2OI0A

Crystal structure analysis 0f the tnf-a coverting enzyme (tace) in complexed with aryl-sulfonamide
Total Genus 89
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
89
sequence length
266
structure length
266
Chain Sequence
ADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERSNKVIEGR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Homo sapiens
publication title Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides
pubmed doi rcsb
molecule keywords TNF- a Converting Enzyme (TACE)
total genus 89
structure length 266
sequence length 266
ec nomenclature ec 3.4.24.86: ADAM 17 endopeptidase.
pdb deposition date 2007-01-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13688 Reprolysin_5 Metallo-peptidase family M12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 2oi0A00
1Q3AA 3ZXHA 1XFXA 1YOUA 2OY4A 1G05A 1FBLA 3HB2P 1Z3JA 4I03A 3RTSA 3B8ZA 2E2DA 3F1AA 4GR8A 2DW2A 3SHIA 1HOVA 2OW9A 1BIWA 2OW2A 2JNPA 4J4MA 1S4BP 2AYKA 1OS2A 4H30A 1KUKA 2YIGA 1CAQA 4WF6A 4AUOA 1JAOA 1SLNA 3EDZA 3LQBA 1BKCI 4G9LA 4L63A 5L79A 2K2GA 3DSLA 5LABA 1OM8A 3I7GA 2JT5A 2DW0A 4H84A 2HU6A 2QPJA 3P1VA 3P24A 4EFSA 1QIBA 3TVCA 3LK8A 1I76A 5D2BA 3TSKA 4I35A 1JKYA 4L19A 4XCTA 5I3MA 1AKLA 3RTTA 4DPEA 1CQRA 1MNCA 1JAQA 3Q2HA 1Y8JA 2K9CA 2OXUA 1O0TA 1H71P 2X3CA 3B2ZA 1I73A 1D5JA 1Y93A 3LJTA 1CGFA 2POJA 4GF1A 4JQGA 3WV2A 3USNA 1B3DA 2V4BA 2YB9A 1EB6A 3WV1A 1CK7A 1JH1A 1RM8A 3EDGA 1OM6A 1MMRA 4PKRA 5D7WA 1AYKA 1CGLA 1KUFA 3DPFA 2JSDA 4GR3A 2A8HA 4ON1A 1CGEA 2Z2DA 2D1OA 1C7KA 2OVZA 2OW1A 4L6TA 1UMTA 1XFWA 3KECA 1HFSA 3EDHA 3EWJA 1GE7A 1XURA 3F19A 3KMCA 2OY2A 1DMTA 5CZMA 4FU4A 2JIHA 4JPAA 5CUHA 1BSWA 4PKSA 2MLRA 3F18A 1BUVM 1BUDA 1ATLA 1XFYA 3E8RA 3B92A 1SU3A 3LIRA 5I12A 2MZEA 1GXDA 1L6JA 2FV5A 1SLMA 5JMYA 1R54A 1D7XA 1YQYA 5BPAA 2CLTA 2RJQA 1R1JA 5B5OA 1YP1A 1JIZA 2EROA 1EAKA 1AF0A 1PWQA 4A7BA 3TS4A 3HBVP 1GKCA 1K7GA 3K7NA 1KBCA 3VI1A 1R55A 2MZHA 3LJGA 4XM7A 4WKEA 1GE6A 2OI0A 3LUNA 2W14A 1ZVXA 1C3IA 4GWMA 1G12A 2XS4A 1SRPA 5I2ZA 1MMQA 4IUWA 2W12A 1HV5A 4AIGA 5CXAA 4H76A 2TCLA 3BA0A 4PKUA 2SRTA 4H82A 5BOYA 1D8MA 2X3BA 1GKDA 2KRJA 4ZR5A 3KWVC 3U1RA 2OVXA 1QJIA 1PWPA 1Y0VA 3LEAA 4PKWA 4WZVA 2OXWA 2CKIA 1UTZA 3LUMA 3HBUP 1OO9A 2XS3A 5D1SA 3LMCA 2OZRA 5B5PA 2Y6CA 1JK3A 1KUIA 3ELMA 3TT4A 1WNIA 1BKCA 456CA 4IN9A 1YCMA 4DF9A 4DD8A 4GUYA 1RMZA 5BOTA 1ZXVA 3HYGA 4XM6A 3AIGA 2PJTA 3N2UA 4WK7A 4XBHA 4AYKA 1G4KA 3DL1A 1BQOA 3KHIA 1OM7A 1FM1A 4FXYP 3I7IA 1PWWA 1QUAA 1JAPA 1KAPP 4A3WA 4R3VA 1FLSA 1EUBA 4H1QA 4AXQA 1IAAA 2J0TA 1XFUA 2O36A 4HMAA 1HY7A 4PKTA 2W15A 3F16A 1A86A 3N2VA 1GO8P 4PKQA 4CTHA 3ZUKA 4IJOA 3LE9A 2ERPA 4QKZA 5I0LA 1ZXCA 3LKAA 5D3CA 2DDYA 1SMPA 3V96B 1IAEA 1BQQM 3LGPA 4H2EA 1MMPA 4HX3A 1PWUA 1XUCA 1J7NA 1A85A 4H3XA 3EDIA 2L0RA 2WO9A 4H49A 2DDFA 2W13A 1BM6A 1CXVA 4JA1A 