2HU6A

Crystal structure of human mmp-12 in complex with acetohydroxamic acid and a bicyclic inhibitor
Total Genus 42
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
42
sequence length
158
structure length
158
Chain Sequence
GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Homo sapiens
publication title Synthesis of bicyclic molecular scaffolds (BTAa): an investigation towards new selective MMP-12 inhibitors.
pubmed doi rcsb
molecule keywords Macrophage metalloelastase
total genus 42
structure length 158
sequence length 158
ec nomenclature ec 3.4.24.65: Macrophage elastase.
pdb deposition date 2006-07-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00413 Peptidase_M10 Matrixin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 2hu6A00
1YQYA 4JP4A 1R55A 2W15A 1QJJA 3LILA 4AYKA 5BPAA 3P1VA 4H49A 1C8TA 3ZUKA 4A3WA 2HU6A 1EB6A 3HBUP 2MZEA 2OY4A 1CQRA 1Y8JA 1GKCA 4HX3A 3LUNA 1ZXCA 2ERPA 2FV5A 2X3BA 1I1IP 3N2UA 3ZXHA 5I3MA 1KBCA 2TCLA 1HFSA 3RTSA 3V96B 1CIZA 2OW9A 2DDFA 1GO8P 4PKRA 1ASTA 3AYUA 2OXZA 830CA 2Z2DA 3HDAP 1SU3A 3LEAA 4GR3A 1BUDA 3I7GA 1B3DA 3TSKA 2D1OA 4G9LA 2FV9A 4H3XA 1JANA 1SLNA 2DW0A 1EAKA 3NX7A 5D2BA 4A7BA 2W13A 3OHOA 1D5JA 2YIGA 4AXQA 1OS9A 1Y0VA 2I47A 4IUWA 3DPFA 1OM6A 3VI1A 4AUOA 3LGPA 3LQ0A 2WO8A 2L0RA 5BOYA 1I76A 5H8XA 3EHXA 1K7IA 3B2ZA 5I2ZA 2OW1A 1QUAA 4XM7A 2D1NA 1A86A 3DPEA 1IADA 1JIZA 4JQGA 4FXYP 4L19A 2J0TA 4FU4A 2YB9A 3HBVP 4I03A 2ERQA 2Y6CA 1BZSA 3F15A 1BIWA 3B92A 1HTDA 2X7MA 4WK7A 1GE6A 4WKIA 1R1HA 2DW2A 1JIWP 4XM6A 1SLMA 1G05A 1SRPA 2RJPA 3EDZA 3RTTA 3UVCA 3KWVC 1KUGA 3OHLA 4PKWA 2J83A 1ZXVA 1KAPP 5L7FA 2X3CA 4XBHA 1QIBA 2WO9A 4DPEA 2N8RA 1BKCE 1RMZA 1YOUA 4FXQA 3K7LA 3TS4A 1GO7P 1ROSA 4L63A 1BUVM 1DMTA 4DD8A 3LJGA 3DSLA 5JMYA 2OVZA 1O0TA 1S4BP 1O0QA 1L6JA 4XM8A 4G0DA 1ATLA 1YP1A 2OY2A 3L0TA 3GBOA 1JKYA 5CZMA 3HB2P 1G9KA 5CXAA 1HOVA 2Y6DA 3VTGA 1UEAA 1G49A 3LUMA 1SMPA 2K2GA 4QKZA 1D8MA 5L79A 5I43A 4WKEA 1CXVA 4CTHA 4JA1A 2USNA 3KEKA 1PWWA 1AKLA 1BQQM 1KUIA 1KUFA 4WF6A 2XS4A 2O36A 2K9CA 3CKIA 2MLSA 3BA0A 3F16A 2OVXA 1CGFA 2POJA 5D1SA 2W12A 4GWNA 1MMPA 1JH1A 1RM8A 2O3EA 1CAQA 1C3IA 3HY7A 2W0DA 3AIGA 4DF9A 2V4BA 1UTZA 1A85A 2MZHA 3WV1A 1AF0A 1OS2A 3P24A 1IACA 3O2XA 1XURA 1D8FA 3WV2A 1MNCA 1JK3A 3HYGA 3DNGA 1R1JA 1DTHA 1ZVXA 2CLTA 2CKIA 5B5OA 2DDYA 1ZTQA 1K7GA 1XUDA 3WV3A 1XFVA 1UMSA 1XFYA 3LJTA 2OZRA 1OO9A 1Q3AA 3KRYA 1CGEA 1MMBA 4H30A 4ZR5A 1HV5A 4IN9A 1IABA 3G5CA 2OXWA 3F18A 1PWVA 4GF1A 3LMCA 5B5PA 1J7NA 1BKCA 1BSWA 3LKAA 3KEJA 4H1QA 1IAAA 1GKDA 3LIKA 1OM7A 4XCTA 2JSDA 1HFCA 4H2EA 4Q1LA 3Q2GA 4PKSA 3L0VA 5D3CA 2JNPA 1MMQA 5D1UA 2QPJA 1B8YA 4EFSA 5D7WA 4I35A 1G4KA 3I7IA 4PKUA 2XS3A 5I4OA 3KHIA 4PKQA 1GE7A 3K7NA 4ILWD 3LK8A 1PWUA 1BKCI 3HY9A 5BOTA 1KUKA 1ZS0A 2OI0A 1QICA 1JJ9A 4R3VA 3MA2A 1IAGA 1JAOA 3USNA 