3L0TA

Crystal structure of catalytic domain of tace with hydantoin inhibitor
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
257
structure length
254
Chain Sequence
PDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGSPSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Disintegrin and metalloproteinase domain-containing protein
publication title Discovery and SAR of hydantoin TACE inhibitors.
pubmed doi rcsb
source organism Homo sapiens
total genus 81
structure length 254
sequence length 257
chains with identical sequence B
ec nomenclature ec 3.4.24.86: ADAM 17 endopeptidase.
pdb deposition date 2009-12-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13688 Reprolysin_5 Metallo-peptidase family M12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3l0tA00
1YOUA 2ERPA 2Y6DA 3KEKA 3P24A 4H1QA 1XFYA 2DW1A 4WKEA 1WNIA 3F17A 4CTHA 4DV8A 4FXYP 2A8HA 3EDHA 1SRPA 1XFXA 1JK3A 1UEAA 1GE5A 1XUCA 3E8RA 3F19A 4GR0A 5BOTA 4JP4A 2MLRA 2WO9A 2D1NA 2MZIA 3TVCA 2E3XA 1HY7A 3HBUP 5I43A 3HY7A 3LGPA 1MMPA 1ZVXA 3GBOA 1CXVA 2PJTA 1KBCA 2POJA 2AIGP 3N2VA 4G0DA 3G5CA 5I3MA 3P1VA 1IAAA 3LILA 2WO8A 2X3CA 4DD8A 3O64A 1CK7A 2W15A 1EB6A 1R55A 3KHIA 4DPEA 4JQGA 4G9LA 1OO9A 2O36A 1IABA 1AYKA 2TCLA 1R1IA 5H8XA 1C7KA 1I73A 830CA 1BSWA 1QIAA 1GO8P 3KECA 5BOYA 4A7BA 4WK7A 3F1AA 3VTGA 3DL1A 4AUOA 2DW0A 1DMTA 1J7NA 2JSDA 4H84A 2WOAA 5L79A 2AYKA 1CIZA 1I76A 2HU6A 2JNPA 3KMCA 3HB2P 3KEJA 2QPJA 4L19A 1BUVM 1L6JA 2CLTA 5BPAA 3HDBA 3F16A 5CXAA 4GR8A 2ERQA 2Y6CA 1GXDA 3WV1A 3K7LA 4XM6A 3LQ0A 2J83A 4FXQA 1BM6A 4FVLA 1G05A 3V96B 1OM6A 4J4MA 1R54A 2RJPA 3USNA 4ON1A 4XM7A 3OHOA 5CZMA 1S4BP 3B92A 5I2ZA 1AF0A 4XBHA 4Q1LA 1ZTQA 4JPAA 1R1JA 1OM8A 4WKIA 1BQOA 1K7IA 1KUGA 2EROA 1XUDA 1D5JA 3RTSA 5I0LA 2OVXA 3LIKA 4IN9A 5L7FA 4IJOA 1JIZA 4PKUA 4R3VA 1IAEA 3EDZA 3U1RA 4H30A 2X7MA 1YP1A 3DNGA 1JAQA 1CAQA 3B8ZA 3G42A 2X3AA 1JJ9A 1MNCA 3AIGA 3F15A 3I7GA 2CKIA 1JAOA 1EAKA 2OW0A 4PKWA 4AYKA 1PWUA 1H71P 1QIBA 2FV5A 1C8TA 1CGLA 2W13A 5JMYA 3UVCA 4PKSA 3L0VA 1JAPA 5CUHA 2D1OA 1BKCI 3Q2HA 2MLSA 1D8FA 1SMPA 3ZUKA 1O0QA 1CGEA 1BKCE 3F18A 1MMQA 456CA 2DDYA 1HFCA 5I12A 3CKIA 4I35A 3EHYA 4IUWA 1Q3AA 3DSLA 5D7WA 1EUBA 4JA1A 1GKCA 1KAPP 1PWPA 1PWWA 1ZXCA 1ZXVA 4PKTA 2X3BA 1JIWP 1XFWA 1UTTA 5D1TA 3TS4A 1G4KA 2OW2A 1QUAA 1IACA 4H82A 1UMTA 1RMZA 3LJZA 1Y93A 3N2UA 5D1SA 3AYKA 3L0TA 5D3CA 1UMSA 2OVZA 1KUKA 5I4OA 4PKVA 1ND1A 3LE9A 4AIGA 3LKAA 1HFSA 3LUNA 1CQRA 1OM7A 4HX3A 3Q2GA 2OW1A 1D7XA 1K7QA 1SLNA 2XS3A 2O3EA 1KUIA 4A3WA 2MZEA 1IAGA 1A86A 2OW9A 2USNA 4WF6A 1ZS0A 1QJJA 1GE7A 4ILWD 3KWVC 3HYGA 3O2XA 1ROSA 1C3IA 4QKZA 3EHXA 3LIRA 1JKYA 4GWMA 2K2GA 1BUDA 1XFVA 3MA2A 1HOVA 1GE6A 2OY4A 1KUHA 3HBVP 3LMCA 1KUFA 1ZP5A 1R1HA 1Z3JA 1G49A 1YQYA 1B8YA 4GR3A 1FM1A 4H2EA 2MZHA 1FBLA 2YIGA 3K7NA 5D2BA 3WV2A 4EFSA 