3LE9A

Crystal structure of the catalytic domain of tace with indazolinone-phenyl-hydantoin inhibitor
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
257
structure length
251
Chain Sequence
PDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Disintegrin and metalloproteinase domain-containing protein
publication title Biaryl substituted hydantoin compounds as TACE inhibitors.
pubmed doi rcsb
source organism Homo sapiens
total genus 81
structure length 251
sequence length 257
chains with identical sequence B
ec nomenclature ec 3.4.24.86: ADAM 17 endopeptidase.
pdb deposition date 2010-01-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13688 Reprolysin_5 Metallo-peptidase family M12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3le9A00
2OY2A 1USNA 4PKSA 2AYKA 1CIZA 1CAQA 2I47A 3HYGA 1Y8JA 4WK7A 1ZXCA 1ZP5A 5LABA 1BQQM 1MMBA 2X3CA 2DW1A 1SRPA 1JAQA 2ERQA 4IUWA 3GBOA 3MA2A 3TVCA 1RMZA 3O2XA 4AYKA 5CZMA 4JA1A 5I2ZA 2DW2A 2W15A 3LIRA 3DL1A 5H8XA 3WV1A 3EDHA 2JT6A 2PJTA 1YP1A 1EB6A 4DF9A 3USNA 1ND1A 3I7IA 1IAEA 1XURA 4I03A 4AIGA 3WV3A 4PKVA 4EFSA 4AXQA 4PKTA 1BKCI 1CGLA 5D2BA 3AIGA 1FBLA 1R54A 3VTGA 2JIHA 4L63A 456CA 5BOYA 1D5JA 2CLTA 966CA 1I1IP 2W0DA 2DW0A 2Y6DA 2X3AA 2O3EA 3BA0A 1HV5A 1IADA 5B5PA 1BKCA 1QIAA 5I0LA 3F17A 4I35A 3KECA 1IAAA 1C3IA 2J83A 4ZR5A 1KUIA 2FV9A 1ZXVA 3TT4A 3Q2GA 3HY9A 3KEKA 2MZIA 1MNCA 3DPEA 4H30A 3LE9A 1GE5A 1FM1A 3EHXA 4GR0A 1BKCE 1A86A 1R1IA 1BZSA 4FU4A 5BPAA 1S4BP 1UMSA 3RTSA 2OVZA 2K2GA 3OHLA 3B92A 1R55A 3DNGA 1D8MA 1XUDA 1JIZA 4H82A 1B8YA 1AF0A 1Y0VA 3EDGA 2WOAA 1KAPP 2W14A 4PKWA 1QUAA 3KWVC 4GWNA 1AYKA 1O0TA 4QKZA 4JIJA 5D7WA 1OM6A 3K7NA 1XFUA 2USNA 1G05A 3EDZA 5D1SA 1QJJA 4H76A 2OI0A 3Q2HA 1CGEA 4GF1A 1QJIA 3HBUP 1JAPA 2OW2A 1OM8A 1KBCA 1ZVXA 3DWBA 1D7XA 3LJZA 2V4BA 3KEJA 2WO8A 4WKIA 1YQYA 2O36A 3ZVSA 4H3XA 4PKUA 3LKAA 1GKDA 1UMTA 2XS3A 1G4KA 2L0RA 3G42A 4AUOA 3B8ZA 2OW9A 3ZXHA 1OS2A 2AIGP 3AYKA 4L6TA 1YOUA 2POJA 4R3VA 1L6JA 1O0QA 1XFVA 5L79A 5CUHA 4DPEA 3N2VA 830CA 1R1HA 3HDBA 2RJPA 4PKRA 5D1UA 3AYUA 1SATA 1ROSA 4H1QA 4XBHA 1KUFA 1C8TA 4CTHA 1BUVM 4PKQA 5CXAA 4G9LA 2SRTA 1CGFA 1GE6A 4WKEA 4WF6A 4A3WA 2E2DA 1D8FA 3F18A 1HTDA 4H2EA 3HDAP 1EAKA 1XFZA 3L0VA 1JJ9A 3NX7A 2OXWA 1MMPA 1JANA 2OW1A 1XFWA 5I3MA 2W13A 1QIBA 2XS4A 1DTHA 5BOTA 2DDYA 4XM8A 3ZUKA 3P24A 3EWJA 4HMAA 1KUKA 1GXDA 1Q3AA 1PWQA 1OO9A 2EROA 4GUYA 1J7NA 1XFXA 3KMCA 3V96B 3LMCA 1BM6A 1HOVA 1SMPA 1CQRA 2J0TA 1K7GA 3B2ZA 4G0DA 3DPFA 4ILWD 2JNPA 1BSWA 3WV2A 1CXVA 2RJQA 1EUBA 3F16A 4FXQA 2Z2DA 3LIKA 3LILA 3LUMA 3L0TA 2OW0A 4H49A 1G49A 5D3CA 1SU3A 1K7IA 1BUDA 2JT5A 2Y6CA 1AKLA 1ZTQA 2WO9A 2FV5A 1IAGA 4XCTA 1ATLA 3VI1A 3TSKA 1HFSA 1IABA 1HY7A 4Q1LA 2OVXA 3E8RA 1H71P 1PWPA 2CKIA 1YCMA 1OM7A 2MLSA 4IN9A 2OY4A 1PWUA 1KUHA 4GQLA 1WNIA 5I12A 3LGPA 3KMEA 