2AIGP 1USNA 1SATA 1XFZA 4ILWD 5D1TA 1UEAA 3Q2GA 1XUDA 4GWNA 1DTHA 2Y6DA 4PKVA 1GE5A 1QJJA 3GBOA 3OHLA 2FV9A 2WOAA 3KMEA 1JANA 3O64A 4GQLA 1O0QA 5L7FA 1UMSA 1JIWP 1K7IA 1CIZA 2JT6A 2USNA 1ZTQA 1QICA 4G0DA 3LQ0A 3O2XA 3EHYA 5H8XA 2RJPA 2I47A 1R1IA 2X7MA 3L0VA 1B8YA 1ROSA 3DWBA 5I4OA 1K7QA 2X3AA 3EHXA 1G9KA 1R1HA 3F17A 1ND1A 1XFVA 1ASTA 4XM8A 2D1NA 1IADA 3K7LA 1IABA 3DNGA 3NX7A 3HY9A 3VTGA 1IACA 3OHOA 3HDAP 5D1UA 2WO8A 3HY7A 1OS9A 1PWVA 1ZS0A 3KRYA 1D8FA 1KUGA 4Q1LA 3DPEA 4DV8A 2J83A 5I43A 3WV3A 2OW0A 1GO7P 1I1IP 1MMBA 1HFCA 2MZIA 3LILA 1KUHA 4JIJA 1HTDA 4JP4A 3KEJA 4FVLA 2W0DA 2DW1A 1ZP5A 3ZVSA 2O3EA 1UTTA 966CA 2ERQA 3MA2A 1IAGA 1C8TA 3HDBA 2OXZA 3UVCA 3L0TA 3AYKA 3F15A 1G49A 2MLSA 1JJ9A 830CA 1BKCE 3G42A 3CKIA 4GR0A 4FXQA 2E3XA 4WKIA 1BZSA 1QIAA 3LIKA 3KEKA 3AYUA 2N8RA 3LJZA 1OMJA 3G5CA
chains in the Genus database with same CATH superfamily
1Q3AA 3ZXHA 1XFXA 1YOUA 2OY4A 1G05A 1FBLA 3HB2P 1Z3JA 4I03A 3RTSA 3B8ZA 2E2DA 3F1AA 4GR8A 2DW2A 3SHIA 1HOVA 2OW9A 1BIWA 2OW2A 2JNPA 4J4MA 1S4BP 2AYKA 1OS2A 4H30A 1KUKA 2YIGA 1CAQA 4WF6A 4AUOA 1JAOA 1SLNA 3EDZA 3LQBA 1BKCI 4G9LA 4L63A 5L79A 2K2GA 3DSLA 5LABA 1OM8A 3I7GA 2JT5A 2DW0A 4H84A 2HU6A 2QPJA 3P1VA 3P24A 4EFSA 1QIBA 3TVCA 3LK8A 1I76A 5D2BA 3TSKA 4I35A 1JKYA 4L19A 4XCTA 5I3MA 1AKLA 3RTTA 4DPEA 1CQRA 1MNCA 1JAQA 3Q2HA 1Y8JA 2K9CA 2OXUA 1O0TA 1H71P 2X3CA 3B2ZA 1I73A 1D5JA 1Y93A 3LJTA 1CGFA 2POJA 4GF1A 4JQGA 3WV2A 3USNA 1B3DA 2V4BA 2YB9A 1EB6A 3WV1A 1CK7A 1JH1A 1RM8A 3EDGA 1OM6A 1MMRA 4PKRA 5D7WA 1AYKA 1CGLA 1KUFA 3DPFA 2JSDA 4GR3A 2A8HA 4ON1A 1CGEA 2Z2DA 2D1OA 1C7KA 2OVZA 2OW1A 4L6TA 1UMTA 1XFWA 3KECA 1HFSA 3EDHA 3EWJA 1GE7A 1XURA 3F19A 3KMCA 2OY2A 1DMTA 5CZMA 4FU4A 2JIHA 4JPAA 5CUHA 1BSWA 4PKSA 2MLRA 3F18A 1BUVM 1BUDA 1ATLA 1XFYA 2YUFA 3E8RA 3B92A 1SU3A 3LIRA 5I12A 2MZEA 1GXDA 1L6JA 2FV5A 1SLMA 5JMYA 1R54A 1D7XA 1YQYA 1XAXA 5BPAA 2CLTA 2RJQA 1R1JA 5B5OA 1YP1A 1JIZA 2EROA 1EAKA 1AF0A 1PWQA 4A7BA 3TS4A 3HBVP 1GKCA 1K7GA 3K7NA 1KBCA 3VI1A 1R55A 2MZHA 3LJGA 4XM7A 4WKEA 1GE6A 2OI0A 3LUNA 2W14A 1ZVXA 1C3IA 4GWMA 1G12A 2XS4A 1SRPA 5I2ZA 1MMQA 4IUWA 2W12A 1HV5A 4AIGA 5CXAA 4H76A 2TCLA 3BA0A 4PKUA 2SRTA 4H82A 5BOYA 1D8MA 2X3BA 1GKDA 2KRJA 4ZR5A 3KWVC 3U1RA 2OVXA 1QJIA 1PWPA 1Y0VA 3LEAA 4PKWA 4WZVA 2OXWA 2CKIA 1UTZA 3LUMA 3HBUP 1OO9A 1OZ9A 2XS3A 5D1SA 3LMCA 2OZRA 5B5PA 2Y6CA 1JK3A 1KUIA 3ELMA 3TT4A 1WNIA 3DTEA 1BKCA 456CA 4IN9A 1YCMA 4DF9A 4DD8A 4GUYA 1RMZA 5BOTA 1ZXVA 3HYGA 4XM6A 3AIGA 2PJTA 3N2UA 4WK7A 4XBHA 4AYKA 1G4KA 3DL1A 1BQOA 3KHIA 1OM7A 1FM1A 4FXYP 3I7IA 1PWWA 1QUAA 1JAPA 1KAPP 4A3WA 4R3VA 1FLSA 1EUBA 4H1QA 4AXQA 1IAAA 2J0TA 1XFUA 2O36A 4HMAA 1HY7A 4PKTA 2W15A 3F16A 1A86A 3N2VA 1GO8P 4PKQA 4CTHA 3ZUKA 4IJOA 3LE9A 2ERPA 4QKZA 5I0LA 1ZXCA 3LKAA 5D3CA 2DDYA 1SMPA 3V96B 1IAEA 1TVIA 1BQQM 3LGPA 4H2EA 1MMPA 4HX3A 