3HY9A

Crystal structure of the catalytic domain of adamts-5 in complex with an amino-2-indanol compound
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
sequence length
217
structure length
217
Chain Sequence
SRARQVELLLVADASMARKYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Catalytic Domain of ADAMTS-5
publication title Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 74
structure length 217
sequence length 217
chains with identical sequence B
ec nomenclature ec 3.4.24.-:
pdb deposition date 2009-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01421 Reprolysin Reprolysin (M12B) family zinc metalloprotease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3hy9A00
4PKTA 2WO8A 1EAKA 3LKAA 1QIBA 1WNIA 2KRJA 2USNA 4GWMA 1IABA 1CQRA 2HU6A 1JIWP 5L79A 4IUWA 4H82A 4WKIA 1OMJA 2MLSA 1SRPA 3KECA 5D1UA 1AKLA 3WV2A 4FXQA 1GO8P 2DDFA 1IAGA 1CAQA 3LUNA 3DNGA 5BPAA 3TSKA 1OS9A 3B92A 4WZVA 2WOAA 2X3CA 3P1VA 1ZS0A 1J7NA 3LMCA 5B5OA 3KRYA 3KMCA 3HY7A 5D7WA 5L7FA 1Y0VA 4HMAA 1GE5A 2K9CA 4HX3A 3G5CA 1KUKA 2Y6DA 2OY4A 2Z2DA 1GXDA 4XM6A 1BIWA 2AYKA 3V96B 2ERPA 2OW9A 5CUHA 1G12A 4XBHA 2WO9A 4I35A 4XM8A 1O0TA 1ZTQA 1ROSA 1UTZA 3O64A 1FBLA 5CZMA 2JT6A 1K7GA 1K7IA 3TVCA 1D8MA 1KUFA 1GE6A 1CGLA 1RM8A 4AIGA 1HFSA 4H49A 1CGFA 3HDBA 1XFYA 3WV3A 4PKQA 2PJTA 5I0LA 2OXWA 2OXZA 2XS4A 3OHLA 3Q2GA 2MZHA 2OI0A 1KUHA 1SLMA 1GKDA 3LEAA 4Q1LA 2RJPA 4L19A 3P24A 4PKUA 1OO9A 1UEAA 830CA 1C7KA 5JMYA 1PWVA 3K7LA 2DW1A 2RJQA 1K7QA 4I03A 1UMSA 3HDAP 4ZR5A 1R1HA 2POJA 2X3BA 2OY2A 1BM6A 1A86A 4H2EA 3DL1A 4JPAA 1XFXA 1FM1A 1Z3JA 2MZEA 3G42A 1OM7A 1JKYA 5BOYA 2ERQA 3BA0A 1OM6A 1XURA 1MMQA 3LQ0A 1I1IP 4GWNA 3LK8A 3L0TA 1ASTA 1OS2A 3RTSA 5I3MA 2EROA 2J83A 2L0RA 3AIGA 1AF0A 3LIRA 4GR3A 1USNA 4ILWD 1QJIA 2W13A 4ON1A 1JAPA 2O3EA 3F15A 1IACA 1R54A 4J4MA 2V4BA 3HBVP 2OVXA 4WF6A 3NX7A 4DPEA 4H30A 1SMPA 1BKCA 1YQYA 4GQLA 4AXQA 5B5PA 3LQBA 3SHIA 1JAOA 2JT5A 1I76A 1JANA 4IJOA 4PKWA 1GO7P 1O0QA 3N2UA 1ATLA 3HBUP 3KEJA 1Y93A 3DWBA 1D5JA 2JNPA 4H3XA 1ZVXA 1HFCA 2X3AA 1XFZA 2A8HA 3LJZA 4FVLA 1DTHA 5I4OA 3F16A 2YIGA 3EHYA 1JIZA 1KBCA 3LIKA 5BOTA 1B8YA 2AIGP 1KAPP 4DD8A 4JP4A 5D2BA 1IADA 4GF1A 1PWPA 1SATA 1Y8JA 4A7BA 5D1SA 1HOVA 1QJJA 1AYKA 3L0VA 1CXVA 2JIHA 2OZRA 4L6TA 5D3CA 2W0DA 1R1IA 3EWJA 1H71P 1QIAA 2TCLA 3F1AA 2W12A 4G9LA 5I2ZA 1BSWA 1PWWA 3VTGA 2YB9A 4QKZA 2K2GA 3I7IA 3LJGA 2J0TA 4L63A 1MMPA 4IN9A 1HY7A 1CGEA 966CA 1XUCA 3AYUA 3MA2A 2O36A 4XM7A 2QPJA 3KWVC 3GBOA 4GUYA 3ZXHA 4GR8A 3U1RA 1XFVA 1R55A 3TT4A 3B2ZA 3B8ZA 2OXUA 1A85A 1BKCI 4R3VA 1MNCA 2OVZA 5I12A 1C8TA 1BKCE 1Q3AA 2CKIA 2DW2A 1YCMA 4FU4A 1HTDA 3F18A 2SRTA 3Q2HA 1C3IA 3KEKA 2W14A 1G05A 1XUDA 3CKIA 2X7MA 3WV1A 3LJTA 4G0DA 4JA1A 1KUIA 1MMBA 4CTHA 1IAEA 2XS3A 4XCTA 3HY9A 1G9KA 2E2DA 3UVCA 4JQGA 1OM8A 2DDYA 3USNA 2CLTA 