2QPJA

Human nep complexed with a bifunctional nep/dpp iv inhibitor
Total Genus 276
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
276
sequence length
696
structure length
696
Chain Sequence
GICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Neprilysin
publication title Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV.
pubmed doi rcsb
source organism Homo sapiens
total genus 276
structure length 696
sequence length 696
ec nomenclature ec 3.4.24.11: Neprilysin.
pdb deposition date 2007-07-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01431 Peptidase_M13 Peptidase family M13
A PF05649 Peptidase_M13_N Peptidase family M13
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1380.10 Mainly Alpha Orthogonal Bundle Neutral endopeptidase; domain 2 Neutral endopeptidase , domain2 2qpjA02
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 2qpjA01
3LKAA 3DWBA 2X3AA 1YOUA 1PWQA 4GR8A 3L0VA 4XM8A 1SMPA 1EAKA 5LABA 2OVZA 3EDIA 1MNCA 1FM1A 1D8MA 1JK3A 1ROSA 4GR0A 3OHOA 2DDYA 4H82A 1G05A 1IADA 1GE5A 4PKSA 4PKRA 5I4OA 2DW0A 4PKQA 4EFSA 2EROA 1A85A 1B3DA 4FXYP 2ERPA 3B8ZA 1I73A 1BZSA 1D8FA 1QUAA 3B2ZA 456CA 1J7NA 1OM6A 2PJTA 2OXUA 1ZXCA 4IJOA 3EDZA 3TT4A 1CGEA 1YP1A 2W14A 3MA2A 3LQBA 3WV3A 3F16A 5I3MA 3E8RA 4WKEA 5L79A 3LQ0A 5B5OA 2QPJA 1ATLA 3KRYA 1R54A 2X7MA 1CK7A 2OZRA 5CXAA 1JANA 2O36A 1RMZA 1BM6A 5CUHA 2N8RA 1CQRA 4ZR5A 4HX3A 3VTGA 3P24A 1EUBA 2AYKA 2OW9A 3I7GA 1O0TA 1G49A 1JIWP 3SHIA 3LILA 1CIZA 3HBVP 3KECA 4H49A 5D7WA 5I0LA 1HY7A 4AXQA 4DD8A 1BUVM 1QICA 2RJQA 1BIWA 4H84A 2DW2A 3KEKA 1KBCA 4R3VA 3LMCA 4WF6A 3KMCA 2MLRA 3EWJA 3WV1A 1I76A 3F19A 830CA 2W15A 4DF9A 1XURA 1GE7A 4FU4A 4JA1A 1CAQA 1KUKA 2JT6A 4A3WA 2OI0A 3G42A 3EHXA 1ZXVA 4XM6A 1D5JA 1BKCE 1AF0A 3EDHA 1JKYA 2JT5A 1CGFA 1ZTQA 2XS4A 3VI1A 3F18A 1BKCA 2X3BA 1IAEA 1PWVA 4GF1A 3B92A 1KUIA 2CLTA 4L63A 2JIHA 1ND1A 1IACA 4L6TA 4GWNA 4H2EA 3TS4A 1BUDA 3CKIA 3EDGA 5BPAA 1B8YA 1ZVXA 3HDAP 1HOVA 1ASTA 1AYKA 4L19A 3RTSA 2WO9A 4AUOA 2OY4A 1YQYA 2XS3A 2V4BA 4PKUA 1MMBA 1O0QA 4FXQA 1Y8JA 2POJA 1GO8P 1R55A 1BKCI 5D2BA 3DSLA 1L6JA 1MMPA 4JIJA 2J0TA 4CTHA 3F15A 4GQLA 1HFCA 3AYUA 1OMJA 2ERQA 4HMAA 1D7XA 2E3XA 5D1TA 3K7NA 3U1RA 3HB2P 1XFXA 1QIAA 4XCTA 3KWVC 3ELMA 1OO9A 1QJIA 4PKTA 1JIZA 2X3CA 2YIGA 4WK7A 2USNA 3N2VA 1C3IA 1XUCA 1Q3AA 1Y93A 3P1VA 3UVCA 1RM8A 2WOAA 4H30A 1CGLA 4J4MA 2MZIA 1UTZA 3HBUP 2E2DA 1JJ9A 2FV5A 3AYKA 3Q2GA 2OXZA 3KEJA 2MLSA 3LJZA 3LK8A 2MZHA 1K7QA 4IUWA 5H8XA 5I12A 4AIGA 1Z3JA 1BQQM 3LGPA 3LUNA 3BA0A 1HV5A 5L7FA 4H3XA 2D1OA 3EHYA 1QJJA 2W12A 1EB6A 2Y6DA 1MMRA 4H1QA 3DNGA 2RJPA 3Q2HA 3L0TA 3G5CA 2MZEA 3LE9A 1PWUA 2Y6CA 4ON1A 5D1UA 1JAQA 3TVCA 4PKVA 1SATA 4G0DA 2WO8A 1XFZA 1OS9A 1K7GA 1S4BP 3NX7A 1KAPP 1MMQA 1XFYA 5BOTA 4GWMA 3OHLA 1Y0VA 5D3CA 2K9CA 1ZS0A 2OW1A 4PKWA 1BSWA 1KUGA 1GE6A 