4GI3C

Crystal structure of greglin in complex with subtilisin
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
57
structure length
57
Chain Sequence
CPSICPLIYAPVCVEDSNQDFYLFVNECEVRKCGCEAGFVYTFVPREMCKATTSLCP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of greglin, a novel non-classical Kazal inhibitor, in complex with subtilisin
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords KerA
total genus 8
structure length 57
sequence length 57
ec nomenclature
pdb deposition date 2012-08-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 4gi3C00
1CT4I 1R0RI 2XRCA 1SGQI 2NU1I 1N13A 5JHWC 1SGRI 1AN1I 2JZMA 2F3CI 1OVOA 1TUSA 2QQCA 1TIHA 1TGSI 1FYBA 1OMUA 2SGQI 1IY5A 2KMQA 2JYYA 1M8CA 2GKRI 3TJQA 1SGEI 3QTLD 1LR8A 1Y1BA 1H0ZA 1YTPA 1CT0I 1YU6C 2KMRA 1IY6A 2KMOA 1HDLA 2NU4I 1LR7A 1LR9A 2NU2I 2P6AC 1SGYI 1UUCA 3SEKC 1OMTA 1IW4A 4HGUA 1TBQR 1CT2I 3SGBI 2B0UC 1CSOI 2SGPI 1CHOI 1PCEA 1SGNI 3SGQI 1PPFI 2GKVA 2JXDA 3OVOA 1NUBA 1UVGA 2LEOA 1UVFA 1HPTA 4GI3C 5DAEA 1PJUA 1SGDI 2N71A 2BUSA 2SGDI 2SGFI 2NU3I 1Z7KB 2M5XA 1TURA 2OVOA 1OYVI 2QQDA 1CGII 1DS3I 1SGPI 2ARPF 2WCYA 1BUSA 1CE3A 2KCXA 3HH2C 2NU0I 1M8BA 2KMPA 3B4VC 1HJAI 1BMOA 1CGJI 2ERWA 4SGBI 1Y1CA 1KMAA 2V53A 2GKTI 2SGEI 1MT1A 4OVOA 1DS2I 1TBRR 2N17A 2N52A
chains in the Genus database with same CATH superfamily
1CT4I 1K7VA 5EX0A 3UGIA 3R5BA 1R0RI 1R79A 4E1RA 2XRCA 1SGQI 2GVIA 2NU1I 1N13A 5JHWC 4JCVE 2YUUA 1WGCA 2FNFX 1SGRI 2VRWB 3TOBA 4AMLA 2Y0MA 1IY6A 3UFFA 2ORWA 3UEJA 1AN1I 2JZMA 2F3CI 2J9RA 2JA1A 3R5AA 3UGLA 3UGDA 1FY7A 1OVOA 1TUSA 3E59A 5FUVA 4MPIA 2QQCA 1VDDA 3VE5A 3PDNA 1TIHA 1U5KA 2RIJA 2V1CC 4B6DA 4UXIA 1TBNA 1TGSI 2DKVA 4E1PA 1OMUA 2PQ8A 1FYBA 2CWFA 2SGQI 3MEKA 2UVOA 2CJSC 2J87A 1ULKA 5E3QA 1IY5A 2KMQA 2N1AB 2JYYA 3OXLA 4UXHA 1XBTA 5CCMA 1M8CA 2GKRI 3TJQA 1SGEI 2QQ0A 2K9HA 2E73A 5EX3A 4UXJA 2CWHA 5HI7A 3QTLD 3QAHA 5FUWA 2A20A 2DIPA 2L7XA 1LR8A 1Y1BA 1ULMA 1H0ZA 1XX6A 1YTPA 7WGAA 3FC3A 1CT0I 1XA6A 1K7UA 1YU6C 2KMRA 2KMOA 2ORVA 3R5DA 2OZUA 4L9MA 3TO7A 1HDLA 1P9ZA 2NU4I 2ENZA 1LR7A 1LR9A 2NU2I 2P6AC 2QQEA 