3F19A 3K7NA 2D1NA 1SLNA 1BZSA 1EUBA 3OHOA 2OW2A 2FV5A 4GR0A 2I47A 3EDZA 1QICA 3O2XA 3I7GA 2D1OA 3DPEA 4JIJA 4PKSA 4H84A 3LGPA 3EHXA 3F17A 1JH1A 1BUVM 1SU3A 4H76A 2DW0A 3TS4A 1D7XA 1XFWA 3LUMA 1EB6A 3ZUKA 1QUAA 1BQQM 1PWUA 5CXAA 1I73A 4DF9A 1G49A 2JSDA 2W15A 3DSLA 1CK7A 2MZIA 4AUOA 4H1QA 4PKRA 1ZXVA 1JJ9A 3N2VA 4AYKA 2MLRA 3HB2P 2OW0A 3KHIA 1G4KA 1ZXCA 456CA 1BUDA 1GE7A 5LABA 3ZVSA 1KUGA 3AYKA 4WKEA 3LILA 1GKCA 1ZP5A 2E3XA 1JAQA 1FLSA 1YOUA 3EDIA 3LE9A 3KMEA 1XFUA 3RTTA 1MMRA 4PKVA 4DV8A 2Y6CA 1S4BP 4FXYP 1HV5A 4A3WA 1CIZA 1YP1A 3VI1A 3EDGA 1B3DA 1IAAA 3ELMA 1L6JA 1D8FA 1PWQA 4WK7A 1BQOA 5D1TA 2N8RA 3E8RA 1DMTA 2FV9A 5H8XA 1UMTA 1UTTA 4EFSA 1JK3A 3HYGA 5I43A 1RMZA 1R1JA 1ND1A 3EDHA 2OW1A 3DPFA
chains in the Genus database with same CATH superfamily
4PKTA 2WO8A 1EAKA 3LKAA 1QIBA 1WNIA 2KRJA 2USNA 4GWMA 1IABA 1CQRA 2HU6A 1JIWP 5L79A 4IUWA 4H82A 4WKIA 1OMJA 2MLSA 1SRPA 3KECA 5D1UA 1AKLA 3WV2A 4FXQA 1GO8P 2DDFA 1IAGA 1CAQA 3LUNA 3DNGA 5BPAA 3TSKA 1OS9A 3B92A 4WZVA 2WOAA 2X3CA 3P1VA 1ZS0A 1J7NA 3LMCA 5B5OA 3KRYA 3KMCA 3HY7A 5D7WA 5L7FA 1Y0VA 4HMAA 1GE5A 2K9CA 4HX3A 3G5CA 1KUKA 2Y6DA 2OY4A 2Z2DA 1GXDA 4XM6A 1BIWA 3DTEA 2AYKA 3V96B 2ERPA 2OW9A 5CUHA 1G12A 4XBHA 2WO9A 4I35A 4XM8A 1O0TA 1ZTQA 1ROSA 1UTZA 3O64A 1FBLA 5CZMA 2JT6A 1K7GA 1K7IA 3TVCA 1D8MA 1KUFA 1GE6A 1CGLA 1RM8A 4AIGA 1HFSA 4H49A 1CGFA 3HDBA 1XFYA 3WV3A 4PKQA 2PJTA 5I0LA 2OXWA 2OXZA 2XS4A 3OHLA 3Q2GA 2YUFA 2MZHA 2OI0A 1KUHA 1SLMA 1GKDA 3LEAA 4Q1LA 2RJPA 4L19A 3P24A 4PKUA 1OO9A 1UEAA 830CA 1C7KA 5JMYA 1PWVA 3K7LA 2DW1A 2RJQA 1K7QA 4I03A 1UMSA 3HDAP 4ZR5A 1R1HA 2POJA 2X3BA 2OY2A 1BM6A 1A86A 4H2EA 3DL1A 4JPAA 1XFXA 1FM1A 1Z3JA 2MZEA 3G42A 1OM7A 1JKYA 5BOYA 2ERQA 3BA0A 1OM6A 1XURA 1MMQA 3LQ0A 1I1IP 4GWNA 3LK8A 3L0TA 1ASTA 1OS2A 3RTSA 5I3MA 2EROA 2J83A 2L0RA 3AIGA 1AF0A 3LIRA 4GR3A 1USNA 4ILWD 1QJIA 2W13A 4ON1A 1JAPA 2O3EA 3F15A 1IACA 1R54A 4J4MA 2V4BA 3HBVP 2OVXA 1XM5A 4WF6A 3NX7A 4DPEA 4H30A 1SMPA 1BKCA 1YQYA 4GQLA 3DTKA 5B5PA 4AXQA 3LQBA 3SHIA 1JAOA 2JT5A 1I76A 1JANA 4IJOA 4PKWA 1GO7P 1O0QA 3N2UA 1ATLA 3HBUP 3KEJA 1Y93A 3DWBA 1D5JA 2JNPA 4H3XA 1ZVXA 1HFCA 2X3AA 1XFZA 2A8HA 3LJZA 4FVLA 1DTHA 5I4OA 3F16A 2YIGA 3EHYA 1JIZA 1KBCA 3LIKA 5BOTA 1B8YA 2AIGP 1KAPP 4DD8A 4JP4A 5D2BA 1IADA 4GF1A 1PWPA 1SATA 1Y8JA 4A7BA 5D1SA 1HOVA 1QJJA 1AYKA 3L0VA 1CXVA 2JIHA 2OZRA 4L6TA 5D3CA 2W0DA 1R1IA 3EWJA 1H71P 1QIAA 2TCLA 3F1AA 2W12A 4G9LA 5I2ZA 1BSWA 1PWWA 3VTGA 2YB9A 4QKZA 2K2GA 3I7IA 3LJGA 2J0TA 4L7AA 4L63A 1MMPA 4IN9A 1HY7A 1CGEA 966CA 1XUCA 3AYUA 3MA2A 2O36A 4XM7A 2QPJA 3KWVC 3GBOA 4GUYA 3ZXHA 4GR8A 3U1RA 1XFVA 1R55A 3TT4A 3B2ZA 3B8ZA 2OXUA 1A85A 1BKCI 4R3VA 1MNCA 2OVZA 5I12A 1C8TA 1BKCE 1Q3AA 2CKIA 2DW2A 1YCMA 4FU4A 1HTDA 3F18A 2SRTA 3Q2HA 1XAXA 1C3IA 3KEKA 2W14A 1G05A 1XUDA 3CKIA 2X7MA 3WV1A 3LJTA 