3E8RA 3ELMA 1XUCA 4H82A 4L6TA 1XFWA 4PKTA 2PJTA 3F17A 3EDHA 3LQBA 1R54A 4J4MA 1PWPA 3U1RA 1YCMA 3LIRA 1JAPA 2AIGP 1XFXA 2OXUA 4JPAA 2RJQA 5I0LA 1JAQA 4WZVA 3DWBA 3F1AA 5CUHA 4DV8A 966CA 2E3XA 5D1TA 4FVLA 2OW0A 2JT5A 1ZP5A 3B8ZA 4IJOA 3G42A 4GR8A 3AYKA 1H71P 2WOAA 3KECA 4AIGA 4H84A 2DW1A 1GE5A 3EDGA 3EDIA 2EROA 4JIJA 2E2DA 3EHYA 1ND1A 4GUYA 4GWMA 3SHIA 4H76A 2AYKA 1Z3JA 1HY7A 1IAEA 3Q2HA 1GXDA 3EWJA 1G12A 1QJIA 1I73A 3N2VA 4GR0A 4ON1A 2JT6A 3TVCA 3KMCA 1CK7A 3LE9A 2OW2A 1R1IA 2W14A 1WNIA 2SRTA 1Y93A 3F19A 2KRJA 1EUBA 2MZIA 1UTTA 1MMRA 2JIHA 1FBLA 5LABA 3TT4A 2X3AA 3O64A 2MLRA 4GQLA 1CGLA 1USNA 2A8HA 1C7KA 4PKVA 1BQOA 1D7XA 1PWQA 5I12A 1QIAA 4HMAA 1AYKA 1UMTA 1FLSA 1SATA 1OMJA 3KMEA 1XFZA 3HDBA 456CA 3ZVSA 1FM1A 1K7QA 3LJZA 3DL1A 1XFUA 1KUHA 1BM6A 1OM8A
chains in the Genus database with same CATH superfamily
1YQYA 4JP4A 1R55A 2W15A 1QJJA 3LILA 4AYKA 5BPAA 3P1VA 4H49A 1C8TA 3ZUKA 3DTIA 4A3WA 2HU6A 1EB6A 3HBUP 2MZEA 2OY4A 1CQRA 1Y8JA 1GKCA 4HX3A 3LUNA 1ZXCA 2ERPA 2FV5A 2X3BA 1I1IP 3N2UA 3ZXHA 5I3MA 1KBCA 2TCLA 1HFSA 3RTSA 3V96B 1CIZA 2OW9A 2DDFA 1GO8P 4PKRA 1ASTA 3AYUA 2OXZA 830CA 2Z2DA 3HDAP 1SU3A 3LEAA 4GR3A 1BUDA 3I7GA 1B3DA 3TSKA 2D1OA 4G9LA 2FV9A 4H3XA 1JANA 1SLNA 2DW0A 1EAKA 3NX7A 5D2BA 4A7BA 2W13A 3OHOA 1D5JA 2YIGA 4AXQA 1OS9A 1XM5A 1Y0VA 2I47A 4IUWA 3DPFA 1OM6A 3VI1A 4AUOA 3LGPA 3LQ0A 2WO8A 2L0RA 5BOYA 1I76A 5H8XA 3EHXA 1K7IA 3B2ZA 5I2ZA 2OW1A 1QUAA 4XM7A 2D1NA 1A86A 3DPEA 1IADA 1JIZA 4JQGA 4FXYP 4L19A 2J0TA 4FU4A 2YB9A 3HBVP 4I03A 2YUFA 2ERQA 2Y6CA 1BZSA 3F15A 1BIWA 3B92A 1HTDA 2X7MA 4WK7A 1TVIA 1GE6A 4WKIA 1R1HA 2DW2A 1JIWP 4XM6A 1SLMA 1G05A 1SRPA 2RJPA 3EDZA 3RTTA 3UVCA 3KWVC 1KUGA 3OHLA 4PKWA 2J83A 1ZXVA 1KAPP 5L7FA 2X3CA 4XBHA 1QIBA 2WO9A 4DPEA 2N8RA 1BKCE 1RMZA 1YOUA 4FXQA 3K7LA 3TS4A 1GO7P 1ROSA 4L63A 1BUVM 1DMTA 4DD8A 3LJGA 3DSLA 5JMYA 2OVZA 1O0TA 1S4BP 1O0QA 1L6JA 4XM8A 4G0DA 1ATLA 1YP1A 2OY2A 3L0TA 3GBOA 1JKYA 5CZMA 3HB2P 1G9KA 5CXAA 1HOVA 2Y6DA 3VTGA 1UEAA 1G49A 3LUMA 1SMPA 2K2GA 4QKZA 1D8MA 5L79A 5I43A 4WKEA 1CXVA 4CTHA 4JA1A 2USNA 3KEKA 1PWWA 1AKLA 1BQQM 1KUIA 1KUFA 4WF6A 2XS4A 2O36A 2K9CA 3CKIA 2MLSA 3BA0A 3DTKA 3F16A 2OVXA 1CGFA 2POJA 5D1SA 2W12A 4GWNA 1MMPA 1JH1A 1RM8A 2O3EA 1CAQA 1C3IA 3HY7A 2W0DA 3AIGA 4DF9A 2V4BA 1UTZA 1A85A 2MZHA 3WV1A 1AF0A 1OS2A 3P24A 1IACA 3O2XA 1XURA 1D8FA 3WV2A 1MNCA 1JK3A 3HYGA 3DNGA 1R1JA 1DTHA 1ZVXA 2CLTA 2CKIA 5B5OA 2DDYA 1ZTQA 4L7AA 1K7GA 1XUDA 3WV3A 1XFVA 1UMSA 1XFYA 3LJTA 2OZRA 1OO9A 1OZ9A 1Q3AA 3KRYA 1CGEA 1MMBA 4H30A 4ZR5A 1HV5A 4IN9A 1IABA 3G5CA 2OXWA 3F18A 1PWVA 4GF1A 3LMCA 5B5PA 1J7NA 1BKCA 1BSWA 3LKAA 3KEJA 4H1QA 1IAAA 1GKDA 3LIKA 1OM7A 4XCTA 2JSDA 1HFCA 4H2EA 4Q1LA 3Q2GA 4PKSA 3L0VA 5D3CA 3DTEA 2JNPA 1MMQA 5D1UA 2QPJA 1B8YA 4EFSA 5D7WA 4I35A 1G4KA 3I7IA 4PKUA 2XS3A 5I4OA 3KHIA 4PKQA 