3O64A

Crystal structure of catalytic domain of tace with 2-(2-aminothiazol-4-yl)pyrrolidine-based tartrate diamides
Total Genus 82
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
82
sequence length
258
structure length
252
Chain Sequence
DPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords TACE
publication title 2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors.
pubmed doi rcsb
source organism Homo sapiens
total genus 82
structure length 252
sequence length 258
chains with identical sequence B
ec nomenclature ec 3.4.24.86: ADAM 17 endopeptidase.
pdb deposition date 2010-07-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13688 Reprolysin_5 Metallo-peptidase family M12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3o64A00
4H2EA 4HMAA 1D8FA 3HDAP 2SRTA 3KHIA 3LGPA 1R1IA 1A86A 4H84A 1GXDA 3F1AA 5D7WA 1JAOA 2J83A 3UVCA 1R54A 3WV2A 1K7IA 4JP4A 1YCMA 1BQOA 1GE6A 1HV5A 4PKSA 4R3VA 4PKWA 1IAGA 1AYKA 4PKVA 1YP1A 1QIAA 4WK7A 3AYKA 1XUDA 1QUAA 1OS2A 1DTHA 3LQ0A 1CGLA 4DF9A 1I73A 2X3BA 3OHLA 2WOAA 3EDHA 4AYKA 1Z3JA 2RJPA 1ZTQA 1MMRA 4H76A 2DW1A 1BKCI 3B2ZA 1UTZA 1XURA 1EAKA 2Y6CA 4PKQA 1B3DA 3KMEA 2KRJA 3HB2P 3LKAA 2OW0A 1B8YA 1SMPA 2D1OA 3NX7A 3SHIA 1BZSA 1KBCA 1OM6A 1OMJA 1BKCE 3CKIA 1YOUA 3LK8A 1D7XA 2FV5A 3OHOA 3RTTA 5L79A 1ROSA 1OM7A 3L0TA 1K7QA 4L63A 3E8RA 2JIHA 2JNPA 4DV8A 2W14A 1QIBA 4XM6A 1KUGA 1AKLA 1YQYA 1Y8JA 1D5JA 3DSLA 4AUOA 2W15A 1RM8A 1S4BP 2YIGA 3O64A 3I7IA 2DW0A 3LE9A 1KAPP 4GR8A 2MLSA 3DPEA 1Q3AA 4XM8A 5D1SA 2OZRA 2TCLA 3LMCA 1SATA 4HX3A 3EDGA 4G0DA 3KMCA 1DMTA 3AYUA 1C7KA 1HY7A 1HTDA 2A8HA 2HU6A 1FLSA 4I35A 3B92A 2OW1A 5LABA 1CQRA 4FXYP 4EFSA 1GKCA 3GBOA 5H8XA 3V96B 5B5PA 2PJTA 1HFSA 2K9CA 1R55A 4L19A 4XBHA 3RTSA 5D2BA 1Y0VA 5I4OA 4ON1A 2X3AA 4QKZA 2WO8A 2OY4A 1OS9A 2EROA 1EUBA 1ND1A 3HYGA 4H3XA 1IADA 1CK7A 4FU4A 2USNA 1IACA 4L6TA 2ERQA 2CKIA 3Q2GA 2W13A 1PWWA 1MMBA 4A3WA 3TS4A 1IAEA 1G9KA 1PWVA 1XFVA 3G5CA 1IABA 3USNA 1K7GA 2WO9A 1G12A 3DNGA 1KUHA 1WNIA 1UMTA 5L7FA 3G42A 2W0DA 1CGFA 1JAQA 2O3EA 1GO7P 1RMZA 3KWVC 3TSKA 2K2GA 1L6JA 3L0VA 3AIGA 3WV1A 1ZP5A 1BIWA 3F18A 1GKDA 1XUCA 1XFXA 2DDYA 1QJJA 2MZEA 1ATLA 2QPJA 1OO9A 4FVLA 1R1JA 1BKCA 3K7LA 1JAPA 4J4MA 2FV9A 3EDZA 1JIWP 1GE7A 2X7MA 1BM6A 5CXAA 1OM8A 3N2UA 1UMSA 1FM1A 1XFYA 2POJA 3I7GA 3KEKA 1QJIA 2DDFA 1XFWA 5BPAA 2AIGP 2OW9A 4WF6A 2D1NA 1G49A 1SLNA 5BOYA 1PWQA 3EWJA 2JT6A 3P1VA 1I1IP 3U1RA 3DPFA 4ILWD 1ZS0A 4GWNA 1A85A 1UEAA 2OY2A 3F15A 3HY9A 1SU3A 1JK3A 3TVCA 5CUHA 3KEJA 1CGEA 5I3MA 1J7NA 1BSWA 5D1UA 1PWUA 4PKUA 3BA0A 3F19A 2I47A 1HFCA 4JPAA 1ZVXA 2DW2A 5JMYA 2Y6DA 4IUWA 4H49A 4AXQA 5I43A 2OW2A 2XS4A 4DD8A 3HY7A 3EHYA 1JIZA 1SRPA 2O36A 3MA2A 4FXQA 1EB6A 3B8ZA 1FBLA 1G4KA 3F16A 1GE5A 3LIRA 3LUNA 2E3XA 4PKRA 3ELMA 4JA1A 1MNCA 4WKEA 4XCTA 1CAQA 1G05A 5B5OA 