4G0DA 4JA1A 1KUIA 1MMBA 4CTHA 1IAEA 2XS3A 4XCTA 3HY9A 1G9KA 2E2DA 3UVCA 4JQGA 1OM8A 2DDYA 3USNA 2CLTA 3F19A 3K7NA 2D1NA 1SLNA 1BZSA 1EUBA 3OHOA 2OW2A 2FV5A 4GR0A 1TVIA 2I47A 3EDZA 1QICA 3O2XA 3I7GA 2D1OA 3DPEA 4JIJA 4PKSA 4H84A 3LGPA 1OZ9A 3EHXA 3F17A 1JH1A 1BUVM 1SU3A 4H76A 2DW0A 3TS4A 1D7XA 1XFWA 3DTIA 3LUMA 1EB6A 3ZUKA 1QUAA 1BQQM 1PWUA 5CXAA 1I73A 4DF9A 1G49A 2JSDA 2W15A 3DSLA 1CK7A 2MZIA 4AUOA 4H1QA 4PKRA 1ZXVA 1JJ9A 3N2VA 4AYKA 2MLRA 3HB2P 2OW0A 3KHIA 1G4KA 1ZXCA 456CA 1BUDA 1GE7A 5LABA 3ZVSA 1KUGA 3AYKA 4WKEA 3LILA 1GKCA 1ZP5A 2E3XA 1JAQA 1FLSA 1YOUA 3EDIA 3LE9A 3KMEA 1XFUA 3RTTA 1MMRA 4PKVA 4DV8A 2Y6CA 1S4BP 4FXYP 1HV5A 4A3WA 1CIZA 1YP1A 3VI1A 3EDGA 1B3DA 1IAAA 3ELMA 1L6JA 1D8FA 1PWQA 4WK7A 1BQOA 5D1TA 2N8RA 3E8RA 1DMTA 2FV9A 5H8XA 1UMTA 1UTTA 4EFSA 1JK3A 3HYGA 5I43A 1RMZA 1R1JA 1ND1A 3EDHA 2OW1A 3DPFA
chains in the Genus database with same CATH topology
4PKTA 2WO8A 1EAKA 3LKAA 1QIBA 1WNIA 2KRJA 2USNA 4GWMA 1IABA 1CQRA 2HU6A 1JIWP 5L79A 4IUWA 4H82A 4WKIA 1OMJA 2MLSA 1SRPA 3KECA 5D1UA 1AKLA 3WV2A 4FXQA 1GO8P 2DDFA 1IAGA 1CAQA 3LUNA 3DNGA 5BPAA 3TSKA 1OS9A 3B92A 4WZVA 2WOAA 2X3CA 3P1VA 1ZS0A 1J7NA 3LMCA 5B5OA 3KRYA 3KMCA 3HY7A 5D7WA 5L7FA 1Y0VA 4HMAA 1GE5A 2K9CA 4HX3A 3G5CA 1KUKA 2Y6DA 2OY4A 2Z2DA 1GXDA 4XM6A 1BIWA 3DTEA 2AYKA 3V96B 2ERPA 2OW9A 5CUHA 1G12A 4XBHA 2WO9A 4I35A 4XM8A 1O0TA 1ZTQA 1ROSA 1UTZA 3O64A 1FBLA 5CZMA 2JT6A 1K7GA 1K7IA 3TVCA 1D8MA 1KUFA 1GE6A 1CGLA 1RM8A 4AIGA 1HFSA 4H49A 1CGFA 3HDBA 1XFYA 3WV3A 4PKQA 2PJTA 5I0LA 2OXWA 2OXZA 2XS4A 3OHLA 3Q2GA 2YUFA 2MZHA 2OI0A 1KUHA 1SLMA 1GKDA 3LEAA 4Q1LA 2RJPA 4L19A 3P24A 4PKUA 1OO9A 1UEAA 830CA 1C7KA 5JMYA 1PWVA 3K7LA 2DW1A 2RJQA 1K7QA 4I03A 1UMSA 3HDAP 4ZR5A 1R1HA 2POJA 2X3BA 2OY2A 1BM6A 1A86A 4H2EA 3DL1A 4JPAA 1XFXA 1FM1A 1Z3JA 2MZEA 3G42A 1OM7A 1JKYA 5BOYA 2ERQA 3BA0A 1OM6A 1XURA 1MMQA 3LQ0A 1I1IP 4GWNA 3LK8A 3L0TA 1ASTA 1OS2A 3RTSA 5I3MA 2EROA 2J83A 2L0RA 3AIGA 1AF0A 3LIRA 4GR3A 1USNA 4ILWD 1QJIA 2W13A 4ON1A 1JAPA 2O3EA 3F15A 1IACA 1R54A 4J4MA 2V4BA 3HBVP 2OVXA 4WF6A 3NX7A 4DPEA 4H30A 1SMPA 1BKCA 1YQYA 4GQLA 3DTKA 5B5PA 4AXQA 3LQBA 3SHIA 1JAOA 2JT5A 1I76A 1JANA 4IJOA 4PKWA 1GO7P 1O0QA 3N2UA 1ATLA 3HBUP 3KEJA 1Y93A 3DWBA 1D5JA 2JNPA 4H3XA 1ZVXA 1HFCA 2X3AA 1XFZA 2A8HA 3LJZA 4FVLA 1DTHA 5I4OA 3F16A 2YIGA 3EHYA 1JIZA 1KBCA 3LIKA 5BOTA 1B8YA 2AIGP 1KAPP 4DD8A 4JP4A 5D2BA 1IADA 4GF1A 1PWPA 1SATA 1Y8JA 4A7BA 5D1SA 1HOVA 1QJJA 1AYKA 3L0VA 1CXVA 2JIHA 2OZRA 4L6TA 5D3CA 2W0DA 1R1IA 3EWJA 1H71P 1QIAA 2TCLA 3F1AA 2W12A 4G9LA 5I2ZA 1BSWA 1PWWA 3VTGA 2YB9A 4QKZA 2K2GA 3I7IA 3LJGA 2J0TA 4L7AA 4L63A 1MMPA 4IN9A 1HY7A 1CGEA 966CA 1XUCA 3AYUA 3MA2A 2O36A 4XM7A 2QPJA 3KWVC 3GBOA 4GUYA 3ZXHA 4GR8A 3U1RA 1XFVA 1R55A 3TT4A 3B2ZA 3B8ZA 2OXUA 1A85A 1BKCI 4R3VA 1MNCA 2OVZA 5I12A 1C8TA 1BKCE 1Q3AA 