1SGYI 1UUCA 2WVJA 5CCLA 3TO9A 3SEKC 1OMTA 1WKXA 2OD1A 1FARA 1Y8FA 2UZ3A 1IW4A 4HGUA 1TBQR 1NXUA 3UOEA 1CT2I 3SGBI 1TBOA 4DNCA 2B0UC 2DB6A 1CSOI 2CWGA 5FUXA 1MJAA 2SGPI 1CHOI 1PCEA 1SGNI 3SGQI 1PPFI 1KBEA 2GKVA 2JXDA 3OXGA 5FUYA 1WTJA 1S20A 1ULNA 1NUBA 3OVOA 3OL0A 2E5RA 1UVGA 2LEOA 1UVFA 1HPTA 1MJ9A 4GI3C 2ODDA 1Z2IA 4WP4A 5HQ8A 2LUYA 5J8CA 5DAEA 3D00A 1X74A 1PJUA 1SGDI 2N71A 2BUSA 3R5CA 1FAQA 2L8EA 2OU2A 2SGDI 2SGFI 2NU3I 1Z7KB 2M5XA 1TURA 2ENNA 3FSXA 1KBFA 3UEYA 2QPOA 1V1IA 1UHAA 9WGAA 3QWPA 2W0TA 2OVOA 4FKDA 3GOXA 1OYVI 1W3SA 2ELIA 2QQDA 1CGII 1DS3I 2B8TA 3FSYA 2ROWA 1SGPI 2ARPF 3VDUA 2WCYA 1Q9BA 1BUSA 1CE3A 2WGCA 4A24A 3E2IA 2KCXA 3HH2C 1W4RA 1X4SA 2NU0I 1M8BA 1WGTA 1P9GA 2KMPA 2RC4A 1MJBA 1HJAI 1BMOA 1CGJI 3B4VC 2ERWA 3OXFA 5E3RA 2X52A 3RU0A 3TOAA 4SGBI 1Y1CA 1KMAA 2V53A 2GKTI 2V1CA 1TOTA 2SGEI 3KY9A 5J8FA 1MT1A 3VDPA 1HEVA 4OVOA 1DS2I 1PTQA 1TBRR 2N17A 1K7TA 2GIVA 2X3TA 3TO6A 1RFHA 5E3PA 3BJIA 1PTRA 1V1HA 2JW6A 2YQPA 3CXLA 2N52A 2LB7A
chains in the Genus database with same CATH topology
1CT4I 5EX0A 3UGIA 1R0RI 1R79A 4E1RA 2XRCA 1SGQI 2GVIA 2NU1I 1N13A 5JHWC 4JCVE 2YUUA 2FNFX 1SGRI 2VRWB 3UFFA 2ORWA 3UEJA 1AN1I 2JZMA 2F3CI 2J9RA 2JA1A 3UGLA 3UGDA 1OVOA 1TUSA 3E59A 5FUVA 2QQCA 1VDDA 3VE5A 3PDNA 1TIHA 1U5KA 2V1CC 4B6DA 4UXIA 1TBNA 1TGSI 4E1PA 1OMUA 1FYBA 2SGQI 3MEKA 2CJSC 2J87A 1IY5A 2KMQA 2N1AB 2JYYA 3OXLA 4UXHA 1XBTA 5CCMA 1M8CA 2GKRI 3TJQA 1SGEI 2QQ0A 2K9HA 2E73A 5EX3A 4UXJA 5HI7A 3QTLD 5FUWA 2A20A 2DIPA 2L7XA 1LR8A 1Y1BA 1H0ZA 1XX6A 1YTPA 3FC3A 1CT0I 1XA6A 1YU6C 2KMRA 2KMOA 2ORVA 4L9MA 1IY6A 1HDLA 2NU4I 2ENZA 1LR7A 1LR9A 2NU2I 2P6AC 2QQEA 1SGYI 1UUCA 2WVJA 5CCLA 3SEKC 1OMTA 2OD1A 1FARA 1Y8FA 2UZ3A 1IW4A 4HGUA 1TBQR 1CT2I 3SGBI 1TBOA 2B0UC 2DB6A 1CSOI 5FUXA 2SGPI 1CHOI 1PCEA 1SGNI 3SGQI 1PPFI 1KBEA 2GKVA 2JXDA 3OXGA 5FUYA 3OVOA 1NUBA 3OL0A 2E5RA 1UVGA 2LEOA 1UVFA 1HPTA 4GI3C 5HQ8A 2ODDA 3GOXA 2LUYA 5DAEA 3D00A 1X74A 1PJUA 1SGDI 2N71A 2BUSA 1FAQA 2L8EA 2SGDI 2SGFI 2NU3I 1Z7KB 2M5XA 1TURA 2ENNA 1KBFA 3UEYA 2QPOA 1V1IA 3QWPA 2W0TA 2OVOA 4FKDA 1OYVI 1W3SA 2ELIA 2QQDA 