2XE1A

Molecular insights into clinically isolated ompc mutants and their role in multi-drug resistance
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
354
structure length
354
Chain Sequence
AEVYNKDGNKLDLYGKVDGLHYFSDDKSVDGDQTYMRLGFKGETQVTDQLTGYGQWEYQIQGNAPESENNSWTRVAFAGLKFQDIGSFDYGRNYGVVYDVTSWTDVLPEFGGDTYGSDNFMQQRGNGFATYRNTDFFGLVDGLNFAVQYQGQNGSVSGENDPDFTGHGITNNGRKALRQNGDGVGGSITYDYEGFGVGAAVSSSKRTWDQNNTGLIGTGDRAETYTGGLKYDANNIYLAAQYTQTYNATRVGSLGWANKAQNFEAVAQYQFDFGLRPSVAYLQSKGKNLGVVAGRNYDDEDILKYVDVGATYYFNKNMSTYVDYKINLLDDNQFTRAAGINTDDIVALGLVYQF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Altered Antibiotic Transport in Ompc Mutants Isolated from a Series of Clinical Strains of Multi-Drug Resistant E. Coli.
pubmed doi rcsb
molecule tags Transport protein
source organism Escherichia coli
molecule keywords OUTER MEMBRANE PROTEIN C
total genus 105
structure length 354
sequence length 354
ec nomenclature
pdb deposition date 2010-05-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00267 Porin_1 Gram-negative porin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.160.10 Mainly Beta Beta Barrel Porin Porin 2xe1A00
4C69X 3SY7A 2ZFGA 3UU2A 2XE5A 3T0SA 1GFPA 1GFQA 2O4VA 2XE3A 2FGRA 1BT9A 5DL7A 1MPFA 3VY8X 1PHOA 1OPFA 4RJXA 4BUMX 3HW9A 1HXXA 1HXUA 3SZVA 3HWBA 4FT6A 1GFOA 3SZDA 2PORA 3VZUX 4LSEA 1GFMA 2OMFA 5PRNA 2ZLDA 3NSGA 3A2SX 3O0EA 4FOZA 4D5UA 4AUIA 3JTYA 3PORA 2Y2XA 5DL8A 1PRNA 1BH3A 4FRTA 4FMSA 2ODJA 1OSMA 4LSIA 2FGQX 7PRNA 5DL6A 3POUA 2J4UP 3UPGA 2Y0KA 2XE1A 5FVNA 3VZWX 3SY9A 5JDPA 4KR4A 2Y0HA 3SYSA 4LSHA 4GCSA 4LSFA 2PRNA 4D64A 8PRNA 3SYBA 3POQA 2XG6A 3VY9X 3POXA 4JFBA 3VZTX 5DL5A 4FRXA 3T20A 4FSPA 2Y0LA 2J1NA 4D65A 3WI5A 3K19A 3WI4A 3PRNA 2QTKA 4GCQA 3T24A 1H6S1 2K4TA 1E54A 2XE2A 6PRNA 4RJWA 4KRAA 4FSOA 1HXTA 4KR8A 3FYXA 1GFNA 4GCPA 3EMNX
chains in the Genus database with same CATH superfamily
