1ROSA

Crystal structure of mmp-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)ethyl-4-(4-ethoxy[1,1-biphenyl]-4-yl)-4-oxobutanoic acid
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
159
structure length
159
Chain Sequence
GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Macrophage metalloelastase
total genus 43
structure length 159
sequence length 159
chains with identical sequence B
ec nomenclature ec 3.4.24.65: Macrophage elastase.
pdb deposition date 2003-12-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00413 Peptidase_M10 Matrixin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 1rosA00
1ROSA 1IAEA 1SRPA 4GWMA 3HBVP 2OW2A 4A7BA 1MMRA 1YOUA 3HY9A 3LEAA 1KUIA 3OHLA 2POJA 1EUBA 1C8TA 4GR0A 1XURA 4XM6A 4GQLA 3KMEA 4IUWA 3ELMA 2OI0A 3LK8A 966CA 3Q2GA 2XS3A 3P24A 1IACA 1GO8P 1XUCA 3N2UA 1G4KA 3L0TA 1JK3A 2K2GA 1ND1A 3F15A 4H1QA 4J4MA 1SLMA 3OHOA 2JIHA 3L0VA 2ERPA 2D1OA 4CTHA 1KUFA 1QJJA 2OY4A 1MMQA 5CXAA 3HY7A 1HY7A 1JH1A 1KAPP 1Q3AA 1D8FA 1PWQA 1KUHA 3TS4A 1BQOA 5JMYA 3O64A 4XBHA 4I03A 3EDIA 4GWNA 5D1SA 2X3BA 5D1UA 1ZS0A 2AIGP 5I43A 456CA 2QPJA 1SATA 1PWWA 1R54A 1IAAA 2OY2A 4ILWD 3DNGA 4WF6A 2MZHA 3GBOA 4L6TA 1ZXCA 3RTSA 2Y6DA 3TT4A 1BSWA 4HMAA 3EDGA 3HDBA 3MA2A 4JIJA 2L0RA 3I7IA 5BPAA 1GXDA 3LILA 5I3MA 1RM8A 3LQBA 3WV1A 1EB6A 1YP1A 4DPEA 5I12A 1ZTQA 1HV5A 1GKDA 1IAGA 1D8MA 1GE7A 4IJOA 1PWPA 4WKIA 2DW0A 5D1TA 4WKEA 2USNA 1CK7A 3KRYA 2FV5A 1FBLA 1BM6A 4FXYP 2HU6A 1Y8JA 4ON1A 2MLRA 3DWBA 1BKCI 3G42A 4H49A 3SHIA 2JT5A 4XM7A 3WV2A 5LABA 3Q2HA 4FU4A 2OZRA 3LJGA 1B8YA 4AXQA 1CGEA 1GKCA 1CGLA 1H71P 4A3WA 1MNCA 1O0QA 2KRJA 1AF0A 1IADA 1UTZA 2J83A 3EDZA 3K7NA 3O2XA 3EDHA 1G49A 3AIGA 1JIZA 2EROA 5I2ZA 1O0TA 1OMJA 2W14A 4DF9A 4AIGA 3F18A 2JNPA 4WZVA 1CAQA 1G9KA 3LKAA 2O3EA 3NX7A 1KBCA 4DD8A 1JJ9A 4L19A 3ZXHA 1OM8A 3EHYA 2DDYA 4Q1LA 1I73A 1XFXA 4H3XA 1ZP5A 1C3IA 1JAQA 2FV9A 4EFSA 1K7GA 2D1NA 1BUVM 3LUMA 4PKWA 2V4BA 1QUAA 1YCMA 3DL1A 1Y0VA 4H76A 1XFUA 1UMSA 1GO7P 5BOTA 3N2VA 1BQQM 1XUDA 4FVLA 2E2DA 1QJIA 4QKZA 2I47A 2RJQA 3F1AA 1USNA 3F16A 4PKTA 3P1VA 4H84A 4ZR5A 3V96B 2AYKA 3LMCA 1QIBA 1ASTA 4PKUA 1CIZA 5L7FA 3EHXA 1UTTA 3WV3A 2DW1A 1SU3A 2Y6CA 4JA1A 4JQGA 5BOYA 1DMTA 3LIKA 2TCLA 1BZSA 1BKCE 1R1JA 3TSKA 3LUNA 5H8XA 2W12A 2A8HA 3LQ0A 1R1HA 4AYKA 2OW0A 1CGFA 3B8ZA 4XM8A 5B5OA 3F19A 2OW1A 1XFZA 2CLTA 3KWVC 4HX3A 1ZXVA 2X3AA 1HTDA 1QICA 2MZIA 1PWVA 1AYKA 4XCTA 1GE5A 2Z2DA 3I7GA 4GF1A 3TVCA 3E8RA 5L79A 4H2EA 4JPAA 1I1IP 3DPFA 3ZUKA 3U1RA 1Z3JA 1ZVXA 1AKLA 3VI1A 5D7WA 1JAPA 1SMPA 1R1IA 1A85A 3HYGA 4H30A 4WK7A 1JKYA 3HB2P 1FM1A 3LIRA 1OS9A 4DV8A 2RJPA 1K7IA 4PKRA 2PJTA 2ERQA 1CQRA 1XFWA 3LJZA 1FLSA 1HFCA 2OXUA 1YQYA 1JIWP 1RMZA 1UMTA 1G12A 3G5CA 2CKIA 4PKSA 1K7QA 1BKCA 3CKIA 4JP4A 3UVCA 3B92A 2W0DA 5D3CA 1OO9A 2DDFA 