1CK7A 4XM7A 5JMYA 3O64A 1PWVA 3N2UA 4H84A 4IJOA 5I43A 3TS4A 1G9KA 2DDFA 3F15A 3LUNA 1XUCA 3LQBA 4JP4A 1FLSA 1MMRA 4ON1A 3LK8A 3F19A 3OHOA 4GR8A 1C7KA 2JSDA 2QPJA 3KRYA 1OMJA 2A8HA 1Z3JA 4J4MA 2K9CA 4FXYP 3ELMA 5B5OA 1JKYA 1G12A 2E3XA 3I7GA 3SHIA 1DMTA 2MZHA 2N8RA 5D1TA 1UEAA 2YIGA 3G5CA 1GO7P 1GE7A 1PWWA 1BIWA 3RTTA 3HBVP 3K7LA 3HY7A 3UVCA 1HFCA 2X3BA 4L19A 4XM6A 1JH1A 2HU6A 1UTTA 4DD8A 4GWMA 4DV8A 4JQGA 1R1JA 2MZEA 1BQOA 1RM8A 2OXZA 4HX3A 1Y93A 3EHYA 4WZVA 1QICA 4JPAA 5L7FA 3P1VA 3LJGA 1B3DA 3KHIA 3U1RA 1A85A 2OXUA 1JIWP 4GR3A 3HB2P 4A7BA 2X7MA 2MLRA 1XFYA 3CKIA 2ERPA 1K7QA 1IACA 2KRJA 3F1AA 1GO8P 1JK3A 1ASTA 1GKCA 1ZS0A 2D1NA 1SLNA 1SLMA 2D1OA 1I73A 3LJTA 3LQ0A 1I76A 2TCLA 1OS9A 3DSLA 3EDIA 1UTZA 4FVLA 5I4OA 1KUGA 2W12A 1MMQA 3LEAA 2YB9A 1JAOA 2OZRA
chains in the Genus database with same CATH superfamily
2OY2A 1USNA 4PKSA 2AYKA 1CIZA 1CAQA 2I47A 3HYGA 1Y8JA 4WK7A 1ZXCA 1ZP5A 5LABA 1BQQM 1MMBA 2X3CA 2DW1A 1SRPA 1JAQA 2ERQA 4IUWA 3GBOA 3MA2A 3TVCA 1RMZA 3O2XA 4AYKA 5CZMA 4JA1A 5I2ZA 2DW2A 2W15A 3LIRA 3DL1A 5H8XA 3WV1A 3EDHA 2JT6A 2PJTA 1YP1A 1EB6A 4DF9A 3USNA 1ND1A 3I7IA 1IAEA 1XURA 4I03A 4AIGA 3WV3A 4PKVA 4EFSA 4AXQA 4PKTA 1BKCI 1CGLA 5D2BA 3AIGA 1FBLA 1R54A 3VTGA 2JIHA 4L63A 456CA 5BOYA 1D5JA 1XM5A 2CLTA 966CA 1I1IP 2W0DA 2DW0A 2Y6DA 2X3AA 2O3EA 3BA0A 1HV5A 1IADA 5B5PA 1BKCA 1QIAA 5I0LA 3F17A 4I35A 3KECA 1IAAA 1C3IA 2J83A 4ZR5A 1KUIA 2FV9A 1ZXVA 3TT4A 3Q2GA 3HY9A 3KEKA 2MZIA 1MNCA 3DPEA 4H30A 3LE9A 1GE5A 3DTKA 1FM1A 3EHXA 4GR0A 1BKCE 1A86A 1R1IA 1BZSA 4FU4A 5BPAA 1S4BP 1UMSA 3RTSA 2OVZA 2K2GA 3OHLA 2YUFA 3B92A 1R55A 3DNGA 1D8MA 1XUDA 1JIZA 4H82A 1B8YA 1AF0A 1Y0VA 3EDGA 2WOAA 1KAPP 2W14A 4PKWA 1QUAA 3KWVC 4GWNA 1AYKA 1O0TA 4QKZA 4JIJA 5D7WA 1OM6A 3K7NA 1XFUA 2USNA 1G05A 3EDZA 5D1SA 1QJJA 4H76A 2OI0A 3Q2HA 1CGEA 4GF1A 1QJIA 3HBUP 1JAPA 2OW2A 1OM8A 1KBCA 1ZVXA 3DWBA 1D7XA 3LJZA 2V4BA 3KEJA 2WO8A 4WKIA 1YQYA 2O36A 3ZVSA 4H3XA 4PKUA 3LKAA 1GKDA 1UMTA 2XS3A 1G4KA 2L0RA 3G42A 4AUOA 3B8ZA 2OW9A 3ZXHA 1OS2A 2AIGP 3AYKA 4L6TA 1YOUA 2POJA 4R3VA 1L6JA 1O0QA 1XFVA 3DTEA 5L79A 5CUHA 4DPEA 3N2VA 830CA 1R1HA 3HDBA 2RJPA 4PKRA 5D1UA 3AYUA 1SATA 1ROSA 4H1QA 4XBHA 1KUFA 1C8TA 4CTHA 1BUVM 4PKQA 5CXAA 4G9LA 2SRTA 1CGFA 1GE6A 4WKEA 4WF6A 4A3WA 2E2DA 1D8FA 3F18A 1HTDA 4H2EA 3HDAP 1EAKA 1XFZA 3L0VA 1JJ9A 3NX7A 2OXWA 1MMPA 1JANA 2OW1A 1XFWA 5I3MA 2W13A 1QIBA 2XS4A 1DTHA 5BOTA 2DDYA 4XM8A 3ZUKA 3P24A 3EWJA 4HMAA 1KUKA 1GXDA 1Q3AA 1PWQA 1OO9A 2EROA 4GUYA 1J7NA 1XFXA 3KMCA 3V96B 3LMCA 1BM6A 1HOVA 1SMPA 1CQRA 2J0TA 1K7GA 3B2ZA 4G0DA 3DPFA 4ILWD 2JNPA 1BSWA 3WV2A 1CXVA 2RJQA 1EUBA 3F16A 4FXQA 2Z2DA 3LIKA 3LILA 3LUMA 3L0TA 2OW0A 4H49A 1G49A 5D3CA 1SU3A 1K7IA 1BUDA 2JT5A 2Y6CA 1AKLA 1ZTQA 2WO9A 2FV5A 1IAGA 4XCTA 1ATLA 3VI1A 3TSKA 1OZ9A 1HFSA 1IABA 1HY7A 4Q1LA 2OVXA 3E8RA 