3QTLD

Structural basis for dual-inhibition mechanism of a non-classical kazal-type serine protease inhibitor from horseshoe crab in complex with subtilisin
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
75
structure length
75
Chain Sequence
APCPHTYKPVCGANGEVYDNECFLNKAGIEPAESWETCRGHELCPSVCTEEYDPVCVEGKIYGNRCMQSHFCGKV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for dual-inhibition mechanism of a non-classical kazal-type serine protease inhibitor from horseshoe crab in complex with subtilisin.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Bacillus licheniformis
molecule keywords Subtilisin-like serin protease
total genus 9
structure length 75
sequence length 75
ec nomenclature
pdb deposition date 2011-02-23
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 3qtlD00
1PCEA 2SGFI 2GKRI 3QTLD 2BUSA 2SGPI 1PJUA 1YTPA 4SGBI 1HPTA 1OVOA 1Y1BA 2QQCA 1YU6C 1MT1A 2N17A 2M5XA 2NU3I 2V53A 1N13A 2N52A 2KMPA 5DAEA 1PPFI 3SGBI 1CHOI 1OYVI 1Z7KB 2KCXA 2LEOA 1IW4A 1SGRI 1LR7A 1IY6A 2OVOA 1OMTA 2ERWA 2SGEI 2N71A 2WCYA 2KMQA 2NU1I 1HDLA 1CSOI 3TJQA 1DS2I 1TBRR 1H0ZA 3OVOA 1SGEI 3SGQI 1UUCA 5JHWC 1TBQR 4GI3C 1NUBA 2NU2I 2KMRA 4OVOA 1TURA 1LR9A 1TGSI 2P6AC 2GKVA 1TUSA 1CT4I 1CE3A 2JYYA 1FYBA 1SGYI 1CT0I 1LR8A 1R0RI 1CGII 2QQDA 2XRCA 3B4VC 1SGPI 1BUSA 1CGJI 3HH2C 1SGNI 1IY5A 1M8BA 1AN1I 4HGUA 2ARPF 1BMOA 1CT2I 2JZMA 1M8CA 2SGDI 1KMAA 1Y1CA 2NU0I 2GKTI 2NU4I 1TIHA 2KMOA 1SGDI 3SEKC 2F3CI 2B0UC 2JXDA 1HJAI 1UVGA 1SGQI 1UVFA 2SGQI 1DS3I 1OMUA
chains in the Genus database with same CATH superfamily
1PCEA 2V1CA 2SGFI 2GKRI 3QTLD 3TO6A 1MJAA 4WP4A 1Q9BA 1WGCA 2BUSA 2SGPI 3UEJA 1TBOA 1PJUA 2Y0MA 5E3QA 1PTQA 2DB6A 2DIPA 5FUXA 1YTPA 1ULKA 4SGBI 1HPTA 1OVOA 1K7TA 1Y1BA 3QWPA 2X52A 3D00A 3UEYA 5FUYA 2QQCA 1YU6C 1MT1A 2N17A 3E2IA 5E3PA 3VDUA 3TO7A 3OL0A 1S20A 2L7XA 2W0TA 1U5KA 2M5XA 2NU3I 5CCMA 2V53A 2CJSC 2VRWB 2DKVA 1N13A 2N52A 4A24A 2KMPA 2OD1A 2UVOA 3MEKA 5DAEA 1PPFI 1Z2IA 3R5CA 1CHOI 3SGBI 1OYVI 1XBTA 4UXIA 5HI7A 1Z7KB 1DS3I 1FAQA 2KCXA 2LEOA 2QQEA 1IW4A 1VDDA 2QQ0A 1SGRI 3FSYA 1LR7A 4UXHA 2OVOA 1OMTA 3UGDA 1IY6A 2ERWA 