4WKIA

Crystal structure of human adamts-4 in complex with inhibitor 5-chloro-n-{[(4s)-4-(1-methyl-1h-imidazol-2-yl)-2,5-dioxoimidazolidin-4-yl]methyl}-1-benzofuran-2-carboxamide (compound 11)
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
221
structure length
214
Chain Sequence
SLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
pubmed doi rcsb
molecule keywords A disintegrin and metalloproteinase with thrombospondin moti
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
total genus 70
structure length 214
sequence length 221
ec nomenclature ec 3.4.24.82: ADAMTS-4 endopeptidase.
pdb deposition date 2014-10-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01421 Reprolysin Reprolysin (M12B) family zinc metalloprotease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 4wkiA00
1SLMA 4GUYA 2A8HA 1QJIA 1YP1A 4GR3A 1IAAA 4R3VA 1JKYA 1FM1A 1ATLA 4DD8A 5L7FA 2K2GA 1PWWA 1SMPA 3HDBA 3I7IA 1BUVM 2OY4A 1DTHA 4A7BA 2O3EA 3TT4A 1HOVA 2MZHA 4GR0A 1BQOA 1GE5A 2CKIA 3WV3A 1IAEA 1XFZA 5D2BA 1OO9A 1I73A 1OMJA 1D8FA 1Y0VA 4PKUA 1O0QA 4G9LA 1G49A 5D3CA 3HB2P 2FV9A 1AYKA 1IABA 2W12A 4XM6A 1BSWA 2X3AA 1G05A 4AUOA 3LUMA 1KUHA 1G4KA 5JMYA 3LQBA 2RJQA 4DPEA 3NX7A 2W15A 3N2VA 1CAQA 3OHOA 4IUWA 4H82A 2D1OA 5CXAA 1J7NA 3LE9A 3F17A 4L63A 3ZVSA 1KUFA 1PWQA 1HTDA 3EHXA 3EHYA 4CTHA 1QIAA 1O0TA 5H8XA 2Y6CA 2JT6A 4XM7A 4PKRA 2PJTA 1OS2A 2JNPA 3KEKA 1IACA 1JAQA 2OW0A 4IN9A 2W13A 1G12A 3OHLA 3AIGA 3LEAA 4AIGA 1MMBA 2YB9A 2D1NA 5BPAA 4FXYP 1R1HA 1YQYA 1BIWA 1AKLA 3EDHA 2MLRA 3P24A 3K7LA 2ERQA 2OI0A 3KMCA 3RTSA 2DW0A 4H84A 4J4MA 3O64A 4GWNA 1SATA 1C7KA 4I35A 4DV8A 1JJ9A 4WK7A 3B2ZA 1SU3A 1RMZA 3KRYA 1JH1A 1OM7A 2MZIA 1B8YA 1JIZA 1MMQA 2J0TA 2TCLA 2JIHA 3DNGA 1CQRA 3G5CA 3ZXHA 5LABA 1UTZA 4XM8A 1BKCA 3B8ZA 1Q3AA 2OZRA 2X7MA 5B5PA 4H1QA 3SHIA 2OXUA 3DWBA 4QKZA 5I0LA 1ZS0A 4PKTA 1CK7A 2N8RA 1OM6A 1UEAA 2MLSA 2E2DA 5I4OA 3TS4A 1GKDA 3HBVP 3MA2A 3EDZA 4WF6A 1AF0A 3TVCA 1ASTA 1ROSA 1MMRA 1Y93A 1QJJA 2J83A 4WKIA 2OXZA 2EROA 1HY7A 1OS9A 1EUBA 4GR8A 2I47A 3HBUP 1K7IA 1L6JA 5D1UA 2HU6A 456CA 1KAPP 2JT5A 3F18A 1GKCA 5CUHA 1CGEA 1BZSA 3O2XA 1JK3A 3KHIA 1JAPA 830CA 2W0DA 3TSKA 3HY9A 4H30A 1XFVA 3EDGA 4G0DA 1C3IA 4FU4A 3LGPA 3HYGA 1PWPA 4ZR5A 4AYKA 1XUDA 1K7QA 1K7GA 3LILA 1FLSA 3EWJA 3DSLA 1ZP5A 2DDFA 2WO8A 4HX3A 1ZVXA 1KBCA 3AYKA 2AIGP 2USNA 2MZEA 2DW1A 1GO8P 4ILWD 1GE6A 1ZXVA 4JA1A 4ON1A 1CGFA 3U1RA 3UVCA 5I12A 2ERPA 2Z2DA 1QICA 3F15A 2V4BA 4IJOA 4JIJA 1A86A 1FBLA 1IAGA 4GQLA 3LJTA 2X3BA 2YIGA 3F1AA 3F16A 5BOYA 2OW1A 3HDAP 3LIKA 3ZUKA 1UTTA 2WO9A 3V96B 1BUDA 2OVZA 1HV5A 1CXVA 4H3XA 3LJZA 4L19A 1RM8A 1I1IP 3RTTA 1S4BP 1QIBA 2FV5A 4FXQA 5I2ZA 1R55A 1PWVA 1CGLA 2W14A 1WNIA 1H71P 3DL1A 5CZMA 2K9CA 3KWVC 4PKSA 5D1SA 2Y6DA 1KUKA 3E8RA 4H49A 4L6TA 1R1IA 1XFWA 3I7GA 5D1TA 3AYUA 4JP4A 