1H71P 1PWPA 2CKIA 1YCMA 1OM7A 2MLSA 4IN9A 2OY4A 1PWUA 3DTIA 1KUHA 4GQLA 1WNIA 5I12A 3LGPA 1XAXA 3KMEA 1CK7A 4XM7A 5JMYA 3O64A 1PWVA 3N2UA 4H84A 4IJOA 5I43A 3TS4A 1G9KA 2DDFA 3F15A 3LUNA 1TVIA 1XUCA 3LQBA 4JP4A 1FLSA 1MMRA 4ON1A 3LK8A 3F19A 3OHOA 4GR8A 1C7KA 2JSDA 2QPJA 3KRYA 1OMJA 2A8HA 1Z3JA 4J4MA 2K9CA 4FXYP 3ELMA 5B5OA 1JKYA 1G12A 2E3XA 3I7GA 3SHIA 1DMTA 2MZHA 2N8RA 5D1TA 1UEAA 2YIGA 3G5CA 1GO7P 1GE7A 1PWWA 1BIWA 3RTTA 3HBVP 3K7LA 3HY7A 3UVCA 1HFCA 2X3BA 4L19A 4XM6A 1JH1A 2HU6A 1UTTA 4DD8A 4GWMA 4DV8A 4JQGA 1R1JA 2MZEA 1BQOA 1RM8A 2OXZA 4HX3A 1Y93A 3EHYA 4WZVA 1QICA 4JPAA 5L7FA 3P1VA 3LJGA 1B3DA 3KHIA 3U1RA 1A85A 2OXUA 1JIWP 4GR3A 3HB2P 4A7BA 2X7MA 2MLRA 1XFYA 3CKIA 2ERPA 1K7QA 1IACA 2KRJA 3F1AA 1GO8P 1JK3A 1ASTA 1GKCA 1ZS0A 2D1NA 1SLNA 1SLMA 2D1OA 1I73A 3LJTA 4L7AA 3LQ0A 1I76A 2TCLA 1OS9A 3DSLA 3EDIA 1UTZA 4FVLA 5I4OA 1KUGA 2W12A 1MMQA 3LEAA 2YB9A 1JAOA 2OZRA
chains in the Genus database with same CATH topology
2OY2A 1USNA 4PKSA 2AYKA 1CIZA 1CAQA 2I47A 3HYGA 1Y8JA 4WK7A 1ZXCA 1ZP5A 5LABA 1BQQM 1MMBA 2X3CA 2DW1A 1SRPA 1JAQA 2ERQA 4IUWA 3GBOA 3MA2A 3TVCA 1RMZA 3O2XA 4AYKA 5CZMA 4JA1A 5I2ZA 2DW2A 2W15A 3LIRA 3DL1A 5H8XA 3WV1A 3EDHA 2JT6A 2PJTA 1YP1A 1EB6A 4DF9A 3USNA 1ND1A 3I7IA 1IAEA 1XURA 4I03A 4AIGA 3WV3A 4PKVA 4EFSA 4AXQA 4PKTA 1BKCI 1CGLA 5D2BA 3AIGA 1FBLA 1R54A 3VTGA 2JIHA 4L63A 456CA 5BOYA 1D5JA 2CLTA 966CA 1I1IP 2W0DA 2DW0A 2Y6DA 2X3AA 2O3EA 3BA0A 1HV5A 1IADA 5B5PA 1BKCA 1QIAA 5I0LA 3F17A 4I35A 3KECA 1IAAA 1C3IA 2J83A 4ZR5A 1KUIA 2FV9A 1ZXVA 3TT4A 3Q2GA 3HY9A 3KEKA 2MZIA 1MNCA 3DPEA 4H30A 3LE9A 1GE5A 3DTKA 1FM1A 3EHXA 4GR0A 1BKCE 1A86A 1R1IA 1BZSA 4FU4A 5BPAA 1S4BP 1UMSA 3RTSA 2OVZA 2K2GA 3OHLA 2YUFA 3B92A 1R55A 3DNGA 1D8MA 1XUDA 1JIZA 4H82A 1B8YA 1AF0A 1Y0VA 3EDGA 2WOAA 1KAPP 2W14A 4PKWA 1QUAA 3KWVC 4GWNA 1AYKA 1O0TA 4QKZA 4JIJA 5D7WA 1OM6A 3K7NA 1XFUA 2USNA 1G05A 3EDZA 5D1SA 1QJJA 4H76A 2OI0A 3Q2HA 1CGEA 4GF1A 1QJIA 3HBUP 1JAPA 2OW2A 1OM8A 1KBCA 1ZVXA 3DWBA 1D7XA 3LJZA 2V4BA 3KEJA 2WO8A 4WKIA 1YQYA 2O36A 3ZVSA 4H3XA 4PKUA 3LKAA 1GKDA 1UMTA 2XS3A 1G4KA 2L0RA 3G42A 4AUOA 3B8ZA 2OW9A 3ZXHA 1OS2A 2AIGP 3AYKA 4L6TA 1YOUA 2POJA 4R3VA 1L6JA 1O0QA 1XFVA 3DTEA 5L79A 5CUHA 4DPEA 3N2VA 830CA 1R1HA 3HDBA 2RJPA 4PKRA 5D1UA 3AYUA 1SATA 1ROSA 4H1QA 4XBHA 1KUFA 1C8TA 4CTHA 1BUVM 4PKQA 5CXAA 4G9LA 2SRTA 1CGFA 1GE6A 4WKEA 4WF6A 4A3WA 2E2DA 1D8FA 3F18A 1HTDA 4H2EA 3HDAP 1EAKA 1XFZA 3L0VA 1JJ9A 3NX7A 2OXWA 1MMPA 1JANA 2OW1A 1XFWA 5I3MA 2W13A 1QIBA 2XS4A 1DTHA 5BOTA 2DDYA 4XM8A 3ZUKA 3P24A 3EWJA 4HMAA 1KUKA 1GXDA 1Q3AA 1PWQA 1OO9A 2EROA 4GUYA 1J7NA 1XFXA 3KMCA 3V96B 3LMCA 1BM6A 1HOVA 1SMPA 1CQRA 2J0TA 1K7GA 3B2ZA 4G0DA 3DPFA 4ILWD 2JNPA 1BSWA 3WV2A 1CXVA 2RJQA 1EUBA 3F16A 4FXQA 2Z2DA 3LIKA 3LILA 3LUMA 3L0TA 2OW0A 4H49A 1G49A 5D3CA 1SU3A 1K7IA 1BUDA 2JT5A 