2CKIA 2DW2A 1YCMA 4FU4A 1HTDA 3F18A 2SRTA 3Q2HA 1C3IA 3KEKA 2W14A 1G05A 1XUDA 3CKIA 2X7MA 3WV1A 3LJTA 4G0DA 4JA1A 1KUIA 1MMBA 4CTHA 1IAEA 2XS3A 4XCTA 3HY9A 1G9KA 2E2DA 3UVCA 4JQGA 1OM8A 2DDYA 3USNA 2CLTA 3F19A 3K7NA 2D1NA 1SLNA 1BZSA 1EUBA 3OHOA 2OW2A 2FV5A 4GR0A 2I47A 3EDZA 1QICA 3O2XA 3I7GA 2D1OA 3DPEA 4JIJA 4PKSA 4H84A 3LGPA 3EHXA 3F17A 1JH1A 1BUVM 1SU3A 4H76A 2DW0A 3TS4A 1D7XA 1XFWA 3DTIA 3LUMA 1EB6A 3ZUKA 1QUAA 1BQQM 1PWUA 5CXAA 1I73A 4DF9A 1G49A 2JSDA 2W15A 3DSLA 1CK7A 2MZIA 4AUOA 4H1QA 4PKRA 1ZXVA 1JJ9A 3N2VA 4AYKA 2MLRA 3HB2P 2OW0A 3KHIA 1G4KA 1ZXCA 456CA 1BUDA 1GE7A 5LABA 3ZVSA 1KUGA 3AYKA 4WKEA 3LILA 1GKCA 1ZP5A 2E3XA 1JAQA 1FLSA 1YOUA 3EDIA 3LE9A 3KMEA 1XFUA 3RTTA 1MMRA 4PKVA 4DV8A 2Y6CA 1S4BP 4FXYP 1HV5A 4A3WA 1CIZA 1YP1A 3VI1A 3EDGA 1B3DA 1IAAA 3ELMA 1L6JA 1D8FA 1PWQA 4WK7A 1BQOA 5D1TA 2N8RA 3E8RA 1DMTA 2FV9A 5H8XA 1UMTA 1UTTA 4EFSA 1JK3A 3HYGA 5I43A 1RMZA 1R1JA 1ND1A 3EDHA 2OW1A 3DPFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4PKT A;  2WO8 A;  1EAK A;  3LKA A;  1QIB A;  1WNI A;  2KRJ A;  2USN A;  4GWM A;  1IAB A;  1CQR A;  2HU6 A;  1JIW P;  5L79 A;  4IUW A;  4H82 A;  4WKI A;  1OMJ A;  2MLS A;  1SRP A;  3KEC A;  5D1U A;  1AKL A;  3WV2 A;  4FXQ A;  1GO8 P;  2DDF A;  1IAG A;  1CAQ A;  3LUN A;  3DNG A;  5BPA A;  3TSK A;  1OS9 A;  3B92 A;  4WZV A;  2WOA A;  2X3C A;  3P1V A;  1ZS0 A;  1J7N A;  3LMC A;  5B5O A;  3KRY A;  3KMC A;  3HY7 A;  5D7W A;  5L7F A;  1Y0V A;  4HMA A;  1GE5 A;  2K9C A;  4HX3 A;  3G5C A;  1KUK A;  2Y6D A;  2OY4 A;  2Z2D A;  1GXD A;  4XM6 A;  1BIW A;  2AYK A;  3V96 B;  2ERP A;  2OW9 A;  5CUH A;  1G12 A;  4XBH A;  2WO9 A;  4I35 A;  4XM8 A;  1O0T A;  1ZTQ A;  1ROS A;  1UTZ A;  3O64 A;  1FBL A;  5CZM A;  2JT6 A;  1K7G A;  1K7I A;  3TVC A;  1D8M A;  1KUF A;  1GE6 A;  1CGL A;  1RM8 A;  4AIG A;  1HFS A;  4H49 A;  1CGF A;  3HDB A;  1XFY A;  3WV3 A;  4PKQ A;  2PJT A;  5I0L A;  2OXW A;  2OXZ A;  2XS4 A;  3OHL A;  3Q2G A;  2MZH A;  2OI0 A;  1KUH A;  1SLM A;  1GKD A;  3LEA A;  4Q1L A;  2RJP A;  4L19 A;  3P24 A;  4PKU A;  1OO9 A;  1UEA A;  830C A;  1C7K A;  5JMY A;  1PWV A;  3K7L A;  2DW1 A;  2RJQ A;  1K7Q A;  4I03 A;  1UMS A;  3HDA P;  4ZR5 A;  1R1H A;  2POJ A;  2X3B A;  2OY2 A;  1BM6 A;  1A86 A;  4H2E A;  3DL1 A;  4JPA A;  1XFX A;  1FM1 A;  1Z3J A;  2MZE A;  3G42 A;  1OM7 A;  1JKY A;  5BOY A;  2ERQ A;  3BA0 A;  1OM6 A;  1XUR A;  1MMQ A;  3LQ0 A;  1I1I P;  4GWN A;  3LK8 A;  3L0T A;  1AST A;  1OS2 A;  3RTS A;  5I3M A;  2ERO A;  2J83 A;  2L0R A;  3AIG A;  1AF0 A;  3LIR A;  4GR3 A;  1USN A;  4ILW D;  1QJI A;  2W13 A;  4ON1 A;  1JAP A;  2O3E A;  3F15 A;  1IAC A;  1R54 A;  4J4M A;  2V4B A;  3HBV P;  2OVX A;  4WF6 A;  3NX7 A;  4DPE A;  4H30 A;  1SMP A;  1BKC A;  1YQY A;  4GQL A;  4AXQ A;  5B5P A;  3LQB A;  3SHI A;  