4AFKA 4C69X 2KXPA 4AYNA 3SY7A 2F1TA 2ZFGA 4U9CA 5AFUK 3UU2A 4JCHA 2WVPA 2IWVA 4PJ0O 4C00A 2X9KA 3AA6A 2XE5A 2IWWA 3T0SA 2M07A 4Z3TA 2XTQA 1GFPA 1GFQA 2O4VA 3JCUO 2JQYA 4E1TA 2F1VA 2XE3A 4FESA 4UB8O 4AKRB 2FGRA 1BT9A 5DL7A 1MPFA 1BXWA 3HOLA 1PHOA 4FUVA 4RLCA 2YPVA 4RL9A 5G26A 3PGUA 3VY8X 3WU2O 1OPFA 1S5LO 3DZMA 3LK3B 4RJXA 3AAAB 5GV0A 4BUMX 3HW9A 1YS5A 1ZHWA 3AA1A 1Q9FA 1HXXA 1HXUA 4N75A 4O49A 3SZVA 3HWBA 4IL6O 2M06A 3RBHA 2LHFA 5T5FA 4FT6A 3KZIO 2W80C 1GFOA 4G76A 3SZDA 3GP6A 3DA3A 4GF4A 2PORA 2GE4A 4E1SA 3VZUX 3DWNA 4LSEA 1GFMA 4FZMA 5KAFO 3PQUA 4AYDC 2OMFA 3PGSA 5PRNA 4AKMA 2ZLDA 3NSGA 2KZ7A 4CTDA 5G3AA 1Q9GA 3A2SX 3AA7A 3O0EA 2JMMA 1IZNB 4FOZA 4O3WA 4O3XB 1THQA 3C5OA 4G75A 4D5UA 4AUIA 3LK2A 4XNKA 3AAEA 2KXPB 1ZHZA 3JTYA 4K3CA 3PORA 4AKRA 3AA0B 2R89A 2WJQA 2AXTO 2Y2XA 3PGRA 1T16A 5DL8A 1PRNA 4C4VA 5B5EO 1BH3A 4K3BA 5KAIO 2Y7SA 5IYUA 2WJRA 4FRTA 4N58A 4FMSA 3VE2A 2ODJA 4F4BA 1OSMA 5G39A 1ZHYA 4LSIA 3BS0A 4O3ZA 3LK41 2FGQX 2X27X 5G38A 4RLBA 7PRNA 1QJ8A 4FQEA 1QJ9A 3POUA 5DL6A 3PQSA 5D5DA 2R4NA 2MHLA 5H2FO 2J4UP 4AZLA 2Y0KA 3UPGA 4AYMC 2XE1A 3VE1A 4AYID 1P4TA 4PUXA 3PF1A 1MM5A 1ZHXA 4FZLA 3BRZA 5FVNA 2MNHA 3VZWX 4QQ1A 5GTIO 3DA4A 3SY9A 5B66O 2R4LA 2LFUA 4XNLA 5JDPA 4KR4A 2Y0HA 4O3YA 4AYEC 3SYSA 5GTHO 4LSHA 4GCSA 4LSFA 2PRNA 1IZNA 2R4OA 2F1CX 3QRAA 4D64A 8PRNA 4B61A 3SYBA 3AA6B 3POQA 2XG6A 3VY9X 3POXA 3BRYA 1ORMA 3LK3A 5ADXL 3AA0A 3AAAA 5EE2A 2KC0A 4JFBA 2ERVA 3NJTA 3VZTX 2KZ7B 5TISO 5DL5A 5ADXK 4FRXA 3T20A 3AA7B 2R4PA 4FSPA 2Y0LA 3LK42 2R8AA 1ZHTA 2J1NA 3LK2B 4N74A 4D65A 3AAEB 3KVDD 3A0HO 3QRCA 1T1LA 2K0LA 3WI5A 3K19A 3WI4A 3AA1B 3G7GA 3PRNA 2R88A 2QTKA 4GCQA 3V8UA 4C4VB 1MM4A 3T24A 1H6S1 2K4TA 4O4UA 4PR7A 1E54A 5E79O 2N2LA 2XE2A 2KDYA 3DWOX 4RJWA 1QJPA 6PRNA 4KRAA 4FSOA 1HXTA 4N59A 4UB6O 2YNKA 3A0BO 4O4XA 2N2MA 4KR8A 3FYXA 4GHBA 1G90A 2XMXA 2XTRA 1GFNA 4GCPA 5AFUL 3HOEA 3UAQA 3EMNX 3TZGA 4FZNA 2W81C
chains in the Genus database with same CATH topology