2Y6CA 1AKLA 1ZTQA 2WO9A 2FV5A 1IAGA 4XCTA 1ATLA 3VI1A 3TSKA 1HFSA 1IABA 1HY7A 4Q1LA 2OVXA 3E8RA 1H71P 1PWPA 2CKIA 1YCMA 1OM7A 2MLSA 4IN9A 2OY4A 1PWUA 3DTIA 1KUHA 4GQLA 1WNIA 5I12A 3LGPA 3KMEA 1CK7A 4XM7A 5JMYA 3O64A 1PWVA 3N2UA 4H84A 4IJOA 5I43A 3TS4A 1G9KA 2DDFA 3F15A 3LUNA 1XUCA 3LQBA 4JP4A 1FLSA 1MMRA 4ON1A 3LK8A 3F19A 3OHOA 4GR8A 1C7KA 2JSDA 2QPJA 3KRYA 1OMJA 2A8HA 1Z3JA 4J4MA 2K9CA 4FXYP 3ELMA 5B5OA 1JKYA 1G12A 2E3XA 3I7GA 3SHIA 1DMTA 2MZHA 2N8RA 5D1TA 1UEAA 2YIGA 3G5CA 1GO7P 1GE7A 1PWWA 1BIWA 3RTTA 3HBVP 3K7LA 3HY7A 3UVCA 1HFCA 2X3BA 4L19A 4XM6A 1JH1A 2HU6A 1UTTA 4DD8A 4GWMA 4DV8A 4JQGA 1R1JA 2MZEA 1BQOA 1RM8A 2OXZA 4HX3A 1Y93A 3EHYA 4WZVA 1QICA 4JPAA 5L7FA 3P1VA 3LJGA 1B3DA 3KHIA 3U1RA 1A85A 2OXUA 1JIWP 4GR3A 3HB2P 4A7BA 2X7MA 2MLRA 1XFYA 3CKIA 2ERPA 1K7QA 1IACA 2KRJA 3F1AA 1GO8P 1JK3A 1ASTA 1GKCA 1ZS0A 2D1NA 1SLNA 1SLMA 2D1OA 1I73A 3LJTA 4L7AA 3LQ0A 1I76A 2TCLA 1OS9A 3DSLA 3EDIA 1UTZA 4FVLA 5I4OA 1KUGA 2W12A 1MMQA 3LEAA 2YB9A 1JAOA 2OZRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OY2 A;  1USN A;  4PKS A;  2AYK A;  1CIZ A;  1CAQ A;  2I47 A;  3HYG A;  1Y8J A;  4WK7 A;  1ZXC A;  1ZP5 A;  5LAB A;  1BQQ M;  1MMB A;  2X3C A;  2DW1 A;  1SRP A;  1JAQ A;  2ERQ A;  4IUW A;  3GBO A;  3MA2 A;  3TVC A;  1RMZ A;  3O2X A;  4AYK A;  5CZM A;  4JA1 A;  5I2Z A;  2DW2 A;  2W15 A;  3LIR A;  3DL1 A;  5H8X A;  3WV1 A;  3EDH A;  2JT6 A;  2PJT A;  1YP1 A;  1EB6 A;  4DF9 A;  3USN A;  1ND1 A;  3I7I A;  1IAE A;  1XUR A;  4I03 A;  4AIG A;  3WV3 A;  4PKV A;  4EFS A;  4AXQ A;  4PKT A;  1BKC I;  1CGL A;  5D2B A;  3AIG A;  1FBL A;  1R54 A;  3VTG A;  2JIH A;  4L63 A;  456C A;  5BOY A;  1D5J A;  2CLT A;  966C A;  1I1I P;  2W0D A;  2DW0 A;  2Y6D A;  2X3A A;  2O3E A;  3BA0 A;  1HV5 A;  1IAD A;  5B5P A;  1BKC A;  1QIA A;  5I0L A;  3F17 A;  4I35 A;  3KEC A;  1IAA A;  1C3I A;  2J83 A;  4ZR5 A;  1KUI A;  2FV9 A;  1ZXV A;  3TT4 A;  3Q2G A;  3HY9 A;  3KEK A;  2MZI A;  1MNC A;  3DPE A;  4H30 A;  3LE9 A;  1GE5 A;  1FM1 A;  3EHX A;  4GR0 A;  1BKC E;  1A86 A;  1R1I A;  1BZS A;  4FU4 A;  5BPA A;  1S4B P;  1UMS A;  3RTS A;  2OVZ A;  2K2G A;  3OHL A;  3B92 A;  1R55 A;  3DNG A;  1D8M A;  1XUD A;  1JIZ A;  4H82 A;  1B8Y A;  1AF0 A;  1Y0V A;  3EDG A;  2WOA A;  1KAP P;  2W14 A;  4PKW A;  1QUA A;  3KWV C;  4GWN A;  1AYK A;  1O0T A;  4QKZ A;  4JIJ A;  5D7W A;  1OM6 A;  3K7N A;  1XFU A;  2USN A;  1G05 A;  3EDZ A;  5D1S A;  1QJJ A;  4H76 A;  2OI0 A;  3Q2H A;  1CGE A;  4GF1 A;  1QJI A;  3HBU P;  1JAP A;  2OW2 A;  1OM8 A;  1KBC A;  1ZVX A;  3DWB A;  1D7X A;  3LJZ A;  2V4B A;  3KEJ A;  2WO8 A;  4WKI A;  1YQY A;  2O36 A;  3ZVS A;  4H3X A;  4PKU A;  3LKA A;  1GKD A;  1UMT A;  2XS3 A;  1G4K A;  2L0R A;  3G42 A;  4AUO A;  3B8Z A;  2OW9 A;  3ZXH A;  1OS2 A;  2AIG P;  3AYK A;  4L6T A;  1YOU A;  