2A8HA

Crystal structure of catalytic domain of tace with thiomorpholine sulfonamide hydroxamate inhibitor
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
259
structure length
259
Chain Sequence
DPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERSN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords ADAM 17
total genus 84
structure length 259
sequence length 259
chains with identical sequence B
ec nomenclature ec 3.4.24.86: ADAM 17 endopeptidase.
pdb deposition date 2005-07-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13688 Reprolysin_5 Metallo-peptidase family M12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 2a8hA00
1B3DA 4PKSA 1C7KA 2W12A 3LEAA 4H30A 1JH1A 1IAEA 2OVXA 3BA0A 1JK3A 2POJA 1ND1A 1XUDA 2OXUA 3LILA 4H3XA 1WNIA 4HX3A 1Y93A 1JAPA 4XM7A 1Y0VA 2CLTA 4AUOA 1DMTA 3EDGA 2OW2A 3LQBA 1OO9A 2D1OA 1MMBA 5BPAA 3HY7A 3LJTA 2USNA 4H1QA 2OXWA 1ZVXA 3LE9A 4Q1LA 1JIWP 3ZVSA 1BSWA 1EUBA 1CAQA 1MNCA 5B5OA 2JSDA 3LGPA 1QICA 1AKLA 1L6JA 1Z3JA 1JKYA 3SHIA 2CKIA 2A8HA 4JA1A 1JJ9A 1XFVA 4H84A 1OM8A 2OZRA 4GWNA 1JAOA 3KEKA 1C3IA 1IABA 4FXQA 4PKRA 2MLRA 1MMRA 1BM6A 2RJQA 3G5CA 4H49A 1G05A 1KAPP 1R1IA 3DSLA 2DDFA 1GE5A 1ZXVA 2KRJA 5D3CA 4GF1A 1IAAA 2AYKA 5L7FA 4FXYP 2WOAA 4XCTA 3F18A 2OW1A 1XFUA 3DNGA 3LK8A 4G0DA 5D1UA 1OM7A 1GXDA 1JANA 1A86A 3EHXA 2JNPA 4IN9A 2K9CA 2J0TA 1Q3AA 5D2BA 3DPFA 4ILWD 2I47A 3HDAP 1ZS0A 1R1HA 1BKCA 3LJGA 2FV9A 4PKVA 1RM8A 2E3XA 4A7BA 3DWBA 4A3WA 5I43A 1CXVA 1PWVA 2DW2A 3KEJA 3LUNA 2JT5A 1RMZA 3B2ZA 2OVZA 3L0TA 4PKTA 5I12A 4ZR5A 4GR3A 3U1RA 4FVLA 1CGFA 1BKCE 4WKEA 3B8ZA 3LJZA 3G42A 1FM1A 1CGLA 1I73A 456CA 2OY2A 1G49A 4AXQA 3AIGA 4GWMA 3VTGA 3O2XA 5BOTA 4IUWA 2ERQA 1D8MA 4XM6A 1XURA 1HY7A 5B5PA 1QIAA 1R1JA 3KRYA 3LMCA 5D1SA 1A85A 4DV8A 3LIRA 4H2EA 3F19A 5L79A 3ELMA 3KECA 4JP4A 1ASTA 1S4BP 1KUFA 1ROSA 1R55A 2E2DA 2O36A 3AYUA 1PWPA 1YOUA 1OM6A 4IJOA 3V96B 3EHYA 2XS3A 1QJJA 1FLSA 1OMJA 1ZXCA 3LIKA 1OS9A 5I3MA 3Q2HA 1PWQA 2OY4A 4PKQA 3N2VA 4XBHA 2MLSA 1GKCA 4EFSA 1UTTA 2XS4A 3NX7A 4JPAA 2PJTA 2V4BA 2YB9A 2W14A 1QUAA 1CK7A 2J83A 3OHOA 3HBUP 1GE6A 3EDZA 2RJPA 4DD8A 1BUDA 3EWJA 2D1NA 1IACA 4H82A 4JQGA 1XFWA 1UTZA 4L19A 3OHLA 1B8YA 3HB2P 2X3CA 1SMPA 2W15A 2Z2DA 3ZUKA 5I2ZA 4XM8A 4CTHA 2WO9A 4DF9A 3TT4A 3WV1A 1KBCA 1XFZA 5I4OA 4AYKA 3KWVC 1SRPA 4WZVA 1JAQA 1HOVA 1YCMA 3KMEA 4GUYA 830CA 1IAGA 3B92A 4GR0A 1H71P 2AIGP 1HTDA 2FV5A 5CZMA 3E8RA 3LKAA 4GQLA 2K2GA 1UEAA 3I7IA 2EROA 1BIWA 4FU4A 2WO8A 2W0DA 3AYKA 1USNA 2YIGA 5D7WA 1SLNA 3WV3A 4JIJA 1O0TA 1BUVM 1R54A 2JIHA 1XUCA 3MA2A 3TS4A 3N2UA 1ZP5A 2DW1A 1PWUA 3VI1A 1D8FA 1GO7P 3HYGA 1GKDA 3F1AA 1D7XA 3HBVP 5JMYA 4L6TA 1PWWA 3USNA 3P1VA 4H76A 1GE7A 2HU6A 2ERPA 3I7GA 3O64A 1UMTA 1XFXA 3KHIA 1JIZA 3DL1A 4L63A 2JT6A 5CUHA 4R3VA 4J4MA 1BQOA 1O0QA 2L0RA 2QPJA 