2W14A 3AYUA 3LJTA 1A85A 4I03A 3LJGA 2V4BA 2OXUA 1HTDA 2N8RA 1BQQM 1YCMA 1QICA 1PWQA 4PKRA 2W0DA 2E2DA 1ASTA 1BIWA 4GUYA 2OXZA 4GF1A 3EDIA 4ZR5A 1B3DA 2L0RA 3OHLA 2OY2A 1AKLA 2OI0A 2XS4A 2OZRA 3VI1A 1OS2A 3I7IA 5D1UA 1JH1A 3TSKA 1HV5A 3KMEA 3KRYA 4H3XA 2J0TA 3LEAA 1SLMA 1CGFA 1JANA 4GWNA 4HMAA 4DF9A 3EDGA 1OMJA 3HY9A 4PKQA 1GKDA 3TT4A 3LQBA 3B2ZA 1UTZA 1Y8JA 1XFZA 2Z2DA 4H76A 3LUMA 3WV3A 1OS9A 2FV9A 3RTTA 5LABA 1D8MA 1IADA 1SU3A 1DTHA 2DW2A 1G9KA 3LK8A 4JIJA 2OXWA 2DDFA 4WZVA 3EWJA 2RJQA 3NX7A 1BZSA 1PWVA 2JIHA 2YB9A 1I1IP 3DPEA 3ZVSA 1K7GA 3SHIA 3DPFA 4XM8A 3DWBA 1GO7P 1O0TA 2JT6A 1USNA 5B5OA 1G12A 3ZXHA 1BKCA 1SATA 1MMBA 1MMRA 4L63A 2SRTA 966CA 1XURA 2JT5A 4H49A 1QJIA 5B5PA 1XFUA 2W12A 3HDAP 4AXQA 4XCTA 3ELMA 1FLSA 1ATLA 1Y0VA 2I47A 4FU4A 2K9CA 4GQLA 3BA0A 1RM8A 2KRJA 4L6TA
chains in the Genus database with same CATH superfamily
1YOUA 2ERPA 2Y6DA 3KEKA 3P24A 4H1QA 1XFYA 2DW1A 4WKEA 1WNIA 3F17A 4CTHA 4DV8A 4FXYP 2A8HA 3EDHA 1SRPA 1XFXA 1JK3A 1UEAA 1GE5A 1XUCA 3E8RA 3F19A 4GR0A 5BOTA 4JP4A 2MLRA 2WO9A 2D1NA 2MZIA 3TVCA 2E3XA 1HY7A 3HBUP 5I43A 3HY7A 3LGPA 1MMPA 1ZVXA 3GBOA 1CXVA 2PJTA 1KBCA 2POJA 2AIGP 3N2VA 4G0DA 3G5CA 5I3MA 3P1VA 1IAAA 3LILA 2WO8A 2X3CA 4DD8A 3O64A 1CK7A 2W15A 1EB6A 1R55A 3KHIA 4DPEA 4JQGA 4G9LA 1OO9A 2O36A 1IABA 1AYKA 2TCLA 1R1IA 5H8XA 1C7KA 1I73A 830CA 1BSWA 1QIAA 1GO8P 1OZ9A 3KECA 5BOYA 4A7BA 3DTKA 4L7AA 4WK7A 3F1AA 3VTGA 3DL1A 4AUOA 2DW0A 1DMTA 1J7NA 2JSDA 4H84A 2WOAA 5L79A 2AYKA 1CIZA 1I76A 2HU6A 2JNPA 3KMCA 3KEJA 3HB2P 2QPJA 4L19A 1BUVM 1L6JA 2CLTA 5BPAA 3HDBA 3F16A 5CXAA 4GR8A 2ERQA 2Y6CA 1GXDA 3WV1A 3K7LA 4XM6A 3LQ0A 2J83A 4FXQA 1BM6A 4FVLA 1G05A 3V96B 1OM6A 4J4MA 1R54A 2RJPA 3USNA 4ON1A 4XM7A 3OHOA 5CZMA 1S4BP 3B92A 5I2ZA 1AF0A 4XBHA 4Q1LA 1ZTQA 4JPAA 1R1JA 1OM8A 4WKIA 1BQOA 1K7IA 1KUGA 2EROA 1XUDA 1D5JA 3RTSA 5I0LA 2OVXA 3LIKA 4IN9A 5L7FA 4IJOA 1JIZA 4PKUA 4R3VA 1IAEA 3EDZA 3U1RA 4H30A 2X7MA 1YP1A 3DNGA 1JAQA 1CAQA 3B8ZA 3G42A 2X3AA 1JJ9A 1MNCA 3AIGA 3F15A 3I7GA 2CKIA 1JAOA 1EAKA 2OW0A 4PKWA 4AYKA 1PWUA 1H71P 1QIBA 2FV5A 1C8TA 1CGLA 2W13A 5JMYA 3UVCA 4PKSA 3L0VA 1JAPA 5CUHA 2D1OA 1BKCI 3Q2HA 2MLSA 1D8FA 1SMPA 3ZUKA 1XM5A 1O0QA 1CGEA 1BKCE 3F18A 1MMQA 456CA 2DDYA 3DTIA 1HFCA 5I12A 3CKIA 4I35A 3EHYA 4IUWA 1Q3AA 3DSLA 5D7WA 1EUBA 4JA1A 1GKCA 1KAPP 1PWPA 1PWWA 1ZXCA 1ZXVA 4PKTA 2X3BA 1JIWP 1XFWA 1UTTA 5D1TA 3TS4A 1G4KA 2OW2A 1QUAA 1IACA 4H82A 1UMTA 1RMZA 3LJZA 1Y93A 3N2UA 5D1SA 3AYKA 3L0TA 5D3CA 1UMSA 2OVZA 1KUKA 5I4OA 4PKVA 1ND1A 3LE9A 4AIGA 3LKAA 1HFSA 3LUNA 1CQRA 1OM7A 4HX3A 3Q2GA 2OW1A 1D7XA 1K7QA 1SLNA 2XS3A 2O3EA 1KUIA 4A3WA 2MZEA 1IAGA 2YUFA 1A86A 2OW9A 2USNA 4WF6A 1ZS0A 1QJJA 1GE7A 4ILWD 3KWVC 3HYGA 3O2XA 1ROSA 1C3IA 4QKZA 3EHXA 3LIRA 1JKYA 4GWMA 2K2GA 1BUDA 1XFVA 3MA2A 1HOVA 1GE6A 2OY4A 1KUHA 3HBVP 3LMCA 1KUFA 1ZP5A 