1GE7A 3K7NA 4ILWD 1XAXA 3LK8A 1PWUA 1BKCI 3HY9A 5BOTA 1KUKA 1ZS0A 2OI0A 1QICA 1JJ9A 4R3VA 3MA2A 1IAGA 1JAOA 3USNA 3E8RA 3ELMA 1XUCA 4H82A 4L6TA 1XFWA 4PKTA 2PJTA 3F17A 3EDHA 3LQBA 1R54A 4J4MA 1PWPA 3U1RA 1YCMA 3LIRA 1JAPA 2AIGP 1XFXA 2OXUA 4JPAA 2RJQA 5I0LA 1JAQA 4WZVA 3DWBA 3F1AA 5CUHA 4DV8A 966CA 2E3XA 5D1TA 4FVLA 2OW0A 2JT5A 1ZP5A 3B8ZA 4IJOA 3G42A 4GR8A 3AYKA 1H71P 2WOAA 3KECA 4AIGA 4H84A 2DW1A 1GE5A 3EDGA 3EDIA 2EROA 4JIJA 2E2DA 3EHYA 1ND1A 4GUYA 4GWMA 3SHIA 4H76A 2AYKA 1Z3JA 1HY7A 1IAEA 3Q2HA 1GXDA 3EWJA 1G12A 1QJIA 1I73A 3N2VA 4GR0A 4ON1A 2JT6A 3TVCA 3KMCA 1CK7A 3LE9A 2OW2A 1R1IA 2W14A 1WNIA 2SRTA 1Y93A 3F19A 2KRJA 1EUBA 2MZIA 1UTTA 1MMRA 2JIHA 1FBLA 5LABA 3TT4A 2X3AA 3O64A 2MLRA 4GQLA 1CGLA 1USNA 2A8HA 1C7KA 4PKVA 1BQOA 1D7XA 1PWQA 5I12A 1QIAA 4HMAA 1AYKA 1UMTA 1FLSA 1SATA 1OMJA 3KMEA 1XFZA 3HDBA 456CA 3ZVSA 1FM1A 1K7QA 3LJZA 3DL1A 1XFUA 1KUHA 1BM6A 1OM8A
chains in the Genus database with same CATH topology
1YQYA 4JP4A 1R55A 2W15A 1QJJA 3LILA 4AYKA 5BPAA 3P1VA 4H49A 1C8TA 3ZUKA 3DTIA 4A3WA 2HU6A 1EB6A 3HBUP 2MZEA 2OY4A 1CQRA 1Y8JA 1GKCA 4HX3A 3LUNA 1ZXCA 2ERPA 2FV5A 2X3BA 1I1IP 3N2UA 3ZXHA 5I3MA 1KBCA 2TCLA 1HFSA 3RTSA 3V96B 1CIZA 2OW9A 2DDFA 1GO8P 4PKRA 1ASTA 3AYUA 2OXZA 830CA 2Z2DA 3HDAP 1SU3A 3LEAA 4GR3A 1BUDA 3I7GA 1B3DA 3TSKA 2D1OA 4G9LA 2FV9A 4H3XA 1JANA 1SLNA 2DW0A 1EAKA 3NX7A 5D2BA 4A7BA 2W13A 3OHOA 1D5JA 2YIGA 4AXQA 1OS9A 1Y0VA 2I47A 4IUWA 3DPFA 1OM6A 3VI1A 4AUOA 3LGPA 3LQ0A 2WO8A 2L0RA 5BOYA 1I76A 5H8XA 3EHXA 1K7IA 3B2ZA 5I2ZA 2OW1A 1QUAA 4XM7A 2D1NA 1A86A 3DPEA 1IADA 1JIZA 4JQGA 4FXYP 4L19A 2J0TA 4FU4A 2YB9A 3HBVP 4I03A 2YUFA 2ERQA 2Y6CA 1BZSA 3F15A 1BIWA 3B92A 1HTDA 2X7MA 4WK7A 1GE6A 4WKIA 1R1HA 2DW2A 1JIWP 4XM6A 1SLMA 1G05A 1SRPA 2RJPA 3EDZA 3RTTA 3UVCA 3KWVC 1KUGA 3OHLA 4PKWA 2J83A 1ZXVA 1KAPP 5L7FA 2X3CA 4XBHA 1QIBA 2WO9A 4DPEA 2N8RA 1BKCE 1RMZA 1YOUA 4FXQA 3K7LA 3TS4A 1GO7P 1ROSA 4L63A 1BUVM 1DMTA 4DD8A 3LJGA 3DSLA 5JMYA 2OVZA 1O0TA 1S4BP 1O0QA 1L6JA 4XM8A 4G0DA 1ATLA 1YP1A 2OY2A 3L0TA 3GBOA 1JKYA 5CZMA 3HB2P 1G9KA 5CXAA 1HOVA 2Y6DA 3VTGA 1UEAA 1G49A 3LUMA 1SMPA 2K2GA 4QKZA 1D8MA 5L79A 5I43A 4WKEA 1CXVA 4CTHA 4JA1A 2USNA 3KEKA 1PWWA 1AKLA 1BQQM 1KUIA 1KUFA 4WF6A 2XS4A 2O36A 2K9CA 3CKIA 2MLSA 3BA0A 3DTKA 3F16A 2OVXA 1CGFA 2POJA 5D1SA 2W12A 4GWNA 1MMPA 1JH1A 1RM8A 2O3EA 1CAQA 1C3IA 3HY7A 2W0DA 3AIGA 4DF9A 2V4BA 1UTZA 1A85A 2MZHA 3WV1A 1AF0A 1OS2A 3P24A 1IACA 3O2XA 1XURA 1D8FA 3WV2A 1MNCA 1JK3A 3HYGA 3DNGA 1R1JA 1DTHA 1ZVXA 2CLTA 2CKIA 5B5OA 2DDYA 1ZTQA 4L7AA 1K7GA 1XUDA 3WV3A 1XFVA 1UMSA 1XFYA 3LJTA 2OZRA 1OO9A 1Q3AA 3KRYA 1CGEA 1MMBA 4H30A 4ZR5A 1HV5A 4IN9A 1IABA 3G5CA 2OXWA 3F18A 1PWVA 4GF1A 3LMCA 5B5PA 1J7NA 1BKCA 1BSWA 3LKAA 3KEJA 4H1QA 1IAAA 1GKDA 3LIKA 1OM7A 4XCTA 2JSDA 1HFCA 4H2EA 4Q1LA 3Q2GA 4PKSA 3L0VA 5D3CA 3DTEA 