1R1JA

Structural analysis of neprilysin with various specific and potent inhibitors
Total Genus 270
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
270
sequence length
696
structure length
696
Chain Sequence
GICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Neprilysin
publication title Structural analysis of neprilysin with various specific and potent inhibitors.
pubmed doi rcsb
source organism Homo sapiens
total genus 270
structure length 696
sequence length 696
ec nomenclature ec 3.4.24.11: Neprilysin.
pdb deposition date 2003-09-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01431 Peptidase_M13 Peptidase family M13
A PF05649 Peptidase_M13_N Peptidase family M13
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1380.10 Mainly Alpha Orthogonal Bundle Neutral endopeptidase; domain 2 Neutral endopeptidase , domain2 1r1jA02
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 1r1jA01
4PKRA 1Y0VA 1IACA 1O0TA 5LABA 1ROSA 1CAQA 1ZXCA 1XFXA 3AYKA 4PKVA 1YCMA 4IJOA 2J83A 3TS4A 1DTHA 4G9LA 2JT5A 3F16A 1UEAA 5D7WA 1QUAA 1XUDA 4DF9A 3I7GA 1R55A 1BSWA 3F15A 1QIAA 3AIGA 1AYKA 2DW2A 2OXWA 3GBOA 830CA 2W0DA 1AF0A 1XURA 1XFWA 1KUFA 3AYUA 1Y8JA 1PWVA 4I35A 2J0TA 1JJ9A 1C7KA 1D8FA 1OMJA 2ERQA 1BUVM 1FBLA 1BM6A 4ON1A 1PWPA 5I2ZA 2XS4A 4GWMA 2MZIA 2USNA 3DPFA 1IADA 4FU4A 2FV5A 1ND1A 1KUIA 1CK7A 2Z2DA 4PKTA 1S4BP 2MLSA 3LKAA 966CA 1I76A 5D1TA 1CGEA 2X3AA 3OHOA 1ZS0A 1KUKA 1HOVA 3ZVSA 3EDZA 5D2BA 4H84A 1JKYA 3USNA 2JIHA 3EDGA 1SLMA 2N8RA 3KMEA 2YB9A 1SRPA 2O3EA 1UMTA 2JSDA 3TVCA 3P24A 3B92A 2O36A 4GF1A 3LJZA 3HY7A 2WO9A 1BKCE 4H2EA 3WV2A 1C8TA 2OXZA 1MMPA 3ELMA 1GKDA 1HFSA 3G5CA 4PKUA 3LQ0A 3LEAA 2OVZA 2POJA 1CXVA 1JAQA 4PKWA 3HYGA 3ZXHA 4JP4A 1BZSA 1XFZA 3Q2GA 3SHIA 1G49A 3I7IA 4JPAA 1BUDA 4DD8A 4H49A 3KHIA 1GE5A 3LQBA 1JAOA 4Q1LA 3WV3A 4GR3A 1JH1A 2OW9A 5H8XA 5I12A 3CKIA 1MMBA 4JIJA 1GO8P 2V4BA 5L79A 1YP1A 2PJTA 4GR0A 4A7BA 1OM6A 1BQQM 1QJJA 4XBHA 3TSKA 3LUMA 3LK8A 3EDIA 3LIRA 2OZRA 4H82A 2Y6CA 1G4KA 2X7MA 1AKLA 1A86A 2L0RA 3TT4A 3KWVC 2MZEA 4XM6A 1HFCA 1MMQA 2OY4A 5CUHA 3K7NA 2W14A 1MMRA 2E2DA 1FM1A 3G42A 1ZXVA 1EAKA 1OM8A 3F17A 3DSLA 1OO9A 3B2ZA 1R54A 3MA2A 4AYKA 2EROA 1OS2A 2I47A 3HBUP 4A3WA 1KUGA 2D1OA 3N2UA 1Q3AA 3EDHA 2AYKA 2DW1A 1JANA 2X3CA 1R1JA 1ZTQA 4DV8A 4QKZA 4IUWA 4I03A 3Q2HA 1KAPP 4AUOA 1UMSA 1ATLA 2A8HA 2OW1A 2QPJA 2JT6A 4L6TA 3ZUKA 3LUNA 3N2VA 5I0LA 3LJGA 1KBCA 3K7LA 3HY9A 4XM8A 1EB6A 3V96B 4R3VA 1BQOA 1PWUA 5CZMA 2YIGA 3EWJA 1B3DA 2X3BA 2OY2A 2HU6A 1QICA 1SU3A 1FLSA 4ZR5A 3P1VA 2CKIA 1RM8A 3NX7A 5I4OA 2W13A 4L63A 5CXAA 5JMYA 2W12A 2WOAA 1PWWA 1G12A 5D1SA 2DDFA 1GKCA 2FV9A 2OW0A 1O0QA 4XM7A 3RTTA 2DDYA 3KMCA 3B8ZA 4AIGA 3U1RA 3LE9A 1K7IA 1QIBA 1MNCA 1R1IA 1USNA 3LMCA 1J7NA 3LGPA 3HDAP 3DWBA 1KUHA 4WKEA 1UTZA 2XS3A 2AIGP 4GQLA 4FVLA 5BOTA 1CGLA 