1PWPA 1R1HA 1O0QA 3EHXA 1BUDA 3KRYA 2MZIA 2L0RA 2OVZA 3LJGA 3VI1A 456CA 3HDBA 4IJOA 4JQGA 4GUYA 1QICA 1CIZA 3O2XA 1Y93A 3EDIA 4G9LA 1ASTA 2ERPA 3VTGA 3ZUKA 4GR3A 2E2DA 2CLTA 3F17A 4GR0A 3HBUP 3LUMA 3LJZA 4H30A 2AYKA 1JH1A 1MMQA 3K7NA 4WZVA 4GQLA 4GWMA 2YB9A 1H71P 4GF1A 2MZHA 2X3CA 4DPEA 1IAAA 4PKTA 1JANA 3WV3A 3TT4A 1AF0A 3LJTA 2MLRA 2OI0A 3KECA 2N8RA 4AIGA 4ZR5A 1C3IA 2Z2DA 4Q1LA 1ZXVA 3Q2HA 2OVXA 1KUIA 1XFZA 5I2ZA 5I0LA 1ZXCA 1CXVA 2V4BA 2OXWA 3LILA 1JJ9A 1USNA 2JSDA 2OXUA 1JKYA 4A7BA 3N2VA 3ZXHA 1XFUA 2J0TA 4I03A 3HBVP 1GO8P 4H1QA 1D8MA 5I12A 1KUKA 4CTHA 5BOTA 5D3CA 3P24A 2RJQA 3LQBA 1BQQM 966CA 830CA 4H82A 4JIJA 1C8TA 1I76A 2XS3A 1HOVA 1KUFA 1MMPA 4XM7A 1SLMA 3LIKA 3ZVSA 1BUVM 1O0TA 4IN9A 1UTTA 3LEAA 2OXZA 4WKIA 5D1TA 2W12A 2JT5A 3DWBA 3DL1A 5CZMA
chains in the Genus database with same CATH superfamily
4H2EA 4HMAA 1D8FA 3HDAP 2SRTA 3KHIA 3LGPA 1R1IA 1A86A 4H84A 1GXDA 3F1AA 5D7WA 1JAOA 2J83A 3UVCA 1R54A 3WV2A 1K7IA 4JP4A 1YCMA 1BQOA 1GE6A 1HV5A 4PKSA 4R3VA 4PKWA 1IAGA 1AYKA 4PKVA 1YP1A 1QIAA 4WK7A 3AYKA 1XUDA 1QUAA 1OS2A 1DTHA 3LQ0A 1CGLA 4DF9A 1I73A 2X3BA 3OHLA 1XAXA 2WOAA 3EDHA 4AYKA 1Z3JA 2RJPA 1ZTQA 1MMRA 4H76A 2DW1A 1BKCI 3B2ZA 3DTEA 1UTZA 1XURA 1EAKA 2Y6CA 4PKQA 1B3DA 3KMEA 2KRJA 3HB2P 3LKAA 2OW0A 1B8YA 1SMPA 2D1OA 3NX7A 3SHIA 1BZSA 1KBCA 1OM6A 1OMJA 1BKCE 3CKIA 1YOUA 3LK8A 1D7XA 2FV5A 3OHOA 3RTTA 5L79A 1ROSA 1OM7A 3L0TA 1K7QA 4L63A 3E8RA 4L7AA 2JIHA 2JNPA 4DV8A 2W14A 1QIBA 4XM6A 1KUGA 1AKLA 1YQYA 1Y8JA 1D5JA 3DSLA 4AUOA 2W15A 1RM8A 1S4BP 2YIGA 3O64A 3I7IA 2DW0A 3LE9A 1KAPP 4GR8A 2MLSA 3DPEA 1Q3AA 4XM8A 5D1SA 2OZRA 2TCLA 3LMCA 1SATA 4HX3A 3EDGA 4G0DA 3KMCA 1DMTA 3AYUA 1C7KA 1HY7A 1HTDA 2A8HA 2HU6A 1FLSA 4I35A 3B92A 2OW1A 5LABA 1CQRA 4FXYP 4EFSA 1GKCA 3GBOA 5H8XA 3V96B 5B5PA 2PJTA 1HFSA 2K9CA 1R55A 4L19A 4XBHA 3RTSA 5D2BA 1Y0VA 5I4OA 4ON1A 2X3AA 4QKZA 2WO8A 2OY4A 1OS9A 2EROA 1EUBA 1ND1A 3HYGA 4H3XA 1IADA 1CK7A 4FU4A 2USNA 1IACA 4L6TA 2ERQA 2CKIA 3Q2GA 2W13A 1PWWA 1MMBA 4A3WA 1TVIA 3TS4A 1IAEA 1G9KA 1PWVA 1XFVA 3G5CA 1IABA 3USNA 1K7GA 2WO9A 1G12A 3DNGA 1KUHA 1WNIA 1UMTA 5L7FA 3G42A 2W0DA 1CGFA 1JAQA 2O3EA 1GO7P 1RMZA 3KWVC 3TSKA 2K2GA 1L6JA 3L0VA 3AIGA 3WV1A 1ZP5A 1BIWA 3F18A 1GKDA 1XUCA 1XFXA 2DDYA 1QJJA 2MZEA 1ATLA 2QPJA 1OO9A 4FVLA 1R1JA 1BKCA 3K7LA 1JAPA 4J4MA 2FV9A 3EDZA 1JIWP 1GE7A 2X7MA 1BM6A 5CXAA 1OM8A 3N2UA 1UMSA 1FM1A 1XFYA 2POJA 3I7GA 3KEKA 1QJIA 2DDFA 1XFWA 5BPAA 2AIGP 2OW9A 4WF6A 2D1NA 1G49A 1SLNA 5BOYA 1PWQA 3EWJA 2JT6A 3P1VA 1I1IP 3U1RA 3DPFA 4ILWD 1ZS0A 4GWNA 1A85A 1UEAA 2OY2A 3F15A 3HY9A 1SU3A 1JK3A 3TVCA 5CUHA 3KEJA 1CGEA 5I3MA 1J7NA 1BSWA 5D1UA 1PWUA 4PKUA 3BA0A 3F19A 2I47A 1HFCA 4JPAA 1ZVXA 2DW2A 5JMYA 2Y6DA 4IUWA 4H49A 4AXQA 5I43A 2OW2A 2XS4A 4DD8A 3HY7A 3EHYA 1JIZA 1SRPA 2O36A 3MA2A 4FXQA 1EB6A 3B8ZA 1FBLA 3DTKA 