3LE9A

Crystal structure of the catalytic domain of tace with indazolinone-phenyl-hydantoin inhibitor
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
257
structure length
251
Chain Sequence
PDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Disintegrin and metalloproteinase domain-containing protein
publication title Biaryl substituted hydantoin compounds as TACE inhibitors.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 81
structure length 251
sequence length 257
chains with identical sequence B
ec nomenclature ec 3.4.24.86: ADAM 17 endopeptidase.
pdb deposition date 2010-01-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13688 Reprolysin_5 Metallo-peptidase family M12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3le9A00
3ZVSA 3VTGA 3NX7A 1Q3AA 4JP4A 1IACA 1XFZA 3LKAA 4XCTA 5LABA 4AUOA 1UMSA 3AYUA 1O0QA 1UTTA 3K7LA 4GR8A 1MMBA 1O0TA 1GO7P 2L0RA 2D1OA 1BIWA 5D1SA 5L7FA 3B8ZA 3O2XA 1HV5A 2CKIA 4DD8A 3LQ0A 3F1AA 4ZR5A 1JKYA 4GF1A 4IN9A 5I12A 3F18A 3HYGA 1AF0A 2DDFA 4PKVA 3EDHA 1Y0VA 1K7GA 1D7XA 1SU3A 1QIBA 1IABA 3WV1A 3LIRA 5CUHA 3DSLA 1HOVA 5I3MA 5I2ZA 2SRTA 4PKWA 3LE9A 4J4MA 4H76A 3N2UA 3LUMA 4XM8A 5L79A 1FM1A 1G49A 2J83A 2DW1A 3GBOA 1IAEA 4WF6A 5D3CA 5BPAA 2PJTA 4AYKA 3HB2P 2OW1A 3LIKA 2OW9A 4JA1A 1I76A 1KUHA 1R1HA 2Y6CA 1CGFA 4JQGA 3HBVP 2DW2A 3USNA 3LJTA 3EHYA 4H49A 1JIZA 1JJ9A 3F16A 1FBLA 4JPAA 3DPEA 5I0LA 1I1IP 2OW0A 1Y8JA 1J7NA 3KEJA 2Z2DA 3SHIA 3DWBA 3HDBA 1JH1A 1CGEA 966CA 2ERPA 1OS2A 3ZUKA 3F15A 1R55A 2RJPA 3CKIA 4PKUA 4DV8A 1DTHA 4I03A 4AIGA 3KWVC 5B5PA 5BOTA 1GXDA 1GKCA 2MLRA 4HMAA 1HTDA 1ZXCA 2AYKA 4H82A 1YOUA 1YCMA 1C8TA 1XURA 3LJZA 4HX3A 3HDAP 1YP1A 2FV9A 2EROA 4GWMA 5I43A 1KUFA 1BKCE 1SLMA 1B8YA 2AIGP 2JNPA 1R1IA 2W13A 1G9KA 1QJJA 1DMTA 5D2BA 4ON1A 5B5OA 2OVZA 4G9LA 3KRYA 4JIJA 2WO8A 2MLSA 2W0DA 2OXWA 1QIAA 2ERQA 5D1UA 2TCLA 2OZRA 1H71P 456CA 4A3WA 1CXVA 1BKCI 4H3XA 4ILWD 1OO9A 1JK3A 3ELMA 3TS4A 1HY7A 1SMPA 2WOAA 5I4OA 2X7MA 4WK7A 1ZVXA 2X3CA 3L0VA 3BA0A 1PWVA 2OY2A 4GR3A 4H1QA 2OY4A 1R54A 4GWNA 4GR0A 2W14A 1XUDA 1ND1A 2WO9A 2XS3A 1XFUA 3RTTA 4IUWA 1BM6A 3HBUP 3P1VA 1JAQA 3AYKA 1QUAA 4XBHA 1S4BP 1YQYA 2JT5A 2OW2A 1I73A 1OM7A 1K7QA 3WV2A 1GE7A 4EFSA 1KAPP 2Y6DA 3TVCA 1ZXVA 3N2VA 1WNIA 2V4BA 1XUCA 1BSWA 1KUKA 3LUNA 4L19A 1GO8P 1B3DA 1L6JA 4FVLA 5CXAA 1ZS0A 1G4KA 2D1NA 3RTSA 1MNCA 3LJGA 1HFSA 1BKCA 1SRPA 1BUVM 3V96B 2W15A 4WZVA 1USNA 3EDIA 2J0TA 4L63A 1Z3JA 2RJQA 1EUBA 1CGLA 3B2ZA 1IAAA 1XFYA 4L6TA 2OXUA 1ASTA 3DL1A 3K7NA 1JANA 1GE5A 4CTHA 3I7IA 2MZIA 4H2EA 1A85A 1PWQA 3E8RA 1KUIA 4PKQA 5BOYA 1QJIA 1G05A 3Q2HA 3KHIA 3TSKA 1BQQM 4PKTA 1OMJA 4H30A 3F17A 1SLNA 3MA2A 1PWWA 2N8RA 1PWPA 2USNA 4A7BA 4XM7A 2HU6A 3VI1A 830CA 4IJOA 1IAGA 1OM6A 3TT4A 5H8XA 1AYKA 2XS4A 1G12A 3Q2GA 3WV3A 4FXYP 1CAQA 2K2GA 5D7WA 1KUGA 