3HDBA 4ILWD 3O2XA 4FXYP 4JQGA 1XUCA 4WZVA 3L0TA 3BA0A 1YOUA 1GE7A 4H1QA 4L19A 5I3MA 1IABA 5BOYA 4WKIA 2W15A 2CLTA 1R1HA 1D5JA 1L6JA 2JNPA 2ERPA 4WK7A 2K9CA 4DPEA 2WO8A 1ZP5A 2OVXA 2SRTA 1BIWA 1D7XA 3VTGA 4G0DA 2D1NA 1BKCI 1Y93A 1ZVXA 1XFUA 4CTHA 1DMTA 3WV1A 1IAEA 1CGFA 1OM7A 3RTSA 3KRYA 3F18A 1Z3JA 1HTDA 3EHYA 3DPEA 2K2GA 4HMAA 3KEKA 1H71P 4GUYA 1I1IP 5I43A 1XFYA 1K7GA 2OW2A 1SATA 2OXUA 1JAPA 4JA1A 1QJIA 3O64A 1B8YA 3F1AA 4PKSA 4EFSA 1GO7P 2TCLA 3HBVP 1G05A 3DL1A 4IN9A 4HX3A 2OI0A 5D1UA 1OS9A 3L0VA 2RJPA 1C3IA 2DW0A 5L7FA 3UVCA 1G9KA 3HB2P 1JIZA 5B5PA 3VI1A 1I73A 1RMZA 1JK3A 2E3XA 1JIWP 1HY7A 1CIZA 2MLRA 5B5OA 2MZHA 4FXQA 456CA 1SMPA 1SLNA 2KRJA 1CQRA 3LIKA 1YQYA 1UTTA 1D8MA 1GXDA 5BPAA 1GE6A 4GWNA 2RJQA 4GR8A 4H3XA 3KECA 1PWQA 3OHLA 4XCTA 1IAAA 3DNGA 4J4MA 4AXQA 4H76A 1A85A 3E8RA 3KEJA 1BKCA 4PKQA 4H30A 4WF6A 1EUBA 3LILA 1IAGA 1WNIA 3F19A 3LJTA 5D3CA 1ASTA 1XFVA 1HV5A 2Y6DA 3EHXA 1K7QA
chains in the Genus database with same CATH superfamily
4PKRA 1Y0VA 1IACA 1O0TA 5LABA 1ROSA 1CAQA 1ZXCA 1XFXA 3AYKA 4PKVA 1YCMA 4IJOA 2J83A 3TS4A 1DTHA 4G9LA 2JT5A 3F16A 1UEAA 5D7WA 1QUAA 1XUDA 4DF9A 3I7GA 1R55A 1BSWA 3F15A 1QIAA 3AIGA 1AYKA 2DW2A 2OXWA 3GBOA 830CA 2W0DA 1AF0A 1XURA 3DTKA 1XFWA 1KUFA 3AYUA 1Y8JA 1PWVA 4I35A 2J0TA 1JJ9A 1C7KA 1D8FA 1OMJA 2ERQA 1BUVM 1FBLA 1BM6A 4ON1A 1PWPA 5I2ZA 2XS4A 4GWMA 2MZIA 2USNA 3DPFA 1IADA 4FU4A 2FV5A 1ND1A 1KUIA 1CK7A 2Z2DA 4PKTA 1S4BP 2MLSA 3LKAA 966CA 1I76A 5D1TA 1CGEA 2X3AA 3OHOA 1ZS0A 1KUKA 1HOVA 3ZVSA 3EDZA 5D2BA 4H84A 1JKYA 3USNA 2JIHA 3EDGA 1SLMA 2N8RA 3KMEA 2YB9A 1SRPA 2O3EA 1UMTA 2JSDA 3TVCA 3P24A 3B92A 2O36A 4GF1A 3LJZA 3HY7A 2WO9A 1BKCE 4H2EA 3WV2A 1C8TA 2OXZA 1MMPA 3ELMA 1GKDA 1HFSA 3G5CA 4PKUA 3LQ0A 3LEAA 2OVZA 2POJA 1CXVA 1JAQA 3DTIA 4PKWA 3HYGA 3ZXHA 4JP4A 1BZSA 1XFZA 3Q2GA 3SHIA 1G49A 3I7IA 4JPAA 1BUDA 4DD8A 4H49A 3KHIA 1GE5A 3LQBA 1JAOA 4Q1LA 3WV3A 4GR3A 1JH1A 2OW9A 5H8XA 5I12A 3CKIA 1MMBA 4JIJA 1GO8P 2V4BA 5L79A 1YP1A 2PJTA 4GR0A 4A7BA 1OM6A 1BQQM 1QJJA 4XBHA 3TSKA 3LUMA 3LK8A 3EDIA 3LIRA 2OZRA 4H82A 2Y6CA 1G4KA 2X7MA 1AKLA 1A86A 2L0RA 1XM5A 3TT4A 3KWVC 2MZEA 4XM6A 1HFCA 1MMQA 2OY4A 5CUHA 3K7NA 2W14A 1MMRA 2E2DA 1FM1A 3G42A 1ZXVA 1EAKA 1OM8A 3F17A 3DSLA 1OO9A 3B2ZA 1R54A 3MA2A 4AYKA 2EROA 1OS2A 2I47A 3HBUP 4A3WA 1KUGA 2D1OA 3N2UA 1Q3AA 3EDHA 2AYKA 2DW1A 1JANA 2X3CA 1R1JA 1ZTQA 4DV8A 4QKZA 4IUWA 4I03A 3Q2HA 1KAPP 4AUOA 1UMSA 1ATLA 2A8HA 2OW1A 2QPJA 2JT6A 4L6TA 3ZUKA 3LUNA 3N2VA 5I0LA 3LJGA 1KBCA 3K7LA 1TVIA 3HY9A 4XM8A 1EB6A 3V96B 4R3VA 1BQOA 1PWUA 5CZMA 2YIGA 3EWJA 1B3DA 2X3BA 2OY2A 2HU6A 1QICA 1SU3A 1FLSA 4ZR5A 3P1VA 2CKIA 1RM8A 3NX7A 5I4OA 2W13A 4L63A 5CXAA 5JMYA 2W12A 2WOAA 1PWWA 1G12A 5D1SA 2DDFA 1GKCA 2FV9A 2OW0A 1O0QA 4XM7A 3RTTA 2DDYA 3KMCA 3B8ZA 4AIGA 3U1RA 3LE9A 1K7IA 1QIBA 1MNCA 1R1IA 1USNA 3LMCA 1J7NA 3LGPA 3HDAP 