4AFKA 4C69X 2KXPA 4AYNA 3SY7A 2F1TA 2ZFGA 4U9CA 5AFUK 3UU2A 4JCHA 3AA6A 2XE5A 3T0SA 2M07A 4Z3TA 2XTQA 1GFPA 1GFQA 2O4VA 4E1TA 2F1VA 2XE3A 4FESA 4AKRB 2FGRA 1BT9A 5DL7A 1MPFA 1BXWA 3HOLA 1PHOA 4FUVA 4RLCA 2YPVA 4RL9A 5G26A 3VY8X 1OPFA 3LK3B 4RJXA 3AAAB 5GV0A 4BUMX 3HW9A 1YS5A 1ZHWA 3AA1A 1Q9FA 1HXXA 1HXUA 4O49A 3SZVA 3HWBA 2M06A 3RBHA 2LHFA 5T5FA 4FT6A 2W80C 1GFOA 4G76A 3SZDA 3GP6A 3DA3A 4GF4A 2PORA 2GE4A 4E1SA 3VZUX 4LSEA 1GFMA 4FZMA 3PQUA 4AYDC 2OMFA 5PRNA 4AKMA 2ZLDA 3NSGA 2KZ7A 1Q9GA 3A2SX 3AA7A 3O0EA 2JMMA 1IZNB 4FOZA 4O3WA 4O3XB 1THQA 3C5OA 4G75A 4D5UA 4AUIA 3LK2A 4XNKA 3AAEA 2KXPB 1ZHZA 3JTYA 3PORA 4AKRA 3AA0B 2Y2XA 5DL8A 1PRNA 1BH3A 2Y7SA 5IYUA 4N58A 4FRTA 3VE2A 4FMSA 4F4BA 2ODJA 1OSMA 1ZHYA 4LSIA 4O3ZA 3LK41 2FGQX 2X27X 4RLBA 7PRNA 1QJ8A 1QJ9A 3POUA 5DL6A 3PQSA 5D5DA 2MHLA 2J4UP 3UPGA 4AZLA 2Y0KA 4AYMC 2XE1A 3VE1A 4AYID 1P4TA 4PUXA 1MM5A 1ZHXA 4FZLA 5FVNA 3VZWX 2MNHA 4QQ1A 3DA4A 3SY9A 2LFUA 4XNLA 5JDPA 4KR4A 2Y0HA 4O3YA 4AYEC 3SYSA 4LSHA 4GCSA 4LSFA 2PRNA 1IZNA 3QRAA 4D64A 8PRNA 4B61A 3SYBA 3AA6B 3POQA 2XG6A 3VY9X 3POXA 1ORMA 3LK3A 5ADXL 3AA0A 3AAAA 5EE2A 2KC0A 4JFBA 2ERVA 3VZTX 2KZ7B 5DL5A 5ADXK 4FRXA 3T20A 3AA7B 4FSPA 2Y0LA 3LK42 1ZHTA 2J1NA 3LK2B 4D65A 3AAEB 3KVDD 3WI5A 3QRCA 2K0LA 3K19A 3WI4A 3AA1B 3G7GA 3PRNA 3V8UA 2QTKA 4GCQA 1MM4A 3T24A 1H6S1 2K4TA 4O4UA 1E54A 2N2LA 2XE2A 2KDYA 4RJWA 6PRNA 1QJPA 4KRAA 4FSOA 1HXTA 4N59A 2YNKA 4O4XA 2N2MA 4KR8A 3FYXA 4GHBA 1G90A 2XMXA 2XTRA 1GFNA 4GCPA 5AFUL 3HOEA 3UAQA 3EMNX 3TZGA 4FZNA 2W81C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4C69 X;  3SY7 A;  2ZFG A;  3UU2 A;  2XE5 A;  3T0S A;  1GFP A;  1GFQ A;  2O4V A;  2XE3 A;  2FGR A;  1BT9 A;  5DL7 A;  1MPF A;  3VY8 X;  1PHO A;  1OPF A;  4RJX A;  4BUM X;  3HW9 A;  1HXX A;  1HXU A;  3SZV A;  3HWB A;  4FT6 A;  1GFO A;  3SZD A;  2POR A;  3VZU X;  4LSE A;  1GFM A;  2OMF A;  5PRN A;  2ZLD A;  3NSG A;  3A2S X;  3O0E A;  4FOZ A;  4D5U A;  4AUI A;  3JTY A;  3POR A;  2Y2X A;  5DL8 A;  1PRN A;  1BH3 A;  4FRT A;  4FMS A;  2ODJ A;  1OSM A;  4LSI A;  2FGQ X;  7PRN A;  5DL6 A;  3POU A;  2J4U P;  3UPG A;  2Y0K A;  2XE1 A;  5FVN A;  3VZW X;  3SY9 A;  5JDP A;  4KR4 A;  2Y0H A;  3SYS A;  4LSH A;  4GCS A;  4LSF A;  2PRN A;  4D64 A;  8PRN A;  3SYB A;  3POQ A;  2XG6 A;  3VY9 X;  3POX A;  4JFB A;  3VZT X;  5DL5 A;  4FRX A;  3T20 A;  4FSP A;  2Y0L A;  2J1N A;  4D65 A;  3WI5 A;  3K19 A;  3WI4 A;  3PRN A;  2QTK A;  4GCQ A;  3T24 A;  1H6S 1;  2K4T A;  1E54 A;  2XE2 A;  6PRN A;  4RJW A;  4KRA A;  4FSO A;  1HXT A;  4KR8 A;  3FYX A;  1GFN A;  4GCP A;  3EMN X; 
#chains in the Genus database with same CATH topology
 4AFK A;  4C69 X;  2KXP A;  4AYN A;  3SY7 A;  2F1T A;  2ZFG A;  4U9C A;  5AFU K;  3UU2 A;  4JCH A;  2WVP A;  2IWV A;  4PJ0 O;  4C00 A;  2X9K A;  3AA6 A;  2XE5 A;  2IWW A;  3T0S A;  2M07 A;  4Z3T A;  2XTQ A;  1GFP A;  1GFQ A;  2O4V A;  3JCU O;  2JQY A;  4E1T A;  2F1V A;  2XE3 A;  4FES A;  4UB8 O;  4AKR B;  2FGR A;  1BT9 A;  5DL7 A;  1MPF A;  1BXW A;  3HOL A;  1PHO A;  4FUV A;  4RLC A;  2YPV A;  4RL9 A;  5G26 A;  3PGU A;  3VY8 X;  3WU2 O;  1OPF A;  1S5L O;  3DZM A;  3LK3 B;  4RJX A;  3AAA B;  5GV0 A;  4BUM X;  3HW9 A;  1YS5 A;  1ZHW A;  3AA1 A;  1Q9F A;  1HXX A;  1HXU A;  4N75 A;  4O49 A;  3SZV A;  3HWB A;  4IL6 O;  2M06 A;  3RBH A;  2LHF A;  5T5F A;  4FT6 A;  3KZI O;  2W80 C;  1GFO A;  4G76 A;  3SZD A;  3GP6 A;  3DA3 A;  4GF4 A;  2POR A;  2GE4 A;  4E1S A;  3VZU X;  3DWN A;  4LSE A;  1GFM A;  4FZM A;  5KAF O;  3PQU A;  4AYD C;  2OMF A;  3PGS A;  5PRN A;  4AKM A;  2ZLD A;  3NSG A;  2KZ7 A;  4CTD A;  5G3A A;  1Q9G A;  3A2S X;  3AA7 A;  3O0E A;  2JMM A;  1IZN B;  4FOZ A;  4O3W A;  4O3X B;  1THQ A;  3C5O A;  4G75 A;  4D5U A;  4AUI A;  3LK2 A;  4XNK A;  3AAE A;  2KXP B;  1ZHZ A;  3JTY A;  4K3C A;  3POR A;  4AKR A;  3AA0 B;  2R89 A;  2WJQ A;  2AXT O;  2Y2X A;  3PGR A;  1T16 A;  5DL8 A;  1PRN A;  4C4V A;  5B5E O;  1BH3 A;  4K3B A;  5KAI O;  2Y7S A;  5IYU A;  2WJR A;  4FRT A;  4N58 A;  4FMS A;  3VE2 A;  