2MZHA 4GR8A 4WK7A 3F17A 4HMAA 1BQQM 2N8RA 1SATA 3UVCA 1I76A 4PKUA 1EAKA 1K7IA 1CQRA 2MZIA 1HV5A 2W13A 5H8XA 1IADA 1K7QA 5CXAA 3K7LA 2OW0A 1KUGA 3KMCA 3EDIA 3DPEA 2SRTA 1CGEA 1K7GA 1I1IP 1YQYA 5LABA 2TCLA 1G9KA 4DPEA 3RTSA 1AYKA 4I03A 3HY9A 2DDYA 3RTTA 1EB6A 2DW0A 3TSKA 4AIGA 1G4KA 3L0VA 3GBOA 2OI0A 5D1TA 1FBLA 3LQ0A 1KUKA 1C8TA 1D5JA 4I35A 4PKWA 1QJIA 2Y6CA 1CIZA 1MMPA 1SLMA 1G12A 1YP1A 1KUHA 1ZTQA 3F15A 3TVCA 1BZSA 2MZEA 1ATLA 1AF0A 1UMSA 1XFYA 2X7MA 1MMQA 4G9LA 1SU3A 1Y8JA 1J7NA 1QIBA 4WKIA 5BOYA 1GO8P 3HDBA 1HFCA 2OW9A 1BKCI 4QKZA 2X3AA 3CKIA 2OXZA 3ZXHA 1HFSA 3LUMA 3P24A 2O3EA 4ON1A 2X3BA 966CA 3WV2A 5I0LA 3K7NA 3F16A 1OS2A 3EDHA 3Q2GA 1DTHA 1KUIA 2Y6DA 4WF6A
chains in the Genus database with same CATH superfamily
1B3DA 4PKSA 1C7KA 2W12A 3LEAA 4H30A 1JH1A 1IAEA 2OVXA 3BA0A 1JK3A 2POJA 1ND1A 1XUDA 2OXUA 3LILA 4H3XA 1WNIA 4HX3A 1Y93A 1JAPA 4XM7A 1Y0VA 2CLTA 4AUOA 1DMTA 3EDGA 2OW2A 3LQBA 1OO9A 1OZ9A 2D1OA 1MMBA 5BPAA 3HY7A 3LJTA 2USNA 4H1QA 2OXWA 1ZVXA 3LE9A 4Q1LA 1JIWP 3ZVSA 1BSWA 1EUBA 1CAQA 1MNCA 5B5OA 2JSDA 3LGPA 1QICA 2YUFA 1AKLA 1L6JA 1Z3JA 1JKYA 3SHIA 2CKIA 2A8HA 4JA1A 1JJ9A 1XFVA 4H84A 1OM8A 2OZRA 4GWNA 1JAOA 3KEKA 1C3IA 1IABA 4FXQA 1XM5A 4PKRA 2MLRA 1MMRA 1BM6A 2RJQA 3G5CA 4H49A 1G05A 1KAPP 1R1IA 3DSLA 2DDFA 1GE5A 1ZXVA 2KRJA 5D3CA 4GF1A 1IAAA 2AYKA 5L7FA 4FXYP 2WOAA 4XCTA 3F18A 2OW1A 1XFUA 3DNGA 3LK8A 4G0DA 5D1UA 1OM7A 1GXDA 1JANA 1A86A 3EHXA 2JNPA 4IN9A 2K9CA 2J0TA 1Q3AA 5D2BA 3DPFA 4ILWD 2I47A 3HDAP 1ZS0A 1R1HA 1BKCA 3LJGA 2FV9A 4PKVA 1RM8A 2E3XA 4A7BA 3DWBA 4A3WA 5I43A 1CXVA 1PWVA 2DW2A 3KEJA 3LUNA 2JT5A 1RMZA 3B2ZA 2OVZA 3L0TA 4PKTA 5I12A 4ZR5A 4GR3A 3U1RA 4FVLA 1CGFA 1BKCE 4WKEA 3B8ZA 3LJZA 3G42A 1FM1A 1CGLA 1I73A 456CA 2OY2A 1G49A 4AXQA 3AIGA 4GWMA 3VTGA 3O2XA 1XAXA 5BOTA 4IUWA 2ERQA 1D8MA 4XM6A 1XURA 1HY7A 5B5PA 1QIAA 1R1JA 3KRYA 3LMCA 5D1SA 1A85A 4DV8A 3LIRA 4H2EA 3F19A 5L79A 3ELMA 3KECA 4JP4A 1ASTA 1S4BP 1KUFA 1ROSA 1R55A 2E2DA 2O36A 3AYUA 1PWPA 1YOUA 1OM6A 3DTEA 4IJOA 3V96B 3EHYA 2XS3A 1QJJA 1FLSA 1OMJA 1ZXCA 3LIKA 1OS9A 5I3MA 3Q2HA 1PWQA 2OY4A 4PKQA 3N2VA 4XBHA 2MLSA 1GKCA 4EFSA 1UTTA 2XS4A 3NX7A 4JPAA 2PJTA 2V4BA 2YB9A 2W14A 1QUAA 1CK7A 2J83A 3OHOA 3HBUP 1GE6A 3EDZA 2RJPA 4DD8A 1BUDA 3EWJA 2D1NA 1IACA 4H82A 4JQGA 1XFWA 1UTZA 4L19A 3OHLA 1B8YA 3HB2P 2X3CA 1SMPA 2W15A 2Z2DA 3ZUKA 5I2ZA 4XM8A 4CTHA 2WO9A 3DTKA 4DF9A 3TT4A 3WV1A 1KBCA 1XFZA 5I4OA 4AYKA 3KWVC 1SRPA 4WZVA 1JAQA 1HOVA 1YCMA 3KMEA 4GUYA 830CA 1IAGA 3B92A 4GR0A 1H71P 2AIGP 1HTDA 2FV5A 5CZMA 3E8RA 3LKAA 4GQLA 2K2GA 1UEAA 3I7IA 2EROA 1BIWA 4FU4A 2WO8A 2W0DA 3AYKA 1USNA 2YIGA 5D7WA 1SLNA 3WV3A 4JIJA 1O0TA 1BUVM 1R54A 2JIHA 1XUCA 3MA2A 3TS4A 3N2UA 1ZP5A 2DW1A 1PWUA 3VI1A 1D8FA 1GO7P 3HYGA 1GKDA 3F1AA 1D7XA 3HBVP 5JMYA 4L6TA 1PWWA 3USNA 3P1VA 4H76A 1GE7A 