1G4KA 3F16A 1GE5A 3LIRA 3LUNA 2E3XA 4PKRA 3ELMA 4JA1A 1MNCA 4WKEA 4XCTA 1CAQA 1G05A 5B5OA 1PWPA 1R1HA 1O0QA 3EHXA 1BUDA 3KRYA 2MZIA 2L0RA 2OVZA 3LJGA 3VI1A 456CA 3HDBA 4IJOA 4JQGA 4GUYA 1QICA 1CIZA 3O2XA 1Y93A 3EDIA 4G9LA 1ASTA 2ERPA 3VTGA 3ZUKA 4GR3A 2E2DA 2CLTA 3F17A 4GR0A 3HBUP 3LUMA 3LJZA 4H30A 2AYKA 1JH1A 1MMQA 3K7NA 4WZVA 4GQLA 4GWMA 2YB9A 1H71P 4GF1A 2MZHA 2X3CA 4DPEA 1IAAA 4PKTA 1JANA 3WV3A 3TT4A 1AF0A 3LJTA 2MLRA 2OI0A 3KECA 2N8RA 4AIGA 4ZR5A 1C3IA 2Z2DA 4Q1LA 1ZXVA 3Q2HA 1OZ9A 2OVXA 1KUIA 1XFZA 5I2ZA 5I0LA 1ZXCA 1CXVA 2V4BA 2YUFA 2OXWA 3LILA 1JJ9A 1USNA 2JSDA 2OXUA 1JKYA 4A7BA 3N2VA 3ZXHA 1XFUA 2J0TA 3DTIA 4I03A 3HBVP 1GO8P 4H1QA 1D8MA 5I12A 1KUKA 4CTHA 5BOTA 5D3CA 3P24A 2RJQA 3LQBA 1BQQM 966CA 830CA 4H82A 4JIJA 1C8TA 1I76A 2XS3A 1HOVA 1KUFA 1MMPA 4XM7A 1SLMA 3LIKA 3ZVSA 1BUVM 1O0TA 4IN9A 1UTTA 3LEAA 2OXZA 4WKIA 5D1TA 2W12A 2JT5A 3DWBA 1XM5A 3DL1A 5CZMA
chains in the Genus database with same CATH topology
4H2EA 4HMAA 1D8FA 3HDAP 2SRTA 3KHIA 3LGPA 1R1IA 1A86A 4H84A 1GXDA 3F1AA 5D7WA 1JAOA 2J83A 3UVCA 1R54A 3WV2A 1K7IA 4JP4A 1YCMA 1BQOA 1GE6A 1HV5A 4PKSA 4R3VA 4PKWA 1IAGA 1AYKA 4PKVA 1YP1A 1QIAA 4WK7A 3AYKA 1XUDA 1QUAA 1OS2A 1DTHA 3LQ0A 1CGLA 4DF9A 1I73A 2X3BA 3OHLA 2WOAA 3EDHA 4AYKA 1Z3JA 2RJPA 1ZTQA 1MMRA 4H76A 2DW1A 1BKCI 3B2ZA 3DTEA 1UTZA 1XURA 1EAKA 2Y6CA 4PKQA 1B3DA 3KMEA 2KRJA 3HB2P 3LKAA 2OW0A 1B8YA 1SMPA 2D1OA 3NX7A 3SHIA 1BZSA 1KBCA 1OM6A 1OMJA 1BKCE 3CKIA 1YOUA 3LK8A 1D7XA 2FV5A 3OHOA 3RTTA 5L79A 1ROSA 1OM7A 3L0TA 1K7QA 4L63A 3E8RA 4L7AA 2JIHA 2JNPA 4DV8A 2W14A 1QIBA 4XM6A 1KUGA 1AKLA 1YQYA 1Y8JA 1D5JA 3DSLA 4AUOA 2W15A 1RM8A 1S4BP 2YIGA 3O64A 3I7IA 2DW0A 3LE9A 1KAPP 4GR8A 2MLSA 3DPEA 1Q3AA 4XM8A 5D1SA 2OZRA 2TCLA 3LMCA 1SATA 4HX3A 3EDGA 4G0DA 3KMCA 1DMTA 3AYUA 1C7KA 1HY7A 1HTDA 2A8HA 2HU6A 1FLSA 4I35A 3B92A 2OW1A 5LABA 1CQRA 4FXYP 4EFSA 1GKCA 3GBOA 5H8XA 3V96B 5B5PA 2PJTA 1HFSA 2K9CA 1R55A 4L19A 4XBHA 3RTSA 5D2BA 1Y0VA 5I4OA 4ON1A 2X3AA 4QKZA 2WO8A 2OY4A 1OS9A 2EROA 1EUBA 1ND1A 3HYGA 4H3XA 1IADA 1CK7A 4FU4A 2USNA 1IACA 4L6TA 2ERQA 2CKIA 3Q2GA 2W13A 1PWWA 1MMBA 4A3WA 3TS4A 1IAEA 1G9KA 1PWVA 1XFVA 3G5CA 1IABA 3USNA 1K7GA 2WO9A 1G12A 3DNGA 1KUHA 1WNIA 1UMTA 5L7FA 3G42A 2W0DA 1CGFA 1JAQA 2O3EA 1GO7P 1RMZA 3KWVC 3TSKA 2K2GA 1L6JA 3L0VA 3AIGA 3WV1A 1ZP5A 1BIWA 3F18A 1GKDA 1XUCA 1XFXA 2DDYA 1QJJA 2MZEA 1ATLA 2QPJA 1OO9A 4FVLA 1R1JA 1BKCA 3K7LA 1JAPA 4J4MA 2FV9A 3EDZA 1JIWP 1GE7A 2X7MA 1BM6A 5CXAA 1OM8A 3N2UA 1UMSA 1FM1A 1XFYA 2POJA 3I7GA 3KEKA 1QJIA 2DDFA 1XFWA 5BPAA 2AIGP 2OW9A 4WF6A 2D1NA 1G49A 1SLNA 5BOYA 1PWQA 3EWJA 2JT6A 3P1VA 1I1IP 3U1RA 3DPFA 4ILWD 1ZS0A 4GWNA 1A85A 1UEAA 2OY2A 3F15A 3HY9A 1SU3A 1JK3A 3TVCA 5CUHA 3KEJA 1CGEA 5I3MA 1J7NA 1BSWA 5D1UA 1PWUA 4PKUA 3BA0A 3F19A 2I47A 1HFCA 4JPAA 1ZVXA 2DW2A 5JMYA 2Y6DA 4IUWA 4H49A 