2ODJ A;  4F4B A;  1OSM A;  5G39 A;  1ZHY A;  4LSI A;  3BS0 A;  4O3Z A;  3LK4 1;  2FGQ X;  2X27 X;  5G38 A;  4RLB A;  7PRN A;  1QJ8 A;  4FQE A;  1QJ9 A;  3POU A;  5DL6 A;  3PQS A;  5D5D A;  2R4N A;  2MHL A;  5H2F O;  2J4U P;  4AZL A;  2Y0K A;  3UPG A;  4AYM C;  2XE1 A;  3VE1 A;  4AYI D;  1P4T A;  4PUX A;  3PF1 A;  1MM5 A;  1ZHX A;  4FZL A;  3BRZ A;  5FVN A;  2MNH A;  3VZW X;  4QQ1 A;  5GTI O;  3DA4 A;  3SY9 A;  5B66 O;  2R4L A;  2LFU A;  4XNL A;  5JDP A;  4KR4 A;  2Y0H A;  4O3Y A;  4AYE C;  3SYS A;  5GTH O;  4LSH A;  4GCS A;  4LSF A;  2PRN A;  1IZN A;  2R4O A;  2F1C X;  3QRA A;  4D64 A;  8PRN A;  4B61 A;  3SYB A;  3AA6 B;  3POQ A;  2XG6 A;  3VY9 X;  3POX A;  3BRY A;  1ORM A;  3LK3 A;  5ADX L;  3AA0 A;  3AAA A;  5EE2 A;  2KC0 A;  4JFB A;  2ERV A;  3NJT A;  3VZT X;  2KZ7 B;  5TIS O;  5DL5 A;  5ADX K;  4FRX A;  3T20 A;  3AA7 B;  2R4P A;  4FSP A;  2Y0L A;  3LK4 2;  2R8A A;  1ZHT A;  2J1N A;  3LK2 B;  4N74 A;  4D65 A;  3AAE B;  3KVD D;  3A0H O;  3QRC A;  1T1L A;  2K0L A;  3WI5 A;  3K19 A;  3WI4 A;  3AA1 B;  3G7G A;  3PRN A;  2R88 A;  2QTK A;  4GCQ A;  3V8U A;  4C4V B;  1MM4 A;  3T24 A;  1H6S 1;  2K4T A;  4O4U A;  4PR7 A;  1E54 A;  5E79 O;  2N2L A;  2XE2 A;  2KDY A;  3DWO X;  4RJW A;  1QJP A;  6PRN A;  4KRA A;  4FSO A;  1HXT A;  4N59 A;  4UB6 O;  2YNK A;  3A0B O;  4O4X A;  2N2M A;  4KR8 A;  3FYX A;  4GHB A;  1G90 A;  2XMX A;  2XTR A;  1GFN A;  4GCP A;  5AFU L;  3HOE A;  3UAQ A;  3EMN X;  3TZG A;  4FZN A;  2W81 C; 
#chains in the Genus database with same CATH homology
 4AFK A;  4C69 X;  2KXP A;  4AYN A;  3SY7 A;  2F1T A;  2ZFG A;  4U9C A;  5AFU K;  3UU2 A;  4JCH A;  3AA6 A;  2XE5 A;  3T0S A;  2M07 A;  4Z3T A;  2XTQ A;  1GFP A;  1GFQ A;  2O4V A;  4E1T A;  2F1V A;  2XE3 A;  4FES A;  4AKR B;  2FGR A;  1BT9 A;  5DL7 A;  1MPF A;  1BXW A;  3HOL A;  1PHO A;  4FUV A;  4RLC A;  2YPV A;  4RL9 A;  5G26 A;  3VY8 X;  1OPF A;  3LK3 B;  4RJX A;  3AAA B;  5GV0 A;  4BUM X;  3HW9 A;  