1PWUA 1XUCA 1J7NA 1A85A 4H3XA 3EDIA 2L0RA 2WO9A 4H49A 2DDFA 2W13A 1BM6A 1CXVA 4JA1A 2AIGP 1USNA 1SATA 1XFZA 4ILWD 5D1TA 1UEAA 3Q2GA 1XUDA 4GWNA 1DTHA 2Y6DA 4PKVA 1GE5A 1QJJA 3GBOA 3OHLA 1XM5A 2FV9A 2WOAA 3KMEA 1JANA 3O64A 4GQLA 1O0QA 5L7FA 1UMSA 1JIWP 1K7IA 1CIZA 2JT6A 2USNA 1ZTQA 1QICA 4G0DA 3LQ0A 3O2XA 3EHYA 5H8XA 2RJPA 2I47A 1R1IA 2X7MA 3L0VA 1B8YA 1ROSA 3DWBA 5I4OA 1K7QA 2X3AA 3EHXA 1G9KA 1R1HA 3F17A 1ND1A 1XFVA 1ASTA 4XM8A 2D1NA 1IADA 3K7LA 1IABA 3DNGA 3NX7A 3HY9A 3VTGA 1IACA 3OHOA 3HDAP 5D1UA 3DTKA 2WO8A 3HY7A 1OS9A 1PWVA 1ZS0A 3KRYA 1D8FA 1KUGA 4Q1LA 3DPEA 4DV8A 2J83A 5I43A 3WV3A 2OW0A 1GO7P 1I1IP 1MMBA 4L7AA 1HFCA 2MZIA 3LILA 1KUHA 4JIJA 1HTDA 4JP4A 3KEJA 4FVLA 2W0DA 2DW1A 1ZP5A 3ZVSA 2O3EA 1UTTA 966CA 2ERQA 3MA2A 1IAGA 3DTIA 1C8TA 3HDBA 2OXZA 3UVCA 3L0TA 3AYKA 3F15A 1G49A 2MLSA 1JJ9A 830CA 1BKCE 3G42A 3CKIA 4GR0A 4FXQA 2E3XA 4WKIA 1BZSA 1QIAA 3LIKA 3KEKA 3AYUA 2N8RA 3LJZA 1OMJA 3G5CA
chains in the Genus database with same CATH topology
1Q3AA 3ZXHA 1XFXA 1YOUA 2OY4A 1G05A 1FBLA 3HB2P 1Z3JA 4I03A 3RTSA 3B8ZA 2E2DA 3F1AA 4GR8A 2DW2A 3SHIA 1HOVA 2OW9A 1BIWA 2OW2A 2JNPA 4J4MA 1S4BP 2AYKA 1OS2A 4H30A 1KUKA 2YIGA 1CAQA 4WF6A 4AUOA 1JAOA 1SLNA 3EDZA 3LQBA 1BKCI 4G9LA 4L63A 5L79A 2K2GA 3DSLA 5LABA 1OM8A 3I7GA 2JT5A 2DW0A 4H84A 2HU6A 2QPJA 3P1VA 3P24A 4EFSA 1QIBA 3TVCA 3LK8A 1I76A 5D2BA 3TSKA 4I35A 1JKYA 4L19A 4XCTA 5I3MA 1AKLA 3RTTA 4DPEA 1CQRA 1MNCA 1JAQA 3Q2HA 1Y8JA 2K9CA 2OXUA 1O0TA 1H71P 2X3CA 3B2ZA 1I73A 1D5JA 1Y93A 3LJTA 1CGFA 2POJA 4GF1A 4JQGA 3WV2A 3USNA 1B3DA 2V4BA 2YB9A 1EB6A 3WV1A 1CK7A 1JH1A 1RM8A 3EDGA 1OM6A 1MMRA 4PKRA 5D7WA 1AYKA 1CGLA 1KUFA 3DPFA 2JSDA 4GR3A 2A8HA 4ON1A 1CGEA 2Z2DA 2D1OA 1C7KA 2OVZA 2OW1A 4L6TA 1UMTA 1XFWA 3KECA 1HFSA 3EDHA 3EWJA 1GE7A 1XURA 3F19A 3KMCA 2OY2A 1DMTA 5CZMA 4FU4A 2JIHA 4JPAA 5CUHA 1BSWA 4PKSA 2MLRA 3F18A 1BUVM 1BUDA 1ATLA 1XFYA 2YUFA 3E8RA 3B92A 1SU3A 3LIRA 5I12A 2MZEA 1GXDA 1L6JA 2FV5A 1SLMA 5JMYA 1R54A 1D7XA 1YQYA 5BPAA 2CLTA 2RJQA 1R1JA 5B5OA 1YP1A 1JIZA 2EROA 1EAKA 1AF0A 1PWQA 4A7BA 3TS4A 3HBVP 1GKCA 1K7GA 3K7NA 1KBCA 3VI1A 1R55A 2MZHA 3LJGA 4XM7A 4WKEA 1GE6A 2OI0A 3LUNA 2W14A 1ZVXA 1C3IA 4GWMA 1G12A 2XS4A 1SRPA 5I2ZA 1MMQA 4IUWA 2W12A 1HV5A 4AIGA 5CXAA 4H76A 2TCLA 3BA0A 4PKUA 2SRTA 4H82A 5BOYA 1D8MA 2X3BA 1GKDA 2KRJA 4ZR5A 3KWVC 3U1RA 2OVXA 1QJIA 1PWPA 1Y0VA 3LEAA 4PKWA 4WZVA 2OXWA 2CKIA 1UTZA 3LUMA 3HBUP 1OO9A 2XS3A 5D1SA 3LMCA 2OZRA 5B5PA 2Y6CA 1JK3A 1KUIA 3ELMA 3TT4A 1WNIA 3DTEA 1BKCA 456CA 4IN9A 1YCMA 4DF9A 4DD8A 4GUYA 1RMZA 5BOTA 1ZXVA 3HYGA 4XM6A 3AIGA 2PJTA 3N2UA 4WK7A 4XBHA 4AYKA 1G4KA 3DL1A 1BQOA 3KHIA 1OM7A 1FM1A 4FXYP 3I7IA 1PWWA 1QUAA 1JAPA 1KAPP 4A3WA 4R3VA 1FLSA 1EUBA 4H1QA 4AXQA 1IAAA 2J0TA 1XFUA 2O36A 4HMAA 1HY7A 4PKTA 2W15A 3F16A 1A86A 3N2VA 1GO8P 4PKQA 4CTHA 3ZUKA 4IJOA 3LE9A 2ERPA 