1A86A 3KMCA 3HY7A 3KMEA 4PKSA 3LQBA 1Y93A 3EDGA 4WKIA 3AIGA 3UVCA 1CK7A 3LK8A 3O64A 4FXQA 1FLSA 3LEAA 4FU4A 5CZMA 2W12A 1QICA 1JIWP 4DPEA 1ZP5A 2CLTA 2A8HA 4GQLA 1RMZA 1HFCA 2YIGA 1EB6A 1UEAA 3OHOA 3U1RA 4AXQA 1SATA 3G5CA 3B92A 1CIZA 2YB9A 1UTZA 2QPJA 3G42A 5JMYA 2K9CA 1RM8A 4DF9A 1EAKA 1D5JA 4XM6A 3LILA 1MMRA 3KEKA 1IADA 1JAOA 4WKEA 4R3VA 1K7IA 2OI0A 4PKRA 1OS9A 2JSDA 1D8MA 2FV5A 3DNGA 3ZXHA 5D1TA 2JT6A 4Q1LA 1ZTQA 1UMTA 1D8FA 3F19A 1C3IA 2E2DA 2I47A 1MMPA 4QKZA 1OM8A 1XFXA 3DPFA 1AKLA 2DDYA 1JAPA 3LMCA 4I35A 1BQOA 3EDZA 3EHXA 2POJA 3HY9A 2O3EA 1ATLA 1ROSA 2DW0A 1BZSA 1R1JA 1C7KA 3KECA 3EWJA 3LGPA 1BUDA 1CQRA 1MMQA 3L0TA 2KRJA 2E3XA 1XFWA 2X3BA 3P24A 4G0DA 2OVXA 4GUYA 1PWUA 1XFVA 4H84A 2O36A 3I7GA 2MZEA 2JIHA 1KBCA 2OXZA 2MZHA 2X3AA 1GKDA 1GE6A 3OHLA
chains in the Genus database with same CATH superfamily
3ZVSA 3VTGA 3NX7A 1Q3AA 4JP4A 1IACA 1XFZA 3LKAA 4XCTA 5LABA 4AUOA 1UMSA 3AYUA 1O0QA 1UTTA 3K7LA 4GR8A 1MMBA 1O0TA 1GO7P 2L0RA 2D1OA 1BIWA 5D1SA 5L7FA 3B8ZA 3O2XA 1HV5A 2CKIA 4DD8A 3LQ0A 3F1AA 4ZR5A 1JKYA 4GF1A 4IN9A 5I12A 3F18A 3HYGA 1AF0A 2DDFA 4PKVA 3EDHA 1Y0VA 1K7GA 1D7XA 1SU3A 1QIBA 1IABA 3WV1A 3LIRA 5CUHA 3DSLA 1HOVA 5I3MA 5I2ZA 2SRTA 4PKWA 3LE9A 4J4MA 4H76A 3N2UA 3LUMA 4XM8A 5L79A 1FM1A 1G49A 2J83A 2DW1A 3GBOA 1IAEA 4WF6A 2YUFA 5D3CA 5BPAA 2PJTA 4AYKA 3HB2P 2OW1A 3LIKA 2OW9A 4JA1A 1I76A 1KUHA 1R1HA 2Y6CA 1CGFA 4JQGA 3HBVP 2DW2A 3USNA 3LJTA 3EHYA 4H49A 1JIZA 1JJ9A 3F16A 1FBLA 4JPAA 3DPEA 5I0LA 1I1IP 2OW0A 1Y8JA 1J7NA 3KEJA 2Z2DA 3SHIA 3DWBA 3HDBA 1JH1A 1CGEA 966CA 2ERPA 1OS2A 3ZUKA 3F15A 1R55A 2RJPA 3CKIA 4PKUA 4DV8A 3DTEA 1DTHA 4I03A 4AIGA 3KWVC 5B5PA 5BOTA 1GXDA 1GKCA 2MLRA 4HMAA 1HTDA 1ZXCA 2AYKA 4H82A 1YOUA 1YCMA 1C8TA 1XURA 3LJZA 4HX3A 3HDAP 1YP1A 2FV9A 2EROA 4GWMA 5I43A 1KUFA 1BKCE 1SLMA 1B8YA 2AIGP 2JNPA 1R1IA 2W13A 1G9KA 1QJJA 1DMTA 5D2BA 4ON1A 5B5OA 2OVZA 4G9LA 3KRYA 4JIJA 2WO8A 2MLSA 2W0DA 2OXWA 1QIAA 2ERQA 5D1UA 2TCLA 2OZRA 1H71P 456CA 4A3WA 1CXVA 1BKCI 4H3XA 4ILWD 4L7AA 1OZ9A 1OO9A 1JK3A 3ELMA 3TS4A 1HY7A 1SMPA 2WOAA 5I4OA 2X7MA 4WK7A 1ZVXA 2X3CA 3L0VA 3BA0A 1PWVA 2OY2A 4GR3A 4H1QA 2OY4A 1R54A 4GWNA 4GR0A 2W14A 1XUDA 1ND1A 2WO9A 2XS3A 1XFUA 3RTTA 4IUWA 1BM6A 3HBUP 3P1VA 1JAQA 3AYKA 1QUAA 4XBHA 1S4BP 1YQYA 2JT5A 2OW2A 1I73A 1OM7A 1K7QA 3WV2A 1GE7A 4EFSA 1KAPP 2Y6DA 3TVCA 1ZXVA 3N2VA 1WNIA 2V4BA 1XUCA 1BSWA 1KUKA 3LUNA 4L19A 1GO8P 3DTIA 1B3DA 1L6JA 4FVLA 5CXAA 1ZS0A 1G4KA 2D1NA 3RTSA 1MNCA 3LJGA 1HFSA 1BKCA 1SRPA 1BUVM 3V96B 2W15A 4WZVA 1USNA 3EDIA 2J0TA 4L63A 1Z3JA 2RJQA 1EUBA 1CGLA 3B2ZA 1XM5A 1IAAA 1XFYA 4L6TA 2OXUA 1ASTA 3DL1A 3K7NA 1JANA 1GE5A 4CTHA 3I7IA 2MZIA 4H2EA 1A85A 1PWQA 3E8RA 1KUIA 4PKQA 5BOYA 1QJIA 1G05A 3Q2HA 3KHIA 3TSKA 1BQQM 4PKTA 1OMJA 4H30A 3F17A 1SLNA 3MA2A 1PWWA 2N8RA 1PWPA 2USNA 4A7BA 4XM7A 2HU6A 3VI1A 830CA 