1R1HA 1Z3JA 1G49A 1YQYA 1B8YA 4GR3A 1FM1A 4H2EA 2MZHA 1FBLA 2YIGA 3K7NA 5D2BA 3WV2A 4EFSA 2W14A 3AYUA 3DTEA 3LJTA 1A85A 4I03A 3LJGA 2V4BA 2OXUA 1HTDA 2N8RA 1BQQM 1YCMA 1QICA 1PWQA 4PKRA 2W0DA 2E2DA 1ASTA 1BIWA 4GUYA 2OXZA 4GF1A 3EDIA 4ZR5A 1B3DA 2L0RA 3OHLA 2OY2A 1AKLA 2OI0A 2XS4A 2OZRA 3VI1A 1OS2A 3I7IA 5D1UA 1JH1A 3TSKA 1HV5A 3KMEA 3KRYA 4H3XA 2J0TA 3LEAA 1SLMA 1CGFA 1JANA 4GWNA 4HMAA 4DF9A 3EDGA 1OMJA 3HY9A 4PKQA 1GKDA 3TT4A 3LQBA 3B2ZA 1UTZA 1Y8JA 1XFZA 2Z2DA 4H76A 3LUMA 3WV3A 1OS9A 2FV9A 3RTTA 5LABA 1D8MA 1IADA 1SU3A 1DTHA 2DW2A 1G9KA 3LK8A 4JIJA 2OXWA 2DDFA 4WZVA 3EWJA 2RJQA 3NX7A 1BZSA 1PWVA 2JIHA 2YB9A 1I1IP 3DPEA 3ZVSA 1K7GA 3SHIA 1TVIA 3DPFA 1XAXA 4XM8A 3DWBA 1GO7P 1O0TA 2JT6A 1USNA 5B5OA 1G12A 3ZXHA 1BKCA 1SATA 1MMBA 1MMRA 4L63A 2SRTA 966CA 1XURA 2JT5A 4H49A 1QJIA 5B5PA 1XFUA 2W12A 3HDAP 4AXQA 4XCTA 3ELMA 1FLSA 1ATLA 1Y0VA 2I47A 4FU4A 2K9CA 4GQLA 3BA0A 1RM8A 2KRJA 4L6TA
chains in the Genus database with same CATH topology
1YOUA 2ERPA 2Y6DA 3KEKA 3P24A 4H1QA 1XFYA 2DW1A 4WKEA 1WNIA 3F17A 4CTHA 4DV8A 4FXYP 2A8HA 3EDHA 1SRPA 1XFXA 1JK3A 1UEAA 1GE5A 1XUCA 3E8RA 3F19A 4GR0A 5BOTA 4JP4A 2MLRA 2WO9A 2D1NA 2MZIA 3TVCA 2E3XA 1HY7A 3HBUP 5I43A 3HY7A 3LGPA 1MMPA 1ZVXA 3GBOA 1CXVA 2PJTA 1KBCA 2POJA 2AIGP 3N2VA 4G0DA 3G5CA 5I3MA 3P1VA 1IAAA 3LILA 2WO8A 2X3CA 4DD8A 3O64A 1CK7A 2W15A 1EB6A 1R55A 3KHIA 4DPEA 4JQGA 4G9LA 1OO9A 2O36A 1IABA 1AYKA 2TCLA 1R1IA 5H8XA 1C7KA 1I73A 830CA 1BSWA 1QIAA 1GO8P 3KECA 5BOYA 4A7BA 3DTKA 4L7AA 4WK7A 3F1AA 3VTGA 3DL1A 4AUOA 2DW0A 1DMTA 1J7NA 2JSDA 4H84A 2WOAA 5L79A 2AYKA 1CIZA 1I76A 2HU6A 2JNPA 3KMCA 3KEJA 3HB2P 2QPJA 4L19A 1BUVM 1L6JA 2CLTA 5BPAA 3HDBA 3F16A 5CXAA 4GR8A 2ERQA 2Y6CA 1GXDA 3WV1A 3K7LA 4XM6A 3LQ0A 2J83A 4FXQA 1BM6A 4FVLA 1G05A 3V96B 1OM6A 4J4MA 1R54A 2RJPA 3USNA 4ON1A 4XM7A 3OHOA 5CZMA 1S4BP 3B92A 5I2ZA 1AF0A 4XBHA 4Q1LA 1ZTQA 4JPAA 1R1JA 1OM8A 4WKIA 1BQOA 1K7IA 1KUGA 2EROA 1XUDA 1D5JA 3RTSA 5I0LA 2OVXA 3LIKA 4IN9A 5L7FA 4IJOA 1JIZA 4PKUA 4R3VA 1IAEA 3EDZA 3U1RA 4H30A 2X7MA 1YP1A 3DNGA 1JAQA 1CAQA 3B8ZA 3G42A 2X3AA 1JJ9A 1MNCA 3AIGA 3F15A 3I7GA 2CKIA 1JAOA 1EAKA 2OW0A 4PKWA 4AYKA 1PWUA 1H71P 1QIBA 2FV5A 1C8TA 1CGLA 2W13A 5JMYA 3UVCA 4PKSA 3L0VA 1JAPA 5CUHA 2D1OA 1BKCI 3Q2HA 2MLSA 1D8FA 1SMPA 3ZUKA 1O0QA 1CGEA 1BKCE 3F18A 1MMQA 456CA 2DDYA 3DTIA 1HFCA 5I12A 3CKIA 4I35A 3EHYA 4IUWA 1Q3AA 3DSLA 5D7WA 1EUBA 4JA1A 1GKCA 1KAPP 1PWPA 1PWWA 1ZXCA 1ZXVA 4PKTA 2X3BA 1JIWP 1XFWA 1UTTA 5D1TA 3TS4A 1G4KA 2OW2A 1QUAA 1IACA 4H82A 1UMTA 1RMZA 3LJZA 1Y93A 3N2UA 5D1SA 3AYKA 3L0TA 5D3CA 1UMSA 2OVZA 1KUKA 5I4OA 4PKVA 1ND1A 3LE9A 4AIGA 3LKAA 1HFSA 3LUNA 1CQRA 1OM7A 4HX3A 3Q2GA 2OW1A 1D7XA 1K7QA 1SLNA 2XS3A 2O3EA 1KUIA 4A3WA 2MZEA 1IAGA 2YUFA 1A86A 2OW9A 2USNA 4WF6A 1ZS0A 1QJJA 1GE7A 4ILWD 3KWVC 3HYGA 3O2XA 1ROSA 1C3IA 4QKZA 3EHXA 