1CGII 1DS3I 2B8TA 2ROWA 1SGPI 2ARPF 3VDUA 2WCYA 1BUSA 1CE3A 4A24A 3E2IA 2KCXA 3HH2C 1W4RA 1X4SA 2NU0I 1M8BA 3OXFA 2KMPA 3B4VC 1HJAI 1BMOA 1CGJI 3RU0A 2ERWA 4SGBI 1Y1CA 1KMAA 2V53A 2GKTI 2V1CA 1TOTA 2SGEI 3KY9A 1MT1A 3VDPA 4OVOA 1DS2I 1PTQA 1TBRR 2N17A 1RFHA 3BJIA 1PTRA 1V1HA 2JW6A 2YQPA 3CXLA 2N52A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1CT4 I;  1R0R I;  2XRC A;  1SGQ I;  2NU1 I;  1N13 A;  5JHW C;  1SGR I;  1AN1 I;  2JZM A;  2F3C I;  1OVO A;  1TUS A;  2QQC A;  1TIH A;  1TGS I;  1FYB A;  1OMU A;  2SGQ I;  1IY5 A;  2KMQ A;  2JYY A;  1M8C A;  2GKR I;  3TJQ A;  1SGE I;  3QTL D;  1LR8 A;  1Y1B A;  1H0Z A;  1YTP A;  1CT0 I;  1YU6 C;  2KMR A;  1IY6 A;  2KMO A;  1HDL A;  2NU4 I;  1LR7 A;  1LR9 A;  2NU2 I;  2P6A C;  1SGY I;  1UUC A;  3SEK C;  1OMT A;  1IW4 A;  4HGU A;  1TBQ R;  1CT2 I;  3SGB I;  2B0U C;  1CSO I;  2SGP I;  1CHO I;  1PCE A;  1SGN I;  3SGQ I;  1PPF I;  2GKV A;  2JXD A;  3OVO A;  1NUB A;  1UVG A;  2LEO A;  1UVF A;  1HPT A;  4GI3 C;  5DAE A;  1PJU A;  1SGD I;  2N71 A;  2BUS A;  2SGD I;  2SGF I;  2NU3 I;  1Z7K B;  2M5X A;  1TUR A;  2OVO A;  1OYV I;  2QQD A;  1CGI I;  1DS3 I;  1SGP I;  2ARP F;  2WCY A;  1BUS A;  1CE3 A;  2KCX A;  3HH2 C;  2NU0 I;  1M8B A;  2KMP A;  3B4V C;  1HJA I;  1BMO A;  1CGJ I;  2ERW A;  4SGB I;  1Y1C A;  1KMA A;  2V53 A;  2GKT I;  2SGE I;  1MT1 A;  4OVO A;  1DS2 I;  1TBR R;  2N17 A;  2N52 A; 
#chains in the Genus database with same CATH topology
 1CT4 I;  1K7V A;  5EX0 A;  3UGI A;  3R5B A;  1R0R I;  1R79 A;  4E1R A;  2XRC A;  1SGQ I;  2GVI A;  2NU1 I;  1N13 A;  5JHW C;  4JCV E;  2YUU A;  1WGC A;  2FNF X;  1SGR I;  2VRW B;  3TOB A;  4AML A;  2Y0M A;  1IY6 A;  3UFF A;  2ORW A;  3UEJ A;  1AN1 I;  2JZM A;  2F3C I;  2J9R A;  2JA1 A;  3R5A A;  3UGL A;  3UGD A;  1FY7 A;  1OVO A;  1TUS A;  3E59 A;  5FUV A;  4MPI A;  2QQC A;  1VDD A;  3VE5 A;  3PDN A;  1TIH A;  1U5K A;  2RIJ A;  2V1C C;  4B6D A;  4UXI A;  1TBN A;  1TGS I;  2DKV A;  4E1P A;  1OMU A;  2PQ8 A;  1FYB A;  2CWF A;  2SGQ I;  3MEK A;  2UVO A;  2CJS C;  2J87 A;  1ULK A;  5E3Q A;  1IY5 