4AXQA 5I43A 2OW2A 2XS4A 4DD8A 3HY7A 3EHYA 1JIZA 1SRPA 2O36A 3MA2A 4FXQA 1EB6A 3B8ZA 1FBLA 3DTKA 1G4KA 3F16A 1GE5A 3LIRA 3LUNA 2E3XA 4PKRA 3ELMA 4JA1A 1MNCA 4WKEA 4XCTA 1CAQA 1G05A 5B5OA 1PWPA 1R1HA 1O0QA 3EHXA 1BUDA 3KRYA 2MZIA 2L0RA 2OVZA 3LJGA 3VI1A 456CA 3HDBA 4IJOA 4JQGA 4GUYA 1QICA 1CIZA 3O2XA 1Y93A 3EDIA 4G9LA 1ASTA 2ERPA 3VTGA 3ZUKA 4GR3A 2E2DA 2CLTA 3F17A 4GR0A 3HBUP 3LUMA 3LJZA 4H30A 2AYKA 1JH1A 1MMQA 3K7NA 4WZVA 4GQLA 4GWMA 2YB9A 1H71P 4GF1A 2MZHA 2X3CA 4DPEA 1IAAA 4PKTA 1JANA 3WV3A 3TT4A 1AF0A 3LJTA 2MLRA 2OI0A 3KECA 2N8RA 4AIGA 4ZR5A 1C3IA 2Z2DA 4Q1LA 1ZXVA 3Q2HA 2OVXA 1KUIA 1XFZA 5I2ZA 5I0LA 1ZXCA 1CXVA 2V4BA 2YUFA 2OXWA 3LILA 1JJ9A 1USNA 2JSDA 2OXUA 1JKYA 4A7BA 3N2VA 3ZXHA 1XFUA 2J0TA 3DTIA 4I03A 3HBVP 1GO8P 4H1QA 1D8MA 5I12A 1KUKA 4CTHA 5BOTA 5D3CA 3P24A 2RJQA 3LQBA 1BQQM 966CA 830CA 4H82A 4JIJA 1C8TA 1I76A 2XS3A 1HOVA 1KUFA 1MMPA 4XM7A 1SLMA 3LIKA 3ZVSA 1BUVM 1O0TA 4IN9A 1UTTA 3LEAA 2OXZA 4WKIA 5D1TA 2W12A 2JT5A 3DWBA 3DL1A 5CZMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4H2E A;  4HMA A;  1D8F A;  3HDA P;  2SRT A;  3KHI A;  3LGP A;  1R1I A;  1A86 A;  4H84 A;  1GXD A;  3F1A A;  5D7W A;  1JAO A;  2J83 A;  3UVC A;  1R54 A;  3WV2 A;  1K7I A;  4JP4 A;  1YCM A;  1BQO A;  1GE6 A;  1HV5 A;  4PKS A;  4R3V A;  4PKW A;  1IAG A;  1AYK A;  4PKV A;  1YP1 A;  1QIA A;  4WK7 A;  3AYK A;  1XUD A;  1QUA A;  1OS2 A;  1DTH A;  3LQ0 A;  1CGL A;  4DF9 A;  1I73 A;  2X3B A;  3OHL A;  2WOA A;  3EDH A;  4AYK A;  1Z3J A;  2RJP A;  1ZTQ A;  1MMR A;  4H76 A;  2DW1 A;  1BKC I;  3B2Z A;  1UTZ A;  1XUR A;  1EAK A;  2Y6C A;  4PKQ A;  1B3D A;  3KME A;  2KRJ A;  3HB2 P;  3LKA A;  2OW0 A;  1B8Y A;  1SMP A;  2D1O A;  3NX7 A;  3SHI A;  1BZS A;  1KBC A;  1OM6 A;  1OMJ A;  1BKC E;  3CKI A;  1YOU A;  3LK8 A;  1D7X A;  2FV5 A;  3OHO A;  3RTT A;  5L79 A;  1ROS A;  1OM7 A;  3L0T A;  1K7Q A;  4L63 A;  3E8R A;  2JIH A;  2JNP A;  4DV8 A;  2W14 A;  1QIB A;  4XM6 A;  1KUG A;  1AKL A;  1YQY A;  1Y8J A;  1D5J A;  3DSL A;  4AUO A;  2W15 A;  1RM8 A;  1S4B P;  2YIG A;  3O64 A;  3I7I A;  2DW0 A;  3LE9 A;  1KAP P;  4GR8 A;  2MLS A;  3DPE A;  1Q3A A;  4XM8 A;  5D1S A;  2OZR A;  2TCL A;  3LMC A;  1SAT A;  4HX3 A;  3EDG A;  4G0D A;  3KMC A;  1DMT A;  3AYU A;  1C7K A;  1HY7 A;  1HTD A;  2A8H A;  2HU6 A;  1FLS A;  4I35 A;  3B92 A;  2OW1 A;  5LAB A;  1CQR A;  4FXY P;  4EFS A;  1GKC A;  3GBO A;  5H8X A;  3V96 B;  5B5P A;  2PJT A;  1HFS A;  2K9C A;  1R55 A;  4L19 A;  4XBH A;  3RTS A;  5D2B A;  1Y0V A;  5I4O A;  4ON1 A;  2X3A A;  4QKZ A;  2WO8 A;  2OY4 A;  1OS9 A;  2ERO A;  1EUB A;  1ND1 A;  3HYG A;  4H3X A;  1IAD A;  1CK7 A;  4FU4 A;  2USN A;  1IAC A;  4L6T A;  2ERQ A;  2CKI A;  3Q2G A;  2W13 A;  1PWW A;  1MMB A;  4A3W A;  3TS4 A;  1IAE A;  1G9K A;  1PWV A;  1XFV A;  3G5C A;  1IAB A;  