2DW1A 2OVXA 3V96B 4H76A 2A8HA 1DTHA 1G4KA 4XBHA 1FLSA 5B5PA 2FV9A 1WNIA 2YB9A 2SRTA 2W13A 3F1AA 1C7KA 1OM8A 3DL1A 1JAPA 3HYGA 1OM7A 1UEAA 1XFUA 1SU3A 1UTTA 3N2UA 4DV8A 3KMEA 1GO7P 1SLNA 3LJTA 3K7LA 1QIBA 1FBLA 4WZVA 1GXDA 1KUHA 1IABA 2AIGP 3DPFA 1KUFA 4JPAA 4JP4A 1C8TA 1R1HA 2O3EA 1DMTA 2TCLA 3LEAA 1YCMA 3I7IA 1SLMA 3DPEA 3ZVSA 2L0RA 5BOYA 4QKZA 4GR3A 2KRJA 1XFWA 4ILWD 3F17A 1H71P 1HFSA 1AKLA 1K7IA 2J83A 2K2GA 4XM7A 1OS2A 1ZP5A 3AIGA 1BQOA 3O2XA 1G12A 1XFVA 3LIRA 1JH1A 1GKDA 4DPEA 1USNA 4GUYA 3USNA 4Q1LA 3KHIA 1IAAA 3GBOA 1A86A 2JNPA 4IN9A 1IAGA 2I47A 3LJGA 4I03A 5D1SA 5I43A 1XUDA 2DDFA 4JQGA 5JMYA 2OW0A 3ZXHA 1JAOA 1GKCA 4AYKA 2D1NA 2Z2DA 2W0DA 2OY2A 3WV2A 1UMTA 2JSDA 4FVLA 3RTTA 1PWWA 1R1IA 3LUMA 1HTDA 3ZUKA 4WKIA 1UMSA 2OW2A 3LIKA 3HY9A 5I2ZA 3TSKA 2CKIA 1CXVA 1I1IP 2HU6A 4I35A 5CZMA 4G9LA 2OXWA 966CA 3HDBA 3HY7A 1SRPA 4A7BA 1G9KA 1R1JA 3O64A 1PWPA
chains in the Genus database with same CATH superfamily
3LKAA 3DWBA 2X3AA 1YOUA 1PWQA 4GR8A 3L0VA 4XM8A 1SMPA 1EAKA 5LABA 2OVZA 3EDIA 1MNCA 1FM1A 1D8MA 1JK3A 1ROSA 4GR0A 3OHOA 2DDYA 4H82A 1G05A 1IADA 1GE5A 4PKSA 4PKRA 5I4OA 2DW0A 4PKQA 4EFSA 2EROA 1A85A 1B3DA 4FXYP 2ERPA 3B8ZA 1I73A 3DTIA 1BZSA 1D8FA 1QUAA 3B2ZA 456CA 1J7NA 1OM6A 2PJTA 2OXUA 1ZXCA 4IJOA 3EDZA 3TT4A 1CGEA 1YP1A 2W14A 3MA2A 2YUFA 3LQBA 3WV3A 3F16A 5I3MA 3E8RA 4WKEA 5L79A 3LQ0A 5B5OA 2QPJA 1ATLA 3KRYA 1R54A 2X7MA 1CK7A 2OZRA 5CXAA 1JANA 4L7AA 2O36A 1RMZA 1BM6A 5CUHA 2N8RA 1CQRA 4ZR5A 4HX3A 3VTGA 3P24A 1EUBA 2AYKA 2OW9A 3I7GA 1O0TA 1G49A 1JIWP 3SHIA 3LILA 1CIZA 3HBVP 3KECA 4H49A 5D7WA 5I0LA 1HY7A 4AXQA 4DD8A 1BUVM 1QICA 2RJQA 1BIWA 4H84A 2DW2A 3KEKA 1KBCA 4R3VA 3LMCA 4WF6A 3KMCA 2MLRA 3EWJA 3WV1A 1I76A 3F19A 830CA 2W15A 4DF9A 1XURA 1GE7A 4FU4A 4JA1A 1CAQA 1KUKA 2JT6A 4A3WA 2OI0A 3G42A 3EHXA 1ZXVA 4XM6A 1D5JA 1BKCE 1AF0A 3DTEA 3EDHA 1JKYA 2JT5A 1CGFA 1ZTQA 2XS4A 3VI1A 3F18A 1BKCA 2X3BA 1IAEA 1PWVA 4GF1A 3B92A 1KUIA 2CLTA 4L63A 2JIHA 1ND1A 1IACA 4L6TA 4GWNA 4H2EA 3TS4A 1BUDA 3CKIA 3EDGA 5BPAA 1B8YA 1ZVXA 3HDAP 1HOVA 1ASTA 1AYKA 4L19A 3RTSA 2WO9A 4AUOA 2OY4A 1YQYA 2XS3A 2V4BA 4PKUA 1MMBA 1O0QA 4FXQA 1Y8JA 2POJA 1GO8P 1R55A 1BKCI 5D2BA 3DSLA 1L6JA 1MMPA 4JIJA 2J0TA 4CTHA 3F15A 4GQLA 1OZ9A 1HFCA 3AYUA 1OMJA 2ERQA 4HMAA 1D7XA 2E3XA 5D1TA 3K7NA 3U1RA 3HB2P 1XFXA 1QIAA 4XCTA 3KWVC 3ELMA 1OO9A 1QJIA 4PKTA 1JIZA 2X3CA 2YIGA 4WK7A 2USNA 3N2VA 1C3IA 1XUCA 1Q3AA 1Y93A 3P1VA 3UVCA 1RM8A 2WOAA 4H30A 1CGLA 4J4MA 2MZIA 1UTZA 3HBUP 2E2DA 1JJ9A 2FV5A 3AYKA 3Q2GA 2OXZA 3KEJA 2MLSA 3LJZA 3LK8A 2MZHA 3DTKA 1K7QA 4IUWA 5H8XA 5I12A 4AIGA 1Z3JA 1BQQM 3LGPA 3LUNA 3BA0A 1HV5A 5L7FA 4H3XA 2D1OA 3EHYA 1QJJA 2W12A 1EB6A 2Y6DA 1MMRA 4H1QA 3DNGA 2RJPA 3Q2HA 3L0TA 3G5CA 2MZEA 3LE9A 1PWUA 2Y6CA 4ON1A 5D1UA 1JAQA 3TVCA 4PKVA 1SATA 4G0DA 2WO8A 1XFZA 1OS9A 1K7GA 1S4BP 3NX7A 1KAPP 1MMQA 