The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
65
|
sequence length |
288
|
structure length |
282
|
Chain Sequence |
GNCWLRQAKNGRCQVLYKTELSKEECCSTGRLSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSCN
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Structural basis for potency differences between GDF8 and GDF11.
pubmed doi rcsb |
| molecule keywords |
Growth/differentiation factor 11
|
| molecule tags |
Cytokine/signaling protein
|
| source organism |
Homo sapiens
|
| total genus |
65
|
| structure length |
282
|
| sequence length |
288
|
| chains with identical sequence |
D
|
| ec nomenclature | |
| pdb deposition date | 2016-04-21 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| C | PF07648 | Kazal_2 | Kazal-type serine protease inhibitor domain |
| C | PF09289 | FOLN | Follistatin/Osteonectin-like EGF domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | 2-Layer Sandwich | Wheat Germ Agglutinin (Isolectin 2); domain 1 | Wheat Germ Agglutinin (Isolectin 2); domain 1 | ||
| Alpha Beta | 2-Layer Sandwich | Wheat Germ Agglutinin (Isolectin 2); domain 1 | Wheat Germ Agglutinin (Isolectin 2); domain 1 | ||
| Alpha Beta | 2-Layer Sandwich | Wheat Germ Agglutinin (Isolectin 2); domain 1 | Wheat Germ Agglutinin (Isolectin 2); domain 1 | ||
| Alpha Beta | Alpha-Beta Complex | Extracellular Matrix Fibrillin | TGF-beta binding (TB) domain |
#chains in the Genus database with same CATH superfamily 3SEK C; 1UUC A; 2ARP F; 2QQD A; 2SGD I; 1FYB A; 2JXD A; 1APJ A; 1OMT A; 2XRC A; 3SGQ I; 1OYV I; 1IW4 A; 1UZJ A; 1Z7K B; 2JZM A; 2NU3 I; 1SGR I; 3TJQ A; 1TIH A; 1KSQ A; 1MT1 A; 1M8B A; 2JYY A; 1BMO A; 1M8C A; 2WCY A; 2GKV A; 1CGI I; 2NU4 I; 1TUR A; 1SGY I; 2GKT I; 2M5X A; 2KMQ A; 2SGE I; 1CHO I; 1CE3 A; 2NU2 I; 1SGP I; 1UZK A; 1AN1 I; 2OVO A; 1DS2 I; 2BUS A; 2KMO A; 1H0Z A; 2ERW A; 1HJA I; 2SGQ I; 1SGN I; 1Y1C A; 4HGU A; 1CSO I; 1CGJ I; 3QTL D; 2KMR A; 2NU1 I; 1SGQ I; 1PPF I; 2N52 A; 1DS3 I; 1CT0 I; 1N13 A; 1R0R I; 1IY6 A; 2NU0 I; 5JHW C; 1SGD I; 1UZQ A; 1TGS I; 1OMU A; 2KCX A; 2B0U C; 1HPT A; 1TUS A; 1LR9 A; 2N17 A; 2LEO A; 2GKR I; 2SGF I; 1Y1B A; 1PJU A; 1YU6 C; 3SGB I; 4OVO A; 3B4V C; 1LR8 A; 1PCE A; 2W86 A; 2QQC A; 5DAE A; 2F3C I; 2P6A C; 1NUB A; 