1JAO A;  2JT5 A;  1I76 A;  1JAN A;  4IJO A;  4PKW A;  1GO7 P;  1O0Q A;  3N2U A;  1ATL A;  3HBU P;  3KEJ A;  1Y93 A;  3DWB A;  1D5J A;  2JNP A;  4H3X A;  1ZVX A;  1HFC A;  2X3A A;  1XFZ A;  2A8H A;  3LJZ A;  4FVL A;  1DTH A;  5I4O A;  3F16 A;  2YIG A;  3EHY A;  1JIZ A;  1KBC A;  3LIK A;  5BOT A;  1B8Y A;  2AIG P;  1KAP P;  4DD8 A;  4JP4 A;  5D2B A;  1IAD A;  4GF1 A;  1PWP A;  1SAT A;  1Y8J A;  4A7B A;  5D1S A;  1HOV A;  1QJJ A;  1AYK A;  3L0V A;  1CXV A;  2JIH A;  2OZR A;  4L6T A;  5D3C A;  2W0D A;  1R1I A;  3EWJ A;  1H71 P;  1QIA A;  2TCL A;  3F1A A;  2W12 A;  4G9L A;  5I2Z A;  1BSW A;  1PWW A;  3VTG A;  2YB9 A;  4QKZ A;  2K2G A;  3I7I A;  3LJG A;  2J0T A;  4L63 A;  1MMP A;  4IN9 A;  1HY7 A;  1CGE A;  966C A;  1XUC A;  3AYU A;  3MA2 A;  2O36 A;  4XM7 A;  2QPJ A;  3KWV C;  3GBO A;  4GUY A;  3ZXH A;  4GR8 A;  3U1R A;  1XFV A;  1R55 A;  3TT4 A;  3B2Z A;  3B8Z A;  2OXU A;  1A85 A;  1BKC I;  4R3V A;  1MNC A;  2OVZ A;  5I12 A;  1C8T A;  1BKC E;  1Q3A A;  2CKI A;  2DW2 A;  1YCM A;  4FU4 A;  1HTD A;  3F18 A;  2SRT A;  3Q2H A;  1C3I A;  3KEK A;  2W14 A;  1G05 A;  1XUD A;  3CKI A;  2X7M A;  3WV1 A;  3LJT A;  4G0D A;  4JA1 A;  1KUI A;  1MMB A;  4CTH A;  1IAE A;  2XS3 A;  4XCT A;  3HY9 A;  1G9K A;  2E2D A;  3UVC A;  4JQG A;  1OM8 A;  2DDY A;  3USN A;  2CLT A;  3F19 A;  3K7N A;  2D1N A;  1SLN A;  1BZS A;  1EUB A;  3OHO A;  2OW2 A;  2FV5 A;  4GR0 A;  2I47 A;  3EDZ A;  1QIC A;  3O2X A;  3I7G A;  2D1O A;  3DPE A;  4JIJ A;  4PKS A;  4H84 A;  3LGP A;  3EHX A;  3F17 A;  1JH1 A;  1BUV M;  1SU3 A;  4H76 A;  2DW0 A;  3TS4 A;  1D7X A;  1XFW A;  3LUM A;  1EB6 A;  3ZUK A;  1QUA A;  1BQQ M;  1PWU A;  5CXA A;  1I73 A;  4DF9 A;  1G49 A;  2JSD A;  2W15 A;  3DSL A;  1CK7 A;  2MZI A;  4AUO A;  4H1Q A;  4PKR A;  1ZXV A;  1JJ9 A;  3N2V A;  4AYK A;  2MLR A;  3HB2 P;  2OW0 A;  3KHI A;  1G4K A;  1ZXC A;  456C A;  1BUD A;  1GE7 A;  5LAB A;  3ZVS A;  1KUG A;  3AYK A;  4WKE A;  3LIL A;  1GKC A;  1ZP5 A;  2E3X A;  1JAQ A;  1FLS A;  1YOU A;  3EDI A;  3LE9 A;  3KME A;  1XFU A;  3RTT A;  1MMR A;  4PKV A;  4DV8 A;  2Y6C A;  1S4B P;  4FXY P;  1HV5 A;  4A3W A;  1CIZ A;  1YP1 A;  3VI1 A;  3EDG A;  1B3D A;  1IAA A;  3ELM A;  1L6J A;  1D8F A;  1PWQ A;  4WK7 A;  1BQO A;  5D1T A;  2N8R A;  3E8R A;  1DMT A;  2FV9 A;  5H8X A;  1UMT A;  1UTT A;  4EFS A;  1JK3 A;  3HYG A;  5I43 A;  1RMZ A;  1R1J A;  1ND1 A;  3EDH A;  2OW1 A;  3DPF A; 
#chains in the Genus database with same CATH topology