3DWBA 1KUHA 4WKEA 1UTZA 2XS3A 2AIGP 4GQLA 4FVLA 5BOTA 1CGLA 3HDBA 4ILWD 3O2XA 4FXYP 4JQGA 1XUCA 4WZVA 3L0TA 3BA0A 1YOUA 1GE7A 4H1QA 4L19A 5I3MA 1IABA 5BOYA 4WKIA 2W15A 2CLTA 1R1HA 1D5JA 1L6JA 2JNPA 2ERPA 4WK7A 2K9CA 4DPEA 2WO8A 1ZP5A 2OVXA 2SRTA 1BIWA 1D7XA 3VTGA 4G0DA 2D1NA 1BKCI 1Y93A 1ZVXA 1XFUA 4CTHA 1DMTA 3WV1A 1IAEA 1CGFA 1OM7A 3RTSA 3KRYA 3F18A 1Z3JA 1HTDA 3EHYA 3DPEA 2K2GA 4HMAA 3KEKA 1H71P 4GUYA 1I1IP 5I43A 1XFYA 1K7GA 2OW2A 1OZ9A 1SATA 2OXUA 1JAPA 4JA1A 1QJIA 3O64A 1B8YA 3F1AA 4PKSA 4EFSA 1GO7P 2TCLA 3HBVP 1G05A 3DL1A 4IN9A 4HX3A 2OI0A 5D1UA 1OS9A 3L0VA 2RJPA 1C3IA 2DW0A 5L7FA 3UVCA 1G9KA 3HB2P 1JIZA 5B5PA 3VI1A 1I73A 1RMZA 3DTEA 1JK3A 2E3XA 1JIWP 1HY7A 1CIZA 2MLRA 5B5OA 2MZHA 4FXQA 456CA 1SMPA 1SLNA 2KRJA 1CQRA 4L7AA 2YUFA 3LIKA 1YQYA 1UTTA 1D8MA 1GXDA 5BPAA 1GE6A 4GWNA 2RJQA 4GR8A 4H3XA 3KECA 1PWQA 3OHLA 4XCTA 1IAAA 3DNGA 4J4MA 4AXQA 4H76A 1A85A 3E8RA 3KEJA 1BKCA 4PKQA 4H30A 4WF6A 1EUBA 1XAXA 3LILA 1IAGA 1WNIA 3F19A 3LJTA 5D3CA 1ASTA 1XFVA 1HV5A 2Y6DA 3EHXA 1K7QA
chains in the Genus database with same CATH topology
4PKRA 1Y0VA 1IACA 1O0TA 5LABA 1ROSA 1CAQA 1ZXCA 1XFXA 3AYKA 4PKVA 1YCMA 4IJOA 2J83A 3TS4A 1DTHA 4G9LA 2JT5A 3F16A 1UEAA 5D7WA 1QUAA 1XUDA 4DF9A 3I7GA 1R55A 1BSWA 3F15A 1QIAA 3AIGA 1AYKA 2DW2A 2OXWA 3GBOA 830CA 2W0DA 1AF0A 1XURA 3DTKA 1XFWA 1KUFA 3AYUA 1Y8JA 1PWVA 4I35A 2J0TA 1JJ9A 1C7KA 1D8FA 1OMJA 2ERQA 1BUVM 1FBLA 1BM6A 4ON1A 1PWPA 5I2ZA 2XS4A 4GWMA 2MZIA 2USNA 3DPFA 1IADA 4FU4A 2FV5A 1ND1A 1KUIA 1CK7A 2Z2DA 4PKTA 1S4BP 2MLSA 3LKAA 966CA 1I76A 5D1TA 1CGEA 2X3AA 3OHOA 1ZS0A 1KUKA 1HOVA 3ZVSA 3EDZA 5D2BA 4H84A 1JKYA 3USNA 2JIHA 3EDGA 1SLMA 2N8RA 3KMEA 2YB9A 1SRPA 2O3EA 1UMTA 2JSDA 3TVCA 3P24A 3B92A 2O36A 4GF1A 3LJZA 3HY7A 2WO9A 1BKCE 4H2EA 3WV2A 1C8TA 2OXZA 1MMPA 3ELMA 1GKDA 1HFSA 3G5CA 4PKUA 3LQ0A 3LEAA 2OVZA 2POJA 1CXVA 1JAQA 3DTIA 4PKWA 3HYGA 3ZXHA 4JP4A 1BZSA 1XFZA 3Q2GA 3SHIA 1G49A 3I7IA 4JPAA 1BUDA 4DD8A 4H49A 3KHIA 1GE5A 3LQBA 1JAOA 4Q1LA 3WV3A 4GR3A 1JH1A 2OW9A 5H8XA 5I12A 3CKIA 1MMBA 4JIJA 1GO8P 2V4BA 5L79A 1YP1A 2PJTA 4GR0A 4A7BA 1OM6A 1BQQM 1QJJA 4XBHA 3TSKA 3LUMA 3LK8A 3EDIA 3LIRA 2OZRA 4H82A 2Y6CA 1G4KA 2X7MA 1AKLA 1A86A 2L0RA 3TT4A 3KWVC 2MZEA 4XM6A 1HFCA 1MMQA 2OY4A 5CUHA 3K7NA 2W14A 1MMRA 2E2DA 1FM1A 3G42A 1ZXVA 1EAKA 1OM8A 3F17A 3DSLA 1OO9A 3B2ZA 1R54A 3MA2A 4AYKA 2EROA 1OS2A 2I47A 3HBUP 4A3WA 1KUGA 2D1OA 3N2UA 1Q3AA 3EDHA 2AYKA 2DW1A 1JANA 2X3CA 1R1JA 1ZTQA 4DV8A 4QKZA 4IUWA 4I03A 3Q2HA 1KAPP 4AUOA 1UMSA 1ATLA 2A8HA 2OW1A 2QPJA 2JT6A 4L6TA 3ZUKA 3LUNA 3N2VA 5I0LA 3LJGA 1KBCA 3K7LA 3HY9A 4XM8A 1EB6A 3V96B 4R3VA 1BQOA 1PWUA 5CZMA 2YIGA 3EWJA 1B3DA 2X3BA 2OY2A 2HU6A 1QICA 1SU3A 1FLSA 4ZR5A 3P1VA 2CKIA 1RM8A 3NX7A 5I4OA 2W13A 4L63A 5CXAA 5JMYA 2W12A 2WOAA 1PWWA 1G12A 5D1SA 2DDFA 1GKCA 2FV9A 2OW0A 1O0QA 4XM7A 3RTTA 2DDYA 3KMCA 