3USN A;  1K7G A;  2WO9 A;  1G12 A;  3DNG A;  1KUH A;  1WNI A;  1UMT A;  5L7F A;  3G42 A;  2W0D A;  1CGF A;  1JAQ A;  2O3E A;  1GO7 P;  1RMZ A;  3KWV C;  3TSK A;  2K2G A;  1L6J A;  3L0V A;  3AIG A;  3WV1 A;  1ZP5 A;  1BIW A;  3F18 A;  1GKD A;  1XUC A;  1XFX A;  2DDY A;  1QJJ A;  2MZE A;  1ATL A;  2QPJ A;  1OO9 A;  4FVL A;  1R1J A;  1BKC A;  3K7L A;  1JAP A;  4J4M A;  2FV9 A;  3EDZ A;  1JIW P;  1GE7 A;  2X7M A;  1BM6 A;  5CXA A;  1OM8 A;  3N2U A;  1UMS A;  1FM1 A;  1XFY A;  2POJ A;  3I7G A;  3KEK A;  1QJI A;  2DDF A;  1XFW A;  5BPA A;  2AIG P;  2OW9 A;  4WF6 A;  2D1N A;  1G49 A;  1SLN A;  5BOY A;  1PWQ A;  3EWJ A;  2JT6 A;  3P1V A;  1I1I P;  3U1R A;  3DPF A;  4ILW D;  1ZS0 A;  4GWN A;  1A85 A;  1UEA A;  2OY2 A;  3F15 A;  3HY9 A;  1SU3 A;  1JK3 A;  3TVC A;  5CUH A;  3KEJ A;  1CGE A;  5I3M A;  1J7N A;  1BSW A;  5D1U A;  1PWU A;  4PKU A;  3BA0 A;  3F19 A;  2I47 A;  1HFC A;  4JPA A;  1ZVX A;  2DW2 A;  5JMY A;  2Y6D A;  4IUW A;  4H49 A;  4AXQ A;  5I43 A;  2OW2 A;  2XS4 A;  4DD8 A;  3HY7 A;  3EHY A;  1JIZ A;  1SRP A;  2O36 A;  3MA2 A;  4FXQ A;  1EB6 A;  3B8Z A;  1FBL A;  1G4K A;  3F16 A;  1GE5 A;  3LIR A;  3LUN A;  2E3X A;  4PKR A;  3ELM A;  4JA1 A;  1MNC A;  4WKE A;  4XCT A;  1CAQ A;  1G05 A;  5B5O A;  1PWP A;  1R1H A;  1O0Q A;  3EHX A;  1BUD A;  3KRY A;  2MZI A;  2L0R A;  2OVZ A;  3LJG A;  3VI1 A;  456C A;  3HDB A;  4IJO A;  4JQG A;  4GUY A;  1QIC A;  1CIZ A;  3O2X A;  1Y93 A;  3EDI A;  4G9L A;  1AST A;  2ERP A;  3VTG A;  3ZUK A;  4GR3 A;  2E2D A;  2CLT A;  3F17 A;  4GR0 A;  3HBU P;  3LUM A;  3LJZ A;  4H30 A;  2AYK A;  1JH1 A;  1MMQ A;  3K7N A;  4WZV A;  4GQL A;  4GWM A;  2YB9 A;  1H71 P;  4GF1 A;  2MZH A;  2X3C A;  4DPE A;  1IAA A;  4PKT A;  1JAN A;  3WV3 A;  3TT4 A;  1AF0 A;  3LJT A;  2MLR A;  2OI0 A;  3KEC A;  2N8R A;  4AIG A;  4ZR5 A;  1C3I A;  2Z2D A;  4Q1L A;  1ZXV A;  3Q2H A;  2OVX A;  1KUI A;  1XFZ A;  5I2Z A;  5I0L A;  1ZXC A;  1CXV A;  2V4B A;  2OXW A;  3LIL A;  1JJ9 A;  1USN A;  2JSD A;  2OXU A;  1JKY A;  4A7B A;  3N2V A;  3ZXH A;  1XFU A;  2J0T A;  4I03 A;  3HBV P;  1GO8 P;  4H1Q A;  1D8M A;  5I12 A;  1KUK A;  4CTH A;  5BOT A;  5D3C A;  3P24 A;  2RJQ A;  3LQB A;  1BQQ M;  966C A;  830C A;  4H82 A;  4JIJ A;  1C8T A;  1I76 A;  2XS3 A;  1HOV A;  1KUF A;  1MMP A;  4XM7 A;  1SLM A;  3LIK A;  3ZVS A;  1BUV M;  1O0T A;  4IN9 A;  1UTT A;  3LEA A;  2OXZ A;  4WKI A;  5D1T A;  2W12 A;  2JT5 A;  3DWB A;  3DL1 A;  5CZM A; 
#chains in the Genus database with same CATH topology