2HU6A 2ERPA 3I7GA 3O64A 1UMTA 1XFXA 3KHIA 1JIZA 3DL1A 4L63A 2JT6A 5CUHA 4R3VA 4J4MA 1BQOA 1O0QA 2L0RA 2QPJA 2MZHA 4GR8A 4WK7A 3F17A 4HMAA 1BQQM 2N8RA 1SATA 3UVCA 1I76A 4PKUA 1EAKA 1K7IA 3DTIA 4L7AA 1CQRA 2MZIA 1HV5A 2W13A 1TVIA 5H8XA 1IADA 1K7QA 5CXAA 3K7LA 2OW0A 1KUGA 3KMCA 3EDIA 3DPEA 2SRTA 1CGEA 1K7GA 1I1IP 1YQYA 5LABA 2TCLA 1G9KA 4DPEA 3RTSA 1AYKA 4I03A 3HY9A 2DDYA 3RTTA 1EB6A 2DW0A 3TSKA 4AIGA 1G4KA 3L0VA 3GBOA 2OI0A 5D1TA 1FBLA 3LQ0A 1KUKA 1C8TA 1D5JA 4I35A 4PKWA 1QJIA 2Y6CA 1CIZA 1MMPA 1SLMA 1G12A 1YP1A 1KUHA 1ZTQA 3F15A 3TVCA 1BZSA 2MZEA 1ATLA 1AF0A 1UMSA 1XFYA 2X7MA 1MMQA 4G9LA 1SU3A 1Y8JA 1J7NA 1QIBA 4WKIA 5BOYA 1GO8P 3HDBA 1HFCA 2OW9A 1BKCI 4QKZA 2X3AA 3CKIA 2OXZA 3ZXHA 1HFSA 3LUMA 3P24A 2O3EA 4ON1A 2X3BA 966CA 3WV2A 5I0LA 3K7NA 3F16A 1OS2A 3EDHA 3Q2GA 1DTHA 1KUIA 2Y6DA 4WF6A
chains in the Genus database with same CATH topology
1B3DA 4PKSA 1C7KA 2W12A 3LEAA 4H30A 1JH1A 1IAEA 2OVXA 3BA0A 1JK3A 2POJA 1ND1A 1XUDA 2OXUA 3LILA 4H3XA 1WNIA 4HX3A 1Y93A 1JAPA 4XM7A 1Y0VA 2CLTA 4AUOA 1DMTA 3EDGA 2OW2A 3LQBA 1OO9A 2D1OA 1MMBA 5BPAA 3HY7A 3LJTA 2USNA 4H1QA 2OXWA 1ZVXA 3LE9A 4Q1LA 1JIWP 3ZVSA 1BSWA 1EUBA 1CAQA 1MNCA 5B5OA 2JSDA 3LGPA 1QICA 2YUFA 1AKLA 1L6JA 1Z3JA 1JKYA 3SHIA 2CKIA 2A8HA 4JA1A 1JJ9A 1XFVA 4H84A 1OM8A 2OZRA 4GWNA 1JAOA 3KEKA 1C3IA 1IABA 4FXQA 4PKRA 2MLRA 1MMRA 1BM6A 2RJQA 3G5CA 4H49A 1G05A 1KAPP 1R1IA 3DSLA 2DDFA 1GE5A 1ZXVA 2KRJA 5D3CA 4GF1A 1IAAA 2AYKA 5L7FA 4FXYP 2WOAA 4XCTA 3F18A 2OW1A 1XFUA 3DNGA 3LK8A 4G0DA 5D1UA 1OM7A 1GXDA 1JANA 1A86A 3EHXA 2JNPA 4IN9A 2K9CA 2J0TA 1Q3AA 5D2BA 3DPFA 4ILWD 2I47A 3HDAP 1ZS0A 1R1HA 1BKCA 3LJGA 2FV9A 4PKVA 1RM8A 2E3XA 4A7BA 3DWBA 4A3WA 5I43A 1CXVA 1PWVA 2DW2A 3KEJA 3LUNA 2JT5A 1RMZA 3B2ZA 2OVZA 3L0TA 4PKTA 5I12A 4ZR5A 4GR3A 3U1RA 4FVLA 1CGFA 1BKCE 4WKEA 3B8ZA 3LJZA 3G42A 1FM1A 1CGLA 1I73A 456CA 2OY2A 1G49A 4AXQA 3AIGA 4GWMA 3VTGA 3O2XA 5BOTA 4IUWA 2ERQA 1D8MA 4XM6A 1XURA 1HY7A 5B5PA 1QIAA 1R1JA 3KRYA 3LMCA 5D1SA 1A85A 4DV8A 3LIRA 4H2EA 3F19A 5L79A 3ELMA 3KECA 4JP4A 1ASTA 1S4BP 1KUFA 1ROSA 1R55A 2E2DA 2O36A 3AYUA 1PWPA 1YOUA 1OM6A 3DTEA 4IJOA 3V96B 3EHYA 2XS3A 1QJJA 1FLSA 1OMJA 1ZXCA 3LIKA 1OS9A 5I3MA 3Q2HA 1PWQA 2OY4A 4PKQA 3N2VA 4XBHA 2MLSA 1GKCA 4EFSA 1UTTA 2XS4A 3NX7A 4JPAA 2PJTA 2V4BA 2YB9A 2W14A 1QUAA 1CK7A 2J83A 3OHOA 3HBUP 1GE6A 3EDZA 2RJPA 4DD8A 1BUDA 3EWJA 2D1NA 1IACA 4H82A 4JQGA 1XFWA 1UTZA 4L19A 3OHLA 1B8YA 3HB2P 2X3CA 1SMPA 2W15A 2Z2DA 3ZUKA 5I2ZA 4XM8A 4CTHA 2WO9A 3DTKA 4DF9A 3TT4A 3WV1A 1KBCA 1XFZA 5I4OA 4AYKA 3KWVC 1SRPA 4WZVA 1JAQA 1HOVA 1YCMA 3KMEA 4GUYA 830CA 1IAGA 3B92A 4GR0A 1H71P 2AIGP 1HTDA 2FV5A 5CZMA 3E8RA 3LKAA 4GQLA 2K2GA 1UEAA 3I7IA 2EROA 1BIWA 4FU4A 2WO8A 2W0DA 3AYKA 1USNA 2YIGA 5D7WA 1SLNA 3WV3A 4JIJA 1O0TA 1BUVM 1R54A 2JIHA 1XUCA 3MA2A 3TS4A 3N2UA 1ZP5A 