3B8ZA 4AIGA 3U1RA 3LE9A 1K7IA 1QIBA 1MNCA 1R1IA 1USNA 3LMCA 1J7NA 3LGPA 3HDAP 3DWBA 1KUHA 4WKEA 1UTZA 2XS3A 2AIGP 4GQLA 4FVLA 5BOTA 1CGLA 3HDBA 4ILWD 3O2XA 4FXYP 4JQGA 1XUCA 4WZVA 3L0TA 3BA0A 1YOUA 1GE7A 4H1QA 4L19A 5I3MA 1IABA 5BOYA 4WKIA 2W15A 2CLTA 1R1HA 1D5JA 1L6JA 2JNPA 2ERPA 4WK7A 2K9CA 4DPEA 2WO8A 1ZP5A 2OVXA 2SRTA 1BIWA 1D7XA 3VTGA 4G0DA 2D1NA 1BKCI 1Y93A 1ZVXA 1XFUA 4CTHA 1DMTA 3WV1A 1IAEA 1CGFA 1OM7A 3RTSA 3KRYA 3F18A 1Z3JA 1HTDA 3EHYA 3DPEA 2K2GA 4HMAA 3KEKA 1H71P 4GUYA 1I1IP 5I43A 1XFYA 1K7GA 2OW2A 1SATA 2OXUA 1JAPA 4JA1A 1QJIA 3O64A 1B8YA 3F1AA 4PKSA 4EFSA 1GO7P 2TCLA 3HBVP 1G05A 3DL1A 4IN9A 4HX3A 2OI0A 5D1UA 1OS9A 3L0VA 2RJPA 1C3IA 2DW0A 5L7FA 3UVCA 1G9KA 3HB2P 1JIZA 5B5PA 3VI1A 1I73A 1RMZA 3DTEA 1JK3A 2E3XA 1JIWP 1HY7A 1CIZA 2MLRA 5B5OA 2MZHA 4FXQA 456CA 1SMPA 1SLNA 2KRJA 1CQRA 4L7AA 2YUFA 3LIKA 1YQYA 1UTTA 1D8MA 1GXDA 5BPAA 1GE6A 4GWNA 2RJQA 4GR8A 4H3XA 3KECA 1PWQA 3OHLA 4XCTA 1IAAA 3DNGA 4J4MA 4AXQA 4H76A 1A85A 3E8RA 3KEJA 1BKCA 4PKQA 4H30A 4WF6A 1EUBA 3LILA 1IAGA 1WNIA 3F19A 3LJTA 5D3CA 1ASTA 1XFVA 1HV5A 2Y6DA 3EHXA 1K7QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4PKR A;  1Y0V A;  1IAC A;  1O0T A;  5LAB A;  1ROS A;  1CAQ A;  1ZXC A;  1XFX A;  3AYK A;  4PKV A;  1YCM A;  4IJO A;  2J83 A;  3TS4 A;  1DTH A;  4G9L A;  2JT5 A;  3F16 A;  1UEA A;  5D7W A;  1QUA A;  1XUD A;  4DF9 A;  3I7G A;  1R55 A;  1BSW A;  3F15 A;  1QIA A;  3AIG A;  1AYK A;  2DW2 A;  2OXW A;  3GBO A;  830C A;  2W0D A;  1AF0 A;  1XUR A;  1XFW A;  1KUF A;  3AYU A;  1Y8J A;  1PWV A;  4I35 A;  2J0T A;  1JJ9 A;  1C7K A;  1D8F A;  1OMJ A;  2ERQ A;  1BUV M;  1FBL A;  1BM6 A;  4ON1 A;  1PWP A;  5I2Z A;  2XS4 A;  4GWM A;  2MZI A;  2USN A;  3DPF A;  1IAD A;  4FU4 A;  2FV5 A;  1ND1 A;  1KUI A;  1CK7 A;  2Z2D A;  4PKT A;  1S4B P;  2MLS A;  3LKA A;  966C A;  1I76 A;  5D1T A;  1CGE A;  2X3A A;  3OHO A;  1ZS0 A;  1KUK A;  1HOV A;  3ZVS A;  3EDZ A;  5D2B A;  4H84 A;  1JKY A;  3USN A;  2JIH A;  3EDG A;  1SLM A;  2N8R A;  3KME A;  2YB9 A;  1SRP A;  2O3E A;  1UMT A;  2JSD A;  3TVC A;  3P24 A;  3B92 A;  2O36 A;  4GF1 A;  3LJZ A;  3HY7 A;  2WO9 A;  1BKC E;  4H2E A;  3WV2 A;  1C8T A;  2OXZ A;  1MMP A;  3ELM A;  1GKD A;  1HFS A;  3G5C A;  4PKU A;  3LQ0 A;  3LEA A;  2OVZ A;  2POJ A;  1CXV A;  1JAQ A;  4PKW A;  3HYG A;  3ZXH A;  4JP4 A;  1BZS A;  1XFZ A;  3Q2G A;  3SHI A;  1G49 A;  3I7I A;  4JPA A;  1BUD A;  4DD8 A;  4H49 A;  3KHI A;  1GE5 A;  3LQB A;  1JAO A;  4Q1L A;  3WV3 A;  4GR3 A;  1JH1 A;  2OW9 A;  5H8X A;  5I12 A;  3CKI A;  1MMB A;  4JIJ A;  1GO8 P;  2V4B A;  5L79 A;  1YP1 A;  2PJT A;  4GR0 A;  4A7B A;  1OM6 A;  1BQQ M;  1QJJ A;  4XBH A;  3TSK A;  3LUM A;  3LK8 A;  3EDI A;  3LIR A;  2OZR A;  4H82 A;  2Y6C A;  1G4K A;  2X7M A;  1AKL A;  1A86 A;  2L0R A;  3TT4 A;  3KWV C;  2MZE A;  4XM6 A;  1HFC