1Y93A 3AYKA 3DPEA 2K9CA 2OW9A 2W13A 1D7XA 3BA0A 4I35A 1GE6A 1D5JA 1QIAA 3F17A 1L6JA 3KEJA 2OVZA 3RTTA 3DSLA 2YIGA 1XFYA 3KMCA 2OXWA 1I76A 2O36A 1HOVA 2N8RA 3KHIA 5I0LA 3USNA 3KECA 1ATLA 1JANA 1DTHA 3LJTA 3VTGA 3HDAP 3B2ZA 5D2BA 2OXZA 1KUKA 4H82A 2WOAA 1XFVA 4GR3A 3AYUA 2MZEA 4PKQA 2E3XA 1CXVA 1PWUA 4GUYA 4PKVA 1R55A 1MMPA 1IABA 1MMBA 1B3DA 4G0DA 5CUHA 2J0TA 2SRTA 5I4OA 1BIWA 2X3CA 3EWJA 1A86A 1OM6A 1BUDA 2XS4A 3LE9A 1SLNA 1JAOA 3ZVSA 2W15A 3KEKA 830CA 1EAKA 2WO9A 1UEAA 4IN9A 4AUOA 3HBUP 4R3VA 5B5PA 1J7NA 2DW2A 1KUGA 1OS2A 1C7KA 3LGPA 4G9LA 1OM7A 4GR8A 1G05A 3K7LA 2JSDA 2YB9A 1S4BP 5CZMA 2OVXA 4L63A 2JT6A 2X7MA 4FXQA 1HFSA 2MLSA 2WO8A 1WNIA
chains in the Genus database with same CATH superfamily
1ROSA 1IAEA 1SRPA 4GWMA 3HBVP 2OW2A 4A7BA 1MMRA 3DTIA 1YOUA 3HY9A 3LEAA 1KUIA 3OHLA 2POJA 1EUBA 1C8TA 4GR0A 1XURA 4XM6A 4GQLA 3KMEA 4IUWA 3ELMA 2OI0A 3LK8A 966CA 3Q2GA 2XS3A 3P24A 1IACA 1GO8P 1XUCA 3N2UA 1G4KA 3L0TA 1JK3A 2K2GA 1ND1A 3F15A 4H1QA 4J4MA 1SLMA 3OHOA 2JIHA 3L0VA 2ERPA 2D1OA 4CTHA 1KUFA 1QJJA 2OY4A 1MMQA 1TVIA 5CXAA 3HY7A 1HY7A 1JH1A 1KAPP 1Q3AA 1D8FA 1PWQA 1KUHA 3TS4A 1BQOA 1XAXA 5JMYA 3O64A 4XBHA 4I03A 3EDIA 4GWNA 5D1SA 2X3BA 5D1UA 1ZS0A 2AIGP 5I43A 456CA 2QPJA 1SATA 1PWWA 1R54A 1IAAA 2OY2A 4ILWD 3DNGA 4WF6A 2MZHA 3GBOA 4L6TA 1ZXCA 3RTSA 2Y6DA 3TT4A 1BSWA 4HMAA 3EDGA 3HDBA 3MA2A 4JIJA 2L0RA 3I7IA 5BPAA 1GXDA 3LILA 5I3MA 1RM8A 3LQBA 3WV1A 1EB6A 1YP1A 4DPEA 5I12A 1ZTQA 1HV5A 1OZ9A 1GKDA 1IAGA 1D8MA 1GE7A 4IJOA 1PWPA 4WKIA 2DW0A 5D1TA 4WKEA 2USNA 1CK7A 3KRYA 2FV5A 1FBLA 1BM6A 4FXYP 2HU6A 1Y8JA 4ON1A 2MLRA 3DWBA 1BKCI 3G42A 4H49A 3SHIA 2JT5A 4XM7A 3WV2A 5LABA 3Q2HA 4FU4A 2OZRA 3LJGA 1B8YA 4AXQA 1CGEA 1GKCA 1CGLA 1H71P 4A3WA 1MNCA 1O0QA 2KRJA 1AF0A 1IADA 1UTZA 2J83A 3EDZA 3K7NA 3O2XA 3EDHA 1G49A 3AIGA 1JIZA 2EROA 5I2ZA 1O0TA 1OMJA 2W14A 4DF9A 4AIGA 3F18A 2JNPA 4WZVA 1CAQA 1G9KA 3LKAA 2O3EA 3NX7A 1KBCA 4DD8A 1JJ9A 4L19A 3ZXHA 1OM8A 3EHYA 2DDYA 4Q1LA 1I73A 1XFXA 4H3XA 1ZP5A 1C3IA 1JAQA 2FV9A 4EFSA 1K7GA 2D1NA 1BUVM 3LUMA 4PKWA 2V4BA 1QUAA 1YCMA 3DL1A 1Y0VA 4H76A 1XFUA 1UMSA 1GO7P 5BOTA 3N2VA 1BQQM 1XUDA 4FVLA 2E2DA 1QJIA 4QKZA 2I47A 2RJQA 3F1AA 1USNA 3F16A 4PKTA 3P1VA 4H84A 4ZR5A 3V96B 2AYKA 3LMCA 1QIBA 1ASTA 4PKUA 1CIZA 5L7FA 3EHXA 1UTTA 3WV3A 2DW1A 1SU3A 2Y6CA 4JA1A 4JQGA 5BOYA 1DMTA 3LIKA 3DTKA 4L7AA 2TCLA 1BZSA 1BKCE 1R1JA 3TSKA 2YUFA 3LUNA 5H8XA 2W12A 2A8HA 3LQ0A 1R1HA 4AYKA 2OW0A 1CGFA 3B8ZA 4XM8A 5B5OA 3F19A 2OW1A 1XFZA 2CLTA 3KWVC 4HX3A 3DTEA 1ZXVA 2X3AA 1HTDA 1QICA 2MZIA 1PWVA 1AYKA 4XCTA 1GE5A 2Z2DA 3I7GA 4GF1A 3TVCA 3E8RA 5L79A 4H2EA 4JPAA 1I1IP 3DPFA 3ZUKA 3U1RA 1Z3JA 1ZVXA 1AKLA 3VI1A 5D7WA 1JAPA 1SMPA 1R1IA 1A85A 3HYGA 4H30A 4WK7A 1JKYA 3HB2P 1FM1A 3LIRA 1OS9A 4DV8A 2RJPA 1K7IA 4PKRA 2PJTA 2ERQA 1CQRA 1XFWA 1FLSA 1HFCA 