The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
40
|
sequence length |
162
|
structure length |
162
|
Chain Sequence |
LLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPL
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
The Amyloid Precursor Protein Shows a pH-Dependent Conformational Switch in Its E1 Domain.
pubmed doi rcsb |
| molecule keywords |
Amyloid beta A4 protein
|
| molecule tags |
Heparin binding protein
|
| source organism |
Homo sapiens
|
| total genus |
40
|
| structure length |
162
|
| sequence length |
162
|
| chains with identical sequence |
B
|
| ec nomenclature | |
| pdb deposition date | 2014-03-21 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF02177 | APP_N | Amyloid A4 N-terminal heparin-binding |
| A | PF12924 | APP_Cu_bd | Copper-binding of amyloid precursor, CuBD |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | 2-Layer Sandwich | Dna Ligase; domain 1 | Amyloidogenic glycoprotein, copper-binding domain | ||
| Alpha Beta | Alpha-Beta Complex | Sugar Binding Protein, Amyloid A4 Protein; Chain A | Amyloidogenic glycoprotein, heparin-binding domain |
#chains in the Genus database with same CATH superfamily 2FKL A; 2FJZ A; 2FK3 A; 4PQD A; 2FK1 A; 2FMA A; 2FK2 A; 1MWP A; 4JFN A; 2M05 A; 4PWQ A; 3KTM A; 1OWT A; #chains in the Genus database with same CATH topology 4ECQ A; 4A3M G; 4J9O A; 3R5X A; 4C2M A; 4FBU A; 1IBL H; 3PO3 G; 4A3F G; 4BBS G; 5LMN H; 1Z2N X; 4A3L G; 1KJI A; 5FLM G; 4RB3 C; 3HOY G; 3K3P A; 2QK4 A; 5DG9 A; 3LP8 A; 2VQD A; 1DIK A; 1CS0 A; 1K1S A; 4ZQI A; 4RNO A; 4APM A; 4R8U A; 3I12 A; 3Q8S B; 1KBL A; 5KFH A; 1N56 A; 2ASJ A; 4ZHQ F; 2ZDH A; 2W6M A; 2WAQ E; 3MR6 A; 3GV5 B; 2M05 A; 2HVS A; 2W8L A; 1GSA A; 3GIJ A; 5KFE A; 4RZR A; 4MV4 A; 4C5B A; 5FD5 A; 1KJ9 A; 4MTE A; 4ED7 A; 2OWO A; 4KHP H; 3VMM A; 5LL6 b; 2YCH A; 2VQF H; 4GKK H; 3N8D A; 4Q8E A; 3GIQ A; 1HR0 H; 1W96 A; 2AU0 A; 2JA6 A; 