 4PKT A;  2WO8 A;  1EAK A;  3LKA A;  1QIB A;  1WNI A;  2KRJ A;  2USN A;  4GWM A;  1IAB A;  1CQR A;  2HU6 A;  1JIW P;  5L79 A;  4IUW A;  4H82 A;  4WKI A;  1OMJ A;  2MLS A;  1SRP A;  3KEC A;  5D1U A;  1AKL A;  3WV2 A;  4FXQ A;  1GO8 P;  2DDF A;  1IAG A;  1CAQ A;  3LUN A;  3DNG A;  5BPA A;  3TSK A;  1OS9 A;  3B92 A;  4WZV A;  2WOA A;  2X3C A;  3P1V A;  1ZS0 A;  1J7N A;  3LMC A;  5B5O A;  3KRY A;  3KMC A;  3HY7 A;  5D7W A;  5L7F A;  1Y0V A;  4HMA A;  1GE5 A;  2K9C A;  4HX3 A;  3G5C A;  1KUK A;  2Y6D A;  2OY4 A;  2Z2D A;  1GXD A;  4XM6 A;  1BIW A;  3DTE A;  2AYK A;  3V96 B;  2ERP A;  2OW9 A;  5CUH A;  1G12 A;  4XBH A;  2WO9 A;  4I35 A;  4XM8 A;  1O0T A;  1ZTQ A;  1ROS A;  1UTZ A;  3O64 A;  1FBL A;  5CZM A;  2JT6 A;  1K7G A;  1K7I A;  3TVC A;  1D8M A;  1KUF A;  1GE6 A;  1CGL A;  1RM8 A;  4AIG A;  1HFS A;  4H49 A;  1CGF A;  3HDB A;  1XFY A;  3WV3 A;  4PKQ A;  2PJT A;  5I0L A;  2OXW A;  2OXZ A;  2XS4 A;  3OHL A;  3Q2G A;  2YUF A;  2MZH A;  2OI0 A;  1KUH A;  1SLM A;  1GKD A;  3LEA A;  4Q1L A;  2RJP A;  4L19 A;  3P24 A;  4PKU A;  1OO9 A;  1UEA A;  830C A;  1C7K A;  5JMY A;  1PWV A;  3K7L A;  2DW1 A;  2RJQ A;  1K7Q A;  4I03 A;  1UMS A;  3HDA P;  4ZR5 A;  1R1H A;  2POJ A;  2X3B A;  2OY2 A;  1BM6 A;  1A86 A;  4H2E A;  3DL1 A;  4JPA A;  1XFX A;  1FM1 A;  1Z3J A;  2MZE A;  3G42 A;  1OM7 A;  1JKY A;  5BOY A;  2ERQ A;  3BA0 A;  1OM6 A;  1XUR A;  1MMQ A;  3LQ0 A;  1I1I P;  4GWN A;  3LK8 A;  3L0T A;  1AST A;  1OS2 A;  3RTS A;  5I3M A;  2ERO A;  2J83 A;  2L0R A;  3AIG A;  1AF0 A;  3LIR A;  4GR3 A;  1USN A;  4ILW D;  1QJI A;  2W13 A;  4ON1 A;  1JAP A;  2O3E A;  3F15 A;  1IAC A;  1R54 A;  4J4M A;  2V4B A;  3HBV P;  2OVX A;  1XM5 A;  4WF6 A;  3NX7 A;  4DPE A;  4H30 A;  1SMP A;  1BKC A;  1YQY A;  4GQL A;  3DTK A;  5B5P A;  4AXQ A;  3LQB A;  3SHI A;  1JAO A;  2JT5 A;  1I76 A;  1JAN A;  4IJO A;  4PKW A;  1GO7 P;  1O0Q A;  3N2U A;  1ATL A;  3HBU P;  3KEJ A;  1Y93 A;  3DWB A;  1D5J A;  2JNP A;  4H3X A;  1ZVX A;  1HFC A;  2X3A A;  1XFZ A;  2A8H A;  3LJZ A;  4FVL A;  1DTH A;  5I4O A;  3F16 A;  2YIG A;  3EHY A;  1JIZ A;  1KBC A;  3LIK A;  5BOT A;  1B8Y A;  2AIG P;  1KAP P;  4DD8 A;  4JP4 A;  5D2B A;  1IAD A;  4GF1 A;  1PWP A;  1SAT A;  1Y8J A;  4A7B A;  5D1S A;  1HOV A;  1QJJ A;  1AYK A;  3L0V A;  1CXV A;  2JIH A;  2OZR A;  4L6T A;  5D3C A;  2W0D A;  1R1I A;  3EWJ A;  1H71 P;  1QIA A;  2TCL A;  3F1A A;  2W12 A;  4G9L A;  5I2Z A;  1BSW A;  1PWW A;  3VTG A;  2YB9 A;  4QKZ A;  2K2G A;  3I7I A;  3LJG A;  2J0T A;  4L7A A;  4L63 A;  1MMP A;  4IN9 A;  1HY7 A;  1CGE A;  966C A;  1XUC A;  3AYU A;  3MA2 A;  2O36 A;  4XM7 A;  2QPJ A;  3KWV C;  3GBO A;  4GUY A;  3ZXH A;  4GR8 A;  3U1R A;  1XFV A;  1R55 A;  3TT4 A;  3B2Z A;  3B8Z A;  2OXU A;  1A85 A;  1BKC I;  4R3V A;  1MNC A;  2OVZ A;  5I12 A;  1C8T A;  1BKC E;  1Q3A A;  2CKI A;  2DW2 A;  1YCM A;  4FU4 A;  1HTD A;  3F18 A;  2SRT A;  3Q2H A;  1XAX A;  1C3I A;  3KEK A;  2W14 A;  1G05 A;  1XUD A;  3CKI A;  2X7M A;  3WV1 A;  3LJT A;  4G0D A;  4JA1 A;  1KUI A;  1MMB A;  4CTH A;  1IAE A;  2XS3 A;  4XCT A;  3HY9 A;  1G9K A;  2E2D A;  3UVC