2DW1A 1PWUA 3VI1A 1D8FA 1GO7P 3HYGA 1GKDA 3F1AA 1D7XA 3HBVP 5JMYA 4L6TA 1PWWA 3USNA 3P1VA 4H76A 1GE7A 2HU6A 2ERPA 3I7GA 3O64A 1UMTA 1XFXA 3KHIA 1JIZA 3DL1A 4L63A 2JT6A 5CUHA 4R3VA 4J4MA 1BQOA 1O0QA 2L0RA 2QPJA 2MZHA 4GR8A 4WK7A 3F17A 4HMAA 1BQQM 2N8RA 1SATA 3UVCA 1I76A 4PKUA 1EAKA 1K7IA 3DTIA 4L7AA 1CQRA 2MZIA 1HV5A 2W13A 5H8XA 1IADA 1K7QA 5CXAA 3K7LA 2OW0A 1KUGA 3KMCA 3EDIA 3DPEA 2SRTA 1CGEA 1K7GA 1I1IP 1YQYA 5LABA 2TCLA 1G9KA 4DPEA 3RTSA 1AYKA 4I03A 3HY9A 2DDYA 3RTTA 1EB6A 2DW0A 3TSKA 4AIGA 1G4KA 3L0VA 3GBOA 2OI0A 5D1TA 1FBLA 3LQ0A 1KUKA 1C8TA 1D5JA 4I35A 4PKWA 1QJIA 2Y6CA 1CIZA 1MMPA 1SLMA 1G12A 1YP1A 1KUHA 1ZTQA 3F15A 3TVCA 1BZSA 2MZEA 1ATLA 1AF0A 1UMSA 1XFYA 2X7MA 1MMQA 4G9LA 1SU3A 1Y8JA 1J7NA 1QIBA 4WKIA 5BOYA 1GO8P 3HDBA 1HFCA 2OW9A 1BKCI 4QKZA 2X3AA 3CKIA 2OXZA 3ZXHA 1HFSA 3LUMA 3P24A 2O3EA 4ON1A 2X3BA 966CA 3WV2A 5I0LA 3K7NA 3F16A 1OS2A 3EDHA 3Q2GA 1DTHA 1KUIA 2Y6DA 4WF6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1B3D A;  4PKS A;  1C7K A;  2W12 A;  3LEA A;  4H30 A;  1JH1 A;  1IAE A;  2OVX A;  3BA0 A;  1JK3 A;  2POJ A;  1ND1 A;  1XUD A;  2OXU A;  3LIL A;  4H3X A;  1WNI A;  4HX3 A;  1Y93 A;  1JAP A;  4XM7 A;  1Y0V A;  2CLT A;  4AUO A;  1DMT A;  3EDG A;  2OW2 A;  3LQB A;  1OO9 A;  2D1O A;  1MMB A;  5BPA A;  3HY7 A;  3LJT A;  2USN A;  4H1Q A;  2OXW A;  1ZVX A;  3LE9 A;  4Q1L A;  1JIW P;  3ZVS A;  1BSW A;  1EUB A;  1CAQ A;  1MNC A;  5B5O A;  2JSD A;  3LGP A;  1QIC A;  1AKL A;  1L6J A;  1Z3J A;  1JKY A;  3SHI A;  2CKI A;  2A8H A;  4JA1 A;  1JJ9 A;  1XFV A;  4H84 A;  1OM8 A;  2OZR A;  4GWN A;  1JAO A;  3KEK A;  1C3I A;  1IAB A;  4FXQ A;  4PKR A;  2MLR A;  1MMR A;  1BM6 A;  2RJQ A;  3G5C A;  4H49 A;  1G05 A;  1KAP P;  1R1I A;  3DSL A;  2DDF A;  1GE5 A;  1ZXV A;  2KRJ A;  5D3C A;  4GF1 A;  1IAA A;  2AYK A;  5L7F A;  4FXY P;  2WOA A;  4XCT A;  3F18 A;  2OW1 A;  1XFU A;  3DNG A;  3LK8 A;  4G0D A;  5D1U A;  1OM7 A;  1GXD A;  1JAN A;  1A86 A;  3EHX A;  2JNP A;  4IN9 A;  2K9C A;  2J0T A;  1Q3A A;  5D2B A;  3DPF A;  4ILW D;  2I47 A;  3HDA P;  1ZS0 A;  1R1H A;  1BKC A;  3LJG A;  2FV9 A;  4PKV A;  1RM8 A;  2E3X A;  4A7B A;  3DWB A;  4A3W A;  5I43 A;  1CXV A;  1PWV A;  2DW2 A;  3KEJ A;  3LUN A;  2JT5 A;  1RMZ A;  3B2Z A;  2OVZ A;  3L0T A;  4PKT A;  5I12 A;  4ZR5 A;  4GR3 A;  3U1R A;  4FVL A;  1CGF A;  1BKC E;  4WKE A;  3B8Z A;  3LJZ A;  3G42 A;  1FM1 A;  1CGL A;  1I73 A;  456C A;  2OY2 A;  1G49 A;  4AXQ A;  3AIG A;  4GWM A;  3VTG A;  3O2X A;  5BOT A;  4IUW A;  2ERQ A;  1D8M A;  4XM6 A;  1XUR A;  1HY7 A;  5B5P A;  1QIA A;  1R1J A;  3KRY A;  3LMC A;  5D1S A;  1A85 A;  4DV8 A;  3LIR A;  4H2E A;  3F19 A;  5L79 A;  3ELM A;  3KEC A;  4JP4 A;  1AST A;  1S4B P;  1KUF A;  1ROS A;  1R55 A;  2E2D A;  2O36 A;  3AYU A;  1PWP A;  1YOU A;  1OM6 A;  