3RUP A; 4UCU A; 4X66 H; 1P8L A; 4A2A A; 4DR4 H; 3R5F A; 1TA8 A; 4Q44 A; 3V6H A; 2UXC H; 2FKL A; 5KFK A; 3FKI A; 4A2B A; 4ED1 A; 1K1Q A; 4GLX A; 2ZDG A; 2UU9 H; 3GII A; 3GTQ A; 3GTP A; 5I47 A; 5DGA A; 4AYB E; 3T5L A; 2YRX A; 4IR1 A; 2CKZ B; 1KC7 A; 1MWP A; 3RGZ A; 2XGQ A; 1W93 A; 5KT2 A; 4FM9 A; 2UVU A; 5KFB A; 4JI3 H; 2YS7 A; 3IN5 A; 4NXN H; 5LYJ F; 5EWG A; 3EPI A; 3RGX A; 5K2M A; 3N42 B; 4ECX A; 3PZP A; 2I8C A; 5FJ8 G; 2DZD A; 1V51 A; 4JUZ A; 3V4S A; 1KEE A; 4XX0 B; 1M7J A; 3Q2O A; 4JV0 A; 4EBC A; 2C2E A; 5KG7 A; 1SYX B; 3PW0 A; 5LOV F; 2JEI A; 3LML A; 4FS1 A; 4UCR A; 4WBN F; 1M0T A; 1SCU B; 3KHL A; 4DV2 H; 5KKN B; 3T5J A; 3GIP A; 3BQ0 A; 1N48 A; 3GIK A; 5J2U F; 4LH6 A; 2XC9 A; 2C22 A; 4TQS A; 3PW4 A; 5F9L A; 2ZM6 H; 4EGJ A; 2DIK A; 4Q43 A; 1N34 H; 4LF4 H; 3MR3 A; 2Q2U A; 4ECY A; 1TWC A; 3V4Z A; 4ECU A; 4LF5 H; 2UXB H; 5KFV A; 1DV2 A; 2XD4 A; 2R8I A; 1R9T A; 2JA5 G; 4ECT A; 5KT3 A; 1GLV A; 5DG7 A; 1M6V A; 4DV4 H; 5IYC G; 3H0G G; 5EWF A; 3MWE A; 1RJR A; 2R86 A; 5KFS A; 3V6J A; 4DUZ H; 3ETJ A; 3R5H A; 1FVI A; 4O4I F; 1BJT A; 1T3N A; 3HBL A; 5KFF A; 4RB1 A; 4ETS A; 3QZ7 A; 4E4T A; 3QZ8 A; 3GV8 B; 1RYR A; 4Q8F A; 1EYZ A; 2F4V H; 4JI5 H; 2W9B B; 2AQ4 A; 2UVR A; 4RNM A; 4C5C A; 3H40 A; 2E2H A; 2CQY A; 2SCU B; 1S0O A; 3L2P A; 1JX4 A; 3FKI G; 5C1P A; 2IP4 A; 2RF4 A; 4DL6 A; 4U7C A; 3JRX A; 4MV7 A; 1M0W A; 5KFM A; 3TIG A; 2JEF A; 1AUV A; 3N44 B; 3UQ8 A; 4B3M H; 3FMA A; 1VBH A; 5A2Q W; 4ECR A; 3RFC A; 1CQI B; 3SE7 A; 3GIM A; 2E5L H; 1JKJ B; 1TWF A; 5LA6 F; 4F4W A; 1VKZ A; 3GQC A; 1S0N A; 4DR6 H; 5KFY A; 3LWB A; 4M7E A; 2ASD A; 2XGP A; 3E5N A; 4YAK B; 2YZG A; 3J81 W; 2JA7 A; 2YS6 A; 2WB1 A; 1C30 A; 5EDW A; 4A3D G; 2WDT A; 3I4N G; 2C00 A; 1X9N A; 3G6X A; 1VS0 A; 2J9G A; 4DR2 H; 5KT4 A; 4DL5 A; 1Y1W A; 4IWX A; 2E2I A; 4QWE A; 4XZ3 B; 1CQJ B; 5BMV F; 4DV0 H; 3GID A; 5KFT A; 2DPI A; 4DUY H; 2IMW P; 2R93 G; 2UXD H; 1UC8 A; 4YQW A; 2ALZ A; 3ORQ A; 1WR2 A; 4ECS A; 