4IJOA 1IAGA 1OM6A 3TT4A 5H8XA 1AYKA 2XS4A 1G12A 3Q2GA 3WV3A 4FXYP 1CAQA 2K2GA 5D7WA 1KUGA 1A86A 3KMCA 3HY7A 3KMEA 4PKSA 3LQBA 1Y93A 3EDGA 4WKIA 3AIGA 3UVCA 1CK7A 3LK8A 3O64A 4FXQA 1FLSA 3LEAA 4FU4A 5CZMA 2W12A 1QICA 1JIWP 4DPEA 1ZP5A 2CLTA 2A8HA 4GQLA 1RMZA 1HFCA 2YIGA 1EB6A 1UEAA 3OHOA 3U1RA 4AXQA 1XAXA 1SATA 3G5CA 3B92A 1CIZA 2YB9A 1UTZA 2QPJA 3G42A 5JMYA 2K9CA 1RM8A 4DF9A 1EAKA 1D5JA 4XM6A 3LILA 1MMRA 3KEKA 1IADA 1JAOA 4WKEA 4R3VA 1K7IA 2OI0A 4PKRA 1OS9A 2JSDA 1D8MA 2FV5A 3DNGA 3ZXHA 5D1TA 2JT6A 4Q1LA 1ZTQA 1UMTA 1D8FA 3F19A 1C3IA 2E2DA 2I47A 1MMPA 4QKZA 1OM8A 1XFXA 3DPFA 1AKLA 2DDYA 1JAPA 3LMCA 4I35A 1BQOA 3EDZA 3EHXA 2POJA 3HY9A 2O3EA 1ATLA 1ROSA 2DW0A 3DTKA 1BZSA 1R1JA 1C7KA 3KECA 3EWJA 3LGPA 1BUDA 1CQRA 1MMQA 3L0TA 2KRJA 2E3XA 1XFWA 2X3BA 3P24A 4G0DA 2OVXA 4GUYA 1PWUA 1XFVA 4H84A 2O36A 3I7GA 2MZEA 2JIHA 1KBCA 1TVIA 2OXZA 2MZHA 2X3AA 1GKDA 1GE6A 3OHLA
chains in the Genus database with same CATH topology
3ZVSA 3VTGA 3NX7A 1Q3AA 4JP4A 1IACA 1XFZA 3LKAA 4XCTA 5LABA 4AUOA 1UMSA 3AYUA 1O0QA 1UTTA 3K7LA 4GR8A 1MMBA 1O0TA 1GO7P 2L0RA 2D1OA 1BIWA 5D1SA 5L7FA 3B8ZA 3O2XA 1HV5A 2CKIA 4DD8A 3LQ0A 3F1AA 4ZR5A 1JKYA 4GF1A 4IN9A 5I12A 3F18A 3HYGA 1AF0A 2DDFA 4PKVA 3EDHA 1Y0VA 1K7GA 1D7XA 1SU3A 1QIBA 1IABA 3WV1A 3LIRA 5CUHA 3DSLA 1HOVA 5I3MA 5I2ZA 2SRTA 4PKWA 3LE9A 4J4MA 4H76A 3N2UA 3LUMA 4XM8A 5L79A 1FM1A 1G49A 2J83A 2DW1A 3GBOA 1IAEA 4WF6A 2YUFA 5D3CA 5BPAA 2PJTA 4AYKA 3HB2P 2OW1A 3LIKA 2OW9A 4JA1A 1I76A 1KUHA 1R1HA 2Y6CA 1CGFA 4JQGA 3HBVP 2DW2A 3USNA 3LJTA 3EHYA 4H49A 1JIZA 1JJ9A 3F16A 1FBLA 4JPAA 3DPEA 5I0LA 1I1IP 2OW0A 1Y8JA 1J7NA 3KEJA 2Z2DA 3SHIA 3DWBA 3HDBA 1JH1A 1CGEA 966CA 2ERPA 1OS2A 3ZUKA 3F15A 1R55A 2RJPA 3CKIA 4PKUA 4DV8A 3DTEA 1DTHA 4I03A 4AIGA 3KWVC 5B5PA 5BOTA 1GXDA 1GKCA 2MLRA 4HMAA 1HTDA 1ZXCA 2AYKA 4H82A 1YOUA 1YCMA 1C8TA 1XURA 3LJZA 4HX3A 3HDAP 1YP1A 2FV9A 2EROA 4GWMA 5I43A 1KUFA 1BKCE 1SLMA 1B8YA 2AIGP 2JNPA 1R1IA 2W13A 1G9KA 1QJJA 1DMTA 5D2BA 4ON1A 5B5OA 2OVZA 4G9LA 3KRYA 4JIJA 2WO8A 2MLSA 2W0DA 2OXWA 1QIAA 2ERQA 5D1UA 2TCLA 2OZRA 1H71P 456CA 4A3WA 1CXVA 1BKCI 4H3XA 4ILWD 4L7AA 1OO9A 1JK3A 3ELMA 3TS4A 1HY7A 1SMPA 2WOAA 5I4OA 2X7MA 4WK7A 1ZVXA 2X3CA 3L0VA 3BA0A 1PWVA 2OY2A 4GR3A 4H1QA 2OY4A 1R54A 4GWNA 4GR0A 2W14A 1XUDA 1ND1A 2WO9A 2XS3A 1XFUA 3RTTA 4IUWA 1BM6A 3HBUP 3P1VA 1JAQA 3AYKA 1QUAA 4XBHA 1S4BP 1YQYA 2JT5A 2OW2A 1I73A 1OM7A 1K7QA 3WV2A 1GE7A 4EFSA 1KAPP 2Y6DA 3TVCA 1ZXVA 3N2VA 1WNIA 2V4BA 1XUCA 1BSWA 1KUKA 3LUNA 4L19A 1GO8P 3DTIA 1B3DA 1L6JA 4FVLA 5CXAA 1ZS0A 1G4KA 2D1NA 3RTSA 1MNCA 3LJGA 1HFSA 1BKCA 1SRPA 1BUVM 3V96B 2W15A 4WZVA 1USNA 3EDIA 2J0TA 4L63A 1Z3JA 2RJQA 1EUBA 1CGLA 3B2ZA 1IAAA 1XFYA 4L6TA 2OXUA 1ASTA 3DL1A 3K7NA 1JANA 1GE5A 4CTHA 3I7IA 2MZIA 4H2EA 1A85A 1PWQA 3E8RA 1KUIA 4PKQA 5BOYA 1QJIA 1G05A 3Q2HA 3KHIA 3TSKA 