2OW9A 1XFXA 2X3CA 5L79A 2AYKA 1BKCI 2OXWA 3HY7A 3LK8A 1XFUA 1I76A 3L0TA 2CLTA 1Z3JA 1MNCA 5I3MA 1GE7A 3LUNA 3B92A 2E3XA 4WZVA 4XBHA 1GXDA 3VTGA 1BQQM 3Q2GA 2L0RA 1KUGA 2JSDA 1EB6A 3VI1A 2O36A 3GBOA 1B3DA 1KUIA 1BKCE 3LKAA 2KRJA 1CIZA 3DPFA 3G42A 3WV2A 1JIWP 3CKIA 3LMCA 1JAOA 2OY2A 1ZXCA 4FVLA 4I03A 4JPAA 3ELMA 2POJA 3EDIA 1R1JA 4H76A 2SRTA 3KECA 1IADA 4PKWA 5BOTA 3LQ0A 1SRPA 2DDYA 1ZTQA 4HMAA 1HFCA 3BA0A 1YCMA 2RJPA 2OVXA 2WOAA 3N2UA 1A85A 1MMPA 1Y8JA 4GWMA 1G9KA 1XURA 3F19A 1BM6A 1USNA 4PKQA 1YOUA 1R54A 1EAKA 2XS4A 4EFSA 4Q1LA 4AXQA 1SLNA 1C8TA 1XUCA 1JANA 2QPJA 1ND1A 4WKEA 1UMTA 1D5JA 1D7XA 3LJGA 1OM8A 4XCTA 3WV1A 2OW2A 966CA 1PWUA 4DF9A 4A3WA 5I43A 1D8MA 3Q2HA 3K7NA 4GF1A 5B5OA 1HFSA 3KMEA 4JQGA 3L0VA 3DPEA 1DMTA 1QUAA 3P1VA 3USNA 4PKVA 3KEJA 2XS3A 1GO7P 4H2EA 5D7WA 1XFYA 2DW2A 3LIRA 1UMSA
chains in the Genus database with same CATH superfamily
1SLMA 4GUYA 2A8HA 1QJIA 1YP1A 4GR3A 1IAAA 4R3VA 1JKYA 1FM1A 1ATLA 4DD8A 5L7FA 2K2GA 1PWWA 1SMPA 3HDBA 3I7IA 1BUVM 2OY4A 1DTHA 4A7BA 2O3EA 3TT4A 1HOVA 2MZHA 4GR0A 1BQOA 1GE5A 2CKIA 3WV3A 1IAEA 1XFZA 5D2BA 1OO9A 1I73A 1OMJA 1D8FA 1Y0VA 4PKUA 1O0QA 4G9LA 1G49A 5D3CA 3HB2P 2FV9A 1AYKA 1IABA 2W12A 4XM6A 1BSWA 2X3AA 1G05A 4AUOA 3LUMA 1KUHA 1G4KA 5JMYA 3LQBA 2RJQA 4DPEA 3NX7A 2W15A 3N2VA 1CAQA 3OHOA 4IUWA 4H82A 2D1OA 5CXAA 1J7NA 3LE9A 3F17A 3DTIA 4L63A 3ZVSA 1KUFA 1PWQA 1HTDA 3EHXA 3DTKA 3EHYA 4CTHA 1QIAA 1O0TA 5H8XA 2Y6CA 2JT6A 4XM7A 4PKRA 2PJTA 1OS2A 2JNPA 3KEKA 1IACA 1JAQA 2OW0A 4IN9A 2W13A 1G12A 3OHLA 3AIGA 3LEAA 4AIGA 1MMBA 2YB9A 2D1NA 5BPAA 4FXYP 1R1HA 1YQYA 1BIWA 1AKLA 3EDHA 2MLRA 3P24A 3K7LA 2ERQA 2OI0A 3KMCA 3RTSA 2DW0A 4H84A 4J4MA 3O64A 4GWNA 1SATA 1C7KA 4I35A 4DV8A 1JJ9A 4WK7A 3B2ZA 1SU3A 1RMZA 3KRYA 1JH1A 1OM7A 2MZIA 1B8YA 1JIZA 1MMQA 2J0TA 4L7AA 2TCLA 2JIHA 3DNGA 1CQRA 3G5CA 3ZXHA 5LABA 1UTZA 4XM8A 1BKCA 3B8ZA 1Q3AA 2OZRA 2X7MA 5B5PA 4H1QA 3SHIA 2OXUA 3DWBA 4QKZA 5I0LA 1ZS0A 4PKTA 1CK7A 2N8RA 1OM6A 1UEAA 2MLSA 2E2DA 5I4OA 3TS4A 1GKDA 1OZ9A 3HBVP 3MA2A 3EDZA 4WF6A 1AF0A 3TVCA 1ASTA 1ROSA 1MMRA 1Y93A 1QJJA 2J83A 4WKIA 2OXZA 2EROA 1HY7A 1OS9A 1EUBA 4GR8A 2I47A 3HBUP 1K7IA 1L6JA 5D1UA 2HU6A 456CA 1KAPP 2JT5A 3F18A 1GKCA 5CUHA 1CGEA 1BZSA 3O2XA 1JK3A 3KHIA 1JAPA 830CA 2W0DA 3TSKA 3HY9A 4H30A 1XFVA 3EDGA 4G0DA 1C3IA 4FU4A 3LGPA 3HYGA 1PWPA 4ZR5A 4AYKA 1XUDA 1K7QA 1K7GA 3LILA 1FLSA 3EWJA 3DSLA 1XAXA 1ZP5A 2DDFA 2WO8A 4HX3A 1ZVXA 1KBCA 3AYKA 3DTEA 2AIGP 2USNA 2MZEA 2DW1A 1GO8P 4ILWD 1GE6A 1ZXVA 4JA1A 4ON1A 1CGFA 3U1RA 3UVCA 5I12A 2ERPA 2Z2DA 1QICA 3F15A 2V4BA 4IJOA 4JIJA 1A86A 1FBLA 1IAGA 4GQLA 3LJTA 2X3BA 2YIGA 3F1AA 3F16A 5BOYA 2OW1A 3HDAP 3LIKA 3ZUKA 1UTTA 2WO9A 3V96B 1BUDA 2OVZA 1HV5A 1CXVA 4H3XA 3LJZA 4L19A 1RM8A 1I1IP 3RTTA 1S4BP 1QIBA 2FV5A 4FXQA 5I2ZA 1R55A 1PWVA 1CGLA 2W14A 1WNIA 1H71P 3DL1A 5CZMA 2K9CA 