3LJZA 2OXUA 1YQYA 1JIWP 1RMZA 1UMTA 1G12A 3G5CA 2CKIA 4PKSA 1K7QA 1BKCA 3CKIA 4JP4A 3UVCA 3B92A 2W0DA 5D3CA 1OO9A 2DDFA 1Y93A 3AYKA 3DPEA 2K9CA 2OW9A 2W13A 1D7XA 3BA0A 4I35A 1GE6A 1D5JA 1QIAA 3F17A 1L6JA 3KEJA 2OVZA 3RTTA 3DSLA 2YIGA 1XFYA 3KMCA 2OXWA 1I76A 2O36A 1HOVA 2N8RA 3KHIA 5I0LA 3USNA 3KECA 1ATLA 1JANA 1DTHA 3LJTA 3VTGA 3HDAP 3B2ZA 5D2BA 2OXZA 1KUKA 4H82A 2WOAA 1XFVA 4GR3A 3AYUA 2MZEA 4PKQA 2E3XA 1CXVA 1PWUA 4GUYA 4PKVA 1R55A 1MMPA 1IABA 1MMBA 1B3DA 4G0DA 5CUHA 2J0TA 2SRTA 5I4OA 1BIWA 2X3CA 3EWJA 1A86A 1OM6A 1BUDA 2XS4A 3LE9A 1SLNA 1JAOA 3ZVSA 2W15A 3KEKA 830CA 1EAKA 2WO9A 1UEAA 4IN9A 4AUOA 3HBUP 4R3VA 5B5PA 1J7NA 2DW2A 1KUGA 1OS2A 1C7KA 3LGPA 4G9LA 1OM7A 4GR8A 1G05A 3K7LA 2JSDA 2YB9A 1S4BP 5CZMA 2OVXA 4L63A 2JT6A 2X7MA 4FXQA 1HFSA 1XM5A 2MLSA 2WO8A 1WNIA
chains in the Genus database with same CATH topology
1ROSA 1IAEA 1SRPA 4GWMA 3HBVP 2OW2A 4A7BA 1MMRA 3DTIA 1YOUA 3HY9A 3LEAA 1KUIA 3OHLA 2POJA 1EUBA 1C8TA 4GR0A 1XURA 4XM6A 4GQLA 3KMEA 4IUWA 3ELMA 2OI0A 3LK8A 966CA 3Q2GA 2XS3A 3P24A 1IACA 1GO8P 1XUCA 3N2UA 1G4KA 3L0TA 1JK3A 2K2GA 1ND1A 3F15A 4H1QA 4J4MA 1SLMA 3OHOA 2JIHA 3L0VA 2ERPA 2D1OA 4CTHA 1KUFA 1QJJA 2OY4A 1MMQA 5CXAA 3HY7A 1HY7A 1JH1A 1KAPP 1Q3AA 1D8FA 1PWQA 1KUHA 3TS4A 1BQOA 5JMYA 3O64A 4XBHA 4I03A 3EDIA 4GWNA 5D1SA 2X3BA 5D1UA 1ZS0A 2AIGP 5I43A 456CA 2QPJA 1SATA 1PWWA 1R54A 1IAAA 2OY2A 4ILWD 3DNGA 4WF6A 2MZHA 3GBOA 4L6TA 1ZXCA 3RTSA 2Y6DA 3TT4A 1BSWA 4HMAA 3EDGA 3HDBA 3MA2A 4JIJA 2L0RA 3I7IA 5BPAA 1GXDA 3LILA 5I3MA 1RM8A 3LQBA 3WV1A 1EB6A 1YP1A 4DPEA 5I12A 1ZTQA 1HV5A 1GKDA 1IAGA 1D8MA 1GE7A 4IJOA 1PWPA 4WKIA 2DW0A 5D1TA 4WKEA 2USNA 1CK7A 3KRYA 2FV5A 1FBLA 1BM6A 4FXYP 2HU6A 1Y8JA 4ON1A 2MLRA 3DWBA 1BKCI 3G42A 4H49A 3SHIA 2JT5A 4XM7A 3WV2A 5LABA 3Q2HA 4FU4A 2OZRA 3LJGA 1B8YA 4AXQA 1CGEA 1GKCA 1CGLA 1H71P 4A3WA 1MNCA 1O0QA 2KRJA 1AF0A 1IADA 1UTZA 2J83A 3EDZA 3K7NA 3O2XA 3EDHA 1G49A 3AIGA 1JIZA 2EROA 5I2ZA 1O0TA 1OMJA 2W14A 4DF9A 4AIGA 3F18A 2JNPA 4WZVA 1CAQA 1G9KA 3LKAA 2O3EA 3NX7A 1KBCA 4DD8A 1JJ9A 4L19A 3ZXHA 1OM8A 3EHYA 2DDYA 4Q1LA 1I73A 1XFXA 4H3XA 1ZP5A 1C3IA 1JAQA 2FV9A 4EFSA 1K7GA 2D1NA 1BUVM 3LUMA 4PKWA 2V4BA 1QUAA 1YCMA 3DL1A 1Y0VA 4H76A 1XFUA 1UMSA 1GO7P 5BOTA 3N2VA 1BQQM 1XUDA 4FVLA 2E2DA 1QJIA 4QKZA 2I47A 2RJQA 3F1AA 1USNA 3F16A 4PKTA 3P1VA 4H84A 4ZR5A 3V96B 2AYKA 3LMCA 1QIBA 1ASTA 4PKUA 1CIZA 5L7FA 3EHXA 1UTTA 3WV3A 2DW1A 1SU3A 2Y6CA 4JA1A 4JQGA 5BOYA 1DMTA 3LIKA 3DTKA 4L7AA 2TCLA 1BZSA 1BKCE 1R1JA 3TSKA 2YUFA 3LUNA 5H8XA 2W12A 2A8HA 3LQ0A 1R1HA 4AYKA 2OW0A 1CGFA 3B8ZA 4XM8A 5B5OA 3F19A 2OW1A 1XFZA 2CLTA 3KWVC 4HX3A 3DTEA 1ZXVA 2X3AA 1HTDA 1QICA 2MZIA 1PWVA 1AYKA 4XCTA 1GE5A 2Z2DA 3I7GA 4GF1A 3TVCA 3E8RA 5L79A 4H2EA 4JPAA 1I1IP 3DPFA 3ZUKA 3U1RA 1Z3JA 1ZVXA 1AKLA 3VI1A 5D7WA 1JAPA 1SMPA 1R1IA 1A85A 