4IJO A;  3V96 B;  3EHY A;  2XS3 A;  1QJJ A;  1FLS A;  1OMJ A;  1ZXC A;  3LIK A;  1OS9 A;  5I3M A;  3Q2H A;  1PWQ A;  2OY4 A;  4PKQ A;  3N2V A;  4XBH A;  2MLS A;  1GKC A;  4EFS A;  1UTT A;  2XS4 A;  3NX7 A;  4JPA A;  2PJT A;  2V4B A;  2YB9 A;  2W14 A;  1QUA A;  1CK7 A;  2J83 A;  3OHO A;  3HBU P;  1GE6 A;  3EDZ A;  2RJP A;  4DD8 A;  1BUD A;  3EWJ A;  2D1N A;  1IAC A;  4H82 A;  4JQG A;  1XFW A;  1UTZ A;  4L19 A;  3OHL A;  1B8Y A;  3HB2 P;  2X3C A;  1SMP A;  2W15 A;  2Z2D A;  3ZUK A;  5I2Z A;  4XM8 A;  4CTH A;  2WO9 A;  4DF9 A;  3TT4 A;  3WV1 A;  1KBC A;  1XFZ A;  5I4O A;  4AYK A;  3KWV C;  1SRP A;  4WZV A;  1JAQ A;  1HOV A;  1YCM A;  3KME A;  4GUY A;  830C A;  1IAG A;  3B92 A;  4GR0 A;  1H71 P;  2AIG P;  1HTD A;  2FV5 A;  5CZM A;  3E8R A;  3LKA A;  4GQL A;  2K2G A;  1UEA A;  3I7I A;  2ERO A;  1BIW A;  4FU4 A;  2WO8 A;  2W0D A;  3AYK A;  1USN A;  2YIG A;  5D7W A;  1SLN A;  3WV3 A;  4JIJ A;  1O0T A;  1BUV M;  1R54 A;  2JIH A;  1XUC A;  3MA2 A;  3TS4 A;  3N2U A;  1ZP5 A;  2DW1 A;  1PWU A;  3VI1 A;  1D8F A;  1GO7 P;  3HYG A;  1GKD A;  3F1A A;  1D7X A;  3HBV P;  5JMY A;  4L6T A;  1PWW A;  3USN A;  3P1V A;  4H76 A;  1GE7 A;  2HU6 A;  2ERP A;  3I7G A;  3O64 A;  1UMT A;  1XFX A;  3KHI A;  1JIZ A;  3DL1 A;  4L63 A;  2JT6 A;  5CUH A;  4R3V A;  4J4M A;  1BQO A;  1O0Q A;  2L0R A;  2QPJ A;  2MZH A;  4GR8 A;  4WK7 A;  3F17 A;  4HMA A;  1BQQ M;  2N8R A;  1SAT A;  3UVC A;  1I76 A;  4PKU A;  1EAK A;  1K7I A;  1CQR A;  2MZI A;  1HV5 A;  2W13 A;  5H8X A;  1IAD A;  1K7Q A;  5CXA A;  3K7L A;  2OW0 A;  1KUG A;  3KMC A;  3EDI A;  3DPE A;  2SRT A;  1CGE A;  1K7G A;  1I1I P;  1YQY A;  5LAB A;  2TCL A;  1G9K A;  4DPE A;  3RTS A;  1AYK A;  4I03 A;  3HY9 A;  2DDY A;  3RTT A;  1EB6 A;  2DW0 A;  3TSK A;  4AIG A;  1G4K A;  3L0V A;  3GBO A;  2OI0 A;  5D1T A;  1FBL A;  3LQ0 A;  1KUK A;  1C8T A;  1D5J A;  4I35 A;  4PKW A;  1QJI A;  2Y6C A;  1CIZ A;  1MMP A;  1SLM A;  1G12 A;  1YP1 A;  1KUH A;  1ZTQ A;  3F15 A;  3TVC A;  1BZS A;  2MZE A;  1ATL A;  1AF0 A;  1UMS A;  1XFY A;  2X7M A;  1MMQ A;  4G9L A;  1SU3 A;  1Y8J A;  1J7N A;  1QIB A;  4WKI A;  5BOY A;  1GO8 P;  3HDB A;  1HFC A;  2OW9 A;  1BKC I;  4QKZ A;  2X3A A;  3CKI A;  2OXZ A;  3ZXH A;  1HFS A;  3LUM A;  3P24 A;  2O3E A;  4ON1 A;  2X3B A;  966C A;  3WV2 A;  5I0L A;  3K7N A;  3F16 A;  1OS2 A;  3EDH A;  3Q2G A;  1DTH A;  1KUI A;  2Y6D A;  4WF6 A; 
#chains in the Genus database with same CATH topology