3LIRA 1JKYA 4GWMA 2K2GA 1BUDA 1XFVA 3MA2A 1HOVA 1GE6A 2OY4A 1KUHA 3HBVP 3LMCA 1KUFA 1ZP5A 1R1HA 1Z3JA 1G49A 1YQYA 1B8YA 4GR3A 1FM1A 4H2EA 2MZHA 1FBLA 2YIGA 3K7NA 5D2BA 3WV2A 4EFSA 2W14A 3AYUA 3DTEA 3LJTA 1A85A 4I03A 3LJGA 2V4BA 2OXUA 1HTDA 2N8RA 1BQQM 1YCMA 1QICA 1PWQA 4PKRA 2W0DA 2E2DA 1ASTA 1BIWA 4GUYA 2OXZA 4GF1A 3EDIA 4ZR5A 1B3DA 2L0RA 3OHLA 2OY2A 1AKLA 2OI0A 2XS4A 2OZRA 3VI1A 1OS2A 3I7IA 5D1UA 1JH1A 3TSKA 1HV5A 3KMEA 3KRYA 4H3XA 2J0TA 3LEAA 1SLMA 1CGFA 1JANA 4GWNA 4HMAA 4DF9A 3EDGA 1OMJA 3HY9A 4PKQA 1GKDA 3TT4A 3LQBA 3B2ZA 1UTZA 1Y8JA 1XFZA 2Z2DA 4H76A 3LUMA 3WV3A 1OS9A 2FV9A 3RTTA 5LABA 1D8MA 1IADA 1SU3A 1DTHA 2DW2A 1G9KA 3LK8A 4JIJA 2OXWA 2DDFA 4WZVA 3EWJA 2RJQA 3NX7A 1BZSA 1PWVA 2JIHA 2YB9A 1I1IP 3DPEA 3ZVSA 1K7GA 3SHIA 3DPFA 4XM8A 3DWBA 1GO7P 1O0TA 2JT6A 1USNA 5B5OA 1G12A 3ZXHA 1BKCA 1SATA 1MMBA 1MMRA 4L63A 2SRTA 966CA 1XURA 2JT5A 4H49A 1QJIA 5B5PA 1XFUA 2W12A 3HDAP 4AXQA 4XCTA 3ELMA 1FLSA 1ATLA 1Y0VA 2I47A 4FU4A 2K9CA 4GQLA 3BA0A 1RM8A 2KRJA 4L6TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YOU A;  2ERP A;  2Y6D A;  3KEK A;  3P24 A;  4H1Q A;  1XFY A;  2DW1 A;  4WKE A;  1WNI A;  3F17 A;  4CTH A;  4DV8 A;  4FXY P;  2A8H A;  3EDH A;  1SRP A;  1XFX A;  1JK3 A;  1UEA A;  1GE5 A;  1XUC A;  3E8R A;  3F19 A;  4GR0 A;  5BOT A;  4JP4 A;  2MLR A;  2WO9 A;  2D1N A;  2MZI A;  3TVC A;  2E3X A;  1HY7 A;  3HBU P;  5I43 A;  3HY7 A;  3LGP A;  1MMP A;  1ZVX A;  3GBO A;  1CXV A;  2PJT A;  1KBC A;  2POJ A;  2AIG P;  3N2V A;  4G0D A;  3G5C A;  5I3M A;  3P1V A;  1IAA A;  3LIL A;  2WO8 A;  2X3C A;  4DD8 A;  3O64 A;  1CK7 A;  2W15 A;  1EB6 A;  1R55 A;  3KHI A;  4DPE A;  4JQG A;  4G9L A;  1OO9 A;  2O36 A;  1IAB A;  1AYK A;  2TCL A;  1R1I A;  5H8X A;  1C7K A;  1I73 A;  830C A;  1BSW A;  1QIA A;  1GO8 P;  3KEC A;  5BOY A;  4A7B A;  4WK7 A;  3F1A A;  3VTG A;  3DL1 A;  4AUO A;  2DW0 A;  1DMT A;  1J7N A;  2JSD A;  4H84 A;  2WOA A;  5L79 A;  2AYK A;  1CIZ A;  1I76 A;  2HU6 A;  2JNP A;  3KMC A;  3HB2 P;  3KEJ A;  2QPJ A;  4L19 A;  1BUV M;  1L6J A;  2CLT A;  5BPA A;  3HDB A;  3F16 A;  5CXA A;  4GR8 A;  2ERQ A;  2Y6C A;  1GXD A;  3WV1 A;  3K7L A;  4XM6 A;  3LQ0 A;  2J83 A;  4FXQ A;  1BM6 A;  4FVL A;  1G05 A;  3V96 B;  1OM6 A;  4J4M A;  1R54 A;  2RJP A;  3USN A;  4ON1 A;  4XM7 A;  3OHO A;  5CZM A;  1S4B P;  3B92 A;  5I2Z A;  1AF0 A;  4XBH A;  4Q1L A;  1ZTQ A;  4JPA A;  1R1J A;  1OM8 A;  4WKI A;  1BQO A;  1K7I A;  1KUG A;  2ERO A;  1XUD A;  1D5J A;  3RTS A;  5I0L A;  2OVX A;  3LIK A;  4IN9 A;  5L7F A;  4IJO A;  1JIZ A;  4PKU A;  4R3V A;  1IAE A;  3EDZ A;  3U1R A;  4H30 A;  2X7M A;  1YP1 A;  3DNG A;  1JAQ A;  1CAQ A;  3B8Z A;  3G42 A;  2X3A A;  1JJ9 A;  1MNC A;  3AIG A;  3F15 A;  3I7G A;  2CKI A;  1JAO A;  1EAK A;  2OW0 A;  4PKW A;  4AYK A;  1PWU A;  1H71 P;  1QIB A;  