1BQQM 4PKTA 1OMJA 4H30A 3F17A 1SLNA 3MA2A 1PWWA 2N8RA 1PWPA 2USNA 4A7BA 4XM7A 2HU6A 3VI1A 830CA 4IJOA 1IAGA 1OM6A 3TT4A 5H8XA 1AYKA 2XS4A 1G12A 3Q2GA 3WV3A 4FXYP 1CAQA 2K2GA 5D7WA 1KUGA 1A86A 3KMCA 3HY7A 3KMEA 4PKSA 3LQBA 1Y93A 3EDGA 4WKIA 3AIGA 3UVCA 1CK7A 3LK8A 3O64A 4FXQA 1FLSA 3LEAA 4FU4A 5CZMA 2W12A 1QICA 1JIWP 4DPEA 1ZP5A 2CLTA 2A8HA 4GQLA 1RMZA 1HFCA 2YIGA 1EB6A 1UEAA 3OHOA 3U1RA 4AXQA 1SATA 3G5CA 3B92A 1CIZA 2YB9A 1UTZA 2QPJA 3G42A 5JMYA 2K9CA 1RM8A 4DF9A 1EAKA 1D5JA 4XM6A 3LILA 1MMRA 3KEKA 1IADA 1JAOA 4WKEA 4R3VA 1K7IA 2OI0A 4PKRA 1OS9A 2JSDA 1D8MA 2FV5A 3DNGA 3ZXHA 5D1TA 2JT6A 4Q1LA 1ZTQA 1UMTA 1D8FA 3F19A 1C3IA 2E2DA 2I47A 1MMPA 4QKZA 1OM8A 1XFXA 3DPFA 1AKLA 2DDYA 1JAPA 3LMCA 4I35A 1BQOA 3EDZA 3EHXA 2POJA 3HY9A 2O3EA 1ATLA 1ROSA 2DW0A 3DTKA 1BZSA 1R1JA 1C7KA 3KECA 3EWJA 3LGPA 1BUDA 1CQRA 1MMQA 3L0TA 2KRJA 2E3XA 1XFWA 2X3BA 3P24A 4G0DA 2OVXA 4GUYA 1PWUA 1XFVA 4H84A 2O36A 3I7GA 2MZEA 2JIHA 1KBCA 2OXZA 2MZHA 2X3AA 1GKDA 1GE6A 3OHLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3ZVS A;  3VTG A;  3NX7 A;  1Q3A A;  4JP4 A;  1IAC A;  1XFZ A;  3LKA A;  4XCT A;  5LAB A;  4AUO A;  1UMS A;  3AYU A;  1O0Q A;  1UTT A;  3K7L A;  4GR8 A;  1MMB A;  1O0T A;  1GO7 P;  2L0R A;  2D1O A;  1BIW A;  5D1S A;  5L7F A;  3B8Z A;  3O2X A;  1HV5 A;  2CKI A;  4DD8 A;  3LQ0 A;  3F1A A;  4ZR5 A;  1JKY A;  4GF1 A;  4IN9 A;  5I12 A;  3F18 A;  3HYG A;  1AF0 A;  2DDF A;  4PKV A;  3EDH A;  1Y0V A;  1K7G A;  1D7X A;  1SU3 A;  1QIB A;  1IAB A;  3WV1 A;  3LIR A;  5CUH A;  3DSL A;  1HOV A;  5I3M A;  5I2Z A;  2SRT A;  4PKW A;  3LE9 A;  4J4M A;  4H76 A;  3N2U A;  3LUM A;  4XM8 A;  5L79 A;  1FM1 A;  1G49 A;  2J83 A;  2DW1 A;  3GBO A;  1IAE A;  4WF6 A;  5D3C A;  5BPA A;  2PJT A;  4AYK A;  3HB2 P;  2OW1 A;  3LIK A;  2OW9 A;  4JA1 A;  1I76 A;  1KUH A;  1R1H A;  2Y6C A;  1CGF A;  4JQG A;  3HBV P;  2DW2 A;  3USN A;  3LJT A;  3EHY A;  4H49 A;  1JIZ A;  1JJ9 A;  3F16 A;  1FBL A;  4JPA A;  3DPE A;  5I0L A;  1I1I P;  2OW0 A;  1Y8J A;  1J7N A;  3KEJ A;  2Z2D A;  3SHI A;  3DWB A;  3HDB A;  1JH1 A;  1CGE A;  966C A;  2ERP A;  1OS2 A;  3ZUK A;  3F15 A;  1R55 A;  2RJP A;  3CKI A;  4PKU A;  4DV8 A;  1DTH A;  4I03 A;  4AIG A;  3KWV C;  5B5P A;  5BOT A;  1GXD A;  1GKC A;  2MLR A;  4HMA A;  1HTD A;  1ZXC A;  2AYK A;  4H82 A;  1YOU A;  1YCM A;  1C8T A;  1XUR A;  3LJZ A;  4HX3 A;  3HDA P;  1YP1 A;  2FV9 A;  2ERO A;  4GWM A;  5I43 A;  1KUF A;  1BKC E;  1SLM A;  1B8Y A;  2AIG P;  2JNP A;  1R1I A;  2W13 A;  1G9K A;  1QJJ A;  1DMT A;  5D2B A;  4ON1 A;  5B5O A;  2OVZ A;  4G9L A;  3KRY A;  4JIJ A;  2WO8 A;  2MLS A;  2W0D A;  2OXW A;  1QIA A;  2ERQ A;  5D1U A;  2TCL A;  2OZR A;  1H71 P;  456C A;  4A3W A;  1CXV A;  1BKC I;  4H3X A;  4ILW D;  1OO9 A;  1JK3 A;  3ELM A;  3TS4 A;  1HY7 A;  1SMP A;  2WOA