2JNPA 1MMQA 5D1UA 2QPJA 1B8YA 4EFSA 5D7WA 4I35A 1G4KA 3I7IA 4PKUA 2XS3A 5I4OA 3KHIA 4PKQA 1GE7A 3K7NA 4ILWD 3LK8A 1PWUA 1BKCI 3HY9A 5BOTA 1KUKA 1ZS0A 2OI0A 1QICA 1JJ9A 4R3VA 3MA2A 1IAGA 1JAOA 3USNA 3E8RA 3ELMA 1XUCA 4H82A 4L6TA 1XFWA 4PKTA 2PJTA 3F17A 3EDHA 3LQBA 1R54A 4J4MA 1PWPA 3U1RA 1YCMA 3LIRA 1JAPA 2AIGP 1XFXA 2OXUA 4JPAA 2RJQA 5I0LA 1JAQA 4WZVA 3DWBA 3F1AA 5CUHA 4DV8A 966CA 2E3XA 5D1TA 4FVLA 2OW0A 2JT5A 1ZP5A 3B8ZA 4IJOA 3G42A 4GR8A 3AYKA 1H71P 2WOAA 3KECA 4AIGA 4H84A 2DW1A 1GE5A 3EDGA 3EDIA 2EROA 4JIJA 2E2DA 3EHYA 1ND1A 4GUYA 4GWMA 3SHIA 4H76A 2AYKA 1Z3JA 1HY7A 1IAEA 3Q2HA 1GXDA 3EWJA 1G12A 1QJIA 1I73A 3N2VA 4GR0A 4ON1A 2JT6A 3TVCA 3KMCA 1CK7A 3LE9A 2OW2A 1R1IA 2W14A 1WNIA 2SRTA 1Y93A 3F19A 2KRJA 1EUBA 2MZIA 1UTTA 1MMRA 2JIHA 1FBLA 5LABA 3TT4A 2X3AA 3O64A 2MLRA 4GQLA 1CGLA 1USNA 2A8HA 1C7KA 4PKVA 1BQOA 1D7XA 1PWQA 5I12A 1QIAA 4HMAA 1AYKA 1UMTA 1FLSA 1SATA 1OMJA 3KMEA 1XFZA 3HDBA 456CA 3ZVSA 1FM1A 1K7QA 3LJZA 3DL1A 1XFUA 1KUHA 1BM6A 1OM8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YQY A;  4JP4 A;  1R55 A;  2W15 A;  1QJJ A;  3LIL A;  4AYK A;  5BPA A;  3P1V A;  4H49 A;  1C8T A;  3ZUK A;  4A3W A;  2HU6 A;  1EB6 A;  3HBU P;  2MZE A;  2OY4 A;  1CQR A;  1Y8J A;  1GKC A;  4HX3 A;  3LUN A;  1ZXC A;  2ERP A;  2FV5 A;  2X3B A;  1I1I P;  3N2U A;  3ZXH A;  5I3M A;  1KBC A;  2TCL A;  1HFS A;  3RTS A;  3V96 B;  1CIZ A;  2OW9 A;  2DDF A;  1GO8 P;  4PKR A;  1AST A;  3AYU A;  2OXZ A;  830C A;  2Z2D A;  3HDA P;  1SU3 A;  3LEA A;  4GR3 A;  1BUD A;  3I7G A;  1B3D A;  3TSK A;  2D1O A;  4G9L A;  2FV9 A;  4H3X A;  1JAN A;  1SLN A;  2DW0 A;  1EAK A;  3NX7 A;  5D2B A;  4A7B A;  2W13 A;  3OHO A;  1D5J A;  2YIG A;  4AXQ A;  1OS9 A;  1Y0V A;  2I47 A;  4IUW A;  3DPF A;  1OM6 A;  3VI1 A;  4AUO A;  3LGP A;  3LQ0 A;  2WO8 A;  2L0R A;  5BOY A;  1I76 A;  5H8X A;  3EHX A;  1K7I A;  3B2Z A;  5I2Z A;  2OW1 A;  1QUA A;  4XM7 A;  2D1N A;  1A86 A;  3DPE A;  1IAD A;  1JIZ A;  4JQG A;  4FXY P;  4L19 A;  2J0T A;  4FU4 A;  2YB9 A;  3HBV P;  4I03 A;  2ERQ A;  2Y6C A;  1BZS A;  3F15 A;  1BIW A;  3B92 A;  1HTD A;  2X7M A;  4WK7 A;  1GE6 A;  4WKI A;  1R1H A;  2DW2 A;  1JIW P;  4XM6 A;  1SLM A;  1G05 A;  1SRP A;  2RJP A;  3EDZ A;  3RTT A;  3UVC A;  3KWV C;  1KUG A;  3OHL A;  4PKW A;  2J83 A;  1ZXV A;  1KAP P;  5L7F A;  2X3C A;  4XBH A;  1QIB A;  2WO9 A;  4DPE A;  2N8R A;  1BKC E;  1RMZ A;  1YOU A;  4FXQ A;  3K7L A;  3TS4 A;  1GO7 P;  1ROS A;  4L63 A;  1BUV M;  1DMT A;  4DD8 A;  3LJG A;  3DSL A;  5JMY A;  2OVZ A;  1O0T A;  1S4B P;  1O0Q A;  1L6J A;  4XM8 A;  4G0D A;  1ATL A;  1YP1 A;  2OY2 A;  3L0T A;  3GBO A;  1JKY A;  5CZM A;  3HB2 P;  1G9K A;  5CXA A;  1HOV A;  2Y6D A;  3VTG A;  1UEA A;  1G49 A;  3LUM A;  1SMP A;  2K2G A;  4QKZ A;  1D8M A;  5L79 A;  5I43 A;  4WKE A;  1CXV A;  4CTH