2ASL A; 1JLL B; 2Y0S E; 3HOV G; 4ZOL F; 4GKJ H; 2NU9 B; 4I55 F; 4ED8 A; 2XCP A; 2XCA A; 4B3T H; 3KHH A; 3BAA A; 1SFO A; 2R7M A; 2UUA H; 3N43 B; 4GC7 A; 2W6N A; 1RYS A; 3CVZ A; 4A3J G; 4UCV A; 4X65 H; 4IR9 A; 4Q45 A; 3NGD A; 4TUY F; 1GGO A; 4JI1 H; 2R92 A; 1K83 A; 3C0F B; 4WD3 A; 5KFR A; 4MV6 A; 2VPQ A; 4J9L A; 1S0M A; 1O75 A; 4F4Z A; 2YL2 A; 4PQD A; 2HJW A; 2WE6 A; 2GPW A; 3KTM A; 1AN7 A; 3GLK A; 3MWD A; 2JEG A; 1J5E H; 5IWA H; 1IOV A; 4DL3 A; 4LF8 H; 2FMA A; 2R84 A; 2R7Z G; 2W7P A; 1I6U A; 1PX2 A; 3RV3 A; 4ED2 A; 1JDB B; 5KFX A; 1VBG A; 2VPS A; 4DL2 A; 5CAE B; 3BQ2 A; 3RB3 A; 2WYO A; 3H3V H; 4J0M A; 5FD6 A; 5D8D A; 5DQH A; 1RJP A; 3WNZ A; 2RGR A; 2FP4 B; 3OSN A; 1UNN C; 2W6Z A; 4O4L F; 5KFW A; 3Q8R B; 3ORR A; 5D1O B; 4G3I A; 1T94 A; 5CA0 F; 4MTD A; 3VPC A; 5KG2 A; 2P0A A; 2RDJ A; 4YR0 A; 1I7L A; 4R7R A; 5KFG A; 4J9N A; 4TQR A; 5FLX W; 1S9F A; 1B6R A; 4BWS C; 2FLN A; 4EEY A; 5JVD F; 5DG8 A; 5L1J A; 2KSW A; 3N40 P; 2B63 A; 1TWA A; 3RV4 A; 4DV3 H; 1S97 A; 4YJ3 F; 3PW2 A; 3G6Y A; 5C5J A; 2AGO A; 2V5A A; 4IRC A; 4B3R H; 5KFC A; 1FKA H; 3H4B A; 2WAQ A; 1TAE A; 1WCM A; 4JI8 H; 2J6U A; 1I7N A; 2NUA B; 3OHA A; 2VUM A; 1MZB A; 3PO2 G; 4JYA H; 5BR8 H; 1N36 H; 4ME6 A; 4RAZ A; 2FPG B; 5KG5 A; 2W6O A; 4QJF A; 2FE3 A; 2GLT A; 3KAL A; 2R7L A; 4BY1 G; 4ECZ A; 1N33 H; 2W9C B; 2R92 G; 4DR7 H; 4HNV A; 2FLL A; 3RAX A; 2WTF A; 2OLS A; 2MCT A; 2NVY A; 2XIG A; 4PWQ A; 4MV9 A; 4YBZ B; 2NU6 B; 4ED3 A; 4A93 G; 3T1Y H; 3PW7 A; 3RB4 A; 2FLP A; 4AYB A; 4O3P A; 2DLN A; 2V4Q A; 5D1O A; 4GC6 A; 2PN1 A; 1PK8 A; 1RK6 A; 1V9P A; 1BXR A; 1OWT A; 3J7A K; 4J9K A; 4DV7 H; 5JQW A; 4JV2 A; 1RK5 A; 4A3B G; 2QYZ A; 5KG3 A; 4QWD A; 2J6T A; 4JV1 A; 4EGQ A; 3N41 B; 3T5H A; 2V9W A; 4F50 A; 5C3E G; 2JA8 G; 1HNX H; 4Q0Y A; 2R85 A; 4JV5 H; 4MAM A; 2BQU A; 4YJ2 F; 3JSL A; 1SEI A; 3L4J A; 4A3K G; 5IT9 W; 2YW2 A; 4RU9 A; 1CE8 A; 2C35 B; 4QIW E; 4EFE A; 2I80 A; 2FK1 A; 3RAQ A; 5KT6 A; 4MA0 A; 1I3Q A; 