3KWVC 4PKSA 5D1SA 1XM5A 2Y6DA 1KUKA 3E8RA 4H49A 4L6TA 1R1IA 1XFWA 3I7GA 5D1TA 3AYUA 4JP4A 2OW9A 1XFXA 2YUFA 2X3CA 5L79A 2AYKA 1BKCI 2OXWA 3HY7A 3LK8A 1XFUA 1I76A 3L0TA 2CLTA 1Z3JA 1MNCA 5I3MA 1GE7A 3LUNA 3B92A 2E3XA 4WZVA 4XBHA 1GXDA 3VTGA 1BQQM 3Q2GA 2L0RA 1KUGA 2JSDA 1EB6A 3VI1A 2O36A 3GBOA 1B3DA 1KUIA 1BKCE 3LKAA 2KRJA 1CIZA 3DPFA 3G42A 3WV2A 1JIWP 3CKIA 3LMCA 1JAOA 2OY2A 1ZXCA 4FVLA 1TVIA 4I03A 4JPAA 3ELMA 2POJA 3EDIA 1R1JA 4H76A 2SRTA 3KECA 1IADA 4PKWA 5BOTA 3LQ0A 1SRPA 2DDYA 1ZTQA 4HMAA 1HFCA 3BA0A 1YCMA 2RJPA 2OVXA 2WOAA 3N2UA 1A85A 1MMPA 1Y8JA 4GWMA 1G9KA 1XURA 3F19A 1BM6A 1USNA 4PKQA 1YOUA 1R54A 1EAKA 2XS4A 4EFSA 4Q1LA 4AXQA 1SLNA 1C8TA 1XUCA 1JANA 2QPJA 1ND1A 4WKEA 1UMTA 1D5JA 1D7XA 3LJGA 1OM8A 4XCTA 3WV1A 2OW2A 966CA 1PWUA 4DF9A 4A3WA 5I43A 1D8MA 3Q2HA 3K7NA 4GF1A 5B5OA 1HFSA 3KMEA 4JQGA 3L0VA 3DPEA 1DMTA 1QUAA 3P1VA 3USNA 4PKVA 3KEJA 2XS3A 1GO7P 4H2EA 5D7WA 1XFYA 2DW2A 3LIRA 1UMSA
chains in the Genus database with same CATH topology
1SLMA 4GUYA 2A8HA 1QJIA 1YP1A 4GR3A 1IAAA 4R3VA 1JKYA 1FM1A 1ATLA 4DD8A 5L7FA 2K2GA 1PWWA 1SMPA 3HDBA 3I7IA 1BUVM 2OY4A 1DTHA 4A7BA 2O3EA 3TT4A 1HOVA 2MZHA 4GR0A 1BQOA 1GE5A 2CKIA 3WV3A 1IAEA 1XFZA 5D2BA 1OO9A 1I73A 1OMJA 1D8FA 1Y0VA 4PKUA 1O0QA 4G9LA 1G49A 5D3CA 3HB2P 2FV9A 1AYKA 1IABA 2W12A 4XM6A 1BSWA 2X3AA 1G05A 4AUOA 3LUMA 1KUHA 1G4KA 5JMYA 3LQBA 2RJQA 4DPEA 3NX7A 2W15A 3N2VA 1CAQA 3OHOA 4IUWA 4H82A 2D1OA 5CXAA 1J7NA 3LE9A 3F17A 3DTIA 4L63A 3ZVSA 1KUFA 1PWQA 1HTDA 3EHXA 3DTKA 3EHYA 4CTHA 1QIAA 1O0TA 5H8XA 2Y6CA 2JT6A 4XM7A 4PKRA 2PJTA 1OS2A 2JNPA 3KEKA 1IACA 1JAQA 2OW0A 4IN9A 2W13A 1G12A 3OHLA 3AIGA 3LEAA 4AIGA 1MMBA 2YB9A 2D1NA 5BPAA 4FXYP 1R1HA 1YQYA 1BIWA 1AKLA 3EDHA 2MLRA 3P24A 3K7LA 2ERQA 2OI0A 3KMCA 3RTSA 2DW0A 4H84A 4J4MA 3O64A 4GWNA 1SATA 1C7KA 4I35A 4DV8A 1JJ9A 4WK7A 3B2ZA 1SU3A 1RMZA 3KRYA 1JH1A 1OM7A 2MZIA 1B8YA 1JIZA 1MMQA 2J0TA 4L7AA 2TCLA 2JIHA 3DNGA 1CQRA 3G5CA 3ZXHA 5LABA 1UTZA 4XM8A 1BKCA 3B8ZA 1Q3AA 2OZRA 2X7MA 5B5PA 4H1QA 3SHIA 2OXUA 3DWBA 4QKZA 5I0LA 1ZS0A 4PKTA 1CK7A 2N8RA 1OM6A 1UEAA 2MLSA 2E2DA 5I4OA 3TS4A 1GKDA 3HBVP 3MA2A 3EDZA 4WF6A 1AF0A 3TVCA 1ASTA 1ROSA 1MMRA 1Y93A 1QJJA 2J83A 4WKIA 2OXZA 2EROA 1HY7A 1OS9A 1EUBA 4GR8A 2I47A 3HBUP 1K7IA 1L6JA 5D1UA 2HU6A 456CA 1KAPP 2JT5A 3F18A 1GKCA 5CUHA 1CGEA 1BZSA 3O2XA 1JK3A 3KHIA 1JAPA 830CA 2W0DA 3TSKA 3HY9A 4H30A 1XFVA 3EDGA 4G0DA 1C3IA 4FU4A 3LGPA 3HYGA 1PWPA 4ZR5A 4AYKA 1XUDA 1K7QA 1K7GA 3LILA 1FLSA 3EWJA 3DSLA 1ZP5A 2DDFA 2WO8A 4HX3A 1ZVXA 1KBCA 3AYKA 3DTEA 2AIGP 2USNA 2MZEA 2DW1A 1GO8P 4ILWD 1GE6A 1ZXVA 4JA1A 4ON1A 1CGFA 3U1RA 3UVCA 5I12A 2ERPA 2Z2DA 1QICA 3F15A 2V4BA 4IJOA 4JIJA 1A86A 1FBLA 1IAGA 4GQLA 3LJTA 2X3BA 2YIGA 3F1AA 3F16A 5BOYA 2OW1A 3HDAP 3LIKA 3ZUKA 1UTTA 2WO9A 3V96B 1BUDA 2OVZA 1HV5A 1CXVA 4H3XA 3LJZA 4L19A 1RM8A 1I1IP 