 1B3D A;  4PKS A;  1C7K A;  2W12 A;  3LEA A;  4H30 A;  1JH1 A;  1IAE A;  2OVX A;  3BA0 A;  1JK3 A;  2POJ A;  1ND1 A;  1XUD A;  2OXU A;  3LIL A;  4H3X A;  1WNI A;  4HX3 A;  1Y93 A;  1JAP A;  4XM7 A;  1Y0V A;  2CLT A;  4AUO A;  1DMT A;  3EDG A;  2OW2 A;  3LQB A;  1OO9 A;  1OZ9 A;  2D1O A;  1MMB A;  5BPA A;  3HY7 A;  3LJT A;  2USN A;  4H1Q A;  2OXW A;  1ZVX A;  3LE9 A;  4Q1L A;  1JIW P;  3ZVS A;  1BSW A;  1EUB A;  1CAQ A;  1MNC A;  5B5O A;  2JSD A;  3LGP A;  1QIC A;  2YUF A;  1AKL A;  1L6J A;  1Z3J A;  1JKY A;  3SHI A;  2CKI A;  2A8H A;  4JA1 A;  1JJ9 A;  1XFV A;  4H84 A;  1OM8 A;  2OZR A;  4GWN A;  1JAO A;  3KEK A;  1C3I A;  1IAB A;  4FXQ A;  1XM5 A;  4PKR A;  2MLR A;  1MMR A;  1BM6 A;  2RJQ A;  3G5C A;  4H49 A;  1G05 A;  1KAP P;  1R1I A;  3DSL A;  2DDF A;  1GE5 A;  1ZXV A;  2KRJ A;  5D3C A;  4GF1 A;  1IAA A;  2AYK A;  5L7F A;  4FXY P;  2WOA A;  4XCT A;  3F18 A;  2OW1 A;  1XFU A;  3DNG A;  3LK8 A;  4G0D A;  5D1U A;  1OM7 A;  1GXD A;  1JAN A;  1A86 A;  3EHX A;  2JNP A;  4IN9 A;  2K9C A;  2J0T A;  1Q3A A;  5D2B A;  3DPF A;  4ILW D;  2I47 A;  3HDA P;  1ZS0 A;  1R1H A;  1BKC A;  3LJG A;  2FV9 A;  4PKV A;  1RM8 A;  2E3X A;  4A7B A;  3DWB A;  4A3W A;  5I43 A;  1CXV A;  1PWV A;  2DW2 A;  3KEJ A;  3LUN A;  2JT5 A;  1RMZ A;  3B2Z A;  2OVZ A;  3L0T A;  4PKT A;  5I12 A;  4ZR5 A;  4GR3 A;  3U1R A;  4FVL A;  1CGF A;  1BKC E;  4WKE A;  3B8Z A;  3LJZ A;  3G42 A;  1FM1 A;  1CGL A;  1I73 A;  456C A;  2OY2 A;  1G49 A;  4AXQ A;  3AIG A;  4GWM A;  3VTG A;  3O2X A;  1XAX A;  5BOT A;  4IUW A;  2ERQ A;  1D8M A;  4XM6 A;  1XUR A;  1HY7 A;  5B5P A;  1QIA A;  1R1J A;  3KRY A;  3LMC A;  5D1S A;  1A85 A;  4DV8 A;  3LIR A;  4H2E A;  3F19 A;  5L79 A;  3ELM A;  3KEC A;  4JP4 A;  1AST A;  1S4B P;  1KUF A;  1ROS A;  1R55 A;  2E2D A;  2O36 A;  3AYU A;  1PWP A;  1YOU A;  1OM6 A;  3DTE A;  4IJO A;  3V96 B;  3EHY A;  2XS3 A;  1QJJ A;  1FLS A;  1OMJ A;  1ZXC A;  3LIK A;  1OS9 A;  5I3M A;  3Q2H A;  1PWQ A;  2OY4 A;  4PKQ A;  3N2V A;  4XBH A;  2MLS A;  1GKC A;  4EFS A;  1UTT A;  2XS4 A;  3NX7 A;  4JPA A;  2PJT A;  2V4B A;  2YB9 A;  2W14 A;  1QUA A;  1CK7 A;  2J83 A;  3OHO A;  3HBU P;  1GE6 A;  3EDZ A;  2RJP A;  4DD8 A;  1BUD A;  3EWJ A;  2D1N A;  1IAC A;  4H82 A;  4JQG A;  1XFW A;  1UTZ A;  4L19 A;  3OHL A;  1B8Y A;  3HB2 P;  2X3C A;  1SMP A;  2W15 A;  2Z2D A;  3ZUK A;  5I2Z A;  4XM8 A;  4CTH A;  2WO9 A;  3DTK A;  4DF9 A;  3TT4 A;  3WV1 A;  1KBC A;  1XFZ A;  5I4O A;  4AYK A;  3KWV C;  1SRP A;  4WZV A;  1JAQ A;  1HOV A;  1YCM A;  3KME A;  4GUY A;  830C A;  1IAG A;  3B92 A;  4GR0 A;  1H71 P;  2AIG P;  1HTD A;  2FV5 A;  5CZM A;  3E8R A;  3LKA A;  4GQL A;  2K2G A;  1UEA A;  3I7I A;  2ERO A;  1BIW A;  4FU4 A;  2WO8 A;  2W0D A;  3AYK A;  1USN A;  2YIG A;  5D7W A;  1SLN A;  3WV3 A;  4JIJ A;  1O0T A;  1BUV M;  1R54 A;  2JIH A;  1XUC A;  3MA2 A;  3TS4 A;  3N2U A;  1ZP5 A;  2DW1 A;  1PWU A;  3VI1 A;  1D8F A;  1GO7 P;  3HYG A;  1GKD A;  3F1A A;  1D7X A;  3HBV P;  5JMY A;  4L6T A;  1PWW A;  3USN A;  3P1V A;  4H76 A;  1GE7 A;  2HU6 A;  2ERP A;  3I7G A;  3O64 A;  1UMT A;  1XFX A;  3KHI A;  1JIZ A;  3DL1 