2FV5 A;  1C8T A;  1CGL A;  2W13 A;  5JMY A;  3UVC A;  4PKS A;  3L0V A;  1JAP A;  5CUH A;  2D1O A;  1BKC I;  3Q2H A;  2MLS A;  1D8F A;  1SMP A;  3ZUK A;  1O0Q A;  1CGE A;  1BKC E;  3F18 A;  1MMQ A;  456C A;  2DDY A;  1HFC A;  5I12 A;  3CKI A;  4I35 A;  3EHY A;  4IUW A;  1Q3A A;  3DSL A;  5D7W A;  1EUB A;  4JA1 A;  1GKC A;  1KAP P;  1PWP A;  1PWW A;  1ZXC A;  1ZXV A;  4PKT A;  2X3B A;  1JIW P;  1XFW A;  1UTT A;  5D1T A;  3TS4 A;  1G4K A;  2OW2 A;  1QUA A;  1IAC A;  4H82 A;  1UMT A;  1RMZ A;  3LJZ A;  1Y93 A;  3N2U A;  5D1S A;  3AYK A;  3L0T A;  5D3C A;  1UMS A;  2OVZ A;  1KUK A;  5I4O A;  4PKV A;  1ND1 A;  3LE9 A;  4AIG A;  3LKA A;  1HFS A;  3LUN A;  1CQR A;  1OM7 A;  4HX3 A;  3Q2G A;  2OW1 A;  1D7X A;  1K7Q A;  1SLN A;  2XS3 A;  2O3E A;  1KUI A;  4A3W A;  2MZE A;  1IAG A;  1A86 A;  2OW9 A;  2USN A;  4WF6 A;  1ZS0 A;  1QJJ A;  1GE7 A;  4ILW D;  3KWV C;  3HYG A;  3O2X A;  1ROS A;  1C3I A;  4QKZ A;  3EHX A;  3LIR A;  1JKY A;  4GWM A;  2K2G A;  1BUD A;  1XFV A;  3MA2 A;  1HOV A;  1GE6 A;  2OY4 A;  1KUH A;  3HBV P;  3LMC A;  1KUF A;  1ZP5 A;  1R1H A;  1Z3J A;  1G49 A;  1YQY A;  1B8Y A;  4GR3 A;  1FM1 A;  4H2E A;  2MZH A;  1FBL A;  2YIG A;  3K7N A;  5D2B A;  3WV2 A;  4EFS A;  2W14 A;  3AYU A;  3LJT A;  1A85 A;  4I03 A;  3LJG A;  2V4B A;  2OXU A;  1HTD A;  2N8R A;  1BQQ M;  1YCM A;  1QIC A;  1PWQ A;  4PKR A;  2W0D A;  2E2D A;  1AST A;  1BIW A;  4GUY A;  2OXZ A;  4GF1 A;  3EDI A;  4ZR5 A;  1B3D A;  2L0R A;  3OHL A;  2OY2 A;  1AKL A;  2OI0 A;  2XS4 A;  2OZR A;  3VI1 A;  1OS2 A;  3I7I A;  5D1U A;  1JH1 A;  3TSK A;  1HV5 A;  3KME A;  3KRY A;  4H3X A;  2J0T A;  3LEA A;  1SLM A;  1CGF A;  1JAN A;  4GWN A;  4HMA A;  4DF9 A;  3EDG A;  1OMJ A;  3HY9 A;  4PKQ A;  1GKD A;  3TT4 A;  3LQB A;  3B2Z A;  1UTZ A;  1Y8J A;  1XFZ A;  2Z2D A;  4H76 A;  3LUM A;  3WV3 A;  1OS9 A;  2FV9 A;  3RTT A;  5LAB A;  1D8M A;  1IAD A;  1SU3 A;  1DTH A;  2DW2 A;  1G9K A;  3LK8 A;  4JIJ A;  2OXW A;  2DDF A;  4WZV A;  3EWJ A;  2RJQ A;  3NX7 A;  1BZS A;  1PWV A;  2JIH A;  2YB9 A;  1I1I P;  3DPE A;  3ZVS A;  1K7G A;  3SHI A;  3DPF A;  4XM8 A;  3DWB A;  1GO7 P;  1O0T A;  2JT6 A;  1USN A;  5B5O A;  1G12 A;  3ZXH A;  1BKC A;  1SAT A;  1MMB A;  1MMR A;  4L63 A;  2SRT A;  966C A;  1XUR A;  2JT5 A;  4H49 A;  1QJI A;  5B5P A;  1XFU A;  2W12 A;  3HDA P;  4AXQ A;  4XCT A;  3ELM A;  1FLS A;  1ATL A;  1Y0V A;  2I47 A;  4FU4 A;  2K9C A;  4GQL A;  3BA0 A;  1RM8 A;  2KRJ A;  4L6T A; 
#chains in the Genus database with same CATH topology