A;  4JQG A;  1OM8 A;  2DDY A;  3USN A;  2CLT A;  3F19 A;  3K7N A;  2D1N A;  1SLN A;  1BZS A;  1EUB A;  3OHO A;  2OW2 A;  2FV5 A;  4GR0 A;  1TVI A;  2I47 A;  3EDZ A;  1QIC A;  3O2X A;  3I7G A;  2D1O A;  3DPE A;  4JIJ A;  4PKS A;  4H84 A;  3LGP A;  1OZ9 A;  3EHX A;  3F17 A;  1JH1 A;  1BUV M;  1SU3 A;  4H76 A;  2DW0 A;  3TS4 A;  1D7X A;  1XFW A;  3DTI A;  3LUM A;  1EB6 A;  3ZUK A;  1QUA A;  1BQQ M;  1PWU A;  5CXA A;  1I73 A;  4DF9 A;  1G49 A;  2JSD A;  2W15 A;  3DSL A;  1CK7 A;  2MZI A;  4AUO A;  4H1Q A;  4PKR A;  1ZXV A;  1JJ9 A;  3N2V A;  4AYK A;  2MLR A;  3HB2 P;  2OW0 A;  3KHI A;  1G4K A;  1ZXC A;  456C A;  1BUD A;  1GE7 A;  5LAB A;  3ZVS A;  1KUG A;  3AYK A;  4WKE A;  3LIL A;  1GKC A;  1ZP5 A;  2E3X A;  1JAQ A;  1FLS A;  1YOU A;  3EDI A;  3LE9 A;  3KME A;  1XFU A;  3RTT A;  1MMR A;  4PKV A;  4DV8 A;  2Y6C A;  1S4B P;  4FXY P;  1HV5 A;  4A3W A;  1CIZ A;  1YP1 A;  3VI1 A;  3EDG A;  1B3D A;  1IAA A;  3ELM A;  1L6J A;  1D8F A;  1PWQ A;  4WK7 A;  1BQO A;  5D1T A;  2N8R A;  3E8R A;  1DMT A;  2FV9 A;  5H8X A;  1UMT A;  1UTT A;  4EFS A;  1JK3 A;  3HYG A;  5I43 A;  1RMZ A;  1R1J A;  1ND1 A;  3EDH A;  2OW1 A;  3DPF A; 
#chains in the Genus database with same CATH homology
 4PKT A;  2WO8 A;  1EAK A;  3LKA A;  1QIB A;  1WNI A;  2KRJ A;  2USN A;  4GWM A;  1IAB A;  1CQR A;  2HU6 A;  1JIW P;  5L79 A;  4IUW A;  4H82 A;  4WKI A;  1OMJ A;  2MLS A;  1SRP A;  3KEC A;  5D1U A;  1AKL A;  3WV2 A;  4FXQ A;  1GO8 P;  2DDF A;  1IAG A;  1CAQ A;  3LUN A;  3DNG A;  5BPA A;  3TSK A;  1OS9 A;  3B92 A;  4WZV A;  2WOA A;  2X3C A;  3P1V A;  1ZS0 A;  1J7N A;  3LMC A;  5B5O A;  3KRY A;  3KMC A;  3HY7 A;  5D7W A;  5L7F A;  1Y0V A;  4HMA A;  1GE5 A;  2K9C A;  4HX3 A;  3G5C A;  1KUK A;  2Y6D A;  2OY4 A;  2Z2D A;  1GXD A;  4XM6 A;  1BIW A;  3DTE A;  2AYK A;  3V96 B;  2ERP A;  2OW9 A;  5CUH A;  1G12 A;  4XBH A;  2WO9 A;  4I35 A;  4XM8 A;  1O0T A;  1ZTQ A;  1ROS A;  1UTZ A;  3O64 A;  1FBL A;  5CZM A;  2JT6 A;  1K7G A;  1K7I A;  3TVC A;  1D8M A;  1KUF A;  1GE6 A;  1CGL A;  1RM8 A;  4AIG A;  1HFS A;  4H49 A;  1CGF A;  3HDB A;  1XFY A;  3WV3 A;  4PKQ A;  2PJT A;  5I0L A;  2OXW A;  2OXZ A;  2XS4 A;  3OHL A;  3Q2G A;  2YUF A;  2MZH A;  2OI0 A;  1KUH A;  1SLM A;  1GKD A;  3LEA A;  4Q1L A;  2RJP A;  4L19 A;  3P24 A;  4PKU A;  1OO9 A;  1UEA A;  830C A;  1C7K A;  5JMY A;  1PWV A;  3K7L A;  2DW1 A;  2RJQ A;  1K7Q A;  4I03 A;  1UMS A;  3HDA P;  4ZR5 A;  1R1H A;  2POJ A;  2X3B A;  2OY2 A;  1BM6 A;  1A86 A;  4H2E A;  3DL1 A;  4JPA A;  1XFX A;  1FM1 A;  1Z3J A;  2MZE A;  3G42 A;  1OM7 A;  1JKY A;  5BOY A;  2ERQ A;  3BA0 A;  1OM6 A;  1XUR A;  1MMQ A;  3LQ0 A;  1I1I P;  4GWN A;  3LK8 A;  3L0T A;  1AST A;  1OS2 A;  3RTS A;  5I3M A;  2ERO A;  2J83 A;  2L0R A;  3AIG A;  1AF0 A;  3LIR A;  4GR3 A;  