1XFYA 5BOTA 4GWMA 3OHLA 1Y0VA 5D3CA 1XM5A 2K9CA 1ZS0A 2OW1A 4PKWA 1BSWA 1KUGA 1GE6A 2DW1A 2OVXA 3V96B 4H76A 2A8HA 1DTHA 1G4KA 4XBHA 1FLSA 5B5PA 2FV9A 1WNIA 2YB9A 2SRTA 2W13A 3F1AA 1C7KA 1OM8A 3DL1A 1JAPA 3HYGA 1OM7A 1UEAA 1XFUA 1SU3A 1UTTA 3N2UA 4DV8A 3KMEA 1GO7P 1SLNA 3LJTA 3K7LA 1QIBA 1FBLA 4WZVA 1GXDA 1KUHA 1IABA 2AIGP 3DPFA 1KUFA 4JPAA 4JP4A 1C8TA 1R1HA 2O3EA 1DMTA 2TCLA 3LEAA 1YCMA 3I7IA 1SLMA 3DPEA 3ZVSA 1XAXA 2L0RA 5BOYA 4QKZA 4GR3A 2KRJA 1XFWA 4ILWD 3F17A 1H71P 1HFSA 1AKLA 1K7IA 2J83A 2K2GA 4XM7A 1OS2A 1ZP5A 3AIGA 1BQOA 3O2XA 1G12A 1XFVA 3LIRA 1JH1A 1GKDA 4DPEA 1USNA 4GUYA 3USNA 1TVIA 4Q1LA 3KHIA 1IAAA 3GBOA 1A86A 2JNPA 4IN9A 1IAGA 2I47A 3LJGA 4I03A 5D1SA 5I43A 1XUDA 2DDFA 4JQGA 5JMYA 2OW0A 3ZXHA 1JAOA 1GKCA 4AYKA 2D1NA 2Z2DA 2W0DA 2OY2A 3WV2A 1UMTA 2JSDA 4FVLA 3RTTA 1PWWA 1R1IA 3LUMA 1HTDA 3ZUKA 4WKIA 1UMSA 2OW2A 3LIKA 3HY9A 5I2ZA 3TSKA 2CKIA 1CXVA 1I1IP 2HU6A 4I35A 5CZMA 4G9LA 2OXWA 966CA 3HDBA 3HY7A 1SRPA 4A7BA 1G9KA 1R1JA 3O64A 1PWPA
chains in the Genus database with same CATH topology
3LKAA 3DWBA 2X3AA 1YOUA 1PWQA 4GR8A 3L0VA 4XM8A 1SMPA 1EAKA 5LABA 2OVZA 3EDIA 1MNCA 1FM1A 1D8MA 1JK3A 1ROSA 4GR0A 3OHOA 2DDYA 4H82A 1G05A 1IADA 1GE5A 4PKSA 4PKRA 5I4OA 2DW0A 4PKQA 4EFSA 2EROA 1A85A 1B3DA 4FXYP 2ERPA 3B8ZA 1I73A 3DTIA 1BZSA 1D8FA 1QUAA 3B2ZA 456CA 1J7NA 1OM6A 2PJTA 2OXUA 1ZXCA 4IJOA 3EDZA 3TT4A 1CGEA 1YP1A 2W14A 3MA2A 2YUFA 3LQBA 3WV3A 3F16A 5I3MA 3E8RA 4WKEA 5L79A 3LQ0A 5B5OA 2QPJA 1ATLA 3KRYA 1R54A 2X7MA 1CK7A 2OZRA 5CXAA 1JANA 4L7AA 2O36A 1RMZA 1BM6A 5CUHA 2N8RA 1CQRA 4ZR5A 4HX3A 3VTGA 3P24A 1EUBA 2AYKA 2OW9A 3I7GA 1O0TA 1G49A 1JIWP 3SHIA 3LILA 1CIZA 3HBVP 3KECA 4H49A 5D7WA 5I0LA 1HY7A 4AXQA 4DD8A 1BUVM 1QICA 2RJQA 1BIWA 4H84A 2DW2A 3KEKA 1KBCA 4R3VA 3LMCA 4WF6A 3KMCA 2MLRA 3EWJA 3WV1A 1I76A 3F19A 830CA 2W15A 4DF9A 1XURA 1GE7A 4FU4A 4JA1A 1CAQA 1KUKA 2JT6A 4A3WA 2OI0A 3G42A 3EHXA 1ZXVA 4XM6A 1D5JA 1BKCE 1AF0A 3DTEA 3EDHA 1JKYA 2JT5A 1CGFA 1ZTQA 2XS4A 3VI1A 3F18A 1BKCA 2X3BA 1IAEA 1PWVA 4GF1A 3B92A 1KUIA 2CLTA 4L63A 2JIHA 1ND1A 1IACA 4L6TA 4GWNA 4H2EA 3TS4A 1BUDA 3CKIA 3EDGA 5BPAA 1B8YA 1ZVXA 3HDAP 1HOVA 1ASTA 1AYKA 4L19A 3RTSA 2WO9A 4AUOA 2OY4A 1YQYA 2XS3A 2V4BA 4PKUA 1MMBA 1O0QA 4FXQA 1Y8JA 2POJA 1GO8P 1R55A 1BKCI 5D2BA 3DSLA 1L6JA 1MMPA 4JIJA 2J0TA 4CTHA 3F15A 4GQLA 1HFCA 3AYUA 1OMJA 2ERQA 4HMAA 1D7XA 2E3XA 5D1TA 3K7NA 3U1RA 3HB2P 1XFXA 1QIAA 4XCTA 3KWVC 3ELMA 1OO9A 1QJIA 4PKTA 1JIZA 2X3CA 2YIGA 4WK7A 2USNA 3N2VA 1C3IA 1XUCA 1Q3AA 1Y93A 3P1VA 3UVCA 1RM8A 2WOAA 4H30A 1CGLA 4J4MA 2MZIA 1UTZA 3HBUP 2E2DA 1JJ9A 2FV5A 3AYKA 3Q2GA 2OXZA 3KEJA 2MLSA 3LJZA 3LK8A 2MZHA 3DTKA 1K7QA 4IUWA 5H8XA 5I12A 4AIGA 1Z3JA 1BQQM 3LGPA 3LUNA 3BA0A 1HV5A 5L7FA 4H3XA 2D1OA 3EHYA 1QJJA 2W12A 1EB6A 2Y6DA 1MMRA 4H1QA 3DNGA 2RJPA 3Q2HA 3L0TA 3G5CA 2MZEA 3LE9A 1PWUA 2Y6CA 4ON1A 