2KMP A; 2SGP I; 1UZP A; 1TBQ R; 1LR7 A; 1CT4 I; 3OVO A; 1OVO A; 1UVF A; 2V53 A; 1HDL A; 1BUS A; 1TBR R; 4GI3 C; 1SGE I; 1KMA A; 1CT2 I; 4SGB I; 1IY5 A; 1YTP A; 2N71 A; 3HH2 C; 1UVG A; #chains in the Genus database with same CATH topology 2GIV A; 3SEK C; 1X74 A; 1UUC A; 2FNF X; 2ARP F; 3TO6 A; 2QQD A; 2SGD I; 3TO9 A; 5CCL A; 1FYB A; 9WGA A; 2OU2 A; 2B8T A; 3VDU A; 3E2I A; 2JXD A; 1ULM A; 1APJ A; 2YQP A; 1OMT A; 5FUX A; 2XRC A; 3SGQ I; 2CWF A; 2L7X A; 1OYV I; 5FUV A; 4UXI A; 4B6D A; 1IW4 A; 1UZJ A; 2A20 A; 2DKV A; 2ENZ A; 2W0T A; 5HI7 A; 3VDP A; 1Z7K B; 2DIP A; 2JZM A; 1U5K A; 2NU3 I; 2ELI A; 3VE5 A; 1SGR I; 4A24 A; 3TJQ A; 2CWG A; 1TIH A; 3UGL A; 3UFF A; 4DNC A; 2OD1 A; 2ORV A; 2UVO A; 1VDD A; 3GOX A; 1KSQ A; 1MT1 A; 3OL0 A; 2VRW B; 1FAQ A; 2RIJ A; 1KBE A; 1M8B A; 2JA1 A; 1X4S A; 2JYY A; 1BMO A; 2YUU A; 1M8C A; 4WP4 A; 2WCY A; 2GKV A; 1CGI I; 1MJ9 A; 1WKX A; 4AML A; 3D00 A; 1KBF A; 2NU4 I; 5E3Q A; 1TUR A; 2N1A B; 1SGY I; 2GKT I; 3RU0 A; 2M5X A; 3KY9 A; 3TOB A; 2KMQ A; 1Y8F A; 2SGE I; 1CHO I; 3QWP A; 5E3P A; 5J8C A; 2X3T A; 3UEJ A; 2ORW A; 1CE3 A; 1S20 A; 2NU2 I; 2ENN A; 2E73 A; 1SGP I; 1UZK A; 4MPI A; 1AN1 I; 2QQ0 A; 2OVO A; 1DS2 I; 2BUS A; 2KMO A; 1H0Z A; 2ERW A; 1HJA I; 2WVJ A; 2ROW A; 2V1C C; 2SGQ I; 3TO7 A; 1XX6 A; 2LUY A; 3R5A A; 1SGN I; 1Y1C A; 4HGU A; 1CSO I; 4FKD A; 2L8E A; 1CGJ I; 3QTL D; 1K7T A; 2KMR A; 2NU1 I; 2E5R A; 2X52 A; 3PDN A; 1SGQ I; 3TOA A; 1PPF I; 2N52 A; 1DS3 I; 1TOT A; 2CJS C; 2QQE A; 1CT0 I; 1NXU A; 2K9H A; 5HQ8 A; 3R5B A; 1N13 A; 3R5C A; 1R0R I; 4UXJ A; 5E3R A; 2LB7 A; 2NU0 I; 3UOE A; 1ULK A; 1SGD I; 3OXL A; 5JHW C; 1P9Z A; 2Y0M A; 1UZQ A; 2OZU A; 1TGS I; 1OMU A; 2KCX A; 2B0U C; 4E1P A; 1FAR A; 2QPO A; 1TBN A; 2RC4 A; 1HPT A; 1TUS A; 2ODD A; 1LR9 A; 2N17 A; 3E59 A; 5CCM A; 3FSX A; 2LEO A; 2DB6 A; 1MJB A; 2GKR I; 2JW6 A; 5J8F A; 1WGC A; 2SGF I; 1W4R A; 2GVI A; 7WGA A; 1Y1B A; 1PJU A; 4E1R A; 1PTQ A; 5EX0 A; 1YU6 C; 3SGB I; 4OVO A; 3MEK A; 3FSY A; 3B4V C; 2CWH A; 2PQ8 A; 1LR8 A; 3BJI A; 1PCE A; 1K7V A; 3OXF A; 3OXG A; 5EX3 A; 1W3S A; 3CXL A; 3QAH A; 3UEY A; 2W86 A; 2QQC A; 5DAE A; 2F3C I; 2P6A C; 1NUB A; 2J9R A; 2UZ3 A; 2WGC A; 4UXH A; 2KMP A; 2SGP I; 3FC3 A; 1XA6 A; 3UGD A; 1Q9B A; 2J87 A; 1UZP A; 1R79 A; 1ULN A; 1K7U A; 3R5D A; 1TBQ R; 3UGI