3HYGA 4H30A 4WK7A 1JKYA 3HB2P 1FM1A 3LIRA 1OS9A 4DV8A 2RJPA 1K7IA 4PKRA 2PJTA 2ERQA 1CQRA 1XFWA 3LJZA 1FLSA 1HFCA 2OXUA 1YQYA 1JIWP 1RMZA 1UMTA 1G12A 3G5CA 2CKIA 4PKSA 1K7QA 1BKCA 3CKIA 4JP4A 3UVCA 3B92A 2W0DA 5D3CA 1OO9A 2DDFA 1Y93A 3AYKA 3DPEA 2K9CA 2OW9A 2W13A 1D7XA 3BA0A 4I35A 1GE6A 1D5JA 1QIAA 3F17A 1L6JA 3KEJA 2OVZA 3RTTA 3DSLA 2YIGA 1XFYA 3KMCA 2OXWA 1I76A 2O36A 1HOVA 2N8RA 3KHIA 5I0LA 3USNA 3KECA 1ATLA 1JANA 1DTHA 3LJTA 3VTGA 3HDAP 3B2ZA 5D2BA 2OXZA 1KUKA 4H82A 2WOAA 1XFVA 4GR3A 3AYUA 2MZEA 4PKQA 2E3XA 1CXVA 1PWUA 4GUYA 4PKVA 1R55A 1MMPA 1IABA 1MMBA 1B3DA 4G0DA 5CUHA 2J0TA 2SRTA 5I4OA 1BIWA 2X3CA 3EWJA 1A86A 1OM6A 1BUDA 2XS4A 3LE9A 1SLNA 1JAOA 3ZVSA 2W15A 3KEKA 830CA 1EAKA 2WO9A 1UEAA 4IN9A 4AUOA 3HBUP 4R3VA 5B5PA 1J7NA 2DW2A 1KUGA 1OS2A 1C7KA 3LGPA 4G9LA 1OM7A 4GR8A 1G05A 3K7LA 2JSDA 2YB9A 1S4BP 5CZMA 2OVXA 4L63A 2JT6A 2X7MA 4FXQA 1HFSA 2MLSA 2WO8A 1WNIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ROS A;  1IAE A;  1SRP A;  4GWM A;  3HBV P;  2OW2 A;  4A7B A;  1MMR A;  1YOU A;  3HY9 A;  3LEA A;  1KUI A;  3OHL A;  2POJ A;  1EUB A;  1C8T A;  4GR0 A;  1XUR A;  4XM6 A;  4GQL A;  3KME A;  4IUW A;  3ELM A;  2OI0 A;  3LK8 A;  966C A;  3Q2G A;  2XS3 A;  3P24 A;  1IAC A;  1GO8 P;  1XUC A;  3N2U A;  1G4K A;  3L0T A;  1JK3 A;  2K2G A;  1ND1 A;  3F15 A;  4H1Q A;  4J4M A;  1SLM A;  3OHO A;  2JIH A;  3L0V A;  2ERP A;  2D1O A;  4CTH A;  1KUF A;  1QJJ A;  2OY4 A;  1MMQ A;  5CXA A;  3HY7 A;  1HY7 A;  1JH1 A;  1KAP P;  1Q3A A;  1D8F A;  1PWQ A;  1KUH A;  3TS4 A;  1BQO A;  5JMY A;  3O64 A;  4XBH A;  4I03 A;  3EDI A;  4GWN A;  5D1S A;  2X3B A;  5D1U A;  1ZS0 A;  2AIG P;  5I43 A;  456C A;  2QPJ A;  1SAT A;  1PWW A;  1R54 A;  1IAA A;  2OY2 A;  4ILW D;  3DNG A;  4WF6 A;  2MZH A;  3GBO A;  4L6T A;  1ZXC A;  3RTS A;  2Y6D A;  3TT4 A;  1BSW A;  4HMA A;  3EDG A;  3HDB A;  3MA2 A;  4JIJ A;  2L0R A;  3I7I A;  5BPA A;  1GXD A;  3LIL A;  5I3M A;  1RM8 A;  3LQB A;  3WV1 A;  1EB6 A;  1YP1 A;  4DPE A;  5I12 A;  1ZTQ A;  1HV5 A;  1GKD A;  1IAG A;  1D8M A;  1GE7 A;  4IJO A;  1PWP A;  4WKI A;  2DW0 A;  5D1T A;  4WKE A;  2USN A;  1CK7 A;  3KRY A;  2FV5 A;  1FBL A;  1BM6 A;  4FXY P;  2HU6 A;  1Y8J A;  4ON1 A;  2MLR A;  3DWB A;  1BKC I;  3G42 A;  4H49 A;  3SHI A;  2JT5 A;  4XM7 A;  3WV2 A;  5LAB A;  3Q2H A;  4FU4 A;  2OZR A;  3LJG A;  1B8Y A;  4AXQ A;  1CGE A;  1GKC A;  1CGL A;  1H71 P;  4A3W A;  1MNC A;  1O0Q A;  2KRJ A;  1AF0 A;  1IAD A;  1UTZ A;  2J83 A;  3EDZ A;  3K7N A;  3O2X A;  3EDH A;  1G49 A;  3AIG A;  1JIZ A;  2ERO A;  5I2Z A;  1O0T A;  1OMJ A;  2W14 A;  4DF9 A;  4AIG A;  3F18 A;  2JNP A;  4WZV A;  1CAQ A;  1G9K A;  3LKA A;  2O3E A;  3NX7 A;  1KBC A;  4DD8 A;  1JJ9 A;  4L19 A;  3ZXH A;  1OM8 A;  3EHY A;  2DDY A;  4Q1L A;  1I73 A;  1XFX A;  4H3X