A;  1MMQ A;  2OY4 A;  5CUH A;  3K7N A;  2W14 A;  1MMR A;  2E2D A;  1FM1 A;  3G42 A;  1ZXV A;  1EAK A;  1OM8 A;  3F17 A;  3DSL A;  1OO9 A;  3B2Z A;  1R54 A;  3MA2 A;  4AYK A;  2ERO A;  1OS2 A;  2I47 A;  3HBU P;  4A3W A;  1KUG A;  2D1O A;  3N2U A;  1Q3A A;  3EDH A;  2AYK A;  2DW1 A;  1JAN A;  2X3C A;  1R1J A;  1ZTQ A;  4DV8 A;  4QKZ A;  4IUW A;  4I03 A;  3Q2H A;  1KAP P;  4AUO A;  1UMS A;  1ATL A;  2A8H A;  2OW1 A;  2QPJ A;  2JT6 A;  4L6T A;  3ZUK A;  3LUN A;  3N2V A;  5I0L A;  3LJG A;  1KBC A;  3K7L A;  3HY9 A;  4XM8 A;  1EB6 A;  3V96 B;  4R3V A;  1BQO A;  1PWU A;  5CZM A;  2YIG A;  3EWJ A;  1B3D A;  2X3B A;  2OY2 A;  2HU6 A;  1QIC A;  1SU3 A;  1FLS A;  4ZR5 A;  3P1V A;  2CKI A;  1RM8 A;  3NX7 A;  5I4O A;  2W13 A;  4L63 A;  5CXA A;  5JMY A;  2W12 A;  2WOA A;  1PWW A;  1G12 A;  5D1S A;  2DDF A;  1GKC A;  2FV9 A;  2OW0 A;  1O0Q A;  4XM7 A;  3RTT A;  2DDY A;  3KMC A;  3B8Z A;  4AIG A;  3U1R A;  3LE9 A;  1K7I A;  1QIB A;  1MNC A;  1R1I A;  1USN A;  3LMC A;  1J7N A;  3LGP A;  3HDA P;  3DWB A;  1KUH A;  4WKE A;  1UTZ A;  2XS3 A;  2AIG P;  4GQL A;  4FVL A;  5BOT A;  1CGL A;  3HDB A;  4ILW D;  3O2X A;  4FXY P;  4JQG A;  1XUC A;  4WZV A;  3L0T A;  3BA0 A;  1YOU A;  1GE7 A;  4H1Q A;  4L19 A;  5I3M A;  1IAB A;  5BOY A;  4WKI A;  2W15 A;  2CLT A;  1R1H A;  1D5J A;  1L6J A;  2JNP A;  2ERP A;  4WK7 A;  2K9C A;  4DPE A;  2WO8 A;  1ZP5 A;  2OVX A;  2SRT A;  1BIW A;  1D7X A;  3VTG A;  4G0D A;  2D1N A;  1BKC I;  1Y93 A;  1ZVX A;  1XFU A;  4CTH A;  1DMT A;  3WV1 A;  1IAE A;  1CGF A;  1OM7 A;  3RTS A;  3KRY A;  3F18 A;  1Z3J A;  1HTD A;  3EHY A;  3DPE A;  2K2G A;  4HMA A;  3KEK A;  1H71 P;  4GUY A;  1I1I P;  5I43 A;  1XFY A;  1K7G A;  2OW2 A;  1SAT A;  2OXU A;  1JAP A;  4JA1 A;  1QJI A;  3O64 A;  1B8Y A;  3F1A A;  4PKS A;  4EFS A;  1GO7 P;  2TCL A;  3HBV P;  1G05 A;  3DL1 A;  4IN9 A;  4HX3 A;  2OI0 A;  5D1U A;  1OS9 A;  3L0V A;  2RJP A;  1C3I A;  2DW0 A;  5L7F A;  3UVC A;  1G9K A;  3HB2 P;  1JIZ A;  5B5P A;  3VI1 A;  1I73 A;  1RMZ A;  1JK3 A;  2E3X A;  1JIW P;  1HY7 A;  1CIZ A;  2MLR A;  5B5O A;  2MZH A;  4FXQ A;  456C A;  1SMP A;  1SLN A;  2KRJ A;  1CQR A;  3LIK A;  1YQY A;  1UTT A;  1D8M A;  1GXD A;  5BPA A;  1GE6 A;  4GWN A;  2RJQ A;  4GR8 A;  4H3X A;  3KEC A;  1PWQ A;  3OHL A;  4XCT A;  1IAA A;  3DNG A;  4J4M A;  4AXQ A;  4H76 A;  1A85 A;  3E8R A;  3KEJ A;  1BKC A;  4PKQ A;  4H30 A;  4WF6 A;  1EUB A;  3LIL A;  1IAG A;  1WNI A;  3F19 A;  3LJT A;  5D3C A;  1AST A;  1XFV A;  1HV5 A;  2Y6D A;  3EHX A;  1K7Q A; 
#chains in the Genus database with same CATH topology