A;  5I4O A;  2X7M A;  4WK7 A;  1ZVX A;  2X3C A;  3L0V A;  3BA0 A;  1PWV A;  2OY2 A;  4GR3 A;  4H1Q A;  2OY4 A;  1R54 A;  4GWN A;  4GR0 A;  2W14 A;  1XUD A;  1ND1 A;  2WO9 A;  2XS3 A;  1XFU A;  3RTT A;  4IUW A;  1BM6 A;  3HBU P;  3P1V A;  1JAQ A;  3AYK A;  1QUA A;  4XBH A;  1S4B P;  1YQY A;  2JT5 A;  2OW2 A;  1I73 A;  1OM7 A;  1K7Q A;  3WV2 A;  1GE7 A;  4EFS A;  1KAP P;  2Y6D A;  3TVC A;  1ZXV A;  3N2V A;  1WNI A;  2V4B A;  1XUC A;  1BSW A;  1KUK A;  3LUN A;  4L19 A;  1GO8 P;  1B3D A;  1L6J A;  4FVL A;  5CXA A;  1ZS0 A;  1G4K A;  2D1N A;  3RTS A;  1MNC A;  3LJG A;  1HFS A;  1BKC A;  1SRP A;  1BUV M;  3V96 B;  2W15 A;  4WZV A;  1USN A;  3EDI A;  2J0T A;  4L63 A;  1Z3J A;  2RJQ A;  1EUB A;  1CGL A;  3B2Z A;  1IAA A;  1XFY A;  4L6T A;  2OXU A;  1AST A;  3DL1 A;  3K7N A;  1JAN A;  1GE5 A;  4CTH A;  3I7I A;  2MZI A;  4H2E A;  1A85 A;  1PWQ A;  3E8R A;  1KUI A;  4PKQ A;  5BOY A;  1QJI A;  1G05 A;  3Q2H A;  3KHI A;  3TSK A;  1BQQ M;  4PKT A;  1OMJ A;  4H30 A;  3F17 A;  1SLN A;  3MA2 A;  1PWW A;  2N8R A;  1PWP A;  2USN A;  4A7B A;  4XM7 A;  2HU6 A;  3VI1 A;  830C A;  4IJO A;  1IAG A;  1OM6 A;  3TT4 A;  5H8X A;  1AYK A;  2XS4 A;  1G12 A;  3Q2G A;  3WV3 A;  4FXY P;  1CAQ A;  2K2G A;  5D7W A;  1KUG A;  1A86 A;  3KMC A;  3HY7 A;  3KME A;  4PKS A;  3LQB A;  1Y93 A;  3EDG A;  4WKI A;  3AIG A;  3UVC A;  1CK7 A;  3LK8 A;  3O64 A;  4FXQ A;  1FLS A;  3LEA A;  4FU4 A;  5CZM A;  2W12 A;  1QIC A;  1JIW P;  4DPE A;  1ZP5 A;  2CLT A;  2A8H A;  4GQL A;  1RMZ A;  1HFC A;  2YIG A;  1EB6 A;  1UEA A;  3OHO A;  3U1R A;  4AXQ A;  1SAT A;  3G5C A;  3B92 A;  1CIZ A;  2YB9 A;  1UTZ A;  2QPJ A;  3G42 A;  5JMY A;  2K9C A;  1RM8 A;  4DF9 A;  1EAK A;  1D5J A;  4XM6 A;  3LIL A;  1MMR A;  3KEK A;  1IAD A;  1JAO A;  4WKE A;  4R3V A;  1K7I A;  2OI0 A;  4PKR A;  1OS9 A;  2JSD A;  1D8M A;  2FV5 A;  3DNG A;  3ZXH A;  5D1T A;  2JT6 A;  4Q1L A;  1ZTQ A;  1UMT A;  1D8F A;  3F19 A;  1C3I A;  2E2D A;  2I47 A;  1MMP A;  4QKZ A;  1OM8 A;  1XFX A;  3DPF A;  1AKL A;  2DDY A;  1JAP A;  3LMC A;  4I35 A;  1BQO A;  3EDZ A;  3EHX A;  2POJ A;  3HY9 A;  2O3E A;  1ATL A;  1ROS A;  2DW0 A;  1BZS A;  1R1J A;  1C7K A;  3KEC A;  3EWJ A;  3LGP A;  1BUD A;  1CQR A;  1MMQ A;  3L0T A;  2KRJ A;  2E3X A;  1XFW A;  2X3B A;  3P24 A;  4G0D A;  2OVX A;  4GUY A;  1PWU A;  1XFV A;  4H84 A;  2O36 A;  3I7G A;  2MZE A;  2JIH A;  1KBC A;  2OXZ A;  2MZH A;  2X3A A;  1GKD A;  1GE6 A;  3OHL A; 
#chains in the Genus database with same CATH topology