A;  1ZP5 A;  1C3I A;  1JAQ A;  2FV9 A;  4EFS A;  1K7G A;  2D1N A;  1BUV M;  3LUM A;  4PKW A;  2V4B A;  1QUA A;  1YCM A;  3DL1 A;  1Y0V A;  4H76 A;  1XFU A;  1UMS A;  1GO7 P;  5BOT A;  3N2V A;  1BQQ M;  1XUD A;  4FVL A;  2E2D A;  1QJI A;  4QKZ A;  2I47 A;  2RJQ A;  3F1A A;  1USN A;  3F16 A;  4PKT A;  3P1V A;  4H84 A;  4ZR5 A;  3V96 B;  2AYK A;  3LMC A;  1QIB A;  1AST A;  4PKU A;  1CIZ A;  5L7F A;  3EHX A;  1UTT A;  3WV3 A;  2DW1 A;  1SU3 A;  2Y6C A;  4JA1 A;  4JQG A;  5BOY A;  1DMT A;  3LIK A;  2TCL A;  1BZS A;  1BKC E;  1R1J A;  3TSK A;  3LUN A;  5H8X A;  2W12 A;  2A8H A;  3LQ0 A;  1R1H A;  4AYK A;  2OW0 A;  1CGF A;  3B8Z A;  4XM8 A;  5B5O A;  3F19 A;  2OW1 A;  1XFZ A;  2CLT A;  3KWV C;  4HX3 A;  1ZXV A;  2X3A A;  1HTD A;  1QIC A;  2MZI A;  1PWV A;  1AYK A;  4XCT A;  1GE5 A;  2Z2D A;  3I7G A;  4GF1 A;  3TVC A;  3E8R A;  5L79 A;  4H2E A;  4JPA A;  1I1I P;  3DPF A;  3ZUK A;  3U1R A;  1Z3J A;  1ZVX A;  1AKL A;  3VI1 A;  5D7W A;  1JAP A;  1SMP A;  1R1I A;  1A85 A;  3HYG A;  4H30 A;  4WK7 A;  1JKY A;  3HB2 P;  1FM1 A;  3LIR A;  1OS9 A;  4DV8 A;  2RJP A;  1K7I A;  4PKR A;  2PJT A;  2ERQ A;  1CQR A;  1XFW A;  3LJZ A;  1FLS A;  1HFC A;  2OXU A;  1YQY A;  1JIW P;  1RMZ A;  1UMT A;  1G12 A;  3G5C A;  2CKI A;  4PKS A;  1K7Q A;  1BKC A;  3CKI A;  4JP4 A;  3UVC A;  3B92 A;  2W0D A;  5D3C A;  1OO9 A;  2DDF A;  1Y93 A;  3AYK A;  3DPE A;  2K9C A;  2OW9 A;  2W13 A;  1D7X A;  3BA0 A;  4I35 A;  1GE6 A;  1D5J A;  1QIA A;  3F17 A;  1L6J A;  3KEJ A;  2OVZ A;  3RTT A;  3DSL A;  2YIG A;  1XFY A;  3KMC A;  2OXW A;  1I76 A;  2O36 A;  1HOV A;  2N8R A;  3KHI A;  5I0L A;  3USN A;  3KEC A;  1ATL A;  1JAN A;  1DTH A;  3LJT A;  3VTG A;  3HDA P;  3B2Z A;  5D2B A;  2OXZ A;  1KUK A;  4H82 A;  2WOA A;  1XFV A;  4GR3 A;  3AYU A;  2MZE A;  4PKQ A;  2E3X A;  1CXV A;  1PWU A;  4GUY A;  4PKV A;  1R55 A;  1MMP A;  1IAB A;  1MMB A;  1B3D A;  4G0D A;  5CUH A;  2J0T A;  2SRT A;  5I4O A;  1BIW A;  2X3C A;  3EWJ A;  1A86 A;  1OM6 A;  1BUD A;  2XS4 A;  3LE9 A;  1SLN A;  1JAO A;  3ZVS A;  2W15 A;  3KEK A;  830C A;  1EAK A;  2WO9 A;  1UEA A;  4IN9 A;  4AUO A;  3HBU P;  4R3V A;  5B5P A;  1J7N A;  2DW2 A;  1KUG A;  1OS2 A;  1C7K A;  3LGP A;  4G9L A;  1OM7 A;  4GR8 A;  1G05 A;  3K7L A;  2JSD A;  2YB9 A;  1S4B P;  5CZM A;  2OVX A;  4L63 A;  2JT6 A;  2X7M A;  4FXQ A;  1HFS A;  2MLS A;  2WO8 A;  1WNI A; 
#chains in the Genus database with same CATH topology