4QKZA 5I0LA 1ZXCA 3LKAA 5D3CA 2DDYA 1SMPA 3V96B 1IAEA 1BQQM 3LGPA 4H2EA 1MMPA 4HX3A 1PWUA 1XUCA 1J7NA 1A85A 4H3XA 3EDIA 2L0RA 2WO9A 4H49A 2DDFA 2W13A 1BM6A 1CXVA 4JA1A 2AIGP 1USNA 1SATA 1XFZA 4ILWD 5D1TA 1UEAA 3Q2GA 1XUDA 4GWNA 1DTHA 2Y6DA 4PKVA 1GE5A 1QJJA 3GBOA 3OHLA 2FV9A 2WOAA 3KMEA 1JANA 3O64A 4GQLA 1O0QA 5L7FA 1UMSA 1JIWP 1K7IA 1CIZA 2JT6A 2USNA 1ZTQA 1QICA 4G0DA 3LQ0A 3O2XA 3EHYA 5H8XA 2RJPA 2I47A 1R1IA 2X7MA 3L0VA 1B8YA 1ROSA 3DWBA 5I4OA 1K7QA 2X3AA 3EHXA 1G9KA 1R1HA 3F17A 1ND1A 1XFVA 1ASTA 4XM8A 2D1NA 1IADA 3K7LA 1IABA 3DNGA 3NX7A 3HY9A 3VTGA 1IACA 3OHOA 3HDAP 5D1UA 3DTKA 2WO8A 3HY7A 1OS9A 1PWVA 1ZS0A 3KRYA 1D8FA 1KUGA 4Q1LA 3DPEA 4DV8A 2J83A 5I43A 3WV3A 2OW0A 1GO7P 1I1IP 1MMBA 4L7AA 1HFCA 2MZIA 3LILA 1KUHA 4JIJA 1HTDA 4JP4A 3KEJA 4FVLA 2W0DA 2DW1A 1ZP5A 3ZVSA 2O3EA 1UTTA 966CA 2ERQA 3MA2A 1IAGA 3DTIA 1C8TA 3HDBA 2OXZA 3UVCA 3L0TA 3AYKA 3F15A 1G49A 2MLSA 1JJ9A 830CA 1BKCE 3G42A 3CKIA 4GR0A 4FXQA 2E3XA 4WKIA 1BZSA 1QIAA 3LIKA 3KEKA 3AYUA 2N8RA 3LJZA 1OMJA 3G5CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Q3A A;  3ZXH A;  1XFX A;  1YOU A;  2OY4 A;  1G05 A;  1FBL A;  3HB2 P;  1Z3J A;  4I03 A;  3RTS A;  3B8Z A;  2E2D A;  3F1A A;  4GR8 A;  2DW2 A;  3SHI A;  1HOV A;  2OW9 A;  1BIW A;  2OW2 A;  2JNP A;  4J4M A;  1S4B P;  2AYK A;  1OS2 A;  4H30 A;  1KUK A;  2YIG A;  1CAQ A;  4WF6 A;  4AUO A;  1JAO A;  1SLN A;  3EDZ A;  3LQB A;  1BKC I;  4G9L A;  4L63 A;  5L79 A;  2K2G A;  3DSL A;  5LAB A;  1OM8 A;  3I7G A;  2JT5 A;  2DW0 A;  4H84 A;  2HU6 A;  2QPJ A;  3P1V A;  3P24 A;  4EFS A;  1QIB A;  3TVC A;  3LK8 A;  1I76 A;  5D2B A;  3TSK A;  4I35 A;  1JKY A;  4L19 A;  4XCT A;  5I3M A;  1AKL A;  3RTT A;  4DPE A;  1CQR A;  1MNC A;  1JAQ A;  3Q2H A;  1Y8J A;  2K9C A;  2OXU A;  1O0T A;  1H71 P;  2X3C A;  3B2Z A;  1I73 A;  1D5J A;  1Y93 A;  3LJT A;  1CGF A;  2POJ A;  4GF1 A;  4JQG A;  3WV2 A;  3USN A;  1B3D A;  2V4B A;  2YB9 A;  1EB6 A;  3WV1 A;  1CK7 A;  1JH1 A;  1RM8 A;  3EDG A;  1OM6 A;  1MMR A;  4PKR A;  5D7W A;  1AYK A;  1CGL A;  1KUF A;  3DPF A;  2JSD A;  4GR3 A;  2A8H A;  4ON1 A;  1CGE A;  2Z2D A;  2D1O A;  1C7K A;  2OVZ A;  2OW1 A;  4L6T A;  1UMT A;  1XFW A;  3KEC A;  1HFS A;  3EDH A;  3EWJ A;  1GE7 A;  1XUR A;  3F19 A;  3KMC A;  2OY2 A;  1DMT A;  5CZM A;  4FU4 A;  2JIH A;  4JPA A;  5CUH A;  1BSW A;  4PKS A;  2MLR A;  3F18 A;  1BUV M;  1BUD A;  1ATL A;  1XFY A;  3E8R A;  3B92 A;  1SU3 A;  3LIR A;  5I12 A;  2MZE A;  1GXD A;  1L6J A;  2FV5 A;  1SLM A;  5JMY A;  1R54 A;  1D7X A;  1YQY A;  5BPA A;  2CLT A;  2RJQ A;  1R1J A;  5B5O A;  1YP1 A;  1JIZ A;  2ERO A;  1EAK A;  1AF0 A;  1PWQ A;  4A7B A;  3TS4 A;  3HBV P;  1GKC A;  1K7G A;  3K7N A;  1KBC A;  3VI1 A;  1R55 A;  2MZH A;  3LJG A;  4XM7 A;  4WKE A;  1GE6 A;  2OI0 A;  3LUN A;  2W14 A;  1ZVX A;  1C3I A;  