1RFHA 1W4RA 2SGEI 2N71A 2WCYA 3E59A 2KMQA 1P9GA 4MPIA 3TOBA 4AMLA 1P9ZA 2NU1I 1HDLA 3BJIA 1K7UA 2LUYA 5FUVA 5CCLA 1CSOI 1V1HA 2L8EA 3FSXA 3TJQA 2A20A 1DS2I 1TBRR 3R5BA 2WGCA 4B6DA 1KBEA 2YQPA 5FUWA 1H0ZA 3OVOA 1SGEI 3UGIA 3UOEA 3SGQI 1UUCA 1XA6A 5HQ8A 5JHWC 3VDPA 2OU2A 1TBQR 1FY7A 2RC4A 2CWGA 4GI3C 3FC3A 2CWFA 2JA1A 1NUBA 2N1AB 2YUUA 3PDNA 5EX3A 2NU2I 2KMRA 4OVOA 5EX0A 2K9HA 2ROWA 2E5RA 1TURA 2QPOA 1LR9A 2JW6A 1TGSI 2WVJA 3RU0A 4FKDA 3OXLA 2P6AC 3UFFA 2GKVA 4E1RA 2GIVA 1TUSA 2E73A 1TOTA 9WGAA 3TOAA 1CT4I 4L9MA 2JYYA 2X3TA 1CE3A 1SGYI 1CT0I 1FYBA 3VE5A 1LR8A 2ORVA 1R0RI 4JCVE 3TO9A 1ULMA 2OZUA 1CGII 2QQDA 5E3RA 1ULNA 2J87A 1X4SA 2XRCA 3B4VC 1SGPI 1BUSA 1CGJI 1V1IA 1WTJA 2GVIA 1SGNI 2RIJA 2UZ3A 3HH2C 2ORWA 1NXUA 1FARA 2PQ8A 3OXFA 3QAHA 4DNCA 1IY5A 2ENNA 1R79A 1M8BA 1AN1I 3OXGA 3R5DA 4HGUA 3GOXA 2ARPF 1BMOA 1CT2I 2V1CC 2JZMA 1Y8FA 1M8CA 2SGDI 1KMAA 1UHAA 1Y1CA 2CWHA 2NU0I 1TBNA 3UGLA 5J8FA 1MJBA 1K7VA 1PTRA 2GKTI 2FNFX 1KBFA 2NU4I 1MJ9A 1TIHA 5J8CA 2KMOA 1SGDI 1WGTA 4UXJA 3SEKC 1HEVA 2F3CI 2B0UC 2ELIA 2LB7A 2JXDA 1HJAI 1UVGA 1WKXA 2ODDA 3R5AA 7WGAA 1SGQI 2B8TA 1UVFA 3KY9A 1X74A 1XX6A 3CXLA 2ENZA 4E1PA 2J9RA 2SGQI 1W3SA 1OMUA
chains in the Genus database with same CATH topology
1PCEA 2V1CA 2SGFI 2GKRI 3QTLD 2BUSA 2SGPI 3UEJA 1TBOA 1PJUA 1PTQA 2DB6A 2DIPA 5FUXA 1YTPA 4SGBI 1HPTA 1OVOA 1Y1BA 3QWPA 3D00A 3UEYA 5FUYA 2QQCA 1YU6C 1MT1A 2N17A 3E2IA 3VDUA 3OL0A 2L7XA 2W0TA 1U5KA 2M5XA 2NU3I 5CCMA 2V53A 2CJSC 2VRWB 1N13A 2N52A 4A24A 2KMPA 2OD1A 3MEKA 5DAEA 1PPFI 3SGBI 1CHOI 1OYVI 1XBTA 4UXIA 5HI7A 1Z7KB 1DS3I 1FAQA 2KCXA 2LEOA 2QQEA 1IW4A 1VDDA 2QQ0A 1SGRI 1LR7A 4UXHA 2OVOA 1OMTA 3UGDA 1IY6A 2ERWA 1RFHA 1W4RA 2SGEI 2N71A 2WCYA 3E59A 2KMQA 2NU1I 1HDLA 3BJIA 5FUVA 2LUYA 5CCLA 1CSOI 1V1HA 2L8EA 3TJQA 2A20A 1DS2I 1TBRR 4B6DA 1KBEA 2YQPA 5FUWA 1H0ZA 3OVOA 1SGEI 3UGIA 3SGQI 1UUCA 1XA6A 5HQ8A 5JHWC 3VDPA 1TBQR 4GI3C 3FC3A 2JA1A 1NUBA 2N1AB 2YUUA 3PDNA 5EX3A 2NU2I 2KMRA 4OVOA 5EX0A 2K9HA 2ROWA 2E5RA 1TURA 2QPOA 1LR9A 2JW6A 1TGSI 2WVJA 3RU0A 4FKDA 3OXLA 2P6AC 3UFFA 2GKVA 4E1RA 1TUSA 2E73A 1TOTA 1CT4I 4L9MA 2JYYA 1CE3A 1FYBA 1SGYI 1CT0I 