A;  2KMQ A;  2N1A B;  2JYY A;  3OXL A;  4UXH A;  1XBT A;  5CCM A;  1M8C A;  2GKR I;  3TJQ A;  1SGE I;  2QQ0 A;  2K9H A;  2E73 A;  5EX3 A;  4UXJ A;  2CWH A;  5HI7 A;  3QTL D;  3QAH A;  5FUW A;  2A20 A;  2DIP A;  2L7X A;  1LR8 A;  1Y1B A;  1ULM A;  1H0Z A;  1XX6 A;  1YTP A;  7WGA A;  3FC3 A;  1CT0 I;  1XA6 A;  1K7U A;  1YU6 C;  2KMR A;  2KMO A;  2ORV A;  3R5D A;  2OZU A;  4L9M A;  3TO7 A;  1HDL A;  1P9Z A;  2NU4 I;  2ENZ A;  1LR7 A;  1LR9 A;  2NU2 I;  2P6A C;  2QQE A;  1SGY I;  1UUC A;  2WVJ A;  5CCL A;  3TO9 A;  3SEK C;  1OMT A;  1WKX A;  2OD1 A;  1FAR A;  1Y8F A;  2UZ3 A;  1IW4 A;  4HGU A;  1TBQ R;  1NXU A;  3UOE A;  1CT2 I;  3SGB I;  1TBO A;  4DNC A;  2B0U C;  2DB6 A;  1CSO I;  2CWG A;  5FUX A;  1MJA A;  2SGP I;  1CHO I;  1PCE A;  1SGN I;  3SGQ I;  1PPF I;  1KBE A;  2GKV A;  2JXD A;  3OXG A;  5FUY A;  1WTJ A;  1S20 A;  1ULN A;  1NUB A;  3OVO A;  3OL0 A;  2E5R A;  1UVG A;  2LEO A;  1UVF A;  1HPT A;  1MJ9 A;  4GI3 C;  2ODD A;  1Z2I A;  4WP4 A;  5HQ8 A;  2LUY A;  5J8C A;  5DAE A;  3D00 A;  1X74 A;  1PJU A;  1SGD I;  2N71 A;  2BUS A;  3R5C A;  1FAQ A;  2L8E A;  2OU2 A;  2SGD I;  2SGF I;  2NU3 I;  1Z7K B;  2M5X A;  1TUR A;  2ENN A;  3FSX A;  1KBF A;  3UEY A;  2QPO A;  1V1I A;  1UHA A;  9WGA A;  3QWP A;  2W0T A;  2OVO A;  4FKD A;  3GOX A;  1OYV I;  1W3S A;  2ELI A;  2QQD A;  1CGI I;  1DS3 I;  2B8T A;  3FSY A;  2ROW A;  1SGP I;  2ARP F;  3VDU A;  2WCY A;  1Q9B A;  1BUS A;  1CE3 A;  2WGC A;  4A24 A;  3E2I A;  2KCX A;  3HH2 C;  1W4R A;  1X4S A;  2NU0 I;  1M8B A;  1WGT A;  1P9G A;  2KMP A;  2RC4 A;  1MJB A;  1HJA I;  1BMO A;  1CGJ I;  3B4V C;  2ERW A;  3OXF A;  5E3R A;  2X52 A;  3RU0 A;  3TOA A;  4SGB I;  1Y1C A;  1KMA A;  2V53 A;  2GKT I;  2V1C A;  1TOT A;  2SGE I;  3KY9 A;  5J8F A;  1MT1 A;  3VDP A;  1HEV A;  4OVO A;  1DS2 I;  1PTQ A;  1TBR R;  2N17 A;  1K7T A;  2GIV A;  2X3T A;  3TO6 A;  1RFH A;  5E3P A;  3BJI A;  1PTR A;  1V1H A;  2JW6 A;  2YQP A;  3CXL A;  2N52 A;  2LB7 A; 
#chains in the Genus database with same CATH homology