5D1UA 1JAQA 3TVCA 4PKVA 1SATA 4G0DA 2WO8A 1XFZA 1OS9A 1K7GA 1S4BP 3NX7A 1KAPP 1MMQA 1XFYA 5BOTA 4GWMA 3OHLA 1Y0VA 5D3CA 2K9CA 1ZS0A 2OW1A 4PKWA 1BSWA 1KUGA 1GE6A 2DW1A 2OVXA 3V96B 4H76A 2A8HA 1DTHA 1G4KA 4XBHA 1FLSA 5B5PA 2FV9A 1WNIA 2YB9A 2SRTA 2W13A 3F1AA 1C7KA 1OM8A 3DL1A 1JAPA 3HYGA 1OM7A 1UEAA 1XFUA 1SU3A 1UTTA 3N2UA 4DV8A 3KMEA 1GO7P 1SLNA 3LJTA 3K7LA 1QIBA 1FBLA 4WZVA 1GXDA 1KUHA 1IABA 2AIGP 3DPFA 1KUFA 4JPAA 4JP4A 1C8TA 1R1HA 2O3EA 1DMTA 2TCLA 3LEAA 1YCMA 3I7IA 1SLMA 3DPEA 3ZVSA 2L0RA 5BOYA 4QKZA 4GR3A 2KRJA 1XFWA 4ILWD 3F17A 1H71P 1HFSA 1AKLA 1K7IA 2J83A 2K2GA 4XM7A 1OS2A 1ZP5A 3AIGA 1BQOA 3O2XA 1G12A 1XFVA 3LIRA 1JH1A 1GKDA 4DPEA 1USNA 4GUYA 3USNA 4Q1LA 3KHIA 1IAAA 3GBOA 1A86A 2JNPA 4IN9A 1IAGA 2I47A 3LJGA 4I03A 5D1SA 5I43A 1XUDA 2DDFA 4JQGA 5JMYA 2OW0A 3ZXHA 1JAOA 1GKCA 4AYKA 2D1NA 2Z2DA 2W0DA 2OY2A 3WV2A 1UMTA 2JSDA 4FVLA 3RTTA 1PWWA 1R1IA 3LUMA 1HTDA 3ZUKA 4WKIA 1UMSA 2OW2A 3LIKA 3HY9A 5I2ZA 3TSKA 2CKIA 1CXVA 1I1IP 2HU6A 4I35A 5CZMA 4G9LA 2OXWA 966CA 3HDBA 3HY7A 1SRPA 4A7BA 1G9KA 1R1JA 3O64A 1PWPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LKA A;  3DWB A;  2X3A A;  1YOU A;  1PWQ A;  4GR8 A;  3L0V A;  4XM8 A;  1SMP A;  1EAK A;  5LAB A;  2OVZ A;  3EDI A;  1MNC A;  1FM1 A;  1D8M A;  1JK3 A;  1ROS A;  4GR0 A;  3OHO A;  2DDY A;  4H82 A;  1G05 A;  1IAD A;  1GE5 A;  4PKS A;  4PKR A;  5I4O A;  2DW0 A;  4PKQ A;  4EFS A;  2ERO A;  1A85 A;  1B3D A;  4FXY P;  2ERP A;  3B8Z A;  1I73 A;  1BZS A;  1D8F A;  1QUA A;  3B2Z A;  456C A;  1J7N A;  1OM6 A;  2PJT A;  2OXU A;  1ZXC A;  4IJO A;  3EDZ A;  3TT4 A;  1CGE A;  1YP1 A;  2W14 A;  3MA2 A;  3LQB A;  3WV3 A;  3F16 A;  5I3M A;  3E8R A;  4WKE A;  5L79 A;  3LQ0 A;  5B5O A;  2QPJ A;  1ATL A;  3KRY A;  1R54 A;  2X7M A;  1CK7 A;  2OZR A;  5CXA A;  1JAN A;  2O36 A;  1RMZ A;  1BM6 A;  5CUH A;  2N8R A;  1CQR A;  4ZR5 A;  4HX3 A;  3VTG A;  3P24 A;  1EUB A;  2AYK A;  2OW9 A;  3I7G A;  1O0T A;  1G49 A;  1JIW P;  3SHI A;  3LIL A;  1CIZ A;  3HBV P;  3KEC A;  4H49 A;  5D7W A;  5I0L A;  1HY7 A;  4AXQ A;  4DD8 A;  1BUV M;  1QIC A;  2RJQ A;  1BIW A;  4H84 A;  2DW2 A;  3KEK A;  1KBC A;  4R3V A;  3LMC A;  4WF6 A;  3KMC A;  2MLR A;  3EWJ A;  3WV1 A;  1I76 A;  3F19 A;  830C A;  2W15 A;  4DF9 A;  1XUR A;  1GE7 A;  4FU4 A;  4JA1 A;  1CAQ A;  1KUK A;  2JT6 A;  4A3W A;  2OI0 A;  3G42 A;  3EHX A;  1ZXV A;  4XM6 A;  1D5J A;  1BKC E;  1AF0 A;  3EDH A;  1JKY A;  2JT5 A;  1CGF A;  1ZTQ A;  2XS4 A;  3VI1 A;  3F18 A;  1BKC A;  2X3B A;  1IAE A;  1PWV A;  4GF1 A;  3B92 A;  1KUI A;  2CLT A;  4L63 A;  2JIH A;  1ND1 A;  1IAC A;  4L6T A;  4GWN A;  4H2E A;  3TS4 A;  1BUD A;  3CKI A;  3EDG A;  5BPA A;  1B8Y A;  1ZVX A;  3HDA P;  1HOV A;  1AST A;  1AYK A;  4L19 A;  3RTS A;  2WO9 A;  4AUO A;  2OY4 A;  1YQY A;  2XS3 A;  2V4B A;  4PKU A;  1MMB A;  