3VE5A 1LR8A 2ORVA 1R0RI 4JCVE 1CGII 2QQDA 2J87A 1X4SA 2XRCA 3B4VC 1SGPI 1BUSA 1CGJI 1V1IA 2GVIA 3HH2C 1SGNI 2UZ3A 3OXFA 2ORWA 1FARA 1IY5A 2ENNA 1R79A 1M8BA 1AN1I 3OXGA 3GOXA 4HGUA 2ARPF 1BMOA 1CT2I 2V1CC 2JZMA 1Y8FA 1M8CA 2SGDI 1KMAA 1Y1CA 2NU0I 1TBNA 3UGLA 1PTRA 2GKTI 2FNFX 1KBFA 2NU4I 1TIHA 2KMOA 1SGDI 4UXJA 3SEKC 2F3CI 2B0UC 2ELIA 2JXDA 1HJAI 1UVGA 2ODDA 1SGQI 2B8TA 1UVFA 3KY9A 1X74A 1XX6A 3CXLA 2ENZA 4E1PA 2J9RA 2SGQI 1W3SA 1OMUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PCE A;  2SGF I;  2GKR I;  3QTL D;  2BUS A;  2SGP I;  1PJU A;  1YTP A;  4SGB I;  1HPT A;  1OVO A;  1Y1B A;  2QQC A;  1YU6 C;  1MT1 A;  2N17 A;  2M5X A;  2NU3 I;  2V53 A;  1N13 A;  2N52 A;  2KMP A;  5DAE A;  1PPF I;  3SGB I;  1CHO I;  1OYV I;  1Z7K B;  2KCX A;  2LEO A;  1IW4 A;  1SGR I;  1LR7 A;  1IY6 A;  2OVO A;  1OMT A;  2ERW A;  2SGE I;  2N71 A;  2WCY A;  2KMQ A;  2NU1 I;  1HDL A;  1CSO I;  3TJQ A;  1DS2 I;  1TBR R;  1H0Z A;  3OVO A;  1SGE I;  3SGQ I;  1UUC A;  5JHW C;  1TBQ R;  4GI3 C;  1NUB A;  2NU2 I;  2KMR A;  4OVO A;  1TUR A;  1LR9 A;  1TGS I;  2P6A C;  2GKV A;  1TUS A;  1CT4 I;  1CE3 A;  2JYY A;  1FYB A;  1SGY I;  1CT0 I;  1LR8 A;  1R0R I;  1CGI I;  2QQD A;  2XRC A;  3B4V C;  1SGP I;  1BUS A;  1CGJ I;  3HH2 C;  1SGN I;  1IY5 A;  1M8B A;  1AN1 I;  4HGU A;  2ARP F;  1BMO A;  1CT2 I;  2JZM A;  1M8C A;  2SGD I;  1KMA A;  1Y1C A;  2NU0 I;  2GKT I;  2NU4 I;  1TIH A;  2KMO A;  1SGD I;  3SEK C;  2F3C I;  2B0U C;  2JXD A;  1HJA I;  1UVG A;  1SGQ I;  1UVF A;  2SGQ I;  1DS3 I;  1OMU A; 
#chains in the Genus database with same CATH topology
 1PCE A;  2V1C A;  2SGF I;  2GKR I;  3QTL D;  3TO6 A;  1MJA A;  4WP4 A;  1Q9B A;  1WGC A;  2BUS A;  2SGP I;  3UEJ A;  1TBO A;  1PJU A;  2Y0M A;  5E3Q A;  1PTQ A;  2DB6 A;  2DIP A;  5FUX A;  1YTP A;  1ULK A;  4SGB I;  1HPT A;  1OVO A;  1K7T A;  1Y1B A;  3QWP A;  2X52 A;  3D00 A;  3UEY A;  5FUY A;  2QQC A;  1YU6 C;  1MT1 A;  2N17 A;  3E2I A;  5E3P A;  3VDU A;  3TO7 A;  3OL0 A;  1S20 A;  2L7X A;  2W0T A;  1U5K A;  2M5X A;  2NU3 I;  5CCM A;  2V53 A;  2CJS C;  2VRW B;  2DKV A;  1N13 A;  2N52 A;  4A24 A;  