2POJ A;  4R3V A;  1L6J A;  1O0Q A;  1XFV A;  5L79 A;  5CUH A;  4DPE A;  3N2V A;  830C A;  1R1H A;  3HDB A;  2RJP A;  4PKR A;  5D1U A;  3AYU A;  1SAT A;  1ROS A;  4H1Q A;  4XBH A;  1KUF A;  1C8T A;  4CTH A;  1BUV M;  4PKQ A;  5CXA A;  4G9L A;  2SRT A;  1CGF A;  1GE6 A;  4WKE A;  4WF6 A;  4A3W A;  2E2D A;  1D8F A;  3F18 A;  1HTD A;  4H2E A;  3HDA P;  1EAK A;  1XFZ A;  3L0V A;  1JJ9 A;  3NX7 A;  2OXW A;  1MMP A;  1JAN A;  2OW1 A;  1XFW A;  5I3M A;  2W13 A;  1QIB A;  2XS4 A;  1DTH A;  5BOT A;  2DDY A;  4XM8 A;  3ZUK A;  3P24 A;  3EWJ A;  4HMA A;  1KUK A;  1GXD A;  1Q3A A;  1PWQ A;  1OO9 A;  2ERO A;  4GUY A;  1J7N A;  1XFX A;  3KMC A;  3V96 B;  3LMC A;  1BM6 A;  1HOV A;  1SMP A;  1CQR A;  2J0T A;  1K7G A;  3B2Z A;  4G0D A;  3DPF A;  4ILW D;  2JNP A;  1BSW A;  3WV2 A;  1CXV A;  2RJQ A;  1EUB A;  3F16 A;  4FXQ A;  2Z2D A;  3LIK A;  3LIL A;  3LUM A;  3L0T A;  2OW0 A;  4H49 A;  1G49 A;  5D3C A;  1SU3 A;  1K7I A;  1BUD A;  2JT5 A;  2Y6C A;  1AKL A;  1ZTQ A;  2WO9 A;  2FV5 A;  1IAG A;  4XCT A;  1ATL A;  3VI1 A;  3TSK A;  1HFS A;  1IAB A;  1HY7 A;  4Q1L A;  2OVX A;  3E8R A;  1H71 P;  1PWP A;  2CKI A;  1YCM A;  1OM7 A;  2MLS A;  4IN9 A;  2OY4 A;  1PWU A;  1KUH A;  4GQL A;  1WNI A;  5I12 A;  3LGP A;  3KME A;  1CK7 A;  4XM7 A;  5JMY A;  3O64 A;  1PWV A;  3N2U A;  4H84 A;  4IJO A;  5I43 A;  3TS4 A;  1G9K A;  2DDF A;  3F15 A;  3LUN A;  1XUC A;  3LQB A;  4JP4 A;  1FLS A;  1MMR A;  4ON1 A;  3LK8 A;  3F19 A;  3OHO A;  4GR8 A;  1C7K A;  2JSD A;  2QPJ A;  3KRY A;  1OMJ A;  2A8H A;  1Z3J A;  4J4M A;  2K9C A;  4FXY P;  3ELM A;  5B5O A;  1JKY A;  1G12 A;  2E3X A;  3I7G A;  3SHI A;  1DMT A;  2MZH A;  2N8R A;  5D1T A;  1UEA A;  2YIG A;  3G5C A;  1GO7 P;  1GE7 A;  1PWW A;  1BIW A;  3RTT A;  3HBV P;  3K7L A;  3HY7 A;  3UVC A;  1HFC A;  2X3B A;  4L19 A;  4XM6 A;  1JH1 A;  2HU6 A;  1UTT A;  4DD8 A;  4GWM A;  4DV8 A;  4JQG A;  1R1J A;  2MZE A;  1BQO A;  1RM8 A;  2OXZ A;  4HX3 A;  1Y93 A;  3EHY A;  4WZV A;  1QIC A;  4JPA A;  5L7F A;  3P1V A;  3LJG A;  1B3D A;  3KHI A;  3U1R A;  1A85 A;  2OXU A;  1JIW P;  4GR3 A;  3HB2 P;  4A7B A;  2X7M A;  2MLR A;  1XFY A;  3CKI A;  2ERP A;  1K7Q A;  1IAC A;  2KRJ A;  3F1A A;  1GO8 P;  1JK3 A;  1AST A;  1GKC A;  1ZS0 A;  2D1N A;  1SLN A;  1SLM A;  2D1O A;  1I73 A;  3LJT A;  3LQ0 A;  1I76 A;  2TCL A;  1OS9 A;  3DSL A;  3EDI A;  1UTZ A;  4FVL A;  5I4O A;  1KUG A;  2W12 A;  1MMQ A;  3LEA A;  2YB9 A;  1JAO A;  2OZR A; 
#chains in the Genus database with same CATH topology