A;  4JA1 A;  2USN A;  3KEK A;  1PWW A;  1AKL A;  1BQQ M;  1KUI A;  1KUF A;  4WF6 A;  2XS4 A;  2O36 A;  2K9C A;  3CKI A;  2MLS A;  3BA0 A;  3F16 A;  2OVX A;  1CGF A;  2POJ A;  5D1S A;  2W12 A;  4GWN A;  1MMP A;  1JH1 A;  1RM8 A;  2O3E A;  1CAQ A;  1C3I A;  3HY7 A;  2W0D A;  3AIG A;  4DF9 A;  2V4B A;  1UTZ A;  1A85 A;  2MZH A;  3WV1 A;  1AF0 A;  1OS2 A;  3P24 A;  1IAC A;  3O2X A;  1XUR A;  1D8F A;  3WV2 A;  1MNC A;  1JK3 A;  3HYG A;  3DNG A;  1R1J A;  1DTH A;  1ZVX A;  2CLT A;  2CKI A;  5B5O A;  2DDY A;  1ZTQ A;  1K7G A;  1XUD A;  3WV3 A;  1XFV A;  1UMS A;  1XFY A;  3LJT A;  2OZR A;  1OO9 A;  1Q3A A;  3KRY A;  1CGE A;  1MMB A;  4H30 A;  4ZR5 A;  1HV5 A;  4IN9 A;  1IAB A;  3G5C A;  2OXW A;  3F18 A;  1PWV A;  4GF1 A;  3LMC A;  5B5P A;  1J7N A;  1BKC A;  1BSW A;  3LKA A;  3KEJ A;  4H1Q A;  1IAA A;  1GKD A;  3LIK A;  1OM7 A;  4XCT A;  2JSD A;  1HFC A;  4H2E A;  4Q1L A;  3Q2G A;  4PKS A;  3L0V A;  5D3C A;  2JNP A;  1MMQ A;  5D1U A;  2QPJ A;  1B8Y A;  4EFS A;  5D7W A;  4I35 A;  1G4K A;  3I7I A;  4PKU A;  2XS3 A;  5I4O A;  3KHI A;  4PKQ A;  1GE7 A;  3K7N A;  4ILW D;  3LK8 A;  1PWU A;  1BKC I;  3HY9 A;  5BOT A;  1KUK A;  1ZS0 A;  2OI0 A;  1QIC A;  1JJ9 A;  4R3V A;  3MA2 A;  1IAG A;  1JAO A;  3USN A;  3E8R A;  3ELM A;  1XUC A;  4H82 A;  4L6T A;  1XFW A;  4PKT A;  2PJT A;  3F17 A;  3EDH A;  3LQB A;  1R54 A;  4J4M A;  1PWP A;  3U1R A;  1YCM A;  3LIR A;  1JAP A;  2AIG P;  1XFX A;  2OXU A;  4JPA A;  2RJQ A;  5I0L A;  1JAQ A;  4WZV A;  3DWB A;  3F1A A;  5CUH A;  4DV8 A;  966C A;  2E3X A;  5D1T A;  4FVL A;  2OW0 A;  2JT5 A;  1ZP5 A;  3B8Z A;  4IJO A;  3G42 A;  4GR8 A;  3AYK A;  1H71 P;  2WOA A;  3KEC A;  4AIG A;  4H84 A;  2DW1 A;  1GE5 A;  3EDG A;  3EDI A;  2ERO A;  4JIJ A;  2E2D A;  3EHY A;  1ND1 A;  4GUY A;  4GWM A;  3SHI A;  4H76 A;  2AYK A;  1Z3J A;  1HY7 A;  1IAE A;  3Q2H A;  1GXD A;  3EWJ A;  1G12 A;  1QJI A;  1I73 A;  3N2V A;  4GR0 A;  4ON1 A;  2JT6 A;  3TVC A;  3KMC A;  1CK7 A;  3LE9 A;  2OW2 A;  1R1I A;  2W14 A;  1WNI A;  2SRT A;  1Y93 A;  3F19 A;  2KRJ A;  1EUB A;  2MZI A;  1UTT A;  1MMR A;  2JIH A;  1FBL A;  5LAB A;  3TT4 A;  2X3A A;  3O64 A;  2MLR A;  4GQL A;  1CGL A;  1USN A;  2A8H A;  1C7K A;  4PKV A;  1BQO A;  1D7X A;  1PWQ A;  5I12 A;  1QIA A;  4HMA A;  1AYK A;  1UMT A;  1FLS A;  1SAT A;  1OMJ A;  3KME A;  1XFZ A;  3HDB A;  456C A;  3ZVS A;  1FM1 A;  1K7Q A;  3LJZ A;  3DL1 A;  1XFU A;  1KUH A;  1BM6 A;  1OM8 A; 
#chains in the Genus database with same CATH topology