 4PKR A;  1Y0V A;  1IAC A;  1O0T A;  5LAB A;  1ROS A;  1CAQ A;  1ZXC A;  1XFX A;  3AYK A;  4PKV A;  1YCM A;  4IJO A;  2J83 A;  3TS4 A;  1DTH A;  4G9L A;  2JT5 A;  3F16 A;  1UEA A;  5D7W A;  1QUA A;  1XUD A;  4DF9 A;  3I7G A;  1R55 A;  1BSW A;  3F15 A;  1QIA A;  3AIG A;  1AYK A;  2DW2 A;  2OXW A;  3GBO A;  830C A;  2W0D A;  1AF0 A;  1XUR A;  3DTK A;  1XFW A;  1KUF A;  3AYU A;  1Y8J A;  1PWV A;  4I35 A;  2J0T A;  1JJ9 A;  1C7K A;  1D8F A;  1OMJ A;  2ERQ A;  1BUV M;  1FBL A;  1BM6 A;  4ON1 A;  1PWP A;  5I2Z A;  2XS4 A;  4GWM A;  2MZI A;  2USN A;  3DPF A;  1IAD A;  4FU4 A;  2FV5 A;  1ND1 A;  1KUI A;  1CK7 A;  2Z2D A;  4PKT A;  1S4B P;  2MLS A;  3LKA A;  966C A;  1I76 A;  5D1T A;  1CGE A;  2X3A A;  3OHO A;  1ZS0 A;  1KUK A;  1HOV A;  3ZVS A;  3EDZ A;  5D2B A;  4H84 A;  1JKY A;  3USN A;  2JIH A;  3EDG A;  1SLM A;  2N8R A;  3KME A;  2YB9 A;  1SRP A;  2O3E A;  1UMT A;  2JSD A;  3TVC A;  3P24 A;  3B92 A;  2O36 A;  4GF1 A;  3LJZ A;  3HY7 A;  2WO9 A;  1BKC E;  4H2E A;  3WV2 A;  1C8T A;  2OXZ A;  1MMP A;  3ELM A;  1GKD A;  1HFS A;  3G5C A;  4PKU A;  3LQ0 A;  3LEA A;  2OVZ A;  2POJ A;  1CXV A;  1JAQ A;  3DTI A;  4PKW A;  3HYG A;  3ZXH A;  4JP4 A;  1BZS A;  1XFZ A;  3Q2G A;  3SHI A;  1G49 A;  3I7I A;  4JPA A;  1BUD A;  4DD8 A;  4H49 A;  3KHI A;  1GE5 A;  3LQB A;  1JAO A;  4Q1L A;  3WV3 A;  4GR3 A;  1JH1 A;  2OW9 A;  5H8X A;  5I12 A;  3CKI A;  1MMB A;  4JIJ A;  1GO8 P;  2V4B A;  5L79 A;  1YP1 A;  2PJT A;  4GR0 A;  4A7B A;  1OM6 A;  1BQQ M;  1QJJ A;  4XBH A;  3TSK A;  3LUM A;  3LK8 A;  3EDI A;  3LIR A;  2OZR A;  4H82 A;  2Y6C A;  1G4K A;  2X7M A;  1AKL A;  1A86 A;  2L0R A;  1XM5 A;  3TT4 A;  3KWV C;  2MZE A;  4XM6 A;  1HFC A;  1MMQ A;  2OY4 A;  5CUH A;  3K7N A;  2W14 A;  1MMR A;  2E2D A;  1FM1 A;  3G42 A;  1ZXV A;  1EAK A;  1OM8 A;  3F17 A;  3DSL A;  1OO9 A;  3B2Z A;  1R54 A;  3MA2 A;  4AYK A;  2ERO A;  1OS2 A;  2I47 A;  3HBU P;  4A3W A;  1KUG A;  2D1O A;  3N2U A;  1Q3A A;  3EDH A;  2AYK A;  2DW1 A;  1JAN A;  2X3C A;  1R1J A;  1ZTQ A;  4DV8 A;  4QKZ A;  4IUW A;  4I03 A;  3Q2H A;  1KAP P;  4AUO A;  1UMS A;  1ATL A;  2A8H A;  2OW1 A;  2QPJ A;  2JT6 A;  4L6T A;  3ZUK A;  3LUN A;  3N2V A;  5I0L A;  3LJG A;  1KBC A;  3K7L A;  1TVI A;  3HY9 A;  4XM8 A;  1EB6 A;  3V96 B;  4R3V A;  1BQO A;  1PWU A;  5CZM A;  2YIG A;  3EWJ A;  1B3D A;  2X3B A;  2OY2 A;  2HU6 A;  1QIC A;  1SU3 A;  1FLS A;  4ZR5 A;  3P1V A;  2CKI A;  1RM8 A;  3NX7 A;  5I4O A;  2W13 A;  4L63 A;  5CXA A;  5JMY A;  2W12 A;  2WOA A;  1PWW A;  1G12 A;  5D1S A;  2DDF A;  1GKC A;  2FV9 A;  2OW0 A;  1O0Q A;  4XM7 A;  3RTT A;  2DDY A;  3KMC A;  3B8Z A;  4AIG A;  3U1R A;  3LE9 A;  1K7I A;  1QIB A;  1MNC A;  1R1I A;  1USN A;  3LMC A;  1J7N A;  3LGP A;  3HDA P;  3DWB A;  1KUH A;  4WKE A;  1UTZ A;  2XS3 A;  2AIG P;  4GQL A;  4FVL A;  5BOT A;  1CGL A;  3HDB A;  4ILW D;  3O2X A;  4FXY P;  4JQG A;  1XUC A;  4WZV A;  3L0T A;  3BA0 A;  1YOU A;  1GE7 A;  4H1Q A;  4L19 A;  5I3M A;  1IAB A;  5BOY A;  4WKI A;  2W15 A;  2CLT A;  1R1H A;  1D5J A;  1L6J A;  2JNP A;  2ERP