 2OY2 A;  1USN A;  4PKS A;  2AYK A;  1CIZ A;  1CAQ A;  2I47 A;  3HYG A;  1Y8J A;  4WK7 A;  1ZXC A;  1ZP5 A;  5LAB A;  1BQQ M;  1MMB A;  2X3C A;  2DW1 A;  1SRP A;  1JAQ A;  2ERQ A;  4IUW A;  3GBO A;  3MA2 A;  3TVC A;  1RMZ A;  3O2X A;  4AYK A;  5CZM A;  4JA1 A;  5I2Z A;  2DW2 A;  2W15 A;  3LIR A;  3DL1 A;  5H8X A;  3WV1 A;  3EDH A;  2JT6 A;  2PJT A;  1YP1 A;  1EB6 A;  4DF9 A;  3USN A;  1ND1 A;  3I7I A;  1IAE A;  1XUR A;  4I03 A;  4AIG A;  3WV3 A;  4PKV A;  4EFS A;  4AXQ A;  4PKT A;  1BKC I;  1CGL A;  5D2B A;  3AIG A;  1FBL A;  1R54 A;  3VTG A;  2JIH A;  4L63 A;  456C A;  5BOY A;  1D5J A;  1XM5 A;  2CLT A;  966C A;  1I1I P;  2W0D A;  2DW0 A;  2Y6D A;  2X3A A;  2O3E A;  3BA0 A;  1HV5 A;  1IAD A;  5B5P A;  1BKC A;  1QIA A;  5I0L A;  3F17 A;  4I35 A;  3KEC A;  1IAA A;  1C3I A;  2J83 A;  4ZR5 A;  1KUI A;  2FV9 A;  1ZXV A;  3TT4 A;  3Q2G A;  3HY9 A;  3KEK A;  2MZI A;  1MNC A;  3DPE A;  4H30 A;  3LE9 A;  1GE5 A;  3DTK A;  1FM1 A;  3EHX A;  4GR0 A;  1BKC E;  1A86 A;  1R1I A;  1BZS A;  4FU4 A;  5BPA A;  1S4B P;  1UMS A;  3RTS A;  2OVZ A;  2K2G A;  3OHL A;  2YUF A;  3B92 A;  1R55 A;  3DNG A;  1D8M A;  1XUD A;  1JIZ A;  4H82 A;  1B8Y A;  1AF0 A;  1Y0V A;  3EDG A;  2WOA A;  1KAP P;  2W14 A;  4PKW A;  1QUA A;  3KWV C;  4GWN A;  1AYK A;  1O0T A;  4QKZ A;  4JIJ A;  5D7W A;  1OM6 A;  3K7N A;  1XFU A;  2USN A;  1G05 A;  3EDZ A;  5D1S A;  1QJJ A;  4H76 A;  2OI0 A;  3Q2H A;  1CGE A;  4GF1 A;  1QJI A;  3HBU P;  1JAP A;  2OW2 A;  1OM8 A;  1KBC A;  1ZVX A;  3DWB A;  1D7X A;  3LJZ A;  2V4B A;  3KEJ A;  2WO8 A;  4WKI A;  1YQY A;  2O36 A;  3ZVS A;  4H3X A;  4PKU A;  3LKA A;  1GKD A;  1UMT A;  2XS3 A;  1G4K A;  2L0R A;  3G42 A;  4AUO A;  3B8Z A;  2OW9 A;  3ZXH A;  1OS2 A;  2AIG P;  3AYK A;  4L6T A;  1YOU A;  2POJ A;  4R3V A;  1L6J A;  1O0Q A;  1XFV A;  3DTE A;  5L79 A;  5CUH A;  4DPE A;  3N2V A;  830C A;  1R1H A;  3HDB A;  2RJP A;  4PKR A;  5D1U A;  3AYU A;  1SAT A;  1ROS A;  4H1Q A;  4XBH A;  1KUF A;  1C8T A;  4CTH A;  1BUV M;  4PKQ A;  5CXA A;  4G9L A;  2SRT A;  1CGF A;  1GE6 A;  4WKE A;  4WF6 A;  4A3W A;  2E2D A;  1D8F A;  3F18 A;  1HTD A;  4H2E A;  3HDA P;  1EAK A;  1XFZ A;  3L0V A;  1JJ9 A;  3NX7 A;  2OXW A;  1MMP A;  1JAN A;  2OW1 A;  1XFW A;  5I3M A;  2W13 A;  1QIB A;  2XS4 A;  1DTH A;  5BOT A;  2DDY A;  4XM8 A;  3ZUK A;  3P24 A;  3EWJ A;  4HMA A;  1KUK A;  1GXD A;  1Q3A A;  1PWQ A;  1OO9 A;  2ERO A;  4GUY A;  1J7N A;  1XFX A;  3KMC A;  3V96 B;  3LMC A;  1BM6 A;  1HOV A;  1SMP A;  1CQR A;  2J0T A;  1K7G A;  3B2Z A;  4G0D A;  3DPF A;  4ILW D;  2JNP A;  1BSW A;  3WV2 A;  1CXV A;  2RJQ A;  1EUB A;  3F16 A;  4FXQ A;  2Z2D A;  3LIK A;  3LIL A;  3LUM A;  3L0T A;  2OW0 A;  4H49 A;  1G49 A;  5D3C A;  1SU3 A;  1K7I A;  1BUD A;  2JT5 A;  2Y6C A;  1AKL A;  1ZTQ A;  2WO9 A;  2FV5 A;  1IAG A;  4XCT A;  1ATL A;  3VI1 A;  3TSK A;  1OZ9 A;  1HFS A;  1IAB A;  1HY7 A;  4Q1L A;  2OVX A;  3E8R A;  1H71 P;  1PWP A;  2CKI A;  1YCM A;  1OM7 A;  2MLS A;  4IN9 A;  2OY4 A;  1PWU A;  3DTI A;  1KUH A;  4GQL A;  1WNI A;  5I12 A;  3LGP A;  1XAX A;  3KME A;  1CK7 A;  4XM7 