A;  4L63 A;  2JT6 A;  5CUH A;  4R3V A;  4J4M A;  1BQO A;  1O0Q A;  2L0R A;  2QPJ A;  2MZH A;  4GR8 A;  4WK7 A;  3F17 A;  4HMA A;  1BQQ M;  2N8R A;  1SAT A;  3UVC A;  1I76 A;  4PKU A;  1EAK A;  1K7I A;  3DTI A;  4L7A A;  1CQR A;  2MZI A;  1HV5 A;  2W13 A;  1TVI A;  5H8X A;  1IAD A;  1K7Q A;  5CXA A;  3K7L A;  2OW0 A;  1KUG A;  3KMC A;  3EDI A;  3DPE A;  2SRT A;  1CGE A;  1K7G A;  1I1I P;  1YQY A;  5LAB A;  2TCL A;  1G9K A;  4DPE A;  3RTS A;  1AYK A;  4I03 A;  3HY9 A;  2DDY A;  3RTT A;  1EB6 A;  2DW0 A;  3TSK A;  4AIG A;  1G4K A;  3L0V A;  3GBO A;  2OI0 A;  5D1T A;  1FBL A;  3LQ0 A;  1KUK A;  1C8T A;  1D5J A;  4I35 A;  4PKW A;  1QJI A;  2Y6C A;  1CIZ A;  1MMP A;  1SLM A;  1G12 A;  1YP1 A;  1KUH A;  1ZTQ A;  3F15 A;  3TVC A;  1BZS A;  2MZE A;  1ATL A;  1AF0 A;  1UMS A;  1XFY A;  2X7M A;  1MMQ A;  4G9L A;  1SU3 A;  1Y8J A;  1J7N A;  1QIB A;  4WKI A;  5BOY A;  1GO8 P;  3HDB A;  1HFC A;  2OW9 A;  1BKC I;  4QKZ A;  2X3A A;  3CKI A;  2OXZ A;  3ZXH A;  1HFS A;  3LUM A;  3P24 A;  2O3E A;  4ON1 A;  2X3B A;  966C A;  3WV2 A;  5I0L A;  3K7N A;  3F16 A;  1OS2 A;  3EDH A;  3Q2G A;  1DTH A;  1KUI A;  2Y6D A;  4WF6 A; 
#chains in the Genus database with same CATH homology
 1B3D A;  4PKS A;  1C7K A;  2W12 A;  3LEA A;  4H30 A;  1JH1 A;  1IAE A;  2OVX A;  3BA0 A;  1JK3 A;  2POJ A;  1ND1 A;  1XUD A;  2OXU A;  3LIL A;  4H3X A;  1WNI A;  4HX3 A;  1Y93 A;  1JAP A;  4XM7 A;  1Y0V A;  2CLT A;  4AUO A;  1DMT A;  3EDG A;  2OW2 A;  3LQB A;  1OO9 A;  2D1O A;  1MMB A;  5BPA A;  3HY7 A;  3LJT A;  2USN A;  4H1Q A;  2OXW A;  1ZVX A;  3LE9 A;  4Q1L A;  1JIW P;  3ZVS A;  1BSW A;  1EUB A;  1CAQ A;  1MNC A;  5B5O A;  2JSD A;  3LGP A;  1QIC A;  2YUF A;  1AKL A;  1L6J A;  1Z3J A;  1JKY A;  3SHI A;  2CKI A;  2A8H A;  4JA1 A;  1JJ9 A;  1XFV A;  4H84 A;  1OM8 A;  2OZR A;  4GWN A;  1JAO A;  3KEK A;  1C3I A;  1IAB A;  4FXQ A;  4PKR A;  2MLR A;  1MMR A;  1BM6 A;  2RJQ A;  3G5C A;  4H49 A;  1G05 A;  1KAP P;  1R1I A;  3DSL A;  2DDF A;  1GE5 A;  1ZXV A;  2KRJ A;  5D3C A;  4GF1 A;  1IAA A;  2AYK A;  5L7F A;  4FXY P;  2WOA A;  4XCT A;  3F18 A;  2OW1 A;  1XFU A;  3DNG A;  3LK8 A;  4G0D A;  5D1U A;  1OM7 A;  1GXD A;  1JAN A;  1A86 A;  3EHX A;  2JNP A;  4IN9 A;  2K9C A;  2J0T A;  1Q3A A;  5D2B A;  3DPF A;  4ILW D;  2I47 A;  3HDA P;  1ZS0 A;  1R1H A;  1BKC A;  3LJG A;  2FV9 A;  4PKV A;  1RM8 A;  2E3X A;  4A7B A;  3DWB A;  4A3W A;  5I43 A;  1CXV A;  1PWV A;  2DW2 A;  3KEJ A;  3LUN A;  2JT5 A;  1RMZ A;  3B2Z A;  2OVZ A;  3L0T A;  4PKT A;  5I12 A;  4ZR5 A;  4GR3 A;  3U1R A;  4FVL A;  1CGF A;  1BKC E;  4WKE A;  3B8Z A;  3LJZ A;  3G42 A;  1FM1 A;  1CGL A;  1I73 A;  456C A;  2OY2 A;  1G49 A;  4AXQ A;  3AIG A;  4GWM A;  3VTG A;  3O2X A;  5BOT A;  4IUW A;  2ERQ A;  1D8M A;  4XM6 A;  1XUR A;  1HY7 