 3ZVS A;  3VTG A;  3NX7 A;  1Q3A A;  4JP4 A;  1IAC A;  1XFZ A;  3LKA A;  4XCT A;  5LAB A;  4AUO A;  1UMS A;  3AYU A;  1O0Q A;  1UTT A;  3K7L A;  4GR8 A;  1MMB A;  1O0T A;  1GO7 P;  2L0R A;  2D1O A;  1BIW A;  5D1S A;  5L7F A;  3B8Z A;  3O2X A;  1HV5 A;  2CKI A;  4DD8 A;  3LQ0 A;  3F1A A;  4ZR5 A;  1JKY A;  4GF1 A;  4IN9 A;  5I12 A;  3F18 A;  3HYG A;  1AF0 A;  2DDF A;  4PKV A;  3EDH A;  1Y0V A;  1K7G A;  1D7X A;  1SU3 A;  1QIB A;  1IAB A;  3WV1 A;  3LIR A;  5CUH A;  3DSL A;  1HOV A;  5I3M A;  5I2Z A;  2SRT A;  4PKW A;  3LE9 A;  4J4M A;  4H76 A;  3N2U A;  3LUM A;  4XM8 A;  5L79 A;  1FM1 A;  1G49 A;  2J83 A;  2DW1 A;  3GBO A;  1IAE A;  4WF6 A;  2YUF A;  5D3C A;  5BPA A;  2PJT A;  4AYK A;  3HB2 P;  2OW1 A;  3LIK A;  2OW9 A;  4JA1 A;  1I76 A;  1KUH A;  1R1H A;  2Y6C A;  1CGF A;  4JQG A;  3HBV P;  2DW2 A;  3USN A;  3LJT A;  3EHY A;  4H49 A;  1JIZ A;  1JJ9 A;  3F16 A;  1FBL A;  4JPA A;  3DPE A;  5I0L A;  1I1I P;  2OW0 A;  1Y8J A;  1J7N A;  3KEJ A;  2Z2D A;  3SHI A;  3DWB A;  3HDB A;  1JH1 A;  1CGE A;  966C A;  2ERP A;  1OS2 A;  3ZUK A;  3F15 A;  1R55 A;  2RJP A;  3CKI A;  4PKU A;  4DV8 A;  3DTE A;  1DTH A;  4I03 A;  4AIG A;  3KWV C;  5B5P A;  5BOT A;  1GXD A;  1GKC A;  2MLR A;  4HMA A;  1HTD A;  1ZXC A;  2AYK A;  4H82 A;  1YOU A;  1YCM A;  1C8T A;  1XUR A;  3LJZ A;  4HX3 A;  3HDA P;  1YP1 A;  2FV9 A;  2ERO A;  4GWM A;  5I43 A;  1KUF A;  1BKC E;  1SLM A;  1B8Y A;  2AIG P;  2JNP A;  1R1I A;  2W13 A;  1G9K A;  1QJJ A;  1DMT A;  5D2B A;  4ON1 A;  5B5O A;  2OVZ A;  4G9L A;  3KRY A;  4JIJ A;  2WO8 A;  2MLS A;  2W0D A;  2OXW A;  1QIA A;  2ERQ A;  5D1U A;  2TCL A;  2OZR A;  1H71 P;  456C A;  4A3W A;  1CXV A;  1BKC I;  4H3X A;  4ILW D;  4L7A A;  1OZ9 A;  1OO9 A;  1JK3 A;  3ELM A;  3TS4 A;  1HY7 A;  1SMP A;  2WOA A;  5I4O A;  2X7M A;  4WK7 A;  1ZVX A;  2X3C A;  3L0V A;  3BA0 A;  1PWV A;  2OY2 A;  4GR3 A;  4H1Q A;  2OY4 A;  1R54 A;  4GWN A;  4GR0 A;  2W14 A;  1XUD A;  1ND1 A;  2WO9 A;  2XS3 A;  1XFU A;  3RTT A;  4IUW A;  1BM6 A;  3HBU P;  3P1V A;  1JAQ A;  3AYK A;  1QUA A;  4XBH A;  1S4B P;  1YQY A;  2JT5 A;  2OW2 A;  1I73 A;  1OM7 A;  1K7Q A;  3WV2 A;  1GE7 A;  4EFS A;  1KAP P;  2Y6D A;  3TVC A;  1ZXV A;  3N2V A;  1WNI A;  2V4B A;  1XUC A;  1BSW A;  1KUK A;  3LUN A;  4L19 A;  1GO8 P;  3DTI A;  1B3D A;  1L6J A;  4FVL A;  5CXA A;  1ZS0 A;  1G4K A;  2D1N A;  3RTS A;  1MNC A;  3LJG A;  1HFS A;  1BKC A;  1SRP A;  1BUV M;  3V96 B;  2W15 A;  4WZV A;  1USN A;  3EDI A;  2J0T A;  4L63 A;  1Z3J A;  2RJQ A;  1EUB A;  1CGL A;  3B2Z A;  1XM5 A;  1IAA A;  1XFY A;  4L6T A;  2OXU A;  1AST A;  3DL1 A;  3K7N A;  1JAN A;  1GE5 A;  4CTH A;  3I7I A;  2MZI A;  4H2E A;  1A85 A;  1PWQ A;  3E8R A;  1KUI A;  4PKQ A;  5BOY A;  1QJI A;  1G05 A;  3Q2H A;  3KHI A;  3TSK A;  1BQQ M;  4PKT A;  1OMJ A;  4H30 A;  3F17 A;  1SLN A;  3MA2 A;  1PWW A;  2N8R A;  1PWP A;  2USN A;  4A7B A;  4XM7 A;  2HU6 A;  3VI1 A;  830C A;  4IJO A;  1IAG A;  1OM6 A;  3TT4 A;  5H8X A;  1AYK A;  2XS4 A;  1G12 A;  3Q2G A;  3WV3 A;  4FXY P;  1CAQ A;  2K2G A;  5D7W A;  1KUG A;  1A86 A;  3KMC A;  3HY7 A;  