A;  4WK7 A;  2K9C A;  4DPE A;  2WO8 A;  1ZP5 A;  2OVX A;  2SRT A;  1BIW A;  1D7X A;  3VTG A;  4G0D A;  2D1N A;  1BKC I;  1Y93 A;  1ZVX A;  1XFU A;  4CTH A;  1DMT A;  3WV1 A;  1IAE A;  1CGF A;  1OM7 A;  3RTS A;  3KRY A;  3F18 A;  1Z3J A;  1HTD A;  3EHY A;  3DPE A;  2K2G A;  4HMA A;  3KEK A;  1H71 P;  4GUY A;  1I1I P;  5I43 A;  1XFY A;  1K7G A;  2OW2 A;  1OZ9 A;  1SAT A;  2OXU A;  1JAP A;  4JA1 A;  1QJI A;  3O64 A;  1B8Y A;  3F1A A;  4PKS A;  4EFS A;  1GO7 P;  2TCL A;  3HBV P;  1G05 A;  3DL1 A;  4IN9 A;  4HX3 A;  2OI0 A;  5D1U A;  1OS9 A;  3L0V A;  2RJP A;  1C3I A;  2DW0 A;  5L7F A;  3UVC A;  1G9K A;  3HB2 P;  1JIZ A;  5B5P A;  3VI1 A;  1I73 A;  1RMZ A;  3DTE A;  1JK3 A;  2E3X A;  1JIW P;  1HY7 A;  1CIZ A;  2MLR A;  5B5O A;  2MZH A;  4FXQ A;  456C A;  1SMP A;  1SLN A;  2KRJ A;  1CQR A;  4L7A A;  2YUF A;  3LIK A;  1YQY A;  1UTT A;  1D8M A;  1GXD A;  5BPA A;  1GE6 A;  4GWN A;  2RJQ A;  4GR8 A;  4H3X A;  3KEC A;  1PWQ A;  3OHL A;  4XCT A;  1IAA A;  3DNG A;  4J4M A;  4AXQ A;  4H76 A;  1A85 A;  3E8R A;  3KEJ A;  1BKC A;  4PKQ A;  4H30 A;  4WF6 A;  1EUB A;  1XAX A;  3LIL A;  1IAG A;  1WNI A;  3F19 A;  3LJT A;  5D3C A;  1AST A;  1XFV A;  1HV5 A;  2Y6D A;  3EHX A;  1K7Q A; 
#chains in the Genus database with same CATH homology
 4PKR A;  1Y0V A;  1IAC A;  1O0T A;  5LAB A;  1ROS A;  1CAQ A;  1ZXC A;  1XFX A;  3AYK A;  4PKV A;  1YCM A;  4IJO A;  2J83 A;  3TS4 A;  1DTH A;  4G9L A;  2JT5 A;  3F16 A;  1UEA A;  5D7W A;  1QUA A;  1XUD A;  4DF9 A;  3I7G A;  1R55 A;  1BSW A;  3F15 A;  1QIA A;  3AIG A;  1AYK A;  2DW2 A;  2OXW A;  3GBO A;  830C A;  2W0D A;  1AF0 A;  1XUR A;  3DTK A;  1XFW A;  1KUF A;  3AYU A;  1Y8J A;  1PWV A;  4I35 A;  2J0T A;  1JJ9 A;  1C7K A;  1D8F A;  1OMJ A;  2ERQ A;  1BUV M;  1FBL A;  1BM6 A;  4ON1 A;  1PWP A;  5I2Z A;  2XS4 A;  4GWM A;  2MZI A;  2USN A;  3DPF A;  1IAD A;  4FU4 A;  2FV5 A;  1ND1 A;  1KUI A;  1CK7 A;  2Z2D A;  4PKT A;  1S4B P;  2MLS A;  3LKA A;  966C A;  1I76 A;  5D1T A;  1CGE A;  2X3A A;  3OHO A;  1ZS0 A;  1KUK A;  1HOV A;  3ZVS A;  3EDZ A;  5D2B A;  4H84 A;  1JKY A;  3USN A;  2JIH A;  3EDG A;  1SLM A;  2N8R A;  3KME A;  2YB9 A;  1SRP A;  2O3E A;  1UMT A;  2JSD A;  3TVC A;  3P24 A;  3B92 A;  2O36 A;  4GF1 A;  3LJZ A;  3HY7 A;  2WO9 A;  1BKC E;  4H2E A;  3WV2 A;  1C8T A;  2OXZ A;  1MMP A;  3ELM A;  1GKD A;  1HFS A;  3G5C A;  4PKU A;  3LQ0 A;  3LEA A;  2OVZ A;  2POJ A;  1CXV A;  1JAQ A;  3DTI A;  4PKW A;  3HYG A;  3ZXH A;  4JP4 A;  1BZS A;  1XFZ A;  3Q2G A;  3SHI A;  1G49 A;  3I7I A;  4JPA A;  1BUD A;  4DD8 A;  4H49 A;  3KHI A;  1GE5 A;  3LQB A;  1JAO A;  4Q1L A;  3WV3 A;  4GR3 A;  1JH1 A;  2OW9 A;  5H8X A;  5I12 A;  3CKI A;  1MMB A;  4JIJ A;  1GO8 P;  2V4B A;  5L79 A;  1YP1 A;  2PJT A;  4GR0 A;  4A7B A;  1OM6 A;  1BQQ M;  1QJJ A;  4XBH A;  3TSK