2KMP A;  2OD1 A;  2UVO A;  3MEK A;  5DAE A;  1PPF I;  1Z2I A;  3R5C A;  1CHO I;  3SGB I;  1OYV I;  1XBT A;  4UXI A;  5HI7 A;  1Z7K B;  1DS3 I;  1FAQ A;  2KCX A;  2LEO A;  2QQE A;  1IW4 A;  1VDD A;  2QQ0 A;  1SGR I;  3FSY A;  1LR7 A;  4UXH A;  2OVO A;  1OMT A;  3UGD A;  1IY6 A;  2ERW A;  1RFH A;  1W4R A;  2SGE I;  2N71 A;  2WCY A;  3E59 A;  2KMQ A;  1P9G A;  4MPI A;  3TOB A;  4AML A;  1P9Z A;  2NU1 I;  1HDL A;  3BJI A;  1K7U A;  2LUY A;  5FUV A;  5CCL A;  1CSO I;  1V1H A;  2L8E A;  3FSX A;  3TJQ A;  2A20 A;  1DS2 I;  1TBR R;  3R5B A;  2WGC A;  4B6D A;  1KBE A;  2YQP A;  5FUW A;  1H0Z A;  3OVO A;  1SGE I;  3UGI A;  3UOE A;  3SGQ I;  1UUC A;  1XA6 A;  5HQ8 A;  5JHW C;  3VDP A;  2OU2 A;  1TBQ R;  1FY7 A;  2RC4 A;  2CWG A;  4GI3 C;  3FC3 A;  2CWF A;  2JA1 A;  1NUB A;  2N1A B;  2YUU A;  3PDN A;  5EX3 A;  2NU2 I;  2KMR A;  4OVO A;  5EX0 A;  2K9H A;  2ROW A;  2E5R A;  1TUR A;  2QPO A;  1LR9 A;  2JW6 A;  1TGS I;  2WVJ A;  3RU0 A;  4FKD A;  3OXL A;  2P6A C;  3UFF A;  2GKV A;  4E1R A;  2GIV A;  1TUS A;  2E73 A;  1TOT A;  9WGA A;  3TOA A;  1CT4 I;  4L9M A;  2JYY A;  2X3T A;  1CE3 A;  1SGY I;  1CT0 I;  1FYB A;  3VE5 A;  1LR8 A;  2ORV A;  1R0R I;  4JCV E;  3TO9 A;  1ULM A;  2OZU A;  1CGI I;  2QQD A;  5E3R A;  1ULN A;  2J87 A;  1X4S A;  2XRC A;  3B4V C;  1SGP I;  1BUS A;  1CGJ I;  1V1I A;  1WTJ A;  2GVI A;  1SGN I;  2RIJ A;  2UZ3 A;  3HH2 C;  2ORW A;  1NXU A;  1FAR A;  2PQ8 A;  3OXF A;  3QAH A;  4DNC A;  1IY5 A;  2ENN A;  1R79 A;  1M8B A;  1AN1 I;  3OXG A;  3R5D A;  4HGU A;  3GOX A;  2ARP F;  1BMO A;  1CT2 I;  2V1C C;  2JZM A;  1Y8F A;  1M8C A;  2SGD I;  1KMA A;  1UHA A;  1Y1C A;  2CWH A;  2NU0 I;  1TBN A;  3UGL A;  5J8F A;  1MJB A;  1K7V A;  1PTR A;  2GKT I;  2FNF X;  1KBF A;  2NU4 I;  1MJ9 A;  1TIH A;  5J8C A;  2KMO A;  1SGD I;  1WGT A;  4UXJ A;  3SEK C;  1HEV A;  2F3C I;  2B0U C;  2ELI A;  2LB7 A;  2JXD A;  1HJA I;  1UVG A;  1WKX A;  2ODD A;  3R5A A;  7WGA A;  1SGQ I;  2B8T A;  1UVF A;  3KY9 A;  1X74 A;  1XX6 A;  3CXL A;  2ENZ A;  4E1P A;  2J9R A;  2SGQ I;  1W3S A;  1OMU A; 
#chains in the Genus database with same CATH homology