1USN A;  4ILW D;  1QJI A;  2W13 A;  4ON1 A;  1JAP A;  2O3E A;  3F15 A;  1IAC A;  1R54 A;  4J4M A;  2V4B A;  3HBV P;  2OVX A;  4WF6 A;  3NX7 A;  4DPE A;  4H30 A;  1SMP A;  1BKC A;  1YQY A;  4GQL A;  3DTK A;  5B5P A;  4AXQ A;  3LQB A;  3SHI A;  1JAO A;  2JT5 A;  1I76 A;  1JAN A;  4IJO A;  4PKW A;  1GO7 P;  1O0Q A;  3N2U A;  1ATL A;  3HBU P;  3KEJ A;  1Y93 A;  3DWB A;  1D5J A;  2JNP A;  4H3X A;  1ZVX A;  1HFC A;  2X3A A;  1XFZ A;  2A8H A;  3LJZ A;  4FVL A;  1DTH A;  5I4O A;  3F16 A;  2YIG A;  3EHY A;  1JIZ A;  1KBC A;  3LIK A;  5BOT A;  1B8Y A;  2AIG P;  1KAP P;  4DD8 A;  4JP4 A;  5D2B A;  1IAD A;  4GF1 A;  1PWP A;  1SAT A;  1Y8J A;  4A7B A;  5D1S A;  1HOV A;  1QJJ A;  1AYK A;  3L0V A;  1CXV A;  2JIH A;  2OZR A;  4L6T A;  5D3C A;  2W0D A;  1R1I A;  3EWJ A;  1H71 P;  1QIA A;  2TCL A;  3F1A A;  2W12 A;  4G9L A;  5I2Z A;  1BSW A;  1PWW A;  3VTG A;  2YB9 A;  4QKZ A;  2K2G A;  3I7I A;  3LJG A;  2J0T A;  4L7A A;  4L63 A;  1MMP A;  4IN9 A;  1HY7 A;  1CGE A;  966C A;  1XUC A;  3AYU A;  3MA2 A;  2O36 A;  4XM7 A;  2QPJ A;  3KWV C;  3GBO A;  4GUY A;  3ZXH A;  4GR8 A;  3U1R A;  1XFV A;  1R55 A;  3TT4 A;  3B2Z A;  3B8Z A;  2OXU A;  1A85 A;  1BKC I;  4R3V A;  1MNC A;  2OVZ A;  5I12 A;  1C8T A;  1BKC E;  1Q3A A;  2CKI A;  2DW2 A;  1YCM A;  4FU4 A;  1HTD A;  3F18 A;  2SRT A;  3Q2H A;  1C3I A;  3KEK A;  2W14 A;  1G05 A;  1XUD A;  3CKI A;  2X7M A;  3WV1 A;  3LJT A;  4G0D A;  4JA1 A;  1KUI A;  1MMB A;  4CTH A;  1IAE A;  2XS3 A;  4XCT A;  3HY9 A;  1G9K A;  2E2D A;  3UVC A;  4JQG A;  1OM8 A;  2DDY A;  3USN A;  2CLT A;  3F19 A;  3K7N A;  2D1N A;  1SLN A;  1BZS A;  1EUB A;  3OHO A;  2OW2 A;  2FV5 A;  4GR0 A;  2I47 A;  3EDZ A;  1QIC A;  3O2X A;  3I7G A;  2D1O A;  3DPE A;  4JIJ A;  4PKS A;  4H84 A;  3LGP A;  3EHX A;  3F17 A;  1JH1 A;  1BUV M;  1SU3 A;  4H76 A;  2DW0 A;  3TS4 A;  1D7X A;  1XFW A;  3DTI A;  3LUM A;  1EB6 A;  3ZUK A;  1QUA A;  1BQQ M;  1PWU A;  5CXA A;  1I73 A;  4DF9 A;  1G49 A;  2JSD A;  2W15 A;  3DSL A;  1CK7 A;  2MZI A;  4AUO A;  4H1Q A;  4PKR A;  1ZXV A;  1JJ9 A;  3N2V A;  4AYK A;  2MLR A;  3HB2 P;  2OW0 A;  3KHI A;  1G4K A;  1ZXC A;  456C A;  1BUD A;  1GE7 A;  5LAB A;  3ZVS A;  1KUG A;  3AYK A;  4WKE A;  3LIL A;  1GKC A;  1ZP5 A;  2E3X A;  1JAQ A;  1FLS A;  1YOU A;  3EDI A;  3LE9 A;  3KME A;  1XFU A;  3RTT A;  1MMR A;  4PKV A;  4DV8 A;  2Y6C A;  1S4B P;  4FXY P;  1HV5 A;  4A3W A;  1CIZ A;  1YP1 A;  3VI1 A;  3EDG A;  1B3D A;  1IAA A;  3ELM A;  1L6J A;  1D8F A;  1PWQ A;  4WK7 A;  1BQO A;  5D1T A;  2N8R A;  3E8R A;  1DMT A;  2FV9 A;  5H8X A;  1UMT A;  1UTT A;  4EFS A;  1JK3 A;  3HYG A;  5I43 A;  1RMZ A;  1R1J A;  1ND1 A;  3EDH A;  2OW1 A;  3DPF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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