 1YQY A;  4JP4 A;  1R55 A;  2W15 A;  1QJJ A;  3LIL A;  4AYK A;  5BPA A;  3P1V A;  4H49 A;  1C8T A;  3ZUK A;  3DTI A;  4A3W A;  2HU6 A;  1EB6 A;  3HBU P;  2MZE A;  2OY4 A;  1CQR A;  1Y8J A;  1GKC A;  4HX3 A;  3LUN A;  1ZXC A;  2ERP A;  2FV5 A;  2X3B A;  1I1I P;  3N2U A;  3ZXH A;  5I3M A;  1KBC A;  2TCL A;  1HFS A;  3RTS A;  3V96 B;  1CIZ A;  2OW9 A;  2DDF A;  1GO8 P;  4PKR A;  1AST A;  3AYU A;  2OXZ A;  830C A;  2Z2D A;  3HDA P;  1SU3 A;  3LEA A;  4GR3 A;  1BUD A;  3I7G A;  1B3D A;  3TSK A;  2D1O A;  4G9L A;  2FV9 A;  4H3X A;  1JAN A;  1SLN A;  2DW0 A;  1EAK A;  3NX7 A;  5D2B A;  4A7B A;  2W13 A;  3OHO A;  1D5J A;  2YIG A;  4AXQ A;  1OS9 A;  1XM5 A;  1Y0V A;  2I47 A;  4IUW A;  3DPF A;  1OM6 A;  3VI1 A;  4AUO A;  3LGP A;  3LQ0 A;  2WO8 A;  2L0R A;  5BOY A;  1I76 A;  5H8X A;  3EHX A;  1K7I A;  3B2Z A;  5I2Z A;  2OW1 A;  1QUA A;  4XM7 A;  2D1N A;  1A86 A;  3DPE A;  1IAD A;  1JIZ A;  4JQG A;  4FXY P;  4L19 A;  2J0T A;  4FU4 A;  2YB9 A;  3HBV P;  4I03 A;  2YUF A;  2ERQ A;  2Y6C A;  1BZS A;  3F15 A;  1BIW A;  3B92 A;  1HTD A;  2X7M A;  4WK7 A;  1TVI A;  1GE6 A;  4WKI A;  1R1H A;  2DW2 A;  1JIW P;  4XM6 A;  1SLM A;  1G05 A;  1SRP A;  2RJP A;  3EDZ A;  3RTT A;  3UVC A;  3KWV C;  1KUG A;  3OHL A;  4PKW A;  2J83 A;  1ZXV A;  1KAP P;  5L7F A;  2X3C A;  4XBH A;  1QIB A;  2WO9 A;  4DPE A;  2N8R A;  1BKC E;  1RMZ A;  1YOU A;  4FXQ A;  3K7L A;  3TS4 A;  1GO7 P;  1ROS A;  4L63 A;  1BUV M;  1DMT A;  4DD8 A;  3LJG A;  3DSL A;  5JMY A;  2OVZ A;  1O0T A;  1S4B P;  1O0Q A;  1L6J A;  4XM8 A;  4G0D A;  1ATL A;  1YP1 A;  2OY2 A;  3L0T A;  3GBO A;  1JKY A;  5CZM A;  3HB2 P;  1G9K A;  5CXA A;  1HOV A;  2Y6D A;  3VTG A;  1UEA A;  1G49 A;  3LUM A;  1SMP A;  2K2G A;  4QKZ A;  1D8M A;  5L79 A;  5I43 A;  4WKE A;  1CXV A;  4CTH A;  4JA1 A;  2USN A;  3KEK A;  1PWW A;  1AKL A;  1BQQ M;  1KUI A;  1KUF A;  4WF6 A;  2XS4 A;  2O36 A;  2K9C A;  3CKI A;  2MLS A;  3BA0 A;  3DTK A;  3F16 A;  2OVX A;  1CGF A;  2POJ A;  5D1S A;  2W12 A;  4GWN A;  1MMP A;  1JH1 A;  1RM8 A;  2O3E A;  1CAQ A;  1C3I A;  3HY7 A;  2W0D A;  3AIG A;  4DF9 A;  2V4B A;  1UTZ A;  1A85 A;  2MZH A;  3WV1 A;  1AF0 A;  1OS2 A;  3P24 A;  1IAC A;  3O2X A;  1XUR A;  1D8F A;  3WV2 A;  1MNC A;  1JK3 A;  3HYG A;  3DNG A;  1R1J A;  1DTH A;  1ZVX A;  2CLT A;  2CKI A;  5B5O A;  2DDY A;  1ZTQ A;  4L7A A;  1K7G A;  1XUD A;  3WV3 A;  1XFV A;  1UMS A;  1XFY A;  3LJT A;  2OZR A;  1OO9 A;  1OZ9 A;  1Q3A A;  3KRY A;  1CGE A;  1MMB A;  4H30 A;  4ZR5 A;  1HV5 A;  4IN9 A;  1IAB A;  3G5C A;  2OXW A;  3F18 A;  1PWV A;  4GF1 A;  3LMC A;  5B5P A;  1J7N A;  1BKC A;  1BSW A;  3LKA A;  3KEJ A;  4H1Q A;  1IAA A;  1GKD A;  3LIK A;  1OM7 A;  4XCT A;  2JSD A;  1HFC A;  4H2E A;  4Q1L A;  3Q2G A;  4PKS A;  3L0V A;  5D3C A;  3DTE A;  2JNP A;  1MMQ A;  5D1U A;  2QPJ A;  1B8Y A;  4EFS A;  5D7W A;  4I35 A;  1G4K A;  3I7I A;  4PKU A;  2XS3 A;  5I4O A;  3KHI A;  4PKQ A;  1GE7 A;  3K7N A;  4ILW D;  1XAX A;  3LK8 A;  1PWU A;  1BKC I;  3HY9 A;  5BOT A;  1KUK A;  1ZS0 A;  2OI0 A;  1QIC A;  1JJ9 A;  4R3V A;  3MA2 A;  1IAG A;  1JAO A;  3USN