3Q8Q B; 2DPJ A; 2JA6 G; 1JIH A; 4FS2 A; 3AYH B; 1KJJ A; 5FPR A; 2W8K A; 1XMO H; 1A9X A; 4LF9 H; 4EEQ A; 4LF6 H; 4UFZ A; 2VUM G; 2Q2T A; 1EZ1 A; 5DGB A; 4LSA A; 2AGQ A; 1TWG A; 3R23 A; 5C44 G; 5EZY F; 4YY3 H; 4RUA A; 2HVQ A; 2W9C A; 1HNW H; 1DGS A; 4BXX G; 2W6Q A; 3F8N A; 2R87 A; 1RJQ A; 3OSP A; 1GYF A; 2ATL A; 1E4E B; 2YYA A; 5BPH A; 3J80 W; 4C5A A; 2UVV A; 4I50 F; 4DR1 H; 1Y1V A; 1S10 A; 1B6S A; 4X62 H; 2R7N A; 1S68 A; 3PW5 A; 2HGS A; 2IBK A; 3HB9 A; 4Y8V B; 4J9M A; 3RB0 A; 1T36 A; 1EHI A; 4MV3 A; 4JI7 H; 1V4Y A; 2ZJT A; 2BR0 A; 4UCO A; 1B33 N; 3BA9 A; 3HKZ E; 5DQI A; 3K3V A; 4IAJ A; 2W70 A; 2R82 A; 2VA2 A; 4JI4 H; 1S03 G; 4JFN A; 1FJG H; 3FDS A; 4UCT A; 3M9O B; 5J2T F; 3HOZ G; 3SI8 A; 2R6F A; 4BY7 G; 2FJZ A; 2XCL A; 4ED0 A; 3OTO H; 2BQR A; 5T14 A; 1XNR H; 3GTG A; 4EYI B; 3T1H H; 5FPO A; 5KG1 A; 5KFP A; 2W9B A; 1ZQ7 A; 1E4F T; 3JRW A; 3K5I A; 5LP6 F; 4O3O A; 4YHH H; 2NVX A; 5F9N A; 1WH2 A; 3M9M B; 3TQ1 A; 2J6S A; 1Y14 B; 2R8H A; 4EBE A; 3GTJ A; 3JAM W; 2YRW A; 5KFZ A; 2PBZ A; 5KFQ A; 5L1I A; 3I4M G; 4ZI7 F; 4XYM B; 4DLK A; 1E4E A; 2W6P A; 2Y0S A; 4TV8 F; 5LXT F; 5KFA A; 4F4X A; 4O3N A; 2W9A A; 3BG5 A; 4LFB H; 2PMZ E; 4M9U A; 3CQZ A; 2VUG A; 2NU8 B; 3WO1 A; 4FU0 A; 1JDE A; 4DR5 H; 4AQY H; 2FK2 A; 2C28 A; 3EPG A; 1EUC B; 1VAJ A; 5KT7 A; 4MA5 A; 3MFI A; 5GON F; 3G8C A; 1KJQ A; 5DQG A; 4QW9 A; 3PR5 B; 1I50 A; 1ZHS A; 1IBM H; 2W7O A; 4JI6 H; 2CZG A; 5L1K A; 3BAB A; 2JA7 G; 4O2B F; 4QWA A; 3MFH A; 3BJY A; 2ZDQ A; 5JH7 F; 5LMU H; 3T5K A; 4TV9 F; 3K5H A; 5HBR B; 1HNZ H; 1Y1W G; 1L2Z A; 4JI0 H; 5KFN A; 2PMZ A; 3RB6 A; 2PVP A; 4L1K A; 3M4I A; 5L9X A; 1ZHQ A; 1BGW A; 2DWC A; 5KX5 F; 2C2R A; 4IZO A; 3H20 A; 1I94 H; 3PR4 A; 3UFX B; 4F4Y A; 4YAJ B; 3WO0 A; 3KAJ A; 5KG0 A; 2RDI A; 2JA5 A; 4RB0 A; 5EOY A; 1Z2O X; 2HVR A; 3DF7 A; 1DV1 A; 3H0G A; 4ECW A; 3ETH A; 3U9T A; 3BQ1 A; 4A3E G; 2YZM A; 2FPI B; 4MV1 A; 5KFU A; 5KFI A; 4QW8 A; 4DV5 H; 3Q1K A; 2FB9 A; 5CB4 F; 