 1YOU A;  2ERP A;  2Y6D A;  3KEK A;  3P24 A;  4H1Q A;  1XFY A;  2DW1 A;  4WKE A;  1WNI A;  3F17 A;  4CTH A;  4DV8 A;  4FXY P;  2A8H A;  3EDH A;  1SRP A;  1XFX A;  1JK3 A;  1UEA A;  1GE5 A;  1XUC A;  3E8R A;  3F19 A;  4GR0 A;  5BOT A;  4JP4 A;  2MLR A;  2WO9 A;  2D1N A;  2MZI A;  3TVC A;  2E3X A;  1HY7 A;  3HBU P;  5I43 A;  3HY7 A;  3LGP A;  1MMP A;  1ZVX A;  3GBO A;  1CXV A;  2PJT A;  1KBC A;  2POJ A;  2AIG P;  3N2V A;  4G0D A;  3G5C A;  5I3M A;  3P1V A;  1IAA A;  3LIL A;  2WO8 A;  2X3C A;  4DD8 A;  3O64 A;  1CK7 A;  2W15 A;  1EB6 A;  1R55 A;  3KHI A;  4DPE A;  4JQG A;  4G9L A;  1OO9 A;  2O36 A;  1IAB A;  1AYK A;  2TCL A;  1R1I A;  5H8X A;  1C7K A;  1I73 A;  830C A;  1BSW A;  1QIA A;  1GO8 P;  1OZ9 A;  3KEC A;  5BOY A;  4A7B A;  3DTK A;  4L7A A;  4WK7 A;  3F1A A;  3VTG A;  3DL1 A;  4AUO A;  2DW0 A;  1DMT A;  1J7N A;  2JSD A;  4H84 A;  2WOA A;  5L79 A;  2AYK A;  1CIZ A;  1I76 A;  2HU6 A;  2JNP A;  3KMC A;  3KEJ A;  3HB2 P;  2QPJ A;  4L19 A;  1BUV M;  1L6J A;  2CLT A;  5BPA A;  3HDB A;  3F16 A;  5CXA A;  4GR8 A;  2ERQ A;  2Y6C A;  1GXD A;  3WV1 A;  3K7L A;  4XM6 A;  3LQ0 A;  2J83 A;  4FXQ A;  1BM6 A;  4FVL A;  1G05 A;  3V96 B;  1OM6 A;  4J4M A;  1R54 A;  2RJP A;  3USN A;  4ON1 A;  4XM7 A;  3OHO A;  5CZM A;  1S4B P;  3B92 A;  5I2Z A;  1AF0 A;  4XBH A;  4Q1L A;  1ZTQ A;  4JPA A;  1R1J A;  1OM8 A;  4WKI A;  1BQO A;  1K7I A;  1KUG A;  2ERO A;  1XUD A;  1D5J A;  3RTS A;  5I0L A;  2OVX A;  3LIK A;  4IN9 A;  5L7F A;  4IJO A;  1JIZ A;  4PKU A;  4R3V A;  1IAE A;  3EDZ A;  3U1R A;  4H30 A;  2X7M A;  1YP1 A;  3DNG A;  1JAQ A;  1CAQ A;  3B8Z A;  3G42 A;  2X3A A;  1JJ9 A;  1MNC A;  3AIG A;  3F15 A;  3I7G A;  2CKI A;  1JAO A;  1EAK A;  2OW0 A;  4PKW A;  4AYK A;  1PWU A;  1H71 P;  1QIB A;  2FV5 A;  1C8T A;  1CGL A;  2W13 A;  5JMY A;  3UVC A;  4PKS A;  3L0V A;  1JAP A;  5CUH A;  2D1O A;  1BKC I;  3Q2H A;  2MLS A;  1D8F A;  1SMP A;  3ZUK A;  1XM5 A;  1O0Q A;  1CGE A;  1BKC E;  3F18 A;  1MMQ A;  456C A;  2DDY A;  3DTI A;  1HFC A;  5I12 A;  3CKI A;  4I35 A;  3EHY A;  4IUW A;  1Q3A A;  3DSL A;  5D7W A;  1EUB A;  4JA1 A;  1GKC A;  1KAP P;  1PWP A;  1PWW A;  1ZXC A;  1ZXV A;  4PKT A;  2X3B A;  1JIW P;  1XFW A;  1UTT A;  5D1T A;  3TS4 A;  1G4K A;  2OW2 A;  1QUA A;  1IAC A;  4H82 A;  1UMT A;  1RMZ A;  3LJZ A;  1Y93 A;  3N2U A;  5D1S A;  3AYK A;  3L0T A;  5D3C A;  1UMS A;  2OVZ A;  1KUK A;  5I4O A;  4PKV A;  1ND1 A;  3LE9 A;  4AIG A;  3LKA A;  1HFS A;  3LUN A;  1CQR A;  1OM7 A;  4HX3 A;  3Q2G A;  2OW1 A;  1D7X A;  1K7Q A;  1SLN A;  2XS3 A;  2O3E A;  1KUI A;  4A3W A;  2MZE A;  1IAG A;  2YUF A;  1A86 A;  2OW9 A;  2USN A;  4WF6 A;  1ZS0 A;  1QJJ A;  1GE7 A;  4ILW D;  3KWV C;  3HYG A;  3O2X A;  1ROS A;  1C3I A;  4QKZ A;  3EHX A;  3LIR A;  1JKY A;  4GWM A;  2K2G A;  1BUD A;  1XFV A;  3MA2 A;  1HOV A;  1GE6 A;  2OY4 A;  1KUH A;  3HBV P;  3LMC A;  1KUF A;  1ZP5 A;  1R1H A;  1Z3J A;  1G49 A;  1YQY A;  1B8Y A;  4GR3 A;  1FM1 A;  4H2E A;  2MZH A;  1FBL A;  2YIG A;  3K7N A;  5D2B A;  3WV2 A;  4EFS A;  2W14 A;  3AYU A;  3DTE A;  3LJT A;  1A85 A;  4I03 A;  