A;  5B5P A;  1QIA A;  1R1J A;  3KRY A;  3LMC A;  5D1S A;  1A85 A;  4DV8 A;  3LIR A;  4H2E A;  3F19 A;  5L79 A;  3ELM A;  3KEC A;  4JP4 A;  1AST A;  1S4B P;  1KUF A;  1ROS A;  1R55 A;  2E2D A;  2O36 A;  3AYU A;  1PWP A;  1YOU A;  1OM6 A;  3DTE A;  4IJO A;  3V96 B;  3EHY A;  2XS3 A;  1QJJ A;  1FLS A;  1OMJ A;  1ZXC A;  3LIK A;  1OS9 A;  5I3M A;  3Q2H A;  1PWQ A;  2OY4 A;  4PKQ A;  3N2V A;  4XBH A;  2MLS A;  1GKC A;  4EFS A;  1UTT A;  2XS4 A;  3NX7 A;  4JPA A;  2PJT A;  2V4B A;  2YB9 A;  2W14 A;  1QUA A;  1CK7 A;  2J83 A;  3OHO A;  3HBU P;  1GE6 A;  3EDZ A;  2RJP A;  4DD8 A;  1BUD A;  3EWJ A;  2D1N A;  1IAC A;  4H82 A;  4JQG A;  1XFW A;  1UTZ A;  4L19 A;  3OHL A;  1B8Y A;  3HB2 P;  2X3C A;  1SMP A;  2W15 A;  2Z2D A;  3ZUK A;  5I2Z A;  4XM8 A;  4CTH A;  2WO9 A;  3DTK A;  4DF9 A;  3TT4 A;  3WV1 A;  1KBC A;  1XFZ A;  5I4O A;  4AYK A;  3KWV C;  1SRP A;  4WZV A;  1JAQ A;  1HOV A;  1YCM A;  3KME A;  4GUY A;  830C A;  1IAG A;  3B92 A;  4GR0 A;  1H71 P;  2AIG P;  1HTD A;  2FV5 A;  5CZM A;  3E8R A;  3LKA A;  4GQL A;  2K2G A;  1UEA A;  3I7I A;  2ERO A;  1BIW A;  4FU4 A;  2WO8 A;  2W0D A;  3AYK A;  1USN A;  2YIG A;  5D7W A;  1SLN A;  3WV3 A;  4JIJ A;  1O0T A;  1BUV M;  1R54 A;  2JIH A;  1XUC A;  3MA2 A;  3TS4 A;  3N2U A;  1ZP5 A;  2DW1 A;  1PWU A;  3VI1 A;  1D8F A;  1GO7 P;  3HYG A;  1GKD A;  3F1A A;  1D7X A;  3HBV P;  5JMY A;  4L6T A;  1PWW A;  3USN A;  3P1V A;  4H76 A;  1GE7 A;  2HU6 A;  2ERP A;  3I7G A;  3O64 A;  1UMT A;  1XFX A;  3KHI A;  1JIZ A;  3DL1 A;  4L63 A;  2JT6 A;  5CUH A;  4R3V A;  4J4M A;  1BQO A;  1O0Q A;  2L0R A;  2QPJ A;  2MZH A;  4GR8 A;  4WK7 A;  3F17 A;  4HMA A;  1BQQ M;  2N8R A;  1SAT A;  3UVC A;  1I76 A;  4PKU A;  1EAK A;  1K7I A;  3DTI A;  4L7A A;  1CQR A;  2MZI A;  1HV5 A;  2W13 A;  5H8X A;  1IAD A;  1K7Q A;  5CXA A;  3K7L A;  2OW0 A;  1KUG A;  3KMC A;  3EDI A;  3DPE A;  2SRT A;  1CGE A;  1K7G A;  1I1I P;  1YQY A;  5LAB A;  2TCL A;  1G9K A;  4DPE A;  3RTS A;  1AYK A;  4I03 A;  3HY9 A;  2DDY A;  3RTT A;  1EB6 A;  2DW0 A;  3TSK A;  4AIG A;  1G4K A;  3L0V A;  3GBO A;  2OI0 A;  5D1T A;  1FBL A;  3LQ0 A;  1KUK A;  1C8T A;  1D5J A;  4I35 A;  4PKW A;  1QJI A;  2Y6C A;  1CIZ A;  1MMP A;  1SLM A;  1G12 A;  1YP1 A;  1KUH A;  1ZTQ A;  3F15 A;  3TVC A;  1BZS A;  2MZE A;  1ATL A;  1AF0 A;  1UMS A;  1XFY A;  2X7M A;  1MMQ A;  4G9L A;  1SU3 A;  1Y8J A;  1J7N A;  1QIB A;  4WKI A;  5BOY A;  1GO8 P;  3HDB A;  1HFC A;  2OW9 A;  1BKC I;  4QKZ A;  2X3A A;  3CKI A;  2OXZ A;  3ZXH A;  1HFS A;  3LUM A;  3P24 A;  2O3E A;  4ON1 A;  2X3B A;  966C A;  3WV2 A;  5I0L A;  3K7N A;  3F16 A;  1OS2 A;  3EDH A;  3Q2G A;  1DTH A;  1KUI A;  2Y6D A;  4WF6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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