3RTTA 1S4BP 1QIBA 2FV5A 4FXQA 5I2ZA 1R55A 1PWVA 1CGLA 2W14A 1WNIA 1H71P 3DL1A 5CZMA 2K9CA 3KWVC 4PKSA 5D1SA 2Y6DA 1KUKA 3E8RA 4H49A 4L6TA 1R1IA 1XFWA 3I7GA 5D1TA 3AYUA 4JP4A 2OW9A 1XFXA 2YUFA 2X3CA 5L79A 2AYKA 1BKCI 2OXWA 3HY7A 3LK8A 1XFUA 1I76A 3L0TA 2CLTA 1Z3JA 1MNCA 5I3MA 1GE7A 3LUNA 3B92A 2E3XA 4WZVA 4XBHA 1GXDA 3VTGA 1BQQM 3Q2GA 2L0RA 1KUGA 2JSDA 1EB6A 3VI1A 2O36A 3GBOA 1B3DA 1KUIA 1BKCE 3LKAA 2KRJA 1CIZA 3DPFA 3G42A 3WV2A 1JIWP 3CKIA 3LMCA 1JAOA 2OY2A 1ZXCA 4FVLA 4I03A 4JPAA 3ELMA 2POJA 3EDIA 1R1JA 4H76A 2SRTA 3KECA 1IADA 4PKWA 5BOTA 3LQ0A 1SRPA 2DDYA 1ZTQA 4HMAA 1HFCA 3BA0A 1YCMA 2RJPA 2OVXA 2WOAA 3N2UA 1A85A 1MMPA 1Y8JA 4GWMA 1G9KA 1XURA 3F19A 1BM6A 1USNA 4PKQA 1YOUA 1R54A 1EAKA 2XS4A 4EFSA 4Q1LA 4AXQA 1SLNA 1C8TA 1XUCA 1JANA 2QPJA 1ND1A 4WKEA 1UMTA 1D5JA 1D7XA 3LJGA 1OM8A 4XCTA 3WV1A 2OW2A 966CA 1PWUA 4DF9A 4A3WA 5I43A 1D8MA 3Q2HA 3K7NA 4GF1A 5B5OA 1HFSA 3KMEA 4JQGA 3L0VA 3DPEA 1DMTA 1QUAA 3P1VA 3USNA 4PKVA 3KEJA 2XS3A 1GO7P 4H2EA 5D7WA 1XFYA 2DW2A 3LIRA 1UMSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SLM A;  4GUY A;  2A8H A;  1QJI A;  1YP1 A;  4GR3 A;  1IAA A;  4R3V A;  1JKY A;  1FM1 A;  1ATL A;  4DD8 A;  5L7F A;  2K2G A;  1PWW A;  1SMP A;  3HDB A;  3I7I A;  1BUV M;  2OY4 A;  1DTH A;  4A7B A;  2O3E A;  3TT4 A;  1HOV A;  2MZH A;  4GR0 A;  1BQO A;  1GE5 A;  2CKI A;  3WV3 A;  1IAE A;  1XFZ A;  5D2B A;  1OO9 A;  1I73 A;  1OMJ A;  1D8F A;  1Y0V A;  4PKU A;  1O0Q A;  4G9L A;  1G49 A;  5D3C A;  3HB2 P;  2FV9 A;  1AYK A;  1IAB A;  2W12 A;  4XM6 A;  1BSW A;  2X3A A;  1G05 A;  4AUO A;  3LUM A;  1KUH A;  1G4K A;  5JMY A;  3LQB A;  2RJQ A;  4DPE A;  3NX7 A;  2W15 A;  3N2V A;  1CAQ A;  3OHO A;  4IUW A;  4H82 A;  2D1O A;  5CXA A;  1J7N A;  3LE9 A;  3F17 A;  4L63 A;  3ZVS A;  1KUF A;  1PWQ A;  1HTD A;  3EHX A;  3EHY A;  4CTH A;  1QIA A;  1O0T A;  5H8X A;  2Y6C A;  2JT6 A;  4XM7 A;  4PKR A;  2PJT A;  1OS2 A;  2JNP A;  3KEK A;  1IAC A;  1JAQ A;  2OW0 A;  4IN9 A;  2W13 A;  1G12 A;  3OHL A;  3AIG A;  3LEA A;  4AIG A;  1MMB A;  2YB9 A;  2D1N A;  5BPA A;  4FXY P;  1R1H A;  1YQY A;  1BIW A;  1AKL A;  3EDH A;  2MLR A;  3P24 A;  3K7L A;  2ERQ A;  2OI0 A;  3KMC A;  3RTS A;  2DW0 A;  4H84 A;  4J4M A;  3O64 A;  4GWN A;  1SAT A;  1C7K A;  4I35 A;  4DV8 A;  1JJ9 A;  4WK7 A;  3B2Z A;  1SU3 A;  1RMZ A;  3KRY A;  1JH1 A;  1OM7 A;  2MZI A;  1B8Y A;  1JIZ A;  1MMQ A;  2J0T A;  2TCL A;  2JIH A;  3DNG A;  1CQR A;  3G5C A;  3ZXH A;  5LAB A;  1UTZ A;  4XM8 A;  1BKC A;  3B8Z A;  1Q3A A;  2OZR A;  2X7M A;  5B5P A;  4H1Q A;  3SHI A;  2OXU A;  3DWB A;  4QKZ A;  5I0L A;  1ZS0 A;  4PKT A;  1CK7 A;  2N8R A;  1OM6 A;  1UEA A;  2MLS A;  2E2D A;  5I4O A;  3TS4 A;  1GKD A;  3HBV P;  3MA2 A;  3EDZ A;  4WF6 A;  1AF0 A;  3TVC A;  1AST A;  1ROS A;  1MMR A;  1Y93 A;  1QJJ A;  2J83 A;  