 1ROS A;  1IAE A;  1SRP A;  4GWM A;  3HBV P;  2OW2 A;  4A7B A;  1MMR A;  3DTI A;  1YOU A;  3HY9 A;  3LEA A;  1KUI A;  3OHL A;  2POJ A;  1EUB A;  1C8T A;  4GR0 A;  1XUR A;  4XM6 A;  4GQL A;  3KME A;  4IUW A;  3ELM A;  2OI0 A;  3LK8 A;  966C A;  3Q2G A;  2XS3 A;  3P24 A;  1IAC A;  1GO8 P;  1XUC A;  3N2U A;  1G4K A;  3L0T A;  1JK3 A;  2K2G A;  1ND1 A;  3F15 A;  4H1Q A;  4J4M A;  1SLM A;  3OHO A;  2JIH A;  3L0V A;  2ERP A;  2D1O A;  4CTH A;  1KUF A;  1QJJ A;  2OY4 A;  1MMQ A;  1TVI A;  5CXA A;  3HY7 A;  1HY7 A;  1JH1 A;  1KAP P;  1Q3A A;  1D8F A;  1PWQ A;  1KUH A;  3TS4 A;  1BQO A;  1XAX A;  5JMY A;  3O64 A;  4XBH A;  4I03 A;  3EDI A;  4GWN A;  5D1S A;  2X3B A;  5D1U A;  1ZS0 A;  2AIG P;  5I43 A;  456C A;  2QPJ A;  1SAT A;  1PWW A;  1R54 A;  1IAA A;  2OY2 A;  4ILW D;  3DNG A;  4WF6 A;  2MZH A;  3GBO A;  4L6T A;  1ZXC A;  3RTS A;  2Y6D A;  3TT4 A;  1BSW A;  4HMA A;  3EDG A;  3HDB A;  3MA2 A;  4JIJ A;  2L0R A;  3I7I A;  5BPA A;  1GXD A;  3LIL A;  5I3M A;  1RM8 A;  3LQB A;  3WV1 A;  1EB6 A;  1YP1 A;  4DPE A;  5I12 A;  1ZTQ A;  1HV5 A;  1OZ9 A;  1GKD A;  1IAG A;  1D8M A;  1GE7 A;  4IJO A;  1PWP A;  4WKI A;  2DW0 A;  5D1T A;  4WKE A;  2USN A;  1CK7 A;  3KRY A;  2FV5 A;  1FBL A;  1BM6 A;  4FXY P;  2HU6 A;  1Y8J A;  4ON1 A;  2MLR A;  3DWB A;  1BKC I;  3G42 A;  4H49 A;  3SHI A;  2JT5 A;  4XM7 A;  3WV2 A;  5LAB A;  3Q2H A;  4FU4 A;  2OZR A;  3LJG A;  1B8Y A;  4AXQ A;  1CGE A;  1GKC A;  1CGL A;  1H71 P;  4A3W A;  1MNC A;  1O0Q A;  2KRJ A;  1AF0 A;  1IAD A;  1UTZ A;  2J83 A;  3EDZ A;  3K7N A;  3O2X A;  3EDH A;  1G49 A;  3AIG A;  1JIZ A;  2ERO A;  5I2Z A;  1O0T A;  1OMJ A;  2W14 A;  4DF9 A;  4AIG A;  3F18 A;  2JNP A;  4WZV A;  1CAQ A;  1G9K A;  3LKA A;  2O3E A;  3NX7 A;  1KBC A;  4DD8 A;  1JJ9 A;  4L19 A;  3ZXH A;  1OM8 A;  3EHY A;  2DDY A;  4Q1L A;  1I73 A;  1XFX A;  4H3X A;  1ZP5 A;  1C3I A;  1JAQ A;  2FV9 A;  4EFS A;  1K7G A;  2D1N A;  1BUV M;  3LUM A;  4PKW A;  2V4B A;  1QUA A;  1YCM A;  3DL1 A;  1Y0V A;  4H76 A;  1XFU A;  1UMS A;  1GO7 P;  5BOT A;  3N2V A;  1BQQ M;  1XUD A;  4FVL A;  2E2D A;  1QJI A;  4QKZ A;  2I47 A;  2RJQ A;  3F1A A;  1USN A;  3F16 A;  4PKT A;  3P1V A;  4H84 A;  4ZR5 A;  3V96 B;  2AYK A;  3LMC A;  1QIB A;  1AST A;  4PKU A;  1CIZ A;  5L7F A;  3EHX A;  1UTT A;  3WV3 A;  2DW1 A;  1SU3 A;  2Y6C A;  4JA1 A;  4JQG A;  5BOY A;  1DMT A;  3LIK A;  3DTK A;  4L7A A;  2TCL A;  1BZS A;  1BKC E;  1R1J A;  3TSK A;  2YUF A;  3LUN A;  5H8X A;  2W12 A;  2A8H A;  3LQ0 A;  1R1H A;  4AYK A;  2OW0 A;  1CGF A;  3B8Z A;  4XM8 A;  5B5O A;  3F19 A;  2OW1 A;  1XFZ A;  2CLT A;  3KWV C;  4HX3 A;  3DTE A;  1ZXV A;  2X3A A;  1HTD A;  1QIC A;  2MZI A;  1PWV A;  1AYK A;  4XCT A;  1GE5 A;  2Z2D A;  3I7G A;  4GF1 A;  3TVC A;  3E8R A;  5L79 A;  4H2E A;  4JPA A;  1I1I P;  3DPF A;  3ZUK A;  3U1R A;  1Z3J A;  1ZVX A;  1AKL A;  3VI1 A;  5D7W A;  1JAP A;  1SMP A;  1R1I A;  1A85 A;  3HYG A;  4H30 A;  4WK7 A;  1JKY A;  3HB2 P;  1FM1 A;  3LIR A;  1OS9 A;  4DV8 A;  2RJP A;  1K7I A;  4PKR A;  2PJT A;  2ERQ A;  1CQR A;  1XFW A;  1FLS A;  1HFC A;  3LJZ A;  2OXU A;  1YQY A;  1JIW P;  1RMZ A;  1UMT