 4H2E A;  4HMA A;  1D8F A;  3HDA P;  2SRT A;  3KHI A;  3LGP A;  1R1I A;  1A86 A;  4H84 A;  1GXD A;  3F1A A;  5D7W A;  1JAO A;  2J83 A;  3UVC A;  1R54 A;  3WV2 A;  1K7I A;  4JP4 A;  1YCM A;  1BQO A;  1GE6 A;  1HV5 A;  4PKS A;  4R3V A;  4PKW A;  1IAG A;  1AYK A;  4PKV A;  1YP1 A;  1QIA A;  4WK7 A;  3AYK A;  1XUD A;  1QUA A;  1OS2 A;  1DTH A;  3LQ0 A;  1CGL A;  4DF9 A;  1I73 A;  2X3B A;  3OHL A;  1XAX A;  2WOA A;  3EDH A;  4AYK A;  1Z3J A;  2RJP A;  1ZTQ A;  1MMR A;  4H76 A;  2DW1 A;  1BKC I;  3B2Z A;  3DTE A;  1UTZ A;  1XUR A;  1EAK A;  2Y6C A;  4PKQ A;  1B3D A;  3KME A;  2KRJ A;  3HB2 P;  3LKA A;  2OW0 A;  1B8Y A;  1SMP A;  2D1O A;  3NX7 A;  3SHI A;  1BZS A;  1KBC A;  1OM6 A;  1OMJ A;  1BKC E;  3CKI A;  1YOU A;  3LK8 A;  1D7X A;  2FV5 A;  3OHO A;  3RTT A;  5L79 A;  1ROS A;  1OM7 A;  3L0T A;  1K7Q A;  4L63 A;  3E8R A;  4L7A A;  2JIH A;  2JNP A;  4DV8 A;  2W14 A;  1QIB A;  4XM6 A;  1KUG A;  1AKL A;  1YQY A;  1Y8J A;  1D5J A;  3DSL A;  4AUO A;  2W15 A;  1RM8 A;  1S4B P;  2YIG A;  3O64 A;  3I7I A;  2DW0 A;  3LE9 A;  1KAP P;  4GR8 A;  2MLS A;  3DPE A;  1Q3A A;  4XM8 A;  5D1S A;  2OZR A;  2TCL A;  3LMC A;  1SAT A;  4HX3 A;  3EDG A;  4G0D A;  3KMC A;  1DMT A;  3AYU A;  1C7K A;  1HY7 A;  1HTD A;  2A8H A;  2HU6 A;  1FLS A;  4I35 A;  3B92 A;  2OW1 A;  5LAB A;  1CQR A;  4FXY P;  4EFS A;  1GKC A;  3GBO A;  5H8X A;  3V96 B;  5B5P A;  2PJT A;  1HFS A;  2K9C A;  1R55 A;  4L19 A;  4XBH A;  3RTS A;  5D2B A;  1Y0V A;  5I4O A;  4ON1 A;  2X3A A;  4QKZ A;  2WO8 A;  2OY4 A;  1OS9 A;  2ERO A;  1EUB A;  1ND1 A;  3HYG A;  4H3X A;  1IAD A;  1CK7 A;  4FU4 A;  2USN A;  1IAC A;  4L6T A;  2ERQ A;  2CKI A;  3Q2G A;  2W13 A;  1PWW A;  1MMB A;  4A3W A;  1TVI A;  3TS4 A;  1IAE A;  1G9K A;  1PWV A;  1XFV A;  3G5C A;  1IAB A;  3USN A;  1K7G A;  2WO9 A;  1G12 A;  3DNG A;  1KUH A;  1WNI A;  1UMT A;  5L7F A;  3G42 A;  2W0D A;  1CGF A;  1JAQ A;  2O3E A;  1GO7 P;  1RMZ A;  3KWV C;  3TSK A;  2K2G A;  1L6J A;  3L0V A;  3AIG A;  3WV1 A;  1ZP5 A;  1BIW A;  3F18 A;  1GKD A;  1XUC A;  1XFX A;  2DDY A;  1QJJ A;  2MZE A;  1ATL A;  2QPJ A;  1OO9 A;  4FVL A;  1R1J A;  1BKC A;  3K7L A;  1JAP A;  4J4M A;  2FV9 A;  3EDZ A;  1JIW P;  1GE7 A;  2X7M A;  1BM6 A;  5CXA A;  1OM8 A;  3N2U A;  1UMS A;  1FM1 A;  1XFY A;  2POJ A;  3I7G A;  3KEK A;  1QJI A;  2DDF A;  1XFW A;  5BPA A;  2AIG P;  2OW9 A;  4WF6 A;  2D1N A;  1G49 A;  1SLN A;  5BOY A;  1PWQ A;  3EWJ A;  2JT6 A;  3P1V A;  1I1I P;  3U1R A;  3DPF A;  4ILW D;  1ZS0 A;  4GWN A;  1A85 A;  1UEA A;  2OY2 A;  3F15 A;  3HY9 A;  1SU3 A;  1JK3 A;  3TVC A;  5CUH A;  3KEJ A;  1CGE A;  5I3M A;  1J7N A;  1BSW A;  5D1U A;  1PWU A;  4PKU A;  3BA0 A;  3F19 A;  2I47 A;  1HFC A;  4JPA A;  1ZVX A;  2DW2 A;  5JMY A;  2Y6D A;  4IUW A;  4H49 A;  4AXQ A;  5I43 A;  2OW2 A;  2XS4 A;  4DD8 A;  3HY7 A;  3EHY A;  1JIZ A;  1SRP A;  2O36 A;  3MA2 A;  4FXQ A;  1EB6 A;  3B8Z A;  1FBL A;  3DTK A;  1G4K A;  3F16 A;  1GE5 A;  3LIR A;  3LUN A;  2E3X A;  4PKR A;  3ELM A;  4JA1 A;  1MNC A;  4WKE A;  4XCT A;  1CAQ A;  1G05 A;  5B5O A;  1PWP A;  1R1H A;  1O0Q A;  3EHX