4WKI A;  2OXZ A;  2ERO A;  1HY7 A;  1OS9 A;  1EUB A;  4GR8 A;  2I47 A;  3HBU P;  1K7I A;  1L6J A;  5D1U A;  2HU6 A;  456C A;  1KAP P;  2JT5 A;  3F18 A;  1GKC A;  5CUH A;  1CGE A;  1BZS A;  3O2X A;  1JK3 A;  3KHI A;  1JAP A;  830C A;  2W0D A;  3TSK A;  3HY9 A;  4H30 A;  1XFV A;  3EDG A;  4G0D A;  1C3I A;  4FU4 A;  3LGP A;  3HYG A;  1PWP A;  4ZR5 A;  4AYK A;  1XUD A;  1K7Q A;  1K7G A;  3LIL A;  1FLS A;  3EWJ A;  3DSL A;  1ZP5 A;  2DDF A;  2WO8 A;  4HX3 A;  1ZVX A;  1KBC A;  3AYK A;  2AIG P;  2USN A;  2MZE A;  2DW1 A;  1GO8 P;  4ILW D;  1GE6 A;  1ZXV A;  4JA1 A;  4ON1 A;  1CGF A;  3U1R A;  3UVC A;  5I12 A;  2ERP A;  2Z2D A;  1QIC A;  3F15 A;  2V4B A;  4IJO A;  4JIJ A;  1A86 A;  1FBL A;  1IAG A;  4GQL A;  3LJT A;  2X3B A;  2YIG A;  3F1A A;  3F16 A;  5BOY A;  2OW1 A;  3HDA P;  3LIK A;  3ZUK A;  1UTT A;  2WO9 A;  3V96 B;  1BUD A;  2OVZ A;  1HV5 A;  1CXV A;  4H3X A;  3LJZ A;  4L19 A;  1RM8 A;  1I1I P;  3RTT A;  1S4B P;  1QIB A;  2FV5 A;  4FXQ A;  5I2Z A;  1R55 A;  1PWV A;  1CGL A;  2W14 A;  1WNI A;  1H71 P;  3DL1 A;  5CZM A;  2K9C A;  3KWV C;  4PKS A;  5D1S A;  2Y6D A;  1KUK A;  3E8R A;  4H49 A;  4L6T A;  1R1I A;  1XFW A;  3I7G A;  5D1T A;  3AYU A;  4JP4 A;  2OW9 A;  1XFX A;  2X3C A;  5L79 A;  2AYK A;  1BKC I;  2OXW A;  3HY7 A;  3LK8 A;  1XFU A;  1I76 A;  3L0T A;  2CLT A;  1Z3J A;  1MNC A;  5I3M A;  1GE7 A;  3LUN A;  3B92 A;  2E3X A;  4WZV A;  4XBH A;  1GXD A;  3VTG A;  1BQQ M;  3Q2G A;  2L0R A;  1KUG A;  2JSD A;  1EB6 A;  3VI1 A;  2O36 A;  3GBO A;  1B3D A;  1KUI A;  1BKC E;  3LKA A;  2KRJ A;  1CIZ A;  3DPF A;  3G42 A;  3WV2 A;  1JIW P;  3CKI A;  3LMC A;  1JAO A;  2OY2 A;  1ZXC A;  4FVL A;  4I03 A;  4JPA A;  3ELM A;  2POJ A;  3EDI A;  1R1J A;  4H76 A;  2SRT A;  3KEC A;  1IAD A;  4PKW A;  5BOT A;  3LQ0 A;  1SRP A;  2DDY A;  1ZTQ A;  4HMA A;  1HFC A;  3BA0 A;  1YCM A;  2RJP A;  2OVX A;  2WOA A;  3N2U A;  1A85 A;  1MMP A;  1Y8J A;  4GWM A;  1G9K A;  1XUR A;  3F19 A;  1BM6 A;  1USN A;  4PKQ A;  1YOU A;  1R54 A;  1EAK A;  2XS4 A;  4EFS A;  4Q1L A;  4AXQ A;  1SLN A;  1C8T A;  1XUC A;  1JAN A;  2QPJ A;  1ND1 A;  4WKE A;  1UMT A;  1D5J A;  1D7X A;  3LJG A;  1OM8 A;  4XCT A;  3WV1 A;  2OW2 A;  966C A;  1PWU A;  4DF9 A;  4A3W A;  5I43 A;  1D8M A;  3Q2H A;  3K7N A;  4GF1 A;  5B5O A;  1HFS A;  3KME A;  4JQG A;  3L0V A;  3DPE A;  1DMT A;  1QUA A;  3P1V A;  3USN A;  4PKV A;  3KEJ A;  2XS3 A;  1GO7 P;  4H2E A;  5D7W A;  1XFY A;  2DW2 A;  3LIR A;  1UMS A; 
#chains in the Genus database with same CATH topology