1O0Q A;  4FXQ A;  1Y8J A;  2POJ A;  1GO8 P;  1R55 A;  1BKC I;  5D2B A;  3DSL A;  1L6J A;  1MMP A;  4JIJ A;  2J0T A;  4CTH A;  3F15 A;  4GQL A;  1HFC A;  3AYU A;  1OMJ A;  2ERQ A;  4HMA A;  1D7X A;  2E3X A;  5D1T A;  3K7N A;  3U1R A;  3HB2 P;  1XFX A;  1QIA A;  4XCT A;  3KWV C;  3ELM A;  1OO9 A;  1QJI A;  4PKT A;  1JIZ A;  2X3C A;  2YIG A;  4WK7 A;  2USN A;  3N2V A;  1C3I A;  1XUC A;  1Q3A A;  1Y93 A;  3P1V A;  3UVC A;  1RM8 A;  2WOA A;  4H30 A;  1CGL A;  4J4M A;  2MZI A;  1UTZ A;  3HBU P;  2E2D A;  1JJ9 A;  2FV5 A;  3AYK A;  3Q2G A;  2OXZ A;  3KEJ A;  2MLS A;  3LJZ A;  3LK8 A;  2MZH A;  1K7Q A;  4IUW A;  5H8X A;  5I12 A;  4AIG A;  1Z3J A;  1BQQ M;  3LGP A;  3LUN A;  3BA0 A;  1HV5 A;  5L7F A;  4H3X A;  2D1O A;  3EHY A;  1QJJ A;  2W12 A;  1EB6 A;  2Y6D A;  1MMR A;  4H1Q A;  3DNG A;  2RJP A;  3Q2H A;  3L0T A;  3G5C A;  2MZE A;  3LE9 A;  1PWU A;  2Y6C A;  4ON1 A;  5D1U A;  1JAQ A;  3TVC A;  4PKV A;  1SAT A;  4G0D A;  2WO8 A;  1XFZ A;  1OS9 A;  1K7G A;  1S4B P;  3NX7 A;  1KAP P;  1MMQ A;  1XFY A;  5BOT A;  4GWM A;  3OHL A;  1Y0V A;  5D3C A;  2K9C A;  1ZS0 A;  2OW1 A;  4PKW A;  1BSW A;  1KUG A;  1GE6 A;  2DW1 A;  2OVX A;  3V96 B;  4H76 A;  2A8H A;  1DTH A;  1G4K A;  4XBH A;  1FLS A;  5B5P A;  2FV9 A;  1WNI A;  2YB9 A;  2SRT A;  2W13 A;  3F1A A;  1C7K A;  1OM8 A;  3DL1 A;  1JAP A;  3HYG A;  1OM7 A;  1UEA A;  1XFU A;  1SU3 A;  1UTT A;  3N2U A;  4DV8 A;  3KME A;  1GO7 P;  1SLN A;  3LJT A;  3K7L A;  1QIB A;  1FBL A;  4WZV A;  1GXD A;  1KUH A;  1IAB A;  2AIG P;  3DPF A;  1KUF A;  4JPA A;  4JP4 A;  1C8T A;  1R1H A;  2O3E A;  1DMT A;  2TCL A;  3LEA A;  1YCM A;  3I7I A;  1SLM A;  3DPE A;  3ZVS A;  2L0R A;  5BOY A;  4QKZ A;  4GR3 A;  2KRJ A;  1XFW A;  4ILW D;  3F17 A;  1H71 P;  1HFS A;  1AKL A;  1K7I A;  2J83 A;  2K2G A;  4XM7 A;  1OS2 A;  1ZP5 A;  3AIG A;  1BQO A;  3O2X A;  1G12 A;  1XFV A;  3LIR A;  1JH1 A;  1GKD A;  4DPE A;  1USN A;  4GUY A;  3USN A;  4Q1L A;  3KHI A;  1IAA A;  3GBO A;  1A86 A;  2JNP A;  4IN9 A;  1IAG A;  2I47 A;  3LJG A;  4I03 A;  5D1S A;  5I43 A;  1XUD A;  2DDF A;  4JQG A;  5JMY A;  2OW0 A;  3ZXH A;  1JAO A;  1GKC A;  4AYK A;  2D1N A;  2Z2D A;  2W0D A;  2OY2 A;  3WV2 A;  1UMT A;  2JSD A;  4FVL A;  3RTT A;  1PWW A;  1R1I A;  3LUM A;  1HTD A;  3ZUK A;  4WKI A;  1UMS A;  2OW2 A;  3LIK A;  3HY9 A;  5I2Z A;  3TSK A;  2CKI A;  1CXV A;  1I1I P;  2HU6 A;  4I35 A;  5CZM A;  4G9L A;  2OXW A;  966C A;  3HDB A;  3HY7 A;  1SRP A;  4A7B A;  1G9K A;  1R1J A;  3O64 A;  1PWP A; 
#chains in the Genus database with same CATH topology