A;  1BUD A;  3KRY A;  2MZI A;  2L0R A;  2OVZ A;  3LJG A;  3VI1 A;  456C A;  3HDB A;  4IJO A;  4JQG A;  4GUY A;  1QIC A;  1CIZ A;  3O2X A;  1Y93 A;  3EDI A;  4G9L A;  1AST A;  2ERP A;  3VTG A;  3ZUK A;  4GR3 A;  2E2D A;  2CLT A;  3F17 A;  4GR0 A;  3HBU P;  3LUM A;  3LJZ A;  4H30 A;  2AYK A;  1JH1 A;  1MMQ A;  3K7N A;  4WZV A;  4GQL A;  4GWM A;  2YB9 A;  1H71 P;  4GF1 A;  2MZH A;  2X3C A;  4DPE A;  1IAA A;  4PKT A;  1JAN A;  3WV3 A;  3TT4 A;  1AF0 A;  3LJT A;  2MLR A;  2OI0 A;  3KEC A;  2N8R A;  4AIG A;  4ZR5 A;  1C3I A;  2Z2D A;  4Q1L A;  1ZXV A;  3Q2H A;  1OZ9 A;  2OVX A;  1KUI A;  1XFZ A;  5I2Z A;  5I0L A;  1ZXC A;  1CXV A;  2V4B A;  2YUF A;  2OXW A;  3LIL A;  1JJ9 A;  1USN A;  2JSD A;  2OXU A;  1JKY A;  4A7B A;  3N2V A;  3ZXH A;  1XFU A;  2J0T A;  3DTI A;  4I03 A;  3HBV P;  1GO8 P;  4H1Q A;  1D8M A;  5I12 A;  1KUK A;  4CTH A;  5BOT A;  5D3C A;  3P24 A;  2RJQ A;  3LQB A;  1BQQ M;  966C A;  830C A;  4H82 A;  4JIJ A;  1C8T A;  1I76 A;  2XS3 A;  1HOV A;  1KUF A;  1MMP A;  4XM7 A;  1SLM A;  3LIK A;  3ZVS A;  1BUV M;  1O0T A;  4IN9 A;  1UTT A;  3LEA A;  2OXZ A;  4WKI A;  5D1T A;  2W12 A;  2JT5 A;  3DWB A;  1XM5 A;  3DL1 A;  5CZM A; 
#chains in the Genus database with same CATH homology
 4H2E A;  4HMA A;  1D8F A;  3HDA P;  2SRT A;  3KHI A;  3LGP A;  1R1I A;  1A86 A;  4H84 A;  1GXD A;  3F1A A;  5D7W A;  1JAO A;  2J83 A;  3UVC A;  1R54 A;  3WV2 A;  1K7I A;  4JP4 A;  1YCM A;  1BQO A;  1GE6 A;  1HV5 A;  4PKS A;  4R3V A;  4PKW A;  1IAG A;  1AYK A;  4PKV A;  1YP1 A;  1QIA A;  4WK7 A;  3AYK A;  1XUD A;  1QUA A;  1OS2 A;  1DTH A;  3LQ0 A;  1CGL A;  4DF9 A;  1I73 A;  2X3B A;  3OHL A;  2WOA A;  3EDH A;  4AYK A;  1Z3J A;  2RJP A;  1ZTQ A;  1MMR A;  4H76 A;  2DW1 A;  1BKC I;  3B2Z A;  3DTE A;  1UTZ A;  1XUR A;  1EAK A;  2Y6C A;  4PKQ A;  1B3D A;  3KME A;  2KRJ A;  3HB2 P;  3LKA A;  2OW0 A;  1B8Y A;  1SMP A;  2D1O A;  3NX7 A;  3SHI A;  1BZS A;  1KBC A;  1OM6 A;  1OMJ A;  1BKC E;  3CKI A;  1YOU A;  3LK8 A;  1D7X A;  2FV5 A;  3OHO A;  3RTT A;  5L79 A;  1ROS A;  1OM7 A;  3L0T A;  1K7Q A;  4L63 A;  3E8R A;  4L7A A;  2JIH A;  2JNP A;  4DV8 A;  2W14 A;  1QIB A;  4XM6 A;  1KUG A;  1AKL A;  1YQY A;  1Y8J A;  1D5J A;  3DSL A;  4AUO A;  2W15 A;  1RM8 A;  1S4B P;  2YIG A;  3O64 A;  3I7I A;  2DW0 A;  3LE9 A;  1KAP P;  4GR8 A;  2MLS A;  3DPE A;  1Q3A A;  4XM8 A;  5D1S A;  2OZR A;  2TCL A;  3LMC A;  1SAT A;  4HX3 A;  3EDG A;  4G0D A;  3KMC A;  1DMT A;  3AYU A;  1C7K A;  1HY7 A;  1HTD A;  2A8H A;  2HU6 A;  1FLS A;  4I35 A;  3B92 A;  2OW1 A;  5LAB A;  1CQR A;  4FXY P;  4EFS A;  1GKC A;  3GBO A;  5H8X A;  3V96 B;  5B5P A;  2PJT A;  1HFS A;  2K9C A;  1R55 A;  4L19 A;  4XBH A;  3RTS A;  5D2B A;  1Y0V A;  5I4O A;  4ON1 A;  2X3A A;  4QKZ A;  2WO8 A;  2OY4 A;  1OS9 A;  2ERO A;  1EUB A;  