 1SLM A;  4GUY A;  2A8H A;  1QJI A;  1YP1 A;  4GR3 A;  1IAA A;  4R3V A;  1JKY A;  1FM1 A;  1ATL A;  4DD8 A;  5L7F A;  2K2G A;  1PWW A;  1SMP A;  3HDB A;  3I7I A;  1BUV M;  2OY4 A;  1DTH A;  4A7B A;  2O3E A;  3TT4 A;  1HOV A;  2MZH A;  4GR0 A;  1BQO A;  1GE5 A;  2CKI A;  3WV3 A;  1IAE A;  1XFZ A;  5D2B A;  1OO9 A;  1I73 A;  1OMJ A;  1D8F A;  1Y0V A;  4PKU A;  1O0Q A;  4G9L A;  1G49 A;  5D3C A;  3HB2 P;  2FV9 A;  1AYK A;  1IAB A;  2W12 A;  4XM6 A;  1BSW A;  2X3A A;  1G05 A;  4AUO A;  3LUM A;  1KUH A;  1G4K A;  5JMY A;  3LQB A;  2RJQ A;  4DPE A;  3NX7 A;  2W15 A;  3N2V A;  1CAQ A;  3OHO A;  4IUW A;  4H82 A;  2D1O A;  5CXA A;  1J7N A;  3LE9 A;  3F17 A;  3DTI A;  4L63 A;  3ZVS A;  1KUF A;  1PWQ A;  1HTD A;  3EHX A;  3DTK A;  3EHY A;  4CTH A;  1QIA A;  1O0T A;  5H8X A;  2Y6C A;  2JT6 A;  4XM7 A;  4PKR A;  2PJT A;  1OS2 A;  2JNP A;  3KEK A;  1IAC A;  1JAQ A;  2OW0 A;  4IN9 A;  2W13 A;  1G12 A;  3OHL A;  3AIG A;  3LEA A;  4AIG A;  1MMB A;  2YB9 A;  2D1N A;  5BPA A;  4FXY P;  1R1H A;  1YQY A;  1BIW A;  1AKL A;  3EDH A;  2MLR A;  3P24 A;  3K7L A;  2ERQ A;  2OI0 A;  3KMC A;  3RTS A;  2DW0 A;  4H84 A;  4J4M A;  3O64 A;  4GWN A;  1SAT A;  1C7K A;  4I35 A;  4DV8 A;  1JJ9 A;  4WK7 A;  3B2Z A;  1SU3 A;  1RMZ A;  3KRY A;  1JH1 A;  1OM7 A;  2MZI A;  1B8Y A;  1JIZ A;  1MMQ A;  2J0T A;  4L7A A;  2TCL A;  2JIH A;  3DNG A;  1CQR A;  3G5C A;  3ZXH A;  5LAB A;  1UTZ A;  4XM8 A;  1BKC A;  3B8Z A;  1Q3A A;  2OZR A;  2X7M A;  5B5P A;  4H1Q A;  3SHI A;  2OXU A;  3DWB A;  4QKZ A;  5I0L A;  1ZS0 A;  4PKT A;  1CK7 A;  2N8R A;  1OM6 A;  1UEA A;  2MLS A;  2E2D A;  5I4O A;  3TS4 A;  1GKD A;  1OZ9 A;  3HBV P;  3MA2 A;  3EDZ A;  4WF6 A;  1AF0 A;  3TVC A;  1AST A;  1ROS A;  1MMR A;  1Y93 A;  1QJJ A;  2J83 A;  4WKI A;  2OXZ A;  2ERO A;  1HY7 A;  1OS9 A;  1EUB A;  4GR8 A;  2I47 A;  3HBU P;  1K7I A;  1L6J A;  5D1U A;  2HU6 A;  456C A;  1KAP P;  2JT5 A;  3F18 A;  1GKC A;  5CUH A;  1CGE A;  1BZS A;  3O2X A;  1JK3 A;  3KHI A;  1JAP A;  830C A;  2W0D A;  3TSK A;  3HY9 A;  4H30 A;  1XFV A;  3EDG A;  4G0D A;  1C3I A;  4FU4 A;  3LGP A;  3HYG A;  1PWP A;  4ZR5 A;  4AYK A;  1XUD A;  1K7Q A;  1K7G A;  3LIL A;  1FLS A;  3EWJ A;  3DSL A;  1XAX A;  1ZP5 A;  2DDF A;  2WO8 A;  4HX3 A;  1ZVX A;  1KBC A;  3AYK A;  3DTE A;  2AIG P;  2USN A;  2MZE A;  2DW1 A;  1GO8 P;  4ILW D;  1GE6 A;  1ZXV A;  4JA1 A;  4ON1 A;  1CGF A;  3U1R A;  3UVC A;  5I12 A;  2ERP A;  2Z2D A;  1QIC A;  3F15 A;  2V4B A;  4IJO A;  4JIJ A;  1A86 A;  1FBL A;  1IAG A;  4GQL A;  3LJT A;  2X3B A;  2YIG A;  3F1A A;  3F16 A;  5BOY A;  2OW1 A;  3HDA P;  3LIK A;  3ZUK A;  1UTT A;  2WO9 A;  3V96 B;  1BUD A;  2OVZ A;  1HV5 A;  1CXV A;  4H3X A;  3LJZ A;  4L19 A;  1RM8 A;  1I1I P;  3RTT A;  1S4B P;  1QIB A;  2FV5 A;  4FXQ A;  5I2Z A;  1R55 A;  1PWV A;  1CGL A;  2W14 A;  1WNI A;  1H71 P;  3DL1 A;  5CZM A;  2K9C A;  3KWV C;  4PKS A;  5D1S A;  1XM5 A;  2Y6D A;  1KUK A;  3E8R A;  4H49 A;  4L6T A;  1R1I A;  1XFW A;  3I7G A;  5D1T A;  3AYU A;  4JP4 A;  2OW9 A;  1XFX A;  2YUF A;  2X3C A;  5L79 A;  2AYK A;  1BKC I;  2OXW