 1PCE A;  2V1C A;  2SGF I;  2GKR I;  3QTL D;  2BUS A;  2SGP I;  3UEJ A;  1TBO A;  1PJU A;  1PTQ A;  2DB6 A;  2DIP A;  5FUX A;  1YTP A;  4SGB I;  1HPT A;  1OVO A;  1Y1B A;  3QWP A;  3D00 A;  3UEY A;  5FUY A;  2QQC A;  1YU6 C;  1MT1 A;  2N17 A;  3E2I A;  3VDU A;  3OL0 A;  2L7X A;  2W0T A;  1U5K A;  2M5X A;  2NU3 I;  5CCM A;  2V53 A;  2CJS C;  2VRW B;  1N13 A;  2N52 A;  4A24 A;  2KMP A;  2OD1 A;  3MEK A;  5DAE A;  1PPF I;  3SGB I;  1CHO I;  1OYV I;  1XBT A;  4UXI A;  5HI7 A;  1Z7K B;  1DS3 I;  1FAQ A;  2KCX A;  2LEO A;  2QQE A;  1IW4 A;  1VDD A;  2QQ0 A;  1SGR I;  1LR7 A;  4UXH A;  2OVO A;  1OMT A;  3UGD A;  1IY6 A;  2ERW A;  1RFH A;  1W4R A;  2SGE I;  2N71 A;  2WCY A;  3E59 A;  2KMQ A;  2NU1 I;  1HDL A;  3BJI A;  5FUV A;  2LUY A;  5CCL A;  1CSO I;  1V1H A;  2L8E A;  3TJQ A;  2A20 A;  1DS2 I;  1TBR R;  4B6D A;  1KBE A;  2YQP A;  5FUW A;  1H0Z A;  3OVO A;  1SGE I;  3UGI A;  3SGQ I;  1UUC A;  1XA6 A;  5HQ8 A;  5JHW C;  3VDP A;  1TBQ R;  4GI3 C;  3FC3 A;  2JA1 A;  1NUB A;  2N1A B;  2YUU A;  3PDN A;  5EX3 A;  2NU2 I;  2KMR A;  4OVO A;  5EX0 A;  2K9H A;  2ROW A;  2E5R A;  1TUR A;  2QPO A;  1LR9 A;  2JW6 A;  1TGS I;  2WVJ A;  3RU0 A;  4FKD A;  3OXL A;  2P6A C;  3UFF A;  2GKV A;  4E1R A;  1TUS A;  2E73 A;  1TOT A;  1CT4 I;  4L9M A;  2JYY A;  1CE3 A;  1FYB A;  1SGY I;  1CT0 I;  3VE5 A;  1LR8 A;  2ORV A;  1R0R I;  4JCV E;  1CGI I;  2QQD A;  2J87 A;  1X4S A;  2XRC A;  3B4V C;  1SGP I;  1BUS A;  1CGJ I;  1V1I A;  2GVI A;  3HH2 C;  1SGN I;  2UZ3 A;  3OXF A;  2ORW A;  1FAR A;  1IY5 A;  2ENN A;  1R79 A;  1M8B A;  1AN1 I;  3OXG A;  3GOX A;  4HGU A;  2ARP F;  1BMO A;  1CT2 I;  2V1C C;  2JZM A;  1Y8F A;  1M8C A;  2SGD I;  1KMA A;  1Y1C A;  2NU0 I;  1TBN A;  3UGL A;  1PTR A;  2GKT I;  2FNF X;  1KBF A;  2NU4 I;  1TIH A;  2KMO A;  1SGD I;  4UXJ A;  3SEK C;  2F3C I;  2B0U C;  2ELI A;  2JXD A;  1HJA I;  1UVG A;  2ODD A;  1SGQ I;  2B8T A;  1UVF A;  3KY9 A;  1X74 A;  1XX6 A;  3CXL A;  2ENZ A;  4E1P A;  2J9R A;  2SGQ I;  1W3S A;  1OMU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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