A;  5JMY A;  3O64 A;  1PWV A;  3N2U A;  4H84 A;  4IJO A;  5I43 A;  3TS4 A;  1G9K A;  2DDF A;  3F15 A;  3LUN A;  1TVI A;  1XUC A;  3LQB A;  4JP4 A;  1FLS A;  1MMR A;  4ON1 A;  3LK8 A;  3F19 A;  3OHO A;  4GR8 A;  1C7K A;  2JSD A;  2QPJ A;  3KRY A;  1OMJ A;  2A8H A;  1Z3J A;  4J4M A;  2K9C A;  4FXY P;  3ELM A;  5B5O A;  1JKY A;  1G12 A;  2E3X A;  3I7G A;  3SHI A;  1DMT A;  2MZH A;  2N8R A;  5D1T A;  1UEA A;  2YIG A;  3G5C A;  1GO7 P;  1GE7 A;  1PWW A;  1BIW A;  3RTT A;  3HBV P;  3K7L A;  3HY7 A;  3UVC A;  1HFC A;  2X3B A;  4L19 A;  4XM6 A;  1JH1 A;  2HU6 A;  1UTT A;  4DD8 A;  4GWM A;  4DV8 A;  4JQG A;  1R1J A;  2MZE A;  1BQO A;  1RM8 A;  2OXZ A;  4HX3 A;  1Y93 A;  3EHY A;  4WZV A;  1QIC A;  4JPA A;  5L7F A;  3P1V A;  3LJG A;  1B3D A;  3KHI A;  3U1R A;  1A85 A;  2OXU A;  1JIW P;  4GR3 A;  3HB2 P;  4A7B A;  2X7M A;  2MLR A;  1XFY A;  3CKI A;  2ERP A;  1K7Q A;  1IAC A;  2KRJ A;  3F1A A;  1GO8 P;  1JK3 A;  1AST A;  1GKC A;  1ZS0 A;  2D1N A;  1SLN A;  1SLM A;  2D1O A;  1I73 A;  3LJT A;  4L7A A;  3LQ0 A;  1I76 A;  2TCL A;  1OS9 A;  3DSL A;  3EDI A;  1UTZ A;  4FVL A;  5I4O A;  1KUG A;  2W12 A;  1MMQ A;  3LEA A;  2YB9 A;  1JAO A;  2OZR A; 
#chains in the Genus database with same CATH homology
 2OY2 A;  1USN A;  4PKS A;  2AYK A;  1CIZ A;  1CAQ A;  2I47 A;  3HYG A;  1Y8J A;  4WK7 A;  1ZXC A;  1ZP5 A;  5LAB A;  1BQQ M;  1MMB A;  2X3C A;  2DW1 A;  1SRP A;  1JAQ A;  2ERQ A;  4IUW A;  3GBO A;  3MA2 A;  3TVC A;  1RMZ A;  3O2X A;  4AYK A;  5CZM A;  4JA1 A;  5I2Z A;  2DW2 A;  2W15 A;  3LIR A;  3DL1 A;  5H8X A;  3WV1 A;  3EDH A;  2JT6 A;  2PJT A;  1YP1 A;  1EB6 A;  4DF9 A;  3USN A;  1ND1 A;  3I7I A;  1IAE A;  1XUR A;  4I03 A;  4AIG A;  3WV3 A;  4PKV A;  4EFS A;  4AXQ A;  4PKT A;  1BKC I;  1CGL A;  5D2B A;  3AIG A;  1FBL A;  1R54 A;  3VTG A;  2JIH A;  4L63 A;  456C A;  5BOY A;  1D5J A;  2CLT A;  966C A;  1I1I P;  2W0D A;  2DW0 A;  2Y6D A;  2X3A A;  2O3E A;  3BA0 A;  1HV5 A;  1IAD A;  5B5P A;  1BKC A;  1QIA A;  5I0L A;  3F17 A;  4I35 A;  3KEC A;  1IAA A;  1C3I A;  2J83 A;  4ZR5 A;  1KUI A;  2FV9 A;  1ZXV A;  3TT4 A;  3Q2G A;  3HY9 A;  3KEK A;  2MZI A;  1MNC A;  3DPE A;  4H30 A;  3LE9 A;  1GE5 A;  3DTK A;  1FM1 A;  3EHX A;  4GR0 A;  1BKC E;  1A86 A;  1R1I A;  1BZS A;  4FU4 A;  5BPA A;  1S4B P;  1UMS A;  3RTS A;  2OVZ A;  2K2G A;  3OHL A;  2YUF A;  3B92 A;  1R55 A;  3DNG A;  1D8M A;  1XUD A;  1JIZ A;  4H82 A;  1B8Y A;  1AF0 A;  1Y0V A;  3EDG A;  2WOA A;  1KAP P;  2W14 A;  4PKW A;  1QUA A;  3KWV C;  4GWN A;  1AYK A;  1O0T A;  4QKZ A;  4JIJ A;  5D7W A;  1OM6 A;  3K7N A;  1XFU A;  2USN A;  1G05 A;  3EDZ A;  5D1S A;  1QJJ A;  4H76 A;  2OI0 A;  3Q2H A;  1CGE A;  4GF1 A;  1QJI A;  3HBU P;  1JAP A;  2OW2 A;  1OM8 A;  1KBC A;  1ZVX A;  3DWB A;  1D7X A;  3LJZ A;  2V4B A;  3KEJ A;  