A;  3LUM A;  3LK8 A;  3EDI A;  3LIR A;  2OZR A;  4H82 A;  2Y6C A;  1G4K A;  2X7M A;  1AKL A;  1A86 A;  2L0R A;  3TT4 A;  3KWV C;  2MZE A;  4XM6 A;  1HFC A;  1MMQ A;  2OY4 A;  5CUH A;  3K7N A;  2W14 A;  1MMR A;  2E2D A;  1FM1 A;  3G42 A;  1ZXV A;  1EAK A;  1OM8 A;  3F17 A;  3DSL A;  1OO9 A;  3B2Z A;  1R54 A;  3MA2 A;  4AYK A;  2ERO A;  1OS2 A;  2I47 A;  3HBU P;  4A3W A;  1KUG A;  2D1O A;  3N2U A;  1Q3A A;  3EDH A;  2AYK A;  2DW1 A;  1JAN A;  2X3C A;  1R1J A;  1ZTQ A;  4DV8 A;  4QKZ A;  4IUW A;  4I03 A;  3Q2H A;  1KAP P;  4AUO A;  1UMS A;  1ATL A;  2A8H A;  2OW1 A;  2QPJ A;  2JT6 A;  4L6T A;  3ZUK A;  3LUN A;  3N2V A;  5I0L A;  3LJG A;  1KBC A;  3K7L A;  3HY9 A;  4XM8 A;  1EB6 A;  3V96 B;  4R3V A;  1BQO A;  1PWU A;  5CZM A;  2YIG A;  3EWJ A;  1B3D A;  2X3B A;  2OY2 A;  2HU6 A;  1QIC A;  1SU3 A;  1FLS A;  4ZR5 A;  3P1V A;  2CKI A;  1RM8 A;  3NX7 A;  5I4O A;  2W13 A;  4L63 A;  5CXA A;  5JMY A;  2W12 A;  2WOA A;  1PWW A;  1G12 A;  5D1S A;  2DDF A;  1GKC A;  2FV9 A;  2OW0 A;  1O0Q A;  4XM7 A;  3RTT A;  2DDY A;  3KMC A;  3B8Z A;  4AIG A;  3U1R A;  3LE9 A;  1K7I A;  1QIB A;  1MNC A;  1R1I A;  1USN A;  3LMC A;  1J7N A;  3LGP A;  3HDA P;  3DWB A;  1KUH A;  4WKE A;  1UTZ A;  2XS3 A;  2AIG P;  4GQL A;  4FVL A;  5BOT A;  1CGL A;  3HDB A;  4ILW D;  3O2X A;  4FXY P;  4JQG A;  1XUC A;  4WZV A;  3L0T A;  3BA0 A;  1YOU A;  1GE7 A;  4H1Q A;  4L19 A;  5I3M A;  1IAB A;  5BOY A;  4WKI A;  2W15 A;  2CLT A;  1R1H A;  1D5J A;  1L6J A;  2JNP A;  2ERP A;  4WK7 A;  2K9C A;  4DPE A;  2WO8 A;  1ZP5 A;  2OVX A;  2SRT A;  1BIW A;  1D7X A;  3VTG A;  4G0D A;  2D1N A;  1BKC I;  1Y93 A;  1ZVX A;  1XFU A;  4CTH A;  1DMT A;  3WV1 A;  1IAE A;  1CGF A;  1OM7 A;  3RTS A;  3KRY A;  3F18 A;  1Z3J A;  1HTD A;  3EHY A;  3DPE A;  2K2G A;  4HMA A;  3KEK A;  1H71 P;  4GUY A;  1I1I P;  5I43 A;  1XFY A;  1K7G A;  2OW2 A;  1SAT A;  2OXU A;  1JAP A;  4JA1 A;  1QJI A;  3O64 A;  1B8Y A;  3F1A A;  4PKS A;  4EFS A;  1GO7 P;  2TCL A;  3HBV P;  1G05 A;  3DL1 A;  4IN9 A;  4HX3 A;  2OI0 A;  5D1U A;  1OS9 A;  3L0V A;  2RJP A;  1C3I A;  2DW0 A;  5L7F A;  3UVC A;  1G9K A;  3HB2 P;  1JIZ A;  5B5P A;  3VI1 A;  1I73 A;  1RMZ A;  3DTE A;  1JK3 A;  2E3X A;  1JIW P;  1HY7 A;  1CIZ A;  2MLR A;  5B5O A;  2MZH A;  4FXQ A;  456C A;  1SMP A;  1SLN A;  2KRJ A;  1CQR A;  4L7A A;  2YUF A;  3LIK A;  1YQY A;  1UTT A;  1D8M A;  1GXD A;  5BPA A;  1GE6 A;  4GWN A;  2RJQ A;  4GR8 A;  4H3X A;  3KEC A;  1PWQ A;  3OHL A;  4XCT A;  1IAA A;  3DNG A;  4J4M A;  4AXQ A;  4H76 A;  1A85 A;  3E8R A;  3KEJ A;  1BKC A;  4PKQ A;  4H30 A;  4WF6 A;  1EUB A;  3LIL A;  1IAG A;  1WNI A;  3F19 A;  3LJT A;  5D3C A;  1AST A;  1XFV A;  1HV5 A;  2Y6D A;  3EHX A;  1K7Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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