 3LKA A;  3DWB A;  2X3A A;  1YOU A;  1PWQ A;  4GR8 A;  3L0V A;  4XM8 A;  1SMP A;  1EAK A;  5LAB A;  2OVZ A;  3EDI A;  1MNC A;  1FM1 A;  1D8M A;  1JK3 A;  1ROS A;  4GR0 A;  3OHO A;  2DDY A;  4H82 A;  1G05 A;  1IAD A;  1GE5 A;  4PKS A;  4PKR A;  5I4O A;  2DW0 A;  4PKQ A;  4EFS A;  2ERO A;  1A85 A;  1B3D A;  4FXY P;  2ERP A;  3B8Z A;  1I73 A;  3DTI A;  1BZS A;  1D8F A;  1QUA A;  3B2Z A;  456C A;  1J7N A;  1OM6 A;  2PJT A;  2OXU A;  1ZXC A;  4IJO A;  3EDZ A;  3TT4 A;  1CGE A;  1YP1 A;  2W14 A;  3MA2 A;  2YUF A;  3LQB A;  3WV3 A;  3F16 A;  5I3M A;  3E8R A;  4WKE A;  5L79 A;  3LQ0 A;  5B5O A;  2QPJ A;  1ATL A;  3KRY A;  1R54 A;  2X7M A;  1CK7 A;  2OZR A;  5CXA A;  1JAN A;  4L7A A;  2O36 A;  1RMZ A;  1BM6 A;  5CUH A;  2N8R A;  1CQR A;  4ZR5 A;  4HX3 A;  3VTG A;  3P24 A;  1EUB A;  2AYK A;  2OW9 A;  3I7G A;  1O0T A;  1G49 A;  1JIW P;  3SHI A;  3LIL A;  1CIZ A;  3HBV P;  3KEC A;  4H49 A;  5D7W A;  5I0L A;  1HY7 A;  4AXQ A;  4DD8 A;  1BUV M;  1QIC A;  2RJQ A;  1BIW A;  4H84 A;  2DW2 A;  3KEK A;  1KBC A;  4R3V A;  3LMC A;  4WF6 A;  3KMC A;  2MLR A;  3EWJ A;  3WV1 A;  1I76 A;  3F19 A;  830C A;  2W15 A;  4DF9 A;  1XUR A;  1GE7 A;  4FU4 A;  4JA1 A;  1CAQ A;  1KUK A;  2JT6 A;  4A3W A;  2OI0 A;  3G42 A;  3EHX A;  1ZXV A;  4XM6 A;  1D5J A;  1BKC E;  1AF0 A;  3DTE A;  3EDH A;  1JKY A;  2JT5 A;  1CGF A;  1ZTQ A;  2XS4 A;  3VI1 A;  3F18 A;  1BKC A;  2X3B A;  1IAE A;  1PWV A;  4GF1 A;  3B92 A;  1KUI A;  2CLT A;  4L63 A;  2JIH A;  1ND1 A;  1IAC A;  4L6T A;  4GWN A;  4H2E A;  3TS4 A;  1BUD A;  3CKI A;  3EDG A;  5BPA A;  1B8Y A;  1ZVX A;  3HDA P;  1HOV A;  1AST A;  1AYK A;  4L19 A;  3RTS A;  2WO9 A;  4AUO A;  2OY4 A;  1YQY A;  2XS3 A;  2V4B A;  4PKU A;  1MMB A;  1O0Q A;  4FXQ A;  1Y8J A;  2POJ A;  1GO8 P;  1R55 A;  1BKC I;  5D2B A;  3DSL A;  1L6J A;  1MMP A;  4JIJ A;  2J0T A;  4CTH A;  3F15 A;  4GQL A;  1OZ9 A;  1HFC A;  3AYU A;  1OMJ A;  2ERQ A;  4HMA A;  1D7X A;  2E3X A;  5D1T A;  3K7N A;  3U1R A;  3HB2 P;  1XFX A;  1QIA A;  4XCT A;  3KWV C;  3ELM A;  1OO9 A;  1QJI A;  4PKT A;  1JIZ A;  2X3C A;  2YIG A;  4WK7 A;  2USN A;  3N2V A;  1C3I A;  1XUC A;  1Q3A A;  1Y93 A;  3P1V A;  3UVC A;  1RM8 A;  2WOA A;  4H30 A;  1CGL A;  4J4M A;  2MZI A;  1UTZ A;  3HBU P;  2E2D A;  1JJ9 A;  2FV5 A;  3AYK A;  3Q2G A;  2OXZ A;  3KEJ A;  2MLS A;  3LJZ A;  3LK8 A;  2MZH A;  3DTK A;  1K7Q A;  4IUW A;  5H8X A;  5I12 A;  4AIG A;  1Z3J A;  1BQQ M;  3LGP A;  3LUN A;  3BA0 A;  1HV5 A;  5L7F A;  4H3X A;  2D1O A;  3EHY A;  1QJJ A;  2W12 A;  1EB6 A;  2Y6D A;  1MMR A;  4H1Q A;  3DNG A;  2RJP A;  3Q2H A;  3L0T A;  3G5C A;  2MZE A;  3LE9 A;  1PWU A;  2Y6C A;  4ON1 A;  5D1U A;  1JAQ A;  3TVC A;  4PKV A;  1SAT A;  4G0D A;  2WO8 A;  1XFZ A;  1OS9 A;  1K7G A;  1S4B P;  3NX7 A;  1KAP P;  1MMQ A;  1XFY A;  5BOT A;  4GWM A;  3OHL A;  1Y0V A;  5D3C A;  1XM5 A;  2K9C A;  1ZS0 A;  2OW1 A;  4PKW A;  1BSW A;  1KUG A;  1GE6 A;  2DW1 A;  2OVX A;  3V96 B;  4H76 A;  2A8H A;  1DTH A;  1G4K A;  4XBH A;  1FLS A;  5B5P A;  2FV9 A;  1WNI A;  2YB9 A;  2SRT A;  2W13 A;  3F1A