A;  3E8R A;  3ELM A;  1XUC A;  4H82 A;  4L6T A;  1XFW A;  4PKT A;  2PJT A;  3F17 A;  3EDH A;  3LQB A;  1R54 A;  4J4M A;  1PWP A;  3U1R A;  1YCM A;  3LIR A;  1JAP A;  2AIG P;  1XFX A;  2OXU A;  4JPA A;  2RJQ A;  5I0L A;  1JAQ A;  4WZV A;  3DWB A;  3F1A A;  5CUH A;  4DV8 A;  966C A;  2E3X A;  5D1T A;  4FVL A;  2OW0 A;  2JT5 A;  1ZP5 A;  3B8Z A;  4IJO A;  3G42 A;  4GR8 A;  3AYK A;  1H71 P;  2WOA A;  3KEC A;  4AIG A;  4H84 A;  2DW1 A;  1GE5 A;  3EDG A;  3EDI A;  2ERO A;  4JIJ A;  2E2D A;  3EHY A;  1ND1 A;  4GUY A;  4GWM A;  3SHI A;  4H76 A;  2AYK A;  1Z3J A;  1HY7 A;  1IAE A;  3Q2H A;  1GXD A;  3EWJ A;  1G12 A;  1QJI A;  1I73 A;  3N2V A;  4GR0 A;  4ON1 A;  2JT6 A;  3TVC A;  3KMC A;  1CK7 A;  3LE9 A;  2OW2 A;  1R1I A;  2W14 A;  1WNI A;  2SRT A;  1Y93 A;  3F19 A;  2KRJ A;  1EUB A;  2MZI A;  1UTT A;  1MMR A;  2JIH A;  1FBL A;  5LAB A;  3TT4 A;  2X3A A;  3O64 A;  2MLR A;  4GQL A;  1CGL A;  1USN A;  2A8H A;  1C7K A;  4PKV A;  1BQO A;  1D7X A;  1PWQ A;  5I12 A;  1QIA A;  4HMA A;  1AYK A;  1UMT A;  1FLS A;  1SAT A;  1OMJ A;  3KME A;  1XFZ A;  3HDB A;  456C A;  3ZVS A;  1FM1 A;  1K7Q A;  3LJZ A;  3DL1 A;  1XFU A;  1KUH A;  1BM6 A;  1OM8 A; 
#chains in the Genus database with same CATH homology
 1YQY A;  4JP4 A;  1R55 A;  2W15 A;  1QJJ A;  3LIL A;  4AYK A;  5BPA A;  3P1V A;  4H49 A;  1C8T A;  3ZUK A;  3DTI A;  4A3W A;  2HU6 A;  1EB6 A;  3HBU P;  2MZE A;  2OY4 A;  1CQR A;  1Y8J A;  1GKC A;  4HX3 A;  3LUN A;  1ZXC A;  2ERP A;  2FV5 A;  2X3B A;  1I1I P;  3N2U A;  3ZXH A;  5I3M A;  1KBC A;  2TCL A;  1HFS A;  3RTS A;  3V96 B;  1CIZ A;  2OW9 A;  2DDF A;  1GO8 P;  4PKR A;  1AST A;  3AYU A;  2OXZ A;  830C A;  2Z2D A;  3HDA P;  1SU3 A;  3LEA A;  4GR3 A;  1BUD A;  3I7G A;  1B3D A;  3TSK A;  2D1O A;  4G9L A;  2FV9 A;  4H3X A;  1JAN A;  1SLN A;  2DW0 A;  1EAK A;  3NX7 A;  5D2B A;  4A7B A;  2W13 A;  3OHO A;  1D5J A;  2YIG A;  4AXQ A;  1OS9 A;  1Y0V A;  2I47 A;  4IUW A;  3DPF A;  1OM6 A;  3VI1 A;  4AUO A;  3LGP A;  3LQ0 A;  2WO8 A;  2L0R A;  5BOY A;  1I76 A;  5H8X A;  3EHX A;  1K7I A;  3B2Z A;  5I2Z A;  2OW1 A;  1QUA A;  4XM7 A;  2D1N A;  1A86 A;  3DPE A;  1IAD A;  1JIZ A;  4JQG A;  4FXY P;  4L19 A;  2J0T A;  4FU4 A;  2YB9 A;  3HBV P;  4I03 A;  2YUF A;  2ERQ A;  2Y6C A;  1BZS A;  3F15 A;  1BIW A;  3B92 A;  1HTD A;  2X7M A;  4WK7 A;  1GE6 A;  4WKI A;  1R1H A;  2DW2 A;  1JIW P;  4XM6 A;  1SLM A;  1G05 A;  1SRP A;  2RJP A;  3EDZ A;  3RTT A;  3UVC A;  3KWV C;  1KUG A;  3OHL A;  4PKW A;  2J83 A;  1ZXV A;  1KAP P;  5L7F A;  2X3C A;  4XBH A;  1QIB A;  2WO9 A;  4DPE A;  2N8R A;  1BKC E;  1RMZ A;  1YOU A;  4FXQ A;  3K7L A;  3TS4 A;  1GO7 P;  1ROS A;  4L63 A;  1BUV M;  1DMT A;  4DD8 A;  3LJG A;  3DSL A;  5JMY A;  2OVZ A;  1O0T A;  1S4B P;  1O0Q A;  1L6J A;  4XM8 A;  4G0D A;  1ATL A;  