3KME A;  4PKS A;  3LQB A;  1Y93 A;  3EDG A;  4WKI A;  3AIG A;  3UVC A;  1CK7 A;  3LK8 A;  3O64 A;  4FXQ A;  1FLS A;  3LEA A;  4FU4 A;  5CZM A;  2W12 A;  1QIC A;  1JIW P;  4DPE A;  1ZP5 A;  2CLT A;  2A8H A;  4GQL A;  1RMZ A;  1HFC A;  2YIG A;  1EB6 A;  1UEA A;  3OHO A;  3U1R A;  4AXQ A;  1XAX A;  1SAT A;  3G5C A;  3B92 A;  1CIZ A;  2YB9 A;  1UTZ A;  2QPJ A;  3G42 A;  5JMY A;  2K9C A;  1RM8 A;  4DF9 A;  1EAK A;  1D5J A;  4XM6 A;  3LIL A;  1MMR A;  3KEK A;  1IAD A;  1JAO A;  4WKE A;  4R3V A;  1K7I A;  2OI0 A;  4PKR A;  1OS9 A;  2JSD A;  1D8M A;  2FV5 A;  3DNG A;  3ZXH A;  5D1T A;  2JT6 A;  4Q1L A;  1ZTQ A;  1UMT A;  1D8F A;  3F19 A;  1C3I A;  2E2D A;  2I47 A;  1MMP A;  4QKZ A;  1OM8 A;  1XFX A;  3DPF A;  1AKL A;  2DDY A;  1JAP A;  3LMC A;  4I35 A;  1BQO A;  3EDZ A;  3EHX A;  2POJ A;  3HY9 A;  2O3E A;  1ATL A;  1ROS A;  2DW0 A;  3DTK A;  1BZS A;  1R1J A;  1C7K A;  3KEC A;  3EWJ A;  3LGP A;  1BUD A;  1CQR A;  1MMQ A;  3L0T A;  2KRJ A;  2E3X A;  1XFW A;  2X3B A;  3P24 A;  4G0D A;  2OVX A;  4GUY A;  1PWU A;  1XFV A;  4H84 A;  2O36 A;  3I7G A;  2MZE A;  2JIH A;  1KBC A;  1TVI A;  2OXZ A;  2MZH A;  2X3A A;  1GKD A;  1GE6 A;  3OHL A; 
#chains in the Genus database with same CATH homology
 3ZVS A;  3VTG A;  3NX7 A;  1Q3A A;  4JP4 A;  1IAC A;  1XFZ A;  3LKA A;  4XCT A;  5LAB A;  4AUO A;  1UMS A;  3AYU A;  1O0Q A;  1UTT A;  3K7L A;  4GR8 A;  1MMB A;  1O0T A;  1GO7 P;  2L0R A;  2D1O A;  1BIW A;  5D1S A;  5L7F A;  3B8Z A;  3O2X A;  1HV5 A;  2CKI A;  4DD8 A;  3LQ0 A;  3F1A A;  4ZR5 A;  1JKY A;  4GF1 A;  4IN9 A;  5I12 A;  3F18 A;  3HYG A;  1AF0 A;  2DDF A;  4PKV A;  3EDH A;  1Y0V A;  1K7G A;  1D7X A;  1SU3 A;  1QIB A;  1IAB A;  3WV1 A;  3LIR A;  5CUH A;  3DSL A;  1HOV A;  5I3M A;  5I2Z A;  2SRT A;  4PKW A;  3LE9 A;  4J4M A;  4H76 A;  3N2U A;  3LUM A;  4XM8 A;  5L79 A;  1FM1 A;  1G49 A;  2J83 A;  2DW1 A;  3GBO A;  1IAE A;  4WF6 A;  2YUF A;  5D3C A;  5BPA A;  2PJT A;  4AYK A;  3HB2 P;  2OW1 A;  3LIK A;  2OW9 A;  4JA1 A;  1I76 A;  1KUH A;  1R1H A;  2Y6C A;  1CGF A;  4JQG A;  3HBV P;  2DW2 A;  3USN A;  3LJT A;  3EHY A;  4H49 A;  1JIZ A;  1JJ9 A;  3F16 A;  1FBL A;  4JPA A;  3DPE A;  5I0L A;  1I1I P;  2OW0 A;  1Y8J A;  1J7N A;  3KEJ A;  2Z2D A;  3SHI A;  3DWB A;  3HDB A;  1JH1 A;  1CGE A;  966C A;  2ERP A;  1OS2 A;  3ZUK A;  3F15 A;  1R55 A;  2RJP A;  3CKI A;  4PKU A;  4DV8 A;  3DTE A;  1DTH A;  4I03 A;  4AIG A;  3KWV C;  5B5P A;  5BOT A;  1GXD A;  1GKC A;  2MLR A;  4HMA A;  1HTD A;  1ZXC A;  2AYK A;  4H82 A;  1YOU A;  1YCM A;  1C8T A;  1XUR A;  3LJZ A;  4HX3 A;  3HDA P;  1YP1 A;  2FV9 A;  2ERO A;  4GWM A;  5I43 A;  1KUF A;  1BKC E;  1SLM A;  1B8Y A;  2AIG P;  2JNP A;  1R1I A;  2W13 A;  1G9K A;  1QJJ A;  1DMT A;  5D2B A;  4ON1 A;  5B5O A;  2OVZ A;  4G9L A;  3KRY A;  