A;  1C7K A;  1OM8 A;  3DL1 A;  1JAP A;  3HYG A;  1OM7 A;  1UEA A;  1XFU A;  1SU3 A;  1UTT A;  3N2U A;  4DV8 A;  3KME A;  1GO7 P;  1SLN A;  3LJT A;  3K7L A;  1QIB A;  1FBL A;  4WZV A;  1GXD A;  1KUH A;  1IAB A;  2AIG P;  3DPF A;  1KUF A;  4JPA A;  4JP4 A;  1C8T A;  1R1H A;  2O3E A;  1DMT A;  2TCL A;  3LEA A;  1YCM A;  3I7I A;  1SLM A;  3DPE A;  3ZVS A;  1XAX A;  2L0R A;  5BOY A;  4QKZ A;  4GR3 A;  2KRJ A;  1XFW A;  4ILW D;  3F17 A;  1H71 P;  1HFS A;  1AKL A;  1K7I A;  2J83 A;  2K2G A;  4XM7 A;  1OS2 A;  1ZP5 A;  3AIG A;  1BQO A;  3O2X A;  1G12 A;  1XFV A;  3LIR A;  1JH1 A;  1GKD A;  4DPE A;  1USN A;  4GUY A;  3USN A;  1TVI A;  4Q1L A;  3KHI A;  1IAA A;  3GBO A;  1A86 A;  2JNP A;  4IN9 A;  1IAG A;  2I47 A;  3LJG A;  4I03 A;  5D1S A;  5I43 A;  1XUD A;  2DDF A;  4JQG A;  5JMY A;  2OW0 A;  3ZXH A;  1JAO A;  1GKC A;  4AYK A;  2D1N A;  2Z2D A;  2W0D A;  2OY2 A;  3WV2 A;  1UMT A;  2JSD A;  4FVL A;  3RTT A;  1PWW A;  1R1I A;  3LUM A;  1HTD A;  3ZUK A;  4WKI A;  1UMS A;  2OW2 A;  3LIK A;  3HY9 A;  5I2Z A;  3TSK A;  2CKI A;  1CXV A;  1I1I P;  2HU6 A;  4I35 A;  5CZM A;  4G9L A;  2OXW A;  966C A;  3HDB A;  3HY7 A;  1SRP A;  4A7B A;  1G9K A;  1R1J A;  3O64 A;  1PWP A; 
#chains in the Genus database with same CATH homology
 3LKA A;  3DWB A;  2X3A A;  1YOU A;  1PWQ A;  4GR8 A;  3L0V A;  4XM8 A;  1SMP A;  1EAK A;  5LAB A;  2OVZ A;  3EDI A;  1MNC A;  1FM1 A;  1D8M A;  1JK3 A;  1ROS A;  4GR0 A;  3OHO A;  2DDY A;  4H82 A;  1G05 A;  1IAD A;  1GE5 A;  4PKS A;  4PKR A;  5I4O A;  2DW0 A;  4PKQ A;  4EFS A;  2ERO A;  1A85 A;  1B3D A;  4FXY P;  2ERP A;  3B8Z A;  1I73 A;  3DTI A;  1BZS A;  1D8F A;  1QUA A;  3B2Z A;  456C A;  1J7N A;  1OM6 A;  2PJT A;  2OXU A;  1ZXC A;  4IJO A;  3EDZ A;  3TT4 A;  1CGE A;  1YP1 A;  2W14 A;  3MA2 A;  2YUF A;  3LQB A;  3WV3 A;  3F16 A;  5I3M A;  3E8R A;  4WKE A;  5L79 A;  3LQ0 A;  5B5O A;  2QPJ A;  1ATL A;  3KRY A;  1R54 A;  2X7M A;  1CK7 A;  2OZR A;  5CXA A;  1JAN A;  4L7A A;  2O36 A;  1RMZ A;  1BM6 A;  5CUH A;  2N8R A;  1CQR A;  4ZR5 A;  4HX3 A;  3VTG A;  3P24 A;  1EUB A;  2AYK A;  2OW9 A;  3I7G A;  1O0T A;  1G49 A;  1JIW P;  3SHI A;  3LIL A;  1CIZ A;  3HBV P;  3KEC A;  4H49 A;  5D7W A;  5I0L A;  1HY7 A;  4AXQ A;  4DD8 A;  1BUV M;  1QIC A;  2RJQ A;  1BIW A;  4H84 A;  2DW2 A;  3KEK A;  1KBC A;  4R3V A;  3LMC A;  4WF6 A;  3KMC A;  2MLR A;  3EWJ A;  3WV1 A;  1I76 A;  3F19 A;  830C A;  2W15 A;  4DF9 A;  1XUR A;  1GE7 A;  4FU4 A;  4JA1 A;  1CAQ A;  1KUK A;  2JT6 A;  4A3W A;  2OI0 A;  3G42 A;  3EHX A;  1ZXV A;  4XM6 A;  1D5J A;  1BKC E;  1AF0 A;  3DTE A;  3EDH A;  1JKY A;  2JT5 A;  1CGF A;  1ZTQ A;  2XS4 A;  3VI1 A;  3F18 A;  1BKC A;  2X3B A;  1IAE A;  1PWV A;  4GF1 A;  3B92 A;  1KUI A;  2CLT A;  4L63 A;  2JIH A;  1ND1 A;  1IAC A;  4L6T A;  4GWN A;  4H2E A;  3TS4 