C;  7WGA A;  1Z7K B;  1SGP I;  2KMQ A;  1FY7 A;  2SGP I;  5HI7 A;  3TOA A;  2RC4 A;  1OYV I;  2WGC A;  5J8F A;  1IW4 A;  1CHO I;  3CXL A;  5J8C A;  3QTL D;  1PTQ A;  2WVJ A;  2LEO A;  3BJI A;  1KBE A;  3OVO A;  1Y8F A;  3RU0 A;  3TO9 A;  5HQ8 A;  2XRC A;  3OXF A;  3TO6 A;  2ENN A;  2ARP F;  1LR9 A;  1TGS I;  2V1C A;  5FUX A;  1XBT A;  3OL0 A;  2CWF A;  2B8T A;  3SGB I;  1MT1 A;  2ORW A;  1TUS A;  2X3T A;  2CWG A;  1KMA A;  1R79 A;  1BMO A;  2ODD A;  2RIJ A;  2YQP A;  2BUS A;  1HJA I;  3UEJ A;  1FAR A;  1K7T A;  1K7V A;  3FSY A;  3QWP A;  5EX0 A;  3UEY A; 
#chains in the Genus database with same CATH homology
 2L8E A;  4A24 A;  4UXH A;  1H0Z A;  3VE5 A;  1TBQ R;  4JCV E;  4E1R A;  4UXJ A;  2GKT I;  1UVG A;  3PDN A;  2OVO A;  2E5R A;  3UGD A;  4UXI A;  3VDP A;  2GKR I;  2QQ0 A;  1CSO I;  1M8C A;  2GVI A;  2JYY A;  4GI3 C;  1SGR I;  4L9M A;  1V1H A;  1AN1 I;  2SGE I;  1PPF I;  3SGQ I;  2CJS C;  2QQE A;  2YUU A;  4HGU A;  1SGN I;  2JXD A;  2N71 A;  2QQC A;  2KMR A;  5FUV A;  2ROW A;  1PCE A;  1V1I A;  1W4R A;  2JA1 A;  2SGF I;  3TJQ A;  2ELI A;  4E1P A;  2ENZ A;  2N17 A;  2JW6 A;  2A20 A;  4FKD A;  2KCX A;  1XX6 A;  1CGJ I;  1N13 A;  1OMT A;  3HH2 C;  1SGY I;  1CE3 A;  2QPO A;  1Y1C A;  1IY6 A;  1LR8 A;  2KMP A;  3MEK A;  5JHW C;  1UVF A;  2GKV A;  2SGQ I;  2N1A B;  1TBR R;  4SGB I;  1BUS A;  1OVO A;  1R0R I;  1TBO A;  2FNF X;  1PJU A;  5CCM A;  3SEK C;  1OMU A;  1TBN A;  2M5X A;  2VRW B;  2SGD I;  1XA6 A;  2DIP A;  2WCY A;  2V53 A;  2LUY A;  3OXL A;  1SGE I;  2L7X A;  3UFF A;  1UUC A;  1M8B A;  1TIH A;  3OXG A;  1FYB A;  2NU3 I;  1HDL A;  1FAQ A;  1KBF A;  3D00 A;  1TOT A;  1Y1B A;  1PTR A;  1YTP A;  3UGL A;  1TUR A;  2ORV A;  1X4S A;  2OD1 A;  1RFH A;  1CT2 I;  1SGD I;  1CT4 I;  1CT0 I;  2QQD A;  2J9R A;  1VDD A;  2W0T A;  1W3S A;  4B6D A;  3FC3 A;  2NU0 I;  2B0U C;  2J87 A;  4OVO A;  3E59 A;  1CGI I;  1DS2 I;  2V1C C;  3VDU A;  2E73 A;  2P6A C;  2NU4 I;  3B4V C;  3GOX A;  2F3C I;  5DAE A;  2K9H A;  3KY9 A;  3E2I A;  2DB6 A;  1U5K A;  1DS3 I;  3UGI A;  1IY5 A;  2UZ3 A;  2N52 A;  2KMO A;  5FUW A;  1LR7 A;  2JZM A;  1X74 A;  1SGQ I;  5CCL A;  1HPT A;  5FUY A;  5EX3 A;  2NU2 I;  2ERW A;  1NUB A;  2NU1 I;  1YU6 C;  1Z7K B;  1SGP I;  2KMQ A;  2SGP I;  5HI7 A;  1OYV I;  1IW4 A;  1CHO I;  3CXL A;  3QTL D;  1PTQ A;  2WVJ A;  2LEO A;  3BJI A;  1KBE A;  3OVO A;  1Y8F A;  3RU0 A;  5HQ8 A;  2XRC A;  3OXF A;  2ENN A;  2ARP F;  1LR9 A;  1TGS I;  2V1C A;  5FUX A;  1XBT A;  3OL0 A;  2B8T A;  3SGB I;  1MT1 A;  2ORW A;  1TUS A;  1KMA A;  1R79 A;  1BMO A;  2ODD A;  2YQP A;  2BUS A;  1HJA I;  3UEJ A;  1FAR A;  3QWP A;  5EX0 A;  3UEY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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