A;  3HY7 A;  3LK8 A;  1XFU A;  1I76 A;  3L0T A;  2CLT A;  1Z3J A;  1MNC A;  5I3M A;  1GE7 A;  3LUN A;  3B92 A;  2E3X A;  4WZV A;  4XBH A;  1GXD A;  3VTG A;  1BQQ M;  3Q2G A;  2L0R A;  1KUG A;  2JSD A;  1EB6 A;  3VI1 A;  2O36 A;  3GBO A;  1B3D A;  1KUI A;  1BKC E;  3LKA A;  2KRJ A;  1CIZ A;  3DPF A;  3G42 A;  3WV2 A;  1JIW P;  3CKI A;  3LMC A;  1JAO A;  2OY2 A;  1ZXC A;  4FVL A;  1TVI A;  4I03 A;  4JPA A;  3ELM A;  2POJ A;  3EDI A;  1R1J A;  4H76 A;  2SRT A;  3KEC A;  1IAD A;  4PKW A;  5BOT A;  3LQ0 A;  1SRP A;  2DDY A;  1ZTQ A;  4HMA A;  1HFC A;  3BA0 A;  1YCM A;  2RJP A;  2OVX A;  2WOA A;  3N2U A;  1A85 A;  1MMP A;  1Y8J A;  4GWM A;  1G9K A;  1XUR A;  3F19 A;  1BM6 A;  1USN A;  4PKQ A;  1YOU A;  1R54 A;  1EAK A;  2XS4 A;  4EFS A;  4Q1L A;  4AXQ A;  1SLN A;  1C8T A;  1XUC A;  1JAN A;  2QPJ A;  1ND1 A;  4WKE A;  1UMT A;  1D5J A;  1D7X A;  3LJG A;  1OM8 A;  4XCT A;  3WV1 A;  2OW2 A;  966C A;  1PWU A;  4DF9 A;  4A3W A;  5I43 A;  1D8M A;  3Q2H A;  3K7N A;  4GF1 A;  5B5O A;  1HFS A;  3KME A;  4JQG A;  3L0V A;  3DPE A;  1DMT A;  1QUA A;  3P1V A;  3USN A;  4PKV A;  3KEJ A;  2XS3 A;  1GO7 P;  4H2E A;  5D7W A;  1XFY A;  2DW2 A;  3LIR A;  1UMS A; 
#chains in the Genus database with same CATH homology
 1SLM A;  4GUY A;  2A8H A;  1QJI A;  1YP1 A;  4GR3 A;  1IAA A;  4R3V A;  1JKY A;  1FM1 A;  1ATL A;  4DD8 A;  5L7F A;  2K2G A;  1PWW A;  1SMP A;  3HDB A;  3I7I A;  1BUV M;  2OY4 A;  1DTH A;  4A7B A;  2O3E A;  3TT4 A;  1HOV A;  2MZH A;  4GR0 A;  1BQO A;  1GE5 A;  2CKI A;  3WV3 A;  1IAE A;  1XFZ A;  5D2B A;  1OO9 A;  1I73 A;  1OMJ A;  1D8F A;  1Y0V A;  4PKU A;  1O0Q A;  4G9L A;  1G49 A;  5D3C A;  3HB2 P;  2FV9 A;  1AYK A;  1IAB A;  2W12 A;  4XM6 A;  1BSW A;  2X3A A;  1G05 A;  4AUO A;  3LUM A;  1KUH A;  1G4K A;  5JMY A;  3LQB A;  2RJQ A;  4DPE A;  3NX7 A;  2W15 A;  3N2V A;  1CAQ A;  3OHO A;  4IUW A;  4H82 A;  2D1O A;  5CXA A;  1J7N A;  3LE9 A;  3F17 A;  3DTI A;  4L63 A;  3ZVS A;  1KUF A;  1PWQ A;  1HTD A;  3EHX A;  3DTK A;  3EHY A;  4CTH A;  1QIA A;  1O0T A;  5H8X A;  2Y6C A;  2JT6 A;  4XM7 A;  4PKR A;  2PJT A;  1OS2 A;  2JNP A;  3KEK A;  1IAC A;  1JAQ A;  2OW0 A;  4IN9 A;  2W13 A;  1G12 A;  3OHL A;  3AIG A;  3LEA A;  4AIG A;  1MMB A;  2YB9 A;  2D1N A;  5BPA A;  4FXY P;  1R1H A;  1YQY A;  1BIW A;  1AKL A;  3EDH A;  2MLR A;  3P24 A;  3K7L A;  2ERQ A;  2OI0 A;  3KMC A;  3RTS A;  2DW0 A;  4H84 A;  4J4M A;  3O64 A;  4GWN A;  1SAT A;  1C7K A;  4I35 A;  4DV8 A;  1JJ9 A;  4WK7 A;  3B2Z A;  1SU3 A;  1RMZ A;  3KRY A;  1JH1 A;  1OM7 A;  2MZI A;  1B8Y A;  1JIZ A;  1MMQ A;  2J0T A;  4L7A A;  2TCL A;  2JIH A;  3DNG A;  1CQR A;  3G5C A;  3ZXH A;  5LAB A;  1UTZ A;  4XM8 A;  1BKC A;  3B8Z A;  1Q3A A;  2OZR A;  2X7M A;  5B5P A;  4H1Q A;  3SHI A;  2OXU A;  3DWB A;  4QKZ A;  5I0L A;  1ZS0 