1YP1 A;  2OY2 A;  3L0T A;  3GBO A;  1JKY A;  5CZM A;  3HB2 P;  1G9K A;  5CXA A;  1HOV A;  2Y6D A;  3VTG A;  1UEA A;  1G49 A;  3LUM A;  1SMP A;  2K2G A;  4QKZ A;  1D8M A;  5L79 A;  5I43 A;  4WKE A;  1CXV A;  4CTH A;  4JA1 A;  2USN A;  3KEK A;  1PWW A;  1AKL A;  1BQQ M;  1KUI A;  1KUF A;  4WF6 A;  2XS4 A;  2O36 A;  2K9C A;  3CKI A;  2MLS A;  3BA0 A;  3DTK A;  3F16 A;  2OVX A;  1CGF A;  2POJ A;  5D1S A;  2W12 A;  4GWN A;  1MMP A;  1JH1 A;  1RM8 A;  2O3E A;  1CAQ A;  1C3I A;  3HY7 A;  2W0D A;  3AIG A;  4DF9 A;  2V4B A;  1UTZ A;  1A85 A;  2MZH A;  3WV1 A;  1AF0 A;  1OS2 A;  3P24 A;  1IAC A;  3O2X A;  1XUR A;  1D8F A;  3WV2 A;  1MNC A;  1JK3 A;  3HYG A;  3DNG A;  1R1J A;  1DTH A;  1ZVX A;  2CLT A;  2CKI A;  5B5O A;  2DDY A;  1ZTQ A;  4L7A A;  1K7G A;  1XUD A;  3WV3 A;  1XFV A;  1UMS A;  1XFY A;  3LJT A;  2OZR A;  1OO9 A;  1Q3A A;  3KRY A;  1CGE A;  1MMB A;  4H30 A;  4ZR5 A;  1HV5 A;  4IN9 A;  1IAB A;  3G5C A;  2OXW A;  3F18 A;  1PWV A;  4GF1 A;  3LMC A;  5B5P A;  1J7N A;  1BKC A;  1BSW A;  3LKA A;  3KEJ A;  4H1Q A;  1IAA A;  1GKD A;  3LIK A;  1OM7 A;  4XCT A;  2JSD A;  1HFC A;  4H2E A;  4Q1L A;  3Q2G A;  4PKS A;  3L0V A;  5D3C A;  3DTE A;  2JNP A;  1MMQ A;  5D1U A;  2QPJ A;  1B8Y A;  4EFS A;  5D7W A;  4I35 A;  1G4K A;  3I7I A;  4PKU A;  2XS3 A;  5I4O A;  3KHI A;  4PKQ A;  1GE7 A;  3K7N A;  4ILW D;  3LK8 A;  1PWU A;  1BKC I;  3HY9 A;  5BOT A;  1KUK A;  1ZS0 A;  2OI0 A;  1QIC A;  1JJ9 A;  4R3V A;  3MA2 A;  1IAG A;  1JAO A;  3USN A;  3E8R A;  3ELM A;  1XUC A;  4H82 A;  4L6T A;  1XFW A;  4PKT A;  2PJT A;  3F17 A;  3EDH A;  3LQB A;  1R54 A;  4J4M A;  1PWP A;  3U1R A;  1YCM A;  3LIR A;  1JAP A;  2AIG P;  1XFX A;  2OXU A;  4JPA A;  2RJQ A;  5I0L A;  1JAQ A;  4WZV A;  3DWB A;  3F1A A;  5CUH A;  4DV8 A;  966C A;  2E3X A;  5D1T A;  4FVL A;  2OW0 A;  2JT5 A;  1ZP5 A;  3B8Z A;  4IJO A;  3G42 A;  4GR8 A;  3AYK A;  1H71 P;  2WOA A;  3KEC A;  4AIG A;  4H84 A;  2DW1 A;  1GE5 A;  3EDG A;  3EDI A;  2ERO A;  4JIJ A;  2E2D A;  3EHY A;  1ND1 A;  4GUY A;  4GWM A;  3SHI A;  4H76 A;  2AYK A;  1Z3J A;  1HY7 A;  1IAE A;  3Q2H A;  1GXD A;  3EWJ A;  1G12 A;  1QJI A;  1I73 A;  3N2V A;  4GR0 A;  4ON1 A;  2JT6 A;  3TVC A;  3KMC A;  1CK7 A;  3LE9 A;  2OW2 A;  1R1I A;  2W14 A;  1WNI A;  2SRT A;  1Y93 A;  3F19 A;  2KRJ A;  1EUB A;  2MZI A;  1UTT A;  1MMR A;  2JIH A;  1FBL A;  5LAB A;  3TT4 A;  2X3A A;  3O64 A;  2MLR A;  4GQL A;  1CGL A;  1USN A;  2A8H A;  1C7K A;  4PKV A;  1BQO A;  1D7X A;  1PWQ A;  5I12 A;  1QIA A;  4HMA A;  1AYK A;  1UMT A;  1FLS A;  1SAT A;  1OMJ A;  3KME A;  1XFZ A;  3HDB A;  456C A;  3ZVS A;  1FM1 A;  1K7Q A;  3LJZ A;  3DL1 A;  1XFU A;  1KUH A;  1BM6 A;  1OM8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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