A;  1G12 A;  3G5C A;  2CKI A;  4PKS A;  1K7Q A;  1BKC A;  3CKI A;  4JP4 A;  3UVC A;  3B92 A;  2W0D A;  5D3C A;  1OO9 A;  2DDF A;  1Y93 A;  3AYK A;  3DPE A;  2K9C A;  2OW9 A;  2W13 A;  1D7X A;  3BA0 A;  4I35 A;  1GE6 A;  1D5J A;  1QIA A;  3F17 A;  1L6J A;  3KEJ A;  2OVZ A;  3RTT A;  3DSL A;  2YIG A;  1XFY A;  3KMC A;  2OXW A;  1I76 A;  2O36 A;  1HOV A;  2N8R A;  3KHI A;  5I0L A;  3USN A;  3KEC A;  1ATL A;  1JAN A;  1DTH A;  3LJT A;  3VTG A;  3HDA P;  3B2Z A;  5D2B A;  2OXZ A;  1KUK A;  4H82 A;  2WOA A;  1XFV A;  4GR3 A;  3AYU A;  2MZE A;  4PKQ A;  2E3X A;  1CXV A;  1PWU A;  4GUY A;  4PKV A;  1R55 A;  1MMP A;  1IAB A;  1MMB A;  1B3D A;  4G0D A;  5CUH A;  2J0T A;  2SRT A;  5I4O A;  1BIW A;  2X3C A;  3EWJ A;  1A86 A;  1OM6 A;  1BUD A;  2XS4 A;  3LE9 A;  1SLN A;  1JAO A;  3ZVS A;  2W15 A;  3KEK A;  830C A;  1EAK A;  2WO9 A;  1UEA A;  4IN9 A;  4AUO A;  3HBU P;  4R3V A;  5B5P A;  1J7N A;  2DW2 A;  1KUG A;  1OS2 A;  1C7K A;  3LGP A;  4G9L A;  1OM7 A;  4GR8 A;  1G05 A;  3K7L A;  2JSD A;  2YB9 A;  1S4B P;  5CZM A;  2OVX A;  4L63 A;  2JT6 A;  2X7M A;  4FXQ A;  1HFS A;  1XM5 A;  2MLS A;  2WO8 A;  1WNI A; 
#chains in the Genus database with same CATH homology
 1ROS A;  1IAE A;  1SRP A;  4GWM A;  3HBV P;  2OW2 A;  4A7B A;  1MMR A;  3DTI A;  1YOU A;  3HY9 A;  3LEA A;  1KUI A;  3OHL A;  2POJ A;  1EUB A;  1C8T A;  4GR0 A;  1XUR A;  4XM6 A;  4GQL A;  3KME A;  4IUW A;  3ELM A;  2OI0 A;  3LK8 A;  966C A;  3Q2G A;  2XS3 A;  3P24 A;  1IAC A;  1GO8 P;  1XUC A;  3N2U A;  1G4K A;  3L0T A;  1JK3 A;  2K2G A;  1ND1 A;  3F15 A;  4H1Q A;  4J4M A;  1SLM A;  3OHO A;  2JIH A;  3L0V A;  2ERP A;  2D1O A;  4CTH A;  1KUF A;  1QJJ A;  2OY4 A;  1MMQ A;  5CXA A;  3HY7 A;  1HY7 A;  1JH1 A;  1KAP P;  1Q3A A;  1D8F A;  1PWQ A;  1KUH A;  3TS4 A;  1BQO A;  5JMY A;  3O64 A;  4XBH A;  4I03 A;  3EDI A;  4GWN A;  5D1S A;  2X3B A;  5D1U A;  1ZS0 A;  2AIG P;  5I43 A;  456C A;  2QPJ A;  1SAT A;  1PWW A;  1R54 A;  1IAA A;  2OY2 A;  4ILW D;  3DNG A;  4WF6 A;  2MZH A;  3GBO A;  4L6T A;  1ZXC A;  3RTS A;  2Y6D A;  3TT4 A;  1BSW A;  4HMA A;  3EDG A;  3HDB A;  3MA2 A;  4JIJ A;  2L0R A;  3I7I A;  5BPA A;  1GXD A;  3LIL A;  5I3M A;  1RM8 A;  3LQB A;  3WV1 A;  1EB6 A;  1YP1 A;  4DPE A;  5I12 A;  1ZTQ A;  1HV5 A;  1GKD A;  1IAG A;  1D8M A;  1GE7 A;  4IJO A;  1PWP A;  4WKI A;  2DW0 A;  5D1T A;  4WKE A;  2USN A;  1CK7 A;  3KRY A;  2FV5 A;  1FBL A;  1BM6 A;  4FXY P;  2HU6 A;  1Y8J A;  4ON1 A;  2MLR A;  3DWB A;  1BKC I;  3G42 A;  4H49 A;  3SHI A;  2JT5 A;  4XM7 A;  3WV2 A;  5LAB A;  3Q2H A;  4FU4 A;  2OZR A;  3LJG A;  1B8Y A;  4AXQ A;  1CGE A;  1GKC A;  1CGL A;  1H71 P;  4A3W A;  1MNC A;  1O0Q A;  2KRJ A;  1AF0 A;  1IAD A;  1UTZ A;  2J83 A;  3EDZ A;  3K7N A;  3O2X A;  3EDH A;  1G49 A;  3AIG A;  