1ND1 A;  3HYG A;  4H3X A;  1IAD A;  1CK7 A;  4FU4 A;  2USN A;  1IAC A;  4L6T A;  2ERQ A;  2CKI A;  3Q2G A;  2W13 A;  1PWW A;  1MMB A;  4A3W A;  3TS4 A;  1IAE A;  1G9K A;  1PWV A;  1XFV A;  3G5C A;  1IAB A;  3USN A;  1K7G A;  2WO9 A;  1G12 A;  3DNG A;  1KUH A;  1WNI A;  1UMT A;  5L7F A;  3G42 A;  2W0D A;  1CGF A;  1JAQ A;  2O3E A;  1GO7 P;  1RMZ A;  3KWV C;  3TSK A;  2K2G A;  1L6J A;  3L0V A;  3AIG A;  3WV1 A;  1ZP5 A;  1BIW A;  3F18 A;  1GKD A;  1XUC A;  1XFX A;  2DDY A;  1QJJ A;  2MZE A;  1ATL A;  2QPJ A;  1OO9 A;  4FVL A;  1R1J A;  1BKC A;  3K7L A;  1JAP A;  4J4M A;  2FV9 A;  3EDZ A;  1JIW P;  1GE7 A;  2X7M A;  1BM6 A;  5CXA A;  1OM8 A;  3N2U A;  1UMS A;  1FM1 A;  1XFY A;  2POJ A;  3I7G A;  3KEK A;  1QJI A;  2DDF A;  1XFW A;  5BPA A;  2AIG P;  2OW9 A;  4WF6 A;  2D1N A;  1G49 A;  1SLN A;  5BOY A;  1PWQ A;  3EWJ A;  2JT6 A;  3P1V A;  1I1I P;  3U1R A;  3DPF A;  4ILW D;  1ZS0 A;  4GWN A;  1A85 A;  1UEA A;  2OY2 A;  3F15 A;  3HY9 A;  1SU3 A;  1JK3 A;  3TVC A;  5CUH A;  3KEJ A;  1CGE A;  5I3M A;  1J7N A;  1BSW A;  5D1U A;  1PWU A;  4PKU A;  3BA0 A;  3F19 A;  2I47 A;  1HFC A;  4JPA A;  1ZVX A;  2DW2 A;  5JMY A;  2Y6D A;  4IUW A;  4H49 A;  4AXQ A;  5I43 A;  2OW2 A;  2XS4 A;  4DD8 A;  3HY7 A;  3EHY A;  1JIZ A;  1SRP A;  2O36 A;  3MA2 A;  4FXQ A;  1EB6 A;  3B8Z A;  1FBL A;  3DTK A;  1G4K A;  3F16 A;  1GE5 A;  3LIR A;  3LUN A;  2E3X A;  4PKR A;  3ELM A;  4JA1 A;  1MNC A;  4WKE A;  4XCT A;  1CAQ A;  1G05 A;  5B5O A;  1PWP A;  1R1H A;  1O0Q A;  3EHX A;  1BUD A;  3KRY A;  2MZI A;  2L0R A;  2OVZ A;  3LJG A;  3VI1 A;  456C A;  3HDB A;  4IJO A;  4JQG A;  4GUY A;  1QIC A;  1CIZ A;  3O2X A;  1Y93 A;  3EDI A;  4G9L A;  1AST A;  2ERP A;  3VTG A;  3ZUK A;  4GR3 A;  2E2D A;  2CLT A;  3F17 A;  4GR0 A;  3HBU P;  3LUM A;  3LJZ A;  4H30 A;  2AYK A;  1JH1 A;  1MMQ A;  3K7N A;  4WZV A;  4GQL A;  4GWM A;  2YB9 A;  1H71 P;  4GF1 A;  2MZH A;  2X3C A;  4DPE A;  1IAA A;  4PKT A;  1JAN A;  3WV3 A;  3TT4 A;  1AF0 A;  3LJT A;  2MLR A;  2OI0 A;  3KEC A;  2N8R A;  4AIG A;  4ZR5 A;  1C3I A;  2Z2D A;  4Q1L A;  1ZXV A;  3Q2H A;  2OVX A;  1KUI A;  1XFZ A;  5I2Z A;  5I0L A;  1ZXC A;  1CXV A;  2V4B A;  2YUF A;  2OXW A;  3LIL A;  1JJ9 A;  1USN A;  2JSD A;  2OXU A;  1JKY A;  4A7B A;  3N2V A;  3ZXH A;  1XFU A;  2J0T A;  3DTI A;  4I03 A;  3HBV P;  1GO8 P;  4H1Q A;  1D8M A;  5I12 A;  1KUK A;  4CTH A;  5BOT A;  5D3C A;  3P24 A;  2RJQ A;  3LQB A;  1BQQ M;  966C A;  830C A;  4H82 A;  4JIJ A;  1C8T A;  1I76 A;  2XS3 A;  1HOV A;  1KUF A;  1MMP A;  4XM7 A;  1SLM A;  3LIK A;  3ZVS A;  1BUV M;  1O0T A;  4IN9 A;  1UTT A;  3LEA A;  2OXZ A;  4WKI A;  5D1T A;  2W12 A;  2JT5 A;  3DWB A;  3DL1 A;  5CZM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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