A;  1BUD A;  3CKI A;  3EDG A;  5BPA A;  1B8Y A;  1ZVX A;  3HDA P;  1HOV A;  1AST A;  1AYK A;  4L19 A;  3RTS A;  2WO9 A;  4AUO A;  2OY4 A;  1YQY A;  2XS3 A;  2V4B A;  4PKU A;  1MMB A;  1O0Q A;  4FXQ A;  1Y8J A;  2POJ A;  1GO8 P;  1R55 A;  1BKC I;  5D2B A;  3DSL A;  1L6J A;  1MMP A;  4JIJ A;  2J0T A;  4CTH A;  3F15 A;  4GQL A;  1HFC A;  3AYU A;  1OMJ A;  2ERQ A;  4HMA A;  1D7X A;  2E3X A;  5D1T A;  3K7N A;  3U1R A;  3HB2 P;  1XFX A;  1QIA A;  4XCT A;  3KWV C;  3ELM A;  1OO9 A;  1QJI A;  4PKT A;  1JIZ A;  2X3C A;  2YIG A;  4WK7 A;  2USN A;  3N2V A;  1C3I A;  1XUC A;  1Q3A A;  1Y93 A;  3P1V A;  3UVC A;  1RM8 A;  2WOA A;  4H30 A;  1CGL A;  4J4M A;  2MZI A;  1UTZ A;  3HBU P;  2E2D A;  1JJ9 A;  2FV5 A;  3AYK A;  3Q2G A;  2OXZ A;  3KEJ A;  2MLS A;  3LJZ A;  3LK8 A;  2MZH A;  3DTK A;  1K7Q A;  4IUW A;  5H8X A;  5I12 A;  4AIG A;  1Z3J A;  1BQQ M;  3LGP A;  3LUN A;  3BA0 A;  1HV5 A;  5L7F A;  4H3X A;  2D1O A;  3EHY A;  1QJJ A;  2W12 A;  1EB6 A;  2Y6D A;  1MMR A;  4H1Q A;  3DNG A;  2RJP A;  3Q2H A;  3L0T A;  3G5C A;  2MZE A;  3LE9 A;  1PWU A;  2Y6C A;  4ON1 A;  5D1U A;  1JAQ A;  3TVC A;  4PKV A;  1SAT A;  4G0D A;  2WO8 A;  1XFZ A;  1OS9 A;  1K7G A;  1S4B P;  3NX7 A;  1KAP P;  1MMQ A;  1XFY A;  5BOT A;  4GWM A;  3OHL A;  1Y0V A;  5D3C A;  2K9C A;  1ZS0 A;  2OW1 A;  4PKW A;  1BSW A;  1KUG A;  1GE6 A;  2DW1 A;  2OVX A;  3V96 B;  4H76 A;  2A8H A;  1DTH A;  1G4K A;  4XBH A;  1FLS A;  5B5P A;  2FV9 A;  1WNI A;  2YB9 A;  2SRT A;  2W13 A;  3F1A A;  1C7K A;  1OM8 A;  3DL1 A;  1JAP A;  3HYG A;  1OM7 A;  1UEA A;  1XFU A;  1SU3 A;  1UTT A;  3N2U A;  4DV8 A;  3KME A;  1GO7 P;  1SLN A;  3LJT A;  3K7L A;  1QIB A;  1FBL A;  4WZV A;  1GXD A;  1KUH A;  1IAB A;  2AIG P;  3DPF A;  1KUF A;  4JPA A;  4JP4 A;  1C8T A;  1R1H A;  2O3E A;  1DMT A;  2TCL A;  3LEA A;  1YCM A;  3I7I A;  1SLM A;  3DPE A;  3ZVS A;  2L0R A;  5BOY A;  4QKZ A;  4GR3 A;  2KRJ A;  1XFW A;  4ILW D;  3F17 A;  1H71 P;  1HFS A;  1AKL A;  1K7I A;  2J83 A;  2K2G A;  4XM7 A;  1OS2 A;  1ZP5 A;  3AIG A;  1BQO A;  3O2X A;  1G12 A;  1XFV A;  3LIR A;  1JH1 A;  1GKD A;  4DPE A;  1USN A;  4GUY A;  3USN A;  4Q1L A;  3KHI A;  1IAA A;  3GBO A;  1A86 A;  2JNP A;  4IN9 A;  1IAG A;  2I47 A;  3LJG A;  4I03 A;  5D1S A;  5I43 A;  1XUD A;  2DDF A;  4JQG A;  5JMY A;  2OW0 A;  3ZXH A;  1JAO A;  1GKC A;  4AYK A;  2D1N A;  2Z2D A;  2W0D A;  2OY2 A;  3WV2 A;  1UMT A;  2JSD A;  4FVL A;  3RTT A;  1PWW A;  1R1I A;  3LUM A;  1HTD A;  3ZUK A;  4WKI A;  1UMS A;  2OW2 A;  3LIK A;  3HY9 A;  5I2Z A;  3TSK A;  2CKI A;  1CXV A;  1I1I P;  2HU6 A;  4I35 A;  5CZM A;  4G9L A;  2OXW A;  966C A;  3HDB A;  3HY7 A;  1SRP A;  4A7B A;  1G9K A;  1R1J A;  3O64 A;  1PWP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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