 1CT4 I;  5EX0 A;  3UGI A;  1R0R I;  1R79 A;  4E1R A;  2XRC A;  1SGQ I;  2GVI A;  2NU1 I;  1N13 A;  5JHW C;  4JCV E;  2YUU A;  2FNF X;  1SGR I;  2VRW B;  3UFF A;  2ORW A;  3UEJ A;  1AN1 I;  2JZM A;  2F3C I;  2J9R A;  2JA1 A;  3UGL A;  3UGD A;  1OVO A;  1TUS A;  3E59 A;  5FUV A;  2QQC A;  1VDD A;  3VE5 A;  3PDN A;  1TIH A;  1U5K A;  2V1C C;  4B6D A;  4UXI A;  1TBN A;  1TGS I;  4E1P A;  1OMU A;  1FYB A;  2SGQ I;  3MEK A;  2CJS C;  2J87 A;  1IY5 A;  2KMQ A;  2N1A B;  2JYY A;  3OXL A;  4UXH A;  1XBT A;  5CCM A;  1M8C A;  2GKR I;  3TJQ A;  1SGE I;  2QQ0 A;  2K9H A;  2E73 A;  5EX3 A;  4UXJ A;  5HI7 A;  3QTL D;  5FUW A;  2A20 A;  2DIP A;  2L7X A;  1LR8 A;  1Y1B A;  1H0Z A;  1XX6 A;  1YTP A;  3FC3 A;  1CT0 I;  1XA6 A;  1YU6 C;  2KMR A;  2KMO A;  2ORV A;  4L9M A;  1IY6 A;  1HDL A;  2NU4 I;  2ENZ A;  1LR7 A;  1LR9 A;  2NU2 I;  2P6A C;  2QQE A;  1SGY I;  1UUC A;  2WVJ A;  5CCL A;  3SEK C;  1OMT A;  2OD1 A;  1FAR A;  1Y8F A;  2UZ3 A;  1IW4 A;  4HGU A;  1TBQ R;  1CT2 I;  3SGB I;  1TBO A;  2B0U C;  2DB6 A;  1CSO I;  5FUX A;  2SGP I;  1CHO I;  1PCE A;  1SGN I;  3SGQ I;  1PPF I;  1KBE A;  2GKV A;  2JXD A;  3OXG A;  5FUY A;  3OVO A;  1NUB A;  3OL0 A;  2E5R A;  1UVG A;  2LEO A;  1UVF A;  1HPT A;  4GI3 C;  5HQ8 A;  2ODD A;  3GOX A;  2LUY A;  5DAE A;  3D00 A;  1X74 A;  1PJU A;  1SGD I;  2N71 A;  2BUS A;  1FAQ A;  2L8E A;  2SGD I;  2SGF I;  2NU3 I;  1Z7K B;  2M5X A;  1TUR A;  2ENN A;  1KBF A;  3UEY A;  2QPO A;  1V1I A;  3QWP A;  2W0T A;  2OVO A;  4FKD A;  1OYV I;  1W3S A;  2ELI A;  2QQD A;  1CGI I;  1DS3 I;  2B8T A;  2ROW A;  1SGP I;  2ARP F;  3VDU A;  2WCY A;  1BUS A;  1CE3 A;  4A24 A;  3E2I A;  2KCX A;  3HH2 C;  1W4R A;  1X4S A;  2NU0 I;  1M8B A;  3OXF A;  2KMP A;  3B4V C;  1HJA I;  1BMO A;  1CGJ I;  3RU0 A;  2ERW A;  4SGB I;  1Y1C A;  1KMA A;  2V53 A;  2GKT I;  2V1C A;  1TOT A;  2SGE I;  3KY9 A;  1MT1 A;  3VDP A;  4OVO A;  1DS2 I;  1PTQ A;  1TBR R;  2N17 A;  1RFH A;  3BJI A;  1PTR A;  1V1H A;  2JW6 A;  2YQP A;  3CXL A;  2N52 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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