1YS5 A;  1ZHW A;  3AA1 A;  1Q9F A;  1HXX A;  1HXU A;  4O49 A;  3SZV A;  3HWB A;  2M06 A;  3RBH A;  2LHF A;  5T5F A;  4FT6 A;  2W80 C;  1GFO A;  4G76 A;  3SZD A;  3GP6 A;  3DA3 A;  4GF4 A;  2POR A;  2GE4 A;  4E1S A;  3VZU X;  4LSE A;  1GFM A;  4FZM A;  3PQU A;  4AYD C;  2OMF A;  5PRN A;  4AKM A;  2ZLD A;  3NSG A;  2KZ7 A;  1Q9G A;  3A2S X;  3AA7 A;  3O0E A;  2JMM A;  1IZN B;  4FOZ A;  4O3W A;  4O3X B;  1THQ A;  3C5O A;  4G75 A;  4D5U A;  4AUI A;  3LK2 A;  4XNK A;  3AAE A;  2KXP B;  1ZHZ A;  3JTY A;  3POR A;  4AKR A;  3AA0 B;  2Y2X A;  5DL8 A;  1PRN A;  1BH3 A;  2Y7S A;  5IYU A;  4N58 A;  4FRT A;  3VE2 A;  4FMS A;  4F4B A;  2ODJ A;  1OSM A;  1ZHY A;  4LSI A;  4O3Z A;  3LK4 1;  2FGQ X;  2X27 X;  4RLB A;  7PRN A;  1QJ8 A;  1QJ9 A;  3POU A;  5DL6 A;  3PQS A;  5D5D A;  2MHL A;  2J4U P;  3UPG A;  4AZL A;  2Y0K A;  4AYM C;  2XE1 A;  3VE1 A;  4AYI D;  1P4T A;  4PUX A;  1MM5 A;  1ZHX A;  4FZL A;  5FVN A;  3VZW X;  2MNH A;  4QQ1 A;  3DA4 A;  3SY9 A;  2LFU A;  4XNL A;  5JDP A;  4KR4 A;  2Y0H A;  4O3Y A;  4AYE C;  3SYS A;  4LSH A;  4GCS A;  4LSF A;  2PRN A;  1IZN A;  3QRA A;  4D64 A;  8PRN A;  4B61 A;  3SYB A;  3AA6 B;  3POQ A;  2XG6 A;  3VY9 X;  3POX A;  1ORM A;  3LK3 A;  5ADX L;  3AA0 A;  3AAA A;  5EE2 A;  2KC0 A;  4JFB A;  2ERV A;  3VZT X;  2KZ7 B;  5DL5 A;  5ADX K;  4FRX A;  3T20 A;  3AA7 B;  4FSP A;  2Y0L A;  3LK4 2;  1ZHT A;  2J1N A;  3LK2 B;  4D65 A;  3AAE B;  3KVD D;  3WI5 A;  3QRC A;  2K0L A;  3K19 A;  3WI4 A;  3AA1 B;  3G7G A;  3PRN A;  3V8U A;  2QTK A;  4GCQ A;  1MM4 A;  3T24 A;  1H6S 1;  2K4T A;  4O4U A;  1E54 A;  2N2L A;  2XE2 A;  2KDY A;  4RJW A;  6PRN A;  1QJP A;  4KRA A;  4FSO A;  1HXT A;  4N59 A;  2YNK A;  4O4X A;  2N2M A;  4KR8 A;  3FYX A;  4GHB A;  1G90 A;  2XMX A;  2XTR A;  1GFN A;  4GCP A;  5AFU L;  3HOE A;  3UAQ A;  3EMN X;  3TZG A;  4FZN A;  2W81 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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