1JIZ A;  2ERO A;  5I2Z A;  1O0T A;  1OMJ A;  2W14 A;  4DF9 A;  4AIG A;  3F18 A;  2JNP A;  4WZV A;  1CAQ A;  1G9K A;  3LKA A;  2O3E A;  3NX7 A;  1KBC A;  4DD8 A;  1JJ9 A;  4L19 A;  3ZXH A;  1OM8 A;  3EHY A;  2DDY A;  4Q1L A;  1I73 A;  1XFX A;  4H3X A;  1ZP5 A;  1C3I A;  1JAQ A;  2FV9 A;  4EFS A;  1K7G A;  2D1N A;  1BUV M;  3LUM A;  4PKW A;  2V4B A;  1QUA A;  1YCM A;  3DL1 A;  1Y0V A;  4H76 A;  1XFU A;  1UMS A;  1GO7 P;  5BOT A;  3N2V A;  1BQQ M;  1XUD A;  4FVL A;  2E2D A;  1QJI A;  4QKZ A;  2I47 A;  2RJQ A;  3F1A A;  1USN A;  3F16 A;  4PKT A;  3P1V A;  4H84 A;  4ZR5 A;  3V96 B;  2AYK A;  3LMC A;  1QIB A;  1AST A;  4PKU A;  1CIZ A;  5L7F A;  3EHX A;  1UTT A;  3WV3 A;  2DW1 A;  1SU3 A;  2Y6C A;  4JA1 A;  4JQG A;  5BOY A;  1DMT A;  3LIK A;  3DTK A;  4L7A A;  2TCL A;  1BZS A;  1BKC E;  1R1J A;  3TSK A;  2YUF A;  3LUN A;  5H8X A;  2W12 A;  2A8H A;  3LQ0 A;  1R1H A;  4AYK A;  2OW0 A;  1CGF A;  3B8Z A;  4XM8 A;  5B5O A;  3F19 A;  2OW1 A;  1XFZ A;  2CLT A;  3KWV C;  4HX3 A;  3DTE A;  1ZXV A;  2X3A A;  1HTD A;  1QIC A;  2MZI A;  1PWV A;  1AYK A;  4XCT A;  1GE5 A;  2Z2D A;  3I7G A;  4GF1 A;  3TVC A;  3E8R A;  5L79 A;  4H2E A;  4JPA A;  1I1I P;  3DPF A;  3ZUK A;  3U1R A;  1Z3J A;  1ZVX A;  1AKL A;  3VI1 A;  5D7W A;  1JAP A;  1SMP A;  1R1I A;  1A85 A;  3HYG A;  4H30 A;  4WK7 A;  1JKY A;  3HB2 P;  1FM1 A;  3LIR A;  1OS9 A;  4DV8 A;  2RJP A;  1K7I A;  4PKR A;  2PJT A;  2ERQ A;  1CQR A;  1XFW A;  3LJZ A;  1FLS A;  1HFC A;  2OXU A;  1YQY A;  1JIW P;  1RMZ A;  1UMT A;  1G12 A;  3G5C A;  2CKI A;  4PKS A;  1K7Q A;  1BKC A;  3CKI A;  4JP4 A;  3UVC A;  3B92 A;  2W0D A;  5D3C A;  1OO9 A;  2DDF A;  1Y93 A;  3AYK A;  3DPE A;  2K9C A;  2OW9 A;  2W13 A;  1D7X A;  3BA0 A;  4I35 A;  1GE6 A;  1D5J A;  1QIA A;  3F17 A;  1L6J A;  3KEJ A;  2OVZ A;  3RTT A;  3DSL A;  2YIG A;  1XFY A;  3KMC A;  2OXW A;  1I76 A;  2O36 A;  1HOV A;  2N8R A;  3KHI A;  5I0L A;  3USN A;  3KEC A;  1ATL A;  1JAN A;  1DTH A;  3LJT A;  3VTG A;  3HDA P;  3B2Z A;  5D2B A;  2OXZ A;  1KUK A;  4H82 A;  2WOA A;  1XFV A;  4GR3 A;  3AYU A;  2MZE A;  4PKQ A;  2E3X A;  1CXV A;  1PWU A;  4GUY A;  4PKV A;  1R55 A;  1MMP A;  1IAB A;  1MMB A;  1B3D A;  4G0D A;  5CUH A;  2J0T A;  2SRT A;  5I4O A;  1BIW A;  2X3C A;  3EWJ A;  1A86 A;  1OM6 A;  1BUD A;  2XS4 A;  3LE9 A;  1SLN A;  1JAO A;  3ZVS A;  2W15 A;  3KEK A;  830C A;  1EAK A;  2WO9 A;  1UEA A;  4IN9 A;  4AUO A;  3HBU P;  4R3V A;  5B5P A;  1J7N A;  2DW2 A;  1KUG A;  1OS2 A;  1C7K A;  3LGP A;  4G9L A;  1OM7 A;  4GR8 A;  1G05 A;  3K7L A;  2JSD A;  2YB9 A;  1S4B P;  5CZM A;  2OVX A;  4L63 A;  2JT6 A;  2X7M A;  4FXQ A;  1HFS A;  2MLS A;  2WO8 A;  1WNI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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