4JIJ A;  2WO8 A;  2MLS A;  2W0D A;  2OXW A;  1QIA A;  2ERQ A;  5D1U A;  2TCL A;  2OZR A;  1H71 P;  456C A;  4A3W A;  1CXV A;  1BKC I;  4H3X A;  4ILW D;  4L7A A;  1OO9 A;  1JK3 A;  3ELM A;  3TS4 A;  1HY7 A;  1SMP A;  2WOA A;  5I4O A;  2X7M A;  4WK7 A;  1ZVX A;  2X3C A;  3L0V A;  3BA0 A;  1PWV A;  2OY2 A;  4GR3 A;  4H1Q A;  2OY4 A;  1R54 A;  4GWN A;  4GR0 A;  2W14 A;  1XUD A;  1ND1 A;  2WO9 A;  2XS3 A;  1XFU A;  3RTT A;  4IUW A;  1BM6 A;  3HBU P;  3P1V A;  1JAQ A;  3AYK A;  1QUA A;  4XBH A;  1S4B P;  1YQY A;  2JT5 A;  2OW2 A;  1I73 A;  1OM7 A;  1K7Q A;  3WV2 A;  1GE7 A;  4EFS A;  1KAP P;  2Y6D A;  3TVC A;  1ZXV A;  3N2V A;  1WNI A;  2V4B A;  1XUC A;  1BSW A;  1KUK A;  3LUN A;  4L19 A;  1GO8 P;  3DTI A;  1B3D A;  1L6J A;  4FVL A;  5CXA A;  1ZS0 A;  1G4K A;  2D1N A;  3RTS A;  1MNC A;  3LJG A;  1HFS A;  1BKC A;  1SRP A;  1BUV M;  3V96 B;  2W15 A;  4WZV A;  1USN A;  3EDI A;  2J0T A;  4L63 A;  1Z3J A;  2RJQ A;  1EUB A;  1CGL A;  3B2Z A;  1IAA A;  1XFY A;  4L6T A;  2OXU A;  1AST A;  3DL1 A;  3K7N A;  1JAN A;  1GE5 A;  4CTH A;  3I7I A;  2MZI A;  4H2E A;  1A85 A;  1PWQ A;  3E8R A;  1KUI A;  4PKQ A;  5BOY A;  1QJI A;  1G05 A;  3Q2H A;  3KHI A;  3TSK A;  1BQQ M;  4PKT A;  1OMJ A;  4H30 A;  3F17 A;  1SLN A;  3MA2 A;  1PWW A;  2N8R A;  1PWP A;  2USN A;  4A7B A;  4XM7 A;  2HU6 A;  3VI1 A;  830C A;  4IJO A;  1IAG A;  1OM6 A;  3TT4 A;  5H8X A;  1AYK A;  2XS4 A;  1G12 A;  3Q2G A;  3WV3 A;  4FXY P;  1CAQ A;  2K2G A;  5D7W A;  1KUG A;  1A86 A;  3KMC A;  3HY7 A;  3KME A;  4PKS A;  3LQB A;  1Y93 A;  3EDG A;  4WKI A;  3AIG A;  3UVC A;  1CK7 A;  3LK8 A;  3O64 A;  4FXQ A;  1FLS A;  3LEA A;  4FU4 A;  5CZM A;  2W12 A;  1QIC A;  1JIW P;  4DPE A;  1ZP5 A;  2CLT A;  2A8H A;  4GQL A;  1RMZ A;  1HFC A;  2YIG A;  1EB6 A;  1UEA A;  3OHO A;  3U1R A;  4AXQ A;  1SAT A;  3G5C A;  3B92 A;  1CIZ A;  2YB9 A;  1UTZ A;  2QPJ A;  3G42 A;  5JMY A;  2K9C A;  1RM8 A;  4DF9 A;  1EAK A;  1D5J A;  4XM6 A;  3LIL A;  1MMR A;  3KEK A;  1IAD A;  1JAO A;  4WKE A;  4R3V A;  1K7I A;  2OI0 A;  4PKR A;  1OS9 A;  2JSD A;  1D8M A;  2FV5 A;  3DNG A;  3ZXH A;  5D1T A;  2JT6 A;  4Q1L A;  1ZTQ A;  1UMT A;  1D8F A;  3F19 A;  1C3I A;  2E2D A;  2I47 A;  1MMP A;  4QKZ A;  1OM8 A;  1XFX A;  3DPF A;  1AKL A;  2DDY A;  1JAP A;  3LMC A;  4I35 A;  1BQO A;  3EDZ A;  3EHX A;  2POJ A;  3HY9 A;  2O3E A;  1ATL A;  1ROS A;  2DW0 A;  3DTK A;  1BZS A;  1R1J A;  1C7K A;  3KEC A;  3EWJ A;  3LGP A;  1BUD A;  1CQR A;  1MMQ A;  3L0T A;  2KRJ A;  2E3X A;  1XFW A;  2X3B A;  3P24 A;  4G0D A;  2OVX A;  4GUY A;  1PWU A;  1XFV A;  4H84 A;  2O36 A;  3I7G A;  2MZE A;  2JIH A;  1KBC A;  2OXZ A;  2MZH A;  2X3A A;  1GKD A;  1GE6 A;  3OHL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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