A;  4PKT A;  1CK7 A;  2N8R A;  1OM6 A;  1UEA A;  2MLS A;  2E2D A;  5I4O A;  3TS4 A;  1GKD A;  3HBV P;  3MA2 A;  3EDZ A;  4WF6 A;  1AF0 A;  3TVC A;  1AST A;  1ROS A;  1MMR A;  1Y93 A;  1QJJ A;  2J83 A;  4WKI A;  2OXZ A;  2ERO A;  1HY7 A;  1OS9 A;  1EUB A;  4GR8 A;  2I47 A;  3HBU P;  1K7I A;  1L6J A;  5D1U A;  2HU6 A;  456C A;  1KAP P;  2JT5 A;  3F18 A;  1GKC A;  5CUH A;  1CGE A;  1BZS A;  3O2X A;  1JK3 A;  3KHI A;  1JAP A;  830C A;  2W0D A;  3TSK A;  3HY9 A;  4H30 A;  1XFV A;  3EDG A;  4G0D A;  1C3I A;  4FU4 A;  3LGP A;  3HYG A;  1PWP A;  4ZR5 A;  4AYK A;  1XUD A;  1K7Q A;  1K7G A;  3LIL A;  1FLS A;  3EWJ A;  3DSL A;  1ZP5 A;  2DDF A;  2WO8 A;  4HX3 A;  1ZVX A;  1KBC A;  3AYK A;  3DTE A;  2AIG P;  2USN A;  2MZE A;  2DW1 A;  1GO8 P;  4ILW D;  1GE6 A;  1ZXV A;  4JA1 A;  4ON1 A;  1CGF A;  3U1R A;  3UVC A;  5I12 A;  2ERP A;  2Z2D A;  1QIC A;  3F15 A;  2V4B A;  4IJO A;  4JIJ A;  1A86 A;  1FBL A;  1IAG A;  4GQL A;  3LJT A;  2X3B A;  2YIG A;  3F1A A;  3F16 A;  5BOY A;  2OW1 A;  3HDA P;  3LIK A;  3ZUK A;  1UTT A;  2WO9 A;  3V96 B;  1BUD A;  2OVZ A;  1HV5 A;  1CXV A;  4H3X A;  3LJZ A;  4L19 A;  1RM8 A;  1I1I P;  3RTT A;  1S4B P;  1QIB A;  2FV5 A;  4FXQ A;  5I2Z A;  1R55 A;  1PWV A;  1CGL A;  2W14 A;  1WNI A;  1H71 P;  3DL1 A;  5CZM A;  2K9C A;  3KWV C;  4PKS A;  5D1S A;  2Y6D A;  1KUK A;  3E8R A;  4H49 A;  4L6T A;  1R1I A;  1XFW A;  3I7G A;  5D1T A;  3AYU A;  4JP4 A;  2OW9 A;  1XFX A;  2YUF A;  2X3C A;  5L79 A;  2AYK A;  1BKC I;  2OXW A;  3HY7 A;  3LK8 A;  1XFU A;  1I76 A;  3L0T A;  2CLT A;  1Z3J A;  1MNC A;  5I3M A;  1GE7 A;  3LUN A;  3B92 A;  2E3X A;  4WZV A;  4XBH A;  1GXD A;  3VTG A;  1BQQ M;  3Q2G A;  2L0R A;  1KUG A;  2JSD A;  1EB6 A;  3VI1 A;  2O36 A;  3GBO A;  1B3D A;  1KUI A;  1BKC E;  3LKA A;  2KRJ A;  1CIZ A;  3DPF A;  3G42 A;  3WV2 A;  1JIW P;  3CKI A;  3LMC A;  1JAO A;  2OY2 A;  1ZXC A;  4FVL A;  4I03 A;  4JPA A;  3ELM A;  2POJ A;  3EDI A;  1R1J A;  4H76 A;  2SRT A;  3KEC A;  1IAD A;  4PKW A;  5BOT A;  3LQ0 A;  1SRP A;  2DDY A;  1ZTQ A;  4HMA A;  1HFC A;  3BA0 A;  1YCM A;  2RJP A;  2OVX A;  2WOA A;  3N2U A;  1A85 A;  1MMP A;  1Y8J A;  4GWM A;  1G9K A;  1XUR A;  3F19 A;  1BM6 A;  1USN A;  4PKQ A;  1YOU A;  1R54 A;  1EAK A;  2XS4 A;  4EFS A;  4Q1L A;  4AXQ A;  1SLN A;  1C8T A;  1XUC A;  1JAN A;  2QPJ A;  1ND1 A;  4WKE A;  1UMT A;  1D5J A;  1D7X A;  3LJG A;  1OM8 A;  4XCT A;  3WV1 A;  2OW2 A;  966C A;  1PWU A;  4DF9 A;  4A3W A;  5I43 A;  1D8M A;  3Q2H A;  3K7N A;  4GF1 A;  5B5O A;  1HFS A;  3KME A;  4JQG A;  3L0V A;  3DPE A;  1DMT A;  1QUA A;  3P1V A;  3USN A;  4PKV A;  3KEJ A;  2XS3 A;  1GO7 P;  4H2E A;  5D7W A;  1XFY A;  2DW2 A;  3LIR A;  1UMS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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