3LJG A;  2V4B A;  2OXU A;  1HTD A;  2N8R A;  1BQQ M;  1YCM A;  1QIC A;  1PWQ A;  4PKR A;  2W0D A;  2E2D A;  1AST A;  1BIW A;  4GUY A;  2OXZ A;  4GF1 A;  3EDI A;  4ZR5 A;  1B3D A;  2L0R A;  3OHL A;  2OY2 A;  1AKL A;  2OI0 A;  2XS4 A;  2OZR A;  3VI1 A;  1OS2 A;  3I7I A;  5D1U A;  1JH1 A;  3TSK A;  1HV5 A;  3KME A;  3KRY A;  4H3X A;  2J0T A;  3LEA A;  1SLM A;  1CGF A;  1JAN A;  4GWN A;  4HMA A;  4DF9 A;  3EDG A;  1OMJ A;  3HY9 A;  4PKQ A;  1GKD A;  3TT4 A;  3LQB A;  3B2Z A;  1UTZ A;  1Y8J A;  1XFZ A;  2Z2D A;  4H76 A;  3LUM A;  3WV3 A;  1OS9 A;  2FV9 A;  3RTT A;  5LAB A;  1D8M A;  1IAD A;  1SU3 A;  1DTH A;  2DW2 A;  1G9K A;  3LK8 A;  4JIJ A;  2OXW A;  2DDF A;  4WZV A;  3EWJ A;  2RJQ A;  3NX7 A;  1BZS A;  1PWV A;  2JIH A;  2YB9 A;  1I1I P;  3DPE A;  3ZVS A;  1K7G A;  3SHI A;  1TVI A;  3DPF A;  1XAX A;  4XM8 A;  3DWB A;  1GO7 P;  1O0T A;  2JT6 A;  1USN A;  5B5O A;  1G12 A;  3ZXH A;  1BKC A;  1SAT A;  1MMB A;  1MMR A;  4L63 A;  2SRT A;  966C A;  1XUR A;  2JT5 A;  4H49 A;  1QJI A;  5B5P A;  1XFU A;  2W12 A;  3HDA P;  4AXQ A;  4XCT A;  3ELM A;  1FLS A;  1ATL A;  1Y0V A;  2I47 A;  4FU4 A;  2K9C A;  4GQL A;  3BA0 A;  1RM8 A;  2KRJ A;  4L6T A; 
#chains in the Genus database with same CATH homology
 1YOU A;  2ERP A;  2Y6D A;  3KEK A;  3P24 A;  4H1Q A;  1XFY A;  2DW1 A;  4WKE A;  1WNI A;  3F17 A;  4CTH A;  4DV8 A;  4FXY P;  2A8H A;  3EDH A;  1SRP A;  1XFX A;  1JK3 A;  1UEA A;  1GE5 A;  1XUC A;  3E8R A;  3F19 A;  4GR0 A;  5BOT A;  4JP4 A;  2MLR A;  2WO9 A;  2D1N A;  2MZI A;  3TVC A;  2E3X A;  1HY7 A;  3HBU P;  5I43 A;  3HY7 A;  3LGP A;  1MMP A;  1ZVX A;  3GBO A;  1CXV A;  2PJT A;  1KBC A;  2POJ A;  2AIG P;  3N2V A;  4G0D A;  3G5C A;  5I3M A;  3P1V A;  1IAA A;  3LIL A;  2WO8 A;  2X3C A;  4DD8 A;  3O64 A;  1CK7 A;  2W15 A;  1EB6 A;  1R55 A;  3KHI A;  4DPE A;  4JQG A;  4G9L A;  1OO9 A;  2O36 A;  1IAB A;  1AYK A;  2TCL A;  1R1I A;  5H8X A;  1C7K A;  1I73 A;  830C A;  1BSW A;  1QIA A;  1GO8 P;  3KEC A;  5BOY A;  4A7B A;  3DTK A;  4L7A A;  4WK7 A;  3F1A A;  3VTG A;  3DL1 A;  4AUO A;  2DW0 A;  1DMT A;  1J7N A;  2JSD A;  4H84 A;  2WOA A;  5L79 A;  2AYK A;  1CIZ A;  1I76 A;  2HU6 A;  2JNP A;  3KMC A;  3KEJ A;  3HB2 P;  2QPJ A;  4L19 A;  1BUV M;  1L6J A;  2CLT A;  5BPA A;  3HDB A;  3F16 A;  5CXA A;  4GR8 A;  2ERQ A;  2Y6C A;  1GXD A;  3WV1 A;  3K7L A;  4XM6 A;  3LQ0 A;  2J83 A;  4FXQ A;  1BM6 A;  4FVL A;  1G05 A;  3V96 B;  1OM6 A;  4J4M A;  1R54 A;  2RJP A;  3USN A;  4ON1 A;  4XM7 A;  3OHO A;  5CZM A;  1S4B P;  3B92 A;  5I2Z A;  1AF0 A;  4XBH A;  4Q1L A;  1ZTQ A;  4JPA A;  1R1J A;  1OM8 A;  4WKI A;  1BQO A;  1K7I A;  1KUG A;  2ERO A;  1XUD A;  1D5J A;  3RTS A;  5I0L A;  2OVX A;  3LIK A;  4IN9 A;  5L7F A;  4IJO A;  1JIZ A;  4PKU A;  4R3V A;  1IAE A;  3EDZ A;  3U1R A;  4H30 