4GWM A;  1G12 A;  2XS4 A;  1SRP A;  5I2Z A;  1MMQ A;  4IUW A;  2W12 A;  1HV5 A;  4AIG A;  5CXA A;  4H76 A;  2TCL A;  3BA0 A;  4PKU A;  2SRT A;  4H82 A;  5BOY A;  1D8M A;  2X3B A;  1GKD A;  2KRJ A;  4ZR5 A;  3KWV C;  3U1R A;  2OVX A;  1QJI A;  1PWP A;  1Y0V A;  3LEA A;  4PKW A;  4WZV A;  2OXW A;  2CKI A;  1UTZ A;  3LUM A;  3HBU P;  1OO9 A;  2XS3 A;  5D1S A;  3LMC A;  2OZR A;  5B5P A;  2Y6C A;  1JK3 A;  1KUI A;  3ELM A;  3TT4 A;  1WNI A;  1BKC A;  456C A;  4IN9 A;  1YCM A;  4DF9 A;  4DD8 A;  4GUY A;  1RMZ A;  5BOT A;  1ZXV A;  3HYG A;  4XM6 A;  3AIG A;  2PJT A;  3N2U A;  4WK7 A;  4XBH A;  4AYK A;  1G4K A;  3DL1 A;  1BQO A;  3KHI A;  1OM7 A;  1FM1 A;  4FXY P;  3I7I A;  1PWW A;  1QUA A;  1JAP A;  1KAP P;  4A3W A;  4R3V A;  1FLS A;  1EUB A;  4H1Q A;  4AXQ A;  1IAA A;  2J0T A;  1XFU A;  2O36 A;  4HMA A;  1HY7 A;  4PKT A;  2W15 A;  3F16 A;  1A86 A;  3N2V A;  1GO8 P;  4PKQ A;  4CTH A;  3ZUK A;  4IJO A;  3LE9 A;  2ERP A;  4QKZ A;  5I0L A;  1ZXC A;  3LKA A;  5D3C A;  2DDY A;  1SMP A;  3V96 B;  1IAE A;  1BQQ M;  3LGP A;  4H2E A;  1MMP A;  4HX3 A;  1PWU A;  1XUC A;  1J7N A;  1A85 A;  4H3X A;  3EDI A;  2L0R A;  2WO9 A;  4H49 A;  2DDF A;  2W13 A;  1BM6 A;  1CXV A;  4JA1 A;  2AIG P;  1USN A;  1SAT A;  1XFZ A;  4ILW D;  5D1T A;  1UEA A;  3Q2G A;  1XUD A;  4GWN A;  1DTH A;  2Y6D A;  4PKV A;  1GE5 A;  1QJJ A;  3GBO A;  3OHL A;  2FV9 A;  2WOA A;  3KME A;  1JAN A;  3O64 A;  4GQL A;  1O0Q A;  5L7F A;  1UMS A;  1JIW P;  1K7I A;  1CIZ A;  2JT6 A;  2USN A;  1ZTQ A;  1QIC A;  4G0D A;  3LQ0 A;  3O2X A;  3EHY A;  5H8X A;  2RJP A;  2I47 A;  1R1I A;  2X7M A;  3L0V A;  1B8Y A;  1ROS A;  3DWB A;  5I4O A;  1K7Q A;  2X3A A;  3EHX A;  1G9K A;  1R1H A;  3F17 A;  1ND1 A;  1XFV A;  1AST A;  4XM8 A;  2D1N A;  1IAD A;  3K7L A;  1IAB A;  3DNG A;  3NX7 A;  3HY9 A;  3VTG A;  1IAC A;  3OHO A;  3HDA P;  5D1U A;  2WO8 A;  3HY7 A;  1OS9 A;  1PWV A;  1ZS0 A;  3KRY A;  1D8F A;  1KUG A;  4Q1L A;  3DPE A;  4DV8 A;  2J83 A;  5I43 A;  3WV3 A;  2OW0 A;  1GO7 P;  1I1I P;  1MMB A;  1HFC A;  2MZI A;  3LIL A;  1KUH A;  4JIJ A;  1HTD A;  4JP4 A;  3KEJ A;  4FVL A;  2W0D A;  2DW1 A;  1ZP5 A;  3ZVS A;  2O3E A;  1UTT A;  966C A;  2ERQ A;  3MA2 A;  1IAG A;  1C8T A;  3HDB A;  2OXZ A;  3UVC A;  3L0T A;  3AYK A;  3F15 A;  1G49 A;  2MLS A;  1JJ9 A;  830C A;  1BKC E;  3G42 A;  3CKI A;  4GR0 A;  4FXQ A;  2E3X A;  4WKI A;  1BZS A;  1QIA A;  3LIK A;  3KEK A;  3AYU A;  2N8R A;  3LJZ A;  1OMJ A;  3G5C A; 
#chains in the Genus database with same CATH topology