2WO8 A;  4WKI A;  1YQY A;  2O36 A;  3ZVS A;  4H3X A;  4PKU A;  3LKA A;  1GKD A;  1UMT A;  2XS3 A;  1G4K A;  2L0R A;  3G42 A;  4AUO A;  3B8Z A;  2OW9 A;  3ZXH A;  1OS2 A;  2AIG P;  3AYK A;  4L6T A;  1YOU A;  2POJ A;  4R3V A;  1L6J A;  1O0Q A;  1XFV A;  3DTE A;  5L79 A;  5CUH A;  4DPE A;  3N2V A;  830C A;  1R1H A;  3HDB A;  2RJP A;  4PKR A;  5D1U A;  3AYU A;  1SAT A;  1ROS A;  4H1Q A;  4XBH A;  1KUF A;  1C8T A;  4CTH A;  1BUV M;  4PKQ A;  5CXA A;  4G9L A;  2SRT A;  1CGF A;  1GE6 A;  4WKE A;  4WF6 A;  4A3W A;  2E2D A;  1D8F A;  3F18 A;  1HTD A;  4H2E A;  3HDA P;  1EAK A;  1XFZ A;  3L0V A;  1JJ9 A;  3NX7 A;  2OXW A;  1MMP A;  1JAN A;  2OW1 A;  1XFW A;  5I3M A;  2W13 A;  1QIB A;  2XS4 A;  1DTH A;  5BOT A;  2DDY A;  4XM8 A;  3ZUK A;  3P24 A;  3EWJ A;  4HMA A;  1KUK A;  1GXD A;  1Q3A A;  1PWQ A;  1OO9 A;  2ERO A;  4GUY A;  1J7N A;  1XFX A;  3KMC A;  3V96 B;  3LMC A;  1BM6 A;  1HOV A;  1SMP A;  1CQR A;  2J0T A;  1K7G A;  3B2Z A;  4G0D A;  3DPF A;  4ILW D;  2JNP A;  1BSW A;  3WV2 A;  1CXV A;  2RJQ A;  1EUB A;  3F16 A;  4FXQ A;  2Z2D A;  3LIK A;  3LIL A;  3LUM A;  3L0T A;  2OW0 A;  4H49 A;  1G49 A;  5D3C A;  1SU3 A;  1K7I A;  1BUD A;  2JT5 A;  2Y6C A;  1AKL A;  1ZTQ A;  2WO9 A;  2FV5 A;  1IAG A;  4XCT A;  1ATL A;  3VI1 A;  3TSK A;  1HFS A;  1IAB A;  1HY7 A;  4Q1L A;  2OVX A;  3E8R A;  1H71 P;  1PWP A;  2CKI A;  1YCM A;  1OM7 A;  2MLS A;  4IN9 A;  2OY4 A;  1PWU A;  3DTI A;  1KUH A;  4GQL A;  1WNI A;  5I12 A;  3LGP A;  3KME A;  1CK7 A;  4XM7 A;  5JMY A;  3O64 A;  1PWV A;  3N2U A;  4H84 A;  4IJO A;  5I43 A;  3TS4 A;  1G9K A;  2DDF A;  3F15 A;  3LUN A;  1XUC A;  3LQB A;  4JP4 A;  1FLS A;  1MMR A;  4ON1 A;  3LK8 A;  3F19 A;  3OHO A;  4GR8 A;  1C7K A;  2JSD A;  2QPJ A;  3KRY A;  1OMJ A;  2A8H A;  1Z3J A;  4J4M A;  2K9C A;  4FXY P;  3ELM A;  5B5O A;  1JKY A;  1G12 A;  2E3X A;  3I7G A;  3SHI A;  1DMT A;  2MZH A;  2N8R A;  5D1T A;  1UEA A;  2YIG A;  3G5C A;  1GO7 P;  1GE7 A;  1PWW A;  1BIW A;  3RTT A;  3HBV P;  3K7L A;  3HY7 A;  3UVC A;  1HFC A;  2X3B A;  4L19 A;  4XM6 A;  1JH1 A;  2HU6 A;  1UTT A;  4DD8 A;  4GWM A;  4DV8 A;  4JQG A;  1R1J A;  2MZE A;  1BQO A;  1RM8 A;  2OXZ A;  4HX3 A;  1Y93 A;  3EHY A;  4WZV A;  1QIC A;  4JPA A;  5L7F A;  3P1V A;  3LJG A;  1B3D A;  3KHI A;  3U1R A;  1A85 A;  2OXU A;  1JIW P;  4GR3 A;  3HB2 P;  4A7B A;  2X7M A;  2MLR A;  1XFY A;  3CKI A;  2ERP A;  1K7Q A;  1IAC A;  2KRJ A;  3F1A A;  1GO8 P;  1JK3 A;  1AST A;  1GKC A;  1ZS0 A;  2D1N A;  1SLN A;  1SLM A;  2D1O A;  1I73 A;  3LJT A;  4L7A A;  3LQ0 A;  1I76 A;  2TCL A;  1OS9 A;  3DSL A;  3EDI A;  1UTZ A;  4FVL A;  5I4O A;  1KUG A;  2W12 A;  1MMQ A;  3LEA A;  2YB9 A;  1JAO A;  2OZR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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