4JI2 H; 4J9S A; 3GTL A; 5IYB G; 3RJ0 A; 4J9Q A; 3GV7 B; 4O3Q A; 4RUC A; 1XMQ H; 3HOX G; 4HQ6 A; 3GTK A; 4EG0 A; 4A3I G; 5IP7 G; 3RBE A; 4X64 H; 3QFF A; 5DLF A; 3TII A; 3V6K A; 3L4K A; 1XDN A; 4K0K H; 4RNN A; 2V58 A; 5KFO A; 4U6P A; 1C3O A; 2IA6 A; 3U9S A; 1WSC A; 1GSH A; 1UC9 A; 3MR2 A; 4O3R A; 4IHJ F; 4J9P A; 2RGV A; 4UCS A; 5H80 A; 1BNC A; 4NXM H; 3MR5 A; 3JZI A; 4J9R A; 4NLG A; 2GPS A; 5D1P A; 4RAY A; 5KFD A; 4DL7 A; 2B63 G; 3G6V A; 2X0S A; 5IYD G; 3MJF A; 5CA1 F; 2R8G A; 2V4R A; 1IOW A; 4LSX A; 4O4H F; 1WCM G; 5DLG A; 3RF2 A; 5JVL A; 3EYY A; 2R93 A; 2UUB H; 4LH7 A; 5BPF A; 2YU9 A; 5C4X G; 3KXY T; 1EUD B; 4IWY A; 3M9N B; 3KHG A; 4YB8 B; 3RIZ A; 3GTM A; 4LFA H; 4QIW A; 2W71 A; 4XYL B; 4EYH B; 4LMY A; 3HOW G; 1A0I A; 2NU7 B; 4QWC A; 1JXL A; 3BA8 A; 4LFC H; 4YR3 A; 4DV1 H; 4A3G G; 4EFB A; 4I7H A; 1E4G T; 5JUM A; 2WB1 E; 4HYK A; 2OH2 A; 4MV8 A; 4HNT A; 5KT5 A; 2AGP A; 3VPB A; 1N32 H; 1GO3 E; 5C8Y F; 4OX9 H; 2R7Z A; 1ZET A; 3Q8P B; 2VR1 A; 4DL4 A; 3IG0 A; 3PN1 A; 2CW8 A; 2R8K A; 4PDB A; 4RZQ A; 2W57 A; 3MWM A; 3GIL A; 2VOB A; 5KFL A; 4YR2 A; 5KFJ A; 2VA3 A; 1B04 A; 2JEJ A; 4LF7 H; 2YZN A; 3OUU A; 3RBD A; 5EWE A; 5IP9 G; 2BQ3 A; 4ECV A; 4B3S H; 5IYZ F; 5C1O A; 3JSN A; 4R8U B; 3KHR A; 4YP3 A; 3VPD A; 4IRK A; 5KG4 A; 4ED6 A; 3HKZ A; 2R8J A; 1GSO A; 2O03 A; 4O3S A; 2R7K A; 4BBR G; 4HNU A; 2VQE H; 4IRD A; 4HR7 A; 3TIN A; 2C2D A; 2UUC H; 4CC5 A; 1TWH A; 3OUZ A; 3PVX A; 2HHH H; 3N6X A; 3TQT A; 2FK3 A; 4I4T F; 3RTX A; 1IBK H; 4QWB A; 4RB2 C; 4O2A F; 4FBT A; 4DV6 H; 4EBD A; 5L1L A; 3KAK A; 5HV6 A; 1ULZ A; 2V59 A; 3HOU G; 4A3C G; 1KJ8 A; 1AUX A; 3OHB A; 3GTO A; 2FPP B; 4DR3 H; 2CW7 A; 1Z2P X; 5KG6 A; 1Y1V G; 2UVW A; 3HXL A; 4CC6 A; 3H4D A; 1XNQ H; 2I87 A; #chains in the Genus database with same CATH homology 2FKL A; 2FJZ A; 2FK3 A; 4PQD A; 2FK1 A; 2FMA A; 2FK2 A; 1MWP A; 4JFN A; 2M05 A; 4PWQ A; 3KTM A; 1OWT A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