 1Q3A A;  3ZXH A;  1XFX A;  1YOU A;  2OY4 A;  1G05 A;  1FBL A;  3HB2 P;  1Z3J A;  4I03 A;  3RTS A;  3B8Z A;  2E2D A;  3F1A A;  4GR8 A;  2DW2 A;  3SHI A;  1HOV A;  2OW9 A;  1BIW A;  2OW2 A;  2JNP A;  4J4M A;  1S4B P;  2AYK A;  1OS2 A;  4H30 A;  1KUK A;  2YIG A;  1CAQ A;  4WF6 A;  4AUO A;  1JAO A;  1SLN A;  3EDZ A;  3LQB A;  1BKC I;  4G9L A;  4L63 A;  5L79 A;  2K2G A;  3DSL A;  5LAB A;  1OM8 A;  3I7G A;  2JT5 A;  2DW0 A;  4H84 A;  2HU6 A;  2QPJ A;  3P1V A;  3P24 A;  4EFS A;  1QIB A;  3TVC A;  3LK8 A;  1I76 A;  5D2B A;  3TSK A;  4I35 A;  1JKY A;  4L19 A;  4XCT A;  5I3M A;  1AKL A;  3RTT A;  4DPE A;  1CQR A;  1MNC A;  1JAQ A;  3Q2H A;  1Y8J A;  2K9C A;  2OXU A;  1O0T A;  1H71 P;  2X3C A;  3B2Z A;  1I73 A;  1D5J A;  1Y93 A;  3LJT A;  1CGF A;  2POJ A;  4GF1 A;  4JQG A;  3WV2 A;  3USN A;  1B3D A;  2V4B A;  2YB9 A;  1EB6 A;  3WV1 A;  1CK7 A;  1JH1 A;  1RM8 A;  3EDG A;  1OM6 A;  1MMR A;  4PKR A;  5D7W A;  1AYK A;  1CGL A;  1KUF A;  3DPF A;  2JSD A;  4GR3 A;  2A8H A;  4ON1 A;  1CGE A;  2Z2D A;  2D1O A;  1C7K A;  2OVZ A;  2OW1 A;  4L6T A;  1UMT A;  1XFW A;  3KEC A;  1HFS A;  3EDH A;  3EWJ A;  1GE7 A;  1XUR A;  3F19 A;  3KMC A;  2OY2 A;  1DMT A;  5CZM A;  4FU4 A;  2JIH A;  4JPA A;  5CUH A;  1BSW A;  4PKS A;  2MLR A;  3F18 A;  1BUV M;  1BUD A;  1ATL A;  1XFY A;  2YUF A;  3E8R A;  3B92 A;  1SU3 A;  3LIR A;  5I12 A;  2MZE A;  1GXD A;  1L6J A;  2FV5 A;  1SLM A;  5JMY A;  1R54 A;  1D7X A;  1YQY A;  1XAX A;  5BPA A;  2CLT A;  2RJQ A;  1R1J A;  5B5O A;  1YP1 A;  1JIZ A;  2ERO A;  1EAK A;  1AF0 A;  1PWQ A;  4A7B A;  3TS4 A;  3HBV P;  1GKC A;  1K7G A;  3K7N A;  1KBC A;  3VI1 A;  1R55 A;  2MZH A;  3LJG A;  4XM7 A;  4WKE A;  1GE6 A;  2OI0 A;  3LUN A;  2W14 A;  1ZVX A;  1C3I A;  4GWM A;  1G12 A;  2XS4 A;  1SRP A;  5I2Z A;  1MMQ A;  4IUW A;  2W12 A;  1HV5 A;  4AIG A;  5CXA A;  4H76 A;  2TCL A;  3BA0 A;  4PKU A;  2SRT A;  4H82 A;  5BOY A;  1D8M A;  2X3B A;  1GKD A;  2KRJ A;  4ZR5 A;  3KWV C;  3U1R A;  2OVX A;  1QJI A;  1PWP A;  1Y0V A;  3LEA A;  4PKW A;  4WZV A;  2OXW A;  2CKI A;  1UTZ A;  3LUM A;  3HBU P;  1OO9 A;  1OZ9 A;  2XS3 A;  5D1S A;  3LMC A;  2OZR A;  5B5P A;  2Y6C A;  1JK3 A;  1KUI A;  3ELM A;  3TT4 A;  1WNI A;  3DTE A;  1BKC A;  456C A;  4IN9 A;  1YCM A;  4DF9 A;  4DD8 A;  4GUY A;  1RMZ A;  5BOT A;  1ZXV A;  3HYG A;  4XM6 A;  3AIG A;  2PJT A;  3N2U A;  4WK7 A;  4XBH A;  4AYK A;  1G4K A;  3DL1 A;  1BQO A;  3KHI A;  1OM7 A;  1FM1 A;  4FXY P;  3I7I A;  1PWW A;  1QUA A;  1JAP A;  1KAP P;  4A3W A;  4R3V A;  1FLS A;  1EUB A;  4H1Q A;  4AXQ A;  1IAA A;  2J0T A;  1XFU A;  2O36 A;  4HMA A;  1HY7 A;  4PKT A;  2W15 A;  3F16 A;  1A86 A;  3N2V A;  1GO8 P;  4PKQ A;  4CTH A;  3ZUK A;  4IJO A;  3LE9 A;  2ERP A;  4QKZ A;  5I0L A;  1ZXC A;  3LKA A;  5D3C A;  2DDY A;  1SMP A;  3V96 B;  1IAE A;  1TVI A;  1BQQ M;  3LGP A;  4H2E A;  1MMP A;  4HX3 A;  1PWU A;  1XUC A;  1J7N A;  1A85 A;  4H3X A;  3EDI A;  2L0R A;  2WO9 A;  4H49 A;  2DDF A;  2W13 A;  1BM6 A;  1CXV A;  4JA1 A;  2AIG P;  1USN A;  1SAT A;  1XFZ A;  4ILW D;  5D1T A;  1UEA A;  3Q2G A;  1XUD