A;  2X7M A;  1YP1 A;  3DNG A;  1JAQ A;  1CAQ A;  3B8Z A;  3G42 A;  2X3A A;  1JJ9 A;  1MNC A;  3AIG A;  3F15 A;  3I7G A;  2CKI A;  1JAO A;  1EAK A;  2OW0 A;  4PKW A;  4AYK A;  1PWU A;  1H71 P;  1QIB A;  2FV5 A;  1C8T A;  1CGL A;  2W13 A;  5JMY A;  3UVC A;  4PKS A;  3L0V A;  1JAP A;  5CUH A;  2D1O A;  1BKC I;  3Q2H A;  2MLS A;  1D8F A;  1SMP A;  3ZUK A;  1O0Q A;  1CGE A;  1BKC E;  3F18 A;  1MMQ A;  456C A;  2DDY A;  3DTI A;  1HFC A;  5I12 A;  3CKI A;  4I35 A;  3EHY A;  4IUW A;  1Q3A A;  3DSL A;  5D7W A;  1EUB A;  4JA1 A;  1GKC A;  1KAP P;  1PWP A;  1PWW A;  1ZXC A;  1ZXV A;  4PKT A;  2X3B A;  1JIW P;  1XFW A;  1UTT A;  5D1T A;  3TS4 A;  1G4K A;  2OW2 A;  1QUA A;  1IAC A;  4H82 A;  1UMT A;  1RMZ A;  3LJZ A;  1Y93 A;  3N2U A;  5D1S A;  3AYK A;  3L0T A;  5D3C A;  1UMS A;  2OVZ A;  1KUK A;  5I4O A;  4PKV A;  1ND1 A;  3LE9 A;  4AIG A;  3LKA A;  1HFS A;  3LUN A;  1CQR A;  1OM7 A;  4HX3 A;  3Q2G A;  2OW1 A;  1D7X A;  1K7Q A;  1SLN A;  2XS3 A;  2O3E A;  1KUI A;  4A3W A;  2MZE A;  1IAG A;  2YUF A;  1A86 A;  2OW9 A;  2USN A;  4WF6 A;  1ZS0 A;  1QJJ A;  1GE7 A;  4ILW D;  3KWV C;  3HYG A;  3O2X A;  1ROS A;  1C3I A;  4QKZ A;  3EHX A;  3LIR A;  1JKY A;  4GWM A;  2K2G A;  1BUD A;  1XFV A;  3MA2 A;  1HOV A;  1GE6 A;  2OY4 A;  1KUH A;  3HBV P;  3LMC A;  1KUF A;  1ZP5 A;  1R1H A;  1Z3J A;  1G49 A;  1YQY A;  1B8Y A;  4GR3 A;  1FM1 A;  4H2E A;  2MZH A;  1FBL A;  2YIG A;  3K7N A;  5D2B A;  3WV2 A;  4EFS A;  2W14 A;  3AYU A;  3DTE A;  3LJT A;  1A85 A;  4I03 A;  3LJG A;  2V4B A;  2OXU A;  1HTD A;  2N8R A;  1BQQ M;  1YCM A;  1QIC A;  1PWQ A;  4PKR A;  2W0D A;  2E2D A;  1AST A;  1BIW A;  4GUY A;  2OXZ A;  4GF1 A;  3EDI A;  4ZR5 A;  1B3D A;  2L0R A;  3OHL A;  2OY2 A;  1AKL A;  2OI0 A;  2XS4 A;  2OZR A;  3VI1 A;  1OS2 A;  3I7I A;  5D1U A;  1JH1 A;  3TSK A;  1HV5 A;  3KME A;  3KRY A;  4H3X A;  2J0T A;  3LEA A;  1SLM A;  1CGF A;  1JAN A;  4GWN A;  4HMA A;  4DF9 A;  3EDG A;  1OMJ A;  3HY9 A;  4PKQ A;  1GKD A;  3TT4 A;  3LQB A;  3B2Z A;  1UTZ A;  1Y8J A;  1XFZ A;  2Z2D A;  4H76 A;  3LUM A;  3WV3 A;  1OS9 A;  2FV9 A;  3RTT A;  5LAB A;  1D8M A;  1IAD A;  1SU3 A;  1DTH A;  2DW2 A;  1G9K A;  3LK8 A;  4JIJ A;  2OXW A;  2DDF A;  4WZV A;  3EWJ A;  2RJQ A;  3NX7 A;  1BZS A;  1PWV A;  2JIH A;  2YB9 A;  1I1I P;  3DPE A;  3ZVS A;  1K7G A;  3SHI A;  3DPF A;  4XM8 A;  3DWB A;  1GO7 P;  1O0T A;  2JT6 A;  1USN A;  5B5O A;  1G12 A;  3ZXH A;  1BKC A;  1SAT A;  1MMB A;  1MMR A;  4L63 A;  2SRT A;  966C A;  1XUR A;  2JT5 A;  4H49 A;  1QJI A;  5B5P A;  1XFU A;  2W12 A;  3HDA P;  4AXQ A;  4XCT A;  3ELM A;  1FLS A;  1ATL A;  1Y0V A;  2I47 A;  4FU4 A;  2K9C A;  4GQL A;  3BA0 A;  1RM8 A;  2KRJ A;  4L6T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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