A; 1IY6 A; 1LR7 A; 1CT4 I; 3OVO A; 1PTR A; 1UHA A; 1MJA A; 1OVO A; 1P9G A; 1UVF A; 1WGT A; 1V1I A; 1TBO A; 1RFH A; 1WTJ A; 4L9M A; 2V53 A; 1Z2I A; 5FUY A; 1HEV A; 1V1H A; 1HDL A; 4JCV E; 1BUS A; 1XBT A; 5FUW A; 1TBR R; 4GI3 C; 1SGE I; 1KMA A; 1CT2 I; 1FY7 A; 4SGB I; 1YTP A; 2V1C A; 2N71 A; 3HH2 C; 1IY5 A; 1UVG A; #chains in the Genus database with same CATH homology 3SEK C; 1X74 A; 1UUC A; 2FNF X; 2ARP F; 5CCL A; 2QQD A; 2SGD I; 1FYB A; 2B8T A; 3VDU A; 3E2I A; 2JXD A; 1APJ A; 2YQP A; 1OMT A; 5FUX A; 2XRC A; 3SGQ I; 2L7X A; 5FUV A; 1OYV I; 4UXI A; 4B6D A; 1IW4 A; 1UZJ A; 2A20 A; 5HI7 A; 2ENZ A; 2W0T A; 3VDP A; 1Z7K B; 2DIP A; 2JZM A; 1U5K A; 2NU3 I; 2ELI A; 3VE5 A; 1SGR I; 4A24 A; 3TJQ A; 3UGL A; 1TIH A; 3UFF A; 2OD1 A; 2ORV A; 3GOX A; 1VDD A; 1KSQ A; 1MT1 A; 3OL0 A; 2VRW B; 1FAQ A; 1KBE A; 1M8B A; 2JA1 A; 1X4S A; 2JYY A; 1BMO A; 2YUU A; 1M8C A; 2WCY A; 2GKV A; 1CGI I; 3D00 A; 1KBF A; 2NU4 I; 1TUR A; 2N1A B; 1SGY I; 2GKT I; 3RU0 A; 2M5X A; 3KY9 A; 2KMQ A; 1Y8F A; 2SGE I; 1CHO I; 3QWP A; 3UEJ A; 2ORW A; 1CE3 A; 2NU2 I; 2ENN A; 2E73 A; 1SGP I; 1UZK A; 1AN1 I; 2QQ0 A; 2OVO A; 1DS2 I; 2BUS A; 2KMO A; 1H0Z A; 2ERW A; 1HJA I; 2WVJ A; 2ROW A; 2V1C C; 2SGQ I; 1XX6 A; 2LUY A; 1SGN I; 1Y1C A; 4HGU A; 1CSO I; 4FKD A; 2L8E A; 1CGJ I; 3QTL D; 2KMR A; 2NU1 I; 2E5R A; 3PDN A; 1SGQ I; 1PPF I; 2N52 A; 1DS3 I; 1TOT A; 2CJS C; 2QQE A; 1CT0 I; 2K9H A; 5HQ8 A; 1N13 A; 1R0R I; 4UXJ A; 1IY6 A; 2NU0 I; 5JHW C; 1SGD I; 3OXL A; 1UZQ A; 1TGS I; 1OMU A; 2KCX A; 2B0U C; 4E1P A; 1FAR A; 2QPO A; 1TBN A; 1HPT A; 1TUS A; 2ODD A; 1LR9 A; 2N17 A; 3E59 A; 5CCM A; 2LEO A; 2DB6 A; 2GKR I; 2JW6 A; 2SGF I; 1W4R A; 2GVI A; 1Y1B A; 1PJU A; 4E1R A; 1PTQ A; 5EX0 A; 1YU6 C; 3SGB I; 4OVO A; 3MEK A; 3B4V C; 3BJI A; 1LR8 A; 3OXF A; 1PCE A; 3OXG A; 3UEY A; 5EX3 A; 1W3S A; 3CXL A; 2W86 A; 2QQC A; 5DAE A; 2F3C I; 2P6A C; 1NUB A; 2J9R A; 2UZ3 A; 4UXH A; 3FC3 A; 2KMP A; 2SGP I; 1XA6 A; 3UGD A; 1UZP A; 2J87 A; 1R79 A; 3UGI A; 1TBQ R; 1LR7 A; 1CT4 I; 3OVO A; 1PTR A; 1OVO A; 1UVF A; 1V1I A; 1TBO A; 1RFH A; 4L9M A; 5FUY A; 2V53 A; 1V1H A; 1HDL A; 4JCV E; 1BUS A; 1XBT A; 5FUW A; 1TBR R; 4GI3 C; 1SGE I; 1KMA A; 1CT2 I; 4SGB I; 1IY5 A; 1YTP A; 2V1C A; 2N71 A; 3HH2 C; 1UVG A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