A;  4GWN A;  1DTH A;  2Y6D A;  4PKV A;  1GE5 A;  1QJJ A;  3GBO A;  3OHL A;  1XM5 A;  2FV9 A;  2WOA A;  3KME A;  1JAN A;  3O64 A;  4GQL A;  1O0Q A;  5L7F A;  1UMS A;  1JIW P;  1K7I A;  1CIZ A;  2JT6 A;  2USN A;  1ZTQ A;  1QIC A;  4G0D A;  3LQ0 A;  3O2X A;  3EHY A;  5H8X A;  2RJP A;  2I47 A;  1R1I A;  2X7M A;  3L0V A;  1B8Y A;  1ROS A;  3DWB A;  5I4O A;  1K7Q A;  2X3A A;  3EHX A;  1G9K A;  1R1H A;  3F17 A;  1ND1 A;  1XFV A;  1AST A;  4XM8 A;  2D1N A;  1IAD A;  3K7L A;  1IAB A;  3DNG A;  3NX7 A;  3HY9 A;  3VTG A;  1IAC A;  3OHO A;  3HDA P;  5D1U A;  3DTK A;  2WO8 A;  3HY7 A;  1OS9 A;  1PWV A;  1ZS0 A;  3KRY A;  1D8F A;  1KUG A;  4Q1L A;  3DPE A;  4DV8 A;  2J83 A;  5I43 A;  3WV3 A;  2OW0 A;  1GO7 P;  1I1I P;  1MMB A;  4L7A A;  1HFC A;  2MZI A;  3LIL A;  1KUH A;  4JIJ A;  1HTD A;  4JP4 A;  3KEJ A;  4FVL A;  2W0D A;  2DW1 A;  1ZP5 A;  3ZVS A;  2O3E A;  1UTT A;  966C A;  2ERQ A;  3MA2 A;  1IAG A;  3DTI A;  1C8T A;  3HDB A;  2OXZ A;  3UVC A;  3L0T A;  3AYK A;  3F15 A;  1G49 A;  2MLS A;  1JJ9 A;  830C A;  1BKC E;  3G42 A;  3CKI A;  4GR0 A;  4FXQ A;  2E3X A;  4WKI A;  1BZS A;  1QIA A;  3LIK A;  3KEK A;  3AYU A;  2N8R A;  3LJZ A;  1OMJ A;  3G5C A; 
#chains in the Genus database with same CATH homology
 1Q3A A;  3ZXH A;  1XFX A;  1YOU A;  2OY4 A;  1G05 A;  1FBL A;  3HB2 P;  1Z3J A;  4I03 A;  3RTS A;  3B8Z A;  2E2D A;  3F1A A;  4GR8 A;  2DW2 A;  3SHI A;  1HOV A;  2OW9 A;  1BIW A;  2OW2 A;  2JNP A;  4J4M A;  1S4B P;  2AYK A;  1OS2 A;  4H30 A;  1KUK A;  2YIG A;  1CAQ A;  4WF6 A;  4AUO A;  1JAO A;  1SLN A;  3EDZ A;  3LQB A;  1BKC I;  4G9L A;  4L63 A;  5L79 A;  2K2G A;  3DSL A;  5LAB A;  1OM8 A;  3I7G A;  2JT5 A;  2DW0 A;  4H84 A;  2HU6 A;  2QPJ A;  3P1V A;  3P24 A;  4EFS A;  1QIB A;  3TVC A;  3LK8 A;  1I76 A;  5D2B A;  3TSK A;  4I35 A;  1JKY A;  4L19 A;  4XCT A;  5I3M A;  1AKL A;  3RTT A;  4DPE A;  1CQR A;  1MNC A;  1JAQ A;  3Q2H A;  1Y8J A;  2K9C A;  2OXU A;  1O0T A;  1H71 P;  2X3C A;  3B2Z A;  1I73 A;  1D5J A;  1Y93 A;  3LJT A;  1CGF A;  2POJ A;  4GF1 A;  4JQG A;  3WV2 A;  3USN A;  1B3D A;  2V4B A;  2YB9 A;  1EB6 A;  3WV1 A;  1CK7 A;  1JH1 A;  1RM8 A;  3EDG A;  1OM6 A;  1MMR A;  4PKR A;  5D7W A;  1AYK A;  1CGL A;  1KUF A;  3DPF A;  2JSD A;  4GR3 A;  2A8H A;  4ON1 A;  1CGE A;  2Z2D A;  2D1O A;  1C7K A;  2OVZ A;  2OW1 A;  4L6T A;  1UMT A;  1XFW A;  3KEC A;  1HFS A;  3EDH A;  3EWJ A;  1GE7 A;  1XUR A;  3F19 A;  3KMC A;  2OY2 A;  1DMT A;  5CZM A;  4FU4 A;  2JIH A;  4JPA A;  5CUH A;  1BSW A;  4PKS A;  2MLR A;  3F18 A;  1BUV M;  1BUD A;  1ATL A;  1XFY A;  2YUF A;  3E8R A;  3B92 A;  1SU3 A;  3LIR A;  5I12 A;  2MZE A;  1GXD A;  1L6J A;  2FV5 A;  1SLM A;  5JMY A;  1R54 A;  1D7X A;  1YQY A;  5BPA A;  2CLT A;  2RJQ A;  1R1J A;  5B5O A;  1YP1 A;  1JIZ A;  2ERO A;  1EAK A;  1AF0 A;  1PWQ A;  4A7B A;  3TS4 A;  3HBV P;  1GKC A;  1K7G A;  3K7N A;  1KBC A;  3VI1 A;  1R55 A;  2MZH A;  3LJG A;  4XM7 A;  4WKE A;  1GE6 A;  2OI0 A;  3LUN A;  2W14 A;  1ZVX A;  1C3I A;  4GWM A;  1G12 A;  2XS4 A;  1SRP A;  5I2Z A;  1MMQ A;  4IUW A;  2W12 A;  1HV5 A;  4AIG A;  5CXA A;  4H76 A;  2TCL A;  3BA0 A;  4PKU A;  2SRT A;  4H82 A;  5BOY A;  1D8M A;  2X3B A;  1GKD A;  2KRJ A;  4ZR5 A;  3KWV C;  3U1R A;  2OVX A;  1QJI A;  1PWP A;  1Y0V A;  3LEA A;  4PKW A;  4WZV A;  2OXW A;  2CKI A;  1UTZ A;  3LUM A;  3HBU P;  1OO9 A;  2XS3 A;  5D1S A;  3LMC A;  2OZR A;  5B5P A;  2Y6C A;  1JK3 A;  1KUI A;  3ELM A;  3TT4 A;  1WNI A;  3DTE A;  1BKC A;  456C A;  4IN9 A;  1YCM A;  4DF9 A;  4DD8 A;  4GUY A;  1RMZ A;  5BOT A;  1ZXV A;  3HYG A;  4XM6 A;  3AIG A;  2PJT A;  3N2U A;  4WK7 A;  4XBH A;  4AYK A;  1G4K A;  3DL1 A;  1BQO A;  3KHI A;  1OM7 A;  1FM1 A;  4FXY P;  3I7I A;  1PWW A;  1QUA A;  1JAP A;  1KAP P;  4A3W A;  4R3V A;  1FLS A;  1EUB A;  4H1Q A;  4AXQ A;  1IAA A;  2J0T A;  1XFU A;  2O36 A;  4HMA A;  1HY7 A;  4PKT A;  2W15 A;  3F16 A;  1A86 A;  3N2V A;  1GO8 P;  4PKQ A;  4CTH A;  3ZUK A;  4IJO A;  3LE9 A;  2ERP A;  4QKZ A;  5I0L A;  1ZXC A;  3LKA A;  5D3C A;  2DDY A;  1SMP A;  3V96 B;  1IAE A;  1BQQ M;  3LGP A;  4H2E A;  1MMP A;  4HX3 A;  1PWU A;  1XUC A;  1J7N A;  1A85 A;  4H3X A;  3EDI A;  2L0R A;  2WO9 A;  4H49 A;  2DDF A;  2W13 A;  1BM6 A;  1CXV A;  4JA1 A;  2AIG P;  1USN A;  1SAT A;  1XFZ A;  4ILW D;  5D1T A;  1UEA A;  3Q2G A;  1XUD A;  4GWN A;  1DTH A;  2Y6D A;  4PKV A;  1GE5 A;  1QJJ A;  3GBO A;  3OHL A;  2FV9 A;  2WOA A;  3KME A;  1JAN A;  3O64 A;  4GQL A;  1O0Q A;  5L7F A;  1UMS A;  1JIW P;  1K7I A;  1CIZ A;  2JT6 A;  2USN A;  1ZTQ A;  1QIC A;  4G0D A;  3LQ0 A;  3O2X A;  3EHY A;  5H8X A;  2RJP A;  2I47 A;  1R1I A;  2X7M A;  3L0V A;  1B8Y A;  1ROS A;  3DWB A;  5I4O A;  1K7Q A;  2X3A A;  3EHX A;  1G9K A;  1R1H A;  3F17 A;  1ND1 A;  1XFV A;  1AST A;  4XM8 A;  2D1N A;  1IAD A;  3K7L A;  1IAB A;  3DNG A;  3NX7 A;  3HY9 A;  3VTG A;  1IAC A;  3OHO A;  3HDA P;  5D1U A;  3DTK A;  2WO8 A;  3HY7 A;  1OS9 A;  1PWV A;  1ZS0 A;  3KRY A;  1D8F A;  1KUG A;  4Q1L A;  3DPE A;  4DV8 A;  2J83 A;  5I43 A;  3WV3 A;  2OW0 A;  1GO7 P;  1I1I P;  1MMB A;  4L7A A;  1HFC A;  2MZI A;  3LIL A;  1KUH A;  4JIJ A;  1HTD A;  4JP4 A;  3KEJ A;  4FVL A;  2W0D A;  2DW1 A;  1ZP5 A;  3ZVS A;  2O3E A;  1UTT A;  966C A;  2ERQ A;  3MA2 A;  1IAG A;  3DTI A;  1C8T A;  3HDB A;  2OXZ A;  3UVC A;  3L0T A;  3AYK A;  3F15 A;  1G49 A;  2MLS A;  1JJ9 A;  830C A;  1BKC E;  3G42 A;  3CKI A;  4GR0 A;  4FXQ A;  2E3X A;  4WKI A;  1BZS A;  1QIA A;  3LIK A;  3KEK A;  3AYU A;  2N8R A;  3LJZ A;  1OMJ A;  3G5C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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